Longitudinal

Neuroradiologists rarely read a brain MRI in isolation, yet automated brain-MRI report generation has been built almost entirely for single studies. Temporal analysis has been explored on chest radiography and chest CT, but to our knowledge, longitudinal reporting for brain MRI, where interval change is often subtle and spatially distributed, remains unaddressed. We present BrainDiff, the first longitudinal vision-language system for brain MRI. BrainDiff outperforms both frontier general-purpose and single-study neuroimaging models on the same patient pairs. Moreover, BrainDiff retains 91% of internal RadGraph-XL entity+relation F1 (rg_er) on an external, cross-hospital cohort. Beyond the system, we contribute three analyses. First, we identify two independent grounding levers: a counterfactual objective with prior-report dropout, which increases measured image reliance by ~47%, and a staged curriculum. Together, these interventions raise image reliance 2.5-fold from the baseline. Second, we provide a factorial over prior-report availability and image identity, isolating a visual contribution of +0.0387 rg_er, which grows when the prior report is withheld. Third, a cheap change-decodability test for candidate backbones shows that interval change is decodable far more weakly than single-study pathology (0.60 vs. 0.77 AUROC). Code is publicly available at https://github.com/jhuldr/BrainDiff.

Long-tail autonomous driving failures are often framed as rare-object recognition errors. We argue that this view is incomplete: the decision-critical question is not only whether a model recognizes an unusual object, but whether it infers how that object changes the ego vehicle's feasible high-level actions. We formalize this problem as decision-level driving affordance prediction, where a model maps a front-view image, ego-motion history, and navigation command to a structured longitudinal--lateral meta-action. To evaluate this capability, we introduce CoLT-Drive, a 3,536-sample counterfactual long-tail benchmark that inserts rare objects into otherwise fixed driving scenes and measures whether models predict acceptable action pairs. To improve deployable small VLMs, we propose KPA, a knowledge-preserving adaptation framework that combines structured perception-to-decision prompting, SLERP-based expert merging, and RegMoE, a regime-aware LoRA mixture-of-experts module. KPA preserves the pretrained model's open-world knowledge while allocating lightweight adaptation capacity to different driving decision regimes. Experiments on an in-domain driving split and CoLT-Drive show that KPA achieves 60.8% pair accuracy on CoLT-Drive, outperforming the pretrained Qwen3-VL-2B baseline (50.3%) and LoRA SFT (32.4%) while maintaining competitive in-domain accuracy. Our benchmark and code are available at https://huggingface.co/datasets/tangzx2024/CoLT-Drive and https://github.com/tangzhengxu/CoLT-Drive.

Social interaction has become one of the most common uses of LLMs, yet research on emotional bonds with AI has focused largely on how users experience these systems, leaving the systems' role in relationship formation poorly understood. Empirically establishing whether systems actively shape these bonds could blur the boundary between general-purpose AI and companions, affecting governance. In a pre-registered four-week longitudinal study (N = 72, 182,451 lines of conversation), participants conversed with ChatGPT-4o, either under a relational system prompt or unmodified, analyzed through 1) disclosure coding, 2) longitudinal self-reports, 3) topic analysis, and 4) interviews. The central finding is that the system actively shaped the interaction: even unprompted, it produced twice as much self-disclosure as users, steered conversations and initiated intimate exchanges, yet did not deepen users' felt closeness. Relational behavior thus emerged as a default system property, calling for governance based on system behavior, not solely product category.

General-purpose wearable foundation models are pretrained on broad sensor streams and populations, but their representations are not organized around women's health. FemWear is a women's wearable foundation model, obtained by parameter-efficiently repurposing a pretrained general multimodal wearable backbone into a specialized representation for women's health. It keeps the pretrained patch projection and Transformer encoder frozen and trains 239,236 encoder parameters - 1.11% of a 21.54M-parameter encoder - through low-rank residual adapters and causal task-family heads, producing one shared longitudinal representation for menstrual, symptom, affective, sleep/recovery, autonomic, activity, and pregnancy outcomes. We evaluate six cohorts with 63 comparable primary metrics, 33 from women's-health cohorts, while retaining the 32-task OpenMHC ability-retention benchmark. On a fixed participant split over three seeds, FemWear improved cycle-phase macro-F1 by 8.15% and reduced mean absolute error for cramps, mood symptoms, and sleep problems by 9.32%, 5.80%, and 9.43%; 24-hour onset AUPRC decreased by 3.40%. A stricter 42-participant nested leave-one-participant-out audit retained positive changes for 24-hour onset (+2.87%), 72-hour onset (+6.35%), and cramps (+2.19%), while phase, mood, and sleep changes were neutral or negative and no endpoint had a strictly positive corrected confidence interval. Capacity-matched experiments beat a latest-day multilayer perceptron but not shared-GRU or multi-gate mixture-of-experts baselines. Train-only calibration reduced onset expected calibration error by 84.2-88.2% with zero temporal-nesting violations. FemWear is therefore a women's wearable foundation model: a reproducible, parameter-efficient specialization delivering targeted transfer across women's-health tasks and coherent probability outputs.

Personality-conditioned LLM agents (PC-Agents) are increasingly used in emotional support, social simulation, and role-playing, motivating the development of lifelong agents that remain coherent over extended interactions. A key component of such coherence is personality evolution: agents should undergo plausible, psychology-grounded changes as they experience life events in different contexts. Although prior work shows that LLM personalities can shift under contextual perturbations, how these shifts vary across traits, events, personas, and models remains poorly understood. We study event-induced personality change after 11 major life events, using the Big Five traits as a psychometric anchor and interpreting the resulting trajectories against longitudinal evidence from human personality psychology. Across four diagnostic axes, PC-Agents exhibit measurable trait shifts at similar rates for event-trait pairs with and without documented human change directions. Even when shifts follow the expected direction, their magnitudes usually fall below human effect-size ranges. Gender and cultural-region prompts show little moderating effect, while persona-level dispersion is compressed three- to four-fold relative to human samples. To enable systematic comparison, we introduce BFI-Adapt, a reusable benchmark for scoring the directional fidelity of event-induced personality change, and use it to rank 14 models. A validation suite shows that the measured shifts exceed no-event retest noise, remain stable under independently paraphrased prompts, exhibit limited and model-dependent convergence with scenario-based behavioral choices, and persist across intervening unrelated dialogue. Together, these checks establish the measured trajectories as robust event-conditioned response patterns. Our results suggest that current PC-Agents simulate the mean of human personality dynamics, but not its shape.

Most agent benchmarks evaluate tasks independently and cannot measure whether experience from one task helps with later tasks. Existing self-evolution benchmarks do not jointly cover professional workflows, open-ended deliverables, and multi-aspect evaluation. We introduce FinEvo-Bench, a longitudinal benchmark with 120 real-case-grounded tasks, 20 business scenes across six financial domains. Institution-provided professional procedures define the required operations and constraints. Eligible institution-provided and publicly documented cases supply the task facts. Each scene contains six related but substantively distinct cases that share a professional procedure and a manually reviewed rubric for task quality and financial compliance. We compare four self-evolving agent scaffolds using the same Qwen3.7-Max backbone and three independently shuffled, globally interleaved task streams. Paired non-evolving controls estimate each scaffold's self-evolution gain from retained experience, while an independent Claude Code scoring agent backed by Claude Opus 4.6 evaluates all outputs. Letta achieves the highest evolved score (91.65) and fewest compliance issues (0.09 per task); Codex achieves the largest self-evolution gain (+19.37). Across scaffolds, the evolving condition raises scores by 9.33-19.37 points and reduces compliance issues by 0.12-0.44 per task. Paired score gains at within-scene ranks 4-6 exceed those at ranks 1-3 by 6.10-8.70 points. In Claude Code, skill-only evolution produces higher task quality and fewer compliance issues than memory-only and combined memory-skill evolution. Across all four scaffolds, rubric feedback also yields higher scores and fewer compliance issues than reference-answer feedback. FinEvo-Bench measures both professional performance and self-evolution ability: how effectively an agent turns prior experience into later improvement.

Computed tomography (CT) is widely used for clinical diagnosis and longitudinal follow-up, yet automatically generating accurate and complete radiology reports from three-dimensional (3D) CT remains challenging. Existing methods improve fine-grained correspondence between images and text by modeling anatomical regions, but remain centered on the current examination. Consequently, patient-specific longitudinal changes within individual regions remain insufficiently modeled. Meanwhile, interval changes are often distributed across multiple anatomical regions, complicating a coherent assessment of the overall longitudinal state. We propose Anatomically Localized Temporal Evidence Representation (ALTER) to address these limitations. Global Prior Integration (GPI) incorporates the prior CT and report to establish historical context for the current examination. Regional Proxy Differencing (RPD) enables each current anatomical region to retrieve a historical proxy from a single shared encoding of the prior volume and to derive localized interval evidence. Interval Change Fusion (ICF) further combines current abnormality states with region-distributed differences, converting their joint representation into change-aware soft prompts that guide report generation. ALTER achieves state-of-the-art results on most evaluation metrics across the RadGenome-ChestCT validation and CTRG-Chest-548K test sets. Code and data preprocessing details are available at https://github.com/peytonkarlie/ALTER/tree/main.

Continuum robots often operate in uncertain environments, where accurate state estimation is essential for safe interactions. Estimate uncertainty is inherently spatially non-uniform: confidence varies depending on where measurements are available. Global estimation accuracy is not always the top priority, but rather achieving sufficient confidence at task-relevant locations along the robot. This extended abstract introduces mechanically reconfigurable sensing enabling uncertainty-shaping in state estimation for continuum robots. We present a concept hardware design demonstrating the feasibility of longitudinal translation of a sensor within a continuum robot. We demonstrate that state estimation confidence can be reconfigured by varying the sensor location, and show a reduction of full-body shape estimation errors when sliding the sensor back and forth over time, compared to a single fixed tip sensor.

Memory is essential as language agents move from isolated tasks to long-horizon, stateful workflows, yet existing evaluations often reduce it to retrieval or question answering. We introduce ContextWeave, a longitudinal benchmark that evaluates whether recalled experience improves downstream agent performance in realistic office-work streams. ContextWeave reconstructs privacy-preserved, multi-month workflows of 14 participants into 1,005 executable tasks, including 568 core evaluation tasks, with instructions, containerized environments, trajectories, and task-specific rubrics. It measures workspace quality and alignment with participant-specific preferences, complemented by diagnostics of relevance, continuity, solvability, and robustness to misleading recall. Across six memory components under a fixed model, the strongest configuration raises Workspace Score from 68.08 to 78.20 and Preference Score from 41.50 to 70.60. With a fixed memory component, recall improves both outcomes for all five tested base models, although gains vary substantially. Our analysis shows that actionable, experience-rich memory supports workflow continuation and reduces redundant exploration more effectively than compact summaries, while it can also be more susceptible to misleading recall. These findings motivate memory systems that optimize not only retrieval relevance but also reliable use during execution.

Language models have taken on the role of a very new type of technology, by virtue of their "human-ness" and rapid integration into users' daily lives. This combination of features can introduce longitudinal risks---cognitive, developmental and socio-affective changes in humans---that might not surface during a short-term interaction, but can have lasting long-term effects on users. This forms the basis of a critical new mission for NLP: to pivot from static, short-term evaluations of text generations to long-term measurements of behavioral changes, towards a diachronic understanding of human-model interactions. In this work, we draw from measurements used in social science fields that are crucial to understand emergent phenomena in longitudinal data. We discuss how computational methods in the field of NLP need to be combined with such measurements, not only to understand long-term safety risks of human-model interactions, but to help steer model development towards positive rather than negative outcomes for users. This ability to model human behavioral shifts as a function of model interactions can facilitate online rather than post-hoc detection of problematic behaviors, and should be leveraged in alignment frameworks to mitigate long-term risks in users.

Line-haul trucking costs are dominated by three comparably sized components: energy, driver labor, and equipment. Most efficiency technologies address only one component at a time. This paper presents Robostreet Flow, a freight architecture that jointly optimizes the vehicle, convoy formation, and operating model to minimize cost per ton-mile on high-volume point-to-point corridors. The Flow platform is a battery-electric 6x4 tractor with a teardrop single-seat cab and a drag coefficient of 0.35, approximately 40% below that of conventional Class 8 tractors. A carbon-composite monocoque and structurally integrated batteries reduce net vehicle weight by 50%. A 513 kWh tractor battery and a 340 kWh powered trailer battery provide a 500-mile single-charge range. Four Flow trucks operate as a coordinated convoy with a safety driver only in the lead vehicle, while three followers operate in SAE Level 4 automated mode. Computational fluid dynamics simulations show that close following at an 8 m gap reduces follower drag coefficients by 42-48% and follower peak frontal pressure by approximately a factor of four relative to the exposed lead vehicle. A longitudinal energy model calibrated to these results predicts fleet-average consumption of 1.27 kWh/mi in convoy, compared with 1.60 kWh/mi for an isolated vehicle, for a 20.5% energy saving. Electricity cost is approximately 17% of the equivalent diesel fuel cost. Amortizing one driver across four trucks and accounting for the additional payload enabled by lightweighting reduce operating cost from 9.4 to 4.1 cents per ton-mile, a 56% reduction relative to a diesel baseline. Sensitivity analysis, a hub-to-hub operating concept, and regulatory implications are also presented.

Longitudinal T cell receptor repertoires contain signals of clonal expansion, contraction, disappearance, and reappearance after immune perturbation. Static repertoire language models usually summarize a sample as a bag of sequences, so the sampling interval, sequencing depth, and clone presence pattern are only weakly represented. This paper presents DynImmune-BERT, a continuous time repertoire model for patient level immune status prediction. The method combines depth adaptive centered log ratio initialization, clone presence gated Neural ordinary differential equation dynamics, bounded neighborhood self attention, event based state restart, and a hybrid transport objective that supervises dominant and rare clone mass. A low rank meta adapter initializes reappearing clonotypes while keeping the parameter count independent of the number of observed clones. The evaluation separates literature reported baselines from internally controlled temporal comparisons, reports uncertainty for small external cohorts, adds calibration and threshold diagnostics, and visualizes latent clone trajectories and attention neighborhoods. The results indicate that event aware temporal modeling can complement strong static encoders when longitudinal repertoire structure is available, while small external cohorts and protocol differences require cautious interpretation.

Longitudinal tumor measurements, dropout information, and genetic covariates provide complementary information about treatment response, but integrating these data sources within a single population modeling framework remains challenging. We extend the empirical Bayes variational autoencoder (EB-VAE) framework to joint longitudinal and time-to-event modeling and evaluate it on tumor growth data. The framework represents inter-individual variability using latent individual effects regularized by a covariate-conditioned empirical Bayes prior, while a decoder maps these latent effects to tumor-volume trajectories. To account for informative dropout, the decoder was augmented with a hazard model, yielding joint predictions of tumor growth and time to dropout. We further compared fully neural and hybrid semi-mechanistic decoder formulations and incorporated genomic covariates through a genetics-conditioned prior adaptation. The hybrid decoder recovered treatment-effect parameters broadly consistent with previously reported nonlinear mixed-effects estimates, while achieving prior predictive performance comparable to the neural decoder. The joint model reproduced both tumor-volume distributions and dropout patterns in held-out individuals, and genetic conditioning improved individual-level prior predictions in both cutaneous melanoma and breast cancer experiments. Stability selection identified several biologically plausible genetic indicators, including alterations in BRAF, NRAS, NF1, and MDM2. These results demonstrate that EB-VAE provides a flexible probabilistic framework for combining neural dynamics, mechanistic structure, time-to-event modeling, and high-dimensional covariates in pharmacometric applications.

Generative models have changed how machine learning represents complex data distributions, especially in language and vision, yet many real-world systems are observed instead as continuous, high-dimensional, and noisy sensor time series. Existing generative modeling of sensor data, however, remains fragmented across modalities, datasets, and task formulations, limiting a systematic understanding of when, how, and why generative models succeed or fail in real-world settings. To address this gap, we introduce SensorGen, a large-scale study of sensor-signal generation spanning 14 settings across 4 domains, 7 datasets, and 12 signal modalities. Leveraging SensorGen, we systematically evaluate generative models from five major families and uncover three key findings: (1) flow-matching models provide strong overall performance across most settings; (2) signal properties matter, with demographic covariates improving longitudinal generation and time-frequency modeling improving high-frequency signal generation; and (3) generated signals have practical utility beyond visual realism, with scaling improving generation quality and synthetic data improving downstream performance. Together, SensorGen establishes a broader understanding of design choices, evaluation protocols, and failure modes in real-world sensor data generation.

As autonomous vehicles (AVs) operate in increasingly dynamic traffic conditions, lateral control must be performed while longitudinal speed and acceleration vary. Yet many existing lateral controllers rely on constant-speed or operating-point-based assumptions, which can degrade performance during transient longitudinal maneuvers. Moreover, most methods assume precisely known vehicle parameters, despite real-world parametric uncertainties. To address these limitations, this paper presents a longitudinal-motion-aware robust nonlinear lateral control framework for AVs. It first derives a tracking error model that depends on varying longitudinal speed and acceleration. Using this model, feedback linearization is employed to obtain a linear input-output relation for lateral error tracking while embedding longitudinal motion into the control law. The resulting internal dynamics are then analyzed to ensure overall system stability. To address parameter uncertainty, two robust control designs with distinct implementation trade-offs are proposed: (i) a Lyapunov redesign (LR) approach inspired by sliding mode control, and (ii) an incremental nonlinear dynamic inversion (INDI) method. Both are rigorously analyzed and proven to ensure ultimate boundedness, with key robustness-tuning parameters explicitly identified. Simulations demonstrate enhanced tracking accuracy, consistent performance across varying speeds and accelerations, and robustness to model uncertainties, while also examining the effects of the robustness-related parameters. Real-vehicle tests further confirm real-time implementation and practical path-tracking performance on actual hardware.

Model cards quote trust-benchmark scores without recording when they were measured, and the same number is routinely carried across successive checkpoints of one release line as if the model behind it had not shifted. We test whether it has shifted by auditing four open-source release lines, Yi, Qwen, Mistral, and Gemma, at three successive generations each, on a fixed basket of trust benchmarks under multiple prompt templates. Mean absolute adjacent-generation drift lands well above an independence-based no-drift reference null, and the gap persists when we drop a benchmark, drop a release line, or switch to strict scoring. We therefore conclude that a trust score attached to a release line should not be carried forward to the next checkpoint without remeasurement; it should instead be reported as a checkpoint-bound, dated artefact, which we package as a longitudinal model card. Closed APIs, larger models, canonical benchmark protocols, and fixed month-cadence rules lie outside the audited scope and require their own evaluation.

Longitudinal modelling of Alzheimer's disease progression is clinically useful only if it can describe not just the most likely next diagnosis, but how a patient may evolve over time and how reliable that forecast is. Most deep learning approaches reduce this problem to single-step classification, treating cognitively normal, mild cognitive impairment, and dementia as flat categories while providing limited insight into how uncertainty accumulates across future visits. We propose a probabilistic framework that combines ordinal diagnosis prediction, multi-horizon trajectory generation, and decomposed uncertainty estimation. A Temporal Fusion Transformer encoder is adapted with a CORAL ordinal output layer, asymmetric loss weighting, and converter oversampling to respect disease-stage ordering and improve sensitivity to MCI-to-dementia transitions. Conditioned on the learned patient-context representation, an autoregressive Mixture Density Network generates five-year probabilistic trajectories for diagnosis state, CDR Sum of Boxes, MMSE orientation, and hippocampal volume. On ADNI, the model outperforms linear, recurrent, and transformer baselines for next-visit diagnosis prediction, with the strongest gains on MCI-versus-dementia discrimination. Generated trajectories achieve near-nominal 90% credible interval coverage, widening uncertainty across the forecast horizon, and biomarker dynamics consistent with expected Alzheimer's disease progression. We further separate aleatoric from epistemic uncertainty using analytic mixture variance and a five-member bootstrap ensemble, which provides the strongest encoder diversity and output-level epistemic signal. Epistemic uncertainty is higher for rare progression archetypes, MCI and dementia patients, and under external evaluation on OASIS-3, where it increases alongside prediction error.

Undergraduate computer science is governed by international curricular guidelines revised about once a decade, yet programs lack a reliable, reproducible way to measure how completely they cover the current guidelines and how that coverage shifts when the guidelines are restructured. We address this with a human-in-the-loop pipeline that measures a program's coverage of an external body of knowledge, applied longitudinally to one accredited BSc in Computer Science against Computer Science Curricula 2013 (CS2013) and 2023 (CS2023). The pipeline represents the program and each guideline as structured corpora, generates candidate course-to-knowledge-unit matches by semantic retrieval, and confirms them through human judgment under an explicit coverage definition. Of seven benchmarked retrievers, a reciprocal-rank-fusion ensemble was strongest, and a reputed long-context model underperformed a small sentence model, so retriever choice must be measured. Both maps were validated by an independent second rater (Cohen's kappa 0.64 for CS2023, 0.69 for CS2013). The program covers 49.7% of CS2023 and 50.9% of CS2013 knowledge units, near-constant across a decade. Extending the same retrieve-then-confirm design to competency articulation and cognitive depth shows that the program articulates the competency for ~88% of covered units under each guideline, yet delivers it at the recommended depth for 76% of present units under CS2023 against 95% under CS2013, a gap reflecting the newer guideline's raised expectations, not the program. The longitudinal comparison separates persistent structural gaps (parallel and distributed computing, foundations of programming languages, systems fundamentals), uncovered against both guidelines and ABET, from differences that reflect the standard's evolution. The instrument is reusable and available from the authors on request.

Modeling dimensional affect in longitudinal text requires distinguishing current affect estimation from future affective change forecasting. Existing approaches often treat each text as an independent observation and apply similar assumptions to both tasks, without testing whether they rely on different information sources. This paper investigates that distinction using longitudinal self-reported ecological essays and feeling-word entries. We propose the Trait--State Affective Prediction (TSAP) framework and its temporal extension E-TSAP for per-text valence and arousal prediction, evaluated on a held-out prediction test set of 1,737 entries from 91 users. We further propose the Affective Change Forecaster Hybrid (ACF-Hybrid) for next-step affective change forecasting, evaluated on a held-out forecasting test set of 46 users. For prediction, E-TSAP achieves composite Pearson correlations of 0.670 for valence and 0.449 for arousal. For forecasting, textual representations perform worse than compact numeric trajectory baselines: the text-inclusive model achieves only r=0.316 for valence and r=0.284 for arousal, whereas a simple prior-state baseline reaches r=0.615 and r=0.670, respectively. ACF-Hybrid, using dimension-specific numeric trajectory features, achieves r=0.659 for valence and $r=0.658$ for arousal. These results show that textual semantics support current affect prediction, whereas future affective change is better captured through prior numeric trajectory dynamics.

Accurate estimation of long-term care transition probabilities is central to disability insurance pricing, reserving, and solvency assessment. Classical actuarial multi-state models commonly rely on Markov, semi-Markov, or proportional-hazard specifications, which provide a direct connection to cohort projection but may be restrictive for irregular longitudinal health data with nonlinear aging patterns and heterogeneous covariate histories. This paper develops a well-calibrated estimator of multi-state transition probabilities for irregular longitudinal health data. The model learns from individual health history, incorporates the time elapsed between observations, and conditions transition probabilities on demographic and socioeconomic attributes. It produces a valid probability distribution over the next observed health state, with four possible states: healthy, mild disability, severe disability, and death. Individual probabilities are aggregated by age group and origin state to form transition matrices compatible with actuarial cohort projection. Using longitudinal data from the Health and Retirement Study, we compare the proposed estimator with logistic regression, gradient-boosted trees, a recurrent neural network, and a last-state persistence benchmark. The evaluation considers probabilistic accuracy, endpoint discrimination and calibration for severe disability and death, risk concentration, and transition matrix error after aggregation. The proposed estimator improves severe disability discrimination relative to logistic regression and gradient-boosted tree benchmarks, maintains strong calibration, and yields the lowest transition matrix error among the evaluated models in the held-out test analysis. Results show that a structured machine learning estimator can support long-term care transition modeling when judged by calibration and projection fidelity, beyond discrimination.

MRI provides excellent soft-tissue contrast without ionizing radiation, but long acquisition times increase patient discomfort while also raising exam costs and limiting scanner throughput. A common approach to reduce scan time is to acquire fewer measurements, which yields an ill-posed linear inverse problem; recovering diagnostic-quality images therefore requires incorporating prior knowledge beyond the measured data. In follow-up exams, the most recent prior scan of a patient can provide a highly informative subject-specific context, but practical use is complicated by temporal changes (including pathology progression), misalignment between scans, and protocol drift across acquisitions. In this work, we introduce L-TGVN, a Longitudinal Trust-Guided Variational Network that leverages prior scans as side information to reconstruct the current scan from heavily undersampled measurements. Crucially, L-TGVN constrains the influence of prior scans to be consistent with the acquired measurements. Unlike many existing longitudinal reconstruction methods, it does not require explicit pre-registration between prior and current scans. It further accommodates differences in acquisition protocols across visits (e.g., changes in sequence parameters). We evaluate L-TGVN against matched-capacity baselines, including prior-guided methods and methods that do not use longitudinal priors, and observe consistent improvements in standard quantitative metrics together with better preservation of fine structures at challenging accelerations. Source code is available at github.com/sodicksonlab/L-TGVN.

Quantifying impact phenomena in badminton smashes is important for evaluating both athletic performance and equipment; however, conventional measurement systems involve trade-offs between temporal resolution, data efficiency, and preparation effort. This study proposes a measurement method using two synchronized event cameras to automatically estimate impact time, impact location on the racket face, and post-impact shuttlecock speed in an integrated manner within the same trial. The swing interval was detected from event rate statistics, impact time was estimated from the shuttlecock trajectory inflection in the lateral-view event data, impact location was determined by ellipse fitting to the racket face in the rear-view event image, and shuttlecock speed was calculated in the sagittal plane. To validate the proposed method, Bland-Altman analysis was performed against a high-speed camera-based reference method using 125 smash trials from five players. Impact time and shuttlecock speed were estimated in all 124 analyzable trials, and impact location was estimated in 93.5% (116/124). The bias (95% CI) for impact time, medio-lateral impact location, longitudinal impact location, and shuttlecock speed were 1.84 ms (1.45 to 2.23), 3.45 mm (2.18 to 4.72), -1.92 mm (-2.97 to -0.88), and -1.00 m/s (-2.46 to 0.46), respectively. No proportional bias was observed for any metric. These results suggest that the proposed method can serve as a useful tool for integrated assessment of badminton smash performance and equipment in practical settings.

Tracking tumor lesions across serial CT scans is essential for oncological response assessment. Existing automated methods face a fundamental trade-off: end-to-end trackers achieve high automation but offer no opportunity to correct silent tracking failures, while decoupled registration-segmentation pipelines permit user verification yet discard the lesion's prior appearance, limiting accuracy in ambiguous cases. In this work, we propose a Verified Tracking paradigm: a clinician verifies a registration-proposed prompt, which the model leverages alongside the baseline lesion appearance to resolve segmentation ambiguities. We present a unified framework combining early spatial prompt fusion with latent temporal difference weighting for longitudinally-informed segmentation. To address data scarcity, we leverage large-scale synthetic pretraining, proving essential for exploiting longitudinal context, improving performance by up to 4.5 Dice points over training from scratch. Our approach secured first place in the MICCAI autoPET IV challenge. We further curate and release PanTrack, a new longitudinal pancreatic cancer benchmark, to assess out-of-distribution generalization. Experiments show that our model outperforms prior work in both fully automatic and the proposed verified tracking setting offering a clinically safe middle ground between automation and control. Code, model and dataset will be released at https://github.com/MIC-DKFZ/LongiSeg

We introduce a novel Longitudinal Focused Attention Meditation Electroencephalography (L-FAME) dataset and an accompanying benchmark, designed to foster research into the neural effects of various meditation practices and the evolution of these effects over a six-week training period. The dataset contains EEG recordings and psychological assessments from 74 healthy college participants, collected at two distinct time points: pre-intervention and post-intervention. Participants were randomly assigned to one of three distinct meditation groups: two mantra-based techniques (SA-TA-NA-MA and Hare Krishna) and one Breath Focus practice. Leveraging this unique longitudinal and comparative dataset, we propose a benchmark suite comprising three distinct classification tasks: (1) cognitive state decoding to distinguish between resting and meditation states, (2) fine-grained classification of the specific meditation techniques, and (3) cross-session adaptation to evaluate model generalization across the longitudinal time gap. We provide comprehensive baseline results for these tasks utilizing a range of classical machine learning algorithms and deep learning architectures. The complete dataset, preprocessing pipelines, and benchmark evaluation code will be publicly released, offering a valuable resource and a standardized framework for the development and comparison of new analytical methods in computational meditation research and EEG-based machine learning. The dataset is available at https://huggingface.co/datasets/L-FAME-Dataset-Benchmark/L-FAME

Rubric-based reward shaping provides interpretable and editable reward signals for fine-tuning LLMs via reinforcement learning (RL), but existing adaptive rubric methods typically update criteria from local evidence such as the current batch or instance-level comparisons. This local view discards diagnostic information produced during training, making it difficult to track recurring failures, evaluate previous rubric edits, or raise standards once earlier criteria become saturated. We introduce AMARIS, A Memory-Augmented Rubric Improvement System that grounds rubric updates in longitudinal training evidence. AMARIS stores rollout analyses, step-level summaries, and rubric update records in a persistent evaluation memory, then retrieves recent and semantically relevant history to revise rubrics. We evaluate AMARIS across science, medicine, instruction following, and creative writing under both global and instance-specific rubric settings. AMARIS improves over static, local-adaptive, and memory-ablated baselines, such as +2.8 points on GPQA-Diamond and +2.2 points on IFBench over the strongest baselines, while analysis shows that memory reduces oscillatory rubric edits and supports a progression from early failure correction to later curriculum advancement. AMARIS runs asynchronously alongside the normal RL loop, reducing blocking latency relative to synchronous rubric updates.

Longitudinal chest X-ray (CXR) interpretation requires reasoning over disease evolution across multiple patient visits, yet most existing medical VQA benchmarks focus on single images or short-horizon image pairs. We introduce MI-CXR, a benchmark for standardized evaluation of Multi-Interval longitudinal reasoning over multi-visit CXR sequences, without requiring free-form report generation or additional clinical context. MI-CXR comprises five-way multiple-choice questions over five-visit patient timelines and instantiates three complementary task families: Temporal Event Localization, Interval-wise Change Reasoning, and Global Trajectory Summarization, which assess clinically grounded visual reasoning over time. Evaluating 14 state-of-the-art vision-language models (VLMs) shows low overall performance, with an average accuracy of 29.3%, only modestly above random guessing. Using stage-wise diagnostic probing, we find that models often produce locally plausible interval descriptions but fail to enforce temporal constraints or compose evidence into globally consistent decisions over the full timeline. These findings reveal key limitations of current VLMs and establish MI-CXR as a principled benchmark for longitudinal medical reasoning. The benchmark is available at https://github.com/AIDASLab/MI-CXR

Comparative evaluation of multiple dynamic treatment policies is essential for healthcare and policy decisions, yet conventional longitudinal causal inference methods estimate each in isolation, preventing information sharing across counterfactuals. We demonstrate that this separate estimation paradigm induces a structurally uncontrolled second-order bias, inflating finite-sample variance even after standard debiasing with longitudinal targeted maximum likelihood estimation(LTMLE). To address this, we propose a policy-aware reparameterization of Iterative Conditional Expectation (ICE) Q-functions that enables joint estimation through shared representations. We implement this approach in the Policy-Encoded Q Network (PEQ-Net), an architecture centered on a shared policy encoder. The encoder is trained using kernel mean embeddings, ensuring that the learned representation space reflects population-level policy dissimilarities. After applying an LTMLE correction step, we prove this design imposes a structural constraint on the second-order remainder, thereby stabilizing finite-sample variance. Experiments on semi-synthetic datasets demonstrate that PEQ-Net consistently outperforms existing ICE-based methods, achieving substantial reductions in root-mean-square error, particularly when evaluating closely related policies.

Longitudinal clinical notes contain rich evidence of how patients evolve over time, but converting this signal into training supervision for clinical prediction remains challenging. We extend Foresight Learning to clinical prediction by converting time-ordered MIMIC-III notes into examples consisting of past patient context, a natural-language question about a possible future event, and a label resolved from later documentation. This process yields 6,900 prediction examples from 702 admissions across medications, procedures, organ support, microbiology, and mortality. A small LoRA adapter trained on these examples improves over the prompted base model, reducing expected calibration error from 0.1269 to 0.0398 and Brier score from 0.199 to 0.145, while slightly outperforming GPT-5 point estimates on held-out questions. The approach enables reusable clinical prediction supervision from longitudinal notes without hand-engineered structured features or endpoint-specific classifiers.

Chest radiograph interpretation requires temporal reasoning over prior and current studies, yet most vision-language models are trained on static image-report pairs and lack explicit supervision for modeling longitudinal change. We introduce CheXTemporal, a dataset for temporally grounded reasoning in chest radiography consisting of paired prior-current chest X-rays (CXR) with finding-level temporal and spatial annotations. The dataset includes a five-class progression taxonomy (new, worse, stable, improved, resolved), localized spatial supervision of pathology, explicit spatial-temporal alignment across paired studies, and multi-source coverage for cross-domain evaluation. We additionally construct a 280K-pair silver dataset with automatically derived temporal and anatomical supervision for large-scale evaluation under weaker supervision. Using these resources, we evaluate multiple state-of-the-art vision-language CXR models on grounding and progression-classification tasks in a zero-shot setting. Across both gold and silver evaluations, current models exhibit consistent limitations in spatial grounding, fine-grained temporal reasoning, and robustness under distribution shift. In particular, models perform substantially better on salient progression categories such as worse than on temporally subtle states such as stable and resolved, suggesting limited modeling of longitudinal disease evolution in chest radiography.

Millions of people now turn to artificial intelligence (AI) systems for personal advice, guidance, and support. Such systems can be sycophantic, frequently affirming users' views and beliefs. Across five preregistered studies (N = 3,075 participants, 12,766 human-AI conversations), including a three-week study with a census-representative U.S. sample, we provide longitudinal experimental evidence that sycophantic AI shifts how users approach their closest relationships. We show that sycophantic AI immediately delivers the emotional and esteem support users typically associate with close friends and family. Over three weeks of such interactions, users became nearly as likely to seek personal advice from sycophantic AI as from close friends and family, and reported lower satisfaction with their real-world social interactions. When given a choice among AI response styles, a majority preferred sycophantic AI -- not for the quality of its advice, but because it made them feel most understood. Together, these findings offer a relational account of AI sycophancy and its impacts.

Individualized Alzheimer's disease (AD) progression prediction requires models that use irregular visits, account for censoring, avoid diagnostic leakage, and provide calibrated horizon risks. We propose PROgression-aware MultI-horizon Survival Estimation for Alzheimer's Disease (PROMISE-AD), a leakage-safe survival framework for predicting conversion from cognitively normal (CN) to mild cognitive impairment (MCI) and from MCI to AD dementia using ADNI/TADPOLE tabular histories. PROMISE-AD converts pre-index visits into tokens with standardized measurements, missingness masks, longitudinal changes, time-normalized slopes, visit timing, and non-diagnostic categorical attributes. A temporal Transformer fuses global, attention-pooled, and latest-visit representations to estimate a progression score and latent discrete-time mixture hazards. Training combines survival likelihood, horizon-specific focal risk loss, progression ranking, hazard smoothness, and mixture-balance regularization, followed by validation-set isotonic calibration for 1-, 2-, 3-, and 5-year risks. In held-out testing across three seeds, PROMISE-AD achieved an integrated Brier score (IBS) of 0.085 $\pm$ 0.012, C-index of 0.808 $\pm$ 0.015, and mean time-dependent AUC of 0.840 $\pm$ 0.081 for CN-to-MCI conversion, yielding the lowest IBS among compared methods. For MCI-to-AD conversion, PROMISE-AD achieved the highest C-index (0.894 $\pm$ 0.018) and near-ceiling 5-year discrimination (AUROC 0.997 $\pm$ 0.003; AUPRC 0.999 $\pm$ 0.001), although some baselines had lower IBS. Ablations and interpretability supported longitudinal change features, fused temporal representations, mixture hazards, cognitive and functional measures, APOE4 status, and recent conversion-proximal visits. These findings suggest that progression-aware survival modeling can provide interpretable multi-horizon AD conversion risk estimates.

Qualitative methods are important to use alongside quantitative methods to improve Human-Robot Interaction (HRI), yet they are often applied in static or one-off formats that cannot capture how stakeholder perspectives evolve over time. This limitation is especially evident in clinical contexts, where families and patients face heavy burdens and cannot easily participate in repeated research encounters. To address this gap, we introduce continuous focus groups, a longitudinal and co-agential method designed to sustain dialogue with assistive care professionals working with children with autism spectrum disorder (ASD). Three focus groups were organized across successive phases of a robot-assisted therapeutic protocol, enabling participants to revisit and refine earlier views as the intervention progressed. Results show that continuity fostered trust, supported the integration of tacit clinical expertise into design decisions, and functioned as an ethical safeguard by allowing participants to renegotiate involvement and surface new concerns. By bridging the therapeutic iteration of families, children, and clinicians with the research-design iteration of researchers and developers, continuous focus groups provide a methodological contribution that is both feasible in practice and rigorous in design. Beyond autism care, this approach offers a transferable framework for advancing qualitative research in HRI, particularly in sensitive domains where direct user participation is limited and continuity is essential.

Longitudinal information in radiology reports refers to the sequential tracking of findings across multiple examinations over time, which is crucial for monitoring disease progression and guiding clinical decisions. Many recent automated radiology report generation methods are designed to capture longitudinal information; however, validating their performance is challenging. There is no proper tool to consistently label temporal changes in both ground-truth and model-generated texts for meaningful comparisons. Large language models (LLMs) offer a promising annotation alternative, as they are capable of capturing nuanced linguistic patterns and semantic similarities without extensive manual intervention. They also adapt well to new contexts. In this study, we therefore propose an LLM-based pipeline to automatically annotate longitudinal information in radiology reports. The pipeline first identifies sentences containing relevant information and then extracts the progression of diseases. We evaluate and compare five mainstream LLMs on these two tasks using 500 manually annotated reports. Considering both efficiency and performance, Qwen2.5-32B was subsequently selected and used to annotate another 95,169 reports from the public MIMIC-CXR dataset. Our Qwen2.5-32B-annotated dataset provided us with a standardized benchmark for evaluating report generation models. Using this new benchmark, we assessed seven state-of-the-art report generation models. Our LLM-based annotation method outperforms existing annotation solutions, achieving 11.3% and 5.3% higher F1-scores for longitudinal information detection and disease tracking, respectively. The source code is available at https://github.com/wxinyi1996/Standardizing-Longitudinal-Chest-X-ray-Report-Evaluation-via-Large-Language-Model-Annotation.git.

While NLP typically treats documents as independent and unordered samples, in longitudinal studies, this assumption rarely holds: documents are nested within authors and ordered in time, forming person-indexed, time-ordered $\textit{behavioral sequences}$. Here, we demonstrate the need for and propose a longitudinal modeling and evaluation paradigm that consequently updates four parts of the NLP pipeline: (1) evaluation splits aligned to generalization over people ($\textit{cross-sectional}$) and/or time ($\textit{prospective}$); (2) accuracy metrics separating between-person differences from within-person dynamics; (3) sequence inputs to incorporate history by default; and (4) model internals that support different $\textit{coarseness}$ of latent state over histories (pooled summaries, explicit dynamics, or interaction-based models). We demonstrate the issues ensued by traditional pipeline and our proposed improvements on a dataset of 17k daily diary transcripts paired with PTSD symptom severity from 238 participants, finding that traditional document-level evaluation can yield substantially different and sometimes reversed conclusions compared to our ecologically valid modeling and evaluation. We tie our results to a broader discussion motivating a shift from word-sequence evaluation toward $\textit{behavior-sequence}$ paradigms for NLP.

This work presents an algorithm for changing from latitudinal to longitudinal formation of autonomous aircraft squadrons. The maneuvers are defined dynamically by using a predefined set of 3D basic maneuvers. This formation change is necessary when the squadron has to perform tasks which demand both formations, such as lift off, georeferencing, obstacle avoidance and landing. Simulations show that the formation change is done without collision. The time complexity analysis of the transformation algorithm reveals that its efficiency is optimal, and the proof of correctness ensures its longitudinal formation features.