Multi-Agent Orchestration

Enterprise Resource Planning (ERP) systems record transactions reliably but still delegate almost all operational decision-making to human specialists, because classical rule-based automation cannot reason about exceptions and monolithic AI assistants degrade when asked to coordinate across functional boundaries. This paper presents Agentic ERP, an expert-system architecture that combines role-aligned large-language-model (LLM) agents with a risk-tiered human-in-the-loop harness and a graph-based orchestrator to execute end-to-end business workflows on a production ERP backend. First, autonomous ERP operation is formulated as a constrained sequential-decision problem over a structured enterprise state, with a decomposition argument linking role-aligned agents to a measurable reduction in per-step tool-selection complexity. Second, a graph-based Planner--Executor--Reflector--Responder orchestration decouples generation from evaluation through externalised grading criteria and sprint contracts, packaging recent harness-engineering principles as inspectable expert-system artefacts. Third, the system is evaluated at three levels: a scenario-based task suite, a comprehensive comparison of six orchestration paradigms on cross-functional crisis tasks, and a 365-day agent-in-the-loop simulation against rule-based RPA and no-intervention baselines. Across these levels the proposed multi-agent method is significantly better than the baseline, and the system sustains a simulated year of operation with zero stockouts while the rule-based baseline accumulates hundreds under the same demand stream. The work shows that role-aligned LLM agents under human oversight can move an ERP system from passively recording transactions to actively executing operational decisions, and it provides a reference architecture and an evaluation protocol for autonomous enterprise resource planning.

Multi-agent systems (MAS) coordinate multiple LLM-powered agents through structured workflows, gaining reasoning power but incurring high inference latency from multi-step execution and repeated model invocations. Existing orchestration methods primarily optimize task performance and inference cost, leaving latency largely unaddressed. In MAS, end-to-end latency is governed by the critical execution path, so reducing total cost alone does not reliably reduce latency. Moreover, optimizing latency while preserving accuracy remains non-trivial: naive latency optimization can misassign operator-level credit and degrade task accuracy. To address this gap, we propose Latency-Aware Multi-agent System (LAMaS), a latency-aware orchestration framework for learning-based multi-agent systems. LAMaS addresses this challenge at two levels: at training time, it learns latency-aware execution graphs through constrained optimization with critical-path-aware credit assignment; at inference time, since a graph committed at training time cannot exploit runtime evidence, it complements graph construction with a lightweight controller that adaptively eliminates redundant future agent interactions as execution unfolds. Experiments on four benchmarks show that LAMaS achieves the best latency among evaluated learning-based MAS baselines, reducing end-to-end latency by over 50% while maintaining competitive or better accuracy. LAMaS is also modular and transfers to other MAS with minimal changes, consistently yielding latency reductions.

The paper introduces the Internet of Agentic Things (IoAT), an architectural framework that integrates agentic AI, IoT, cyber-physical systems, Physical AI, edge computing, and digital twins into a unified closed-loop orchestration framework. The proposed architecture consists of cloud, edge/fog, and physical IoT layers connected through autonomous AI agents that perceive, reason, coordinate, and actuate across distributed cyber-physical environments. The paper formalizes IoAT as a coupled workflow-control problem with nested strategic and tactical decision making using a hylomorphic dynamic programming framework that links agentic planning with physical execution. Smart-building orchestration is presented as a representative use case, and key research challenges related to safety, security, governance, resilience, and trustworthy deployment are discussed.

Large language model (LLM)-based web search agents are transforming information seeking from simple factoid question answering into complex, deep-and-wide search and research-oriented tasks. A single ReAct-style agent is constrained by one long trajectory and limited context, making it difficult to handle depth and coverage simultaneously. Existing multi-agent systems improve search coverage through parallel execution and aggregation, but still exhibit clear limitations in recursive depth, collaboration adaptability, and evidence-grounded expansion. We propose WebSwarm, a progressive recursive delegation framework that jointly constructs task decomposition, recursive expansion, and agent collaboration during inference. WebSwarm dynamically instantiates agentic search nodes, each coupling a local objective with a search mode that specifies how the node should organize search and collaboration. Each node can either solve its objective itself or further delegate child nodes; after solving, it returns evidence and results upward, enabling parent nodes to further expand, revise, or aggregate the search process. To guide this process, WebSwarm first probes how task-relevant information is organized on the web to ground subsequent node expansion, and reuses process-level experience across homogeneous sibling nodes. Experiments on BrowseComp-Plus, WideSearch, DeepWideSearch, and GISA show that WebSwarm consistently outperforms single-agent and multi-agent baselines on deep, wide, and interleaved deep-and-wide tasks. Further analyses of ablation, task difficulty, web tool efficiency, and model generalization explain WebSwarm's effectiveness and provide insights for multi-agent search systems.

Recent LLM-based mathematical reasoning agents have begun to tackle research-level problems and, in several cases, have contributed to the resolution of open problems. However, scaling and orchestrating such agents effectively remains challenging, due to the difficulty of coordinating parallel proof search while keeping intermediate claims organized and reliable. In this paper, we propose Danus, an orchestration system for research-level mathematical reasoning centered on a shared fact graph as a global memory-management mechanism. Danus consists of a main agent that performs planning and coordination, multiple worker agents that carry out proof search in parallel, and a stateless verifier that checks proposed mathematical claims before they are admitted into the fact graph. Each verified fact is stored together with its proof and logical dependencies, allowing the system to build long arguments incrementally while keeping the shared proof state organized. The main agent periodically summarizes the evolving proof state, redirects workers across promising directions, and supports interaction with human mathematicians through progress reports. We evaluate Danus through six research-level case studies in algebraic geometry, singularity theory, and combinatorics, illustrating how the fact-graph memory mechanism enables Danus to construct long, detailed mathematical proofs. Our results suggest that fact-graph-based orchestration provides an effective route toward scaling mathematical reasoning agents for long-horizon research problems. Danus is open source at https://github.com/frenzymath/Danus.

We present a distributed, vendor-agnostic multi-MCP architecture for SDN-based automation and autonomous control of multi-vendor, multi-layer IPoDWDM networks. The framework enables E2E service lifecycle automation, closed-loop cross-layer control using GNPy model and optical telemetry, and is experimentally validated on a IPoDWDM testbed.

Agentic Business Process Management has gained momentum recently. The prospect is that the autonomy of AI agents, i.e., predominantly LLM-based agents, can be balanced with a certain level of robustness, tractability, and traceability through a combination with process technology. In this paper, we provide a classification framework for agentic orchestration options along properties such as task specificity, traceability and tractability, autonomy and reactivity, and correctness assurance and present qualitative decision criteria for realizations of different scenarios. We also provide metrics for the quantitative assessment of realization properties and show them through different agentic implementations of a predictive light sensing scenario. Altogether, this work aims at providing properties, criteria, and metrics for the design and implementation of agentic orchestrations and orchestration of agents.

The rapid emergence of LLM-based agentic frameworks has significantly reduced the cost of assembling multi-agent systems (MAS), enabling fast prototyping and exploration of agentic behaviors. However, systems built with current tooling remain ill-suited for reliable, evolvable, and production-grade deployment. In practice, MAS are often developed in an ad-hoc and imperative manner, with agent logic, orchestration, observability, and control tightly interwoven, little to no explicit system-level validation, and development workflows optimized for demonstrations rather than long-lived, governed operation. As a result, behavior observed during experimentation rarely constitutes reliable evidence of behavior in production. In this paper, we introduce MAS-Lab, a specification-driven framework for principled development and experimental validation of multi-agent systems properties. MAS-Lab is designed to transform MAS from collections of scripts into engineered distributed systems by separating semantic intent from operational concerns, making behavior and control explicit, supporting reproducible experimentation, and preserving continuity across lifecycle stages. MAS-Lab consists of three layers: a declarative, framework-agnostic agentic specification layer (Spec); a stateful MAS Operating System that provides execution and control primitives plugged-in by design (MAS-OS); and a set of lab overlays with integrated observability and evaluation tools (Labs). Together, these components enable intent-based validation, principled system evolution, and a seamless transition to production-grade MAS.

Existing autonomous research agents can support parts of the research process, but most systems still treat research as either an isolated assistant task or a closed workflow. Therefore, autonomous science needs a collaboration infrastructure that coordinates projects, agents, and digital and physical resources. We identify this as a shift from code-centered execution loops to research-oriented collaboration processes, where questions, evidence, participants, and resources must be coordinated under uncertainty. In this framing, an agent may be an AI system, a human researcher, a team, a laboratory, or an organization-backed participant. To this end, we present Clarus, a collaboration infrastructure for coordinating autonomous research agents toward web-scale scientific collaboration. Clarus reformulates research as an open, auditable, attributable, and resource-aware multi-phase collaboration process. It defines a minimal project-agent-resource object model and organizes scientific collaboration through four layers including Research Application, Digital Collaboration, Physical Substrate, and Physical World. Core modules are implemented as pluggable mechanisms, allowing Clarus to adapt to task risk, collaboration structure, and resource constraints. Through a controlled paper-generation case study, we show that Clarus can organize a research goal into a traceable, reviewable, attributable, and accumulative collaboration network across phases, tasks, and participants. Together, the object model, collaboration protocol, trust mechanisms, and prototype validation provide an initial foundation for open research networks. Clarus is now available at clarus.holosai.io.

Operations Research (OR) provides a rigorous framework for high-stakes decision-making, but effective OR modeling requires substantial domain knowledge, mathematical abstraction, and solver expertise. Recent LLM-based systems automate parts of this pipeline, yet remain limited by low accuracy on complex problems, opaque outputs, and narrow solver support. We propose COOPA (COoperative OPerations Agent), a modular LLM-agent architecture for interpretable and scalable OR decision support. It combines three components: iterative confidence-based modeling, which generates multiple candidate formulations, self-evaluates them across modeling dimensions, and selects one using a max-min confidence criterion; element-level provenance and confidence explanations, which link variables, parameters, constraints, and objectives to quoted source text and provide an audit trail for human verification; and multi-solver routing to specialized optimizer agents for different OR problem classes. Across three OR benchmarks, eight LLM backbones, and four baselines under identical conditions, COOPA achieves the best macro-average accuracy on six of eight backbones and improves over the strongest baseline by up to 6.7 percentage points. A within-system ablation isolates the contribution of iterative confidence-based modeling, while additional analyses and case studies illustrate the value of source traceability and multi-solver dispatch.

Agentic systems are changing how complex operational tasks are coordinated, introducing a new paradigm for connecting heterogeneous data sources and automating processes. Electric bus fleets provide a relevant test case. Their operation requires continuous coordination between service reliability, battery state-of-charge, charger availability, electricity prices, route-energy uncertainty, and vehicle-to-grid (V2G) opportunities. This paper proposes an agentic aggregator framework that streamlines this decision environment by coupling an optimization-based electric bus scheduling model with supervisory agents for disturbance detection, tariff adaptation, and schedule evaluation. The optimization core enforces physical feasibility across routes, chargers, batteries, and V2G exchanges, while the agentic layer interprets changing operating conditions, triggers real-time re-optimization when needed, and defines how flexibility value is allocated between the aggregator and the public transport operator (PTO). A realistic depot case study evaluates day-ahead and real-time operations under profit-based and operation-based coordination modes, considering service delays, route-energy deviations, electricity price shocks, and combined disturbances. The results show that agentic aggregation can support adaptive fleet-grid coordination by maintaining feasible schedules, activating re-optimization selectively, and improving the use of charging and V2G flexibility. However, they also reveal a critical trade-off: the same agentic capability that reduces operational complexity can extract value from the PTO when configured around profit-oriented pricing. These findings suggest that agentic aggregators can become useful for managing electric bus V2G operations, but their deployment in public-fleet contexts requires transparent coordination modes, auditable tariff-setting, and explicit value-sharing rules.

Biomedical researchers increasingly use AI-generated analyses and reports to interpret protein-level signals, but static outputs are often insufficient for research decision-making, where users need to inspect evidence, assess uncertainty, compare mechanisms, and refine hypotheses. We present \textsc{BioInsight}, a multi-agent system that moves from static biomedical report generation to interactive evidence-centered interactive interface generation. Given a disease name, a protein association table, and optional cohort metadata, BioInsight organizes disease-specific evidence through typed intermediate artifacts, including ranked pathways, literature evidence packets, protein-level reasoning notes, citation-grounded reports, dashboard schemas, and rendered interactive interfaces. The system decomposes evidence retrieval from mechanistic reasoning, normalizes citations through deterministic components, and converts the same structured evidence used in the report into an interactive interface. We evaluate BioInsight on standardized biomedical QA, challenging protein-function reasoning, and end-to-end biomedical evidence synthesis. Results show that BioInsight achieves best, and suggest that biomedical AI systems should move beyond text-only and static reports toward provenance-preserving, interactive evidence artifacts.

Real-world computer-use tasks often span multiple applications and devices, requiring agents to coordinate heterogeneous environments under dynamic runtime failures. Existing multi-device agent systems support task decomposition and cross-device assignment, but recovery remains largely coarse-grained: when execution fails, they typically retry the same strategy, reassign the subtask, or revise the global plan, without systematically modeling the device-local strategy space. This limits their ability to distinguish failures that can be repaired within the current device from those that require cross-device replanning. We propose \textbf{H-RePlan}, a hierarchical replanning framework for multi-device agents with unified API--CLI--GUI execution. H-RePlan equips each device with interchangeable execution strategies and separates device-local strategy recovery from orchestrator-level global replanning through a compact cross-layer failure abstraction. To evaluate this capability, we introduce \textbf{HeraBench}, a fault-injected benchmark that constructs cross-device workflows over Linux and Android devices and injects strategy- and device-level failures. Experiments show that H-RePlan substantially outperforms single-strategy and coarse-grained multi-device baselines, achieving higher completion, instruction adherence, and perfect-pass rates while reducing the token cost required for reliable end-to-end success. These results demonstrate that scope-aware hierarchical recovery is essential for robust multi-device agent execution.

Enterprise agent language models must coordinate specialist agents over continuous business event streams, yet most multi-agent evaluations assume discrete request-response workflows. We present a controlled simulation based on a sanitized enterprise research snapshot: 208 scenarios, 393 events, and 1,051 expected agent calls across Persona (<10 agents), Department (20-80), and Enterprise (200) registries. We compare DAG Plan & Execute with ReAct and evaluate a minimal Task Manager for priority inference, related-event merging, and preemption. Both systems perform well on the Persona cohort but score lower on the Enterprise cohort, especially for Simple scenarios; a larger, more confusable discovery space may contribute. The tested DAG Plan & Execute implementation generally maintains higher agent-call precision, whereas ReAct shows stronger recall and Expected Answer Completeness in several Enterprise conditions. The Task Manager reduces high-priority queue latency by 14-75% and improves related-event Expected Answer Completeness by over 20 percentage points at Enterprise scale. These controlled-simulation results characterize the tested systems but do not establish production readiness.

While LLM-powered agents offer end-to-end automation for industrial asset lifecycles, real-world Industry 4.0 deployment is hindered by latency, concurrency instability, and safety risks. We present DynAMO (Dynamic Asset Management Orchestration), a deployment-ready engine using a Plan-then-Execute architecture to generate verifiable workflow graphs. DynAMO supports both SequentialWorkflow (topological execution) and ParallelWorkflow (dependency-aware concurrency). By dynamically identifying independent tasks, DynAMO preserves structural correctness and safety while significantly improving efficiency through controlled reasoning overlap. Across six controlled experiments on the AssetOpsBench industrial benchmark, DynAMO demonstrates substantial performance and robustness gains. Parallel execution reduces end-to-end latency by a median of 1.6x over sequential orchestration, rising to 1.8x on highly parallelizable workflows. After instrumenting external tool calls with realistic latencies, a latency decomposition shows that LLM reasoning and orchestration still account for more than 90% of execution time, identifying model inference as the primary system bottleneck. Structured context pruning reduces inference latency by approximately 30%, and DynAMO maintains correct functional behaviour (task completion, agent sequencing, and output quality) while exhibiting graceful degradation under controlled fault injection. Reproducibility analysis further confirms stable execution under repeated runs, with parallel scheduling reducing latency variance. These findings establish DynAMO as a practical blueprint for scalable, safe, and latency-aware agent deployment in Industry 4.0 automation pipelines. Code is available at: https://github.com/kushwaha001/DynAMO

The real-time orchestration of microgrids that combine fluctuating renewable sources, dispatchable units, storage and curtailable consumers requires the repeated solution of combinatorial dispatch and coalition formation problems under hard control deadlines. In this paper, a quantum-assisted agentic distributed artificial intelligence (DAI) framework is proposed in which the dispatch problem of each control slot is formulated as a quadratic unconstrained binary optimization (QUBO) problem by Belief-Desire-Intention extended (BDIx) agents and is solved by a portfolio of quantum, quantum-inspired and classical solvers. Solver selection is elevated to a first-class agentic deliberation action of the coordinator agent. Learned beliefs about solver latencies are maintained and the solver intention that is expected to satisfy the prevailing deliberation deadline is committed in each slot. In addition, a belief-shaped storage valuation mechanism is introduced through which the storage agent prices its energy at a discounted future-peak value, injecting intertemporal information into the otherwise myopic per-slot optimization. The framework is evaluated on a 24-hour simulation of a grid-connected microgrid with photovoltaic, wind, battery, genset and demand-response assets, with the Quantum Approximate Optimization Algorithm (QAOA) executed by statevector simulation and benchmarked per slot against tabu search, simulated annealing, binary particle swarm optimization, greedy descent and exhaustive enumeration. Zero deliberation deadlines are missed, the committed dispatch attains the exact optimum on every slot and the realized daily cost of 146.24 EUR equals the exact lower bound, with 97.83 percent renewable utilization and zero unserved energy. When the storage valuation mechanism is deactivated, the daily cost is increased to 152.75 EUR, a 4.5 percent increase.

Multi-Agent Systems (MAS) built on Large Language Models (LLMs) require effective orchestration to coordinate specialized agents, yet training such orchestrators is hindered by limited supervision and high computational cost. We propose Orchestration Reward Modeling (OrchRM), a self-supervised framework for evaluating orchestration quality without human annotations. OrchRM leverages intermediate artifacts from multi-agent executions to construct win-lose pairs for Bradley-Terry reward model training. Unlike existing MAS test-time scaling and orchestrator training frameworks that rely on costly sub-agent rollouts, OrchRM operates directly at the orchestration level, enabling efficient and high-performing reward-guided orchestrator training and MAS test-time scaling. OrchRM improves training efficiency by up to 10x in token usage while improving MAS test-time scaling performance by up to 8% in accuracy. These gains consistently transfer across multiple domains, including mathematical reasoning, web-based question answering, and multi-hop reasoning, demonstrating orchestration-level reward modeling as a scalable direction for robust multi-agent orchestration. Code will be available at https://github.com/Wang-ML-Lab/OrchRM.

The rapid emergence of autonomous AI agents is transforming artificial intelligence from isolated model inference into distributed systems of reasoning, communication, and action. This paper develops the vision of the Internet of Agentic AI (IoAI): an open ecosystem in which heterogeneous agents discover one another, negotiate responsibilities, exchange context, invoke tools, and execute workflows across cloud, edge, device, organizational, and cyber-physical environments. We synthesize foundations from single-agent agentic AI, multi-agent systems, distributed computing, communication networks, game theory, and security engineering to characterize the architectures and mechanisms required for scalable agent ecosystems. The paper examines agent deployment models, workflow lifecycles, communication protocols, interoperability layers, resource-management challenges, and trust architectures, with case studies in adaptive manufacturing and distributed operational coordination. The resulting framework highlights the central research challenges of controlled emergence, semantic interoperability, secure identity, incentive-compatible coordination, resource-aware orchestration, and governance for large-scale networks of autonomous agents.

LLM-based multi-agent systems increasingly coordinate planning, reasoning, tool use, and human interaction, yet their reliability remains limited. A central source of this limitation is the underspecified prompt--harness boundary. Current systems lack a principled way to decide which workflow commitments should remain in prompts and which should become harness structure. We present \textbf{XFlow}, an executable protocol programming system for reliable multi-agent workflows, and \textbf{XPF} (XFlow Protocol Format), its domain-specific protocol programming language. XFlow occupies a middle position between prompt-only orchestration and markup-like workflow descriptions. XPF remains readable as a literate protocol, but it is compiled and executed as a program. Its design keeps informal semantic work inside actors while moving selected commitments into harness structure that can be checked, preserved, and enforced. At runtime, XFlow stages uncertainty through lifecycle-governed symbols, which are typed state cells with validation and commit states. Actor outputs are mediated before they become shared state, instead of spreading through prompts, transcripts, or implicit memory. Our experiments cover Constrained Interaction, Long-Context Reasoning, and Agentic Software Engineering. They show that XFlow improves reliability by making constraints, evidence handling, and process requirements explicit and enforceable.

Arbor is a multi-agent framework that introduces structured tree search as a cognition layer for autonomous agents operating in large, stateful action spaces. Prior autonomous optimization systems operate on isolated targets with stateless evaluation. Arbor instead maintains an explicit search tree of scored hypotheses that serves as the shared working memory across agents, evolving with every measurement, treating failures as diagnostic signal that reshapes subsequent exploration, and expanding as prior successes shift the bottleneck distribution. We validate Arbor on full-stack LLM inference optimization, a domain where achieving peak performance has historically required coordinated effort from engineering teams across the application, framework, compiler, kernel, and hardware stack. Arbor pairs an Orchestrator agent, which drives optimization by delegating to Domain Specialists across the inference stack, with a Critic agent that safeguards stability through root-cause analysis, introspection, and measurement validation -- a checks-and-balances architecture where neither agent can unilaterally drive the system. Agent capabilities are decomposed into hard skills (domain expertise) and soft skills (coordination protocols that determine how contributions compose), enabling fully autonomous multi-day campaigns. Arbor achieves up to 193% inference throughput-latency Pareto improvement over vendor-optimized baselines, while a single agent without the harness plateaus at +33% throughput improvement and crashes irrecoverably within hours. Arbor generalizes to multiple generations of hardware platform, and run-to-run variance is within 2 percentage points demonstrating that the method is hardware-agnostic and reproducible.

Existing multi-agent LLM orchestration methods, ranging from brute-force ensembles to learned routers, select models and topologies based on task and model features. However, these methods do not consider the runtime state of the serving infrastructure. On shared GPU clusters under concurrent load, this infrastructure blindness causes systematic resource underutilization: preferred models accumulate deep request queues while equally capable alternatives sit idle. In multi-agent pipelines, where each query triggers multiple sequential model calls, these delays then compound across every downstream step. Closing this gap is challenging because the relevant infrastructure signals (queue depths, KV-cache pressure, latencies) are dynamic and noisy, and they must drive three different decisions: planning, per-step routing, and scheduling. We introduce INFRAMIND, a framework that makes the entire multi-agent stack infrastructure-aware. An infra-aware planner conditions topology and role selection on real-time system load and remaining budget, biasing toward simpler graphs under congestion and richer ones at low load. An infra-aware executor then observes per-model queue depths, cache utilization, and response latencies at each agent step to decide which model to call and how deeply to reason; a budget-aware scheduler further reorders each model's queue so that urgent requests are served first. Cast as a hierarchical constrained MDP and solved end-to-end via reinforcement learning, the system learns to balance quality against latency automatically. Across five benchmarks, INFRAMIND delivers up to +7.6 pp accuracy over the prior baseline at low load with up to 7x lower latency, and sustains up to 99.9% SLO compliance under high load where every baseline drops below 50%.

Cloud network infrastructure at hyperscale presents unique operational challenges where traditional human-driven incident response cannot keep pace with the volume, velocity, and complexity of failures. This paper presents an agentic AI architecture for autonomous incident resolution in large-scale network operations. Our system employs a multi-agent orchestration framework where specialized AI agents collaborate to detect, diagnose, and remediate network incidents without human intervention. We describe the architectural principles, including hierarchical agent decomposition, skills-based tool invocation via standardized protocols, structured knowledge encoding from operational runbooks, progressive autonomy with safety boundaries, and closed-loop verification. The architecture has been deployed in production at a major cloud provider, demonstrating that agentic AI systems can achieve autonomous resolution rates exceeding 90% for common incident categories while maintaining safety guarantees through layered authorization and rollback mechanisms. We discuss design tradeoffs, failure modes, and lessons learned from operating autonomous AI agents at scale.

Real-world LLM applications are moving beyond single-agent workflows toward orchestrated multi-agent systems, yet current models still struggle to determine what each sub-agent needs to know. To measure this, we introduce PerspectiveGap, a benchmark for evaluating LLMs' ability to compose orchestration prompts for multi-agent systems. PerspectiveGap contains 110 scenarios, each evaluated through two distractor-mixed task formats: role-fragment assignment and free-form prompt writing. These scenarios are organized into 10 topologies, which are distilled from the authors' real-world engineering practice and framed by the Prompt Economy principle: building loop-centered orchestrations that maximize utility with minimal role and engineering overhead. In experiments with 33 commercial models from 10 companies, GPT-5.5 substantially outperforms all competitors, whereas Opus 4.8 shows a notable weakness in orchestration prompting despite its strong coding performance. Nevertheless, PerspectiveGap remains challenging: the evaluated models achieve an average combined pass rate of only 17.2% (GPT-5.5 62.0%) and an average overall leakage rate of 217.9% (a per-scenario information leak-event count, not a proportion; GPT-5.5 49.1%). These findings suggest that multi-agent orchestration prompting is a distinct and under-evaluated capability, and PerspectiveGap provides a foundation for measuring and improving it systematically.

Regulatory review of advanced nuclear reactor designs routinely spans more than three years and consumes hundreds of millions of dollars in combined regulator and applicant labor. We present the Regulatory Context Protocol (RCP), an Agent-to-Agent communication standard that replaces the formal human-to-human pipeline between regulators and applicants with a structured, auditable agentic channel, while preserving human oversight at safety-significant decision points. The protocol is calibrated against an analysis of 1,236 documents from U.S. Nuclear Regulatory Commission advanced reactor dockets and demonstrated with a working multi-agent pilot. Against an 89M USD, 42-month Reconstructed Baseline, RCP cuts costs by 50-77 percent (21M-44M USD) and timelines by 65 percent (15 months). Without a shared protocol, Standalone Agents reach only 54M-74M USD and 21 months. The residual cost-and-time gap is structural, not algorithmic: it traces to the inter-organizational pipeline that only an agent-to-agent standard can compress. The same bottleneck - formal multi-party review under strict auditability requirements - characterizes pharmaceutical approvals, environmental permitting, financial supervision, and aviation certification. The US regulatory paperwork burden carries a 426.5 billion USD annual opportunity cost; replicated broadly, the projected 50-77 percent reduction implies savings on the order of 210-330 billion USD per year - approaching 1 percent of US GDP.

Enterprise agent systems increasingly need to connect large language models to private tools, internal knowledge, and Model Context Protocol (MCP) interfaces. In this setting, raw task capability is insufficient: organizations also require policy enforcement, tenant-scoped isolation, and execution that remains within explicit operational boundaries. We present Queen-Bee, a governed multi-agent architecture in which a Queen control plane retrieves capabilities, plans task-scoped execution, and compiles a structured BeeSpec that is executed by specialized Bee agents under constrained tool access. We implement a working prototype with tenant-scoped MCP connectors, audit-backed execution-time governance, retrieval-driven weak incubation, and multiple provisioning backends. We evaluate the system on 59 enterprise-style tasks spanning governance-sensitive requests, retrieval-driven provisioning, scoped local execution, and chemistry workflow integration. The retrieval-driven Queen-Bee variant achieves a task success rate of 0.964, zero governance failures, and substantially better scoped execution quality than both a static Queen-Bee baseline and a permissive single-agent baseline. We further show a multi-Bee chemistry workflow with explicit approval gating and a concrete top-3 shortlist grounded in real upstream evidence and screening artifacts. Additional comparisons with hybrid retrieval and LLM-guided provisioning show that richer provisioning backends are viable but do not outperform the lightweight structured retriever on the current small, highly structured capability registry. The results provide prototype-level systems evidence rather than a production deployment study, and suggest that enterprise agent platforms should be evaluated not only by capability, but also by governed provisioning, isolation behavior, scoped execution quality, and artifact-aware workflow coordination.

Multi-agent AI systems show promise for automating software engineering tasks, yet existing approaches suffer from coordination overhead, quality control gaps, and limited human oversight. We introduce SPOQ (Specialist Orchestrated Queuing), a methodology combining three innovations: (1) wave-based topological dispatch that computes parallel execution waves from task dependency graphs; (2) dual validation gates applying quality metrics before execution (planning validation) and after (code validation) to reduce rework cycles; and (3) Human-as-an-Agent (HaaA) integration, where a human specialist participates in decomposition and can be consulted during execution. SPOQ uses a three-tier agent hierarchy (Opus workers, Sonnet reviewers, Haiku investigators) to optimize cost-quality tradeoffs. We evaluate SPOQ through four experiments. Experiment 1: wave dispatch approaches the critical-path lower bound (ratio 1.03--1.11, speedup up to 14.3x); on a 2-slot local backend it delivers a stable 1.4x speedup. Experiment 2: SPOQ improves planning coverage from 93.0 to 99.75, eliminates cyclic plans, and lifts parallelism from 31.0 to 75.25. Experiment 3: dual validation reduces defects from 0.34 to 0.20 per task and lifts test pass rate from 91.25% to 99.75%. Experiment 4: human review reduces residual defects from 0.47 to 0.03 per task. Results are replicated on a locally hosted open-weights model (Qwen3.6-35B-A3B), verifying gains are attributable to orchestration rather than any specific model. A longitudinal study across 17 repositories, 8,589 commits, 1,822 tasks, and 13,866 tests (99.87% pass rate) provides ecological validation.

Software architecture design is a critical yet inherently complex and knowledge-intensive phase that requires balancing competing quality attributes and adapting to evolving requirements. Traditionally, this process has been time-consuming, labor-intensive, and heavily reliant on architects, often resulting in limited exploration of alternative architectural decompositions and styles, especially under the pressures of agile development. While LLM-based agents have shown promising performance across various software engineering tasks, their application to architecture design remains relatively scarce and requires systematic exploration. To address these challenges, we proposed MAAD (Multi-Agent Architecture Design), a knowledge-driven framework that orchestrates four specialized agents (i.e., Analyst, Modeler, Designer and Evaluator) to autonomously and collaboratively transform requirements specifications into comprehensive, multi-view architectural blueprints with quality attribute assessments. MAAD incorporates RAG to inject recognized architectural standards and patterns into the workflow and leverages a hierarchical memory mechanism that captures design history for iterative refinement. We evaluated MAAD through comparative experiments against MetaGPT, using quantitative architecture-level metrics across 10 case studies and qualitative feedback from industry architects on 10 real-world specifications. Results show that MAAD generates more complete, modular, and traceable architectures than the baseline, and its dedicated Evaluator agent autonomously produces structured quality evaluation reports that significantly reduce manual validation efforts. Furthermore, we found that the quality of the generated architecture heavily depends on the underlying LLM's reasoning capacity, with GPT-5.2 and Qwen3.5 outperforming other models across most evaluation settings.

Scientific discovery demands intelligence, perseverance, and serendipity across vast search spaces. Today, top scientific capabilities remain siloed--one AI system for biological analysis, another for clinical reasoning, mathematical derivation, or materials simulation--and no pre-designed team can anticipate every skill a question will need. Science Earth is a planet-scale scientific runtime in which any capability--a simulation cluster, a wet-lab robot, a proof engine, a single-cell pipeline--can connect to any other, with collaboration structure emerging from the question itself. Its underlying EACN protocol lets capabilities discover one another, negotiate task ownership, and adjudicate across incompatible evidentiary standards without prior knowledge of who will meet whom. This shifts the organizing challenge from workflow design to open-ended connectivity. Two runs validate this under structurally distinct conditions. In a trans-Pacific higher-order Kuramoto synchronization study, agents identified and corrected a closure-ratio assumption in Ott-Antonsen analytic theory that fails outside the Lorentzian limit, within thirty minutes. In an eight-agent single-cell run on the 4.88M-cell Kang 2024 pan-cancer atlas, heterogeneous capabilities coupled over a 64.9-hour window with one structural external instruction, producing three new result layers and anchoring findings against an independent wet-lab study on an adjacent CCR8- TIGIT+ Treg subset. These cases are a first empirical reading, not a benchmark sweep. They show that when AI capabilities are truly connectable and coordination emerges from the problem, scientific reasoning becomes a distributed, self-correcting process--a step towards scaling AI-native discovery to the planet.

Multi-agent Large Language Model (LLM) systems offer a way to decompose complex tasks, such as coding, through parallelization and context isolation. However, adding agents in practice introduces inter-agent communication overhead, which incurs extra cost and can sometimes offset the efficiency gains. We formalize multi-agent orchestration as a graph partitioning problem that captures the communication-to-computation trade-off: task decomposition can shorten critical-path computation, but cross-agent dependencies require costly context transfer. We instantiate this view in repository-level software engineering and present Cohesion-aware Coder (Co-Coder), which builds dependency graphs from static analysis, isolates structural hub files, partitions the graph via community detection, and executes the partition with a dependency-aware scheduler. Across 28 real-world tasks on DevEval and CodeProjectEval, Co-Coder advances the Pareto-frontier over sequential and file-based parallel baselines as well as Claude Code with Agent Teams, lifting pass rate by up to 14.0%, achieving up to a 2.10x wall-clock speedup, and reducing API cost by up to 35%, with the largest gains on the most dependency-dense projects. Co-coder demonstrates how cohesion-aware orchestration can make parallel coding agents both theoretically grounded and practically efficient, suggesting a broader design principle for multi-agent systems.

Enterprise multi-agent systems increasingly expose multiple coordination patterns, but deployments often lack evidence for when to use consensus, debate, synthesis, or a simpler single-agent workflow. This paper evaluates whether coordination strategy should be selected dynamically by problem class rather than fixed globally. We run a frozen matrix of 30 enterprise tasks spanning six industries, five problem classes, four execution conditions, three replications per cell, and four model arms: qwen_local, sonnet, gemma_openrouter, and an auxiliary openai cloud-validation arm. All 1,440 generated outputs are judged by a fixed Sonnet rubric. The main finding is bounded and operationally useful, but it is not the original strict H1. The pre-registered exact-winner/CI criterion is not supported: exact winner identity is unstable across model arms, and several predicted strategies are close to, but not above, the best observed alternative. A weaker near-best routing claim is strongly supported. In every pre-registered model arm and problem class, and again in the auxiliary OpenAI validation arm, the predicted strategy is within 0.10 quality-score points of the best observed condition. Structured compliance verification is the clearest exception to the original mapping: all arms favor single_agent rather than consensus. A pre-registered Kendall's W test finds no reliable difference between Vietnamese-domain and English-domain tasks in how consistently the four coordination conditions are ranked (mean W of 0.20 in both strata; signed-rank p = .85), so H2 is not supported. We conclude that enterprise coordination policy should use dynamic routing as a calibrated default, not as a deterministic winner-selection law.