Identity-Conditioned Latent Diffusion Models

Medical counterfactual generation modifies images to change model predictions for interpretability. However, existing diffusion-based approaches are often prohibitively slow and memory-intensive, making them difficult to apply in high-resolution settings. Moreover, existing masking strategies are tightly coupled with pixel-space representations, making them incompatible with latent-space diffusion editing. To address these challenges, we propose MedDiME, a latent-space classifier-guided diffusion framework that reduces computational and memory overhead while introducing a latent-compatible, gradient-driven adaptive masking mechanism for spatially precise medical counterfactual generation. Extensive experiments demonstrate that MedDiME achieves high-quality counterfactual generation with significant efficiency gains compared to prior classifier-guided diffusion baselines, achieving up to 40 times faster inference and 13 times lower peak GPU memory usage.

Agricultural parcel polygons play a fundamental role in geospatial applications such as precision agriculture, land administration, and crop monitoring. Beyond regular polygon geometry and low vertex redundancy, practical parcel maps should avoid topological conflicts and preserve common boundaries between adjacent fields. Yet this requirement remains largely unresolved: segmentation-based methods mainly produce parcel masks or raster boundary cues and rely on heuristic raster-to-vector conversion, instance- and contour-based methods reconstruct parcels independently, and recent vector-oriented methods improve polygon regularity but do not explicitly recover adjacent parcels from a shared topological structure. To address this gap, we propose a semantic-guided diffusion framework for topologically consistent agricultural parcel vectorization. It couples joint edge--vertex latent diffusion with supervised multi-cue conditioning to generate geometrically regularised parcel-boundary and vertex primitives while suppressing false-positive responses. A topology-aware parcel polygon reconstruction method then converts these primitives into regular polygons by reconstructing parcel faces from a common planar graph, enabling adjacent predicted parcels to reuse shared boundaries and avoid mutual interior intrusion. Extensive experiments on the AI4SmallFarms and iFLYTEK datasets evaluate parcel vectorization in terms of pixel-level coverage, geometric fidelity, object-level correctness, and topological consistency. The results show strong and competitive performance, with zero measured intrusion ratio and the highest shared-edge recall, demonstrating the potential of the proposed framework for accurate, regular, and topologically consistent agricultural parcel vectorization.

Uncertainty arising from inter-observer variability in medical image segmentation plays an important role in developing treatment plans. Research in this area is inhibited by the lack of multiple annotations for large-scale medical datasets, especially for volumetric data, which suffers from additional scaling and computational complexity challenges. Flow matching has emerged as a powerful framework for generative modelling and has also been demonstrated to maintain strong performance when working with latent representations of images. In this work, we introduce a latent-to-latent flow technique for stochastic segmentation of medical volumes via encoded representations of both the image and label space. We evaluate our method on two challenging applications covering delineation uncertainty for radiotherapy planning and multiple organ structure segmentation, improving efficiency up to 14x compared with full resolution models while maintaining clinically relevant performance.

Diffusion models have achieved strong results in high-fidelity image synthesis, but their iterative sampling process makes large-scale generation computationally expensive. This limitation is especially relevant when generating synthetic face datasets for face recognition, where a large number of subjects with many samples in different poses, expressions, ages, etc., are required. In this work, we show that identity-conditioned face synthesis can be performed at a substantially lower computational cost by a latent Consistency Model with few iterations, without compromising image quality. For training, we distill knowledge from the foundation Diffusion Model Arc2Face (teacher) by adapting its original text-to-image pipeline to an embedding-to-face setting, replacing textual prompts with ArcFace identity embeddings. Our distilled model (student) generates identity-conditioned face images with an average inference time of 0.4819 seconds per image, compared with 2.102 seconds for Arc2Face, resulting in a 4.36$\times$ speed-up. Quantitative results, based on FID scores, show that the distilled model remains competitive with Arc2Face across all evaluation protocols. On 100k generated images, it achieves near-parity on CelebA (13.921 vs. 12.928) and outperforms the teacher on WebFace42M (9.317 vs. 9.802). Further evaluations on Synth-500 and AgeDB show a moderate performance gap for the former but comparable results for the latter. These results indicate that Arc2Face can be accelerated through task-specific latent consistency distillation while preserving high image quality for large-scale synthetic face generation. Our proposal is publicly available at https://github.com/UFPR-IPASP-PR/FaceRec-IdentityConsistency.

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is central to breast cancer imaging, but gadolinium administration increases scan burden and motivates contrast-reduced alternatives, including synthetic contrast generation. We propose a latent bridge matching (LBM) framework for synthesizing peak-enhanced breast DCE-MRI from pre-contrast images in the MAMA-SYNTH challenge setting. Instead of starting from Gaussian noise as in conventional latent diffusion models (LDMs), the proposed model learns a conditional bridge between paired pre-contrast and peak-enhanced VAE latents. A latent UNet predicts the remaining correction from intermediate bridge states to the peak-enhanced latent, enabling iterative refinement while keeping the trajectory anchored to patient-specific anatomy. We evaluated two LBM conditioning variants on 91 DUKE validation cases. For the tumor-conditioned variant, tumor masks were used as conditioning inputs. Tumor-conditioning improved performance compared with pre-contrast conditioning, reducing MSE from 1.023 to 0.940 and FRD from 7.523 to 4.716, while increasing tumor SSIM from 0.355 to 0.429. The tumor-conditioned LBM also outperformed the evaluated LDM baseline on this validation cohort. These results suggest that latent bridge matching is a promising pre-contrast-anchored formulation for virtual contrast enhancement, while further work is needed to validate generalization and remove dependence on ground-truth tumor masks at inference.

We introduce the Intrinsic Hybrid Latent Diffusion Model (ILDM), a generative framework that integrates probabilistic dimensionality reduction with geometry-aware diffusion on unknown manifolds. While diffusion models (DMs) have achieved state-of-the-art results in high-dimensional data synthesis, they rely on large training datasets and ignore intrinsic geometric structure. Latent diffusion models (LDMs) address the high dimensionality by learning a latent space, but they typically impose a Euclidean structure, failing to capture the underlying manifold geometry, especially problematic in data-sparse regimes. ILDM addresses these limitations by interpreting the latent space as a chart of an unknown Riemannian manifold, with geometry and uncertainty quantified through a probabilistic decoder. The forward process is a hybrid diffusion that switches between Riemannian and Euclidean dynamics based on local uncertainty, where the Riemannian component is governed by a probabilistic metric tensor derived from the decoder. To learn the generative dynamics, we introduce an approximate denoising score matching method tailored to the hybrid diffusion setting, enabling a backward process defined by hybrid Langevin dynamics. Experiments on COIL-100, MNIST, and cardiac MRI datasets demonstrate that ILDM significantly improves generation quality, achieving lower FID and LPIPS scores compared to standard diffusion and latent diffusion models.

Multimodal named entity recognition (MNER) determines whether each candidate span and entity-type hypothesis is supported by joint textual and visual evidence. Existing imagine-and-compare verifiers map each (span, type) pair to one predicted visual feature, compressing diverse visual realisations into a single prototype and providing a compatibility score without explicit probabilistic semantics. We introduce DiffImaginE, which formulates MNER type verification as conditional latent diffusion inference. Given span-localised visual evidence, a type-conditioned denoiser predicts noise injected into its standardised latent. The resulting denoising error provides an ELBO-consistent surrogate for type-conditional negative log-likelihood, allowing competing type hypotheses to be ranked by how well they explain the observation. DiffImaginE retains a standard multimodal encoder stack and replaces the deterministic verifier with a classifier-free-guided diffusion scorer trained using Min-SNR weighting. We directly supervise per-type diffusion scores as classification logits, learn aggregation across noise levels, and use antithetic sampling to reduce Monte Carlo comparison variance. Our analysis shows that classifier-free guidance sharpens the induced type posterior and characterises when antithetic pairing reduces variance at equal denoiser cost. Experiments on Twitter-2015 and Twitter-2017 show consistent gains over a matched deterministic ImaginE control under the same encoder, auxiliary objectives, and evaluation protocol, supported by ablations and paired significance tests.

Layout-to-image diffusion models have achieved impressive semantic controllability by conditioning generation on category-level segmentation maps. However, such category-aligned control is not necessarily instance-addressable: multiple nearby objects from the same category are often treated as a shared semantic region, leading to ambiguous boundaries, averaged appearances, and feature confusion among instances. This limitation is particularly evident in urban scene synthesis, where small and crowded pedestrians or vehicles require fine-grained instance separation while preserving global scene consistency. In this paper, we propose InstancePin, an instance-addressable layout-to-image diffusion framework that pins each object instance with an explicit coordinate anchor. Instead of directly injecting instance masks into the pretrained backbone, InstancePin introduces an independent instance-aware adapter to preserve the category-level generation prior while learning instance-specific spatial control. For each instance, its center coordinate is encoded with Fourier features and projected into a coordinate token, which serves as a spatial anchor queried by latent image features through coordinate pinning attention. To make these anchors spatially meaningful, we further supervise the coordinate attention maps with instance regions, encouraging each coordinate token to activate its corresponding object area. Finally, an instance-mask guided fusion module routes pretrained backbone features to non-instance regions and adapter features to instance regions, enabling local instance refinement without sacrificing global semantic fidelity. Extensive experiments on Cityscapes demonstrate that InstancePin mitigates instance entanglement in dense layouts and improves both image fidelity and semantic consistency.

Unsupervised medical anomaly detection learns normal anatomical patterns from healthy training images and identifies deviations at test time. Reconstruction-based and diffusion-based methods commonly use the difference between an input image and its reconstruction as anomaly evidence. However, this residual can be ambiguous. Expressive models may preserve pathological structures, while benign anatomical variation, imaging noise, and acquisition differences may also produce large reconstruction errors. We propose discriminative mask-guided diffusion (DMD), a medical anomaly detection framework that complements residual-based localization with reconstruction-shift discrimination. DMD first learns a compact quantized latent representation of normal images. Localized masks then perturb selected latent regions, and a latent diffusion model reconstructs the perturbed representations. The resulting reconstructions are paired with their original normal images to define a self-supervised classification task. At inference, the classifier provides a learned image-level anomaly score, while the residual between the input and its diffusion-based reconstruction yields a pixel-level anomaly map. Experiments on five datasets spanning brain MRI, breast ultrasound, and chest radiography show that DMD achieves the best overall performance among the state-of-the-art baseline methods.

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is essential for breast cancer management, but reliance on gadolinium-based contrast agents (GBCAs) restricts use in contraindicated populations, prolongs scan protocols, and presents environmental toxicity concerns. Contrast synthesis offers a non-invasive alternative; however, existing approaches struggle to balance spatial realism with temporal continuity, suffer from slow iterative sampling, underutilize structural priors, and lack clinical validation. We propose a novel conditioned latent transport framework that predicts contrast enhancement in a single forward pass. By anchoring the latent trajectory to the pre-contrast anatomy and applying continuous time conditioning, the model synthesizes patient-specific contrast evolution at any acquisition time. The proposed approach outperforms baseline and the state-of-the-art models across spatial, perceptual, temporal, and distributional metrics. Evaluated on an independent external cohort, the method demonstrates robustness to domain shifts induced by scanner noise as well as differing acquisition protocol. Furthermore, our synthetic contrast enhancement significantly improved downstream tumor segmentation performance, yielding a 22.4% relative increase in Dice coefficient (0.60 vs. 0.49 baseline pre-contrast, p < 0.01), reducing boundary segmentation error by over 39%, while outperforming all other generative model baselines. Finally, a reader study involving four breast radiologists evaluated the image quality, kinetic fidelity, and diagnostic viability of our synthesized sequences across 40 randomly selected cases. The results demonstrated that in 70% of cases, synthesized images provided sufficient clinical information to support the same management decisions as real DCE-MRI, suggesting a path toward safer and faster contrast-free or contrast-reduced imaging workflows.

Generative diffusion models have revolutionized facial image synthesis, yet robust identity preservation in high resolution outputs remains a critical challenge. This issue is especially vital for security systems, biometric authentication, and privacy sensitive applications, where any drift in identity integrity can undermine trust and functionality. We introduce Diff-ID, a diffusion based framework that enforces identity consistency while delivering photorealistic quality. Central to our approach is a custom 210K image dataset synthesized from CelebA-HQ, FFHQ, and LAION-Face and captioned via a fine tuned BLIP model to bolster identity awareness during training. Diff-ID integrates ArcFace and CLIP embeddings through a dual cross attention adapter within a fine tuned Stable Diffusion UNet. To further reinforce identity fidelity, we propose a pseudo discriminator loss based on ArcFace cosine similarity with exponential timestep weighting. Experiments on held out and unseen faces show that Diff-ID does not exceed InstantID in raw ArcFace Face Similarity, but achieves substantially lower FID and the strongest FIQ based identity--realism trade off among the evaluated methods. We also present a unified DDIM based morphing pipeline that enables qualitative facial interpolation without per identity fine tuning. We further argue that identity preservation and photorealism should be evaluated jointly rather than in isolation, as high identity similarity alone does not guarantee realistic outputs. To make this trade off explicit, we report Face Image Quality (FIQ) as a complementary ratio based score that combines identity similarity and perceptual realism while keeping FS and FID as the primary metrics.

Mobile infrared-visible imaging typically pairs a compact infrared sensor with a high-resolution visible camera for complementary perception. While cross-sensor misalignment caused by different optics, viewpoints, fields of view, and exposure timings hinders practical deployment. In this paper, we propose BeyondFusion, a unified latent diffusion framework for calibration-free visible-guided infrared super-resolution and infrared-visible fusion tasks. The proposed framework supports both task-specific training and joint training where two tasks are optimized and executed as two readouts of the same generative process. Instead of relying on explicit registration or geometric warping, BeyondFusion introduces a cross-modal self-aligning (CMSA) module into the denoising U-Net. CMSA reorganizes infrared and visible latent tokens into a shared attention space to learn content-adaptive cross-modal correspondence during the denoising process. Together with misalignment augmentation module, the model is facilitated to exploit visible structural and semantic cues while preserving thermal consistency, enabling high-frequency infrared reconstruction and informative fused-image generation under uncalibrated conditions. Extensive experiments on public benchmarks and a mobile infrared-visible imaging system show strong performance across aligned inputs, low-resolution infrared observations, synthetic misalignments, and real mobile captures with unsynchronized sensors. Ablation studies, unified training analysis, and downstream pedestrian detection further validate the effectiveness of BeyondFusion for calibration-free multimodal imaging.

We present a privacy-preserving framework for synthetic lung CT slice generation developed for the Image-CLEFmed GANs 2026 challenge. The approach combines Optimal Transport Conditional Flow Matching with privacy-oriented training and a post-generation "Supervisor" pipeline that filters generated candidates in learned geometric latent spaces using autoencoder embeddings, Determinantal Point Processes, and Stein Kernel Thinning. Official results show a strong realism-privacy trade-off, with the best-performing model achieving a Privacy Preservation Score of 0.549 and competitive visual fidelity with an FID of 0.3290. While the proposed geometric filtering substantially reduces nearest-neighbor memorization and membership-inference leakage, persistent patient re-identification scores indicate that preventing direct image copying is not sufficient to remove deeper patient-specific anatomical identity, highlighting an important frontier for future privacy-preserving medical image generation.

Accurate routability estimation during physical design is important for reducing costly post-routing iterations. Prior learning-based methods treat this task as deterministic prediction, mapping placement-stage features to a single congestion or DRC outcome. We instead formulate routability estimation as a conditional generation problem, where both routing congestion and DRC violations are modeled as spatially structured routability fields. Our framework, Conditional Latent Diffusion for Routeability estimation (CLDRoute), uses physics-aware conditioning and task-specific latent modeling to handle the different characteristics of congestion and DRC maps. This allows our method to supports sample-based inference, producing both a mean prediction and a spatial uncertainty estimate for the same input design. On CircuitNet 2.0 (N28), our method achieves, for DRC violation generation, an SSIM of 0.9678, an MAE of 0.0028, and a TopK@1% of 0.3494; for congestion generation, it achieves an SSIM of 0.9031, an MAE of 0.0286, and an NZ-Pearson of 0.3692. Overall, our framework provides a more practical view of routability at placement by generating both the expected outcome and its uncertainty.

Deploying object-centric models for real-world scene understanding typically requires complex pipelines to achieve both robust scene decomposition and high-fidelity generation. Recent diffusion-based approaches have improved visual quality, but they almost universally rely on heavy, pretrained generative priors (e.g., Stable Diffusion) and external VAE latent spaces. In this paper, we propose Slot-RAE, a much simpler, fully integrated framework that operates directly within the continuous semantic feature space of visual foundation models (e.g., DINOv3). Slot-RAE employs a feature-space diffusion process using a Diffusion Transformer (DiT) decoder and a Representation Alignment (REPA) head. Unlike existing diffusion-based objectcentric methods that rely heavily on subsidized text-toimage priors, the generative core of Slot-RAE (Slot Attention and the DiT) is trained from scratch within the frozen VFM feature space. This eliminates the need for VAE bottlenecks and task-agnostic generative pre-training. Experiments on the COCO dataset demonstrate that despite its architectural simplicity, Slot-RAE achieves state-of-the-art results. It delivers comparable unsupervised object discovery, higher-fidelity image reconstruction, and robust zero-shot compositionality, all while being significantly faster and more computationally efficient than existing object-centric latent diffusion models.

Forecasting the future anatomy of slow-evolving neurodegenerative diseases could enable earlier, more targeted intervention and improve clinical trial design, but it remains challenging because true progression signals are subtle in longitudinal MRI. In this low-signal regime, transferring modern generative sequence models directly is unreliable: training is dominated by stable baseline anatomy and confounded by dense, sample-specific nuisance variation. We first provide a theoretical analysis that explains these failures through two modes. Identity collapse occurs when optimization is driven toward reproducing the current anatomy, which prevents the model from learning faint temporal change. The continuous interpolation trap arises when standard smooth networks cannot separate localized biological drift from pervasive noise, which leads to spurious changes that diffuse across the volume. To address both issues, we propose Latent Drift, a progressive generative framework that learns change in a compressed semantic representation rather than synthesizing full-resolution anatomy. This design removes pixel-level identity from the prediction target and concentrates model capacity on progression-relevant dynamics. We further apply Finite Scalar Quantization to the learned change representation, which suppresses small, high-frequency nuisance fluctuations while preserving consistent structural drift. Experiments on longitudinal 3D brain MRI show that Latent Drift improves patient-specific neuro-forecasting over diffusion and autoregressive transformer baselines across generative fidelity and clinically relevant evaluation metrics. Project page: \href{https://cutepkq.github.io/latent-drift}{https://cutepkq.github.io/latent-drift}.

Deep learning models for medical diagnosis frequently exhibit substantial performance disparities across sensitive subgroups (e.g., race, sex), even when average accuracy is high. While generative data augmentation offers a route to mitigate this, existing strategies are suboptimal; they typically address only one or two dependency channels between sensitive attributes and image features. We formalize the medical image formation process via a structural causal model, revealing that sensitive attributes actually influence image content through four distinct pathways-a structural complexity neglected by prior works. Based on this insight, we introduce CIPHER (Causal Intervention Pathways for Healthcare Equity and Robustness), a framework designed to systematically intervene on all four causal paths. To achieve this, CIPHER utilizes a diffusion backbone equipped with classifier-free guidance and null-text inversion. This technical design enables the faithful reconstruction of patient-specific anatomy while allowing for the precise, editable synthesis of counterfactuals required to break sensitive dependency chains. We tested CIPHER using chest X-ray and dermoscopy benchmarks across both standard and shifted data distributions. By employing a multi-pathway intervention strategy, our model reduced worst-group disparities by an average of 35.8% compared to disease-conditioned synthesis baselines, while also improving total diagnostic accuracy

Reconstructing diffusion tensors from sparse DWIs is critical for accelerating Diffusion Tensor Imaging (DTI) in clinical settings, yet current deep learning approaches frequently yield anatomically inconsistent or physically implausible tensors. We introduce TensorLDM, a component-wise latent diffusion model that processes the six tensor components through two group-specific encoders (for diagonal and off-diagonal elements) while maintaining anatomical consistency via shared DWI conditioning. TensorLDM uses an Anatomy-Conditioned Autoencoder that encourages the latent to focus on tensor properties rather than re-encoding structural information. A shared Cross-Component Attention (CCA) mechanism, applied in both autoencoder refinement and diffusion fine-tuning, models inter-component dependencies, while a Mixture-of-Experts (MoE) DWI conditioner provides component-adaptive conditioning. On the Human Connectome Project (HCP) dataset under a single-shell, four-volume sparse acquisition, TensorLDM produces the most accurate downstream tractography and tensors with near-ground-truth physical validity (SPD-violation rate 1.54% vs. 1.40%), with the best or comparable voxel-wise reconstruction accuracy. Geodesic tensor error measured by the Log-Euclidean Metric (LEM) corroborates these gains.

Accurate classification of diffuse gliomas is often hindered by domain shifts across centers and a lack of large, annotated datasets. We propose the Anatomically-conditioned Latent Diffusion Model (ALDM), a novel framework for data-efficient, few-shot 3D volumetric MRI synthesis. ALDM utilizes a two-stage approach: a 3D variational autoencoder learns anatomical priors from a data-rich source domain, while a conditional latent diffusion model, guided by tumor masks via a ControlNet, generates structurally coherent volumes for a data-scarce target domain. Evaluated in an extreme few-shot setting with only 16 target images, ALDM outperformed GAN and hybrid baselines, achieving a superior Frechet Inception Distance (FID) of 85.40 and a downstream classification AUC of 0.987. Qualitative results confirm that the model preserves sharp pathology boundaries and cross-modal consistency, with visual fidelity improving progressively during training. By capturing essential diagnostic features, ALDM provides a robust tool for clinical data augmentation in low-resource settings. Our implementation is available at https://github.com/Analytics-Everywhere-Lab/anatomically-conditioned-LDM.

Modeling and sampling from the underlying distribution of asynchronous event sequences are crucial in various real-world applications, including social networks, medical diagnosis, and financial transactions. Existing autoregressive methods suffer from error accumulation during multi-step generation, while non-autoregressive diffusion methods are typically limited to fixed-length output sequences. In this paper, we propose Latent Block-Diffusion Temporal Point Processes (LBDTPP), a novel semi-autoregressive TPP framework that introduces a latent block diffusion mechanism for high-quality and variable-length event sequence generation. The core idea is to define an autoregressive probability distribution over event blocks in latent space and perform Gaussian diffusion within each block. By sequentially generating blocks while simultaneously sampling events in each block, LBDTPP preserves the length flexibility of autoregressive TPPs and inherits the parallel high-quality generation capability of diffusion models. Theoretically, we derive Wasserstein error bounds showing that, under suitable local approximation and prefix-stability assumptions, block-wise generation can reduce error accumulation compared with event-wise autoregressive generation. Extensive experiments on six real-world benchmark datasets demonstrate that LBDTPP outperforms state-of-the-art TPP baselines in both unconditional and conditional generation tasks. Further empirical analyses verify the benefits of latent-space diffusion and block-wise generation, and reveal the trade-off between generation quality and block size. Our code is available at https://github.com/Zh-Shuai/LBDTPP.

Stochastic segmentation seeks to represent multiple plausible masks for a single image, which is essential in safety- and quality-critical applications such as medical imaging or building defect inspection. Most existing methods introduce stochasticity by injecting continuous latent variables or by iterative denoising trajectories, whose stochastic sources are difficult to search or audit directly. We propose architecture distributions as a new stochastic source for segmentation: instead of sampling a latent variable or noise, we sample a discrete architecture from a learned distribution over operator choices at multiple searchable positions in a segmentation backbone. Each sampled architecture yields one mask through the selected active path, so inference depends on the executed subnet rather than the complete candidate bank. This approach also supports architectural provenance, since each output corresponds to a specific architecture configuration. To reduce collapse toward averaged masks, we train with set-level supervision by matching a set of architecture-sampled predictions to the annotation set using an IoU-based energy-distance surrogate. We further construct the candidate bank with evolutionary search, making the support of the stochastic source optimizable before distribution learning. The proposed method achieves state-of-the-art distribution matching and hypothesis coverage on LIDC-IDRI, and remains effective on two extension tasks. To the best of our knowledge, this is the first work to formulate stochastic segmentation as learning an architecture distribution and realizing output diversity through architecture sampling.

Leveraging Vision Foundation Models (VFMs) for camera-to-LiDAR knowledge distillation offers a promising solution to the scarcity of annotated data needed to represent the immense geometric and kinematic diversity of real-world autonomous driving (AD). However, current approaches typically treat VFMs as black-box teachers, relying exclusively on frame-wise feature similarity. Consequently, they do not fully exploit the teacher's layer-wise semantic structure and global context, as well as the rich spatiotemporal information inherent in LiDAR sequences. We propose HilDA, a self-supervised pretraining framework for LiDAR backbones that better captures the semantic what and geometric where needed for driving tasks. HilDA combines hierarchical distillation comprising multi-layer distillation for progressive semantic alignment and global context distillation for scene-level semantics, with a temporal occupancy diffusion objective promoting spatiotemporal consistency. Models pre-trained with HilDA achieve state-of-the-art results on cross-modal distillation benchmarks and outperform models trained via prior distillation approaches on 3D object detection, scene flow, and semantic occupancy prediction. Code available at: https://maxiuw.github.io/hilda.

Hematoma expansion (HE) after spontaneous intracerebral hemorrhage (ICH) is a major determinant of acute triage and treatment decisions in neurosurgical care. However, most existing methods provide either a binary expansion risk or a single follow-up volume, limiting uncertainty-aware decisions. We introduce HemExp, a clinically-guided latent diffusion model that generates patient-specific follow-up non-contrast CT images, along with segmentations of intraparenchymal and intraventricular hemorrhage. Generation is conditioned on baseline imaging, clinical variables, and an explicit expansion indicator, enabling controllable simulation of realistic clinical scenarios. HemExp uses a hemorrhage-aware multi-head variational autoencoder and models progression as the difference between baseline and follow-up latent representations with a conditional diffusion model. The model is trained on paired scans from 450 patients across multiple centers and evaluated on 107 patients from a held-out institution. HemExp produces spatial HE probability maps by generating multiple synthetic follow-up images per patient to estimate distributions of plausible follow-up hematoma volumes. Perturbing clinical inputs such as symptom-onset-to-imaging time or anticoagulant status shifts the predicted follow-up volume distribution. HemExp extends binary predictors and demonstrates robust estimation of clinically relevant outcomes in the imaging space, such as hematoma volume, intraventricular involvement, and mass effects. Overall, our results support controllable latent diffusion as a promising direction for uncertainty-aware modeling of early ICH progression.

The widespread adoption of face recognition (FR) technologies raises serious privacy concerns, as facial data can be exploited without consent. To address this challenge, we propose Adv-TGD, a generative adversarial attack framework that synthesizes photorealistic faces capable of impersonating target identities and deceiving face recognition systems. Built upon Stable Diffusion v2.1, Adv-TGD performs per-sample LoRA fine-tuning conditioned on concise textual prompts to generate natural yet adversarially manipulated identities. Unlike conventional identity attack approaches, our method optimizes lightweight cross-attention adapters for each source-target pair within a fixed-timestep denoising process. Latent blending is constrained by a face-local heatmap mask to ensure spatially precise identity manipulation while preserving non-sensitive regions. We introduce a composite objective that integrates masked epsilon-MSE reconstruction, thresholded identity divergence in FR embedding space, directional feature alignment, and source-similarity suppression to balance adversarial attack and visual realism. Optionally, LLaVA-generated attribute prompts enhance fine-grained semantic details without reintroducing identity cues. Under the black-box evaluation protocol, Adv-TGD attains an average attack success rate (ASR) of 85.90% across IR152, IRSE50, MobileFace, and FaceNet, surpassing the semantic SOTA baseline Adv-CPG by 6.25 points, the diffusion-based makeup method DiffAIM by 3 points, and the noise-based P3-Mask by 16 points. Despite its strong attack efficacy, Adv-TGD preserves high visual fidelity (PSNR = 28.18 dB, SSIM = 0.981). Furthermore, we demonstrate the flexibility of our framework by successfully extending it to in-the-wild datasets (LADN), general object classification (ImageNet), and transformer-based diffusion models (FLUX.1).

Clinical ultrasound images often contain artificial markers, such as measurement calipers and text, to assist diagnostic interpretation and comparison. However, these markers can introduce shortcut bias in downstream automated analysis, encouraging deep learning models to rely on marker-related cues rather than clinically meaningful anatomy. Existing marker removal methods are either mask-dependent and vulnerable to error propagation, or mask-free deterministic restorers that may over-smooth ultrasound texture and perturb unaffected background regions. To address these challenges, we present Echo-DM, a framework for ultrasound marker removal via conditional latent diffusion and region-aware fusion. Echo-DM follows a common encoder-diffusion-decoder pipeline, where a DiT-based conditional latent diffusion network performs global restoration and a region-aware fusion module enforces preservation-aware image-space refinement under end-to-end mask-free inference. Building on this fixed core design, we further instantiate Echo-DM-V and Echo-DM-R with VAE-based and RAE-based latent modules, respectively, which demonstrates that the Echo-DM architecture is compatible with diverse latent-module instantiations. Extensive experiments on Echo-PAIR, a large-scale paired clinical ultrasound dataset, demonstrate superior marker removal and strong anatomical fidelity compared with representative two-stage baselines, while providing favorable quality--efficiency trade-offs across deployment settings. Data, code and models will be released at https://github.com/MiliLab/Echo-DM.

Speech Emotion Conversion (SEC) aims to transform the emotion of a source utterance into a target emotion while preserving content and speaker identity. SEC on in-the-wild data is challenging due to the non-parallel nature of training data and complex real-world acoustics. Existing fixed-duration approaches either struggle to shift the emotion effectively (high quality, low conversion) or degrade speech naturalness (low quality, high conversion). We propose TargetSEC, an embedding-driven latent diffusion framework that generates emotion-focused style embeddings conditioned on speaker identity and continuous emotion. Unlike methods that diffuse over spectrograms, TargetSEC operates in a compact latent space. Experiments on the MSP-Podcast dataset show that TargetSEC outperforms current non-duration baselines and matches or exceeds the duration-prediction baseline in conversion MSE and naturalness without explicit temporal modeling.

Anatomical landmark detection is a fundamental task in medical image analysis supporting a wide range of diagnostic and interventional workflows. Although recent methods have achieved sub-millimetric localisation, accuracy alone is not sufficient for clinical deployment, requiring reliability and robustness in prediction. Despite its clinical relevance, the impact of representation learning in this context is still underexplored. In this work, we introduce CDPM-align, a multi-scale guidance-aligned conditional diffusion pre-training for anatomical landmark detection. Our experimental setup focuses on a few images and a few annotation regimes. Specifically, we employ three popular heterogeneous small-scale benchmark datasets for representation learning via conditional generative pre-training. Furthermore, we consider low-annotation scenarios for the downstream task of landmark detection, with 10 and 25 annotated images, reflecting realistic trade-offs between clinical effort and resource constraints for annotations. Our results confirm that generative pre-training enables the model to learn a robust representation. This improves both accuracy and uncertainty on the downstream tasks, advancing towards safe and efficient clinical deployment.

Analyzing microstructural defects in transmission electron microscopy (TEM) images, particularly in irradiated metal alloys, is often limited by the availability of high-quality, labeled data. To address this, we introduce a generative data augmentation approach using a mask-conditioned latent diffusion model (LDM) for synthesizing realistic TEM images with controllable, automatically labeled multi-class defect masks. Without requiring manual annotations for generation, our method enables the creation of synthetic image-mask pairs by sampling distributions learned from experimental masks. These generated data were used to augment small experimental datasets of varying sizes (10, 50, and 100 labeled experimental images) to train a Mask Regional Convolutional Neural Network (R-CNN) model for defect detection and classification. Our results show that generative augmentation yields small overall model performance improvements, with up to a 0.02 gain in the harmonic mean of detection and classification F1 scores. However, we also find that the relative contributions to detection and classification improvement depend on the specific train/test data split. These findings highlight the potential of targeted generative models to enhance deep learning performance in data-scarce microscopy-based image quantification tasks.

Cross-modal 2D-3D gait recognition is impeded by inherent domain discrepancies between 2D silhouette and 3D LiDAR range-view representations. While prior methods align only final embeddings, we propose DiffCrossGait, which reformulates cross-modal matching as trajectory-level alignment in an identity-relevant latent diffusion space, rather than assuming full equivalence between 2D and 3D observations. By driving both modalities with shared Gaussian noise within a latent space, we enable continuous alignment throughout the generative evolution. We introduce a Tri-Phase Alignment Strategy that exploits varying noise intensities to enforce identity anchoring, dynamics consistency, and cross-modal structural recoverability, thereby constraining both modalities to share denoising dynamics and bottleneck structure, which promotes modality-invariant gait features. Crucially, our framework decouples generative alignment from the discriminative backbone; the diffusion mechanism serves exclusively as a training objective, ensuring high inference efficiency by eliminating the computational overhead of iterative denoising. Extensive experiments on the SUSTech1K and FreeGait benchmarks demonstrate that DiffCrossGait achieves state-of-the-art performance.

While automated diagnosis systems have achieved remarkable success in computed tomography (CT)-based lung cancer screening, their development remains limited by the scarcity of diverse, annotated pulmonary nodule datasets. Diffusion-based generative models offer a promising strategy for data synthesis; however, many existing conditional approaches primarily optimize spatial reconstruction losses, which encourage voxel-wise similarity but may inadequately constrain lesion-level intensity distributions. As a result, these methods may produce over-smoothed texture profiles and underrepresent the distinct attenuation characteristics of different nodule subtypes, including solid, part-solid, and ground-glass nodules. To address this challenge, we propose a controllable latent diffusion model that synthesizes pulmonary nodules within full 3D CT volumes while accurately modeling nodule-specific intensity distributions. Specifically, rather than relying solely on spatial losses, we introduce a histogram-based regularization term that constrains voxel intensity distributions during the generative process. The model combines subtype, spatial mask, and Hounsfield unit (HU) histogram conditioning with the differentiable feature-space histogram regularization term to better align lesion-level intensity distributions, improving the visual plausibility and subtype consistency of synthesized nodules. Extensive experiments on lung CT data demonstrate that our framework achieves strong visual realism, validated through both quantitative metrics and a visual Turing test. Furthermore, when used for data augmentation, the generated nodules improve performance in downstream clinical tasks, particularly for underrepresented nodule subtypes, and show a potential benefit for subtype-informed malignancy classification.

Energetic-materials performance gains translate directly into reduced propellant mass, smaller warheads, and more efficient civilian gas-generators, yet no new HMX-class compound has been disclosed in fifteen years. Designing one is a sparse-label problem: of ~66 k labelled CHNO molecules only ~3 k carry experimental or DFT-quality measurements, and naive generative models trained on the full mixture either memorise the high-performance tail or extrapolate without calibration. We introduce Domain-Gated Latent Diffusion (DGLD): a label-quality gate at training time, multi-task score-model guidance at sample time, and a four-stage chemistry-validation funnel ending in first-principles DFT audit. The result is 12 DFT-confirmed novel leads. The headline compound, 3,4,5-trinitro-1,2-isoxazole (L1), reaches \r{ho}"cal" =2.09 g/cm3 and D"K-J,cal" =8.25 km/s and is structurally dissimilar from all 65 980 training molecules (nearest-neighbour Tanimoto 0.27). A co-headline lead, E1 (4-nitro-1,2,3,5-oxatriazole), exceeds L1 on calibrated detonation velocity (D_"K-J,cal" =9.00 km/s) from a chemotype family disjoint from L1's. DGLD is the only method to land in the productive quadrant (simultaneously novel and on-target) at DFT level. SMILES-LSTM memorises 18.3% of its outputs exactly; SELFIES-GA's best novel candidate loses 3.5 km/s under DFT audit; REINVENT 4 generates novel high-N heterocycles but peaks at D=9.02 km/s. Code, checkpoints, and 918 mined hard negatives are released on Zenodo (DOI 10.5281/zenodo.19821953); the next compound to enter the HMX-class band can be discovered, validated, and recommended for synthesis at the cost of a few GPU-days.

Identity-conditioned diffusion models enable high-quality and identity-consistent face generation, but they also raise severe privacy concerns, as models may continue to synthesize individuals despite their right to be forgotten. While machine unlearning has been extensively studied for concept and data removal, identity unlearning remains largely unexplored, particularly in models conditioned directly on identity embeddings rather than text prompts. In this work, we study identity unlearning in Arc2Face, a state-of-the-art identity-conditioned latent diffusion model for face generation, and introduce Proximity-guided Identity Unlearning (PIU), an anchor-guided framework for identity unlearning. Specifically, we formulate identity removal as an identity replacement objective that reassigns the source identity to a selected anchor identity in the learned identity space, and we complement it with a proximity-based anchor selection strategy motivated by the geometry of ArcFace representations. We further show that effective unlearning can be achieved through localized fine-tuning of a small subset of identity-sensitive cross-attention layers. Experiments across multiple target identities show that our framework effectively suppresses generation of the target identity while preserving realism and identity consistency for retained identities, as validated by improved performance on unlearning and image-quality metrics, together with qualitative evaluation. The source code for the PIU identity unlearning framework is made publicly available at https://github.com/edgarcancinoe/piu-unlearning.

Current personalization methods for generative vision models typically encode new concepts through continuous adapters or weight updates, yet provide limited control over whether and when a concept should be retrieved. In this work, we introduce Tiny-Engram, a compact trigger-indexed concept table that gives visual memories an explicit lexical address and activation boundary inside frozen image and video generators. Tiny-Engram parameterizes each concept as a small set of memory entries indexed by registered n-gram matches, which modulate text-encoder hidden states only within the matched trigger region. Outside this lexical support, the conditioning pathway is identical to that of the frozen base model. Across both single-encoder latent diffusion and multi-encoder diffusion-transformer backbones, this formulation binds a rare trigger phrase to a target identity while preserving compositional control from the surrounding prompt. We further evaluate the same table-based memory in a text-conditioned video generation setting, where the trigger path reliably alters the generated subject but fine-grained identity persistence across held-out video prompts remains limited. Taken together, these results suggest that small, explicitly addressed concept tables are a practical route to modular visual personalization, with strongest evidence in image generation. For video diffusion, the remaining gap points to a broader requirement: temporally stable identity likely depends on tighter coupling between text-side memory and the evolving visual state, motivating future work on memory injection beyond the text-conditioning interface.

Irregular multivariate time series impose a trade-off for long-horizon forecasting: discrete methods can distort temporal structure via re-gridding, while continuous-time models often require sequential solvers prone to drift. To bridge this gap, we present Latent Laplace Diffusion (LLapDiff), a generative framework that models the target as a low-dimensional latent trajectory, enabling horizon-wide generation without step-by-step integration over physical time. We guide the reverse process utilizing a stable modal parameterization motivated by stochastic port-Hamiltonian dynamics, and parameterize its mean evolution in the Laplace domain via learnable complex-conjugate poles, enabling direct evaluation over irregular timestamps. We also link continuous dynamics to irregular observations through renewal-averaging analysis, which maps sampling gaps to effective event-domain poles and motivates a gap-aware history summarizer. Extensive experiments show that LLapDiff improves over baselines in long-horizon forecasting, and its continuous-time generative nature supports missing-value imputation by querying the same model at historical timestamps. Code is available at https://github.com/pixelhero98/LLapDiffusion.

Hexahedral meshes are widely used in simulation pipelines, yet automatic generation remains challenging for complex CAD geometries. Polycube-based hexahedral meshing is a representative approach due to its regular, parameterization-friendly structure, but existing polycube construction methods often rely on intricate surface segmentation and local heuristics, which can produce artifacts or fail on difficult shapes. In this paper, we propose an end-to-end framework for polycube generation based on conditional diffusion models. Given an input geometry represented as a point cloud, our method directly produces a corresponding polycube point cloud, eliminating the need for explicit surface segmentation or predefined polycube templates. At the core of our approach is a dual-latent conditional diffusion architecture that confines computationally expensive self-attention operations to a fixed-capacity, low-dimensional latent space. This design effectively decouples computational complexity from the resolution of both the input geometry and the output polycube, thereby avoiding the quadratic cost typical of point cloud self-attention mechanisms while supporting flexible input and output resolutions. To obtain a hexahedral mesh, the generated polycube is aligned to the input shape via rigid and non-rigid point cloud registration to establish surface correspondence, followed by a polycube-to-hex pipeline. We additionally create and release a paired dataset of CAD meshes and their corresponding polycube meshes, together with the core implementation of our model. Experiments show that PolycubeNet generalizes to complex CAD models with arbitrary genus and produces high-quality polycube structures within seconds, improving robustness and efficiency over prior learning-based approaches.

Face inpainting techniques recover missing or occluded facial regions in a visually realistic manner, but preserving the identity in the final output remains a fundamental challenge. Identity consistency is crucial for downstream applications such as face recognition, digital forensics, and human-computer interaction, where even subtle identity distortions can significantly degrade performance or trust. Although diffusion-based generative models have recently achieved remarkable progress in image inpainting, they often struggle to faithfully retain individual-specific facial characteristics. On the other hand, existing identity-aware methods typically rely on costly fine-tuning, auxiliary supervision, or exhibit limited robustness to diverse occlusions, poses, and facial variations. To address these limitations, we propose ID-ControlNet, an identity-preserving face inpainting framework built upon latent diffusion models. Based on ControlNet architecture, our approach conditions the diffusion process on facial identity embeddings extracted from a pretrained face recognition network. This design enables reconstruction of occluded facial regions while maintaining global facial coherence and identity fidelity. Furthermore, we introduce an identity consistency and triplet loss training strategy that explicitly enforces alignment between the generated face and the target identity representation. Extensive experiments on CelebA-HQ, FFHQ, and on a new E-Mask dataset demonstrate that ID-ControlNet significantly improves identity preservation over standard diffusion-based inpainting methods, achieving performance comparable to SOTA identity-aware approaches.

Modern deep learning models for change detection (CD) often struggle to explicitly represent task-relevant semantic differences. This paper proposes the Latent Difference Guidance (LDGuid) framework that explicitly learns and injects semantic differences into CD models. LDGuid deploys adversarial autoencoding to implement a difference embedding (DE) module. The DE module is pretrained via the information bottleneck method, restricting it to learn only task-relevant differences between pre- and post-event samples. The learned latent difference is then used as an explicit guidance signal in the CD model. We validate LDGuid by integrating it into U-Net, BIT, and AERNet baselines for CD and evaluating it on LEVIR-CD, WHU-CD, SVCD, and CaBuAr datasets. Experimental results show that LDGuid enhances segmentation performance across all benchmarks, with particularly remarkable gains in challenging settings affected by spectral noise. The results further highlight the ability of LDGuid in incorporating domain knowledge, such as task-specific spectral indices. Our findings suggest that semantic difference learning can drastically enhance the robustness of CD in remote sensing.

Symbolic-control drum generation requires preserving explicit event timing and dynamics while synthesizing acoustically plausible waveforms. We present Sec2Drum-DAC, a conditional latent-diffusion model for symbolic-to-audio drum rendering. The model conditions on event features sampled in physical time at codec-frame locations and predicts standardized principal-component coordinates of frozen DAC summed-codebook embeddings rather than waveform samples. In the evaluated DAC configuration, 72 principal components capture the observed training-frame summed-latent subspace under the stated SVD threshold, yielding a compact continuous denoising target with a deterministic reconstruction path to the 1024-dimensional DAC latent space before waveform decoding. Across 1,733 held-out four-beat windows, PCA diffusion improves paired spectral and transient metrics over deterministic PCA regression and a symbolic rendering baseline, while direct regression remains stronger on phase-sensitive waveform L1. Auxiliary RVQ cross-entropy improves short-step diffusion on mel error, onset-flux cosine, and waveform L1, with the most favorable trade-offs occurring at 6-25 denoising steps depending on the metric.

Diffusion Transformers (DiT) trained with flow matching in a VAE latent space have unified visual generation across images and videos. A natural next step toward a single architecture for both generation (visual synthesis) and understanding (text generation) is to apply this framework to language modeling. We propose TextLDM, which transfers the visual latent diffusion recipe to text generation with minimal architectural modification. A Transformer-based VAE maps discrete tokens to continuous latents, enhanced by Representation Alignment (REPA) with a frozen pretrained language model to produce representations effective for conditional denoising. A standard DiT then performs flow matching in this latent space, identical in architecture to its visual counterpart. The central challenge we address is obtaining high-quality continuous text representations: we find that reconstruction fidelity alone is insufficient, and that aligning latent features with a pretrained language model via REPA is critical for downstream generation quality. Trained from scratch on OpenWebText2, TextLDM substantially outperforms prior diffusion language models and matches GPT-2 under the same settings. Our results establish that the visual DiT recipe transfers effectively to language, taking a concrete step toward unified diffusion architectures for multimodal generation and understanding.

World model-based policy evaluation is a practical proxy for testing real-world robot control by rolling out candidate actions in action-conditioned video diffusion models. As these models increasingly adopt latent diffusion modeling (LDM), choosing the right latent space becomes critical. While the status quo uses autoencoding latent spaces like VAEs that are primarily trained for pixel reconstruction, recent work suggests benefits from pretrained encoders with representation-aligned semantic latent spaces. We systematically evaluate these latent spaces for action-conditioned LDM by comparing six reconstruction and semantic encoders to train world model variants under a fixed protocol on BridgeV2 dataset, and show effective world model training in high-dimensional representation spaces with and without dimension compression. We then propose three axes to assess robotic world model performance: visual fidelity, planning and downstream policy performance, and latent representation quality. Our results show visual fidelity alone is insufficient for world model selection. While reconstruction encoders like VAE and Cosmos achieve strong pixel-level scores, semantic encoders such as V-JEPA 2.1 (strongest overall on policy), Web-DINO, and SigLIP 2 generally excel across the other two axes at all model scales. Our study advocates semantic latent space as stronger foundation for policy-relevant robotics diffusion world models.

As a key technique in multi-modal processing, infrared and visible image fusion (IVIF) plays a crucial role in integrating complementary spectral information for visual enhancement and downstream vision tasks. Despite remarkable progress, existing methods struggle to flexibly accommodate heterogeneous demands. Achieving adaptive fusion that aligns with various preferences from both human and machine vision remains an open and challenging problem. To address this challenge, we propose DPOFusion, a direct preference optimization (DPO) framework integrating the property-aligned latent diffusion model (PALDM) and the preference-controllable latent diffusion model (PCLDM), enabling task-guided, preference-adaptive IVIF for both human and machine vision. The PALDM leverages a latent fusion prior and a joint conditional loss to generate diverse candidate fusion results with various properties. PCLDM is subsequently fine-tuned via instance direct preference optimization (IDPO), enabling direct control of the final fusion results with heterogeneous preference signals. Experimental results demonstrate that our framework not only attains precise preference alignment among humans, vision-language models, and task-driven networks, but also sets a new benchmark for adaptive fusion quality and task-oriented transferability.

Diffusion models have recently demonstrated strong performance for image restoration tasks, including super-resolution. However, their large model size and iterative sampling procedures make them computationally expensive for practical deployment. In this work, we present TOC-SR, a framework for building efficient one-step super-resolution models by first discovering a compact diffusion backbone. Starting from a sixteen-channel latent diffusion model, we construct parameter-efficient surrogate blocks using feature-wise generative distillation and perform architecture discovery using epsilon-constrained Bayesian Optimization to minimize model complexity while preserving generative fidelity. The resulting compact diffusion backbone achieves a 6.6x reduction in parameters and a 2.8x reduction in GMACs compared to the expanded diffusion model. We then adapt this backbone for super-resolution and distill the diffusion process into a single-step generator. Experiments demonstrate that the proposed approach enables efficient super-resolution while maintaining strong reconstruction quality.

Suspect face generation remains a technical challenge in crime investigations. Traditional sketch-drawing workflows suffer from low efficiency and quality, while diffusion-based approaches still face intrinsic limitations on conditional ambiguity for text-to-image models and sampling variance for one-shot generation. We proposed IdentiFace, a novel diffusion-based framework for identifiable suspect face generation, which addressed these issues through (1) multi-modal input design to strengthen conditional control, and (2) an iterative generation pipeline enabling identifiable feature adjustment. We additionally contributed a facial identity loss and two task-specific datasets. Comprehensive experiments on synthetic datasets and in real-world scenarios indicate that IdentiFace achieves superior performance over existing methods, especially in terms of identity retrieval, and shows strong potential for practical applications.

Robust in-bed human pose estimation under blanket occlusion remains challenging due to the scarcity of reliable labeled training data for heavily covered poses. Existing approaches rely on multi-modal sensing or image-to-image translation frameworks that remain conditioned on visible source imagery, limiting scalability and pose diversity. In this work, we reformulate occlusion-aware augmentation as a geometry-conditioned generative modeling task. We conduct a systematic comparison of deterministic masking, unpaired translation, paired diffusion-based translation, and a proposed pose-conditioned Latent Diffusion Model (Pose-LDM). Unlike image-guided methods, Pose-LDM synthesizes blanket-covered images directly from skeletal keypoints, eliminating dependence on paired supervision and pixel-level source-image conditioning while enabling generation from arbitrary pose inputs. All augmentation strategies are evaluated through their impact on downstream pose estimation under a fixed backbone. Pose- LDM achieves the highest strict localization accuracy under severe occlusion while maintaining overall detection performance comparable to paired diffusion models, approaching the performance of fully supervised training. These results demonstrate that geometry-conditioned diffusion provides an effective and supervision-efficient pathway toward occlusion-robust inbed pose estimation without modifying the sensing pipeline. The code is available at: github.com/navidTerraNova/ GeoDiffPose.

Advancing face morphing attack techniques is crucial to anticipate evolving threats and develop robust defensive mechanisms for identity verification systems. This work introduces DCMorph, a dual-stream diffusion-based morphing framework that simultaneously operates at both identity conditioning and latent space levels. Unlike image-level methods suffering from blending artifacts or GAN-based approaches with limited reconstruction fidelity, DCMorph leverages identity-conditioned latent diffusion models through two mechanisms: (1) decoupled cross-attention interpolation that injects identity-specific features from both source faces into the denoising process, enabling explicit dual-identity conditioning absent in existing diffusion-based methods, and (2) DDIM inversion with spherical interpolation between inverted latent representations from both source faces, providing geometrically consistent initial latent representation that preserves structural attributes. Vulnerability analyses across four state-of-the-art face recognition systems demonstrate that DCMorph achieves the highest attack success rates compared to existing methods at both operational thresholds, while remaining challenging to detect by current morphing attack detection solutions.

Latent diffusion models have emerged as powerful generative models in medical imaging, enabling the synthesis of high quality brain magnetic resonance imaging scans. In particular, predicting the evolution of a patients brain can aid in early intervention, prognosis, and treatment planning. In this study, we introduce CLIMB, Controllable Longitudinal brain Image generation via state space based latent diffusion model, an advanced framework for modeling temporal changes in brain structure. CLIMB is designed to model the structural evolution of the brain structure over time, utilizing a baseline MRI scan and its acquisition age as foundational inputs. Additionally, multiple conditional variables, including projected age, gender, disease status, genetic information, and brain structure volumes, are incorporated to enhance the temporal modeling of anatomical changes. Unlike existing LDM methods that rely on self attention modules, which effectively capture contextual information from input images but are computationally expensive, our approach leverages state space, a state space model architecture that substantially reduces computational overhead while preserving high-quality image synthesis. Furthermore, we introduce a Gaussian-aligned autoencoder that extracts latent representations conforming to prior distributions without the sampling noise inherent in conventional variational autoencoders. We train and evaluate our proposed model on the Alzheimers Disease Neuroimaging Initiative dataset, consisting of 6,306 MRI scans from 1,390 participants. By comparing generated images with real MRI scans, CLIMB achieves a structural similarity index of 0.9433, demonstrating notable improvements over existing methods.

Accurately modeling longitudinal brain MRI progression is crucial for understanding neurodegenerative diseases and predicting individualized structural changes. Existing state-of-the-art approaches, such as Brain Latent Progression (BrLP), often use multi-stage training pipelines with auxiliary conditioning modules but suffer from architectural complexity, suboptimal use of conditional clinical covariates, and limited guarantees of anatomical consistency. We propose Anatomically Guided Latent Diffusion Model (AG-LDM), a segmentation-guided framework that enforces anatomically consistent progression while substantially simplifying the training pipeline. AG-LDM conditions latent diffusion by directly fusing baseline anatomy, noisy follow-up states, and clinical covariates at the input level, a strategy that avoids auxiliary control networks by learning a unified, end-to-end model that represents both anatomy and progression. A lightweight 3D tissue segmentation model (WarpSeg) provides explicit anatomical supervision during both autoencoder fine-tuning and diffusion model training, ensuring consistent brain tissue boundaries and morphometric fidelity. Experiments on 31,713 ADNI longitudinal pairs and zero-shot evaluation on OASIS-3 demonstrate that AG-LDM matches or surpasses more complex diffusion models, achieving highly competitive image quality and 15-20% reduction in volumetric errors in generated images. AG-LDM also exhibits markedly stronger utilization of temporal and clinical covariates (3.5-31.5x higher covariate sensitivity than BrLP) and generates biologically plausible counterfactual trajectories, accurately capturing hallmarks of Alzheimer's progression such as limbic atrophy and ventricular expansion. These results highlight AG-LDM as an efficient, anatomically grounded framework for reliable brain MRI progression modeling.

Medical image segmentation is crucial for clinical diagnosis and treatment planning. Traditional methods typically produce a single segmentation mask, failing to capture inherent uncertainty. Recent generative models enable the creation of multiple plausible masks per image, mimicking the collaborative interpretation of several clinicians. However, these approaches remain computationally heavy. We propose MedSegLatDiff, a diffusion based framework that combines a variational autoencoder (VAE) with a latent diffusion model for efficient medical image segmentation. The VAE compresses the input into a low dimensional latent space, reducing noise and accelerating training, while the diffusion process operates directly in this compact representation. We further replace the conventional MSE loss with weighted cross entropy in the VAE mask reconstruction path to better preserve tiny structures such as small nodules. MedSegLatDiff is evaluated on ISIC-2018 (skin lesions), CVC-Clinic (polyps), and LIDC-IDRI (lung nodules). It achieves state of the art or highly competitive Dice and IoU scores while simultaneously generating diverse segmentation hypotheses and confidence maps. This provides enhanced interpretability and reliability compared to deterministic baselines, making the model particularly suitable for clinical deployment.

Generative modeling frameworks have emerged as an effective approach to capture high-dimensional image distributions from large datasets without requiring domain-specific knowledge, a capability essential for disease progression modeling. Recent generative approaches have attempted to capture progression by mapping images to a latent space and guiding representations to generate follow-up images from previous time points. However, these methods impose constraints on distribution learning, resulting in latent spaces with limited controllability for generating follow-up images without paired subject-specific longitudinal guidance. In order to enable controlled movements in the latent representational space and generate progression images from a previous time-point image without subject-specific guidance, we introduce a conditionable Diffusion Auto-encoder framework that forms a compact latent space capturing high-level semantics and providing means to control generation. Our approach leverages this latent space to condition and apply controlled shifts to the representations of previous time-point images by isolating progression and subject identity information for generating follow-up images. The shifts are implicitly guided by correlating with progression attributes and constraining to Alzheimer's disease specific regions, without paired longitudinal guidance. We validate the generations through image quality metrics, volumetric progression analysis, and downstream tasks in Alzheimer's disease datasets from different sources. This demonstrates the effectiveness of our approach for Alzheimer's progression modeling and longitudinal image generation.

License plate image restoration is important not only as a preprocessing step for license plate recognition but also for enhancing evidential value, improving visual clarity, and enabling broader reuse of license plate images. We propose a novel diffusion-based framework with character-level guidance, CharDiff-LP, which effectively restores and recognizes severely degraded license plate images captured under realistic conditions. CharDiff-LP leverages fine-grained character-level priors extracted through external segmentation and Optical Character Recognition (OCR) modules tailored for low-quality license plate images. For precise and focused guidance, CharDiff-LP incorporates a novel Character-guided Attention through Region-wise Masking (CHARM) module, which ensures that each character's guidance is restricted to its own region, thereby avoiding interference with other regions. In experiments, CharDiff-LP significantly outperformed baseline restoration models in both restoration quality and recognition accuracy, achieving a 28.3% relative reduction in character error rate (CER) on the Roboflow-LP dataset compared with the best-performing baseline.

Latent Diffusion Models have shown remarkable results in text-guided image synthesis in recent years. In the domain of natural (RGB) images, recent works have shown that such models can be adapted to various vision-language downstream tasks with little to no supervision involved. On the contrary, text-to-image Latent Diffusion Models remain relatively underexplored in the field of medical imaging, primarily due to limited data availability (e.g., due to privacy concerns). In this work, focusing on the chest X-ray modality, we first demonstrate that a standard text-conditioned Latent Diffusion Model has not learned to align clinically relevant information in free-text radiology reports with the corresponding areas of the given scan. Then, to alleviate this issue, we propose a fine-tuning framework to improve multi-modal alignment in a pre-trained model such that it can be efficiently repurposed for downstream tasks such as phrase grounding. Our method sets a new state-of-the-art on a standard benchmark dataset (MS-CXR), while also exhibiting robust performance on out-of-distribution data (VinDr-CXR). We further validate our approach through a pilot qualitative study and an experiment on grounded disease classification. Our code will be made publicly available at https://github.com/vios-s.

Generating semantically controllable 3D CT volumes from radiology reports requires more than a rich text encoder, it requires vision-language alignment grounded in volumetric space. Existing Text-to-CT approaches condition generation on encoders pretrained with language only or 2D vision-language objectives, providing conditioning signals that are linguistically expressive but volumetrically blind. We argue this is a structural limitation: the quality of 3D vision-language alignment, not the richness of the text encoder, is the primary bottleneck for semantic controllability in volumetric diffusion models. To address this, we propose a generation-oriented 3D-CLIP encoder trained with structured hard negatives that operate exclusively at the text level. This design increases contrastive difficulty without any additional 3D memory cost, overcoming the small-batch constraints inherent to volumetric encoders. The resulting encoder conditions a fully end-to-end latent diffusion model that operates directly in 3D latent space, eliminating the spatial artifacts and cross-slice inconsistencies introduced by super-resolution pipelines. Through systematic ablations, we establish a clear empirical link between grounding quality and downstream generative controllability. Evaluated on CT-RATE across 18 pathological conditions, our method achieves state-of-the-art performance on both image fidelity and factual correctness, while requiring less inference time and GPU memory than all competing methods. Code is at https://github.com/danielemolino/Text2CT.

Automotive radar has shown promising developments in environment perception due to its cost-effectiveness and robustness in adverse weather conditions. However, the limited availability of annotated radar data poses a significant challenge for advancing radar-based perception systems. To address this limitation, we propose a novel framework to generate 4D radar point clouds for training and evaluating object detectors. Unlike image-based diffusion, our method is designed to consider the sparsity and unique characteristics of radar point clouds by applying diffusion to a latent point cloud representation. Within this latent space, generation is controlled via conditioning at either the object or scene level. The proposed 4D-RaDiff converts unlabeled bounding boxes into high-quality radar annotations and transforms existing LiDAR point cloud data into realistic radar scenes. Experiments demonstrate that incorporating synthetic radar data of 4D-RaDiff as data augmentation method during training of object detection models consistently improves performance compared to training on real data only. In addition, pre-training on our synthetic radar data achieves competitive detection performance, providing a promising, scalable approach to reduce dependence on costly manual annotations.