Multimodal Alignment

Multi-modal image generation, particularly subject-driven customization, has garnered growing attention in recent years. Despite the rapid advancement of generative models, their evaluation remains largely lagging. Existing methods, whether embedding-based or Multi-modal Large Language Model (MLLM)-based, evaluate alignment with each modal condition in isolation, which contradicts the simultaneous condition alignment objective of multi-modal image generation, leading to poor consistency with human judgments. To address this challenge, we propose UFO, the first unified framework for omni-condition alignment simultaneous evaluation. Specifically, UFO introduces a novel Atomized Chain-of-Evaluation paradigm, \emph{i.e.}, it first decomposes omni-condition alignment into a sequential chain of fine-grained, disentangled Atomic Evaluation Units (AEUs), categorizes them into distinct modality-relevance classes, and then employs general or dedicated functional calls for accurate verification of different AEU types. Experimental results demonstrate that UFO achieves the highest correlation with human evaluation preferences, delivering an average improvement of 15.25%. Furthermore, we present UFO-Bench, a dedicated benchmark designed to holistically evaluate the performance of existing customization models under the diverse mutual interactions of textual and visual conditions.

Current text-to-image systems typically employ a "text encoder plus diffusion decoder" paradigm, in which text semantics directly modulate continuous latent noise. Despite their success, these methods lack an explicit, interpretable intermediate representation that effectively bridges high-level linguistic semantics and low-level visual signals. In this paper, we propose Vision-of-Thought (VoT), a framework that introduces a discrete visual-thinking layer between vision-language models (VLMs) and diffusion transformers (DiTs). Instead of treating VLMs merely as text encoders, we use them as multimodal planners that generate discrete VoT tokens representing high-level visual plans, such as objects and layouts, before rendering pixels. We train a specialized VoT tokenizer in the VLM semantic space with a closed-loop objective that combines VLM alignment, feature reconstruction, and vector-quantization losses. These objectives make the tokens semantically readable by the VLM while preserving the visual information needed for generation. Experimental results demonstrate that VoT improves semantic alignment and provides a structured interface for interpretable and controllable generation.

We study the problem of aligning data from multiple modalities into a shared representation space, focusing on settings where strong pretrained unimodal encoders are available but cross-modal paired data are scarce. We propose a structure-preserving alignment framework, joint kernel entropic Gromov--Wasserstein Optimal Transport (JK-EGW), which maps multiple modalities into a common latent space by minimizing a quadratic optimal transport objective. JK-EGW leverages fine-grained similarity relationships within and across modalities to construct a global affinity kernel instead of relying on raw feature-space distances. Our framework naturally provides explicit control over the geometry and distribution of the latent embedding. On the theory side, we establish parametric sample complexity rate of $n^{-1/2}$, matching the corresponding rates for standard, entropic and Gromov--Wasserstein optimal transport. On the algorithmic side, we derive a scalable alternating procedure to solve JK-EGW with entropic optimal transport (EOT) updates through a low-rank kernel approximation and a variational lifting. This lifting scheme effectively relieves the burden of a quadratic objective, and allowing us to take the advantage of existing EOT solvers. Empirically, we focus on post-hoc alignment of embeddings from pretrained encoders in data-scarce regimes, and show that our proposed method achieves improved multimodal retrieval performance compared to existing alignment baselines.

We propose Sen-Cap, a Sensor-Flexible and Noise-Resilient 3D human motion Capture framework that integrates multi-modal data from LiDAR and camera. While multi-modal sensors provide richer information than single-modal sensors, existing approaches still suffer from two core challenges. First, multi-modal alignment/matching across arbitrarily deployed sensors is typically handled by explicit calibration, which propagates errors under changing viewpoints and in turn constrains deployment to fixed, highly overlapped layouts. Second, prior methods degrade under severe noise or partial sensor failures, which are common in real-world environments. To address these challenges, Sen-Cap introduces a Unified Across-Sensor Motion Estimator that reconstructs local pose and shape in a human-centric space without calibrations between sensors, supporting a flexible number of sensors, as well as a Noise-Resistant Trajectory Tracker that maintains robustness under severe point cloud noise through iterative refinement. These sensor-flexible and noise-resilient features make Sen-Cap more practical in real-world deployment. Notably, operating in real time, Sen-Cap achieves state-of-the-art performance on major metrics on Human-M3 and FreeMotion, as well as strong cross-domain performance on LiDARHuman26M and RELI11D. This combination of flexibility and robustness opens new opportunities for motion capture in real-world scenarios, e.g. sports analytics, field robotics, and large-scale immersive environments.

Language model benchmarking is a difficult task. Outcome reasoning alone does not test the model's conceptualization of language and popular open-source benchmarks are quickly saturated or ingested as training data. It is important to test the model's output, but augmenting these tests by characterizing semantic structure gives more insight to how models relate abstract concepts. However, the high dimensional embedding spaces are not easy to interpret. This work demonstrates how topological methods can be used to rigorously compare these spaces to low dimensional and interpretable baselines like ontologies and curated knowledge graphs. These multi-modal alignment tests make it possible to track model adaptations and test phrase understanding across multiple languages.

Modern opaque AI models prize performance over interpretability, which makes testing difficult. However, formal statistical tests conducted on a model's embedding space can provide robust characterizations of semantic structure, concept separation, and knowledge graph alignment. Model developers would benefit from a model comparison technique that leverages human-curated knowledge structures to test alignment. The scale of the input space for even relatively simple tasks motivates the need for alignment checks that augment standard outcome reasoning. This work develops and demonstrates a topology-based multi-modal alignment test to make deployment, selection, and comparison of opaque models more interpretable. These methods also offer an intuitive connection to possibility theory and a unified decision theoretic framework from data to deployment.

In recent years, multi-view clustering has attracted widespread research interest. However, due to limitations in data collection devices, data across different views often suffer from misalignment, leading to the partial view alignment problem (PVAP). To mitigate the impact of view asymmetry and irrelevant samples, this paper proposes a framework for partial multi-view clustering via dual alignment and structure enhancement (DAS-PMVC), which leverages view structure consistency and semantic relevance. Specifically, DAS-PMVC includes three parts: \textbf{anchor graph structure alignment}, where sample joint embedding representations with consistent latent space are derived from anchor point relationships for initial view alignment; \textbf{structure-enhanced feature learning}, where the model learns view structure information through pretraining and combines multi-view graph convolutional networks to further extract deep latent features from the aligned graph structure to improve the discriminative power of representations; and \textbf{a dual alignment strategy}, where initial alignment is performed through the anchor graph in the pretraining phase, and contrastive learning loss and the Hungarian algorithm are introduced in the training phase to further optimize the alignment of latent features. Experimental results on various datasets demonstrate that the DAS-PMVC framework outperforms existing state-of-the-art methods in clustering performance, showcasing its effectiveness and superiority.

Multimodal Large Language Models (MLLMs) rely on a projector to align visual representations with the language embedding space, making it central to cross-modal understanding. In Multimodal Continual Instruction Tuning (MCIT), however, shifting visual distributions and evolving instruction semantics cause this shared projector to drift, leading to projector-level forgetting, an issue largely overlooked by methods that focus primarily on the LLM backbone. We introduce Progressive Multimodal Alignment (PMA), a framework that enables the projector to adapt continually while preserving previously learned alignment. PMA detects multimodal distribution shifts via a lightweight representation descriptor and progressively expands projector experts only when needed. An expandable router integrates expert outputs based on multimodal features, while the original pretrained projector is retained as a stable alignment anchor. This progressive mechanism balances stability and plasticity with sub-linear parameter growth and serves as a method-agnostic add-on to existing MCIT approaches. Extensive experiments on two recent MCIT benchmarks demonstrate that mitigating projector-level forgetting yields consistent gains over prior state-of-the-art methods when combined with PMA. Moreover, PMA scales across diverse MLLM backbones, demonstrating robust and broadly applicable MCIT performance.

Perception tasks for autonomous vehicles need to work satisfactorily in adverse weather conditions. Due to lack of real-world weather datasets, weather simulations are a promising alternative. To ensure simulations closely mirror real-world weather data, it's crucial that they represent the same weather characteristics, including severity and particle positioning, across different sensors. To achieve this, we propose the Reference Dataset Alignment Method (ReDAM) for weather intensity alignment in fog and Unified-weather-edit (inspired by Weather-edit[1]) for particle positioning alignment in rain and snow. We validate both alignment methods using statistical and geometrical tests, respectively. We find that 3D detection models for non-aligned versions tend to be overly optimistic as compared to aligned versions. We also show the aligned-multi-sensor simulation's effectiveness for achieving robustness for 3D object detection task by finetuning existing sensor fusion models on it.

Current identity customized video generation methodologies are predominantly limited to single-identity scenarios, as the lack of explicit identity separation mechanisms often leads to identity confusion in multi-identity settings. Existing multi-identity approaches, which directly extend single-identity frameworks by concatenating face images as input conditions, frequently result in unnatural facial expressions and motions, manifesting as the "copy-paste" phenomenon. To overcome these limitations, we introduce GroupVideo, a novel framework that leverages multiple individual photographs to generate identitycustomized video. Built upon Video Diffusion Transformers, GroupVideo incorporates multimodal identity alignment: visual alignment jointly encodes multiple face images to provide robust identity references, while semantic alignment introduces a semantic perceiver to enhance the naturalness of motions. An ID localization module with spatial guidance is introduced to address identity blending and enhance identity fidelity, along with bounding box constraints and mask regularization loss, to focus on facial regions and improve training efficiency. In response to the shortage of multi-ID video datasets, we have curated a comprehensive high-quality dataset of 20,000 videos, thereby establishing a crucial resource to advance future research in multi-ID video generation. Extensive experiments demonstrate that GroupVideo outperforms existing methods in generating multi-character videos with consistent identities and natural motions.

Backchannels, which signal listener states like empathy and understanding, are fundamental to natural human interaction. However, current approaches rely solely on audio and text. This omits crucial visual cues, such as facial expressions and gestures, as well as broader conversational contexts, which are necessary for accurate prediction. In this paper, we introduce Context-Aware Multimodal Alignment for Backchannel Prediction (CAMA-BC), a novel framework that leverages visual information through Multi-Layer Multimodal Alignment (MMA). Our alignment process comprises two stages. First, Context Alignment (MMA-CA) utilizes unlabeled dialogues with videos to capture conversational contexts. Next, Backchannel Alignment (MMA-BA) fine-tunes the representations specifically for backchannel prediction. Experimental results show that CAMA-BC significantly outperforms both existing methods and simple multimodal baselines, with particular effectiveness in recognizing complex backchannels such as empathy.

Contrastive learning is increasingly moving toward settings with three or more modalities instead of image-text pairs. Yet, extending models from pairwise to higher-order multimodal alignment can introduce optimization and representation challenges. We identify encoder Jacobian conditioning as a key factor in trimodal contrastive learning: poorly conditioned encoders exhibit collapsing or amplified singular-value spectra, leading to exploding Jacobian condition numbers and degraded multimodal alignment. We introduce geometry-preserving encoders (GPEs) by directly conditioning the Jacobian through regularization and demonstrating that simple modifications like LeakyReLU activations and residual paths recover these geometric benefits. Across a synthetic benchmark and four real-world datasets including missing modalities, improving Jacobian conditioning boosts retrieval and linear probe performance across multiple contrastive objectives, whereas expressive objectives yield little benefit in linear probes. More broadly, our results show that multimodal contrastive learning depends not only on objective expressivity, but also on the geometric and optimization properties of the underlying encoders.

Multimodal large language models (MLLMs) still struggle with spatial reasoning that requires perspective transformation. In particular, they often rely on camera-centric cues rather than reasoning from the reference object's viewpoint, leading to systematic errors in non-camera reference settings. In this paper, we first analyze this failure mode and show that object orientation is a key factor underlying such camera-centric shortcut behavior. To address this issue, we propose OrientSAM, an orientation-aware spatial alignment framework for multimodal models. OrientSAM injects explicit orientation information into multimodal representations through orientation-aware tokens and Fourier-based angle encoding, and further adopts a curriculum learning strategy to progressively improve perspective-aware reasoning. In addition, we build a spatial data construction pipeline to generate orientation-aware spatial supervision from large-scale images. Experiments on Spatial-MM, ViewSpatial, and 3DSRBench show that OrientSAM consistently outperforms strong baselines, especially on non-camera-view, person-centric, and orientation-sensitive tasks. The results further demonstrate that explicit orientation modeling is important for mitigating camera-centric shortcut behavior and enabling more robust allocentric spatial reasoning in multimodal models.

Multimodal-attributed graphs (MAGs), whose nodes carry modalities such as images and text alongside topological structure, now pervade applications including social platforms, e-commerce, and biomedical networks, offering richer semantic signals than single-modality graphs. In practice, such graphs are fragmented across privacy-restricted silos owned by different platforms and institutions, so learning a broadly transferable model over them demands collaborative training that never exposes raw data. This places the task at the intersection of multimodal graph learning and federated learning, yet existing methods cover only one side of it. To address the challenges from these two perspectives, we propose FedGAMMA, casting federated multimodal graph foundation learning as a two-stage semantic-structural alignment problem of federated pre-training and prompt-based fine-tuning. During pre-training, a shared-private semantic enhancer disentangles cross-modal commonality from modality-specific information, aligning it through optimal transport, a topology-aware graph fusion module decouples semantic and structural views via semantic residual graphs and dual positional encodings, and a dual-channel affinity-aware aggregation mechanism estimates client similarity from feature and graph centroids without exposing raw data. During fine-tuning, FedGAMMA adapts the pretrained encoder through lightweight graph-aware prompts, a shared prompt pool with controlled exploration, and channel-wise prompt synchronization. Experiments on twelve multimodal graph datasets show FedGAMMA consistently surpassing a broad range of baselines across downstream tasks, with gains of up to 12.96%. FedGAMMA further outperforms competitive baselines accross multi-domain datasets on multiple tasks with up to 5.71% under few-shot learning scenario.

Understanding music requires understanding localized relationships across data modalities, e.g., how time in performance audio maps onto position in a score image. Yet supervision for such local correspondences is difficult to obtain-in practice, we often only have access to coarser global supervision like paired segments of audio and images. To address this gap, we propose FuSiLi (Fused Sinkhorn-Localized Similarity), a similarity score for multimodal contrastive learning operating directly on local image patch and audio frame features via Sinkhorn-based soft alignment. We show that FuSiLi (i) effectively learns local relationships, (ii) requires only global supervision, and (iii) retains the global alignment capabilities of conventional contrastive approaches. We fine-tune pretrained CLIP and CLAP encoders on pairs of raw sheet music images and audio using a hybrid contrastive objective combining FuSiLi with conventional global similarity. We evaluate on cross-modal retrieval and frame-level alignment tasks against a range of global and local baselines, showing that our approach outperforms them on local alignment while remaining competitive on retrieval.

With the rapid advancement of aerospace embodied intelligence, enabling Unmanned Aerial Vehicles (UAVs) to autonomously understand and reason about complex environments has become increasingly important. However, existing UAV-based spatial reasoning approaches face critical limitations: single-view perception renders them vulnerable to occlusions and perspective distortions, while most VLMs lack explicit geometric modeling, relying on semantic cues and yielding inconsistent reasoning under viewpoint and scale variations. To address these challenges, we propose SatAgent, a UAV-Satellite collaborative spatial reasoning model inspired by the dual-pathway mechanism of the human visual system. By jointly leveraging satellite and UAV perspectives, SatAgent enables robust, accurate reasoning in complex urban environments. We first introduce a Geometric-Aware 3D Reconstruction Encoder that elevates 2D UAV features into explicit 3D spatial representations. Next, we design a multi-view topology-semantic alignment module integrating cross-view features within a unified BEV coordinate system. We further introduce a multi-view consistency loss encouraging viewpoint-invariant representations. Finally, we construct SatAgent-SR130K, the first large-scale UAV-Satellite collaborative multi-view spatial reasoning dataset. Experiments show SatAgent outperforms state-of-the-art general-purpose foundation models and specialized spatial reasoning models by 25.91% and 11.69%, respectively, across diverse tasks, achieving particularly high accuracy in complex geometric relationship reasoning.

H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability. We show that training a lightweight alignment module atop frozen histopathology and RNA-Seq foundation models enables open-vocabulary molecular prompting -- querying H&E slides with gene-set signatures to predict pathway activity without sequencing or end-to-end retraining. Using contrastive learning on a multi-cancer cohort (N=1,720), we achieve a 25-fold improvement in retrieval over baseline methods. Systematic analysis reveals a graduated predictability spectrum: morphologically grounded programs (cell-cycle programs, immune-related) are most reliably predicted (R^2>0.5), while predicting pathways with no morphological footprint remains challenging as expected. We validate clinical utility on the POSEIDON clinical trial: H&E-predicted squamous cell carcinoma scores recapitulate NSCLC subtype identity and predicted IFN-gamma mirror PD-L1 tumor-cell expression groups. Furthermore, genesets describing immune activation and fibrosis predict known tumor microenvironment archetypes from histology alone. We further validate generalization of our approach across unseen cohorts and demonstrate data-efficient domain adaptation, establishing a slide-native framework for molecular analysis on H&E images.

Morphological traits provide important evidence for phylogenetic reconstruction and evolutionary relationship analysis. Recent image-based approaches have introduced deep learning, particularly convolutional models, to derive morphological features from specimen images, but these methods generally rely on single-modality visual representations and do not explicitly incorporate morphological semantics. This study proposes a morphology-aware multimodal alignment framework for insect phylogenetic reconstruction. The framework combines specimen images with curated morphological descriptions by adapting a vision transformer through parameter-efficient fine-tuning and supervised contrastive learning, followed by image-text alignment in a shared latent space. The learned image embeddings are then used as continuous traits for Bayesian phylogenetic reconstruction. On the public Rove-Tree-11 dataset, comparative and ablation experiments across multiple visual backbones and feature adaptation strategies demonstrate that multimodal alignment improves topological agreement with the reference phylogeny. The results indicate that the proposed framework can derive morphology-aware visual traits for computational phylogenetic reconstruction.

Multimodal foundation models have advanced rapidly thanks to large optical benchmarks, but comparable resources for synthetic aperture radar (SAR) remain limited. Existing SAR--optical datasets largely rely on low-resolution, intensity-only Ground Range Detected~(GRD) products and do not preserve complex-valued SAR measurements or native acquisition geometry, which restricts physically grounded multimodal learning. In particular, large-scale public datasets combining very-high-resolution (VHR) SAR SLC, aligned optical imagery, and natural-language descriptions are still lacking. We present a VHR SAR--optical--text dataset built from open-access Umbra spotlight acquisitions distributed as Sensor Independent Complex Data (SICD). From around 2,500 worldwide scenes (VV/HH, 20cm--2m native resolution), we standardize all SAR data to an 80cm slant-range grid via band-limited FFT resampling and tile the imagery into 1024 by 1024 patches. For each SAR patch, we retrieve a high-resolution optical tile and warp it into the SAR grid using local coordinate correspondences for local pixel-level alignment. We further generate three caption variants (SHORT/MID/LONG) per sample to support vision--language training and evaluation. Our dataset contains 119,566 triplets (complex and amplitude slant-range SAR patch, aligned optical patch, natural-language description) covering 257 locations across 72 countries and a broad range of land types and infrastructures. We release fixed train/validation/test splits and the full preprocessing and baseline code to enable reproducible benchmarks for multimodal alignment on cross-modal retrieval and conditional generation in native SAR geometry. The dataset is publicly available on the Hugging Face Hub at https://huggingface.co/datasets/ONERA/SARLO-80.

Feature misalignment in BEV perception is a critical yet often overlooked challenge in autonomous driving, especially under calibration uncertainties between LiDAR and camera sensors. To address this issue, we propose a robust multi-modal fusion framework, GraphBEV++, which systematically mitigates projection-induced misalignment. The framework consists of two key modules: LocalAlign-v2 and GlobalAlign-v2. LocalAlign-v2 introduces neighborhood-aware depth features via graph matching to correct local misalignment. It supports both LSS-based and query-based BEV representations, making it compatible with BEVFusion and BEVFormer architectures for consistent cross-paradigm alignment. GlobalAlign-v2 encompasses two variants: Deformable and Diffusion. The Deformable variant addresses global misalignment in LSS-based multi-modal BEV by explicitly learning cross-modal feature offsets. In contrast, the Diffusion variant targets implicit misalignment in query-based BEV by injecting noise to simulate misalignment and employing a denoising process to recover aligned features. Experimental results show that GraphBEV++ achieves state-of-the-art performance under misalignment noise on nuScenes and Waymo subset, improves long-range detection on Argoverse2, and generalizes effectively to the 3D occupancy prediction task, consistently improving occupancy estimation accuracy and robustness under both clean and noisy settings. Furthermore, GraphBEV++ effectively alleviates misalignment issues in end-to-end autonomous driving. Compared with five baselines (UniAD, VAD, FusionAD, MomAD, and WoTE), it demonstrates superior performance in both open-loop (nuScenes) and closed-loop (Bench2Drive and NAVSIM) evaluations across perception, prediction, and planning tasks.

Glioma grading and survival prediction require the integration of heterogeneous information collected at different spatial and biological scales. Histopathology describes tissue morphology, mRNA expression captures molecular activity, and magnetic resonance imaging provides a non-invasive view of tumor extent and radiological heterogeneity. Existing glioma prognosis models often combine only two of these sources, while their alignment objectives remain mostly pairwise. This paper introduces GLORIA, a novel trimodal framework for GLioma Omics - Radiology - hIstopathology Alignment. GLORIA processes whole-slide image regions, gene-expression profiles, and 3D MRI volumes through modality-specific encoders, projects them into a shared latent space, and aligns them with a Gramian contrastive loss that measures the volume spanned by the three modality embeddings. The aligned representations are fused through a cross-modal gating module and optimized jointly for three-class glioma grading and overall survival prediction. We evaluate GLORIA on a matched TCGA-GBM/LGG and BraTS21 cohort, comprising 132 patients with all three modalities. On the shared trimodal test set, GLORIA improves over the bimodal WSI-mRNA baseline in all the metrics considered.

Robust self-supervised learning of multi-modal video representations is critical for real-world applications such as driver distraction detection, where multiple sensors provide complementary but noisy signals. Conventional contrastive objectives, such as InfoNCE, assume all negatives are equally informative and all positives are reliable. However, this assumption is frequently violated in multi-modal data due to viewpoint changes, occlusions, or semantic overlap across modalities. In this work, we propose a novel framework for multi-modal global alignment that addresses these challenges by jointly modeling faulty negatives and unreliable or faulty positives. We introduce soft targets derived from cycle-consistency scores to relax the hard-negative assumption, and a weighting mechanism based on similarity distributions to mitigate the impact of noisy or faulty positives. Our approach extends traditional pairwise alignment to a principled global multi-modal setting, aggregating alignment information across all modality pairs. We evaluate our method on the Drive&Act dataset, demonstrating that it consistently outperforms both pairwise and existing global alignment baselines across RGB, IR, Depth, and Skeleton modalities. Cross-view ablation studies further show strong generalization to unseen camera perspectives, highlighting the robustness of our representations. Overall, our framework provides a scalable and effective solution for self-supervised global multi-modal representation learning, enabling reliable driver distraction detection and pioneering in real-world multi-modal video understanding. Our code will be published on GitHub.

Open-set 3D recognition requires models that generalize to rare or unseen categories. Recent approaches address this by distilling language-vision knowledge into 3D encoders, typically relying on heavy 2D ViTs and aligning each point cloud with a single image or caption, thus anchoring representations to partial views. We propose aligning each point cloud with multiple images and textual descriptions to capture a more holistic understanding of 3D objects. To realize this idea, it is essential to design a loss function capable of jointly aligning a 3D instance with multiple matched signals, multi-view images and multiple texts, while separating positive aggregation from negative competition. We introduce such a function, termed the decoupled multi-positive contrastive loss. Our formulation enhances the loss's hardness-aware focus on challenging negatives, avoiding the "spotlight crowding" that occurs when many positives share the same softmax with all the negatives. Complementing this, we present a lightweight text adapter applied only to web captions, reducing the domain gap to curated annotations and enabling effective use of large-scale unsupervised text. Our model demonstrates state-of-the-art open-vocabulary performance on long-tail benchmarks, yielding substantial zero-shot improvements while sustaining high frame rates.

Multimodal neuroimaging fusion of functional MRI (fMRI) and diffusion tensor imaging (DTI) provides complementary information for cognitive impairment analysis, but remains challenged by heterogeneous feature spaces and misaligned representations. We propose \textit{NeuroAlign}, a hierarchical framework for structured multimodal fusion. It introduces (1) \textit{Dual-Modal Hierarchical Alignment} (DMHA), which models multi-scale dynamic connectivity and aligns dynamic-static and functional-structural embeddings; and (2) \textit{Dual-Domain Hierarchical Interaction} (DDHI), which enables fine-grained modulation and global interaction between connectivity- and region-level features. To support feature-level inspection, we design \textit{Synergistic Activation Mapping} (SAM), a gradient-free, marker-oriented attribution method for DFC, SFC, ALFF, and FA. Evaluated on GUTCM, ADNI, and OASIS under five-fold validation, NeuroAlign achieves competitive MCI/SCD detection and preliminary cross-dataset transferability. Attribution analyses reveal modality-specific and partially consistent brain patterns, providing model-derived evidence for multimodal representation analysis.

In recent years, emotion recognition based on physiological signals such as electroencephalogram (EEG) has gained considerable attention, as internal physiological data offer greater objectivity and reliability compared to external behavioral data like facial expressions. However, due to distribution shifts caused by individual and contextual differences, along with variations in sample quality across modalities, constructing a cross-domain multimodal emotion recognition model with high generalization and robustness remains a key challenge. In this study, we propose a Unified Framework with Adaptive Multimodal Alignment (UF-AMA) to address cross-subject and cross-session emotion recognition using multimodal physiological signals. First, we construct a cross-modal feature fusion network comprising Transformer encoders and multi-head cross-attention modules, enabling the deep integration of EEG signals and eye-tracking data. Subsequently, we introduce a confidence-aware screening mechanism that dynamically assesses the predictive reliability of each modality branch on target domain samples, partitions samples into different quality subsets, and accordingly applies global consistency alignment and cross-modal distillation. Finally, we propose a multi-level domain adaptation framework that jointly optimizes the marginal and conditional distributions of both local modality-specific and global fusion features, thereby reducing cross-domain distribution shifts at multiple granularities. Extensive experiments on the SEED and SEED-IV datasets demonstrate that UF-AMA achieves state-of-the-art (SOTA) performance in both cross-subject and cross-session tasks. The source code is available at: https://github.com/BetterCoderLab/UF-AMA.

Contrastive learning is effective for aligning paired views or modalities, but alignment beyond two modalities remains non-trivial and comparatively underexplored. Pairwise CLIP-style losses decompose multi-modal alignment into independent two-way comparisons and therefore do not explicitly model higher-order dependencies among multiple modalities. Recent beyond-pairwise objectives approach this problem from statistical or geometric perspectives, but arbitrary-modality alignment still lacks a principled criterion for defining what each modality should preserve and compress relative to the others. We revisit arbitrary-modality alignment through the Information Bottleneck principle. In multi-modal learning, sufficiency should preserve information predictable from the remaining modalities, while minimality should compress modality-specific information not supported by them. This naturally leads to a One-vs-All view, where each modality is characterized with respect to the remaining modalities. We propose OVA-IB, an Information Bottleneck framework for arbitrary-modality alignment. OVA-IB optimizes a tractable One-vs-All contrastive lower bound for sufficiency connected to a Dual Total Correlation-style objective, uses a parameter-free geometry-aware projection score, and derives a tractable upper-bound regularizer for minimality by bounding each representation's dependence on its own input with representation distributions induced by the remaining modalities. Experiments on classification, regression, modality-agnostic evaluation, and cross-modal retrieval benchmarks demonstrate strong and robust performance.

Large language models (LLMs) have become increasingly useful computational models of human language processing, but it remains unclear whether vision-language learning makes text representations more human-like during natural reading. Here, we address this question by comparing tightly matched LLM and vision-language model (VLM) pairs under a strictly text-only setting, allowing us to isolate the effect of multimodal training history from online visual input or cross-modal fusion. We evaluate model alignment with a human natural-reading dataset that includes whole-cortex fMRI responses and synchronized eye-tracking saccades. Our findings demonstrate that multimodal pretraining may not confer a uniform, global advantage in human alignment during natural reading, indicating that language-internal representations remain the key factor for modeling human text processing. However, the VLM advantage could emerge more selectively when sentences contain stronger visual semantic content, with converging evidence from both fMRI and eye-movement alignments. Together, our findings provide a controlled in silico framework for testing how visual learning history shapes model-human alignment of language processing, suggesting that multimodal pretraining contributes selectively rather than globally to human-like language representations during natural reading.

Instruction tuning of large vision-language models (LVLMs) increasingly depends on massive multimodal corpora, yet these datasets contain samples with substantial redundancy, low visual dependency, and highly imbalanced coverage of multimodal reasoning behaviors. As a result, uniform subsampling or naive score-based selection often yields suboptimal training subsets. We introduce MAGIC, a training-free, forward-only coreset selection method designed to construct compact yet behaviorally faithful subsets for multimodal instruction tuning. MAGIC is built on three intrinsic signals extracted from a pretrained VLM: Multimodal Gain, which measures the likelihood improvement obtained from visual input; Bridging Relevance, which captures the sharpness of answer-token grounding over visual tokens; and Skill-Neuron Signatures, which characterize the functional computation elicited by each sample via top-activated feed-forward neurons. MAGIC combines these signals in a three-stage pipeline: filtering low-gain examples, ranking candidates by a normalized quality objective, and performing bucket-wise budget allocation over discrete neuron signatures to preserve latent multimodal skill coverage. This formulation avoids backpropagation, auxiliary selector training, and expensive clustering in continuous activation spaces, while remaining efficient and easily deployable in existing VLMs. Across LLaVA-665K and Vision-Flan datasets, and transfer settings to large target models, LLaVA-1.5-7B and -13B, MAGIC consistently improves over strong baselines under matched 20% budgets: it achieves 100.3% relative performance to full finetuning on LLaVA-665K and 101.6% relative performance on Vision-Flan-186K, while yielding a 73.7% reduction in wall-clock run time.

Multimodal alignment is critical for bridging the semantic gap in information retrieval. However, traditional pairwise strategies introduce a geometric blind spot: while they align anchor modalities (e.g., text) with others, they lack constraints to enforce mutual consistency between peripheral modalities (e.g., video and audio). The TRIANGLE framework addresses this by minimizing the area of modality triplets on a hypersphere to enforce holistic alignment. In this reproducibility study, we verify the robustness of this geometric objective for retrieval tasks. We confirm that TRIANGLE outperforms pairwise baselines in zero-shot settings, achieving Recall@1 gains of up to +8.7 points, though benefits are domain-dependent. However, we fail to reproduce the reported learning-from-scratch results. Analysis using a synthetic toy dataset attributes this to instability when jointly optimizing geometric alignment with Data-Text Matching (DTM) loss. Furthermore, we find that cosine regularization primarily stabilizes text-to-video retrieval, and fine-tuning with domain supervision amplifies geometric benefits but reduces cross-dataset generalization. Our findings support the efficacy of geometric alignment while highlighting critical optimization sensitivities. Code available at https://github.com/ARIJIT00171/RE-TRIANGLE.

Flow matching based video generative models have been increasingly relying on prepended Vision-Language Models (VLMs) to handle complex, instruction-based video editing. The prevailing assumption underlying this paradigm is that a connector module can seamlessly align the VLM's rich multi-modal reasoning with the original text embedding space of DiTs. However, we hypothesize that this alignment acts as a severe semantic bottleneck, degrading fine-grained structural variables. Verifying this is challenging, as end-to-end evaluations conflate alignment failures with generation errors, and natural datasets lack disentangled annotations. To rigorously investigate this, we propose a controlled data processing pipeline based on video composition that results in TRACE-Edit, a diagnostic dataset focusing on relation-based editing. Leveraging this dataset, we propose a comprehensive diagnostic protocol to analyze two important designs of meta-query and connector in the existing video editing models. Systematic evaluation of four representative model cases reveals that fine-grained structural semantics can be severely degraded during alignment. Our findings overturn the assumption of lossless semantic transfer, identifying the VLM-to-DiT alignment as a major bottleneck and providing a new diagnostic foundation for future multi-modal alignment architectures.

Multimodal representation alignment is pivotal for large language models and robotics. Traditional methods are often hindered by cross-modal information discrepancies and data scarcity, leading to suboptimal alignment spaces that overlook modality-unique features. We propose CodeBind, a framework that optimizes multimodal representation spaces through a modality-shared-specific codebook design. By incrementally aligning target and bridging modalities, CodeBind bypasses the need for fully paired data. Unlike traditional hard alignment, CodeBind decomposes features into shared components for semantic consistency and specific components for modality-unique details. This design utilizes a compositional vector quantization scheme, where a shared codebook bridges modality gaps and modality-specific codebooks mitigate representation bias by preventing dominant modalities from overshadowing others. Validated across nine modalities (text, image, video, audio, depth, thermal, tactile, 3D point cloud, EEG), CodeBind achieves state-of-the-art performance in multimodal classification and retrieval tasks.

In recent years, multimodal large language models (MLLMs) have achieved remarkable progress, primarily attributed to effective paradigms for integrating visual and textual information. The dominant connector-based paradigm projects visual features into textual sequence, enabling unified multimodal alignment and reasoning within a generative architecture. However, our experiments reveal two key limitations: (1) Although visual information serves as the core evidential modality in MLLMs, it is treated on par with textual tokens, diminishing the unique contribution of the visual modality; (2) As generation length increases, particularly within a limited context window, the model's dependence on visual information progressively weakens, resulting in deteriorated vision-language alignment and reduced consistency between generated content and visual semantics. To address these challenges, we propose the Vision Inference Former (VIF), a lightweight architectural module that establishes a direct bridge between pure visual representations and the model's output space. Specifically, VIF continuously injects visual semantics throughout the decoding phase of the inference process, ensuring that the model remains firmly grounded in visual content during generation. We conduct experiments on 14 benchmark tasks covering general reasoning, OCR, table understanding, vision-centric evaluation, and hallucination. Experimental results show that VIF consistently improves model performance across diverse architectures while introducing minimal additional overhead. The code for this work is available at https://github.com/Dong-Xinpeng/VIF.

We present a brain-to-image system that decodes visual stimuli from EEG signals recorded during natural image viewing. Our system addresses two tasks: (1) EEG-to-image retrieval, which ranks the correct stimulus image among 200 candidates given an EEG segment, and (2) EEG-to-image reconstruction, which generates an image consistent with the perceived stimulus. For retrieval, we implement a multi-level blurring approach improved with biologically inspired EVNet features and trained with the InfoNCE loss. Evaluated over 10 random seeds for a single subject, the retrieval model achieves a mean final-epoch Top-1 accuracy of 86.30% and Top-5 accuracy of 98.55%. For reconstruction, we implement CognitionCapturerPro, which aligns EEG representations to multi-modal CLIP embeddings, including image, text, depth, and edge embeddings, and synthesizes images with SDXL-Turbo conditioned via IP-Adapter. Averaged over 10 seeds, the reconstruction model achieves a CLIP score of 0.903 using ViT-H-14, a CLIP score of 0.870 using ViT-L/14, and an SSIM of 0.409. These results demonstrate the feasibility of decoding rich visual representations from EEG signals using modern multi-modal alignment and generative modeling techniques.

Multimodal Large Language Models (MLLMs) are vulnerable to jailbreak attacks, which can elicit harmful responses from MLLMs. Many MLLMs support multi-image inputs, inadvertently introducing new vulnerabilities due to less efforts on multi-image safety alignment. Previous MLLM jailbreak methods only uses a single image, which restricts the attack space: they cannot distribute harmful requests across multiple images, carry abundant information, or exploit additional visual reasoning tasks to distract MLLMs. To address these limitations, in this paper, we propose a compositional jailbreak framework, \textbf{DMN}, which leverages \textbf{D}istributed instruction, \textbf{M}ultimodal evidence and a \textbf{N}umber chain task to fully enhance the jailbreak performance. Extensive experiments show that DMN is highly effective for MLLM jailbreaking, e.g. achieving attack success rates of over 90% on GPT-4o, Gemini-2.5-pro and Claude Sonnet 4, surpassing other baselines by a large margin. This compositional, multi-image jailbreak strategy reveals fundamental weaknesses in their safety mechanisms.

Multimodal sentiment analysis relies on textual, acoustic, and visual signals, yet real-world data often suffer from modality missing and quality imbalance. Existing methods generate features for modality missing from available ones, but differences in expression mechanisms and sentiment dynamics across modalities may cause the generated features to deviate from true distributions and mislead prediction. In addition, unreliable modalities may dominate fusion, resulting in representation shift across modality combinations and unstable sentiment representations. To address these challenges, we propose a two-level reference alignment framework. The framework introduces stable references at the feature representation and sentiment decision levels to improve robustness under modality missing. First-level reference alignment leverages complete-modality samples to constrain representations and align different modality combinations into a shared sentiment space. Second-level reference alignment enforces cross-modal consistency at the decision level by suppressing unreliable modalities through prototype retrieval and voting. As a result, the framework maintains stable and reliable sentiment predictions under diverse missing-modality patterns. Experiments on CMU-MOSI and CMU-MOSEI show consistent improvements across various missing-modality settings. Under full-modality input, the proposed method achieves state-of-the-art performance, with ACC of 86.28% and 85.88%, and F1 of 86.24% and 85.86%.

Multimodal pre-training demonstrates strong generalization performance, but this paradigm is often impractical in domains where paired data are scarce. A promising alternative is post-hoc multimodal alignment, which aligns separately pre-trained unimodal encoders using a limited number of paired examples. However, existing methods focus primarily on aligning global representations, missing patch-token relations. This may hinder transfer to tasks that require fine-grained cross-modal matching beyond coarse sample-level semantics. To address this issue, we propose a post-hoc alignment method that learns token-level cross-modal structure using relative representations. Specifically, we represent images and texts through their token-level similarities to a set of learnable anchors in each modality space, which are trained to induce consistent cross-modal similarity patterns for matched pairs. Despite learning only the anchors without heavy projection layers, our approach consistently outperforms existing methods in zero-shot classification, cross-modal retrieval, and zero-shot segmentation by a substantial margin. This highlights the importance of modeling fine-grained cross-modal structure for effective post-hoc multimodal alignment with limited paired data.

Autoregressive next-token training offers a unified formulation for image generation and text understanding, but it also creates strong modality competition that destabilizes optimization and limits large-batch scaling. We show that first-order optimizers such as AdamW are vulnerable to cross-modality gradient heterogeneity, while second-order preconditioning, particularly SOAP, provides a more stable basis for multimodal alignment. Building on this insight, we propose \emph{ML-FOP-SOAP}, a second-order optimization framework with Multi-Level Variance Correction. Our Fisher-Orthogonal Projection suppresses variance-induced modality conflicts, reducing the trade-off between visual generation and textual understanding. To make this practical under large gradient accumulation, we introduce a hierarchical folding strategy that captures fine-grained variance with low micro-step overhead. Experiments on Janus and Emu3 show consistent gains across both modalities and stable training at batch size 8192. Compared with AdamW, our method improves sample efficiency by up to $1.4\times$ and accelerates wall-clock training by up to $1.5\times$, offering a robust optimizer for scaling multimodal foundation models.

Multimodal alignment is commonly learned from isolated image-text pairs via CLIP-style dual encoders, leaving the relational context among entities largely unused. Multimodal attributed graphs (MAGs), where nodes carry multimodal attributes and edges encode corpus structure, provide a natural setting for refining frozen vision-language embeddings. This refinement is challenging: visual, textual, and cross-modal relations often induce different neighborhood geometries, while unrestricted graph propagation can quickly over-smooth retrieval representations. Effectively leveraging graph context therefore requires simultaneously breaking modality-specific topological barriers, controlling the smoothing regime, and preserving informative smoothing before semantic boundaries collapse. We propose Graph-Optimized Multimodal Alignment (GOMA), a structure-driven post-alignment framework that views frozen multimodal embeddings as graph signals and addresses these requirements through a unified retrieval-oriented design. GOMA decouples three key design choices: where messages should flow, how multimodal evidence should propagate, and which smoothing depth should be retained. Concretely, it learns modality-aware propagation operators, performs finite-step coupled smoothing without diagonal cross-modal shortcuts, and adaptively reads out node-specific smoothing trajectories to preserve useful smoothing before collapse. All experiments follow a transductive MAG retrieval protocol where the graph serves only as unlabeled context and diagonal self-pair edges are removed. On seven MAG benchmarks, GOMA achieves state-of-the-art or tied state-of-the-art retrieval and remains substantially more stable than the strongest graph competitor, demonstrating that MAG structure can serve as an effective post-encoder for frozen multimodal embeddings.

Reconstructing precise clinical timelines is essential for modeling patient trajectories and forecasting risk in complex, heterogeneous conditions like sepsis. While unstructured clinical narratives offer semantically rich and contextually complete descriptions of a patient's course, they often lack temporal precision and contain ambiguous event timing. Conversely, structured electronic health record (EHR) data provides precise temporal anchors but misses a substantial portion of clinically meaningful events. We introduce a retrieval-augmented multimodal alignment framework that bridges this gap to improve the temporal precision of absolute clinical timelines extracted from text. Our approach formulates timeline reconstruction as a graph-based multistep process: it first extracts central anchor events from narratives to build an initial temporal scaffold, places non-central events relative to this backbone, and then calibrates the timeline using retrieved structured EHR rows as external temporal evidence. Evaluated using instruction-tuned large language models on the i2m4 benchmark spanning MIMIC-III and MIMIC-IV, our multimodal pipeline consistently improves absolute timestamp accuracy (AULTC) and improves temporal concordance across nearly all evaluated models over unimodal text-only reconstruction, without compromising event match rates. Furthermore, our empirical gap analysis reveals that 34.8% of text-derived events are entirely absent from tabular records, demonstrating that aligning these modalities can produce a more temporally faithful and clinically informative reconstruction of patient trajectories than either source alone.

Despite the recent success of Multimodal Foundation Models (FMs), their reliance on massive paired datasets limits their applicability in low-data and rare-scenario settings where aligned data is scarce and expensive. A key bottleneck is the adoption of an instance-level formulation, which learns alignment by maximizing correlation between individual image-text pairs while neglecting the underlying geometric structure across modalities resulting in a modality gap across input modalities. In this paper, we propose a combinatorial paradigm for multimodal alignment that moves beyond pairwise learning and introduce the \emph{Submodular Modality Aligner (SMA)}, which treats multiple augmentations and descriptions of an entity as a set, leveraging multiple descriptions of the data to capture richer cross-modal structure. We instantiate SMA using a principled objective based on Submodular Mutual Information (SMI), which jointly maximizes inter-modality mutual information while reducing cross-modal divergence. This formulation enables the model to effectively utilize multiple positive associations and extract significantly more information from limited data. We evaluate SMA on 14 zero-shot classification and retrieval tasks from the CLIP benchmark and demonstrate consistent gains in the low-data regime. Notably, SMA achieves strong multimodal generalization using only tens of thousands of samples. This is orders of magnitude fewer than standard approaches. Our results highlight the importance of set-based formulations and submodular objectives for data-efficient multimodal learning.

The design of RNA molecules that interact with specific proteins is a critical challenge in experimental and computational biology. Despite recent progress in natural language modeling and deep learning-based protein design, there remains significant room to improve the frequency of successful interactions and the authenticity of generated sequences for functional applications. In this work, we frame conditional RNA sequence generation as a multi-stage alignment problem, introducing Moirain: a suite of models optimized via multimodal supervised fine-tuning (SFT) and Direct Preference Optimization (DPO). Our approach begins with large-scale pretraining on diverse RNA corpora to capture the fundamental grammars of sequence plausibility. To achieve target-specific generation, we employ a multimodal SFT architecture that conditions RNA synthesis on protein structural and sequential features. Finally, we leverage DPO to refine the model using synthetic interaction data: taking advantage of DPO's unique ability to navigate non-aligned preference spaces, we improve functional fitness without collapsing the learned natural distribution. Extensive evaluation of the Moirain series (Moirain-Base, -Multi, and -DPO) demonstrates that our framework consistently produces novel, diverse, and biologically plausible RNA sequences with superior binding affinities compared to existing baselines.

Emerging multi-modal world models attempt to jointly generate videos across diverse modalities (e.g., RGB, depth, and mask), yet they fail to fully exploit the rich priors of existing foundation models. We propose $M^2$-REPA, the first representation alignment method tailored for multi-modal video generation. Our key insight is that foundation models trained on different modality spaces naturally capture distinct domain-specific priors, acting as complementary "experts." Specifically, we first decouple modality-specific features from the diffusion model's intermediate representations, then align each with its corresponding expert foundation model. To this end, we design two synergistic objectives: a multi-modal representation alignment loss that enforces feature-to-expert matching, and a modality-specific decoupling regularization that encourages complementarity across different modalities. This design enables joint optimization, fully exploiting priors from multiple foundation models. Extensive experiments demonstrate that our method significantly outperforms baselines in visual quality and long-term consistency.

Video moment retrieval is the task of retrieving specific segments of a video corresponding to a given text query. Recent studies have been conducted to improve multimodal alignment performance through visual-linguistic similarity learning at the snippet-level and transformer-based temporal boundary regression. However, existing models do not calculate similarity by considering the relationships between multiple answer segments that match the query. Therefore, existing models are easily influenced by visually similar segments in the surrounding context. Existing models calculate similarity at the snippet-level and ignore the relationships between multiple answer segments corresponding to a single query. Therefore, they struggle to exclude segments irrelevant to the query. To address this issues, we propose ClipTBP, a clip-pair temporal boundary prediction framework based on boundary-aware learning. ClipTBP introduces a clip-level alignment loss for explicitly learning the semantic relationship between answer segments. ClipTBP also predicts accurate temporal boundaries by applying both main boundary loss and auxiliary boundary loss. ClipTBP consistently improves performance when applied to various existing models and demonstrates more robust boundary prediction performance even in ambiguous query scenarios.

Vision-language models have shown strong performance, but they often generalize poorly to specialized domains. While semi-supervised vision-language learning mitigates this limitation by leveraging a small set of labeled image-text pairs together with abundant unlabeled images, existing methods remain fundamentally pairwise and fail to model the global structure of multimodal representation manifolds. Existing topology-based alignment methods rely on persistence diagram matching, which neither guarantees geometric alignment nor utilizes the image-text pairing information central to vision-language learning. We propose Topology-Aware Multimodal Representation Alignment (ToMA), a framework that uses persistent homology to identify topologically salient edges and aligns them across modalities through available cross-modal correspondences. ToMA leverages both H_0-death edges and lightweight H_1-birth edges, allowing it to capture both connectivity and cycle structure without constructing 2-simplices. Experiments show that ToMA yields stable gains, with clear improvements on remote sensing and modest but consistent benefits on fashion retrieval. Additional analysis shows that ToMA is more stable than alternative topology-based objectives and that lightweight H_1-birth edges provide useful higher-order structural signals.

Medical diagnosis requires the effective synthesis of visual manifestations and clinical metadata. However, existing methods often treat metadata as isolated tags, failing to exploit the rich semantic knowledge embedded in clinical descriptions. We propose PRIMA (Pre-training with Risk-integrated Image-Metadata Alignment), a framework that integrates domain-specific knowledge into multi-modal representation learning. We first curate an expert corpus of risk--disease correlations via Retrieval-Augmented Generation (RAG) to refine Clinical ModernBERT, embedding diagnostic priors into the text encoder. To bridge the modality gap, we introduce a dual-encoder pre-training strategy utilizing DINOv3 and our refined Clinical ModernBERT, optimized by a suite of four complementary loss functions. These losses are designed to capture multi-granular semantic alignment and handle the ambiguity of clinical correlations through soft labels. Finally, we leverage Qwen3 to fuse these aligned features for precise disease classification. Extensive experiments demonstrate that PRIMA effectively harmonizes pixel-level features with abstract clinical expertise, consistently outperforming other state-of-the-art methods. Notably, our framework achieves strong performance without requiring massive data collection or exhaustive computational resources. Our code will is available at https://github.com/yqwang01/PRIMA.

Despite remarkable capability in multi-modal understanding, deploying Multi-modal Large Language Models (MLLMs) in open-ended conversational scenarios introduces safety risks that remain poorly addressed by existing alignment methods. Unlike simple malicious visual question and answer (VQA) pairs , multi-turn interactions enable adversaries to incrementally reconstruct harmful intent across dialogues, progressively bypassing safety constraints in ways that are difficult to detect at any individual turn. Meanwhile, conventional reinforcement learning from human feedback (RLHF) approaches are unsuitable for this situation: designed primarily for VQA tasks, they neither capture cross-turn risk dynamics nor scale efficiently without costly manual preference annotation. To close this gap, we introduce \textbf{MINT-Safe}, an open-source visual multi-turn training dataset comprising 11,270 multi-image dialogues and 500 refusal VQA pairs, constructed via multi-agent interaction with text-to-image (T2I) tool-call augmentation. Building on MINT-Safe, we propose \textbf{TAD-Align}, a dialogue safety alignment framework centered on a turn-aware dual-objective reward function. Rather than treating all dialogue turns uniformly, TAD-Align leverages rollout-based safety score variance to dynamically identify turns where the model exhibits inconsistent safety behavior, and adaptively up-weights these turns during optimization. Experiments on Qwen2.5-VL-7B-Instruct and LLaVA-NeXT-7B demonstrate reductions of over 10% in Attack Success Rate (ASR), alongside improvements of at least 8% in harmlessness and 13% in helpfulness on multi-modal multi-turn safety benchmarks, while preserving general model capabilities.

Personalized object detection aims to adapt a general-purpose detector to recognize user-specific instances from only a few examples. Lightweight models often struggle in this setting due to their weak semantic priors, while large vision-language models (VLMs) offer strong object-level understanding but are too computationally demanding for real-time or on-device applications. We introduce MOCHA (Multi-modal Objects-aware Cross-arcHitecture Alignment), a distillation framework that transfers multimodal region-level knowledge from a frozen VLM teacher into a lightweight vision-only detector. MOCHA extracts fused visual and textual teacher's embeddings and uses them to guide student training through a dual-objective loss that enforces accurate local alignment and global relational consistency across regions. This process enables efficient transfer of semantics without the need for teacher modifications or textual input at inference. MOCHA consistently outperforms prior baselines across four personalized detection benchmarks under strict few-shot regimes, yielding a +10.1 average improvement, with minimal inference cost.

Traditional multimodal learning approaches rely on alignment pre-training to bridge vision and language modalities, typically by projecting visual features into discrete text token spaces using large-scale image--text data. We revisit this design choice and propose Inverse-LLaVA, a multimodal architecture that inverts the conventional mapping direction by projecting text embeddings into continuous visual representation space and performing fusion within intermediate transformer layers. This representation-first design enables effective multimodal reasoning without relying on an explicit alignment pretraining stage and significantly reduces dependence on large alignment datasets. Across nine multimodal benchmarks, Inverse-LLaVA demonstrates strong learning efficiency under reduced supervision, achieving substantial gains on reasoning-intensive tasks while exhibiting selective performance drops on perception tasks that depend on explicit visual--text grounding. Our analysis indicates that these trade-offs primarily reflect differences in supervision regime rather than architectural limitations. Together, these results show that alignment pretraining is not strictly required for effective multimodal reasoning and highlight the importance of preserving continuous modality representations, opening a new direction for multimodal architecture design that decouples representation structure from supervision regime for more flexible and efficient multimodal systems.

Latent Diffusion Models have shown remarkable results in text-guided image synthesis in recent years. In the domain of natural (RGB) images, recent works have shown that such models can be adapted to various vision-language downstream tasks with little to no supervision involved. On the contrary, text-to-image Latent Diffusion Models remain relatively underexplored in the field of medical imaging, primarily due to limited data availability (e.g., due to privacy concerns). In this work, focusing on the chest X-ray modality, we first demonstrate that a standard text-conditioned Latent Diffusion Model has not learned to align clinically relevant information in free-text radiology reports with the corresponding areas of the given scan. Then, to alleviate this issue, we propose a fine-tuning framework to improve multi-modal alignment in a pre-trained model such that it can be efficiently repurposed for downstream tasks such as phrase grounding. Our method sets a new state-of-the-art on a standard benchmark dataset (MS-CXR), while also exhibiting robust performance on out-of-distribution data (VinDr-CXR). We further validate our approach through a pilot qualitative study and an experiment on grounded disease classification. Our code will be made publicly available at https://github.com/vios-s.

Different machine learning models can represent the same underlying concept in different ways. This variability is particularly valuable for in-the-wild multimodal retrieval, where the objective is to identify the corresponding representation in one modality given another modality as input. This challenge can be effectively framed as a representation alignment problem. For example, given a sentence encoded by a language model, retrieve the most semantically aligned image based on representations produced by an image encoder, or vice versa. To gain insights into the performance impact of different metrics, embedding spaces, and representation alignment for retrieval tasks, we first empirically investigate the geometric relationships between visual and textual embeddings derived from both vision-language models and combined unimodal models. We then align these representations using four standard similarity metrics as well as two learned ones, implemented via neural networks of different architectures with varying losses across multiple benchmarks. Our experimental findings indicate that cosine similarity consistently outperforms all the investigated metrics in representation alignment tasks, and that Wasserstein distance provides a complementary perspective on cross-modal distributional differences. We also observe that our proposed custom contrastive loss is advantageous over the MSE loss for aligning image and text representations, for both multilayer perceptrons and transformer-based models. Taken together, our findings offer novel insights and practical considerations for researchers working in multimodal information retrieval, particularly in real-world, cross-modal applications. Our code is publicly available.

Although recent large multimodal models (LMMs) show impressive progress on vision language tasks, their alignment with human centered (HC) principles such as fairness, ethics, inclusivity, empathy, and robustness is often overlooked. Existing LMM benchmarks are largely accuracy-agnostic. We present HumaniBench, a unified framework for characterizing HC alignment across realistic, socially grounded visual contexts. It contains 32,000 expert-verified image-question pairs from real-world news imagery, each mapped to one or more HC principles through explicit metrics. Comparing 15 state of the art LMMs reveals consistent trade -offs: proprietary systems lead on ethics, reasoning, and empathy, while open-source models show superior visual grounding and resilience. All models show persistent gaps in fairness and multilingual inclusivity. Chain-of-thought prompting and test-time scaling yield 8to 12 % gains on several HC dimensions. HumaniBench enables fine-grained analysis of alignment trade-offs not captured by conventional multimodal benchmarks. https://vectorinstitute.github.io/humanibench/

Decoding language from the human brain remains a grand challenge for Brain-Computer Interfaces (BCIs). Current approaches typically rely on unimodal brain representations, neglecting the brain's inherently multimodal processing. Inspired by the brain's associative mechanisms, where viewing an image can evoke related sounds and linguistic representations, we propose a unified framework that leverages Multimodal Large Language Models (MLLMs) to align brain signals with a shared semantic space encompassing text, images, and audio. A router module dynamically selects and fuses modality-specific brain features according to the characteristics of each stimulus. Experiments on various fMRI datasets with textual, visual, and auditory stimuli demonstrate state-of-the-art performance, achieving an 8.48% improvement on the most commonly used benchmark. We further extend our framework to EEG and MEG data, demonstrating flexibility and robustness across varying temporal and spatial resolutions. To our knowledge, this is the first unified BCI architecture capable of robustly decoding multimodal brain activity across diverse brain signals and stimulus types, offering a flexible solution for real-world applications.