Medical Image Super-Resolution

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4 papers in the last four weeks, up 33% on the four weeks before. 0.0% of all new papers.

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Latest papers 31

Sep 30, 2026cs.CV

MRI Super-Resolution with RCDM/WaveMix and Task-Aware Segmentation

Super-resolution and quality enhancement of 1.5,T brain MRI are normally validated with image-fidelity metrics, although their purpose is to improve downstream analysis. We study whether enhancement improves tissue segmentation, and for which segmenters. We propose an unpaired, physics-guided training pipeline for a lightweight (

\le

2.5,M parameter) recurrent convolutional enhancer: a six-module stochastic 1.5,T degradation operator, a residual adversarial network that adds scanner-specific texture without moving anatomy, and a cycle-consistent objective with an anti-identity penalty that rules out the copy solution. We then train U-Net, Swin-UNet and wavelet token-mixing segmenters \citep{jeevan2023wavemix} from scratch on either raw or enhanced 1.5,T images of the same subjects, using identical labels and subject-level splits, for three enhancer variants and two datasets. On ABIDE (41 held-out subjects, FreeSurfer labels) enhancement significantly improves the wavelet segmenter (mean Dice

+0.014

, Wilcoxon

p=3.5\times10^{-5}

; CSF

+0.018

, grey matter

+0.013

), significantly degrades the U-Net (

-0.008

,

p=5.1\times10^{-4}

) and leaves Swin-UNet unchanged. On IXI, whose labels come from FSL-FAST, enhancement lowers Dice for all nine pairings, almost entirely through CSF; we trace this to spatially implausible CSF voxels in the labels that penalise smoother predictions. Enhancement of low-field MRI should therefore be validated per downstream model and against reliable labels.

Kavitha Viswanathan, Harsh Choudhary, Amit Sethi

Department of Electrical Engineering, Indian Institute of Technology Bombay, Mumbai 400 076, India

Medical Image Analysis Medical Image Super-Resolution Medical Image Segmentation Unpaired Image-to-Image Translation Brain MRI

Sep 29, 2026cs.CV

You Cannot Recover What Was Never Measured: Quantifying the Information Ceiling of Ultra-Low-Field MRI Super-Resolution

Generative super-resolution models can turn portable 64 mT MRI into images that look like 3T scans, and the field evaluates them with PSNR, SSIM, and pixelwise uncertainty, most often on pairs built by synthetically degrading high-field images. Prior work acknowledges that these models hallucinate and that the problem is ill posed, but to our knowledge no study measures how much information about the individual subject the real low-field scan actually contains. We measure it. Using paired 64 mT and 3T scans of the same subjects from three public datasets, and a measurement protocol validated on tests whose correct answer is known in advance, we find that, judged over the whole brain, real 64 mT scans carry structure specific to the individual only down to approximately 3 to 4 mm half-pitch in plane, and coarser still through plane. Standard synthetic degradations preserve subject information roughly 1 mm beyond this ceiling, so models trained and benchmarked on synthetic pairs are evaluated on information that real scanners never record. We then test trained diffusion models and a publicly released external model on real paired acquisitions; 24 trained runs of five architectures (GAN, diffusion, and transformer families) give the coverage of the audit. On every subject where faithfulness can be measured, fine output detail is no more correlated with the subject's own 3T scan than with a stranger's, while sample-variance uncertainty does not distinguish fabricated structure from reconstruction difficulty. Because PSNR and SSIM score resemblance to a reference rather than whether detail belongs to the subject, a benchmark scored by them cannot tell recovery from fabrication. Code for the measurement protocol will be released so that recoverability claims can be tested for newer models.

Prathamesh Pradeep Khole, Shreya Handa, Utkarsh Gupta +1

University of California, Santa Cruz · Johns Hopkins University

Image Reconstruction Medical Image Super-Resolution Magnetic Resonance Imaging

Sep 28, 2026cs.CV

From Pixel Generation to Topological Inference: Structural Dual Super-Resolution for Trustworthy Cross-Physical-Domain Trabecular Morphology Learning

Clinical CT and UHRCT cannot resolve individual trabeculae, whereas synchrotron radiation microCT (SRuCT) provides high-resolution references but is not applicable for in vivo imaging. The two domains differ by a 32x resolution gap, are only coarsely paired, and exhibit severe physical differences including partial volume effects, noise, and artifacts. Existing super-resolution networks and pretrained-prior methods (GLEAN/StyleGAN2, Stable SR/LDM) underperform because they target pixel generation---diverse details and SSIM/PSNR---and do not model these physical differences. Pixel generation for a 32x resolution gap is intrinsically ill-posed. We propose a paradigm shift from pixel generation to topological inference: deterministically predicting invariant microstructures from macro-scale low-resolution inputs, evaluated by morphological parameters. The core of our 2D morphology learning lies in training on 2D slices while evaluating on 3D morphological parameters, ensuring that the learned representations capture true three-dimensional trabecular topology rather than 2D pixel statistics. We realize this paradigm via structural dual super-resolution, coupling forward physical degradation (micro-to-macro) with inverse structural inference (macro-to-micro) through structural duality constraints. The method is an end-to-end, few-shot, compact structural dual network (SDN), comprising a bidirectional modeling network, a multi-scale structural consistency discriminator, and four structural duality constraints. On the test set, SDN achieves morphological parameters largely consistent with SRuCT across six metrics, with SSIM reaching 0.8. Trained on 3.2 um SSRF data, the model generalizes well to 3.25 um isotropic BSRF data from an independent source, validating cross-source generalization and confirming trustworthy structural inference rather than pixel generation.

Fan Zhang, Yi Zhang, Ling Wang

Institute of High Energy Physics, Chinese Academy of Sciences Beijing 100049, China · Department of Radiology Beijing Jishuitan Hospital Beijing, China

3D Medical Imaging Medical Image Super-Resolution Computed Tomography Image Super-Resolution

Sep 11, 2026cs.CV

CEM-TUDASR: Computationally efficient multi-modality transformer based unsupervised domain adaptive super-resolution approach

Wireless Capsule Endoscopy (WCE) enables non-invasive visualization of the gastrointestinal tract, but its miniaturized optics, sensor limitations, and wireless transmission constraints result in low-resolution images with reduced visibility of diagnostically important structures. This paper proposes CEM-TUDASR, a computationally efficient unsupervised Transformer-based super-resolution framework for WCE image enhancement without paired low-resolution (LR) and high-resolution (HR) training data. A domain-adaptive degradation network synthesizes realistic WCE-like LR images from HR conventional endoscopy images, reducing the domain gap and enabling effective unpaired learning. The SR generator integrates Deep Attention Blocks (DABs) and a Fusion Attention Block (FAB) to capture long-range contextual dependencies and fine local structures while preserving perceptual and structural fidelity. The model is trained on a curated dataset derived from Kvasir Capsule and evaluated on KID and GIANA for cross-dataset generalization. No-reference quality metrics, including BRISQUE, PIQE, NIQE, and the domain-specific EndoQM, show that CEM-TUDASR consistently outperforms existing unsupervised SR methods. Qualitative results further demonstrate improved restoration of mucosal textures, vascular patterns, and clinically relevant anatomical details. Cross-domain experiments on retinal images additionally demonstrate the adaptability of the framework. With only 2.67 million parameters and 169.94 GFLOPs, CEM-TUDASR achieves high-quality reconstruction while maintaining computational efficiency, making it suitable for resource-constrained clinical and embedded endoscopic applications.

Anjali Sarvaiya, Jay Kadel, Kishor Upla +1

Sardar Vallabhbhai National Institute of Technology (SVNIT), Surat, India.

Unsupervised Domain Adaptation Medical Image Super-Resolution Image Super-Resolution

Sep 1, 2026eess.IV

Prior-Guided Implicit Neural Representations for Single-Subject Diffusion MRI Super-Resolution

Resolving complex fiber geometries in brain white matter requires high-resolution diffusion MRI at the cost of long acquisition times. This leads many clinical protocols to opt for low-resolution scans, making downstream microstructure estimation and tractography challenging. Implicit neural representations (INRs) can model the diffusion signal continuously, enabling native single-subject super-resolution by querying the network at arbitrary spatial coordinates, yet existing methods often suffer from long training times and lack a mechanism to incorporate anatomical priors to regularize super-resolution by constraining the space of plausible reconstructions. To address these limitations, we propose a novel transfer-learning framework that pre-trains an INR on a high-resolution template and then adapts it to subject-specific scans via registration and fine-tuning. For

4\times

through-plane super-resolution from 5 mm to 1.25 mm on Human Connectome Project (HCP) data, our method reduces NRMSE by 36-49% and increases FSIM by 24-43% over a recent baseline with

6\times

faster training, outperforming competing INR-based methods across both image quality and domain-specific metrics. Code is available on the project page at https://abdulkaderghandoura.github.io/research/msc-thesis/ .

Abdulkader Ghandoura, Marsil Zakour, William Consagra +1

Psychiatry Neuroimaging Laboratory Brigham and Women’s Hospital Harvard Medical School Boston, MA, USA · School of Computation, Information and Technology Technical University of Munich Munich, Germany · Department of Statistics University of South Carolina Columbia, SC, USA

Implicit Neural Representations Medical Image Super-Resolution Transfer Learning Diffusion MRI

Aug 27, 2026cs.CV

Tissue-Mixture Entropy-Weighted Reconstruction for Partial-Volume-Aware Brain MRI Super-Resolution

Background and Objectives: Full-image objectives in brain magnetic resonance imaging (MRI) super-resolution (SR) can underweight tissue-transition regions affected by the partial-volume effect (PVE), as these regions occupy a small fraction of the image. Binary boundaries further provide only a discrete approximation of continuous tissue mixtures within a voxel. Methods: We propose Anatomy-Guided Gaussian-Parameter Warping with PVE-Balanced Reconstruction (AGW-PBR), combining a low-resolution (LR)-only reconstruction backbone with a PVE-aware training objective. The backbone uses LR-derived anatomical guidance, soft latent assignment, and bounded residual warping. Quality-controlled tissue fractions are converted into tissue-mixture entropy to spatially weight reconstruction within validated PVE support. PVE sidecars are used only during training, while inference requires only the LR image. Downstream utility is further evaluated through zero-shot transfer to whole-tumor segmentation on BraTS2023. Results: AGW-PBR improves reconstruction across 2x and 4x SR on IXI and achieves the lowest normalized gradient-vector reconstruction error at both CSF--GM and GM--WM interfaces at 4x. Ablation studies verify the contributions of PVE-aware weighting and soft latent assignment. The PVE-free AGW backbone also maintains strong performance on fastMRI. On BraTS2023, AGW-PBR achieves competitive whole-tumor Dice and the lowest HD95 under direct zero-shot transfer. Conclusions:AGW-PBR improves brain MRI SR while preserving tissue-transition information relevant to downstream analysis. The results support tissue-mixture entropy as an effective supervision signal for partial-volume-aware MRI reconstruction.

Xiao Tong, Wenyun Yang, Ziheng Zhang +3

aState Key Laboratory of Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing, 100871, P. R. China · bWeihai Institute of Oceanology, Peking University, Weihai, 264209, P. R. China · cBeijing MagnVue Medix Co., Ltd., Beijing, 100085, P. R. China

Medical Image Super-Resolution Brain MRI Adaptive Loss Weighting

Aug 10, 2026cs.CV

MPISuperRes-PnP: A Super-Resolution Zero-Shot Plug-and-Play Reconstruction Algorithm for Magnetic Particle Imaging

Magnetic Particle Imaging (MPI) is an emerging medical imaging modality. MPI is based on the non-linear response of magnetic nanoparticles to an applied magnetic field and avoids ionizing radiation. The measured signal is the voltage induced in receive coils by the particles' response. Reconstructing the particle concentration from the signal constitutes the imaging task. Even using state-of-the-art measurement-based reconstruction, the associated spatial grid is very coarse, hence super-resolution (SR) techniques are important. In this work, we propose an approach for SR in MPI inspired by energy minimization. Different methods have been proposed for SR in MPI, ranging from upscaling of the associated system matrix to interpolation of the reconstruction. Here we incorporate SR into the reconstruction task via an energy minimization formulation. Following the plug-and-play approach to energy minimization we derive a splitting scheme and a SR method for MPI where the arising Gaussian denoising task is treated with a pre-trained learned Gaussian denoiser in a zero-shot fashion. This way, we incorporate benefits of deep learning without training and avoid the need of training data. Further, we provide a quantitative and qualitative evaluation of the proposed method. Hyper-parameter are selected via an extended parameter search. The found parameters are applied for reconstruction on real data. We show the applicability of our method on synthetic and on real data (MPIData: EquilibriumModelWithAnisotropy and 2D-OpenMPI Data). The proposed method employs a deep-learning denoiser without training -- thus it does not require presently scarcely available MPI training data. The denoiser behaves conservatively, i.e., no hallucination artifacts were observed. The SR approach is generic such that it can be applied in future MPI contexts involving different regularizers or different imaging tasks.

Vladyslav Gapyak, Thomas März, Andreas Weinmann

Institute for the Protection of Terrestrial Infrastructures, German Aerospace Center (DLR), Sankt Augustin, Germany · Hochschule Darmstadt, Schöfferstr. 3, 64295, Darmastdt, Germany · Data Science Institute, European University of Technology, European Union +1

Medical Imaging Image Reconstruction Medical Image Super-Resolution Image Super-Resolution

Aug 9, 2026cs.CV

MRI super-resolution in ten sampling steps using a diffusion bridge model

Objective. MRI provides excellent soft-tissue contrast, but long acquisition times can cause patient discomfort and lead to motion artifacts, forcing a trade-off between spatial resolution and scan time. Diffusion-based super-resolution (SR) reconstructs high-resolution (HR) images from low-resolution (LR) inputs, but typically needs many sampling steps and initializes from a Gaussian prior ill-suited to image restoration. We developed an efficient diffusion framework that reconstructs HR MRI directly from LR data. Approach. We propose super-resolution diffusion bridge model (SR-DBM), a super-resolution diffusion bridge model that casts SR as a stochastic transport between the LR and HR image distributions. Through a Doob's h-transform of a mean-reverting stochastic differential equation, SR-DBM pins the process to the paired HR and LR images at its endpoints, initializing reconstruction from the measured anatomy rather than from Gaussian noise. The HR image is recovered by a deterministic reverse trajectory in which a network predicts the clean image at each of only ten sampling steps. We evaluated SR-DBM on ultra-high-field 7T brain T1 MP2RAGE maps and pelvic T2-weighted prostate images against nine comparison methods using PSNR, SSIM, GMSD, and LPIPS. Main results. SR-DBM attained the highest PSNR and SSIM and the lowest GMSD on both datasets (brain: 27.66+-1.52 dB, 0.96+-0.02, 7.96+-1.86$; prostate: 27.87+-2.29 dB, 0.80+-0.05, 8.38+- 1.44), with statistically significant gains over every comparison method (two-sided Wilcoxon signed-rank test with Holm correction, p<0.05). The strongest baseline, SR-EMamba, ranked second. Qualitatively, SR-DBM produced the smallest residual errors and best preserved fine structures and lesions.

Mojtaba Safari, Hang Yu, Zach Eidex +10

Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, United States · Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States · Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, United States +3

Medical Image Super-Resolution Diffusion-Based Inverse Problems Diffusion MRI Diffusion Model Acceleration Brain MRI Diffusion Models

Aug 9, 2026cs.CV

Anatomically Consistent Cross-Contrast Super-Resolution of Anisotropic Brain T2w MRI

T2-weighted (T2w) brain MRI provides fluid-sensitive soft-tissue contrast that is important for neuro-oncology and radiotherapy planning. However, T2w scans are acquired with anisotropic voxels and appear blurred or stair-stepped on coronal and sagittal views, which obscures small structures and weakens any downstream 3D analysis. We propose VIPP-SR (View-Independent Patched Projection Super-Resolution), a cross-contrast guided super-resolution framework that restores the inter-plane resolution of an existing anisotropic T2w volume without an isotropic ground-truth T2w. VIPP-SR first trains a view-independent patched generator (VIP-GAN) to learn local T1c-to-T2w anatomical correspondence from high-resolution axial slices. The trained generator is then applied to axial, coronal, and sagittal views of the T1c volume to generate three orthogonal T2w estimates. Shape-preserving patching and deepest-skip removal reduce view-specific shortcuts, thereby constraining the generator to learn patch-local representations and enabling the zero-shot inter-plane transfer. Central to VIPP-SR, a projection-based optimization then enforces anatomical consistency across the three view-specific volumes, fusing them by balancing inter-plane self-consistency against per-view data fidelity. The generator is trained on BraTS-MET and evaluated on both the held-out BraTS-MET testing set and the BraTS-GLI cohort without retraining, assessing the cross-cohort generalizability. The results validate that VIPP-SR improves downstream segmentation over the real anisotropic T2w baseline, raising mean-label Dice from 0.330 to 0.465 on BraTS-MET and, zero-shot, from 0.473 to 0.563 on BraTS-GLI and ablation studies identify inter-plane self-consistency as the main source of the gain.

Mengqi Shen, Haicheng Wang, Meghna Trivedi +4

Data Science Institute, Columbia University, New York, NY, USA · Department of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH, USA · Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA +2

Medical Image Super-Resolution Brain MRI Generative Adversarial Networks

Aug 6, 2026cs.CV

Does FLAIR super-resolution erase or hallucinate small white-matter lesions?

White matter hyperintensities (WMH), bright regions on Fluid-attenuated Inversion Recovery (FLAIR) scans are associated with cerebrovascular pathology and neurodegeneration. FLAIR is usually acquired with thick slices in clinical settings, giving it poor through-plane resolution. Super-resolution (SR) is a widely used method for recovering an isotropic volume from an anisotropic scan. Yet whether applying it prior to WMH segmentation preserves lesion content remains unknown: a model may erase small real lesions or hallucinate absent ones. We used 1-mm isotropic high-resolution (HR) FLAIR scans from 29 individuals in the ADNI cohort, each manually segmented for WMH by an expert. Then, we degraded each to simulated 3 and 5 mm through-plane acquisitions. Multi-contrast implicit neural representation (INR), a single-contrast self-supervised model (ECLARE), and cubic interpolation were used to upsample them onto the HR grid. WMH segmentation from a simulated thick slice and the original HR FLAIR set the floor and ceiling, respectively, for the per-lesion analysis. Of four WMH segmentation methods (WMH-SynthSeg, segcsvd, MARS-WMH, TrUE-Net), we ran the analysis under the most sensitive one to small lesions on HR (MARS-WMH) with the evaluation metrics of detection sensitivity, erasure rate (HR-detected lesions lost after reconstruction), and hallucination rate (predicted components absent from both the manual and HR segmentation). The dominant effect of SR was erasure of small real lesions, not hallucination, and it increased with slice thickness, though every reconstruction still improved lesion detection over the raw thick slice. ECLARE recovered small lesion signal best at both thicknesses, while the INR was no better than cubic interpolation.

Zahra Khodakarami, Yue Li, Pulkit Khandelwal +5

University of Pennsylvania, Philadelphia, PA, USA

Medical Image Super-Resolution Magnetic Resonance Imaging Medical Image Segmentation

Aug 4, 2026cs.CV

Morphology-Aware Implicit Super-Resolution Network for Pathological Images

Accurate diagnosis in Digital Pathology (DP) relies on high-resolution whole-slide images, yet clinical deployment is often limited by hardware costs. Super-Resolution (SR) offers a promising alternative by computationally enhancing low-resolution acquisitions. However, existing SR methods frequently struggle to preserve fine-grained cellular morphology, leading to texture oversmoothing and blurred structural boundaries under complex tissue variability. To address this issue, we propose Morph-ISR, a morphology-aware implicit super-resolution framework for DP that restores diagnostically relevant details with sub-pixel precision. Morph-ISR reformulates SR as a continuous coordinate-based reconstruction problem and integrates an Implicit Position-aware Kernel Generator (IPKG) to adaptively model spatially varying tissue morphology. To further enhance structural fidelity, a Morphological Fidelity Prior (MFP) is introduced, leveraging semantic guidance from a pre-trained cell segmentation network to enforce boundary-preserving and region-aware reconstruction, thereby improving the representation of critical cellular boundaries and nuclear textures. Experiments on TCGA and SurGen datasets show that Morph-ISR achieves the best LPIPS and ST-LPIPS among the evaluated methods, reducing them by up to 38.37% and 39.55%, respectively, over the second-best methods while maintaining strong PSNR and SSIM. These results demonstrate superior preservation of diagnostically relevant cellular boundaries and nuclear textures, while compact parameterization and high throughput support efficient edge deployment. Code and trained models will be released upon publication.

Jiaming Liang, QiHui Han, Haolin Chen +5

School of Computer Science and Engineering, South China University of Technology, Guangzhou, China · School of Software Engineering, South China University of Technology, Guangzhou, China · School of Future Technology, South China University of Technology, Guangzhou, China +1

Computational Pathology Implicit Neural Representations Medical Image Super-Resolution Image Super-Resolution

Aug 4, 2026cs.CV

S $^3$ -Diff: Structural Semantic Synergy Diffusion Model for High Fidelity Super Resolution of Pathological Images

Digital pathology relies on high-resolution whole slide images for accurate diagnosis, yet limitations in imaging devices, storage, and transmission often make lower-resolution pathology images more common in clinical workflows. Current super-resolution techniques often tend to smooth diagnostically relevant morphology, leading to over-smoothed textures and semantic drift that compromise downstream clinical interpretation. To this end, we develop the Structural Semantic Synergy Diffusion Model (S3-Diff), a diffusion framework for high-fidelity super-resolution of pathological images. The core of S3-Diff is Specimen-aware Structural Anchoring (SSA), which combines prognosis-aware tissue support extracted by a fixed SAM with LR-HR gradient discrepancies to generate a specimen-specific structural anchor to preserve pathological morphology. Concurrently, we introduce Structure-guided Semantic Fidelity Tuning (SSFT) to adapt DINOv3 representations using SSA-derived structural supervision. SSFT combines the adapted semantic energy with LR-derived edge and grayscale cues. The resulting control guides denoising to suppress stochastic artifacts and maintain structural consistency. Extensive experimental results demonstrate that S3-Diff consistently outperforms state-of-the-art methods in both reconstruction quality and downstream survival analysis performance. The source code will be made public.

Jiaming Liang, QiHui Han, Guangye Ou +6

South China University of Technology Software Engineering Guangzhou, China · South China University of Technology School of Future Technology Guangzhou, China

Computational Pathology Diffusion Models for Image Restoration Medical Image Super-Resolution Whole-Slide Image Analysis

Jul 22, 2026cs.CV

SIINR: Structurally Informed Implicit Neural Representations for super-resolution with uncertainty quantification of clinical quality diffusion MRI datasets

Diffusion Magnetic Resonance Imaging (dMRI) is a powerful tool for probing brain microstructure, but clinical acquisitions are often limited by low out-of-plane resolution, resulting in degraded structural information and reduced utility for advanced analysis. We introduce SIINR (Structurally Informed Implicit Neural Representations), a general framework for super-resoltion of clinical dMRI datasets while quantifying uncertainty in the reconstructed outputs. SIINR utilizes a supervised 3D U-net as a prior and combines it with a self-supervised implicit neural representation (INR) that fuses the high-resolution prior and the original low-resolution data. The INR enables joint modeling across spatial and angular domains, enforces data consistency, and provides analytic approximate posterior distributions for downstream uncertainty quantification. We validate the framework on a diverse set of open-access dMRI datasets, demonstrating that SIINR outperforms standard interpolation methods in both quantitative error metrics and qualitative anatomical fidelity. Experiments on clinical cases, including subjects with multiple sclerosis and brain lesions, illustrate the framework its ability to propagate intensity changes and flag uncertain regions in challenging scenarios. SIINR is flexible, modular, and can be adapted to different upsampling ratios and downstream tasks, providing a principled approach for enhancing clinical dMRI and supporting robust interpretation of derived neuroimaging metrics.

Tom Hendriks, William Consagra, Anna Vilanova +2

Department of Computer Science and Mathematics, Eindhoven University of Technology, Groene Loper 5, Eindhoven, 5612 AP, Noord-Brabant, The Netherlands. · Department of Statistics, University of South Carolina, Columbia, 29225, South Carolina, United States of America. · Psychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, 399 Revolution Drive, Boston, 02215, MA, United States.

Implicit Neural Representations Uncertainty Quantification Medical Image Super-Resolution Magnetic Resonance Imaging Diffusion MRI Neuroimaging

Jul 18, 2026cs.CV

DRIFT: Difficulty-aware Rectified Flows for Through-plane MRI Super-Resolution

Magnetic Resonance Imaging (MRI) is often acquired with anisotropic resolution to reduce scan time, producing stair-step artifacts along the through-plane direction. In through-plane MRI super-resolution, an efficiency-fidelity trade-off arises: feed-forward regressors are fast but oversmooth at large slice-thicknesses, while sampling-based methods improve fidelity at high inference cost. We propose DRIFT, a two-stage thickness-conditioned rectified flow framework for through-plane MRI super-resolution with continuous input slice-thickness. Stage 1 employs an Anatomical Projection Network (APN) to map low-resolution patches to a coarse high-resolution manifold, providing a deterministic anatomical initialization that shortens the residual transport of Stage 2 and stabilizes slice-wise refinement. Stage 2 refines details via rectified flow and introduces a Physics-Aware Difficulty (PAD) metric derived from slice-thickness induced through-plane bandwidth deficit to guide an Adaptive Integration Scheduler (AIS), allocating ODE steps by thickness. A Consistent Endpoint Trajectory Alignment (CETA) loss enforces thickness-consistent reconstructions. Experiments show that DRIFT outperforms super-resolution baselines while reducing inference cost. Code, models, and interactive demos are available at https://yoonseokchoi-ai.github.io/drift-eccv2026/.

Yoonseok Choi, Eun-Gyu Ha, Daniel Kim +3

Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea · Department of Bioengineering, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran, Saudi Arabia · Electrical Engineering and Computer Science, University of California at Merced, Merced, USA

Rectified Flow Medical Image Super-Resolution Magnetic Resonance Imaging Adaptive Sampling

Jul 8, 2026cs.CV

Cardiac MRI Through-Plane Super-Resolution Guided by Reference and Memory

Clinical cardiac MRI is commonly acquired with high in-plane resolution but coarse through-plane resolution to reduce scan time and accommodate breath-hold and cardiac-motion constraints, which limits 3D analysis and diagnostic accuracy. We propose STRMSR, a reference- and memory-guided through-plane super-resolution (SR) framework that reconstructs high-resolution (HR) cardiac volumes by leveraging HR reference views acquired from the same subject and intermediate SR results as the memory. Our method uses coarse-to-fine contextual matching to establish robust correspondence between low-resolution target and reference/memory images under spatial misalignment. A learnable patch-wise dynamic feature aggregation module predicts content-adaptive mixture weights for each local patch, effectively fusing dynamic information while suppressing unreliable feature transfers. The intermediate SR results stored in the memory bank ensure slice-to-slice consistency for the super-resolved 3D volume. Experiments on the WHS cardiac MRI dataset under two reference protocols, orthogonal-plane views and long-axis chamber views, demonstrate consistent improvements over baselines at 4x and 8x upsampling factors.

Shaoming Pan, Chenchuhui Hu, Leon Axel +1

University of Texas at Arlington · University of Texas At Arlington · New York University Grossman School of Medicine

3D Medical Imaging Medical Image Super-Resolution Cardiac MRI Image Super-Resolution

Jul 7, 2026cs.CV

PhyMRI-SR: Toward Physics-Aware MRI Image Super-Resolution

Magnetic resonance imaging (MRI) super-resolution is vital for improving diagnostic accessibility, yet most methods treat it as a deterministic mapping from a fixed low-resolution input to a high-resolution target. This overlooks a key property of MRI acquisition physics: spatial resolution and signal-to-noise ratio (SNR) are inherently coupled, making any given low-resolution scan merely one of many possible realizations under varying acquisition trade-offs. We rethink MRI super-resolution as a physics-aware reconstruction problem, in which the goal is to identify the optimal resolution-SNR configuration and then super-resolve it to obtain high-quality MRI results. A key implication of this formulation is that MRI resolution becomes dynamic rather than fixed. To handle such resolution-heterogeneous inputs, we adapt 2D Gaussian Splatting (2D GS) to MRI by formulating reconstruction as a coordinate-based, resolution-agnostic rendering problem. To further enhance fidelity, we introduce three innovations: (1) a prior-aware Gaussian representation that combines an Anatomical Structure Prior for tissue-specific kernel initialization with an Imaging System Prior that captures hardware characteristics via a covariance dictionary; (2) a physics-constrained signal modeling scheme that predicts intrinsic tissue parameters (proton density rho and effective relaxation rate R2) and synthesizes intensities through governing physical equations, ensuring biophysically plausible contrast; and (3) a meta-learning framework that alleviates paired-data scarcity by pretraining on simulated data and adapting to real-world conditions. Extensive experiments on dynamic-resolution datasets and standard benchmarks demonstrate that our method achieves state-of-the-art performance, highlighting its strong potential for clinical deployment.

Lihua Wei, Huatong Gao, Jia Gong +4

Medical Image Super-Resolution Magnetic Resonance Imaging Physics-Informed ML Gaussian Splatting

Jun 25, 2026eess.IV

Dual-Prior Guided Null-Space Learning with Mixture-of-Splines for Arbitrary Medical Slice Super-Resolution

Arbitrary slice super-resolution reconstructs isotropic volumes from anisotropic clinical acquisitions by synthesizing intermediate slices at arbitrary scales. However, treating this ill-posed inverse problem as unconstrained residual-based regression risks hallucinating anatomically implausible structures or altering the originally observed data. To address both concerns, this paper presents the Dual-Prior Null-space Learning (DP-NSL) framework, which reformulates the task as a constrained recovery process guided by two complementary priors. A Measurement-Consistent Projection (MCP) enforces a Deterministic Observation Prior: the reconstruction undergoes an exact orthogonal projection that reproduces every acquired slice with zero error, confining all learned details to the unobservable null space. Within this null space, a Mixture-of-Splines (MoS) module imposes a Geometric Continuity Prior by dynamically mixing B-spline experts of different analytic orders, allowing each anatomical region to be modeled with a content-aware level of continuity. To promote spatial coherence, a Local Spatial Consistency Decoder (LSCD) further injects local inductive bias. Experiments on three CT and one MRI benchmark show that DP-NSL outperforms existing approaches while strictly preserving measurement consistency. Code is available at https://github.com/DeepMed-Lab-ECNU/Medical-Image-Reconstruction.

Haofei Song, Siyuan Xu, Xintian Mao +3

Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai 200241, China

Image Reconstruction Medical Image Super-Resolution Inverse Problems Image Super-Resolution Image Inverse Problems

Jun 24, 2026cs.CV

Cross-Modality Structural Guidance in 3D Latent Diffusion for Robust FLAIR Super-Resolution

High-resolution (HR) MRI acquisition is often hampered by scan time constraints, resulting in anisotropic or low-resolution scans (e.g., thick-slice FLAIR) that limit diagnostic accuracy. While deep learning-based super-resolution (SR) methods show promise, they often hallucinate anatomical details, which can compromise brain structural integrity. To mitigate this limitation, we introduce MR-DiffuSR, a Multi-Resolution Diffusion-based Super-Resolution framework that incorporates HR T1w structural image priors to guide the restoration of thick-slice FLAIR scans and operates in the 3D latent space. Our architecture introduces cross-modality structural swin-attention, which derives structural attention maps from the HR T1w and applies them to the low-resolution FLAIR latent features. This design disentangles anatomical structure from modality-specific contrast, effectively preventing hallucinations. Furthermore, we employ a mixed-scale degradation strategy, training the model on a continuum of downsampling factors to ensure robustness to varying slice thicknesses, while optimizing with a DINOv3-based perceptual loss to preserve high-frequency semantic details. Evaluated on the ADNI-4 dataset, MR-DiffuSR surpasses both CNN and 2D diffusion approaches, achieving an average PSNR of 32.46dB, SSIM of 0.97, and LPIPS of 0.07 across all downsampling factors. In downstream white matter hyperintensity segmentation, our model demonstrates exceptional robustness. While baseline performance collapses at 10x down-sampling (Dice: 0.51), MR-DiffuSR maintains a Dice score of 0.63, preserving utility even at 7mm equivalent slice thickness.

Haoyu Lan, Jiazhen Zhang, John Onofrey +4

University of Southern California · Yale University

Diffusion Models for Image Restoration Medical Image Super-Resolution Magnetic Resonance Imaging Diffusion MRI Image Super-Resolution

Jun 14, 2026cs.CV

CRIS: Cross-Plane Self-Supervised Isotropic Restoration for Anisotropic Volumetric Imaging Across Modalities

Anisotropic volumetric acquisitions are common in clinical MRI and volume electron microscopy (vEM), where sparse through-plane sampling creates thick slices or sections that degrade orthogonal reformats and downstream analysis. We present CRIS, a cross-plane self-supervised framework for isotropic restoration without paired isotropic ground truth. CRIS casts 3D restoration as 2D stripe completion on orthogonal reformats of an isotropic grid: high-resolution in-plane slices are synthetically degraded and periodically masked for training, while at inference blank slices define the isotropic grid, two orthogonal reformats are restored, and predictions are fused by multi-view averaging. We evaluate CRIS on two MRI cohorts and two microscopy benchmarks up to 8x anisotropy. On brain MRI, CRIS achieves 32.921 +/- 0.436 dB PSNR and 0.963 +/- 0.003 SSIM, outperforming interpolation, ECLARE, SMORE4, SIMPLE, SA-INR, and ATME, and gives the best segmentation consistency (Dice 0.940 +/- 0.004, ASSD 0.245 +/- 0.014 mm, HD99 1.275 +/- 0.061 mm). On reference-free abdominal MRI, CRIS reduces FID/KID to 48.71/0.023, outperforming interpolation, ECLARE, SMORE4, and SIMPLE. On vEM, CRIS achieves 29.100 dB/0.830 3D PSNR/SSIM at 4x and 26.874 dB/0.722 at 8x on EPFL, and 21.935 +/- 0.437 dB/0.696 +/- 0.024 on noisy hemibrain data. In a dedicated robustness experiment, one variable-gap CRIS model evaluated across gap factors 3-7 and coronal, axial, and sagittal degradations maintained higher PSNR/SSIM than interpolation (36.36-31.14 dB and 0.977-0.932 vs. 33.07-27.85 dB and 0.951-0.853). These results support CRIS as a modality-flexible route to isotropic restoration without paired isotropic targets or configuration-specific retraining. Code is available at https://github.com/adi-hatav/CRIS.

Adi Ahituv, Anat Ilivitzki, Moti Freiman

Faculty of Data and Decision Sciences, Technion – Israel Institute of Technology, Haifa, 3200003, Israel · Rambam Health Care Campus, Haifa, 3109601, Israel · Faculty of Biomedical Engineering, Technion – Israel Institute of Technology, Haifa, 3200003, Israel +1

Self-Supervised Learning Medical Image Super-Resolution Magnetic Resonance Imaging Image Restoration Microscopy Image Analysis

Jun 8, 2026eess.IV

Deep Slice Interpolation for Reducing Through-Plane Anisotropy and Noise in Head CT

Head computed tomography (CT) typically uses sub-millimeter in-plane resolution but 2-5 mm through-plane spacing, creating substantial anisotropy that degrades multiplanar reconstructions, volumetric measurements such as hematoma volume estimation, and downstream algorithms that assume near-isotropic voxels. We present a deep learning system that synthesizes intermediate CT slices from pairs of neighboring axial slices, halving the effective through-plane spacing. The system improves three-dimensional visualization while simultaneously producing inherently denoised outputs, yielding two complementary benefits from a single inference pass. To build a reliable system, we systematically evaluate pixel-wise losses, namely mean squared error (MSE) and mean absolute error (L1); structural-similarity losses, namely the structural similarity index (SSIM) and its multi-scale variant (MS-SSIM); and hybrid combinations. On a held-out test set, all converged models outperform classical interpolation baselines and pretrained video frame interpolation methods (RIFE, FILM) on all structural measures, with MS-SSIM+L1 offering the strongest balanced profile. We also document training instability in SSIM-family losses and identify partial remedies: the standard numerical fixes eliminate the dominant failure mode but leave residual divergence at smaller batch sizes. All results are reported with patient-level bootstrap confidence intervals and paired statistical tests. As an illustration, we apply the system to an out-of-distribution head CT series from Hospital Universitario Virgen del Rocío: the model synthesizes intermediate slices and exhibits on the real slices the implicit-denoising signature predicted by our theoretical analysis, supporting in a single external case that interpolation quality and implicit denoising are not confined to the training distribution.

Luis Cortés Ferre, Miguel A. Gutiérrez-Naranjo, Marcin Balcerzyk

Department of Computer Science and Artificial Intelligence, University of Seville, Avda. Reina Mercedes s/n, 41012 Sevilla, Spain · Bioaraba Health Research Institute, New Technologies and Information Systems in Health Research Group, 01009 Vitoria-Gasteiz, Spain · IKERBASQUE, Basque Foundation of Science, Plaza Euskadi 5, 48009 Bilbao, Spain

3D Medical Imaging Medical Image Super-Resolution Computational Imaging Computed Tomography

May 23, 2026cs.CV

ULF-Synth: Physics-Guided Ultra-Low-Field MRI Enhancement for Pediatric Neuroimaging

Ultra-low-field (ULF) MRI offers portable and accessible neuroimaging but suffers from reduced signal-to-noise ratio and limited spatial resolution compared to high-field (HF) systems. Acquiring paired ULF-HF data for supervised enhancement is often difficult, particularly in resource-limited settings. We introduce ULF-Synth, a framework that combines: (i) acquisition-based synthesis of realistic ULF images from HF volumes to create large-scale paired training data, (ii) a spatial-frequency domain objective that prioritizes recovery of high-frequency anatomical detail. This formulation is architecture-agnostic, consistently improving structural similarity and perceptual fidelity across encoder-decoder, adversarial, and diffusion-based translation models. When trained exclusively on synthetic data, the resulting models generalize effectively to real 64mT ULF acquisitions, improving downstream multiclass brain segmentation and achieving higher radiologist preference and diagnostic acceptability in a blinded reader study. These findings demonstrate that synthetic paired supervision provides a practical and scalable pathway for enhancing ULF MRI without requiring real paired acquisitions. Code, Models and Dataset: https://github.com/toufiqmusah/ULF-Synth

Toufiq Musah, Salvatore Calcagno, Federica Proietto Salanitri +3

Kwame Nkrumah University of Science and Technology, Kumasi, Ghana · University of Catania, Catania, Italy · The Hong Kong University of Science and Technology, Hong Kong SAR, China +1

Medical Image Super-Resolution Magnetic Resonance Imaging Medical Image Synthesis Neuroimaging

May 15, 2026eess.IV

Deep Learning for MRI Slice Interpolation: The Critical Role of Problem Formulation

Through-plane resolution in clinical MRI is typically much coarser than in-plane resolution, limiting diagnostic utility. This work investigates deep learning approaches to interpolate intermediate MRI slices in prostate imaging, effectively doubling through-plane resolution. I evaluated five architectures (CNN, U-Net, two GAN variants, and DDPM) and discovered that problem formulation has dramatically more impact than architectural complexity. By reformulating the interpolation task to use adjacent slices (i-1, i+1) rather than distant slices (i-2, i+2), I achieved a 58% improvement in SSIM performance across all deterministic architectures. The U-Net model achieved the best results with PSNR of 30.08 dB and SSIM of 0.898, representing a 10.1% improvement over linear interpolation baseline. A DDPM was also evaluated but showed poor reconstruction quality due to fundamental mismatch between stochastic generation and deterministic reconstruction requirements. These findings demonstrate that problem formulation can have 290x more impact than architectural sophistication in medical imaging tasks.

Shamit Savant

University of Florida, Gainesville, FL 32611, USA

Medical Image Super-Resolution Magnetic Resonance Imaging

May 15, 2026eess.IV

Layer Selection in Feature-Based Losses Affects Image Quality and Microstructural Consistency in Deep Learning Super-Resolution of Brain Diffusion MRI

Clinical application of high-resolution diffusion MRI is hindered by hardware limitations and prohibitive scan times, motivating computational super-resolution. This study investigates the efficacy of a feature-based loss function in preserving diffusion signal consistency in deep learning super-resolution. Using 7T data from the human connectome project to generate pairs of low- and high-resolution diffusion weighted images (DWI), we trained UNets for 2D super-resolution. Ablation and isolation studies evaluated different VGG16-layers for feature-based losses against an image-based L1 baseline. Deeper layers and combinations thereof resulted in grid-like artifacts in super-resolution DWIs, which persisted in diffusion parameters like quantitative and fractional anisotropy. No such artifacts were present when using the shallowest layer. Downstream analysis for this layer showed great consistency with the ground truth, even for 9-fold super-resolution. Image SNR and used VGG16-layer depths modulated artifact appearance and severity, mandating careful selection of contributing layers for application in and beyond diffusion MRI.

David Lohr, Rene Werner

Institue for Applied Medical Informatics, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany · Institute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany · Center for Biomedical Artificial Intelligence (bAIome), University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany

Perceptual Loss Medical Image Super-Resolution Magnetic Resonance Imaging Diffusion MRI

May 8, 2026cs.CV

NeuroGAN-3D: Enhancing Intrinsic Functional Brain Networks via High-Fidelity 3D Generative Super-Resolution

Recent advances in neuroimaging have deepened our understanding of the brain's complex functional and structural organization. Among these, functional Magnetic Resonance Imaging (fMRI) - particularly resting-state fMRI (rs-fMRI) - has emerged as a tool for identifying biomarkers of intrinsic brain connectivity and delineating large-scale neural networks. These networks are typically represented as volumetric spatial maps that capture functionally coherent brain regions and reflect individual differences in brain activity and structure. The spatial resolution of these maps plays an important role, as it determines the ability to localize functional units with precision, perform reliable brain parcellation, and detect subtle, spatially specific neurobiological alterations associated with development, aging, or disease. Therefore, improving the effective resolution of neuroimaging-derived maps holds significant promise for enabling more detailed insights into brain architecture and its relationship to behavior and pathology. To address this need, we propose NeuroGAN-3D, a novel 3D generative super-resolution model tailored to the computational demands of volumetric neuroimaging. Our model leverages a generative adversarial network architecture to enhance the spatial resolution of rs-fMRI spatial maps, significantly outperforming a conventional baseline.

M. Moein Esfahani, Sepehr Salem Ghahfarokhi, Mohammed Alser +2

1 2 Georgia State University, Atlanta, GA, USA · 2 1 Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA

3D Medical Imaging Medical Image Super-Resolution Neuroimaging Generative Adversarial Networks

May 5, 2026cs.CV

MedSR-Vision: Deep Learning Framework for Multi-Domain Medical Image Super-Resolution

Medical image super-resolution (MedSR) is essential for improving diagnostic precision across diverse imaging modalities such as MRI, CT, X-ray, Ultrasound, and Fundus imaging. Despite rapid advances in deep learning, challenges remain in preserving anatomical accuracy, maintaining perceptual quality, and generalizing across medical domains. This paper presents MedSR-Vision, a novel unified deep learning framework for evaluating and comparing super-resolution models across five modalities: Brain MRI, Chest X-ray, Renal Ultrasound, Nephrolithiasis CT, and Spine MRI, at magnification scales of

\times2

,

\times3

, and

\times4

. Three representative models namely SRCNN, SwinIR, and Real-ESRGAN are benchmarked using multiple quantitative metrics encompassing fidelity, perceptual realism, and sharpness. Experimental analysis demonstrates that Real-ESRGAN achieves superior perceptual quality and edge recovery at higher scales, SwinIR excels in preserving structural and diagnostic features, and SRCNN provides efficient and stable performance at lower magnifications. The results establish domain-specific insights and practical guidelines for model selection in clinical imaging workflows, offering a standardized evaluation framework for future medical image super-resolution research and deployment.

Subhash Gurappa, Trivikram Satharasi, Yashas Hariprasad +1

Knight Foundation School of Computing and Information Sciences Florida International University Miami, FL 33199, USA · University of Florida Gainesville, FL 32611, USA · Department of Computer Science California State University, East Bay Hayward, CA 94542, USA

Medical Image Super-Resolution Medical Image Benchmarks

May 4, 2026cs.CV

Self-Supervised Spatial And Zero-Shot Angular Super-Resolution by Spatial-Angular Implicit Representation For Rotating-View SNR-Efficient Diffusion MRI

Rotating-view thick-slice acquisition is highly SNR-efficient for mesoscale diffusion MRI (dMRI) but requires numerous rotating views to satisfy Nyquist sampling, resulting in long scan time. We propose a self-supervised Spatial-Angular Implicit Neural Representation (SA-INR) that reconstructs high-resolution dMRI from a single view per diffusion direction, representing a massive acceleration. Our model, an MLP conditioned on a b=0 structural prior and the b-direction via FiLM, is trained end-to-end on the anisotropic input. The framework not only accurately reconstructs the trained b-directions (spatial SR) but also learns a continuous q-space representation, enabling high-fidelity "zero-shot" synthesis of unseen b-directions (angular SR). On simulated data, our method achieved high fidelity for both trained (34.82 dB) and unseen (33.08 dB) directions. Most importantly, the synthesized angular data also improved the quantitative accuracy of downstream DTI model fitting. Our SA-INR framework breaks the classical sampling limits, paving the way for fast, quantitative high-resolution dMRI.

Yinzhe Wu, Hongyu Rui, Fanwen Wang +3

Department of Bioengineering and I-X, Imperial College London, London, UK · Cardiovascular Research Centre, Royal Brompton Hospital, London, UK

Implicit Neural Representations Medical Image Super-Resolution Magnetic Resonance Imaging Diffusion MRI

Apr 20, 2026cs.CV

CAHAL: Clinically Applicable resolution enHAncement for Low-resolution MRI scans

Large-scale automated morphometric analysis of brain MRI is limited by the thick-slice, anisotropic acquisitions prevalent in routine clinical practice. Existing generative super-resolution (SR) methods produce visually compelling isotropic volumes but often introduce anatomical hallucinations, systematic volumetric overestimation, and structural distortions that compromise downstream quantitative analysis and diagnostic safety. To address this, we propose CAHAL (Clinically Applicable resolution enHAncement for Low-resolution MRI scans), a hallucination-robust, physics-informed resolution enhancement framework that operates directly in the patient's native acquisition space. CAHAL employs a deterministic bivariate Mixture of Experts (MoE) architecture routing each input through specialised residual 3D U-Net experts conditioned on both volumetric resolution and acquisition anisotropy, two independent descriptors of clinical MRI acquisition. Experts are optimised with a composite loss combining edge-penalised spatial reconstruction, Fourier-domain spectral coherence matching, and a segmentation-guided semantic consistency constraint. Training pairs are generated on-the-fly via physics-based degradation sampled from a large-scale real-world database, ensuring robust generalisation. Validated on T1-weighted and FLAIR sequences against generative baselines, CAHAL achieves state-of-the-art results, improving the best related methods in terms of accuracy and efficiency.

Sergio Morell-Ortega, Ángela González-Cebrián, Boris Mansencal +8

Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain · CNRS, Univ. Bordeaux, Bordeaux INP, LABRI, UMR5800, in2brain, F-33400 Talence, France · Department of Psychobiology, Faculty of Psychology, Universitat de Valencia, Valencia, Spain +6

Medical Image Super-Resolution Brain MRI

Apr 20, 2026cs.CV

Trustworthy Endoscopic Super-Resolution

Super-resolution (SR) models are attracting growing interest for enhancing minimally invasive surgery and diagnostic videos under hardware constraints. However, valid concerns remain regarding the introduction of hallucinated structures and amplified noise, limiting their reliability in safety-critical settings. We propose a direct and practical framework to make SR systems more trustworthy by identifying where reconstructions are likely to fail. Our approach integrates a lightweight error-prediction network that operates on intermediate representations to estimate pixel-wise reconstruction error. The module is computationally efficient and low-latency, making it suitable for real-time deployment. We convert these predictions into operational failure decisions by constructing Conformal Failure Masks (CFM), which localize regions where the SR output should not be trusted. Built on conformal risk control principles, our method provides theoretical guarantees for controlling both the tolerated error limit and the miscoverage in detected failures. We evaluate our approach on image and video SR, demonstrating its effectiveness in detecting unreliable reconstructions in endoscopic and robotic surgery settings. To our knowledge, this is the first study to provide a model-agnostic, theoretically grounded approach to improving the safety of real-time endoscopic image SR.

Julio Silva-Rodríguez, Ender Konukoglu

Computer Vision Lab, ETH Zurich, Zurich, Switzerland

Medical Image Super-Resolution Video Super-Resolution

Apr 20, 2026cs.CV

Structure-Adaptive Sparse Diffusion in Voxel Space for 3D Medical Image Enhancement

Three-dimensional (3D) medical image enhancement, including denoising and super-resolution, is critical for clinical diagnosis in CT, PET, and MRI. Although diffusion models have shown remarkable success in 2D medical imaging, scaling them to high-resolution 3D volumes remains computationally prohibitive due to lengthy diffusion trajectories over high-dimensional volumetric data. We observe that in conditional enhancement, strong anatomical priors in the degraded input render dense noise schedules largely redundant. Leveraging this insight, we propose a sparse voxel-space diffusion framework that trains and samples on a compact set of uniformly subsampled timesteps. The network predicts clean data directly on the data manifold, supervised in velocity space for stable gradient scaling. A lightweight Structure-aware Trajectory Modulation (STM) module recalibrates time embeddings at each network block based on local anatomical content, enabling structure-adaptive denoising over the shared sparse schedule. Operating directly in voxel space, our framework preserves fine anatomical detail without lossy compression while achieving up to

10\times

training acceleration. Experiments on four datasets spanning CT, PET, and MRI demonstrate state-of-the-art performance on both denoising and super-resolution tasks. Our code is publicly available at: https://github.com/mirthAI/sparse-3d-diffusion.

Hongxu Jiang, Fei Li, Boxiao Yu +4

Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL, USA · Department of Medicine, University of Florida, Gainesville, FL, USA · Department of Biomedical Engineering, University of Florida, Gainesville, FL +2

3D Medical Imaging Medical Image Super-Resolution Diffusion Model Acceleration Diffusion Models Image Denoising

Mar 10, 2026cs.CV

UniField: A Unified Field-Aware MRI Enhancement Framework

Magnetic Resonance Imaging (MRI) field-strength enhancement holds immense value for both clinical diagnostics and advanced research. However, existing methods typically focus on isolated enhancement tasks, such as specific 64mT-to-3T or 3T-to-7T transitions using limited subject cohorts, thereby failing to exploit the shared degradation patterns inherent across different field strengths and severely restricting model generalization. To address this challenge, we propose \methodname, a unified framework integrating multiple modalities and enhancement tasks to mutually promote representation learning by exploiting these shared degradation characteristics. Specifically, our main contributions are threefold. Firstly, to overcome MRI data scarcity and capture continuous anatomical structures, \methodname departs from conventional methods that treat 3D MRI volumes as independent 2D slices. Instead, we directly exploit comprehensive 3D volumetric information by leveraging pre-trained 3D foundation models, thereby embedding generalized and robust structural representations to significantly boost enhancement performance. In addition, to mitigate the spectral bias of mainstream flow-matching models that often over-smooth high-frequency details, we explicitly incorporate the physical mechanisms of magnetic fields to introduce a Field-Aware Spectral Rectification Mechanism (FASRM), tailoring customized spectral corrections to distinct field strengths. Finally, to resolve the fundamental data bottleneck, we organize and publicly release a comprehensive paired multi-field MRI dataset, which is an order of magnitude larger than existing datasets. Extensive experiments demonstrate our method's superiority over state-of-the-art approaches, achieving an average improvement of approximately 1.81 dB in PSNR and 9.47% in SSIM. Codes and datasets are available at: https://github.com/linyiyang98/UniField.

Yiyang Lin, Chenhui Wang, Zhihao Peng +1

Department of Electronic Engineering, the Chinese University of Hong Kong · The Institute of Science and Technology for Brain-inspired Intelligence, Fudan University

Medical Image Super-Resolution Magnetic Resonance Imaging