Medical Image Benchmarks

Follow this topic Ask about this topic

Momentum

20 papers in the last four weeks, up 25% on the four weeks before. 0.2% of all new papers.

Jul 13Week of Sep 28

Latest papers 237

May 7, 2026cs.CV

RAM-H1200: A Unified Evaluation and Dataset on Hand Radiographs for Rheumatoid Arthritis

Rheumatoid arthritis (RA) assessment from hand radiographs requires multi-level analysis and modeling of anatomical structures and fine-grained local pathological changes. However, existing public resources do not support such unified multi-level analysis, often lacking full-hand coverage, fine-grained annotations, and consistent integration with clinical scoring systems. In particular, annotations that enable quantitative analysis of bone erosion (BE) remain scarce. RAM-H1200 contains 1,200 hand radiographs collected from six medical centers, with multi-level annotations including (i) whole-hand bone structure instance segmentation, (ii) pixel-level BE masks, (iii) SvdH-defined joint regions of interest, and (iv) joint-level SvdH scores for both BE and joint space narrowing (JSN). It is designed to evaluate whether models can jointly capture anatomical structure, localized erosive pathology, and clinically standardized RA severity from hand radiographs. The proposed BE masks enable, for the first time, quantitative BE analysis beyond coarse categorical grading by providing explicit spatial supervision for lesion extent and morphology. To our knowledge, RAM-H1200 is the first public large-scale benchmark that jointly supports whole-hand bone structure instance segmentation, pixel-level BE delineation, and clinically grounded joint-level SvdH scoring for both BE and JSN. Results across benchmark tasks show that anatomical modeling is substantially more mature than quantitative BE analysis: whole-hand bone segmentation achieves strong performance, whereas BE segmentation remains a major open challenge. By unifying anatomical structure modeling, quantitative lesion analysis, and clinically grounded SvdH scoring, RAM-H1200 provides a single benchmark for comprehensive RA analysis on hand radiographs.

Songxiao Yang, Haolin Wang, Yao Fu +9

Institute of Science Tokyo, Tokyo, Japan · Hokkaido University, Sapporo, Japan · Southwest Jiaotong University, Chengdu, China +2

Medical Imaging Medical Diagnosis Medical Image Segmentation Medical Image Benchmarks

May 6, 2026cs.CV

EchoXFlow: A Beamspace Echocardiography Dataset for Cardiac Motion, Flow, and Function

We introduce EchoXFlow, a clinical echocardiography dataset for learning from ultrasound in its native acquisition geometry rather than from scan-converted Cartesian videos. Existing public datasets offer limited opportunities to study cross-modal relationships between cardiac anatomy, myocardial motion, and blood flow, as Doppler is typically absent or fused as RGB overlays, and acquisitions are released after lossy vendor display processing. EchoXFlow comprises 37125 recordings from 666 routine-care examinations, preserving the timing, geometry, and modality relationships needed for physically grounded echo learning. Each recording is retained as separable modality-specific streams: temporally resolved 1D, 2D, and 3D data alongside multiple Doppler modalities, paired with a synchronized ECG. Clinical annotations span guideline-based measurements to dense 2D myocardial contours and 3D left-ventricular endocardial meshes. With its associated open-source tooling, EchoXFlow enables cross-modal, acquisition-aware learning tasks that cannot be formulated from conventional scan-converted videos alone, and serves as a testbed for 4D vision and physically grounded multi-modal learning more broadly.

Elias Stenhede, Joanna Sulkowska, Eivind Bjørkan Orstad +2

Medical Technology & E-Health, Akershus University Hospital, Norway · Department of Technology Systems, University of Oslo, Norway · Department of Cardiology, Akershus University Hospital, Norway

Medical Imaging Echocardiography Ultrasound Imaging Medical Image Benchmarks Multimodal Learning

May 5, 2026cs.CV

DALPHIN: Benchmarking Digital Pathology AI Copilots Against Pathologists on an Open Multicentric Dataset

Foundation models with visual question answering capabilities for digital pathology are emerging. Such unprecedented technology requires independent benchmarking to assess its potential in assisting pathologists in routine diagnostics. We created DALPHIN, the first multicentric open benchmark for pathology AI copilots, comprising 1236 images from 300 cases, spanning 130 rare to common diagnoses, 6 countries, and 14 subspecialties. The DALPHIN design and dataset are introduced alongside a human performance benchmark of 31 pathologists from 10 countries with varying expertise. We report results for two general-purpose (GPT-5, Gemini 2.5 Pro) and one pathology-specific copilot (PathChat+) for sequential and independent answer generation. We observed no statistically significant difference from expert-level performance in four of six tasks for PathChat, 2/6 tasks for Gemini, and 1/6 tasks for GPT. DALPHIN is publicly released with sequestered, indirectly accessible ground truth to foster robust and enduring benchmarking. Data, methods, and the evaluation platform are accessible through dalphin.grand-challenge.org.

Carlijn Lems, Sander Moonemans, Natálie Klubíčková +53

Computational Pathology Healthcare Medical VQA Pathology Foundation Models Medical Image Benchmarks

May 5, 2026cs.CV

MedSR-Vision: Deep Learning Framework for Multi-Domain Medical Image Super-Resolution

Medical image super-resolution (MedSR) is essential for improving diagnostic precision across diverse imaging modalities such as MRI, CT, X-ray, Ultrasound, and Fundus imaging. Despite rapid advances in deep learning, challenges remain in preserving anatomical accuracy, maintaining perceptual quality, and generalizing across medical domains. This paper presents MedSR-Vision, a novel unified deep learning framework for evaluating and comparing super-resolution models across five modalities: Brain MRI, Chest X-ray, Renal Ultrasound, Nephrolithiasis CT, and Spine MRI, at magnification scales of

\times2

,

\times3

, and

\times4

. Three representative models namely SRCNN, SwinIR, and Real-ESRGAN are benchmarked using multiple quantitative metrics encompassing fidelity, perceptual realism, and sharpness. Experimental analysis demonstrates that Real-ESRGAN achieves superior perceptual quality and edge recovery at higher scales, SwinIR excels in preserving structural and diagnostic features, and SRCNN provides efficient and stable performance at lower magnifications. The results establish domain-specific insights and practical guidelines for model selection in clinical imaging workflows, offering a standardized evaluation framework for future medical image super-resolution research and deployment.

Subhash Gurappa, Trivikram Satharasi, Yashas Hariprasad +1

Knight Foundation School of Computing and Information Sciences Florida International University Miami, FL 33199, USA · University of Florida Gainesville, FL 32611, USA · Department of Computer Science California State University, East Bay Hayward, CA 94542, USA

Medical Image Super-Resolution Medical Image Benchmarks

May 4, 2026cs.CV

NucEval: A Robust Evaluation Framework for Nuclear Instance Segmentation

In computational pathology, nuclear instance segmentation is a fundamental task with many downstream clinical applications. With the advent of deep learning, many approaches, including convolutional neural networks (CNNs) and vision transformers (ViTs), have been proposed for this task, along with both machine learning-based and non-machine learning-based pre- and post-processing techniques to further boost performance. However, one fundamental aspect that has received less attention is the evaluation pipeline. In this study, we identify four key issues associated with nuclear instance segmentation evaluation and propose corresponding solutions. Our proposed modifications, namely handling vague regions, score normalization, overlapping instances, and border uncertainty, are integrated into a unified framework called NucEval, which enables robust evaluation of nuclear instance segmentation. We evaluate this pipeline using the NuInsSeg dataset, which provides unique characteristics that make it particularly suitable for this study, as well as two additional external datasets, with three CNN- and ViT-based nuclear instance segmentation models, to demonstrate the impact of these modifications on instance segmentation metrics. The code, along with complete guidelines and illustrative examples, is publicly available at: https://github.com/masih4/nuc_eval.

Amirreza Mahbod, Ramona Woitek, Jeanne Shen

Research Center for Medical Image Analysis and Artificial Intelligence, Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, Krems an der Donau, Austria · Department of Pathology, Stanford University School of Medicine, USA · Center for Artificial Intelligence in Medicine & Imaging, Stanford University, USA

Computational Pathology Instance Segmentation Medical Image Benchmarks

May 4, 2026cs.CV

Scientific Domain Knowledge Improves Vision-Language Fundus Models

Vision-language models hold considerable promise for ophthalmology, but it remains unclear which training data source best conveys expert domain knowledge. Existing ophthalmic models are trained on fixed text templates, medical reports, or general biomedical literature, sources that have never been compared under matched conditions. To include domain-specific literature in this comparison, we present PubMed-Ophtha, a hierarchical dataset with high domain density of 102,023 panels with their subcaptions from 15,842 open-access articles in PubMed Central. We then finetuned identical CLIP models on each source, using a general biomedical literature model as baseline, and found that domain-specific literature achieved the best average performance across 110 clinical tasks, reaching a mean linear probing AUROC of 88.63% ahead of medical reports (85.68%). Restricting the dataset to fundus images, to the image count of the medical report dataset, or to articles unrelated to the evaluation datasets did not reduce performance, indicating that the gains likely stem from domain density. We release the dataset, the finetuned models, and the full generation pipeline.

Verena Jasmin Hallitschke, Carsten Eickhoff, Philipp Berens

1Hertie Institute for AI in Brain Health, University of Tübingen, Tübingen, Germany · Institute for Applied Medical Informatics, University of Tübingen, Tübingen, Germany · 2Tübingen AI Center, Tübingen, Germany

Healthcare Medical Diagnosis Medical VLMs Fundus Imaging Medical Image Benchmarks Vision-Language Pretraining

May 2, 2026cs.CL

OralMLLM-Bench: Evaluating Cognitive Capabilities of Multimodal Large Language Models in Dental Practice

Multimodal large language models (MLLMs) have emerged as a promising paradigm for dental image analysis. However, their ability to capture the multi-level cognitive processes required for radiographic analysis remains unclear. Here, we present a comprehensive benchmark to evaluate the cognitive capabilities of MLLMs in dental radiographic analysis. It spans three critical imaging modalities, i.e., periapical, panoramic, and lateral cephalometric radiographs, and defines four cognitive categories: perception, comprehension, prediction, and decision-making. The benchmark comprises 27 clinically grounded tasks derived from public datasets, with manually curated annotations and 3,820 clinician assessments for evaluation. Six frontier MLLMs, including GPT-5.2 and GLM-4.6, are evaluated. We demonstrate the performance gap between MLLMs and clinicians in dental practice, delineate model strengths and limitations, characterize failure patterns, and provide recommendations for improvement. This data resource will facilitate the development of next-generation artificial intelligence systems aligned with clinical cognition, safety requirements, and workflow complexity in dental practice.

Rongyang Wang, Shuang Zhou, Jiashuo Wang +2

Department of Orthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Fanjiacun Road #9, Fengtai District, Beijing 100070, China · Division of Computational Health Sciences, Department of Surgery, University of Minnesota, Minneapolis, MN, USA · Department of Computing, The Hong Kong Polytechnic University, Hong Kong SAR, China +1

Medical Imaging Cognitive Modeling Multimodal Large Language Models Multimodal Model Evaluation Medical Image Benchmarks

May 1, 2026eess.IV

Multi-frame Restoration for High-rate Lissajous Confocal Laser Endomicroscopy

Lissajous confocal laser endomicroscopy (CLE) is a promising solution for high speed in vivo optical biopsy for handheld scenarios. However, Lissajous scanning traces a resonant trajectory and samples only the visited pixels per frame; at high frame rates, many pixels remain unvisited, creating structured holes. In this work, we introduce the first benchmark for high-rate Lissajous CLE, consisting of low-quality video clips paired with high-quality reference images. The reference images are wide-FOV mosaics obtained by stitching stabilized, slow-scan frames of the same tissue, enabling temporally aligned supervision. Using this dataset, we propose MIRA, a lightweight recurrent framework for Lissajous CLE restoration that iteratively aggregates temporal context through feature reuse and displacement alignment. Our experiments demonstrate that MIRA outperforms both lightweight and high-complexity baselines in restoration quality while maintaining a favorable computational efficiency suitable for clinical deployment.

Minhee Lee, Sangyoon Lee, Jiwook Lee +4

POSTECH, Pohang, Republic of Korea · VPIX Medical, Seoul, Republic of Korea

Endoscopy Medical Imaging Recurrent Neural Networks Image Restoration Video Restoration Medical Image Benchmarks+1

May 1, 2026cs.CV

CURE-OOD: Benchmarking Out-of-Distribution Detection for Survival Prediction

``How long can I live and remain free of cancer?'' is often the first question a patient asks after receiving a cancer diagnosis and treatment. Accurate survival prediction helps alleviate psychological distress and supports risk stratification and personalized treatment planning. Recent survival prediction frameworks have shown strong performance using computed tomography (CT) images. However, variations in imaging acquisition introduce out-of-distribution (OOD) samples caused by covariate shifts that undermine model reliability. Despite this challenge, to our knowledge, no existing benchmark systematically studies OOD detection in cancer survival prediction. To address this gap, we introduce the Cancer sURvival bEnchmark for OOD Detection (CURE-OOD), the first benchmark for systematically evaluating OOD detection in survival prediction under controlled acquisition-induced distribution shifts. CURE-OOD defines scanner-parameter-based training, in-distribution (ID), and OOD test splits across four survival prediction tasks. Our experiments show that covariate shifts notably reduce survival prediction performance. It also shows that mainstream classification-oriented OOD detectors can fail in survival prediction. Finally, we include HazardDev as a simple survival-aware reference baseline for OOD detection. CURE-OOD enables systematic analysis of how distribution shifts affect both downstream survival performance and OOD detectability.

Wenjie Zhao, Jia Li, Mingrui Liu +2

University of Texas at Dallas · George Mason University · UT Southwestern Medical Center

Cancer Survival Prediction Distribution Shift Covariate Shift Oncology OOD Detection Medical Image Benchmarks

Apr 30, 2026cs.CV

MSR:Hybrid Field Modeling for CT-MRI Rigid-Deformable Registration of the Cervical Spine with an Annotated Dataset

Accurate CT-MRI registration of the cervical spine is essential for preoperative planning because this region is anatomically complex,highly variable,and vulnerable to injury of the vertebral arteries and spinal cord. However,cervical CT-MRI registration remains underexplored,particularly for rigid-deformable hybrid modeling,and the lack of high-quality annotated multimodal data further limits progress. To address these challenges, we construct and release a comprehensively annotated CT-MRI dataset, R-D-Reg, and propose MSR, a rigid-deformable hybrid registration framework for complex joint structures. Specifically, MSR includes a rigid registration module for independent local rigid alignment of individual vertebrae and a deformable registration module with an MSL block that combines Mamba-based global modeling and Swin Transformer-based local modeling through adaptive gating. The rigid and deformable deformation fields are then fused to generate a hybrid field that better preserves local anatomical consistency. The code and dataset are publicly available at https://github.com/ssc1230609-spec/MSR-registration.

Bohai Zhang, Wenjie Chen, Mu Li +8

School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China. · Guangdong Provincial Key Laboratory of Medical Image Processing, Guangzhou, 510515, China. · Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology Guangzhou, 510515, China. +2

Medical Imaging Medical Image Registration Deformable Image Registration Medical Image Benchmarks

Apr 30, 2026cs.CV

Assessing Pancreatic Ductal Adenocarcinoma Vascular Invasion: the PDACVI Benchmark

Surgical resection remains the only potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC), and eligibility depends on accurate assessment of vascular invasion (VI), i.e., tumor extension into adjacent critical vessels. Despite its importance for preoperative staging and surgical planning, computational VI assessment remains underexplored. Two major challenges are the lack of public datasets and the diagnostic ambiguity at the tumor-vessel interface, which leads to substantial inter-rater variability even among expert radiologists. To address these limitations, we introduce the CURVAS-PDACVI Dataset and Challenge, an open benchmark for uncertainty-aware AI in PDAC staging based on a densely annotated dataset with five independent expert annotations per scan. We also propose a multi-metric evaluation framework that extends beyond spatial overlap to include probabilistic calibration and VI assessment. Evaluation of six state-of-the-art methods shows that strong global volumetric overlap does not necessarily translate into reliable performance at clinically critical tumor-vessel interfaces. In particular, methods optimized for binary segmentation perform competitively on average overlap metrics, but often degrade in high-complexity cases with low expert consensus, either collapsing in volume or overextending at uncertain boundaries. In contrast, methods that model inter-rater disagreement produce better calibrated probabilistic maps and show greater robustness in these ambiguous cases. The benchmark highlights the limitations of volumetric accuracy as a proxy for localized surgical utility, motivating uncertainty-aware probabilistic models for preoperative decision-making.

M. Riera-Marín, O. K. Sikha, J. Rodríguez-Comas +23

BCN Medtech, Universitat Pompeu Fabra, Barcelona, Spain · Universitätsklinikum Erlangen, Department of Radiology of the Uniklinikum Erlangen (UKER), Erlangen, Germany · University Hospital Erlangen, Imaging Science Institute, Erlangen, Germany +10

Inter-Rater Reliability Medical Image Analysis Medical Image Segmentation Oncology Segmentation Uncertainty Estimation Medical Image Benchmarks

Apr 30, 2026cs.LG

AG-TAL: Anatomically-Guided Topology-Aware Loss for Multiclass Segmentation of the Circle of Willis Using Large-Scale Multi-Center Datasets

Accurate multiclass segmentation of the Circle of Willis (CoW) is essential for neurovascular disease management but remains challenging due to complex vascular topology and variable morphology. Existing deep learning methods often suffer from vascular discontinuities and inter-class misclassification, while current topological loss functions incur prohibitive computational costs in 3D multiclass settings. To address these limitations, we propose an Anatomically-Guided Topology-Aware Loss (AG-TAL) and introduce a large-scale, multi-center CoW dataset with unified annotations to facilitate robust model training. AG-TAL specifically integrates a radius-aware Dice loss to address class imbalance in small vessels, a breakage-aware clDice loss that utilizes group convolutions to efficiently preserve local connectivity, and an adjacency-aware co-occurrence loss that leverages anatomical priors to enforce distinct boundaries between neighboring arteries. Evaluated using 5-fold cross-validation, AG-TAL achieved an average Dice score of 80.85% for all CoW arteries, with small arteries notably higher by 1.05-3.09% compared to state-of-the-art methods. Across six independent datasets, the performance of AG-TAL achieved Dice scores ranging from 74.46% to 81.17% for all CoW arteries, with improvements of 2.20% to 9.98% for small arteries compared to other methods. This study demonstrates the superiority of AG-TAL in identifying multiclass CoW arteries and its ability to generalize well to multiple independent datasets. Furthermore, reliability analyses and clinical applications in an Alzheimer's disease cohort validate the AG-TAL's robustness and its potential for discovering imaging-based morphological biomarkers.

Jialu Liu, Yue Cui, Shan Yu

Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, China · State Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Chinese Academy of Sciences, Beijing, China · School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China +1

Medical Image Segmentation 3D Medical Image Segmentation Medical Image Benchmarks

Apr 29, 2026cs.LG

A Multi-Dataset Benchmark of Multiple Instance Learning for 3D Neuroimage Classification

Despite being resource-intensive to train, 3D convolutional neural networks (CNNs) have been the standard approach to classify CT and MRI scans. Recent work suggests that deep multiple instance learning (MIL) may be a more efficient alternative for 3D brain scans, especially when the pre-trained image encoder used to embed each 2D slice is frozen and only the pooling operation and classifier are trained. In this paper, we provide a systematic comparison of simple MIL, attention-based MIL, 3D CNNs, and 3D ViTs across three CT and four MRI datasets, including two large datasets of at least 10,000 scans. Our goal is to help resource-constrained practitioners understand which neural networks work well for 3D neuroimages and why. We further compare design choices for attention-based MIL, including different encoders, pooling operations, and architectural orderings. We find that simple mean pooling MIL, without any learnable attention, matches or outperforms recent MIL or 3D CNN alternatives on 4 of 6 moderate-sized tasks. This baseline remains competitive on two large datasets while being 25x faster to train. To explain mean pooling's success, we examine per-slice attention quality and a semi-synthetic dataset where we can derive the best possible classifier via a Bayes estimator. This analysis reveals the limits of existing MIL approaches and suggests routes for future improvements.

Ethan Harvey, Dennis Johan Loevlie, Amir Ali Satani +3

Department of Computer Science, Tufts University, Medford, MA, USA · Predictive Analytics and Comparative Effectiveness Center, Tufts Medical Center, Boston, MA, USA · Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA

3D ViTs Convolutional Neural Networks Neuroimaging Medical Image Benchmarks Multiple Instance Learning

Apr 28, 2026cs.LG

People-Centred Medical Image Analysis via Fairness-Aware Human-AI Cooperation

Machine learning models for medical image analysis often exhibit subgroup-dependent performance, which impacts how decisions should be allocated between automated systems and human experts under limited resources. Prior work on AI fairness and human-AI cooperation, including learning to defer (L2D) and learning to complement (L2C), typically addresses these problems in isolation. We propose People-Centred Medical Image Analysis (PecMan), a framework for fairness-aware human-AI co-operative classification that jointly models subgroup-dependent reliability, decision allocation, and collaborative prediction. PecMan combines subgroup-specialised predictors with a gating and consolidation mechanism that dynamically assigns cases to automated models, human experts, or their combination, without requiring sensitive attributes at test time. We also introduce the FairHAI benchmark for evaluating trade-offs between predictive accuracy, subgroup equity, and human involvement. In addition, we provide a theoretical analysis of multi-agent gating via selection regret and characterise fairness-coverage trade-offs under input-dependent allocation. Experiments across multiple medical imaging datasets demonstrate that PecMan achieves consistently improved trade-offs compared to methods that address fairness or human-AI cooperation separately.

Zheng Zhang, Milad Masroor, Cuong Nguyen +6

CVSSP, PAI, University of Surrey, UK · Southampton Solent University, UK · AIML, Adelaide University, Australia +2

Healthcare Learning to Defer Algorithmic Fairness Decision-Focused Learning Medical Image Classification Group Fairness+2

Apr 28, 2026cs.CV

Validation of Whole-Slide Foundation Models for Image Retrieval in TCGA Data

Foundation models are reshaping computational histopathology, yet their value for whole-slide image retrieval relative to strong patch-based and supervised aggregation baselines remains unclear. We benchmarked ten pipelines on 9,387 diagnostic slides spanning 17 organs and 60 diagnoses from The Cancer Genome Atlas (TCGA) using patient-level leave-one-patient-out evaluation. Methods included four pre-trained slide foundation models, a supervised attention-based multiple instance learning (ABMIL) aggregator on patch embeddings, and patch-level retrieval across five sampling densities. Performance varied more across organs and diagnoses than across architectures. Although the slide foundation model TITAN achieved the strongest overall results, its advantage was modest; ABMIL and patch-based methods reached comparable Top-1 and Top-3 accuracy, with no model consistently dominant. Morphologically distinctive entities approached ceiling performance, while rare, heterogeneous, and closely related subtypes remained challenging. Misclassifications aligned with organs exhibiting known inter-observer variability, suggesting an intrinsic ceiling for morphology-only retrieval. Performance was driven primarily by patch-level feature representations, with limited benefit from slide-level aggregation, indicating aggregation may be unnecessary in many settings. These findings argue against a universally optimal architecture and instead support organ-resolved benchmarking, diagnosis-aware or ensemble strategies, stronger feature representations, and multimodal retrieval frameworks. Notably, even the best model achieved only

\approx 68\% \pm 21\%

retrieval accuracy on TCGA, and some subtypes showed

0\%

accuracy across all methods, highlighting fundamental limitations of morphology-based representations and the need for substantial progress before reliable clinical deployment.

Tianhao Lei, Parsa Esmaeilkhani, Saghir Alfasly +5

KIMIA Lab, Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN, USA. · Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. · Department of Computer Science, Temple University, Philadelphia, PA, USA. +2

Pathology Foundation Models Oncology Medical Image Benchmarks Multiple Instance Learning Whole-Slide Image Analysis

Apr 28, 2026eess.IV

Robustness Evaluation of a Foundation Segmentation Model Under Simulated Domain Shifts in Abdominal CT: Implications for Health Digital Twin Deployment

Foundation segmentation models such as the Segment Anything Model (SAM) have demonstrated strong generalization across natural images; however, their robustness under clinically realistic medical imaging domain shifts remains insufficiently quantified. We present a systematic slice-level robustness audit of SAM (ViT-B) for spleen segmentation in abdominal CT using 1,051 nonempty slices from 41 volumes in the Medical Segmentation Decathlon. A standardized ground-truth-derived bounding-box protocol was used to isolate encoder robustness from prompt uncertainty. Controlled perturbations simulating inter-scanner variability, including Gaussian noise, blur, contrast scaling, gamma correction, and resolution mismatch, were applied across ten conditions. The clean baseline achieved a mean Dice score of 0.9145 (95% CI: [0.909, 0.919]) with a failure rate of 0.67%. Across all perturbations, the absolute mean ΔDice remained below 0.01. Paired Wilcoxon signed-rank tests with Benjamini-Hochberg false discovery rate correction identified statistically significant but small-magnitude changes under selected conditions, while McNemar analysis showed no significant increase in failure probability. These findings indicate that SAM exhibits stable segmentation behavior under moderate CT domain shifts, supporting its role as a robust foundation baseline for medical image segmentation research. As health digital twins increasingly incorporate foundation segmentation models for anatomical modeling and organ-level monitoring, formal characterization of robustness under real-world imaging variability is a necessary step toward trustworthy deployment.

Sanghati Basu

Healthcare Informatics, University of Illinois Springfield

Distribution Shift Robustness Image Segmentation Medical Imaging Foundation Models Image Corruption Robustness Medical Image Segmentation Computed Tomography+1

Apr 27, 2026cs.CV

BifDet: A 3D Bifurcation Detection Dataset for Airway-Tree Modeling

Thoracic Computed Tomography (CT) scans offer detailed insights into the intricate branching network of the airway tree, which is essential for understanding various respiratory diseases. Airway bifurcations, where airway branches split, are crucial landmarks for understanding lung physiology, disease mechanisms and lesion localization. Despite the significance of bifurcation analysis, a notable lack of datasets annotated for this task hinders the development of advanced automated specialized detection or segmentation tools. In this paper, we introduce BifDet, the first publicly-available dataset specialized for 3D airway bifurcation detection, filling a critical gap in existing resources. Our dataset comprises carefully annotated CT scans from the ATM22 open-access cohort with bifurcation bounding boxes covering the parent and daughter branches. As a use-case for demonstrating the potential of BifDet, we fine-tune and evaluate RetinaNet and DETR for 3D airway bifurcations detection on CT scans. We provide detailed pipelines, including preprocessing steps and specific implementation design choices. Results are detailed over various categories of minimal bounding box sizes to serve as baseline to benchmark future research.

Ali Keshavarzi, Quentin Bouniot, Benjamin M. Smith +1

LTCI, Telecom Paris, Insitut Polytechnique de Paris, Palaiseau, France · Department of Medicine, Columbia University, New York, USA

3D Object Detection Medical Image Benchmarks

Apr 27, 2026cs.CV

Benchmarking Pathology Foundation Models for Breast Cancer Survival Prediction

Pathology foundation models (PFMs) have recently emerged as powerful pretrained encoders for computational pathology, enabling transfer learning across a wide range of downstream tasks. However, systematic comparisons of these models for clinically meaningful prediction problems remain limited, especially in the context of survival prediction under external validation. In this study, we benchmark widely used and recently proposed PFMs for breast cancer survival prediction from whole-slide histopathology images. Using a standardized pipeline based on patch-level feature extraction and a unified survival modeling framework, we evaluate model representations across three independent clinical cohorts comprising more than 5,400 patients with long-term follow-up. Models are trained on one cohort and evaluated on two independent external cohorts, enabling a rigorous assessment of cross-dataset generalization. Overall, H-optimus-1 achieves the strongest survival prediction performance. More broadly, we observe consistent generational improvements across model families, with second-generation PFMs outperforming their first-generation counterparts. However, absolute performance differences between many recent PFMs remain modest, suggesting diminishing returns from further scaling of pretraining data or model size alone. Notably, the compact distilled model H0-mini slightly outperforms its larger teacher model H-optimus-0, despite using fewer than 8% of the parameters and enabling significantly faster feature extraction. Together, these results provide the first large-scale, externally validated benchmark of PFMs for breast cancer survival prediction, and offer practical guidance for efficient deployment of PFMs in clinical workflows.

Fredrik K. Gustafsson, Constance Boissin, Johan Vallon-Christersson +2

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden · Division of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden · Department of Engineering Science, University of Oxford, Oxford, UK +1

Cancer Survival Prediction Survival Analysis Pathology Foundation Models Oncology Medical Image Benchmarks Whole-Slide Image Analysis

Apr 27, 2026cs.AI

CT-FineBench: A Diagnostic Fidelity Benchmark for Fine-Grained Evaluation of CT Report Generation

The evaluation of generated reports remains a critical challenge in Computed Tomography (CT) report generation, due to the large volume of text, the diversity and complexity of findings, and the presence of fine-grained, disease-oriented attributes. Conventional evaluation metrics offer only coarse measures of lexical overlap or entity matching and fail to reflect the granular diagnostic accuracy required for clinical use. To address this gap, we propose CT-FineBench, a benchmark built from CT-RATE and Merlin to evaluate the fine-grained factual consistency of CT reports, constructed from CT-RATE and Merlin. Our benchmark is constructed through a meticulous, Question-Answering (QA) based process: first, we identify and structure key, finding-specific clinical attributes (like location, size, margin). Second, we systematically transform these attributes into a QA dataset, where questions probe for specific clinical details grounded in gold-standard reports. The evaluation protocol for CT-FineBench involves using this QA dataset to query a machine-generated report and scoring the correctness of the answers. This allows for a comprehensive, interpretable, and clinically-relevant assessment, moving beyond superficial lexical overlap to pinpoint specific clinical errors. Experiments show that CT-FineBench correlates better with expert clinical assessment and is substantially more sensitive to fine-grained factual errors than prior metrics.

Ruifeng Yuan, Wanxing Chang, Weiwei Cao +4

DAMO Academy, Alibaba Group, China · Hupan Lab, 310023, China · Fudan University, China +2

Radiology Report Generation Medical Report Generation Factual Consistency Evaluation Computed Tomography Medical Image Benchmarks Radiology Report Evaluation

Apr 25, 2026cs.LG

GAZE: Grounded Agentic Zero-shot Evaluation with Viewer-Level Tools and Literature Retrieval on Rare Brain MRI

Vision-language models (VLMs) read an image and produce text in a single forward pass, whereas radiologists typically inspect an image several times and consult the literature before writing a report. We introduce GAZE (Grounded Agentic Zero-shot Evaluation), a framework that lets a medical VLM work in this iterative way by calling viewer-level tools (zoom, windowing, contrast, edge detection) and two retrieval tools backed by the U.S. National Library of Medicine (PubMed for medical literature, Open-i for radiological images), with structured outputs validated against a schema and full tool-call traces recorded for auditability. On NOVA, a benchmark of 906 brain MRI cases covering 281 rare neurological conditions, GAZE reaches 58.2 mean average precision (mAP) at intersection-over-union (IoU) 0.3 for lesion localisation and 34.9% Top-1 diagnostic accuracy under a joint protocol that scores captioning, diagnosis, and localisation from the image alone, without task-specific fine-tuning. Before any tool is used, structured prompting and schema-validated outputs already improve over the published Gemini 2.0 Flash baseline (20.2 to 29.4 [email protected]), so framework design is itself an experimental variable. Tool use helps rare pathologies disproportionately: the fraction of cases with IoU > 0.3 rises from 17% to 58% for diagnoses with three or fewer examples versus 25% to 68% for common conditions (

\geq

10 cases), with gains tracking engagement (Gemini 3 Flash: Cohen's d = 0.79, 11.8 tool calls per case; Gemini 2.0 Flash: tools used in 8.2% of cases, no significant benefit). Retrieval ablations additionally reveal a model-dependent trade-off in which gains in diagnosis can coincide with losses in localisation, reinforcing the case for joint evaluation of diagnosis, localisation, and captioning in medical VLMs.

Duaa Alim, Mogtaba Alim, Liam Chalcroft

Imperial College London, UK · University of Toronto, Canada · University College London, UK

VLM Evaluation Rare Disease Diagnosis Healthcare Tool-Using Vision-Language Agents Medical Image Localization Medical Image Benchmarks

Apr 25, 2026cs.CV

DyABD: The Abdominal Muscle Segmentation in Dynamic MRI Benchmark

This work introduces DyABD, a novel and complex benchmark dataset of dynamic abdominal MRIs from patients with abdominal hernias and associated high quality abdominal muscle annotations. DyABD is the first-of-its-kind in four key ways; (1) it proposes the first abdominal muscle segmentation task, (2) the dynamic MRIs are acquired whilst the patients perform various exercises, introducing extreme anatomical variability, making it one of the most challenging segmentation datasets to date, (3) it includes both pre and post corrective MRIs and (4) DyABD promotes clinical research into the high recurrence rates of abdominal hernias. Beyond dataset introduction, this work provides a comprehensive evaluation of the generalisation capabilities of existing segmentation models across Supervised, Few Shot and Zero Shot paradigms on the unseen DyABD dataset. This work reveals that there is still room for substantial improvement in the field of medical image segmentation, with the majority of techniques achieving a Dice Coefficient of 0.82. This work therefore sheds light on the true progress of the field and redefines the benchmark for progress in medical image segmentation.

Niamh Belton, Victoria Joppin, Aonghus Lawlor +4

School of Medicine, University College Dublin, Dublin, Ireland. · Science Foundation Ireland Centre for Research Training in Machine2026 Learning, Dublin, Ireland. · Aix Marseille Univ, Univ Gustave Eiffel, LBA, Marseille France. +4

Image Segmentation Magnetic Resonance Imaging Medical Image Segmentation Few-Shot Medical Image Segmentation Medical Image Benchmarks

Apr 24, 2026cs.CV

NeuroAPS-Net: Neuro-Anatomically Aware Point Cloud Representation for Efficient Alzheimer's Disease Classification

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major cause of dementia. Structural MRI is widely used to analyze AD-related brain atrophy; however, most deep learning methods rely on computationally expensive 3D convolutional neural networks (CNNs), limiting deployment in resource-constrained settings. This work introduces two main contributions. First, we propose a pipeline that converts T1-weighted MRI into anatomically informed 2D point clouds using Anatomical Priority Sampling (APS), producing ADNI-2DPC, the first neuroanatomically labeled MRI-derived point cloud dataset. Second, we present NeuroAPS-Net, a lightweight geometric deep learning model that incorporates anatomical priors via region-aware feature encoding and ROI token aggregation. Experiments on ADNI-2DPC demonstrate that NeuroAPS-Net achieves competitive classification accuracy while significantly reducing inference latency and GPU memory compared to state-of-the-art point cloud methods. These results highlight the potential of anatomically guided point cloud learning as an efficient and interpretable alternative to voxel-based CNNs for AD classification.

Towhidul Islam, Mufti Mahmud

ICS Department, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia · SDAIA-KFUPM JRC for AI, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia · IRC for Bio Systems and Machines, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia

Efficient Neural Network Inference Point Cloud Classification Medical Image Classification Alzheimer's Disease Classification Medical Image Benchmarks

Apr 22, 2026cs.CV

A Digital Pathology Resource for Liver Cancer Quantification with Datasets, Benchmarks, and Tools

Liver cancer, especially hepatocellular carcinoma (HCC), imposes a substantial global disease burden. Accurate diagnosis and prognostic assessment directly influence treatment selection and patient survival, and pathological examination remains the gold standard for liver cancer diagnosis. Identifying diverse tissue components and pathological subtypes on histopathology slides is crucial for estimating postoperative recurrence risk and overall prognosis. However, most publicly available resources are still provided at the whole-slide image (WSI) level, and well-annotated datasets for fine-grained tissue component identification in liver cancer are scarce, which hinders reproducible model development and the deployment of quantitative analysis tools. To address this gap, we release HepatoBench, a patch-level image database for liver cancer with annotations for seven key tissue categories. Based on HepatoBench, we train and open-source a deep learning classification model as a tissue recognition tool. Furthermore, we train a WSI-level tumor/non-tumor segmentation model to automatically localize lesion regions across entire slides. By integrating the patch-level tissue classifier with the WSI-level segmentation model, we build HepatoQuant, an end-to-end, disease-specific regional quantification tool for liver cancer, enabling a unified workflow from WSIs to tissue composition parsing and quantitative statistics. We also open-source HepatoBench, the benchmarking protocol, and supporting tools, providing a solid foundation for automated regional quantification and fair method comparison in liver cancer pathology.

Ying Xiao, Shimiao Tang, Xitong Ling +11

Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China · Shenzhen International Graduate School, Tsinghua University, Shenzhen, China

Computational Pathology Image Segmentation Histopathology Image Segmentation Oncology Histopathology Image Classification Medical Image Benchmarks+1

Apr 22, 2026cs.CV

X-PCR: A Benchmark for Cross-modality Progressive Clinical Reasoning in Ophthalmic Diagnosis

Despite significant progress in Multi-modal Large Language Models (MLLMs), their clinical reasoning capacity for multi-modal diagnosis remains largely unexamined. Current benchmarks, mostly single-modality data, can't evaluate progressive reasoning and cross-modal integration essential for clinical practice. We introduce the Cross-Modality Progressive Clinical Reasoning (X-PCR) benchmark, the first comprehensive evaluation of MLLMs through a complete ophthalmology diagnostic workflow, with two reasoning tasks: 1) a six-stage progressive reasoning chain spanning image quality assessment to clinical decision-making, and 2) a cross-modality reasoning task integrating six imaging modalities. The benchmark comprises 26,415 images and 177,868 expert-verified VQA pairs curated from 51 public datasets, covering 52 ophthalmic diseases. Evaluation of 21 MLLMs reveals critical gaps in progressive reasoning and cross-modal integration. Dataset and code: https://github.com/CVI-SZU/X-PCR.

Gui Wang, Zehao Zhong, YongSong Zhou +6

School of Computer Science and Software Engineering, Shenzhen University · 2Tsinghua University · 5Wenzhou Medical University +3

Healthcare Medical Diagnosis Medical VQA Clinical Reasoning Multimodal Model Evaluation Medical Image Benchmarks

Apr 20, 2026cs.CV

CrossPan: A Comprehensive Benchmark for Cross-Sequence Pancreas MRI Segmentation and Generalization

Automatic pancreas segmentation is fundamental to abdominal MRI analysis, yet deep learning models trained on one MRI sequence often fail catastrophically when applied to another-a challenge that has received little systematic investigation. We introduce CrossPan, a multi-institutional benchmark comprising 1,386 3D scans across three routinely acquired sequences (T1-weighted, T2-weighted, and Out-of-Phase) from eight centers. Our experiments reveal three key findings. First, cross-sequence domain shifts are far more severe than cross-center variability: models achieving Dice scores above 0.85 in-domain collapse to near-zero (<0.02) when transferred across sequences. Second, state-of-the-art domain generalization methods provide negligible benefit under these physics-driven contrast inversions, whereas foundation models like MedSAM2 maintain moderate zero-shot performance through contrast-invariant shape priors. Third, semi-supervised learning offers gains only under stable intensity distributions and becomes unstable on sequences with high intra-organ variability. These results establish cross-sequence generalization-not model architecture or center diversity-as the primary barrier to clinically deployable pancreas MRI segmentation. Dataset and code are available at https://crosspan.netlify.app/.

Linkai Peng, Cuiling Sun, Zheyuan Zhang +10

Department of Radiology, Northwestern University, Chicago, USA. · Department of Electrical and Computer Engineering, Northwestern University, Evanston, USA. · Department of Computer Science, Northwestern University, Evanston, USA. +4

Image Segmentation Magnetic Resonance Imaging Medical Image Segmentation 3D Medical Image Segmentation Medical Image Benchmarks

Apr 20, 2026cs.CV

Region-Grounded Report Generation for 3D Medical Imaging: A Fine-Grained Dataset and Graph-Enhanced Framework

Automated medical report generation for 3D PET/CT imaging is fundamentally challenged by the high-dimensional nature of volumetric data and a critical scarcity of annotated datasets, particularly for low-resource languages. Current black-box methods map whole volumes to reports, ignoring the clinical workflow of analyzing localized Regions of Interest (RoIs) to derive diagnostic conclusions. In this paper, we bridge this gap by introducing VietPET-RoI, the first large-scale 3D PET/CT dataset with fine-grained RoI annotation for a low-resource language, comprising 600 PET/CT samples and 1,960 manually annotated RoIs, paired with corresponding clinical reports. Furthermore, to demonstrate the utility of this dataset, we propose HiRRA, a novel framework that mimics the professional radiologist diagnostic workflow by employing graph-based relational modules to capture dependencies between RoI attributes. This approach shifts from global pattern matching toward localized clinical findings. Additionally, we introduce new clinical evaluation metrics, namely RoI Coverage and RoI Quality Index, that measure both RoI localization accuracy and attribute description fidelity using LLM-based extraction. Extensive evaluation demonstrates that our framework achieves SOTA performance, surpassing existing models by 19.7% in BLEU and 4.7% in ROUGE-L, while achieving a remarkable 45.8% improvement in clinical metrics, indicating enhanced clinical reliability and reduced hallucination. Our code and dataset are available on GitHub.

Cong Huy Nguyen, Son Dinh Nguyen, Guanlin Li +8

AI4LIFE, Hanoi University of Science and Technology, Vietnam · SAMOVAR, Télécom SudParis, Institut Polytechnique de Paris, France · Military Central Hospital, Vietnam

Radiology Report Generation Medical Report Generation PET/CT Imaging Medical Image Grounding Medical Image Benchmarks

Apr 19, 2026cs.CV

PBSBench: A Multi-Level Vision-Language Framework and Benchmark for Hematopathology Whole Slide Image Interpretation

Peripheral Blood Smear (PBS) is a critical microscopic examination in hematopathology that yields whole-slide imaging (WSI). Unlike solid tissue pathology, PBS interpretation focuses on individual cell morphologies rather than tissue architecture, making it distinct in both visual characteristics and diagnostic reasoning. However, current multimodal large language models (MLLMs) for pathology are primarily developed on solid-tissue WSIs and struggle to generalize to PBS. To bridge this gap, we construct PBSInstr, the first vision-language dataset for PBS interpretation, comprising 353 PBS WSIs paired with microscopic impression paragraphs and 29k cell-level image crops annotated with cell type labels and morphological descriptions. To facilitate instruction tuning, PBSInstr further includes 27k question-answer (QA) pairs for cell crops and 1,286 QA pairs for PBS slides. Building upon PBSInstr, we develop PBS-VL, a hematopathology-tailored vision-language model for multi-level PBS interpretation at both cell and slide levels. To comprehensively evaluate PBS understanding, we construct PBSBench, a visual question answering (VQA) benchmark featuring four question categories and six PBS interpretation tasks. Experiments show that PBS-VL outperforms existing general-purpose and pathology MLLMs, underscoring the value of PBS-specific data. We release our code, datasets, and model weights to facilitate future research. Our proposed framework lays the foundation for developing practical AI assistants supporting decision-making in hematopathology.

Yuanlong Wang, Weichi Chen, Adrian Rajab +4

The Ohio State University · The Ohio State University Wexner Medical Center

Computational Pathology Medical VQA Medical VLMs Medical Image Benchmarks Whole-Slide Image Analysis

Apr 19, 2026eess.IV

VIDS: A Verified Imaging Dataset Standard for Medical AI

Medical imaging AI development is fundamentally dependent on annotated datasets, yet no existing standard provides machine-enforceable validation across dataset structure, annotation provenance, quality documentation, and ML readiness within a single framework. DICOM standardizes image acquisition, storage, and communication at the individual study level. BIDS organizes neuroimaging research datasets with consistent naming conventions. Neither addresses the curation layer, viz., who annotated what, when, with what tool, and to what quality standard. This paper presents VIDS (Verified Imaging Dataset Standard), an open specification that defines folder layout, file naming, annotation provenance schemas, quality documentation, and 21 machine-enforceable validation rules across two compliance profiles. VIDS uses NIfTI as a canonical working format while preserving full DICOM metadata in sidecars for traceability, and supports export to any downstream ML framework (nnU-Net, MONAI, COCO, flat NIfTI) without loss of provenance. Twenty-two compliance dimensions are defined and four major public datasets -- LIDC-IDRI, BraTS, CheXpert, and the Medical Segmentation Decathlon -- are benchmarked against these dimensions. Even widely used datasets satisfy only 20--39% of these dimensions, with provenance and quality documentation as the largest systematic gaps. LIDC-Hybrid-100 is released as a 100-subject VIDS-compliant reference CT dataset with consensus segmentation masks from four radiologist annotations (mean pairwise Dice 0.7765), validating 21/21 on the Full compliance profile. VIDS is fully open source: the specification is CC BY 4.0, all tools are Apache 2.0, the reference validator is available on PyPI (pip install vids-validator), and LIDC-Hybrid-100 is published on Zenodo (https://doi.org/10.5281/zenodo.19582717).

Joan S. Muthu, John Shalen

Princeton Medical Systems

Medical Imaging Training Data Curation Medical Image Benchmarks

Apr 17, 2026cs.CV

Agentic Large Language Models for Training-Free Neuro-Radiological Image Analysis

State-of-the-art large language models (LLMs) show high performance in general visual question answering. However, a fundamental limitation remains: current architectures lack the native 3D spatial reasoning required to directly analyze volumetric medical imaging, such as CT or MRI. Emerging agentic AI offers a new solution, eliminating the need for intrinsic 3D processing by enabling LLMs to orchestrate and leverage specialized external tools. Yet, the feasibility of such agentic frameworks in complex, multi-step radiological workflows remains underexplored. In this work, we present a training-free agentic pipeline for automated brain MRI analysis. Validating our methodology on several LLMs (GPT-5.4, Gemini 3.1 Pro, Claude Sonnet 4.6) with off-the-shelf domain-specific tools, our system autonomously executes complex end-to-end workflows, including preprocessing (skull stripping, registration), pathology segmentation (glioma, meningioma, metastases), and volumetric reasoning. We evaluate our framework across increasingly complex radiological tasks, from single-scan tumor and anatomy analysis to longitudinal response assessment requiring multi-timepoint comparisons. We analyze the impact of architectural design by comparing single-agent models against multi-agent "domain-expert" collaborations. To support rigorous evaluation of future agentic systems, we release a benchmark dataset of image-prompt-answer tuples derived from public data. Our results demonstrate that agentic AI can solve highly neuro-radiological image analysis tasks through tool use without the need for training or fine-tuning.

Ayhan Can Erdur, Daniel Scholz, Jiazhen Pan +3

Department of Radiation Oncology, TUM University Hospital, Munich, Germany · Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany · Chair for AI for Image-Guided Diagnosis and Therapy, Technical University of Munich (TUM) and TUM University Hospital, Munich, Germany +3

Medical Image Analysis Longitudinal Medical Image Analysis LLM Tool Use Multi-Agent LLMs Medical Image Benchmarks Brain MRI+1

Apr 17, 2026cs.CV

Beyond a Single Frame: Multi-Frame Spatially Grounded Reasoning Across Volumetric MRI

Spatial reasoning and visual grounding are core capabilities for vision-language models (VLMs), yet most medical VLMs produce predictions without transparent reasoning or spatial evidence. Existing benchmarks also evaluate VLMs on isolated 2D images, overlooking the volumetric nature of clinical imaging, where findings can span multiple frames or appear on only a few slices. We introduce Spatially Grounded MRI Visual Question Answering (SGMRI-VQA), a 41,307-pair benchmark for multi-frame, spatially grounded reasoning on volumetric MRI. Built from expert radiologist annotations in the fastMRI+ dataset across brain and knee studies, each QA pair includes a clinician-aligned chain-of-thought trace with frame-indexed bounding box coordinates. Tasks are organized hierarchically across detection, localization, counting/classification, and captioning, requiring models to jointly reason about what is present, where it is, and across which frames it extends. We benchmark 10 VLMs and show that supervised fine-tuning of Qwen3-VL-8B with bounding box supervision consistently improves grounding performance over strong zero-shot baselines, indicating that targeted spatial supervision is an effective path toward grounded clinical reasoning.

Lama Moukheiber, Caleb M. Yeung, Haotian Xue +3

Georgia Institute of Technology · Harvard University · Georgetown University

3D Spatial Reasoning 3D Medical Imaging Medical VQA Visually Grounded Reasoning Medical Image Grounding Medical Image Benchmarks