Multimodal Foundation Model

Earth observation is inherently dynamic, yet temporal information in many foundation models is learned through reconstruction, invariance, or retrospective sequence summarization. SPEAR NeXT is introduced as a compact pixel-wise multimodal spectral temporal foundation model in which temporal self supervision is formulated as past only, multi horizon latent Earth state prediction. Instantaneous states are first encoded by the pretrained SPEAR model from optical, radar, and environmental observations into compact 32 dimensional embeddings. Their temporal evolution is then modeled by a causally masked Trans former that predicts multiple future latent states from pre ceding observations. Relative temporal order is represented using Rotary Position Embeddings, while month and year embeddings encode seasonal phase and interannual con text.

Brain signal analysis is essential for both neuroscience research and clinical diagnostics, yet current approaches face critical limitations. End-to-end models require task-specific retraining and exhibit limited generalization, while pre-trained models lack semantic depth and still depend on extensive fine-tuning. Meanwhile, general-purpose multimodal foundation models, though powerful in other domains, struggle to interpret brain signals due to representational misalignment and lack of domain knowledge. This study introduces a multimodal foundation model for zero-shot and multi-task brain signal analysis (METIS) through a unified language-signal alignment framework. METIS is pretrained on the largest and most diverse brain-signal corpus to date, comprising over 70,000 h of recordings from more than 11,000 subjects across 20 datasets. In a comprehensive zero-shot evaluation across 12 datasets, METIS outperformed the leading generalist model by over 20.9% in average accuracy. Remarkably, without any fine-tuning, METIS's performance matches or exceeds that of supervised, task-specific models. Furthermore, METIS demonstrates exceptional data efficiency and strong generalization, achieving an average AUROC advantage of over 16.0% in few-shot settings and 15.9% in cross-dataset transfer. This work establishes a new paradigm for general-purpose brain signal analysis, paving the way for next-generation neurotechnology.

Speech-based Alzheimer's disease (AD) detection has recently benefited from multimodal foundation-model representations that integrate complementary acoustic and linguistic information. However, conventional probability averaging over these complementary classifiers is unreliable, because their posterior probabilities exhibit mismatched scales: identical values may reflect different confidence levels across models. We propose a robust rank aggregation framework that aggregates normalized prediction ranks instead of posterior probabilities. Each subject is scored by its percentile within a fixed training-cohort distribution of out-of-fold predictions; since rank ordering is invariant to monotonic transformations, this avoids probability-scale mismatch while preserving classifier confidence ordering. A confidence-gated Random Forest further corrects residual errors using clinically interpretable linguistic features, overriding the rank prediction only when the two disagree and the RF is highly confident, without additional deep model training or explicit posterior-probability calibration. On ADReSS2020 and ADReSSo2021, the method achieves accuracies of 95.83% and 90.14%, respectively, comparing favorably with previously reported results.

Building an omni-modal foundation model means evaluating it across text, image, video, and audio. Excellent evaluation toolkits exist for each modality, but their inference engines, prompt conventions, and metric implementations are mutually incompatible, so practitioners end up maintaining separate environments for every toolchain and still struggle to compare results across them. OmniEvaluator grew out of this need in our own model development: rather than reimplementing benchmarks, it connects existing inference engines and curated evaluation libraries at a higher level, exposing four inference backends, four evaluation frameworks, and over a thousand benchmarks through a single interface. Every run is recorded as an artifact capturing the full configuration for exact reproduction, and results flow into a shared dashboard for cross-model comparison. A federated mode shares GPU inference servers across concurrent evaluations, and a built-in verifier, small enough to run on CPU, keeps its score stable across engines and prompts where rule-based scoring fluctuates under configuration mismatch, matching cost-efficient commercial LLM judges without their recurring API cost. The system, demo video, and dashboard are publicly available. (https://github.com/naver-ai/omni-evaluator)

Scientific discovery increasingly requires AI systems that can reason over scientific evidence of heterogeneous modalities, interact with scientific tools and environments, and sustain progress across long task horizons. We present Intern-S2-Preview, a series of scientific agentic foundation models designed to support multimodal scientific understanding, reasoning, generation, and long-horizon tasks. The training pipeline begins with scientific multimodal pre-training over rendered scientific documents, interleaved image-text data, and diverse scientific corpora. Starting from the pretrained checkpoint, we apply a unified post-training pipeline consisting of supervised fine-tuning, scalable multi-task reinforcement learning (RL), black- and white-box agentic RL, and on-policy distillation. This pipeline is supported by practical techniques that improve rollout and training stability and efficiency, including partial rollout with off-policy correction, adaptive length regularization, online speculative decoding, robust multi-task optimization, and trace-aware experience assembly for agentic tasks. At the architecture level, Intern-S2-Preview-397B extends time series modelling from efficient long-sequence understanding to numerical forecasting, while Memory Decoder is studied as a separate memory-augmented path for rapid scientific specialization without modifying the frozen 397B backbone. Evaluations across scientific, multimodal, agentic, and general-purpose benchmarks show that Intern-S2-Preview-397B achieves competitive or leading results in multiple settings. The time series modules improve scientific signal understanding and forecasting on SciTS, while the separate Intern-MemDec-4B extension improves the Biology-Instructions average score from 56.92 to 60.32 without modifying the frozen 397B backbone.

Spatial transcriptomics can resolve gene expression at single-cell resolution, but it is costly, limited to targeted panels of a few hundred to a few thousand genes, and applicable to only a small number of samples. H&E imaging, by contrast, is cheap and collected routinely at scale. This makes predicting single-cell expression directly from morphology a practical way to bring molecular analysis to large tissue archives. We therefore present VOICE, a multimodal foundation model that predicts single-cell gene expression from H&E images using paired Xenium data. VOICE first aligns cell centered H&E morphology from a pathology foundation model with single-cell expression embeddings from a transcriptome foundation model, trained using contrastive learning over 23 million cells. Next it predicts expression through two branches. One branch directly regresses expression from morphology. The other branch retrieves measured expression from similar reference cells, recovering genes that do not have morphological signal. Because genes vary in morphological predictability, VOICE fuses the two branches with a per-gene weight. After training, VOICE generalizes to heldout patients, slides, and partially overlapping gene panels from Xenium, and it consistently outperforms prior single-cell expression prediction methods on seven metrics.

Automating industrial CAD design and manufacturing places distinctive demands on multimodal foundation models: the model must see engineering drawings and 3D geometry screenshots, write correct parametric-modelling scripts and Windows COM API code, and cover the full range from single parts to assemblies. General-purpose multimodal models fall short on these tasks, while single-task fine-tuning is too narrow to support the diverse calls that upper-layer agents issue. We build IndustryForge-27B on top of Qwen3.5-VL-27B by curating and integrating six industrial-CAD sub-corpora totalling $\sim$52k multimodal samples---CAD Visual QA (CAD-VQA), parametric CAD code (text2cadquery), assembly-level CAD code (text2cadquery-assembly), and three COM sub-corpora for Inventor / SolidWorks (com_2d / com_3d / com_assembly)---and training with a unified multi-task SFT recipe. Across four CAD-domain benchmarks IndustryForge-27B lifts the base model by $+33.65$~pp on average and outperforms the strong closed-source model GPT-5.4 on all four; across eleven general-capability benchmarks it retains, and slightly improves upon, the base model ($+1.56$~pp mean, no catastrophic forgetting). IndustryForge-27B will serve as the common substrate for downstream industrial-agent projects, providing a unified starting point for a full-stack industrial agent that spans from CAD design to industrial-software operation, from parts to assemblies, and from single-shot generation to closed-loop self-improvement.

Multimodal foundation models are reshaping edge-cloud visual intelligence from task-specific feature pipelines into token-based interfaces, where edge devices encode visual inputs into tokens for a general-purpose cloud MLLM. However, dense visual-token sequences increase cloud-side inference costs. Existing pruning methods mainly target centralized inference: vision-driven methods can operate before cloud execution but are typically query-agnostic, whereas query-guided methods often rely on internal states of the target MLLM and cannot determine token relevance before transmission. Compact guidance models offer an alternative, but existing designs may require costly attention aggregation or auxiliary generation. We propose LAST, a training-free framework for query-dependent visual token pruning in edge-cloud collaborative MLLM inference. LAST uses a compact edge-side VLM as a guidance proxy and derives a lightweight importance signal from the last query token's attention to visual tokens. Under causal attention, the last query token can attend to the full visual sequence and the entire query context, enabling query-aware pruning without cloud-model access, autoregressive generation, or costly aggregation over multiple query positions. LAST then retains a diverse set of query-relevant visual tokens under a fixed token budget. We evaluate LAST on 11 multimodal benchmarks under multiple token budgets against pruning methods with different guidance strategies. Experiments show that LAST consistently achieves the strongest performance, preserving 95.4% of the full-token accuracy while retaining only 12.5% of the visual tokens, with low edge-side selection overhead and reduced cloud-side computation.

Graph foundation models (GFMs) have emerged as a promising paradigm for transferring knowledge across graph domains and tasks. Real-world graphs associate nodes with text, images, and other modalities, making multimodal graphs essential for representing complex entities and relations. Moreover, collecting labels and adapting models for every new graph domain is costly and often infeasible, motivating zero-shot transfer. Unfortunately, zero-shot transfer on multimodal graphs remains underexplored. Existing GNN-based graph foundation models typically require downstream adaptation, whereas LLM-based graph methods mainly address unimodal graphs or tasks within a single domain. This setting presents two key challenges. First, models must generalize knowledge from individual modalities while capturing transferable cross-modal relations. Second, without target-domain fine-tuning, node representations remain entangled with domain-specific structures and modality-specific characteristics, obscuring shared concepts in unseen domains. To address these challenges, we propose CHARM, a multimodal graph foundation model with hierarchical context modeling for zero-shot transfer. CHARM replaces isolated raw nodes with hierarchical graph contexts that capture multimodal semantics and cross-modal relations. These contexts map domain-specific node patterns to shared high-level concepts, reducing reliance on target-domain supervision or adaptation. A modality-aware graph context encoder integrates multimodal information with graph structure and converts the resulting representations into graph tokens for a large language model . Experiments show consistent improvements on zero-shot multimodal graph tasks.

Multimodal foundation models learned to see and to speak by consuming the whole internet. Embodied agents admit no such shortcut, since they require data that couple observations with physical states and actions. These signals can be provided, to varying degrees, by multiple data sources. In this work, we organize the embodied data ecosystem as a "pyramid" spanning five complementary sources: real-robot data, UMI-style data, egocentric and exocentric data, simulation data, and general vision-language data. We organize the pyramid around the tension between scalability and robot alignment, and further characterize each source in terms of data quality, diversity, reusability, and physical fidelity. We then analyze recent embodied foundation models through the lens of their data recipes, examining how different sources are selected, aligned, and mixed during pretraining. For embodied brain models, vision-language-action models, and world-action models alike, we relate data composition to capabilities in perception, reasoning, planning, action generation, and world prediction. We close by discussing six open challenges: building large-scale tactile datasets, collecting failure and recovery data, developing scalable data-collection pipelines, aligning actions across embodiments, leveraging egocentric data for dexterous manipulation, and designing principled data recipes for robot learning. We hope this work paves the foundation for the design of next-generation embodied systems.

The renewed global focus on lunar exploration, driven by the prospect of in-situ resource utilization and a sustained human presence on the Moon, has created growing demand for accurate, large-scale characterization of the lunar surface. Although vast quantities of orbital remote-sensing data have been collected, scientific analysis and resource mapping remain fragmented by heterogeneous multiinstrument observations, sparse labels, and bespoke task-specific modelling workflows. Here we introduce LunarFM, a multimodal foundation model that learns a general representation of the lunar surface from diverse orbital measurements. LunarFM assimilates observations from six instruments across three lunar missions, mapping 18 input channels to a shared embedding space. We demonstrate that this embedding space supports a diverse range of downstream applications, including similarity search, few-shot resource mapping, mineral abundance regression, and geological unit classification, enabling efficient scientific investigation and resource-oriented analysis. We provide a machine-learning-ready dataset of co-registered multimodal observations spanning latitudes from 70°S to 70°N, a pretrained multimodal masked autoencoder, and a companion embedding dataset providing a joint 768-dimensional representation of lunar surface properties. All code and data are available at https://lunarfm.trillium.tech/

Autoregressive foundation models trained on tokenized electronic health records (EHRs) can support zero-shot clinical prediction, yet most operate on structured event codes alone, and do not incorporate multiple modalities in a principled way. We present a framework for conditioning such models on auxiliary clinical modalities, including ECG waveforms, chest X-ray images, and clinical notes, using modality-specific latent compression and gated cross-attention with temporal alignment. We investigate two key design choices: (1) how to compress long per-modality sequences (e.g., ECG time series) before they enter the multi-modal cross-attention. This feature may be essential to reduce compute overheads and may be beneficial for generalization; (2) how the choice of pretrained encoder for each modality impacts downstream performance. Through controlled ablations on MIMIC-IV, we show that the best latent-compression configurations outperforms both uncompressed cross-attention and mean pooling. Encoder choice has a clear within-modality effect, with stronger pretrained encoders consistently outperforming weaker alternatives. We further show that merely adding auxiliary modalities does not guarantee improvement on ICU mortality prediction over an EHR-only baseline. This implies that careful design of the fusion architecture and an appropriate evaluation in the clinical context are required.

Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules. Although recent protein language models have enabled progress in single-chain protein modeling and generation, they often fall short in antigen-specific antibody design, where effective modeling requires explicit pairing between antibody and antigen, particularly at the epitope level. To address these limitations, we introduce AAMFM, an Antigen-specific Antibody Multimodal Foundation Model that learns unified representations of antibody sequences and structures conditioned on antigen context. AAMFM incorporates rich antigen information including geometric interfaces and epitope annotations via a cross-modal adapter, enabling joint modeling of antibody-antigen interactions in a shared latent space. To further guide the model toward functional relevance, we fine-tune AAMFM using Calibrated Direct Preference Optimization (Cal-DPO), leveraging preference signals extracted from a strong structural prior to align learning with binding-specific objectives. Extensive experiments demonstrate that AAMFM achieves state-of-the-art performance in functional antibody design, revealing its potential for antigen-specific antibody engineering. Our code is available at https://github.com/XL-S224/AAMFM.

Vision-Language Navigation (VLN) requires an embodied agent to interpret a natural-language instruction and predict actions from temporally ordered visual observations. Adapting a multimodal large language model to VLN requires visual-language alignment, compact temporal inputs, action-space grounding, and stable training on the target hardware. This technical report presents PGN (Pangu Navigator), an offline VLN action-prediction system built on OpenPangu-7B. Training proceeds in two stages. First, PGMM aligns a frozen EVA-ViT-G/14 vision encoder with the frozen language backbone by training a Q-Former and a two-layer MLP projector. Second, PGN adapts the aligned model to expert navigation trajectories using five-observation windows, epoch-dependent temporal sampling, and a reasoning-then-action output format; this stage freezes the aligned visual pathway and updates three structural-token embeddings and LoRA adapters. The implementation combines mixed-precision computation, selective FP32 computation, and DeepSpeed ZeRO-2 on eight Ascend 910B NPUs. Under teacher-forced, open-loop evaluation on 500 held-out expert trajectories, V9 reports a 62.29% Normalized Action Match (NAM) and a 100.00% Non-empty Rate (NER). These metrics quantify offline expert-action alignment rather than closed-loop navigation success; evaluating error accumulation, path efficiency, and goal completion remains future work.

Industrial time series serve as the foundation for Prognostics and Health Management (PHM) to ensure the reliability and safety of industrial equipment such as aero-engines. However, existing approaches are typically limited to single-modality modeling, which restricts their generalization in complex scenarios. Although recent advances in large language models (LLMs) provide new opportunities for multimodal learning, bridging continuous time-series signals and discrete textual semantics remains an open challenge. To this end, we propose VLT, a multimodal foundation model that jointly models time-series, frequency-spectrum visual representations, and textual knowledge. A key insight is to utilize the frequency spectrum as a visual bridge to connect continuous temporal signals with discrete semantics. Specifically, a Time-aware Mixture-of-Experts (Time-MoE) is designed to capture heterogeneous temporal dynamics, while a Frequency-Text Augmented Learner enables joint modeling of spectral and semantic features within a shared representation space. Furthermore, a time-centric gradient alignment mechanism is introduced to mitigate cross-modal optimization conflicts via gradient normalization and reliability-aware dynamic reweighting. Extensive experiments on multiple industrial datasets demonstrate that VLT outperforms state-of-the-art methods, achieving superior robustness and generalization under few-shot, noisy, and incomplete-modality settings.

Building foundation models for medical imaging requires pooling data across institutions, yet privacy regulations prohibit centralized aggregation. Existing Federated Foundation Models either fine-tune natural-image models with poor medical-domain transfer, or train from scratch within a single modality, lacking the flexibility to unify tasks. We identify an under-explored challenge, Imaging Modality Heterogeneity, where clients operate under two structural regimes: Overlapped (shared modalities with heterogeneous label distributions) and Non-overlapped (fully disjoint modalities per client). We propose FM$^2$, a unified framework that trains the core backbone from scratch to preserve medical domain fidelity while optionally incorporating biomedical pretrained encoders for vision-language alignment. FM$^2$ equips each client with dual Mixture-of-Experts modules (a Class-wise MoE for personalized category knowledge and a Domain-wise MoE for shared cross-modality representations), coupled with a Heterogeneous Modality Alignment (HMA) regularizer that explicitly aligns modality-specific expert parameters, admitting provable $O(1/\sqrt{T})$ convergence and generalization guarantees. FM$^2$ further incorporates Caption-Enhanced Learning (CEL), where locally retained GPT-4o-generated captions serve as a textual semantic bridge enabling representation transfer across clients with disjoint modalities, and demonstrates extensibility to Federated Medical VQA. Experiments on our MIMH benchmark (classification and CEL) and real-world medical VQA datasets confirm consistent superiority over state-of-the-art federated baselines and strong out-of-modality generalization across all three tasks.

Predictive modeling is a core component of modern financial services, where a wide range of tasks are traditionally addressed using separate models trained on manually engineered tabular features. This task-specific approach limits reuse and makes it difficult to fully exploit heterogeneous data sources such as transaction histories and digital interaction signals. In this paper, we present an approach based on pretraining a foundation transformer model on multimodal sequences of user events. Events from multiple data sources are unified into a single chronological sequence, enabling early fusion of heterogeneous modalities and learning of general-purpose representations via a next-event prediction objective. These representations are combined with existing engineered user features, on top of which lightweight neural models are trained for multiple downstream tasks. The proposed system outperforms traditional task-specific models while reducing development overhead. The approach was deployed in production at one of the biggest banks in Eastern Europe, resulting in measurable improvements in business metrics.

With the growing adoption of VLMs, DMs, LLMs, and AFMs, these multimodal foundation models can inadvertently encode sensitive, copyrighted, biased, or unsafe cross-modal associations that originate from their training data. Retraining after deletion requests or policy updates is often impractical, and targeted forgetting remains difficult because knowledge is distributed across shared representations. Multimodal unlearning addresses this challenge by enabling selective removal across modalities while retaining overall utility. This survey offers a unified, system-oriented view of multimodal unlearning across vision, language, audio, and video, grounded in recent advances, emerging applications, and open problems. Our taxonomy enables systematic comparison across model architectures and modalities, clarifying trade-offs among deletion strength, retention, efficiency, reversibility, and robustness. This survey highlights open problems and practical considerations to support future research and deployment of multimodal unlearning. We release a curated repository: https://smsnobin77.github.io/Awesome-Multimodal-Unlearning/

Medicine is inherently multimodal, requiring clinicians to synthesize information across diverse data streams. Yet the development of multimodal foundation models is constrained by limited access to large-scale, high-quality clinical data. Although PubMed Central (PMC) offers a complementary source of expert-authored image-text data, existing PMC-derived resources remain limited in fidelity, reproducibility, and clinical validation. We introduce MedPMC, an automated, continuously updatable framework that transforms permissively licensed literature into high-fidelity infrastructure for medical multimodal models. Applied to 6.1 million PMC articles, MedPMC curated 11 million medical image-text pairs. Component evaluations showed strong performance for initial screening (F1 = 93.2), multi-panel figure detection (F1 = 96.5), figure separation (mAP = 89.8), caption separation and alignment (F1 = 81.4; ROUGE-L = 85.3), and medical figure classification (F1 = 96.5). Manual review by five annotators, three with medical training, found 95.3% of MedPMC images medically relevant, versus 19.7% in a prior PMC-derived dataset. Across 26 benchmarks spanning 11 specialties, a MedPMC-trained CLIP-style model improved average zero-shot AUC by 7.1 percentage points over the strongest architecture-matched biomedical CLIP baseline despite using fewer than half as many image-text pairs. As the vision encoder in a multimodal large language model, it improved medical visual question-answering by 1.9 and 16.9 percentage points across two benchmarks. In 10,524 Yale New Haven Health System dermatology photographs, it improved morphology-to-image retrieval Recall@5 by 11.7 percentage points. These findings show that high-fidelity literature curation strengthens medical multimodal foundation models across benchmark and clinical settings. We publicly release the framework, corpus, benchmarks, and pretrained models.

Decades of orbital missions have produced multi-modal remote sensing data for the Moon, spanning optical imagery, spectroscopy, thermal emission, radar, gravity, and elemental composition. Yet these datasets remain fragmented across archives, and no benchmark exists for evaluating machine learning on lunar data. We introduce Moonstone, the first multi-modal foundation model benchmark for lunar remote sensing. Our contributions are: (1) a 28-channel, 128 pixels-per-degree (~237 m) global lunar pretraining dataset from seven instrument families across five missions, (2) MG-MAE, a modality-grouped masked autoencoder with per-group convolutional tokenizers, a shared Vision Transformer encoder, attention masking for missing modalities, coverage-adaptive masking for heterogeneous spatial coverage, and spectral continuity regularization for physically plausible reconstructions, and (3) a benchmark of six downstream tasks covering classification, regression, and segmentation. MG-MAE pretrained features outperform scratch baselines on all tasks and surpass both ImageNet-pretrained and vanilla MAE baselines by large margins. Data and code are available at https://huggingface.co/datasets/ayushprd/Moonstone and https://github.com/ayushprd/Moonstone .

Foundation models have recently emerged as a powerful paradigm for learning transferable representations from large scale biomedical data, yet existing approaches for physiological waveforms primarily optimize reconstruction or forecasting objectives that do not explicitly preserve clinically meaningful waveform morphology. Electrocardiograms (ECGs) and pulse oximetry (SpO2) waveforms encode rich cardiovascular and hemodynamic information through their morphological structure. In this work, we introduce MorphologyFM, a multimodal foundation model pretrained on paired ECG and SpO2 waveforms from the MIMIC critical care database using a morphology aware self supervised learning objective. MorphologyFM combines morphology guided masking, cross modal representation learning, and contrastive latent alignment to learn representations that capture clinically relevant physiological structure without requiring manual annotations. We evaluate MorphologyFM across multiple downstream prediction tasks, including arrhythmia classification, hypoxemia prediction, mortality prediction, and length of stay estimation, demonstrating consistent improvements over representative self supervised learning methods, including Masked Autoencoders (MAE), contrastive learning, Barlow Twins, and Joint Embedding Predictive Architectures (JEPA). Furthermore, we show that jointly modeling ECG and SpO2 waveforms produces more transferable representations than single modality pretraining. Our results establish waveform morphology as a powerful inductive bias for self supervised physiological representation learning and introduce MorphologyFM as a general purpose foundation model for continuous physiological monitoring.

Foundation models for Earth systems have so far been trained primarily on physical climate and weather data, with limited representation of the human systems that both drive and respond to environmental change. The lack of a unified global training resource that combines climate, land, ocean, cryosphere, infrastructure, hazards, and socioeconomic data on a common grid hinders progress toward truly multimodal Earth system foundation models. We present WorldTensor, a harmonised global dataset that aligns hundreds of environmental and socioeconomic variables to a standardised 0.25$^\circ$ spatial grid and annual temporal framework. WorldTensor integrates reanalysis products, remote sensing, emissions inventories, land use reconstructions, hydrological observations, infrastructure and hazard datasets, and socioeconomic indicators within a single representation designed for machine learning workflows. To build the dataset, we regridded inputs across heterogeneous native resolutions and projections, rasterised point and vector datasets into spatially meaningful gridded fields, and reconciled temporal coverages ranging from daily observations to sparse multiyear socioeconomic snapshots. All outputs are distributed as NetCDF files with standardised coordinates, variable metadata, and a common CF metadata convention. WorldTensor provides a reproducible resource for training and evaluating foundation models that learn coupled dynamics across environmental and human systems at planetary scale.

Recent advances in AI-driven weather and climate modeling have improved forecast skill while reducing computational cost. However, existing data-driven approaches are limited in their ability to model coupled Earth system dynamics, which is required for extending predictability beyond the ~2-week horizon. To address this, we introduce NIVA, a multimodal foundation model designed to learn unified representations across Earth system components. While the full framework targets atmosphere, ocean, ice, and land interactions, we focus here on a two-modality setting (ocean and atmosphere) as a controlled proof of concept to evaluate whether foundation models can learn coupled dynamics. Trained on large-scale Earth system simulations, NIVA learns physically meaningful cross-modal structure, providing a foundation for subseasonal-to-seasonal prediction. As initial validation, we show that NIVA captures key modes of climate variability through accurate prediction of major climate indices.

We present Wan-Streamer, a native-streaming, end-to-end interactive foundation model designed from the ground up for real-time, low-latency, full-duplex audio-visual interaction. Wan-Streamer seamlessly models language, audio, and video as both input and output within a single Transformer, where the sequence is represented as interleaved visual, audio, and text input tokens together with visual, audio, and text output tokens, coordinated by block-causal attention for incremental streaming. Unlike cascaded interactive systems that rely on separate VAD, ASR, language, TTS, audio-driven animation, or video-generation modules, Wan-Streamer does not rely on external language, speech, avatar, or video-generation modules: perception, reasoning, generation, response timing, turn management, and cross-modal synchronization are learned jointly within one unified model, reducing pipeline latency and error accumulation. To support natural audio-visual responsiveness, we redesign the entire stack around streamability, including causal encoders, causal decoders, block-causal attention, and low-latency multimodal token scheduling, enabling streaming units as short as 160 ms at 25 fps. Wan-Streamer achieves approximately 200 ms model-side response latency and approximately 550 ms total interaction latency when combined with 350 ms bidirectional network latency, supporting sub-second duplex audio-visual communication. These results position Wan-Streamer as a unified, end-to-end, multimodal interactive foundation model for low-latency streaming interaction.

General-purpose models often struggle to reliably identify and understand real-world multimodal risks, largely due to the inherent multimodal adversarial nature of content and AI safety. We present Yuvion VL, a family of multimodal large language models purpose-built for content and AI safety, with both instruction-tuned and reasoning-oriented variants. Yuvion VL addresses this gap by treating safety as an inherently adversarial and multimodal problem and designing the entire pipeline around adversarial robustness. For data construction, we develop an automated pipeline integrating adversarial-aware data synthesis with multi-stage quality control, producing large-scale, high-quality multimodal samples augmented with domain knowledge and reasoning annotations. For training, we adopt a three-stage pipeline that includes continued pretraining for risk-concept cross-modal alignment, instruct post-training for production-grade safety tasks, and reasoning post-training for enhanced interpretability and performance in complex tasks. We further introduce Confuse-then-Contrast Fine-Tuning, a contrastive framework that mines model-specific confusions and constructs multi-image contrastive groups to enforce explicit discrimination of fine-grained visual-semantic elements, enabling the model to distinguish between visually similar cases with different safety implications in adversarial safety tasks. To support rigorous evaluation, we further introduce Yuvion VL RiskEval (YVRE), a collection of benchmarks covering diverse open and internal evaluations, with a focus on content and AI safety, adversarial robustness, and real-world capability requirements. Experiments show that Yuvion VL-32B achieves industry-leading safety performance, surpassing comparably sized open-source models and best closed-source commercial models, while maintaining comparable general capabilities.

We present BioMatrix, the first multimodal foundation model that natively integrates sequences, structures, and natural language for both molecules and proteins within a single decoder-only architecture. Existing biological foundation models pursue native multimodality and broad entity coverage separately: those that fuse multiple modalities under a shared objective remain confined to a single entity type, while those spanning multiple entity types either omit explicit structural modeling or rely on adapter-based designs in which the model cannot natively generate the very modalities it can read. BioMatrix closes this gap by mapping molecular sequences (supporting both SMILES and SELFIES notations), molecular structures, protein sequences, protein structures, and natural language into a shared discrete token space through a unified tokenization scheme, so that all modalities are consumed and produced uniformly under a single next-token prediction objective -- without external encoders, projection adapters, or modality-specific output heads. Built upon the Qwen3 language model (1.7B and 4B), BioMatrix is continually pretrained on 304.4 billion tokens spanning general and domain-specific text, sequence and structure views of molecules and proteins, and cross-modal corpora that interleave biomolecular entities with scientific text and link distinct entities through molecule-protein and protein-protein interaction data. After tuning on a comprehensive suite of downstream applications covering 80 tasks across 6 categories -- encompassing single-entity and multi-entity understanding and generation tasks across and within modalities -- BioMatrix achieves state-of-the-art or competitive performance on 77 out of 80 tasks, demonstrating that a single, natively multimodal generalist model can effectively match or surpass specialized approaches across a wide range of biological tasks.

Deploying multimodal foundation models as closed-loop policies increasingly requires conditioning actions on observations that are no longer visible. However, existing benchmarks either expose the full state, conflate hidden-state reconstruction with other agent skills, or test recall only after an episode has ended. We introduce RNG-Bench (Reconstructive Non-Markov Games), a benchmark suite designed to isolate a base model's ability to reconstruct past observations and act on them during multi-step interaction. RNG-Bench includes two complementary games: Matching Pairs, where card identities briefly revealed at specific locations must later be recalled, and 3D Maze, where egocentric views must be integrated into a spatial map. Both games are evaluated under a unified harness with three controlled difficulty axes: grid size, visual pattern, and observation modality. The benchmark further introduces a head-to-head duel protocol to control for instance-level variance and a Memory Gap metric that disentangles forgetting from poor action selection. The hardest configurations require contexts of roughly 128K tokens and 350 image inputs per episode, and remain far from saturated by frontier MLLMs. Memory Gap analysis shows that most residual errors stem from forgetting earlier observations rather than from suboptimal decision making. Finally, fine-tuning Qwen3.5-9B on optimal-policy rollouts and filtered model demonstrations improves performance on RNG-Bench and transfers to existing benchmarks without degrading general multimodal capability.

Multimodal Foundation Models are increasingly used as reasoning agents, making reliability, knowing when a model may hallucinate, critical. A common intuition, which we call the Attention-Confidence Assumption, holds that reliability follows from "structural" visual perception: tight attention on relevant regions should signal a trustworthy answer, while scattered attention signals confusion. We challenge this through the VLM Reliability Probe (VRP), a systematic cross-family study of reliability signals in contemporary Vision-Language Models (VLMs). We introduce structural-attention metrics, cluster counts (C_k) and spatial entropy (H_s), to quantify the visual encoder's gaze, and track its evolution (Delta H_s) across layers. This reveals a "Symbolic Detachment": models often "Early Lock" visual features only to diffuse attention later, severing early perception from final generation. Contrary to the grounding hypothesis, we find a "Cluster Failure": spatial attention has near-zero correlation (R approx 0.001) with accuracy. Instead, reliability is a phenomenon of generation dynamics and internal-state distributions. Self-Consistency, the agreement rate across sampled reasoning paths, is the dominant predictor of truth (R = 0.429). Scaling causal interventions exposes a sharp architectural divergence: LLaVA locks its prediction in a fragile late-stage bottleneck, whereas PaliGemma and Qwen2-VL distribute reliability globally, staying resilient even when ~50% or more of their most predictive layer is destroyed. For current VLMs, reliability signals are detached from visual grounding maps and are best inferred from generation-time dynamics and hidden-state probes.

Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored. This work systematically evaluates FM-based representations on a suite of computational pathology tasks across two real-world commercial cohorts, IH-BC and IH-NSCLC, drawn from the licensed in-house (IH) oncology dataset. The analysis focuses on two modalities, whole-slide images and transcriptomic profiles, drawn from the IH multimodal data. We first benchmark unimodal probing performance across five FMs on eight downstream classification tasks, and find that image and omics representations carry complementary predictive signals. Then we investigate whether multimodal fusion can yield additional gains over unimodal baselines by comparing three image-omics fusion strategies built on paired representations. The trustworthiness of selected unimodal and multimodal pipelines is further assessed through conformal prediction. Our results show that FM representations achieve competitive performance on out-of-distribution data and that multimodal fusion helps mainly when no single modality dominates the signal. Conformal prediction reveals that in the majority of cases where a point prediction fails, the true diagnosis remains recoverable within the prediction set, reinforcing the value of uncertainty-aware inference for clinical support.

Granger Causal Discovery (GCD) is fundamental for analyzing temporal dependencies in complex systems. However, existing neural GCD methods predominantly rely on a "one-size-fits-all" paradigm, struggling to capture distribution shifts and dynamic regime changes inherent in real-world time series. This often leads to entangled representations and spurious causal graphs. In this paper, we propose CausalMoE, a billion-scale multimodal Granger causal foundation model that explicitly models patch-level heterogeneity. CausalMoE introduces a Pattern-Routed Mixture of Heterogeneous Experts, which dynamically identifies latent temporal patterns and routes patches to specialized domain experts, effectively decoupling regime-specific mechanisms from shared dynamics. To ensure interpretable graph recovery, we design a Causality-Aware Self-Attention mechanism operating across variables, yielding sparse Granger causal graphs via proximal optimization. Furthermore, CausalMoE is the first to integrate LLMs and VLMs to align numerical signals with textual and visual priors, regularizing causal estimation in complex scenarios. Extensive experiments demonstrate that CausalMoE establishes a new state-of-the-art on fully supervised benchmarks, while effectively generalizing to few-shot settings where traditional methods fail.

Foundation models are rapidly transforming Earth observation by enabling scalable pretraining across diverse unlabeled geospatial modalities. However, their architectural diversity ranging from encoder-only to encoder-decoder and masked autoencoding paradigms makes it challenging to assess performance trade offs in a consistent manner. In this work, we present an apples-to-apples comparison of leading FM architectures designed for geospatial multimodal reasoning, with a particular focus on flexibility across varied spectral band configurations. We standardize pretraining using identical self supervised learning objectives and training datasets, and evaluate all models under consistent parameterization on the GEOBench benchmark across classification and segmentation tasks. Our results offer new insights into the design trade-offs between model flexibility, modality alignment, and downstream task performance. By highlighting architectural strengths and limitations under controlled conditions, this study provides practical guidance for building next generation geospatial foundation models capable of robust multimodal reasoning.

Deep learning models facilitate the discovery of molecules with tailored properties among billions of candidate compounds. However, the computational burden to develop and deploy state-of-the-art models continuously increases, limiting their scalability. Most large-scale models are unimodal in nature and overlook the potential to leverage complementary molecular data modalities. To address these shortcomings, this paper introduces the Graph-Language Alignment for Chemical Inference and Exploration using Representations (GLACIER) model, a student-teacher framework that integrates molecular graphs, SMILES strings, and physicochemical descriptors to learn rich molecular embeddings. Our framework consists of three stages: (1) we pretrain three student encoders on 100,000 drug-like molecules: a message-passing neural network for molecular graphs, a transformer-based encoder for SMILES strings, and a multilayer perceptron for physicochemical descriptors, (2) we fuse these student modalities using a novel Finsler geometry-aware module, and (3) distill complementary knowledge from large teacher models, including MiniMol and MolFormer, into a single lightweight model via contrastive learning. We demonstrate that GLACIER is a robust framework that delivers high predictive performance and computational efficiency in complex molecular property prediction tasks. Our code is publicly available at https://github.com/eemokey/glacier.

We introduce Kwai Keye-VL-2.0-30B-A3B, an open-source Mixture-of-Experts (MoE) multimodal foundation model designed to advance long-video understanding and agentic intelligence. To address the challenges of ultra-long contexts, information redundancy, and prohibitive computational costs inherent in hour-level videos, Keye-VL-2.0 is the first to adapt DeepSeek Sparse Attention (DSA) to GQA-based multimodal architectures, enabling lossless 256K context processing while capturing critical frames and long-range temporal dependencies. This architecture is underpinned by a highly optimized training and inference infrastructure, including scalable video I/O, heterogeneous ViT-LM parallelism, and custom DSA kernels that significantly maximize throughput and minimize computational overhead. Furthermore, to overcome the algorithmic dilemma of catastrophic forgetting during multi-task alignment, we introduce Cross-Modal Multi-Teacher On-Policy Distillation (MOPD) paired with Context-RL and Video-RL. By distilling dense token-level teacher feedback from on-policy rollouts back into the MoE backbone, which activates only 3B parameters, Keye-VL-2.0 natively empowers advanced agent collaboration across Code, Tool, and Search scenarios with multimodal self-correction. Extensive evaluations across video understanding, temporal grounding, reasoning, STEM, and agent benchmarks demonstrate that Keye-VL-2.0-30B-A3B achieves state-of-the-art performance among models of similar scale, particularly excelling in fine-grained temporal localization on TimeLens and long-video comprehension on Video-MME-v2 and LongVideoBench. We release our model checkpoints to accelerate community progress toward scalable and robust multimodal agentic applications.

Respiratory diseases remain a leading cause of global mortality, where timely and accurate diagnosis is critical to improving patient outcomes and reducing healthcare burdens. While prior work has explored audio-based models for respiratory disease detection, such unimodal approaches often suffer from limited generalizability and diagnostic precision. In this paper, we propose RespiraMFM, a Multimodal Foundation Model that integrates respiratory sounds with patient medical history and symptoms to enhance diagnostic accuracy and disease detection capabilities. We introduce an effective contrastive alignment strategy for audio-text multimodal integration, allowing the model to learn better cross-modal representations between respiratory sounds and corresponding textual clinical information. We evaluate RespiraMFM across five major respiratory diseases using seven real-world datasets in both supervised fine-tuning and zero-shot settings, achieving a 9.15% improvement in AUROC on supervised tasks and a 20.98% gain on zero-shot tasks over existing baselines. These findings underscore the potential of our framework to advance early diagnosis and improve clinical decision-making in respiratory disease management.

Foundation models offer a promising route to compress multi-modal physiological signals into compact representations of human health, with broad applications across sleep medicine, cardiology, neurology and other healthcare domains. Existing models have typically been trained with masked-reconstruction or contrastive objectives. However, masked reconstruction may be poorly suited to the stochastic nature of these signals, while contrastive approaches rely on positive-pair definitions despite the semantic invariances of physiological signals being poorly understood. In this work, we show that next-token prediction is a simple and scalable alternative. We develop Hypnos, a multi-modal sleep foundation model trained using eight different sensing modalities (e.g. EEG, ECG, respiratory signals) drawn from over 20,000 overnight polysomnography recordings. We tokenize each modality into streams of discrete tokens using residual vector quantization, then train a large auto-regressive RQ-Transformer to jointly predict the next token across all modalities in parallel. After training, Hypnos can be applied to continuous streams of sensor data from any subset of supported modalities, generating embeddings for downstream tasks. Across a range of benchmarks, Hypnos significantly outperforms existing foundation models. In sleep stage classification, we match the performance of strong supervised baselines on held-out test sets whilst using $100\times$ less labelled data. Hypnos even generalises to daytime physiology, surpassing a dedicated ECG foundation model at detecting atrial fibrillation. Our results demonstrate that next-token prediction is a strong self-supervised objective for representation learning from multi-modal physiological signals.

Multimodal Foundation Models (MFMs) have made substantial progress, yet remain fragile in spatial reasoning over the physical world. A key bottleneck lies in their inability to transform local egocentric observations into a global allocentric spatial representation. To address this, we propose AlloSpatial, an agentic framework for allocentric spatial cognition in foundation models. AlloSpatial introduces World2Mind, a plug-and-play cognitive mapping sandbox that converts egocentric observations into structured allocentric priors, including Allocentric-Spatial Trees and route maps that support querying object topology, geometric relations, passability, and trajectories. To utilize these priors reliably under noisy reconstruction and ambiguous visual evidence, AlloSpatial introduces a Spatial Reasoning Harness for tool-use judgment, modality-decoupled cue collection, and geometry-semantic arbitration. We further internalize this process in Qwen3-VL through cold-start reinforcement learning with a harness-gated trajectory-level reward. Experiments on VSI-Bench and MindCube show that AlloSpatial improves proprietary models by 5%-18% in a training-free setting, while ASTs alone support strong spatial reasoning even when visual inputs are removed. The trained AlloSpatial agents further outperform larger general-purpose models and competitive spatial baselines, suggesting that structured allocentric representations, active tool use, and verifiable reasoning offer a promising route toward spatially capable foundation models.

Test-time Scaling (TTS) has emerged as a pivotal research direction for enhancing model performance by dynamically allocating computational resources during inference. Recent advancements have adapted this paradigm to Multimodal Foundation Models (MFMs), unlocking their potential in multimodal reasoning and generation. Despite rapid progress, the field lacks a systematic survey and unified theoretical framework to delineate the developmental landscape of multimodal TTS. To bridge this gap, we present the first comprehensive review of TTS research for MFMs, proposing a unified taxonomic framework that categorizes existing methodologies into three distinct strategies: sampling-based, feedback-based, and search-based approaches. We further summarize representative applications and benchmarks commonly utilized to evaluate multimodal TTS capabilities in generation and reasoning tasks. Finally, this survey discusses open challenges and outlines future research directions, providing a systematic roadmap for subsequent studies in this rapidly evolving field.

Time series foundation models (TS-FMs) aim to learn generalizable temporal representations that can be adapted to a wide range of downstream tasks. In real-world multimodal settings, time series are frequently affected by temporal misalignment and partial modality missingness, where different modalities are observed at heterogeneous time scales or are partially absent. Existing approaches typically rely on naive imputation or masking strategies, which fail to account for cross-modal dependencies and often lead to misaligned or degraded representations. We propose TRACE, a conditional estimation paradigm for multimodal time series foundation model pipelines under missingness and irregular sampling, allowing incomplete target modalities to be systematically inferred from available auxiliary modalities. We evaluate TRACE on diverse multimodal benchmarks spanning healthcare and affective computing, including the MIMIC-IV clinical dataset and the CMU-MOSI and CMU-MOSEI benchmarks for multimodal sentiment analysis. Across a range of downstream prediction tasks and missing-modality settings, TRACE consistently outperforms prior multimodal fusion approaches, demonstrating improved robustness to severe modality missingness and more reliable cross-modal representations.

Efficient multimodal foundation models often rely on manually designed token-reduction operators, such as pruning, merging, pooling, and adaptive reweighting. Although these operators appear different, we show that they can be interpreted as distinct regimes of a shared operator space. Based on this view, we introduce Efficient Operator Search, a differentiable framework that jointly searches where to reduce tokens, how many tokens to retain, and how reduced token information should be processed. The proposed search space parameterizes layer activation, retention budget, and operator behavior, while the search policy optimizes task performance under one-sided budget and cost constraints. This formulation recovers representative hand-designed baselines as special cases and further discovers hybrid operators beyond isolated manual designs. Experiments on multimodal benchmarks show that the searched operators achieve competitive accuracy-efficiency trade-offs, especially under aggressive visual-token reduction. These results suggest that efficient multimodal inference can be reframed from manual operator design to differentiable operator search.

Real-world image restoration (IR) is bottlenecked by the scarcity of high-quality paired training data. Synthetic datasets are abundant but often fail to model real-world degradations, while real-world paired datasets are expensive and difficult to capture. As a result, IR models trained on these datasets show limited generalization in real-world scenarios. In this work, we propose Generative Ground Truth (GGT) by using generative multimodal foundation models (MFMs) to produce high-quality (HQ) targets from real-world low-quality (LQ) images. We first conduct a systematic evaluation of nine state-of-the-art MFMs, including Nano-Banana-2 and GPT-Image-2, on images of various scenes and degradation types. The results demonstrate that Nano-Banana-2 with VLM-based adaptive prompting shows the highest capability to synthesize perceptually realistic and content-faithful HQ targets, which can serve as the GGT for the LQ input. We then employ Nano-Banana-2 to build a GGT synthesis pipeline, which involves multi-stage quality control to ensure data reliability, and construct GGT-100K, an LQ-HQ paired dataset comprising 103,707 training pairs and covering diverse scenes and complex real-world degradations. A test set of 500 image pairs is also established. Extensive experiments show that GGT-100K consistently improves the real-world generalization of a wide range of IR models, with particularly strong benefits for finetuning generative models for IR tasks. Our results suggest that MFMs can serve as practical tools for restoration-oriented data generation, and GGT-100K is a useful resource to expand the generalization boundaries of real-world IR models.

Reinforcement learning (RL) has shown promise in traffic signal control (TSC). However, its reliance on predefined states limits responsiveness to observable open-world events that are absent from training data. IoT-enabled intersections provide heterogeneous observations from roadside sensors and cameras, creating opportunities to improve RL adaptability to such events. To this end, we propose ReasonLight, a multimodal foundation model-enhanced RL framework for zero-shot TSC. ReasonLight integrates three sources of information: structured traffic measurements, multi-view camera observations, and candidate phase decisions from a pre-trained RL controller. Given an RL-proposed phase, ReasonLight extracts visual semantics from multi-view images and aligns them with compact sensor-derived scene descriptions. This alignment enables a semantic-guided refinement module to either preserve or adjust the proposed action according to traffic rules and event semantics. To ensure operational reliability, refined actions are constrained by the set of available phases. Any invalid decision is rejected, and the system falls back to the original RL action. We evaluate ReasonLight on two types of rare events not seen during RL training: emergency vehicle priority and temporary traffic regulation. Experimental results show that ReasonLight achieves zero-shot adaptation without retraining. It reduces emergency vehicle waiting time by up to 88.7% compared with the RL-only backbone while preserving comparable routine traffic performance.

Foundation models offer a promising route to transferable remote sensing representations, but many current approaches depend on very large pretraining datasets and fixed sensor configurations, limiting their suitability for ecological and environmental applications, where observations often vary across platforms, spatial and spectral resolutions, and available modalities. We introduce FLORO, a multimodal geospatial foundation model designed to learn transferable representations from a small but highly diverse remote sensing corpus. FLORO is pretrained using masked autoencoding on a heterogeneous combination of Sentinel-1, Sentinel-2, SkySAT imagery, elevation, and UAV-derived data. To accommodate sensor variability, FLORO incorporates availability-aware inputs that indicate which spectral bands and auxiliary modalities are present in each sample, enabling a unified input space across heterogeneous sensor configurations. We evaluated FLORO on the PANGAEA benchmark under a frozen-encoder protocol across scene classification, segmentation, and regression tasks. Despite being pretrained on a smaller corpus than competing foundation models, FLORO achieved strong and stable transfer across optical, optical-SAR, and optical-elevation benchmarks spanning medium-resolution satellite, airborne, and ultra-high-resolution UAV imagery. FLORO obtained the second-best average segmentation performance across six PANGAEA benchmarks, trailing only a recently introduced foundation model pretrained on over two orders of magnitude more images, remained competitive on scene classification, and was robust in regression tasks, while qualitative results showed improved preservation of spatial structure in flood, urban, biomass, and canopy-height prediction settings. In a separate controlled experiment on EuroSAT-MS, geo-positional encoding further improved classification relative to absolute positional encoding.

Time series foundation models (TSFMs) are transforming the forecasting paradigm through large-scale cross-domain pretraining. However, most existing TSFMs remain univariate, and recent efforts to enable cross-variate modeling still operate directly within the raw variate space. This design introduces fundamental limitations in semantic alignment and relational expressivity. Specifically, raw-space group mixing lacks a dedicated mechanism to align heterogeneous physical quantities, while standard non-negative attention fails to capture the complex synergistic and antagonistic interactions ubiquitous in real-world systems. To address these challenges, we propose Falcon-X, decouples variates from the raw space and maps them into a unified latent prototype space. Falcon-X employs a Unified Prototype Diff-Attention mechanism that explicitly evaluates both positive and negative semantic affinities to explicitly align heterogeneous variates. Cross-variate interactions are then efficiently performed within this shared space via Latent Entity Attention, naturally facilitating zero-shot structural transfer. Finally, a Variate Reassembly Router robustly reconstructs variate-specific trajectories via a request-and-dispatch mechanism. Extensive evaluations on the GIFT-Eval and fev-bench benchmarks demonstrate that Falcon-X achieves excellent forecasting performance, offering a principled and scalable paradigm for complex multivariate environments. Falcon-X is publicly released to support future research.

Polymer discovery is central to fields ranging from energy storage to biomedicine, but it is hindered by an astronomically large chemical design space and fragmented representations of structure, properties, and prior knowledge. This fragmentation leaves many AI models disconnected from physical and experimental reality, restricting their ability to support directly actionable design decisions. Here we introduce PolyFusionAgent, an interactive framework coupling a multimodal polymer foundation model (PolyFusion) with a tool-augmented, literature-grounded design agent (PolyAgent). PolyFusion aligns complementary polymer views including sequence, topology, 3D geometry, and fingerprints across millions of polymers to learn a shared latent space transferable across chemistries and data regimes, improving thermophysical property prediction and enabling property-conditioned generation of chemically valid, structurally novel polymers beyond the reference design space. PolyAgent closes the design loop by linking prediction and inverse design with evidence retrieval from the polymer literature, proposing, evaluating, and contextualizing hypotheses with explicit precedent in one workflow. Together, PolyFusionAgent enables interactive, evidence-linked polymer discovery combining large-scale representation learning, multimodal chemical knowledge, and verifiable scientific reasoning.

Real-world time series come with text: metadata, descriptions, news, reports. Yet time series foundation models process numerical sequences in isolation, and the multimodal text-and-time-series models that attempt to bridge the two all adapt a pretrained language model post hoc, inheriting representations shaped without ever seeing temporal data. These models are also evaluated almost exclusively against other multimodal baselines, not against the strongest unimodal foundation models in either domain, leaving open whether joint training is needed at all. We present Chronicle, a compact 324M-parameter decoder-only transformer trained from scratch on natural language and time series within a single unified architecture. Both modalities share the same transformer blocks, attention mechanism, and residual stream; the bulk of pretraining uses unimodal batches so cross-modal capability emerges purely from shared parameters, with a short alignment stage that interleaves the two. To our knowledge, Chronicle is the first model jointly pretrained on text and time series from scratch, and the first multimodal model evaluated against dedicated foundation models in both domains. It matches Gemma-3-270M-PT on 19 NLU tasks, sets a new bar for frozen-embedding time series classification on 24 UCR/UEA datasets, and produces multimodal forecasts on Time-MMD that beat every supervised fusion baseline, all from a single backbone.

While vision and multimodal foundation models underpin critical tasks from perception to complex reasoning, they remain highly vulnerable to adversarial attacks. However, traditional adversarial attacks are typically limited to single, predefined objectives, tightly coupling each attack to a specific model or task, which restricts their scalability and flexibility in real-world scenarios. In this work, we present DarkLLM, a novel attack framework that trains an LLM to translate natural-language attack instructions into latent attack vectors, which are then decoded into visual adversarial perturbations. By leveraging natural-language instruction tuning, DarkLLM not only unifies targeted, untargeted, segmentation, and multi-model attacks within a single framework, but also achieves flexible and controllable adversarial generation, enabling each instruction to produce a perturbation that induces desired behaviors across heterogeneous models. Through extensive experiments across 4 tasks, 13 datasets, and 15 models, we demonstrate that DarkLLM with only 1B parameters can follow attacker instructions and generate highly effective attacks against CLIP, SAM, and frontier LLMs, revealing a systemic vulnerability in modern foundation models.

Despite the recent success of Multimodal Foundation Models (FMs), their reliance on massive paired datasets limits their applicability in low-data and rare-scenario settings where aligned data is scarce and expensive. A key bottleneck is the adoption of an instance-level formulation, which learns alignment by maximizing correlation between individual image-text pairs while neglecting the underlying geometric structure across modalities resulting in a modality gap across input modalities. In this paper, we propose a combinatorial paradigm for multimodal alignment that moves beyond pairwise learning and introduce the \emph{Submodular Modality Aligner (SMA)}, which treats multiple augmentations and descriptions of an entity as a set, leveraging multiple descriptions of the data to capture richer cross-modal structure. We instantiate SMA using a principled objective based on Submodular Mutual Information (SMI), which jointly maximizes inter-modality mutual information while reducing cross-modal divergence. This formulation enables the model to effectively utilize multiple positive associations and extract significantly more information from limited data. We evaluate SMA on 14 zero-shot classification and retrieval tasks from the CLIP benchmark and demonstrate consistent gains in the low-data regime. Notably, SMA achieves strong multimodal generalization using only tens of thousands of samples. This is orders of magnitude fewer than standard approaches. Our results highlight the importance of set-based formulations and submodular objectives for data-efficient multimodal learning.

Large foundation models (FMs) are transforming Earth science by integrating heterogeneous multimodal data, such as multi-platform imagery, gridded reanalysis data, diverse geophysical and geochemical observations, and domain-specific text, to support tasks ranging from basic perception to advanced scientific discovery. This paper provides a unified review of Earth science foundation models (Earth FMs) through two complementary dimensions: depth, which traces the evolution of model capabilities from perception to multimodal reasoning and agentic scientific workflows, and breadth, which summarizes their expanding applications across the atmosphere, hydrosphere, lithosphere, biosphere, anthroposphere, and cryosphere, as well as coupled Earth system processes. Using this framework, we review representative multimodal Earth foundation models and compile more than 200 datasets and benchmarks spanning diverse Earth science tasks and modalities. We further discuss key challenges in multimodal data heterogeneity, scientific reliability and continual updating, scalability and sustainability, and the transition from foundation models to agentic and embodied Earth intelligence, and outline future directions toward more integrated, trustworthy, and actionable AI Earth scientists. Overall, this paper offers a structured roadmap for understanding the development of Earth foundation models from both capability depth and application breadth.

Forecasting future 3D hand pose sequences from egocentric video is essential for understanding human intention and enabling embodied applications such as AR/VR assistance and human-robot interaction. However, this task remains a highly challenging problem because egocentric hand motion is driven by complex human intent, exhibits highly dexterous articulations, and is observed under drastic viewpoint shifts induced by ego-motion. In this work, we introduce EggHand, a foundation-model-based framework for egocentric hand pose forecasting that unifies multimodal semantic reasoning with dynamic motion modeling. Our approach couples an action decoder from a Vision-Language-Action (VLA) model, which captures the structured temporal dynamics of hand motion, with an egocentric video-text encoder that provides viewpoint-aware contextual information learned from large-scale first-person video. Together, these components overcome the brittleness of generic visual encoders under ego-motion and enable joint reasoning over motion, context, and high-level intent-without relying on body pose or external tracking. Experiments on the EgoExo4D dataset show that EggHand sets a new state of the art in forecasting accuracy, remains robust under severe ego-motion, and further enables controllable prediction via language-based task prompts. Project page: https://jyoun9.github.io/EggHand

Health foundation models (FMs) learn useful representations from wearable sensors, but interpreting what they encode and transferring that knowledge across modalities after training remains difficult. We present a post-training framework that decomposes frozen embeddings into interpretable directions, referred to as symbols, and use these symbols to align the embedding spaces without retraining. We evaluate the framework on three FMs for photoplethysmography (PPG) and accelerometer data, independently pretrained on ~20M minutes of unlabeled data from ~172K participants, and analyzed on a held-out cohort of 30K subjects. We find that extracted symbols associate selectively with health conditions and physiological attributes, and these associations are partially shared across modalities and architectures. Cross-modal transfer via symbols retains more than 95% of in-domain performance, is nearly symmetric across domain directions, and saturates with limited paired data, together indicating that alignment recovers a shared low-dimensional subspace rich in physiological information. Overall, these results suggest that health FM embeddings contain an interpretable symbolic organization that is shared across modalities and supports cross-domain transfer without joint training.

Cognitive neuroscience is fragmented into specialized models, each tailored to specific experimental paradigms, hence preventing a unified model of cognition in the human brain. Here, we introduce TRIBE v2, a tri-modal (video, audio and language) foundation model capable of predicting human brain activity in a variety of naturalistic and experimental conditions. Leveraging a unified dataset of over 1,000 hours of fMRI across 720 subjects, we demonstrate that our model accurately predicts high-resolution brain responses for novel stimuli, tasks and subjects, superseding traditional linear encoding models, delivering several-fold improvements in accuracy. Critically, TRIBE v2 enables in silico experimentation: tested on seminal visual and neuro-linguistic paradigms, it recovers a variety of results established by decades of empirical research. Finally, by extracting interpretable latent features, TRIBE v2 reveals the fine-grained topography of multisensory integration. These results establish artificial intelligence as a unifying framework for exploring the functional organization of the human brain.

Audio-Visual Intelligence (AVI) has emerged as a central frontier in artificial intelligence, bridging auditory and visual modalities to enable machines that can perceive, generate, and interact in the multimodal real world. In the era of large foundation models, joint modeling of audio and vision has become increasingly crucial, i.e., not only for understanding but also for controllable generation and reasoning across dynamic, temporally grounded signals. Recent advances, such as Meta MovieGen and Google Veo-3, highlight the growing industrial and academic focus on unified audio-vision architectures that learn from massive multimodal data. However, despite rapid progress, the literature remains fragmented, spanning diverse tasks, inconsistent taxonomies, and heterogeneous evaluation practices that impede systematic comparison and knowledge integration. This survey provides the first comprehensive review of AVI through the lens of large foundation models. We establish a unified taxonomy covering the broad landscape of AVI tasks, ranging from understanding (e.g., speech recognition, sound localization) to generation (e.g., audio-driven video synthesis, video-to-audio) and interaction (e.g., dialogue, embodied, or agentic interfaces). We synthesize methodological foundations, including modality tokenization, cross-modal fusion, autoregressive and diffusion-based generation, large-scale pretraining, instruction alignment, and preference optimization. Furthermore, we curate representative datasets, benchmarks, and evaluation metrics, offering a structured comparison across task families and identifying open challenges in synchronization, spatial reasoning, controllability, and safety. By consolidating this rapidly expanding field into a coherent framework, this survey aims to serve as a foundational reference for future research on large-scale AVI.

Using multimodal foundation models to analyze table images is a high-value yet challenging application in consumer and enterprise scenarios. Despite its importance, current evaluations rely largely on structured-text tables or clean rendered images, leaving the visual complexity of in-the-wild table images underexplored. Such images feature varied layouts and diverse domains that demand sophisticated structural perception and numerical reasoning. To bridge this gap, we introduce WildTableBench, the first question-answering benchmark for naturally occurring table images from real-world settings. WildTableBench comprises 402 high-information-density table images collected from online forums and websites across diverse domains, together with 928 manually annotated and verified questions spanning 17 subtypes across five categories. We evaluate 21 frontier proprietary and open-source multimodal foundation models on this benchmark. Only one model exceeds 50% accuracy, while all remaining models range from 4.1% to 49.9%. We further conduct diagnostic analyses to characterize model failures and reveal persistent weaknesses in structural perception and reasoning. These results and analyses provide useful insights into current model capabilities and establish WildTableBench as a valuable diagnostic benchmark for table image understanding. Dataset: https://huggingface.co/datasets/jzhuang/WildTableBench Code: https://github.com/hjzhe/WildTableBench Leaderboard: https://hjzhe.github.io/WildTableBench

Integrating multimodal foundation models into enterprise ecosystems presents a fundamental software architecture challenge. Architects must balance competing quality attributes: the high latency and non-determinism of vision language action (VLA) models versus the strict determinism and real-time performance required by enterprise control loops. In this study, we propose an architectural pattern language for visual agents that separates fast, deterministic reflexes from slow, probabilistic supervision. It consists of four architectural design patterns: (1) Hybrid Affordance Integration, (2) Adaptive Visual Anchoring, (3) Visual Hierarchy Synthesis, and (4) Semantic Scene Graph.

Recent advances in large-scale visual representation learning have significantly improved performance in plant species and plant disease recognition tasks. However, state-of-the-art models, often based on high-capacity vision transformers or multimodal foundation models, remain computationally expensive and difficult to deploy in resource-constrained environments such as mobile or edge devices. This limitation hinders the scalability of automated biodiversity monitoring and precision agriculture systems, where efficiency is as critical as accuracy. In this work, we investigate knowledge distillation as an effective approach to transfer the representational capacity of large pretrained models into smaller, more efficient architectures. We focus on plant species and disease recognition, and conduct an extensive empirical study on two challenging benchmarks: Pl@ntNet300K-v2 and Deep-Plant-Disease. We evaluate four representative architectures, including two ConvNeXt models and two vision transformers, under multiple training regimes: from-scratch training and pretrained initialization, each with and without distillation. In total, we train and evaluate 70 models. Our results show that knowledge distillation consistently improves performance across tasks and architectures. Distilled models are able to match the performance of significantly larger models while maintaining substantially lower computational cost. These findings demonstrate the potential of knowledge distillation techniques to enable efficient and scalable deployment of plant recognition systems in real-world environmental applications.

Biological function emerges from coupled constraints across sequence, structure, regulation, evolution, and cellular context, yet most foundation models in biology are trained within one modality or for a fixed forward task. We present MIMIC, a generative multimodal foundation model trained on our newly curated and aligned dataset, LORE, linking nucleic acid, protein, evolutionary, structural, regulatory, and semantic/contextual modalities within partially observed biomolecular states. MIMIC uses a split-track encoder-decoder architecture to condition on arbitrary subsets of observed modalities and reconstruct or generate missing components of molecular state across the genome, transcriptome, and proteome. Multimodal conditioning consistently improves MIMIC's sequence reconstruction relative to sequence-only inputs, while its learned representations enable state-of-the-art performance on RNA and protein downstream tasks. MIMIC achieves state-of-the-art splicing prediction, and its joint generative formulation enables isoform-aware inference that further improves performance. Beyond prediction, the same generative framework supports constrained design. For RNA, MIMIC identifies corrective edits in a clinically relevant HBB splice-disrupting mutation without reverting it by using evolutionary and structural signals. For proteins, jointly conditioning on shape and surface chemistry of PD-L1 and hACE2 binding sites produces diverse, high-confidence sequences with strong in silico support for target binding. Finally, MIMIC uses experimental context as semantic conditioning to model assay-dependent RNA chemical probing, rather than treating context as a fixed output. Together, these results position MIMIC's aligned multimodal generative modeling as a strong foundation for unifying representation learning, conditional prediction, and constrained biomolecular design within a single model.

In recent years, the integration of multimodal machine learning in wellbeing assessment has offered transformative potential for monitoring mental health. However, with the rapid advancement of Vision-Language Models (VLMs), their deployment in clinical settings has raised concerns due to their lack of transparency and potential for bias. While previous research has explored the intersection of fairness and Explainable AI (XAI), its application to VLMs for wellbeing assessment and depression prediction remains under-explored. This work investigates VLM performance across laboratory (AFAR-BSFT) and naturalistic (E-DAIC) datasets, focusing on diagnostic reliability and demographic fairness. Performance varied substantially across environments and architectures; Phi3.5-Vision achieved 80.4% accuracy on E-DAIC, while Qwen2-VL struggled at 33.9%. Additionally, both models demonstrated a tendency to over-predict depression on AFAR-BSFT. Although bias existed across both architectures, Qwen2-VL showed higher gender disparities, while Phi-3.5-Vision exhibited more racial bias. Our XAI intervention framework yielded mixed results; fairness prompting achieved perfect equal opportunity for Qwen2-VL at a severe accuracy cost on E-DAIC. On AFAR-BSFT, explainability-based interventions improved procedural consistency but did not guarantee outcome fairness, sometimes amplifying racial bias. These results highlight a persistent gap between procedural transparency and equitable outcomes. We analyse these findings and consolidate concrete recommendations for addressing them, emphasising that future fairness interventions must jointly optimise predictive accuracy, demographic parity, and cross-domain generalisation.

Recent medical multimodal foundation models are built as multimodal LLMs (MLLMs) by connecting a CLIP-pretrained vision encoder to an LLM using LLaVA-style finetuning. This two-stage, decoupled approach introduces a projection layer that can distort visual features. This is especially concerning in medical imaging where subtle cues are essential for accurate diagnoses. In contrast, early-fusion generative approaches such as Chameleon eliminate the projection bottleneck by processing image and text tokens within a single unified sequence, enabling joint representation learning that leverages the inductive priors of language models. We present CheXmix, a unified early-fusion generative model trained on a large corpus of chest X-rays paired with radiology reports. We expand on Chameleon's autoregressive framework by introducing a two-stage multimodal generative pretraining strategy that combines the representational strengths of masked autoencoders with MLLMs. The resulting models are highly flexible, supporting both discriminative and generative tasks at both coarse and fine-grained scales. Our approach outperforms well-established generative models across all masking ratios by 6.0% and surpasses CheXagent by 8.6% on AUROC at high image masking ratios on the CheXpert classification task. We further inpaint images over 51.0% better than text-only generative models and outperform CheXagent by 45% on the GREEN metric for radiology report generation. These results demonstrate that CheXmix captures fine-grained information across a broad spectrum of chest X-ray tasks. Our code is at: https://github.com/StanfordMIMI/CheXmix.

This work presents a multi-layered methodology for efficiently accelerating multimodal foundation models (MFMs). It combines hardware and software co-design of transformer blocks with an optimization pipeline that reduces computational and memory requirements. During model development, it employs performance enhancements through fine-tuning for domain-specific adaptation. Our methodology further incorporates hardware and software techniques for optimizing MFMs. Specifically, it employs MFM compression using hierarchy-aware mixed-precision quantization and structural pruning for transformer blocks and MLP channels. It also optimizes operations through speculative decoding, model cascading that routes queries through a small-to-large cascade and uses lightweight self-tests to determine when to escalate to larger models, as well as co-optimization of sequence length, visual resolution & stride, and graph-level operator fusion. To efficiently execute the model, the processing dataflow is optimized based on the underlying hardware architecture together with memory-efficient attention to meet on-chip bandwidth and latency budgets. To support this, a specialized hardware accelerator for the transformer workloads is employed, which can be developed through expert design or an LLM-aided design approach. We demonstrate the effectiveness of the proposed methodology on medical-MFMs and on code generation tasks, and conclude with extensions toward energy-efficient spiking-MFMs.

Modern medicine generates vast multimodal data across siloed systems, yet no existing model integrates the full breadth and temporal depth of the clinical record into a unified patient representation. We introduce Apollo, a multimodal temporal foundation model trained and evaluated on over three decades of longitudinal hospital records from a major US hospital system, composed of 25 billion records from 7.2 million patients, representing 28 distinct medical modalities and 12 major medical specialties. Apollo learns a unified representation space integrating over 100 thousand unique medical events in our clinical vocabulary as well as images and clinical text. This "atlas of medical concepts" forms a computational substrate for modeling entire patient care journeys comprised of sequences of structured and unstructured events, which are compressed by Apollo into virtual patient representations. To assess the potential of these whole-patient representations, we created 322 prognosis and retrieval tasks from a held-out test set of 1.4 million patients. We demonstrate the generalized clinical forecasting potential of Apollo embeddings, including predicting new disease onset risk up to five years in advance (95 tasks), disease progression (78 tasks), treatment response (59 tasks), risk of treatment-related adverse events (17 tasks), and hospital operations endpoints (12 tasks). Using feature attribution techniques, we show that model predictions align with clinically-interpretable multimodal biomarkers. We evaluate semantic similarity search on 61 retrieval tasks, and moreover demonstrate the potential of Apollo as a multimodal medical search engine using text and image queries. Together, these modeling capabilities establish the foundation for computable medicine, where the full context of patient care becomes accessible to computational reasoning.