Agent-Based Model

Extracting informative representations from longitudinal data that can predict future outcomes remains a critical challenge in medicine. Medical datasets are inherently heterogeneous, consisting of a large number of variables collected from different sources, sampled with different temporal spacings, and representing different aspects of human health status. This requires identifying those variables with predictive value, processing longitudinal information, and integrating multiple variables for outcome prediction. Here, we propose a novel agent-based approach, LongAgent, that can autonomously search over combinations of variable sets, temporal windows and longitudinal aggregation functions, and identify candidates with promising predictive performance. LongAgent utilises a history memory of previous searches and numerical evidence to guide subsequent exploration. On synthetic data, LongAgent achieves a mean prediction RMSE of 1.7376 and improves over the strongest non-agent baseline by 0.0151 (95% CI: [0.0045,0.0260]; p=0.0273). On a real clinical dataset, it performs comparably to the best baseline.

Limit order book (LOB) simulators are most useful to practitioners when they combine realistic market dynamics, computationally efficient sampling, controllable scenario generation, and the ability to generalize beyond the instruments seen during training---properties that existing agent-based and deep generative simulators provide only partially. We present \textbf{FlowLOB}, a conditional \textbf{flow}-matching generator of \textbf{LOB} trajectories, trained on multiple Hong Kong Exchange (HKEX) symbols at three sampling frequencies ($0.1$s, $1$s, $10$s) in tick-relative representation that transfers to unseen instruments. Because flow and diffusion models admit a common formulation, we train both with identical data, architecture, and budget, and sample both through the same fixed-step ODE solvers, yielding a controlled comparison of sampling efficiency and fidelity. Flow matching attains its best quality with only $10$ ODE-solver steps, whereas diffusion needs many more function evaluations to approach the same fidelity. At this efficient operating point, FlowLOB improves realism over baselines, two learned and two agent-based models, in most distributional metrics at the two finer sampling frequencies. We evaluate counterfactual controllability with a distributional test that asks whether changing a scenario condition moves the generated statistic toward the corresponding real tail regime; FlowLOB satisfies this criterion in most tested settings. Both realism and control effects transfer zero-shot on a held-out symbol. We additionally conduct ablation studies on the network architecture and the learning rate.

Tipping-point dynamics describe the critical conditions under which a committed minority drives a population to abandon an established convention in favor of a new one. We present a transparent agent-based model of this process, in which agents hold one of two behavioral states and a mobile committed minority attempts to overturn the incumbent convention. Our goal was to examine how localized mobility, bounded agent memory, and network topology jointly influence the tipping threshold. Using a custom agent-based simulation framework, we found that in many configurations, tipping becomes effectively inevitable: given sufficient time, the population always converges to the minority state. This observation motivated a complementary analysis focused on the pace of convergence rather than its feasibility. We introduce a unified predictive model that accurately estimates how structural and behavioral parameters determine the time required for complete adoption, showing that mobility is the dominant accelerator while memory and connectivity modulate convergence in systematic ways. Together, these results extend classical tipping-point research by linking structural and behavioral factors not only to the likelihood of convention change but also to the timescale on which it unfolds. While we frame the model in terms of convention-like binary behavioral adoption, the same mechanisms bear on norm change and other contagion-like social processes.

Agent-based models (ABMs) are difficult to reproduce: their behavior is spread across prose narratives, platform-specific code, and implicit assumptions, so that two readers routinely reconstruct different models from the same documentation. We present VISA, a structured, symbol-based description protocol that specifies a model in eight interconnected tables---four at the agent level (Agent, Variable, Sensing, Internal Function) and four at the model level (Associated Data, Input/Output, Schedule, Validation)---under the principle of minimality with completeness. VISA makes a model machine-parseable and unambiguous via two artifacts: nineteen executable consistency rules that turn model validity into a checkable property, and three reusable LLM-executable skills (authoring, checking, and code generation) that operationalize the full author--check--code--reproduce loop. We validate the protocol on three external, independently authored ABMs spanning three platforms: we reproduce two cross-language (NetLogo to Python) directly from their VISA specifications, and we capture a third, an industrial AnyLogic model, in eight tables (passing all nineteen rules) while honestly demarcating where reproduction is blocked by a proprietary movement library and unavailable data---itself a transparency contribution. VISA moves the reproduction barrier from the model, where it is invisible, to a named, localized dependency, where it is actionable.

The rapid development of large language models (LLMs) has renewed interest in agent-based modeling (ABM). However, current LLM-based ABM research faces several key challenges: modeling evolving agent-environment interactions, enabling flexible counterfactual reasoning, and automating simulation workflows for scientific research. In this paper, we propose Eco3S, a socio-economic system simulation framework for economic research and policy analysis that addresses these challenges through three key mechanisms: (1) Co-evolving Environment Design, a bidirectional feedback loop where agents and the environment co-evolve, producing realistic emergent behaviors; (2) Structural Causal Simulation, a structural causal model (SCM)-inspired counterfactual mechanism that allows flexible interventions for diverse causal inference tasks; (3) Simulation-Analysis-Refinement Paradigm, a self-corrective mechanism that iteratively refines experimental designs based on prior simulation results. Experiments on diverse economic scenarios confirm \textit{Eco3S}'s effectiveness in replicating multiple established economic studies (canal decay, origins of governance, and information propagation) and phenomena across domains. Additional results further demonstrate its scalability and generalizability, highlighting the framework's potential for rigorous economic research and policy-making.

Communication allows large language model agents to pool evidence, but it also creates paths along which an erroneous claim can spread. We formulate a correction-aware network model that tracks susceptible, exposed, infectious, and corrected agents and derive its early-invasion condition for heterogeneous communication networks. We then couple this propagation model to an analytic majority-vote benchmark in which a clean-task reliability target imposes a minimum connectivity requirement. Under fixed exposure per communication edge, reliability and error control impose opposing graph constraints. We characterize when their intersection is empty and when it contains an intermediate connectivity range, and identify regular graphs that attain the smallest invasion factor within the reliable graph class when such graphs exist. Under a fixed sender budget, the homogeneous first-order threshold is independent of network density, showing that the communication-budget convention determines whether added edges increase early propagation risk. Finite-network simulations on 21,000 trajectories illustrate these directional predictions. A controlled grok-4.3 experiment then evaluates three six-node topologies on 36 new closed-world tasks, with a balanced 12-task subset continued to full cascades. Mean first-generation offspring increased from 0.667 to 1.333 and 1.667 as degree increased from 2 to 4 and 5, while the adoption fraction among exposed neighbours remained 0.333. Mean non-seed erroneous adoption in the full-cascade subset was 0.200, 0.333, and 0.333. Together, these results provide a tractable basis for selecting connectivity under explicit reliability and propagation constraints.

Agent-based models (ABMs) rely on simple, explicit and reproducible rules for individual decision making, while complex collective behavior emerges from interactions among agents. Recent advances in large language models (LLMs) make it tempting to replace, enrich, or perturb these rules with LLM-based agentic capabilities. However, this raises a methodological question: how does introducing LLM-driven decisions affect the reliability, computational cost, and behavior of ABM simulations? We investigate this for Mesa ABM models, a popular Python library for ABMs, analyzed by statistical model checking. Building on Mesa's integration with the statistical model checker MultiVeStA, we extend the classical Schelling segregation model with a hybrid population: ordinary agents classify neighbors using the standard symbolic rule, while one agent delegates this task to an LLM through tool calls. The LLM-enabled agent receives natural-language descriptions of neighboring agents and invokes tools that increment counters of similar/different neighbors; these counters determine its happiness according to the original Schelling dynamics. This provides a minimal but controlled setting where the semantic, operational, and computational behavior of LLM-based decisions can be studied inside an otherwise standard ABM. We report preliminary experiments with locally served LLMs of different sizes, showing that smaller models may fail simple semantic classification experiments or become operationally unusable during repeated tool-call generation, while larger tested models pass these preliminary checks. We discuss how statistical model checking can estimate classical ABM observables and quantify the impact of introducing agentic LLM components into simulation models.

This work addresses the need for engineering-grounded evaluation of implement-ed tariff mechanisms in distribution-level energy systems. A digital twin-based method is proposed for assessing local collective tariffs under realistic behavioral and infrastructural conditions. The approach integrates agent-based modeling of household consumption and generation, virtual aggregation through a shared metering abstraction, and explicit representation of tariff logic within a unified simulation environment. The method is demonstrated through its application to the Danish Local Collective Tariff across representative residential energy community configurations, including scenarios with photovoltaic generation, battery storage, and electric vehicle charging. Results indicate that aggregation of heterogeneous demand profiles reduces peak coincidence and enables more efficient allocation of tariff components, leading to measurable cost reductions at the community level. At the same time, the outcomes reveal sensitivity to the temporal alignment of consumption and generation, influencing the degree of cost neutrality across participants. The findings illustrate how digital twin-based evaluation can support systematic assessment of tariff mechanisms by capturing the interaction between infrastructure, user behavior, and regulatory design. The proposed approach provides a basis for analyzing and comparing tariff structures in distribution-level energy systems beyond the specific case considered.

This book chapter covers the evolution of social simulation from classical agent-based models, in which agents interact according to explicitly defined behavioral rules, to AI-enhanced simulations based on Large Language Models and, ultimately, Social Digital Twins: high-fidelity, data-driven representations of real-world socio-technical systems. Along this trajectory, we discuss the main methodological foundations, applications, advantages, and limitations of each paradigm, highlighting the progressive shift from abstract models designed to investigate general social mechanisms toward increasingly realistic computational representations of specific social systems.

Recently, Large Language Models (LLMs) have been utilized in various applications of computational social science and provide the possibility to integrate such models into agent-based modeling to explore the cognitive processes. However, how specific cognitive modules drive individual decisions and macro-level opinion dynamics remains unclear. Therefore, this study introduces a framework that integrates an LLM (Qwen3-8B) into agent-based modeling to investigate this problem, using vaccination opinion dynamics as a case study. We utilize this framework to simulate opinion dynamics among agents with heterogeneous profiles and social networks, evaluating scenarios by enabling different cognitive modules: a memory module and a prompt diversity module. The simulation results reveal that different cognitive modules have opposite impacts on our emergent opinion. Furthermore, the framework reproduces the non-linear behavior patterns of social influence observed in existing research, demonstrating our framework's validity and potential to reach the level 3 validation of agent-based models.

Agent-based modeling (ABM) has the capability to model millions of individuals and their interactions, which is useful for policy making. However, ABMs have traditionally relied on static prior, which prevents the models from adapting to real-time changes. Our research provides a novel approach to addressing this information gap. Large language models (LLMs) offer new opportunities to predict human decision-making. Here, we introduce a scalable Hybrid Agent-based and Language-driven Epidemic (HALE) modeling framework that leverages LLMs to predict human decision-making in an ABM simulation. As a proof-of-concept, we use HALE to simulate COVID-19 and its effects in Salt Lake County, UT.

LLM-agent simulations make natural-language social scenarios easy to instantiate, but their outputs can be overread as predictions and are often difficult to compare with explicit social dynamics. We present AgoraSim, a hybrid agent-based modeling framework for scenario-oriented social reaction analysis. AgoraSim resolves textual or multimodal artifacts into editable ABM configurations, runs ratio-controlled populations that mix LLM, vision-language, custom-endpoint, random, and classical agents, and compares the same scenario against matched classical reference dynamics. All agents emit a shared structured decision object, enabling common action spaces, interaction protocols, metrics, and audit records. Exposed through a local UI, Python SDK/CLI, and REST API, AgoraSim helps users inspect scenario trajectories, compare modeling assumptions, and identify cases that warrant empirical validation.

Mechanistic modeling via ordinary differential equations (ODEs) provides interpretable descriptions of complex dynamics and enables inference of underlying mechanisms, which is particularly valuable in clinical settings. However, in rare diseases, both the structure and parameters of the model are typically unknown, while individual-level data is scarce, noisy, heterogeneous, and subject to privacy constraints. In such settings, population-level summary statistics provide a practical privacy-preserving data representation, while capturing heterogeneity further requires modeling parameters as distributions rather than fixed values. Yet no existing method jointly discovers ODE structure and refines parameter distributions solely from summary statistics. We present AgentODE, an end-to-end framework that addresses this gap. An LLM proposes candidate ODE structures, while a tool-augmented inference agent iteratively refines parameter distributions through a diagnosis--update loop, operating on population-level summary statistics alone. We evaluate AgentODE on three benchmark problems across different fields and two clinical datasets, including the rare disease recessive dystrophic epidermolysis bullosa (RDEB), with only 231 observations across 46 patients. AgentODE recovers functionally consistent ODE structures across all settings, and experiments on RDEB demonstrates that in sparse and noisy data settings reasoning from summary statistics promotes mechanistically principled structure discovery, whereas baselines with individual-level data access recover implausible structures despite better predictive performance. AgentODE opens new possibilities for mechanistic modeling of rare diseases directly from population-level summary statistics, where data scarcity and privacy constraints have traditionally limited such analyses.

Climate governance processes involve complex interactions between heterogeneous citizens, advocacy groups, media actors, and political decision-makers. While agent-based models (ABMs) have been widely used to study environmental policy and socio-ecological systems, many existing approaches focus either on institutional dynamics or individual behavioural mechanisms in isolation. This paper presents a modular multi-level agent-based architecture that integrates empirically grounded cognitive decision models with strategic institutional behaviour within a unified simulation framework. The architecture combines (i) motive-based individual decision-making operationalised through the HUMAT and MOA frameworks, (ii) socially embedded influence processes via demographic homophily networks, and (iii) institutional strategy modules for environmental non-governmental organisations (NGOs), media agents, and politicians. Political decisions emerge from the aggregation of multiple signals, including expert input, public mobilisation, party alignment, and media framing. The model is designed to be empirically calibrated through synthetic populations derived from survey data and and institutional parameters informed through Living Lab stakeholder engagement, and to support scenario-based exploration of climate-relevant land-use governance processes. Rather than presenting empirical results, this paper focuses on the architectural design principles, modular structure, and integration logic of the model. We discuss how this multi-layered approach contributes to the modelling of democratic climate governance and outline pathways for generalization and future validation.

Characterizing the scenario underlying an epidemic from its disease cascade is an important task in simulation analytics. We propose boundary degree, the count of an infected node's contacts in the underlying contact network that were not infected, as a per-node cascade feature for this task. Through systematic ablation on realistic social contact networks of Tennessee and Virginia, we show that boundary degree alone improves scenario identification accuracy by 19%. Edge features, whose importance was observed empirically by prior work, consistently improve accuracy across all settings; we provide theoretical grounding for this observation. These effects are complementary. We prove that certain epidemic scenarios are indistinguishable without boundary or edge information. Prior feature engineering approaches included aggregate boundary statistics, but these were not among the top-ranked feature groups; the per-node representation we propose reveals their importance clearly. Our results suggest that contact tracing applications should track contacts with non-infected individuals, not only transmissions.

Metric aggregation divergence (MAD) is the silent inconsistency that arises when distinct pipeline stages in an agent-based model coupled with a multi-objective evolutionary algorithm (ABM+MOEA) independently re-implement how an outcome metric is extracted from simulation trajectories. Unlike deliberate analytical choices, MAD operates at the level of pipeline architecture: each stage is internally coherent, and the inconsistency becomes visible only when cross-stage outputs are compared. Code inspection of EpidemiOptim, a JAIR-published epidemic policy toolbox, reveals three structurally independent aggregation paths in peer-reviewed code. A faithful replication of this structure produces champion disagreement in 64.2% of independent runs (n=500, 95% CI: [59.9%, 68.3%]). In a 300-seed policy-flip experiment, divergent aggregation causes the optimizer to recommend the wrong champion in 83% of replications, with a mean welfare gap of 2.19 units and a Gini inequality gap of 0.050 units. In a follow-up inference audit, 3 of 249 flipped seeds cross the significance boundary itself. A complementary enterprise follow-up produces the predicted null under near-commensurable rankings (rho = 0.991), while a public upstream rerun of the Lake Problem DPS workflow shows that the archived published-path recommendation reaches joint-threshold success 0.401 whereas a shared contract-path rule reaches 0.552. We introduce the metric contract - a single shared callable enforced at dispatch time across all pipeline stages - as the remedy. Framed as standard engineering discipline applied to the cross-stage metric interface, the contract eliminates divergence by construction with approximately 3% runtime overhead.

Traditional economic modeling typically follows a TOP-DOWN paradigm, neglecting individual diversity and the complexity of social interactions. To better capture the complexity of societal structure, Agent-Based Modeling (ABM) employs a BOTTOM-UP solution by incorporating micro-level dynamics to generate macroeconomic phenomena. Reinforcement Learning further improves its decision-making ability through tailored reward signals. However, existing ABM systems struggle to generalize beyond predefined scenarios. Recognizing the potential of LLM-driven role-playing in perception and human-like decision-making, we propose SAMAS, which models individual agents with rich macroeconomic understanding embedded in LLMs and economic trajectories experienced in the passing simulation steps. By jointly modeling both macro-level structural patterns and micro-level dynamic behaviors, SAMAS achieves superior performance in volatility realism and turning point prediction.

Policy-oriented agent-based models are increasingly used to study regulatory interventions in complex adaptive socio-technical systems. Recent adaptive ABM frameworks distinguish between static and adaptive agents, fixed and adaptive policies, and alternative controller designs. However, most diagnostic workflows remain ex post: trajectories are analysed after simulation, but the resulting evidence is not systematically fed back into the policy controller. This paper proposes a lightweight machine-coached policy-revision layer for adaptive agent-based regulation. The layer represents policy decisions as defeasible rules with explicit conflicts and priorities, generates explanations for controller actions, and allows diagnostic failures to be translated into rule additions, removals, or priority changes. The contribution is not a new optimal controller and does not claim formal guarantees for unrestricted machine coaching. Instead, it provides a simulation-compatible operationalization of controller-level contestability: policy decisions can be explained, challenged, revised, and re-evaluated in held-out simulation runs. A stylized emissions-regulation ABM is used as the experimental component. A controlled simulation experiment focuses on an over-conservatism failure in the VPVA regime. The predefined coaching template adds a relaxation rule to the symbolic controller, reducing over-conservatism recurrence under held-out seeds while preserving violation, overshoot, and volatility guardrails. The paper argues that machine coaching is best understood as a controller-level extension of explainable adaptive ABM, complementary to causal, information-theoretic, and trajectory-based diagnostics.

Agent-based models are widely used to evaluate policy interventions in complex socio-technical systems, yet many policy-oriented ABMs represent regulation as a fixed scenario parameter. This limits their ability to distinguish whether regulatory conclusions depend on agent adaptation, policy adaptation, or the interaction between both. Building on a previously proposed four-regime architecture, this paper contributes a controlled simulation benchmark rather than a new general framework. Using a single configurable emissions-regulation ABM, we compare constant policy/constant agents, constant policy/adaptive agents, adaptive policy/constant agents, and adaptive policy/adaptive agents under matched simulation conditions. We evaluate naive fixed policies, tracking-aware calibrated fixed policies, and three adaptive controllers: setpoint, safety-margin, and one-sided control. The benchmark recovers expected controller archetypes: setpoint control tracks the cap but produces frequent boundary crossings, safety-margin control reduces violations through conservatism, and one-sided control can limit violations but may ratchet toward over-conservatism when combined with adaptive agents. The contribution is methodological: scalar indicators, cap-relative symbolic diagnostics, trajectory motifs, and visual inspection jointly reveal how regulatory conclusions can differ even when average outcomes appear similar. Adaptive policy-oriented ABMs should therefore be evaluated through regime distinguishability, not only through average performance.

A content-moderation system can score well on every standard accuracy metric and still cause real harm, if its mistakes fall on the few users who connect otherwise separate communities. We show this in an agent-based model where N=240 learning agents on a community-structured network each post harmless, productive, or dangerous content, and a regulator removes or penalizes whatever a noisy classifier flags. Overall usefulness barely moves as the noise changes (one-way ANOVA, p=0.96): by aggregate measures, nothing looks wrong. The damage instead concentrates on these bridge users, whose useful posts are wrongly suppressed and whose dangerous posts are wrongly spared. A governance loss (L_gov) that prices these two mistakes separately from the cost of enforcement more than doubles under false-positive-heavy noise. Aggregate accuracy hides who is harmed, and the cheap quantity to audit is how many connections a user has (degree), a near-perfect proxy for the betweenness that defines a bridge (r=0.96).

Statistical Physics has traditionally dealt with entities that interact merely based on the present, and possibly past, configurations. This reactive framework is inefficient in many situations involving living beings, such as predators chasing a prey, pedestrians, or even robots. This paper introduces a statistical physical framework for the dynamics of anticipatory agents, whose present-time dynamics depend on the prospective system state that they anticipate. We clarify how these dynamics can be expressed in terms of a cost function constructed based on observations and we show that the dynamics of an anticipatory agent in d dimensions can be mapped onto the dynamics of a (non-anticipatory) chain in d + 1 dimensions, with fluctuations acting transversely on the chain to account for the uncertainty about the future state. Insights from polymer Physics help us characterize the dynamics of these chains and delineate an anticipation horizon beyond which the blurry future can be handled in a mean-field way. The foregoing framework is successfully applied to pedestrian dynamics, leading to a seamless integration of operational and tactical levels in an agent-based model. Even with a minimal expression of the cost, the model succeeds in reproducing various experimental scenarios which are challenging for state-of-the-art models, such as crossing cluttered environments or alighting from a crowded train. The transparent and flexible basis of the model allows the straightforward incorporation of additional mechanisms.

Recent growth in compute power has made it increasingly feasible to use large-scale agent-based models to simulate complex adaptive systems. A central difficulty is that such models contain many local rules and parameters, where small changes can lead to runaway behaviour, population collapse, or saturation at artificial bounds. We study this problem in a continuous predator-prey system where sheep and wolves are active agents with local sensing, internal energy, and recurrent neural network-based controllers. We ask whether environmental and demographic parameters can be tuned so that the resulting population dynamics resemble classical Lotka-Volterra cycles. We optimise these parameters with a feature-based loss that rewards sustained oscillations, phase lag, bounded populations, and long-term persistence, first for random controllers and then for evolved controllers in a more naturalistic setting. The model is implemented in ABMax, a JAX-based agent-based modelling framework that enables efficient batched simulation on hardware accelerators.

Agent-Based Modelling (ABM) relies on clear documentation to ensure credibility and transparency. Although standards exist for documenting models (e.g. ODD), processes (e.g. TRACE, EABSS), and data use (e.g. RAT-RS), their adoption remains limited due to the effort required to produce documentation that is often treated as supplementary. This paper explores the use of Large Language Models (LLMs) to facilitate and partially automate such processes. We conduct a feasibility study focusing on the underused Rigour and Transparency Reporting Standard (RAT-RS), using four LLMs to extract reports from a published ABM paper. We assess consistency and performance across question types, finding that LLMs generate coherent outputs and perform more reliably on descriptive than on explanatory or evaluative tasks. While LLMs can improve reporting quality and consistency, they also exhibit notable limitations. We identify practical heuristics for when LLM-assisted documentation is reliable and when human oversight is needed and call for systematic community-level exploration to enhance rigour and adoption in ABM reporting.

Why is the past of English "go" the apparently unrelated "went"? Such alternations are frequent in languages. They neither aid communication nor learnability, yet they can be persistent, surviving over centuries or millennia. We present a multi-agent simulation of the emergence of morphological stem and inflection alternations. Alternate forms arise by phonological changes or, as with "go/went", from lexical alternatives associated with a subset of the population. When an agent 'hears' another agent use a novel form for a slot in the paradigm of a word (say, the past tense of go), they will with some probability adopt that form, possibly spreading its use to other slots in the paradigm that shared the same original form. Thus alternative forms can spread through the population and become entrenched as stem or inflectional marker alternants. Unlike many previous computational studies, our system allows for naturalistic lexical forms, realistic phonological rules, lexicons with hundreds or thousands of entries, and agent populations in the tens or hundreds. It supports several network topologies, diffusion patterns and agent adoption policies. One issue with such simulations is evaluation: how realistic is the resulting morphology compared to those of real languages? We introduce the AI Historical Linguist, a novel Large Language Model-driven system that models a debate between two historical linguists. We use this to compare a set of real language morphologies, disguised morphologies, and experimentally evolved morphologies. The results suggest that among the factors that favor more plausible morphologies are scale-free social networks and random Bernoulli adoption of forms. We also present three case studies modeling attested historical changes, allowing us to test what might have happened if history had been different. All code and data are released.

Telehealth, the delivery of medical care remotely, is hoped to increase access to specialty services or decrease health care utilization. Physicians can provide telehealth to each other or to patients. Specialists often treat complex patients who can be adequately cared for only in academic hospitals, suggesting that providing specialty services via telehealth will reallocate rather than reduce system utilization. Here I use agent-based modeling to investigate telehealth's effects on clinical outcomes and system utilization in medical toxicology. I found that physician-physician telehealth increased patient health but system utilization did not change. The effects were more pronounced as clinical complexity increased. Physician-patient telehealth increased cost and system utilization but not clinical outcomes. Within the limitations of our approach, these results suggest that telehealth is more cost-effective for improving generalist access to specialist knowledge than in providing care to the public.

Modelling individual decision-making during infectious disease outbreaks is crucial for understanding behavioural dynamics and informing effective public health interventions. Prior work has shown that large language models can simulate realistic human behaviour by generating agent decisions based on demographic prompts and situational context. We build on this foundation with a spatially grounded, agent-based simulation framework that integrates LLM-generated decisions about self-reported influenza-like illness into a census-based synthetic population of agents. Location is treated as a central feature: agents are assigned to spatial units within cities, capturing the spatial distributions of different demographic groups using real-world census data and enabling geographically diverse behavioural modelling. We implement and compare three decision scenarios, independent reasoning, household influence, and message framing, and simulate self-reporting outcomes in San Francisco and Atlanta. Results reveal that income and education are the dominant drivers of reporting rate variation, with smaller but consistent effects from geography, LLM model choice, and message framing. Our framework generates synthetic data that captures both social and geographic heterogeneity, supporting spatial epidemiological modelling and bias-aware behavioural analysis.

Purpose The WHO's COVID-19 non-pharmaceutical interventions (e.g., lockdowns, vaccinations) effectively curb transmission but impose heavy economic strains. Existing research often neglects individual behaviors and falsely assumes perfect infection tracking and flawless policy execution, failing to account for real-world uncertainties and errors. Methods We propose an integrative approach incorporating uncertainties in both epidemic measurement (infections/hospitalizations) and policy implementation. We built a simulation model of 1,000 individuals making real-time choices regarding mask-wearing, vaccination, and shopping. Concurrently, policymakers deploy interventions (lockdowns, mandates) based on health and economic observations. This framework is driven by hierarchical reinforcement learning agents, utilizing deep Q-networks alongside uncertainty-aware policy gradient variants (DDPG and TD3). Results The simulations effectively managed the epidemic's progression. Masking and vaccinations proved highly effective, significantly reducing both the outbreak's peak height and duration. By integrating individual behaviors, policy uncertainties, and multifaceted interventions, our dynamic control approach successfully mitigated the epidemic's impact. Conclusions Our model overcomes previous research limitations by embedding uncertainty and human behavior into public health policy frameworks. The simulation demonstrates that accounting for individual choices and imperfect data is crucial for designing effective interventions during complex pandemics, with masks and vaccines serving as pivotal tools.

Human behaviour during epidemics affects infectious disease dynamics, but quantifying this remains deeply challenging. Here we introduce the Epi-LLM framework: a novel integration of agent-based modelling, real-life epigames, and large language models (LLMs) in which a synthetic society of agents reasons and adapts dynamically over an outbreak contact network. Comparing synthetic agent behaviour against a no-intervention SEIR baseline and human participant data from the AUIB epigame study, we find that LLM agents across four different architectures reduced peak active infections, with quarantine compliance peaking at 58-65% on day six of the 15-day simulation. A binomial generalised linear model showed that perceived health severity was the strongest predictor of quarantine behaviour ($β= 0.33, p = 0.002$), yielding a pseudo-$R^2$ of 0.055, comparable to the 0.072 observed in the human trial. LLM architecture is a key determinant of epidemic dynamics: low-variance architectures offer greater internal validity for testing behavioural rules, while high-variance models may better represent real-world decision-making. Geographic labels alone do not induce culturally differentiated behaviour; explicit attitudinal parameterisation is required. This proof-of-principle work lays the groundwork for deploying the Epi-LLM framework as a scalable, risk-free simulation environment for pandemic preparedness research.

This paper introduces the Multi-Activity Transport & Mobility (MATraM) Agent-Based Model (ABM), a novel framework designed to advance activity-based transport modelling by incorporating dynamic activity adaptation. Traditional transport models simulate system performance using varying levels of abstraction, including flow-based, queue-based, and interaction-based mobility representations. While these approaches differ in their treatment of movement and congestion, they typically rely on pre-defined trip patterns that limit responsiveness to changing conditions. In particular, conventional activity-based models generate trips from fixed daily schedules, constraining their ability to capture behavioural flexibility and uncertainty. MATraM addresses this limitation by enabling agents to flag activities modification requests in response to sub-optimal travel conditions, such as increased travel times. By coupling with an activity scheduling and modification framework, the model integrates adaptive decision-making into the generation and execution of daily activity schedules. This allows for a more realistic representation of how individuals adjust their behaviour in response to transport system dynamics, leading to emergent mobility and congestion patterns. The ABM is presented following the ODD protocol, outlining its purpose, structure, and implementation. MATraM includes detailed representations of agents, their activity schedules, and the transport network, alongside submodels governing routing, scheduling, and behavioural adaptation. By bridging activity-based modelling with interaction-based mobility simulation, MATraM provides a flexible and extensible platform for exploring transport dynamics under uncertainty. This work contributes to the development of next-generation transport models capable of capturing the complex interplay between individual behaviour and system-level outcomes.

Modern information systems require autonomous agents capable of navigating complex workflows, yet current methodologies often struggle with the transition from structured metadata parsing to general environmental perception. While the integration of MLLMs has enabled agents to interact directly with GUIs, existing approaches typically treat task sequences as discrete, linear episodes. This fragmentation prevents agents from capturing the underlying transition topology, limiting their effectiveness in novel or non-stationary scenarios. To address this, we propose a novel multimodal multi-agent framework that achieves automatic workflow execution through a distinct two-phase pipeline. First, during an offline discovery phase, the architecture adaptively constructs a topological knowledge base from fragmented execution logs. During inference, agents leverage Adaptive Retrieval-Augmented Generation (RAG) over this fixed, pre-established graph, coupled with a closed-loop collaborative verification protocol to dynamically self-correct and navigate. This graph-based approach facilitates superior task decomposition and adaptive navigation performance. We validate our framework in a real-world context, demonstrating its ability to maintain high reliability and semantic awareness even with limited training data.

Epidemic forecasting faces a fundamental challenge: human behavior dynamically responds to disease spread, creating feedback loops that induce distribution shifts at policy intervention points. This renders data-driven models unreliable under distribution shift. We propose \textbf{SL-BiLEM} (Structured Learnable Behavior-in-the-Loop Epidemic Model), leveraging physical constraints as regularization for robust extrapolation. The framework decomposes effective transmission as $β_{\text{eff}}(t,g) = β_0(g) \times m_{\text{policy}}(t) \times m_{\text{media}}(t) \times m_{\text{comp}}(t,g)$, where monotonicity, smoothness, and bounded-jump constraints on the learned compliance function maintain predictive validity under novel policy regimes. Beyond forecasting, SL-BiLEM enables counterfactual analysis for intervention decision support. We validate forecasting on three real-world datasets (cruise ship, school influenza, and school-district COVID-19 surveillance) and evaluate counterfactual recovery on synthetic benchmarks with known ground truth. SL-BiLEM demonstrates: (1) 76% improvement over neural-mechanistic baselines, with only 53% OOD degradation versus 1142% for neural baselines under policy-induced shift; (2) 100% bootstrap CI coverage across 27 synthetic counterfactual experiments; and (3) Treatment Effect Accuracy exceeding 0.85. These results establish SL-BiLEM as an interpretable tool for public health decision-makers seeking accurate prediction and principled intervention planning.

Security risk analysis typically treats control effectiveness as a static input, yet controls degrade through configuration drift, depend on monitoring systems that may themselves be degraded, and compete for finite remediation budgets. The FAIR Controls Analytics Model (FAIR-CAM) provides the theoretical framework for these dynamics but has so far remained theoretical. We present the first agent-based model to operationalize the core FAIR-CAM dynamics, making control physiology computationally observable, and release the implementation as open source. The simulation implements eight agent types, a multiplicative defense-in-depth susceptibility formula, a three-source variance model, budget-constrained remediation, and a narrative causation engine that produces a complete causal trace for every loss event. In a hospital ransomware scenario (N=1,000 iterations), three organizational dynamics emerge that static analysis cannot represent. First, emergent operational efficacy diverges from the analytical FAIR-CAM formula by approximately 17 percent, driven by correlated extrinsic variance; the divergence grows linearly with extrinsic frequency and vanishes under purely intrinsic drift. Second, a sharp queueing regime transition in the remediation pipeline approximately 2.8x expected loss when budget falls below a scenario-specific threshold (5-10 engineer-hours/month). Third, cascading monitoring failures propagate through the VMC topology: a single degraded VMC silently compounds undetected variance across the controls it manages. These dynamics are structural properties of the FAIR-CAM architecture and should generalize beyond the specific scenario studied.

Emergency departments (ED) face challenges in patient care and resource management. We propose to explore optimization strategies in a realistic and flexible model and develop a hybrid Discrete Event Simulation (DES) and Agent-Based Model (ABM) simulating highly configurable ED environments. We specifically focus on the validation of the modeling approach. We derive configurations for ED sizes, patient load, and staffing from real-world studies. We then validate the model expressivity by matching its key performance indicators and metrics with their values known from literature. We proceed by implementing scientifically established and practice-proven resource optimization strategies. Comparing the documented real-world outcomes with our model's results demonstrates that the DES-ABM based simulation can effectively replicate real-world ER dynamics under interventions. We lastly integrate a Proof-of-Concept multi-agent system (MAS) that can autonomously explore resource allocation strategies within the simulated ER environment based on a temporal ledger of ED event records. This modular DES-ABM-MAS framework offers a powerful tool to explore resource optimization strategies in emergency departments.

Large language models (LLMs) can generate high-level diverse phenomena without explicitly programmed rules. This capability has led to their adoption within different agent-based models (ABMs) and social simulations. Recent studies investigate their ability to generate different phenomena of interest, for example, human behavior on social media platforms or alien behavior in game-theoretic scenarios. However, capability, prediction, and explanation are different--drawing from the philosophy of science and mechanisms literature, explanation requires showing, to some degree, how a phenomenon is produced by related organized entities and activities. For modelers, describing the characteristics of an experiment or whether a simulation provides progress in capability (or explanation), can be difficult without being grounded in potentially distant research areas. We integrate recent work on LLM-ABMs with contemporary philosophy of science literature and use it to operationalize a definition of 'plausibility' in a four-level scale. Our scale separates the evaluation of a model's generative sufficiency (ability to reproduce a phenomenon) from its mechanistic plausibility (how the phenomenon could be produced), and clarifies the distinct roles of different models, such as predictive and explanatory ones. We introduce this as the Mechanism Plausibility Scale.

Agent-based models (ABMs) are increasingly used in macroeconomics, but their analysis still often relies on ad hoc Monte Carlo campaigns with heterogeneous statistical effort across parameter settings. We show how statistical model checking (SMC), implemented through MultiVeStA, can provide a principled analysis layer for a realistic macroeconomic ABM without rewriting the simulator in a dedicated formalism. Our case study is the heuristic-switching Keynes+Schumpeter(K+S) model, analysed hrough a transient sensitivity campaign over one-parameter sweeps, two macro observables (unemployment and GDP growth), and one auxiliary micro-level probe (market share) on the post-warmup phase of a 600-step horizon. The analysis is driven by reusable temporal queries, observable-specific precision targets, and confidence-based stopping rules that automatically determine the simulation effort required by each configuration. Results show a clear contrast across parameter families: macro-financial and structural sweeps produce the strongest transient effects, whereas several heuristic-rule sweeps remain much weaker under the same precision policy. More broadly, the paper shows that SMC can support reproducible and informative quantitative analysis of substantively rich economic ABMs, while making uncertainty estimates and simulation cost explicit parts of the reported results.

ML models in healthcare are typically evaluated using curated real-world EHR data. A key limitation of such evaluations is that they may fail to assess the robustness of ML models to changes in the data at deployment, which is a common issue because EHR data used for ML model development cannot capture all such changes. Mass casualty incidents (MCIs) caused by disasters are critical instances where this will be an issue, as they induce rare, uncertain, and novel changes to routine system conditions. Because real-world EHR data from MCIs are often limited or unavailable, assessing ML robustness under such conditions before deployment remains challenging. Here, we propose an agent-based modelling approach for generating synthetic EHR data to evaluate the robustness of ML models under MCI scenarios. We use real-world EHR data to develop and calibrate an agent-based model (ABM) of an emergency department (ED) that explicitly models patient arrivals, resource capacity, and clinical workflow. By changing these system conditions to reflect plausible MCI scenarios, the ED model generates synthetic versions of the real-world EHR data that exhibit shifts in system behaviour. Using these synthetic data, we test ML models for predicting length of stay. We observed consistent declines in recall under MCI conditions relative to baseline system conditions, resulting in an increase in the number of patients with prolonged length of stay that were missed by the ML models. These results highlight the impact of changes in system conditions on patient outcomes, EHR data, and ML model performance. Our work establishes ABM-based synthetic EHR data generation as a proactive and systematic approach for evaluating the robustness of ML models under MCI or other system conditions not captured in real-world EHR data, supporting the safer and more effective deployment of ML models in healthcare systems.

Agent-based model (ABM) are a kind of computer model that makes it possible to simulate a set of autonomous interacting programs called agents in a shared virtual environment. Among other application field, it has been commonly used to simulate social phenomena such as urban segregation, opinion dynamic or epidemiological crisis [1]. Recently, a research emphasis has been put on ABM to study in silico the impact of non-pharmaceutical interventions to mitigate the SARS-CoV-2 outbreak of 2020, with few of them that had a great impact on global political responses [2]. Among the model used COMOKIT [3] has been design to simulate the every-day-life of inhabitant of various cities in Vietnam and test policy interventions for various COVID-19 spread scenarios. Such endeavor required huge computational power to handle a huge number of simulation replication over a large set of parameters. In this proposal we present a python package that enables to easily generate, explore and build reports for any COMOKIT experiment to be launched over High-Performance Computing (HPC) infrastructure.

To understand complex system dynamics in dairy farming, it is essential to use modeling tools that capture farm heterogeneity, social interactions, and cumulative environmental impacts. This study proposes an agent-based modeling (ABM) framework to simulate nitrogen management and the adoption of low-emission fertilizer across 295 Irish dairy farms over a 15-year period. Using empirical data, the model represents farm communication through a social network, capturing peer influence and discussion group dynamics, where adoption probabilities are driven by social contagion, farm-scale characteristics, and policy interventions such as subsidies and carbon taxes. The framework estimates sectoral greenhouse gas emissions, cumulative abatement, and private-social cost trade-offs, using Monte Carlo simulation and sensitivity analysis to quantify uncertainty. The model shows strong agreement with observed adoption trajectories ($R^2 = 0.979$, RMSE = 0.0274) and is validated against empirical data using a Kolmogorov-Smirnov test (D = 0.2407, p < 0.001), indicating its ability to reproduce structural patterns in adoption behavior. Adoption dynamics are further characterized using a logistic diffusion model consistent with Rogers' innovation diffusion theory, capturing progression from early adoption to a saturation level of approximately 91%. By framing decarbonization as a socio-technical diffusion process rather than a purely economic optimization problem, this study provides an in silico policy laboratory for evaluating the robustness and diffusion speed of climate mitigation strategies prior to implementation.

This paper presents a configurable, grid-aware Agent-Based Model (ABM) for the systematic analysis of electric vehicle (EV) charging systems under configurable infrastructure and operational conditions. The model integrates heterogeneous EV behavior, charging column constraints, and a shared Energy Sandbox that regulates aggregate power allocation, enabling the joint study of user-centric charging dynamics and facility-level power behavior. Implemented in Python using the SimPy discrete-event framework, the approach supports scalable, event-driven simulations across varying system sizes, charger compositions, and scheduling strategies. A representative workplace charging scenario is investigated to illustrate how infrastructure configuration and coordination mechanisms influence energy delivery performance, infrastructure utilization, and aggregate load characteristics. The results highlight the context-dependence of infrastructure suitability and demonstrate how charging strategies and charger types reshape both service-level outcomes and grid-facing behavior. The proposed ABM provides a flexible and extensible simulation environment for exploring technical, operational, and grid-aware aspects of EV charging ecosystems, and for serving as a methodological basis for subsequent studies on advanced coordination strategies beyond the specific scenario analyzed in this study.

Theory and empirical research on management teams' influence on firm performance have witnessed continuous development, and by now incorporate numerous details. Classic, experiment-based studies examining social systems collect vast amount of data, but often times investigate only the first one or two modes of the distribution of measured variables, and experience difficulty in analyzing the effect of context. For example, in functional diversity research, management teams are described by measures incorporating complex distributions of capabilities of individual managers and teams of managers. To investigate the effect of hidden distributions, and the effect of functional diversity composition on team communication and performance, we developed an agent-based model, and conducted a series of simulation experiments. Modeling results show that depending on the context, such as communication scheme among interacting agents, or their functional composition, intrapersonal functional diversity (IFD), and dominant function diversity (DFD) might enhance or reduce performance and communication among agents. Furthermore, simulation results also suggest that a third measure is required alongside IFD and DFD capturing the aggregate expertise of the team to comprehensively account for empirical findings.

Digital twins of natural systems must remain aligned with physical systems that evolve over time, are only partially observed, and are typically modeled by mechanistic simulators whose parameters cannot be measured directly. In such settings, model adaptation is naturally posed as a simulation-based inference problem. However, sparse and indirect observations often fail to identify a unique and optimal calibration, leaving several simulator parameterizations compatible with the available evidence. This article presents a GFlowNet-based approach to model adaptation for digital twins of natural systems. We formulate adaptation as a generative modeling problem over complete simulator configurations, so that plausible parameterizations can be sampled with probability proportional to a reward derived from agreement between simulated and observed behavior. Using a controlled environment agriculture case study based on a mechanistic tomato model, we show that the learned policy recovers dominant regions of the adaptation landscape, retrieves strong calibration hypotheses, and preserves multiple plausible configurations under uncertainty.

Understanding social polarization requires integrating insights from psychology, sociology, and complex systems science. Agent-based modeling provides a natural framework to combine perspectives from different fields and explore how individual cognition shapes collective outcomes. This study introduces a novel agent-based model that integrates two cognitive and social mechanisms: the desire to be unique within a group (optimal distinctiveness theory) and the tendency to simplify complex information (cognitive compression). In the model, virtual agents interact in pairs and decide whether to adopt each other's opinions by balancing two opposing drives: maximizing opinion diversity within their local social group while simplifying the overall opinion landscape, with both evaluated using Shannon entropy. We show that the combination of these mechanisms can reproduce real-world patterns, such as the emergence of distinct heterogeneous opinion clusters. Moreover, unlike many existing models where opinions become fixed once opinion groups form, individuals in our model continue to adjust their opinions after clusters emerge, leading to ongoing variation within and between opinion groups. Computational experiments reveal that polarization emerges when local group sizes are moderate (consistent with Dunbar's number), while smaller groups cause fragmentation and larger ones hinder distinct cluster formation. Higher cognitive compression increases unpredictability, while lower compression produces more consistent group structures. These results demonstrate how simple psychological rules can generate complex, realistic social behavior and advance understanding of polarization in human societies.

The integration of Large Language Models (LLMs) into social simulation has generated considerable enthusiasm, but also raises substantial methodological and epistemological challenges. This critical review examines the use of LLMs as cognitive or decision-making components of simulated agents from a computational social science perspective. Rather than treating the psychological evaluation of LLMs as separate from simulation mechanics, we argue that their behavioural and epistemic limitations can become systemic vulnerabilities when scaled to multi-agent societies. We first map the rapidly evolving landscape of LLM-driven platforms, ranging from small narrative sandboxes to population-scale and spatially structured simulations. We then develop a unified critical framework for analyzing the Micro-to-Macro Validity Gap: the propagation and amplification of micro-level limitations, including hallucinations, stochastic inconsistency, representational biases, and alignment effects, into macro-level risks such as the Fluency Fallacy, convergence toward an average persona, and automation bias. We identify contexts in which LLM-based agents offer genuine operational value, including serious games, participatory environments, and exploratory modelling, while distinguishing these uses from confirmatory research and precise social forecasting. Finally, we examine theory-driven hybrid architectures that embed LLMs within explicit, mechanistic, and reproducible Agent-Based Modelling (ABM) frameworks. We argue that such architectures offer a promising but not sufficient path toward improving epistemic control: their validity depends on multi-level evaluation of environmental dynamics, individual behaviour, cross-level interactions, and aggregate outcomes, and they remain vulnerable to the risk of physics washing.

Understanding the dynamic evolution of complex social phenomena requires both high-fidelity modeling of human behavior and large-scale simulations. Traditional agent-based models (ABMs) have been employed to study these dynamics, but are constrained by simplified agent behaviors. Recent advances in large language models (LLMs) enable agents to exhibit sophisticated social behaviors, yet face significant scaling challenges. We present Light Society, an agent-based simulation framework that advances both fronts. Light Society formalizes social processes as structured transitions of agent and environment states, governed by a set of LLM-powered simulation operations. Joint algorithmic and system optimizations, particularly a mixture-of-models engine that combines full LLMs with distilled surrogates, enable Light Society to efficiently simulate societies with over one billion agents. Grounded in real-world demographic profiles from the World Values Survey, simulations of Trust Games and opinion diffusion at up to one billion agents demonstrate Light Society's high fidelity and efficiency in modeling diverse social phenomena, providing researchers with a practical foundation for hypothesis testing and the study of emergent collective behaviors at planetary scale.

This paper presents a hybrid modeling approach that couples an Agent-Based Model (ABM) with a partial differential equation (PDE) model in an epidemic setting to simulate the spatial spread of infectious diseases using a compartmental structure with seven health states. The goal is to reduce the computational complexity of a full-ABM by introducing a coupled ABM-PDE model that offers significantly faster simulations while maintaining comparable accuracy. Our results demonstrate that the hybrid model not only reduces the overall simulation runtime (defined as the number of runs required for stable results multiplied by the duration of a single run) but also achieves smaller errors across both 25% and 100% population samples. The coupling mechanism ensures consistency at the model interface: agents crossing from the ABM into the PDE domain are removed and represented as density contributions, while surplus density in the PDE domain is used to generate agents with plausible trajectories derived from mobile phone data. We evaluate the hybrid model using real-world mobility and infection data for the Berlin-Brandenburg region in Germany, showing that it captures the core epidemiological dynamics while enabling efficient large-scale simulations. These results demonstrate that the proposed ABM-PDE framework provides a robust and computationally efficient alternative to full-scale agent-based simulations, making it suitable for realistic epidemic modeling and scenario analysis.