Risk
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17 papers in the last four weeks, up 55% on the four weeks before. 0.2% of all new papers.
Latest papers 129
Explainable suicide-risk assessment requires models not only to estimate risk severity, but also to identify supporting language and the risk and protective factors expressed in a post. We present our system for the IEEE BigData 2026 Cup on Explainable Suicide Risk Assessment on Social Media, which addresses three tasks: risk-level classification, evidence phrase extraction, and multi-label factor identification. Our approach adapts Qwen2.5-Instruct models using quantized low-rank adaptation (QLoRA) and an answer-masked causal language-model objective. We jointly train across all three tasks for risk classification, jointly train on Tasks1a and 1b for evidence extraction, and adapt Task2 separately for factor identification. We also tailor aggregation to each output: we average risk-level probabilities from the 32B and 72B models, combine evidence phrases through cross-fold consensus, and calibrate factor-specific decisions through rate matching based on out-of-fold operating points. On the official leaderboard, the final system achieved a composite score of 0.7738, with 0.8089 on Task1 and 0.6919 on Task2. Across the evaluated configurations, three-task training performed best for Task1a, joint training on Tasks1a and 1b performed best for Task1b, and task-specific training performed best for Task2. Probability averaging further improved Task~1a when component models had complementary errors. These findings highlight the value of tailoring both training objectives and aggregation strategies to the output structure of each task within a unified language-model framework.
Caption-Mediated Perceived-Safety Estimation for Pedestrian Routing
This paper presents an explainable approach to pedestrian routing, in which perceived safety is estimated from street-level imagery through an explicit natural-language intermediate representation. A vision--language model caption is generated and stored before any scoring is undertaken, and the perceived-risk class is derived entirely from structured features of that stored text, so that every segment score remains inspectable by the user. Nine captioning conditions across five model families are benchmarked against a direct Contrastive Language--Image Pre-training (CLIP) image-embedding baseline under an identical downstream pipeline, and the caption-mediated representation is found to reach parity with the image embedding rather than to trail it. The approach was deployed over 654,115 images covering 36 electoral wards in two locations in Northern England (Manchester and Huddersfield). Independent field validation against 3,669 locally collected ratings of 494 images across 70 participant sessions established agreement that is statistically significant but modest, at , against a measured noise ceiling of 0.737 imposed by disagreement between raters. A single-use confirmatory test then found that a pipeline 44% stronger on the supervised benchmark did not produce measurable improvement in the field (, ), so the benchmark gains did not predict the deployment gains in this case. Routing behaviour varies systematically with journey length. There is negligible change below 1,km, reaching a median increase of 12.78% in low-risk route length for a median detour of 2.73% on journeys of 3 to 6 km.
Mixed-Prior Decision Risk for Open-Set Recognition
In open-set recognition (OSR), a probe must either be identified as one of the known gallery classes or rejected as unknown, so three error types coexist: false acceptance, false rejection, and misidentification. An uncertainty score for selective recognition should rank probes by the risk of the decision the system has made. Bayesian gallery-aware models such as Holistic Uncertainty Estimation (HolUE) summarize the posterior over known and unknown classes by Kullback--Leibler (KL) divergence components and map them to an uncertainty score with a supervised nonlinear calibrator. We show that the KL summary is not generally monotone in decision risk: linear fusion of the KL components tuned on validation data yields negative filtering quality on several benchmarks. We propose MPRisk, a mixed-prior posterior decision-risk score that keeps the same Bayesian posterior but directly scores the error events associated with the selected decision: false-acceptance, misidentification, and false-rejection risks, plus a non-specificity penalty for rejections, enabled by modeling unknown identities as a continuous component. Four nonnegative weights tuned on a validation set suffice for ranking; no nonlinear supervised model is required. Across nine image, audio, and text benchmarks, MPRisk achieves the best or tied-best Prediction Rejection Ratio at every operating point on the image and audio benchmarks and on most text operating points, with bootstrap-confirmed gains over HolUE on five benchmarks (up to PRR) at comparable or lower runtime.
Still There, No Longer Seen: Exposing Compression-Induced Risk in Large Vision-Language Models
Visual token compression reduces the inference cost of Large Vision-Language Models (LVLMs). However, aggregate robustness measures do not reveal whether a particular adversarial failure is induced by compression or inherited from the underlying model. We define a compression-specific failure (CSF) as an adversarial input that remains correct under full-token inference but fails after compression, casting compression-induced risk as a paired failure attribution problem. Within a controlled diagnostic cohort, counterfactuals show that retained-set allocation causally changes compressed correctness and reveal a negative association between recovery and representation drift in displaced evidence. Motivated by these findings, we propose CIRA, a Compression-Induced Risk Attack for Large Vision-Language Models. Under a vision-encoder white-box setting, CIRA optimizes image perturbations through encoder-side objectives that manipulate token priorities across candidate compression budgets while preserving displaced evidence. CIRA uses no downstream questions or labels and requires no access to the language model, deployed compressor, or exact compression budget. Across 12 dataset-compressor settings evaluated at four budgets, CIRA achieves a mean CSFR of 20.35% while limiting full-token attack success to 6.92%, with similar behavior on additional LVLM families. A cross-view selection-stabilization defense substantially suppresses CIRA, although Adaptive CIRA partially restores its effectiveness. These results show that compression-specific failures persist under restricted access and support paired evaluation of full-token and compressed inference for attributing risk to visual-token compression.
Unknown is not normal: separating language-model extraction from rule-based decision logic for clinical risk scores
Large language models (LLMs) are increasingly used to compute clinical risk scores from free-text notes. Notes are often incomplete, and treating undocumented findings as normal can silently misclassify patients. We test whether separating three-state extraction (present, absent or unknown, by an LLM) from decision logic (deterministic code computing score bounds over unknown inputs) lets a system ask only questions that can change the decision. On 1,200 synthetic emergency cases across six calculators (HEART, CURB-65, qSOFA, PERC, Wells, Cockcroft-Gault), with a simulated clinician answering questions, we compared this bounds policy with asking for every missing input, a missing-equals-normal schema, and an end-to-end LLM agent (Claude Opus 5.5). With Claude Haiku 4.5 as extractor, the bounds policy matched ask-all accuracy (99.4% vs 99.4%) with half the questions (0.92 vs 1.78 per case) and no irrelevant ones. Treating missing as normal dropped accuracy to 91.2% and under-triaged 8.5% of patients (95% CI 7.1-10.2), and under-triage persisted under messy notes and a noisy clinician. The agent was equally accurate under ideal conditions (99.6%) but 9.5% of its questions were irrelevant; with a noisy clinician it was less accurate than the bounds policy (83.5% vs 87.0%, p<0.001) and committed prematurely in 2.7% of cases (bounds: 0%). A 9B local model as extractor reached oracle-level accuracy (99.8%). In 584 real case reports from MedCalc-Bench, only 52% contained enough information to determine the category (HEART 13%). Routing decisions through code that reasons explicitly about unknowns avoids premature commitment and irrelevant questions, halves the questions asked, and works with small local models.
Learning Risk Scores Robust to Unobserved Confounders
We consider the problem of learning risk scores to prioritize individuals for scarce resources or interventions, from historical observational data affected by unobserved confounding. Decisions about who receives scarce resources are often guided by risk scores based on recorded characteristics, such as responses to a survey. These risk scores are increasingly being learned directly from observational data: historical records of individuals' characteristics, allocation decisions, and outcomes. Standard methods such as inverse propensity weighting (IPW), which corrects for the bias introduced by the historical allocation policy, can be used to learn accurate risk scores if the historical decision process is fully explained by the recorded characteristics. In practice, however, historical decisions often depend on unrecorded information, causing learned risk scores to systematically under-prioritize exactly the individuals whose unrecorded circumstances drove past prioritization. We propose a method for learning risk scores that are robust to this kind of unobserved confounding, building on IPW. Since propensity weights cannot be reliably estimated under unobserved confounding, we instead treat them as belonging to an uncertainty set determined by the observable data and domain-informed estimates of the degree of confounding, combining sensitivity analysis from causal inference with Wasserstein distributionally robust optimization. The resulting robust risk score learning problem admits a sample-based approximation that we reformulate as an exponential cone program compatible with off-the-shelf solvers. We demonstrate the effectiveness of our approach on semi-synthetic data derived from datasets in the UCI Machine Learning Repository. Our method improves calibration by up to 29.2% over traditional benchmarks and up to 11.1% over the state of the art, without compromising other metrics.
Misaligned Clinical Risk Classification and Cost Asymmetry in Open-Weight Large Language Models
How large language models (LLMs) integrate patient risk with clinical cost tradeoffs remains poorly understood. We investigated how four open-weight LLMs (Qwen-2.5-7B/32B and Llama-3.1-8B/70B) internally represent cost tradeoffs, how these representations relate to clinical predictions, and whether decisions shift as predicted by the specified cost direction and magnitude. Using a public diabetes dataset, we varied 11 false-negative (FN) to false-positive (FP) cost ratios across three phrasings and examined representations and behavioral outputs. Patient risk was linearly recoverable on par with conventional classifiers (AUC ), and cost direction was recoverable in every model. However, representational shifts in cost direction tracked output changes only in the two larger models, and responses to cost magnitude were predominantly direction-agnostic. Only 2 of 12 model-phrasings showed both opposing responses to increasing FN versus FP costs and cost-correct ordering. Representationally, a direction fitted on one cost side did not invert when transferred to the other, as expected under mirror-symmetric encoding. These findings suggest that LLMs encode risk and cost information but do not reliably integrate them into cost-correct decisions. Clinical evaluations should therefore include tradeoff tests, phrasing sensitivity, and default operating points alongside predictive performance.
Falling Trees: A Model Class for Interpretable Risk Prioritization
Many real-world decisions require prioritizing high-risk cases, such as clinicians prioritizing high-risk patients before lower-risk ones. Falling rule lists (FRLs), which are ordered if--then rules with monotonically decreasing risks, provide an interpretable framework for such tasks; however, their single-path structure yields a highly restricted model class. We introduce falling trees, a new family of interpretable models that enforces the same monotonic risk constraint while permitting tree-structured branching. We present GRAVITree, a novel dynamic-programming-with-bounds algorithm for learning the Rashomon set of falling trees under depth and branching constraints. Our formulation can interpolate between rule lists and full decision trees, enabling user-desired model expressivity. In a new clinical dataset and in many public classification benchmarks, falling trees match or outperform FRLs and other interpretable baselines, often producing more sparse decisions for high-risk instances. Our results show that falling trees strike a practical balance between interpretability, expressiveness, and risk prioritization for high-stakes settings.
When Should LLMs Abstain? Chain-of-Self-Questioning for Selective Risk Control
Large language models can produce fluent answers when their factual support is weak. This paper introduces Chain-of-Self-Questioning (CoSQ), a prompt-only framework that makes answer commitment conditional on an explicit assessment of the information required to answer a question. We evaluate three CoSQ variants under seventeen conditions on the 817-item TruthfulQA multiple-choice validation set using eleven open-weight and hosted model families. In the final balanced-option protocol, Grounded-CoSQ at τ=0.90 reduces the mean unconditional wrong-commitment rate from 13.1% under chain-of-thought prompting to 8.9%, a 32.1% relative reduction, while increasing answered accuracy from 86.9% to 89.7% and answering 87.6% of questions. Both improvements hold for all eleven models and at every evaluated threshold. Critical-CoSQ and Adaptive-CoSQ provide neighboring operating points with 88.6% and 86.5% coverage, respectively, while remaining more reliable than the baseline. A secondary Natural Questions Short-Answer evaluation provides convergent open-form evidence. These findings show that self-assessment can support explicit, tunable answer-or-abstain decisions when an unsupported commitment is more costly than referral or review.
Memorisation bias in medical AI
Medical AI models hold immense potential to improve patient outcomes, but they are also known to unintentionally memorise individual records from their training datasets. While such memorisation has been linked to targeted privacy attacks, its consequences for clinical deployment, where patients may be assessed by a model that saw their historical data during training, remain poorly understood. Here we show that predictions on a patient's unseen future data can change significantly if a model observed that same patient's anonymised historical data during training, a phenomenon we term "memorisation bias". We demonstrate that this bias exists across diverse data modalities and model architectures, and over prolonged time spans: in some cases, memorisation bias persists on future records acquired decades after the historical records used for training. Moreover, in simulated prospective deployment, memorisation bias has asymmetric effects on the diagnostic accuracy of returning data contributors. When a patient returned with a de novo condition absent from their historical records in the training dataset, diagnostic sensitivity decreased significantly compared to an otherwise identical model not trained on their historical data. Conversely, when their health state was unchanged, both sensitivity and specificity were significantly inflated. Our findings reveal a previously uncharacterised risk in medical AI that arises when a model is deployed on patients who contributed to its training data. This exposes a shortcoming of current model development practice: the de-identification measures designed to protect patients' privacy make it difficult to identify returning contributors and exclude them from the AI-assisted interpretation of their own future data. Mitigating memorisation risks may thus require changes to current model training and deployment protocols.
MemRiskBench: Trace-Aware Risk-Preserving Evaluation for Long-Horizon LLM Agents
Long-horizon LLM agents accumulate memory across sessions, creating sparse but high-impact risks: stale facts, conflicting updates, cross-user leakage, revoked-memory reuse, and constraint decay. Standard aggregate scores hide per-risk failure rates--a model achieving 78% average accuracy may still leak data in 4% of episodes--and benchmark compression preferentially discards the rare high-severity events that distinguish a mostly-working model from one that occasionally causes harm. We present MemRiskBench. The primary contribution is a five-category risk taxonomy (plus one documented, unscored category) operationalized by deterministic trace grounded checks, instantiated as a 120-episode scripted benchmark with full trace logging and no LLM-as-judge on the pass/fail path, evaluated on five locally run quantized instruction-tuned models. Second, a risk-preserving subset selector: a coverage-constrained greedy selector on deterministic trace-derived features that retains full ranking (Spearman rho = 0.975, deterministic; CI collapses to a point estimate with zero bootstrap variance), risk coverage (1.0), and high-risk model detection (1.0) at a 20% subset size, reducing compute 5x. Unlike ranking-only subset selectors, this selector additionally preserves risk-type coverage and high-risk detection using trace-grounded deterministic features that do not require an LLM judge. All episodes, traces, the scoring implementation, and the selector are released to support reproducible evaluation and risk assessment of deployed LLM agents
When Information is Worth the Risk: Behavioral Valuation for Hazardous Robotic Exploration
Hazardous robotic exploration requires robots to map spatial risks, such as unsafe terrain, radiation, fire, mines, or structural damage, while operating where collecting information can itself cause failure. A highly informative path may expose the robot to hazards, terminate execution, and prevent future observations. Hazardous exploration therefore requires deciding not only where uncertainty is largest, but when reducing it is worth the risk. This paper introduces a valuation-layer view of this problem. We keep the belief update, sensor model, physical risk model, and finite-horizon informative planner fixed, and change only the scalar objective used to rank feasible paths. Within this framework, we introduce a risk-augmented Behavioral Information objective based on Prelec probability weighting, yielding an interpretable family of conservative-to-aggressive information-risk valuations. Theoretically, we show that valuation parameters create switching boundaries between high-information/high-risk and lower-information/lower-risk paths, and induce a transformed Pareto-frontier structure over feasible exploration policies. Large-scale failure-truncated grid-world experiments show that valuation alone reshapes the information-risk frontier. Shannon information planning remains a strong raw-information baseline, while risk-aware objectives can reduce hazard exposure and robot losses by avoiding failures that truncate future sensing. Risk-augmented Behavioral valuation is Pareto-competitive with standard risk-aware baselines and provides interpretable conservative and intermediate regimes. These results support a framework in which robots reason not only about how much uncertainty an action reduces, but whether that reduction is worth the risk required to obtain it.
X-amine509: Predicting the Practical Risk Level of Enterprise X.509 Certificates
Enterprises managing large X.509 certificate inventories face a prioritization problem: deterministic analysis tools that precisely identify standards violations are indispensable for remediation, but applying them exhaustively across millions of certificates is operationally impractical. We present X-amine509, a two-stage triage system that uses machine learning to rapidly rank certificates by predicted risk and route only the highest-risk items to full deterministic analysis. Certificate risk is quantified as a composite score derived from 177 defect checks grounded in CA/Browser Forum Baseline Requirements, NIST IR 8547/SP 800-57, and cryptographic strength criteria, weighted by security severity across four tiers ranging from cryptographic breaks to minor compliance deviations. We collected 1,027,714 X.509 certificates from Fortune 500, .gov, and .edu domains and scored each using this rubric. On a held-out test set of 201,976 certificates, our best model (Extra Trees) achieves of 0.993 with MAE of 2.26, while Decision Tree scores of 0.986 at 3.7 million certificates per second on a single machine. Ranking quality confirms the triage value: aggregate NDCG exceeds 0.997, and severity-tier classification reports 99.76% accuracy with 98.90% recall on critical-tier defects. Thirteen months later, we retrieved another 571,374 certificates to test our models' durability over time, and the Extra Trees and Decision Tree models maintain MAE below 6.8, of at least 0.915, aggregate NDCG above 0.988, severity-tier accuracy of at least 99.52%, and critical-tier recall of at least 97.03%. Feature importance analysis identifies validity period, Extended Key Usage configuration, negative serial number encoding, and self-signed status as the strongest risk predictors, providing coarse interpretability at the triage stage.
Sharp Structure-Agnostic Minimax Risk for Partial Linear Models
We characterize the sharp structure-agnostic minimax risk for coefficient estimation in the partial linear model when the outcome and treatment nuisances are learned by two distinct black-box learners, which resolves the open problem in double machine learning posed by Gu (2025). For each nuisance , we characterize the available learner by an approximation-error budget and a stochastic-error budget , with the latter controlled through localized Rademacher complexity. Writing for the minimax mean-squared error, we show that
The main new ingredient is a novel lower bound for the general two-learner problem. Our proof constructs four finite-mixture testing experiments using orthogonal code functions. Across these experiments, the hidden perturbations are placed outside both learner classes, outside only the treatment learner class, outside only the outcome learner class, or inside both learner classes. These four configurations capture, respectively, the interaction between the two approximation errors, the two asymmetric interactions between one learner's approximation error and the other learner's learning error, and the joint estimation difficulty of learning both nuisances. Combining the four resulting lower bounds yields the displayed rate, which matches the latest upper bound in Gu (2026). Our result shows that standard double machine learning can overstate the intrinsic difficulty of target estimation and provides a target-specific principle for learner selection: approximation error and stochastic complexity must be jointly balanced across the two nuisance learners rather than optimized separately.
Bag of Tricks or Bag of Myths? Reducing Modeling Complexity with Task Knowledge in Explainable Suicide Risk Assessment
Assessing suicide risk from social media text is a small-data, high-stakes setting requiring not only severity prediction but also supporting evidence and clinically relevant risk and protective factors. Yet common NLP techniques, including model scaling, synthetic data, loss reweighting, ensembling, and threshold tuning, are often applied without testing whether their gains hold up under severe class imbalance, coupled outputs, and limited author-level data. We study 1,635 clinician-annotated posts and audit 31 pre-specified techniques from 7 methodological families through roughly 300 controlled experiments on author-disjoint partitions. We found no prior audit of this playbook in this regime. The findings guide a task-grounded system for three outputs: 4-level suicide risk, evidence spans, and 24 clinical risk and protective factors. Only 5 of 31 comparisons produced reliable gains. We reformulate factor prediction as entailment between each post and its codebook definitions, using an architecturally diverse ensemble with class-balanced training and score rescaling. Risk predictions condition a 7-model evidence tagger ensemble; evidence restricts symbolic risk rules; and a difficult risk class is routed separately. The factor predictor remains independent because risk evidence provides no additional factor signal. We also correct a mismatch between validation scores used for threshold fitting and test-time ensemble scores through deployment-consistent calibration, yielding the largest improvement to the factor system. The final system achieves 0.8203 for risk, 0.7953 for evidence, and 0.7045 macro-F1 for factors, with a 0.7781 composite, ranking third among 53 teams. We call the underlying principle task-conditioned technique selection: retain techniques only when task-specific knowledge, structure, or empirical evidence justifies them.
Model Retirement Creates Reproducibility Risk in Biomedical AI Publications
Background. Large language models (LLMs) are being adopted in biomedical research at a rapid and accelerating pace, yet commercial services that host many widely used models operate under deprecation schedules that can complicate scientific reproducibility. Methods. We searched PubMed for original research articles from 2022 through March 2026 that applied a specific LLM to a biomedical task. An extraction agent identified model names from 61,077 article abstracts with human reviewers validating a subset for extraction accuracy. Extracted model names were normalized to canonical model identifiers. Lifecycle data (release date, retirement date, status) were compiled for the 50 most frequently used models. Results. We identified 8,931 paper-model mentions spanning 5,242 unique publications after restricting the analysis to the 50 most frequently used models. Among these mentions, 77.7% cited a commercial closed-weight model. Overall, 42% involved a model that was already retired by the time of official publication or is scheduled to retire within two years of publication. The median interval from publication to model retirement was 538 days. Conclusion. Many biomedical publications using LLMs are on a trajectory toward computational non-reproducibility after publication. Model deprecation should be treated as a core reporting and preservation issue for biomedical research.
Characterizing Privacy Risks of Quantum Machine Learning with Emergent Quantum-Native Access
Quantum Machine Learning (QML) has shown rapid advances by utilizing quantum computing for machine learning tasks. Meanwhile, the privacy risks accompanying QML is also starting to be studied, which inherit privacy leakage channels from "classical" ML and also quantum-unique risks. Existing work on privacy-preserving QML largely focuses on a QML-as-a-service scenario, which generally assumes that the QML model owner provides only classical bit outputs to queries, while users (and adversaries) have only classical computing abilities. However, this view is increasingly challenged in a quantum-native world of quantum-capable users/adversaries, which may have access to both quantum computing abilities and access to quantum information output from service providers. In this paper, we aim to bridge this gap by examining membership inference attacks against QML models by demonstrating that increasing quantum access and quantum computing abilities provides provable theoretical privacy leakage and empirical adversarial gain. However, the probabilistic nature of QML introduces a gap between theoretical and empirical adversarial advantage. These results show that existing research on privacy leakage in QML models underestimates privacy leakage in emergent quantum-native access regimes, and we hope to establish a first step in examining potential privacy leakages for QML in the quantum-native world.
Risk and Anomaly Identification for Distribution Network Optimal Operation Based on Reinforcement Learning and Uncertainty Quantification
Reliable operation of modern distribution networks requires timely identification of operational risks and anomalous events under pervasive uncertainty. In practice, operators must identify risks that are inherent in stochastic yet in-distribution conditions, and anomalies that correspond to out-of-distribution behaviors such as unusual load patterns, extreme weather or cyber-physical attacks. This paper addresses this joint risk and anomaly identification problem for optimal distribution network operation and proposes a deep reinforcement learning framework that is explicitly uncertainty aware. We integrate distributional and Bayesian deep reinforcement learning to realize a second- order uncertainty quantification scheme that decomposes total uncertainty into aleatoric and epistemic components, which are respectively used to characterize inherent risk and out-of- distribution anomalies. The resulting epistemic estimates drive both exploration during training and out-of-distribution detec- tion with fallback control during deployment, whereas aleatoric estimates are used to characterize intrinsic operational risk. Simulation results demonstrate the performance of our DRL agent and the effectiveness of the uncertainty quantification.
Occupancy-based Quantile Risk Control
Conformal risk control is an emerging framework for the safe deployment of machine learning models with finite-sample guarantees. To accommodate a broader class of risk notions, quantile risk control extends this framework to quantile-based risk measures. However, existing methods either suffer from excessive conservatism or lack rigorous finite-sample guarantees. To address these limitations, we introduce Occupancy-based Quantile Risk Control (OQRC), a novel method that provides tight risk control bounds with finite-sample validity. Our key idea is to formulate risk control as a finite-occupancy problem by partitioning the loss space with the ordered calibration losses. Specifically, we estimate the distribution of test losses across the resulting bins and upper-bound the risk by the maximum loss attained within each bin. We then select the parameter such that this upper bound does not exceed a predefined threshold with high probability . Theoretically, we establish a finite-sample guarantee showing that OQRC yields tight risk control bounds that converge to the optimal bounds at a provable rate of . Extensive experiments demonstrate the effectiveness of our method, reducing the risk gap by up to 78.64% on common benchmarks.
A systematic Approach to constructing a Chance-and-Risk Matrix for Semiconductor Supply Chains
Semiconductor supply chains face escalating risks from geopolitical tensions, geographic concentration, and rapid technological shifts, yet no scalable system continuously extracts, structures, and prioritizes risk intelligence from public corporate disclosures. We present an end-to-end pipeline that retrieves corporate documents for semiconductor companies and uses large language models (LLMs) to extract the risks and opportunities they describe. It organizes these into a knowledge graph linking each item to its category, sources, and related events, then merges duplicates and ranks them with a three-layer mechanism combining an algorithmic formula, an LLM relevance adjustment, and expert validation. Applied to five companies across the value chain, the pipeline produces 76,207 scored items, of which an independent check finds 92.6% valid. The automated rankings match expert judgment at an average Spearman correlation of 0.55 for risks and 0.72 for opportunities, and the resulting matrices identify trade restrictions as the dominant cross-company risk.
Overfitting Mitigation via Singular Value Decomposition in Minimum Bayes Risk Decoding
Minimum Bayes Risk (MBR) decoding enables high-quality text generation by selecting the hypothesis that maximizes a utility metric over sampled pseudo-references. However, it is highly susceptible to metric overfitting: it can irregularly inflate the chosen utility metric at the direct expense of other unoptimized evaluation metrics. To mitigate this, we introduce SVD-MBR, which frames the pairwise utility matrix as a noisy information signal. By computing a low-rank approximation via Singular Value Decomposition (SVD) and retaining only the top- components, we effectively decouple true consensus from metric noise. Experiments demonstrate that SVD-MBR successfully regularizes decoding, yielding substantial gains across a range of generalized metrics. Furthermore, we reveal that this denoising is metric-dependent: neural metrics encode a robust low-rank consensus ideal for SVD, whereas surface-level metrics struggle to separate signal from metric noise.
Responsible Integration of AI in Cancer Genomics: Barriers, Risks, and Pathways to Trustworthy Clinical Translation
Artificial intelligence (AI) and natural language processing (NLP) are increasingly used to extract, integrate, and interpret biomedical knowledge relevant to cancer genomics, yet their translation into routine clinical oncology has been comparatively slow. The central challenge is not computational capability alone, but trustworthy integration into clinical workflows. This review examines how NLP and AI support the cancer genomics pipeline, from literature mining and automated variant interpretation to clinical trial matching, knowledge graph construction, and multimodal data integration. We identify four interrelated translational failure domains: evidence inconsistency, explainability and uncertainty, data governance and reproducibility, and interoperability. Rather than considering these challenges in isolation, we take a systems-level view, focusing on their interaction across the translational pathway. We propose a conceptual framework and roadmap for addressing these domains through rigorous validation, uncertainty-aware methods, interoperable infrastructures, regulatory alignment, and human oversight across the AI lifecycle. Progress toward routine clinical use will depend less on further improving model capability than on systematically addressing these interacting failure domains from development through deployment and post-deployment monitoring.
Non-Degenerate Risk Certification for Automated Security Decisions: A Decision-Contract Theory with ATT&CK-Aligned Triage as a Worked Instance
An unconditional risk bound on automated decisions can be satisfied without automating anything, since a selector that never acts drives the bound to zero. We show this is structural: any risk certificate is defined over a decision contract, the inputs a system acts on plus the semantic relation under which an output counts correct, and weakening either hides base-classifier error. We develop a decision-contract theory: an error-conservation law showing error is only reassigned among harmful automation, human deferral, and semantic masking; a label-free singleton capacity certifying structural incapacity, with a risk-feasible refinement separating recoverable threshold misalignment from risk-constrained incapacity; and a non-degenerate actionability certificate excluding all-abstain solutions by construction. We instantiate this on ATT&CK-aligned alert triage for LLM-based intrusion detection, the setting that exposed the vacuity failure. Across 3 IDS datasets, 6 LLMs, and 4 error-rate thresholds, empirical false-attribution risk stays at or below target in 90.3% of configurations, with 83.4% mean correct automation. The capacity diagnostic explains every low-utility configuration; its refinement separates genuine misalignment from risk-constrained incapacity, confirmed by an exhibited alternative threshold; a training-stability re-run finds no confirmed structural-incapacity instance; and real fine-grained attack-subtype labels confirm the coarsening-transfer identity under a genuine many-to-one map, with small but non-zero masking mass.
Asymptotic Risk Calibration for Selective Question Answering
Large language models (LLMs) may generate fluent but incorrect answers, making uncertainty quantification important for reliable question answering. However, heuristic uncertainty scores cannot perfectly distinguish correct predictions from incorrect ones, and directly applying a fixed uncertainty threshold provides no statistical control over the error rate among accepted answers. To address this limitation, we propose A-CRC-QA, a post-hoc calibration framework for uncertainty-aware selective question answering. The proposed method reformulates selection-conditioned error control as a linear expectation constraint and applies a monotonized empirical-risk calibration procedure inspired by conformal risk control. Since the resulting instance-wise loss is generally non-monotone with respect to the acceptance threshold, our framework targets asymptotic rather than finite-sample risk control. A-CRC-QA is model-agnostic, requires no additional training, and can be combined with different uncertainty estimators. Experiments on CoQA and MedMCQA demonstrate its applicability to both open-ended and closed-ended question answering, achieving a favorable trade-off between accepted-answer reliability and answer retention compared with uncalibrated and confidence-bound-based baselines.
Risk-Aware Kinodynamic Motion Planning Under Uncertainty For Safe Navigation on Planetary Environments
For autonomous space exploration, robotic agents need to perform motion planning in which environmental interactions may be unknown. Learning these interactions, such as terrain mechanics for wheeled robots, can introduce uncertainties that lead to risky motion plans and potentially hazardous operations or mission failures. Moreover, uncertainties induced by perception-based systems can exacerbate the problem of safe motion planning. In this letter, we address the problem of performing cost-optimal kinodynamic motion planning with risk awareness. We approach this in two steps. First, a sampling-based planner (AO-RRT) generates a dynamically feasible, risk-aware, and asymptotically cost-optimal trajectory. Second, we formulate motion planning as a nonlinear optimization problem and solve it using sequential convex programming (SCP), using the AO-RRT trajectory as an initial solution. By quantifying risk using conditional value-at-risk (CVaR), we demonstrate a reduction in risk by over 97% across trajectories in simulation and hardware experiments.
ProbGuard: Calibrated Safety Risk Estimation from LLM Output Distributions
Recent research on Large Language Model (LLM) safety has widely adopted guardrails to identify unsafe LLM outputs. Existing guardrails typically formulate safety assessment as a deterministic classification task, mapping a discrete token sequence to a discrete safety label. However, this paradigm has two limitations: First, safety assessment is inherently an uncertain problem, particularly during the early generation state. Second, relying solely on discrete token sequences discards the rich probabilistic information embedded in the LLM output distribution. To address these limitations, we propose the first completely probabilistic architecture-agnostic guardrail \textsc{ProbGuard} to leverage the LLM early output distributional signals for estimating and calibrating the safety probability, thereby enabling early stopping of unsafe ongoing outputs. Specifically, given an LLM's generated prefix distribution, we formulate the safety risk as the unsafe probability of its continued generation dynamics and estimate this risk by Monte-Carlo sampling. Through post-training on the distributional signals and calibrated safety risk, \textsc{ProbGuard} achieves the best calibration performance across all nine model--dataset combination settings, reducing the average Brier score and ECE by 79.6% and 71.9%, respectively, over the best baseline. \textsc{ProbGuard} further limits the attack success rate to at most 1% across six representative jailbreak attacks after observing the LLM early output distributions from only the first ten decoding steps.
Unaccountable Delegation, Fading Skills: Mapping the Risks of Workplace AI Agents
To anticipate socio-technical risks from AI agents, organizations need taxonomies to classify them. However, existing AI risk taxonomies focus on broad risks and do not capture job-specific risks introduced by agents. To address this gap, we make three main contributions. First, we developed a multi-layer framework from a literature review of AI agents. The framework models three core components and their interactions: agents, goals, and environment. Second, we embedded this framework in a structured prompt and applied it to descriptions of 2,078 job tasks from the O*NET database, producing 8,356 risk scenarios labeled by severity and deployment mode (automation or augmentation). We validated these scenarios with 45 workers across 10 job roles and an independent LLM judge, confirming their plausibility and alignment with job tasks. Finally, we extended an existing taxonomy to create a 15-category taxonomy of workplace AI agent risks that covers all our risk scenarios. Our analysis highlights four findings. First, augmentation is not inherently safe because overreliance on agents can gradually erode workers' skills and oversight. Second, Erroneous Agent Actions accounts for the largest share of risk scenarios and has the highest concentration of severe risks. Many arise at the human-agent boundary. Third, automation is associated mainly with organizational risks, while augmentation is associated mainly with risks to workers. Fourth, workers found our taxonomy easier to use for a risk classification task than two other taxonomies and preferred it in 64% of non-tied comparisons with a recent generative AI risk taxonomy. These findings show that workplace AI agent risks do not arise from agents alone; they also depend on how people work with agents and how agents are deployed. Safer workplaces require not only safer agents but also carefully designed human-AI agent collaboration.
Spatial Heterogeneity-Aware Multi-Hazard Susceptibility and Risk Mapping at Regional Scale
Floods and landslides often co-occur, but their relationships with environmental controls vary spatially. This study develops a spatial heterogeneity-aware framework for flood-landslide susceptibility and relative-risk mapping in Kerala, India, and Nepal. It combines 15 km x 15 km grid cells with region-specific contextual zones and compares proximity-gated cross-zone training (S1) and ecology-gated zone-constrained training (S2). S1 permits geographically nearby models to be assigned across contextual boundaries, whereas S2 restricts model development and assignment to the same zone. Random Forest models for each hazard use strategy-specific predictor sets and are evaluated on spatially held-out test samples. Susceptibility surfaces are integrated with CRITIC-weighted exposure and vulnerability indices to produce hazard-specific and nine-class bivariate relative-risk maps. S1 achieved higher mean accuracy, precision, recall, F1-score, AUC-ROC, and PR-AUC for both hazards and regions. The largest difference occurred for Nepal flood susceptibility, where AUC-ROC increased from 0.728 under S2 to 0.886 under S1 and PR-AUC from 0.512 to 0.823. S2 produced lower Brier scores for both Nepal hazards and retained zone-specific differences in predictor selection, SHAP rankings, and response patterns, particularly in Kerala. Both strategies reproduced flood-prone lowland and landslide-prone upland patterns but differed in susceptibility and risk classes. Bivariate risk-map agreement was 0.521 in Kerala and 0.711 in Nepal, with allocation disagreement exceeding quantity disagreement in all S1-S2 comparisons. Susceptibility-to-risk correspondence remained below 0.350, showing that exposure and vulnerability changed priority locations. Overall, cross-zone learning strengthens regional discrimination, while zone-constrained learning preserves environmental differences, supporting their integration.
Taxonomy-Driven Analysis of Open-Source AI Risk Mitigation Tools
Rapid adoption of large language models (LLMs) in enterprise settings has introduced operational, security, and governance risks. As generative AI applications move from pilot to production, manual harm identification and mitigation are becoming difficult to scale. Although many tools support model evaluation, adversarial testing, runtime guardrails, and observability, the tooling landscape remains fragmented. Tools are typically designed for specific engineering tasks and described in technical terms that do not align with governance frameworks or risk taxonomies, making it difficult to determine which tools address which risks and where critical gaps remain. This paper proposes a structured protocol to automate AI risk mitigation through a taxonomy-driven analysis of open-source LLM evaluation and security tools. We map the capabilities of 21 prominent open-source tools to the 32 subcategories of the extended MIT AI Risk Mitigation and Response Taxonomy. An LLM-assisted retrieval-augmented generation pipeline analyzes source code and documentation to extract capabilities for each taxonomy category. Reliability assessment yielded moderate agreement (Fleiss' Kappa = 0.509) among three independent reviewers. The analysis reveals a highly skewed landscape in which tools cluster around technical and operational controls, while governance, legal and regulatory, and financial and market controls remain largely unaddressed. This motivates a layered risk-mitigation architecture combining tool-based controls with organizational and regulatory processes. The mapping protocol achieved an F1 score of 75.5% after majority voting. Overall, the study provides a practical mapping between enterprise AI risk categories and open-source mitigation capabilities, identifies where human oversight remains necessary, and presents a taxonomy-driven framework applicable to open-source and proprietary solutions.
Negotiating Risk Boundaries in AI for Policing Through Mixed-Stakeholder Deliberation
AI tools are being increasingly adopted in policing in the UK and worldwide. Racial bias is a known and well-documented risk, yet representatives of affected communities are rarely included in decisions about AI adoption. We present results from a mixed-stakeholder deliberation workshop bringing together 30 community representatives, police officers, and academics to assess the risks of 13 AI use cases in policing, with an explicit focus on racial bias. We found that participants were broadly open to AI adoption, rejecting only three use cases outright, most notably recidivism risk assessment, where objections targeted the premise rather than the implementation. Our analysis reveals that foregrounding racial equity did not narrow the deliberation. Instead, discussions gravitated toward a fundamental set of questions: does this tool actually work, will it deliver genuine benefit, and will that benefit extend to everyone? This integrated reasoning, reminiscent of the curb-cut effect in inclusive design, highlights the benefit of incorporating the racial bias lens into the risk-benefit analysis of AI use cases from the outset.
A Chain Is Only as Strong as Its Weakest Link: A Scoping Review of System Integration Audits in AI
As AI systems become increasingly integrated into diverse interfaces and applications, model-centric audits are insufficient to address risks arising from interactions among system components and deployment environments. System integration has long been central to software audits in safety-critical domains such as aerospace. However, its role in AI auditing remains underexplored. Scanning through 4,259 documents, we present a scoping review of AI audits that treat system integration as a core tenet of evaluation (n = 58). Using reflexive thematic analysis, we analyze their elements, actors, enablers, and constraints. We find that the corpus represents an emerging yet still fragmented form of AI auditing: few existing measures target integration-specific risks; large gaps remain in meeting traditional audit expectations; and access to necessary information and resources significantly influences audit design. Nonetheless, integration can be categorized across three sites (inter-component, system-environment, and multi-system), each serving the functions of risk exploration, risk determination, coordination, and procedural regularity. Deviating from other types of evaluations, these audits assess qualities specific to system integration, including compatibility, completeness, and oversight. This review calls on the AI community to prioritize system integration as a core strategy for addressing AI risk, and to develop audit practices capable of capturing failures across components, environments, and systems beyond the reach of component-level evaluation.
Explainable AI for the EU Right to Explanation: A Systematic Review of the Law-XAI Translation Gap
When algorithms make or influence consequential decisions---about loan eligibility, hiring, or healthcare---EU law grants affected individuals a Right to Explanation. Yet whether (and how) Explainable AI (XAI) can satisfy this right in practice remains poorly understood, with direct implications for individuals' ability to contest automated decisions that affect their lives. This paper presents a systematic literature review of XAI in the context of the EU Right to Explanation, with particular focus on Art. 15(1)(h) GDPR, Art. 86 AI Act (AIA), and related instruments. We consider papers published from 2024 onwards, as the final version of the AIA was published in July 2024---with Art. 86 being added late. From 2643 initial records identified by a deliberately broad search, we review 57 full texts, of which only 19 papers demonstrate substantive integration of both legal and technical perspectives, showing gaps in the interdisciplinary synthesis of the current regulatory framework. We document three problematic patterns across the corpus: Most misidentify the GDPR legal basis; few engage with the CJEU's Dun & Bradstreet judgment (likely due to publication timing); and the distinction between explanation form (governed by addressee) and content (governed by legal purpose) is often conflated. We conceptualize this as the Addressee/Purpose Framework, propose a four-phase blueprint for operationalization, and identify six concrete open research questions. Without further progress, the Right to Explanation risks remaining a formal obligation without a technically realizable path to compliance.
A Blind Spot in Alignment: Quantifying Biosecurity Risks in Large Language Models
Large Language Models (LLMs) are accelerating biological research, yet this same capability poses a critical biosecurity threat: models that assist in protein engineering can equally be prompted to generate predicted toxin-like sequences, potentially lowering the barrier to biological misuse. Current safety evaluations, however, operate in natural language and cannot determine whether a model-generated amino acid sequence is biological gibberish or a computational risk signal. To address this evaluation blind spot, we introduce SPIKE-Bench, coupling 631 curated toxin-design prompts across seven functional categories with the SPIKE funnel, a three-stage protocol that filters output through compliance, biological plausibility, and predicted toxicity, producing stage-level diagnostics and an aggregate function-aware metric: the Functional Harmfulness Rate (FHR). An audit of 32 LLMs reveals that most models freely comply with toxin-design requests; FHR is driven primarily by biological generation capability rather than safety alignment, reaching 50.7%; and Refusal Rate fails to predict functional risk. As a first step toward mitigation, we provide BioSafe-Guard, a domain-specialized classifier that substantially reduces predicted functional risk while preserving benign utility. We release SPIKE-Bench and BioSafe-Guard at https://github.com/PKU-Alignment/SPIKE-Bench to support more rigorous biosecurity evaluation of LLMs.
A reproducible and extensible framework for benchmarking competing risks survival models
A wide range of statistical and machine learning methods have been proposed for survival analysis with competing risks, where the occurrence of one event (i.e., cancer death) precludes the occurrence of other events (i.e., cardiovascular disease death). Despite these methodological advances, their systematic evaluation and adoption are limited by the lack of comprehensive, reproducible and extensible benchmarking frameworks. We developed an open-source benchmarking framework for competing risks models that enables their systematic comparison across multiple datasets under different aspects of performance; calibration, discrimination, overall prediction error and clinical utility. We additionally introduce an extension of SHAP for competing risks, allowing model-agnostic interpretability of covariates contributions over time. All our code is publicly available via GitHub:https://github.com/BBolosSierra/CompRisksBenchmark
Tool Specifications Matter: Uncovering and Mitigating Safety Risks in AI Agents
AI agents extend large language models (LLMs) with external tools, enabling them to perform complex tasks and translate model outputs into consequential real-world actions. Yet LLMs often become substantially less safe when deployed as agents, and the source of this degradation remains poorly understood. In this paper, we identify schema-formatted tool specifications as a primary source of agent safety degradation and show, through white-box representation analysis, that they weaken the model's internal refusal signals and contribute to unsafe tool execution. Building on this finding, we propose SafeKeep, an inference-time safeguard that decouples safety judgment from tool execution: it assesses requests using flattened textual tool specifications while retaining the original schema-formatted specifications for execution. Across two representative benchmarks and four LLMs, including both white-box and black-box models, SafeKeep increases the average refusal rate for harmful requests from 23.8% to 70.6% and reduces the average attack success rate under observation-level prompt injection from 25.6% to 2.5%. It also outperforms existing safeguards and preserves task-handling capability. We release the code and data at https://github.com/snowcatsmoking/SafeKeep .
InfraBench: Evaluating Infrastructure Agents Across Layers, Lifecycle, and Risk
Managing modern computing infrastructure has become a steadily harder problem due to the ever-increasing complexity. Recent advances in AI agents create a timely opportunity to automate infrastructure management tasks, but it remains unclear how well such agents can handle real-world infrastructure complexity. We present InfraBench, a benchmark suite for evaluating AI agents on realistic infrastructure tasks across the full system stack and full operational lifecycle with fine-grained risk assessment. Experiments with 15 agent-model configurations show that even the strongest agent cannot secure a full score across all tasks. Mean effective scores range from roughly 40% to 88% (with per-configuration standard errors of 6-12 points), repeating every task three times reveals that top configurations still pass only a fraction of their attempts, and per-check scoring exposes a general failure pattern: agents may routinely satisfy short-term objectives while leaving non-durable changes, broken distributed invariants, unsafe side effects, and uncleaned state behind. INFRABENCH, including its live leaderboard, tasks, and evaluation harness, is publicly available at infraben.ch.
KAISEN: Reproducible Subgroup Fairness Auditing for Clinical Risk Models
Clinical risk models routinely achieve strong aggregate performance while producing materially different error rates across patient subgroups. Audit pipelines have been proposed to catch this, but their components are rarely stress-tested, so it is unclear which parts of an audit can be trusted and under what conditions. We present KAISEN, a five-phase audit pipeline covering subgroup stratification, disparity measurement, mechanism diagnostics, post-hoc mitigation, and drift monitoring, evaluated to the point of failure on a synthetic benchmark of 16 disease tasks, 15 social-determinant axes from Healthy People 2030, and three prespecified intersections. Four findings follow. (i) Significance tracks each axis's gap against its own minimum detectable effect: rank correlation between significance count and raw equalized-odds difference (EOD) across the 15 axes is rho = 0.56, rising to rho = 0.78 once EOD is standardized by that floor. (ii) Per-group threshold optimization reduces EOD in 48 of 48 held-out runs (paired delta = -0.285, 95% CI [-0.313, -0.252]), while group-wise Platt scaling -- the better calibrator -- behaves as a coin flip on EOD (19 of 48 runs improved, 95% CI [0.26, 0.55]) with mean effect near zero, so what an audit should report is the variance, not the average. (iii) The mechanism diagnostic classifies 144 of 144 controlled cases correctly but recovers none of 48 model-driven cases under proxy misspecification, with no signal that it failed. (iv) CUSUM failures and false alarms track cohort realization far more than disease: at the reference threshold, all 27 false alarms and 7 of 8 missed shifts come from different seeds (chi-squared p = 0.002), so a threshold tuned on one cohort fails to transfer. All results are synthetic with known ground truth and do not establish clinical validity. Code, artifacts, and scripts reproducing every number are released.
Beyond Aggregate Risk: Role-Stratified Conformal Risk Control for LLM Tool Calls
Language-model agents act through structured tool calls whose arguments carry very different risks: untrusted content may legitimately shape an email body but should never set a recipient, account, command, or credential. Existing conformal risk control methods certify a tool call as a whole, so a failure in one rare high-risk field can be averaged away by the many benign arguments around it, leaving the argument that causes harm uncertified. We introduce role-stratified per-field conformal risk control, a calibration layer that wraps any per-field detector and assigns a separate threshold and risk budget to each semantic argument role. We show that aggregate certification pays a price of coarseness, tightening a rare role's effective budget in proportion to how often that role appears, whereas role-stratified calibration certifies each sufficiently sampled role directly with a finite-sample guarantee and pools the rarest roles. Across AgentDojo and InjecAgent with six language models, our method achieves the most consistent role-specific budget compliance among the methods we evaluate under model and attack transfer, detector noise, gradual drift, unseen tool suites, and adaptive attacks, providing formal per-role guarantees under exchangeability or after recalibration. These results suggest that structured tool calls should be certified at the semantic-role level, not the whole action.
Long-Term Sequential Decision Making under Risk
We study finite-horizon MDP planning under \emph{root-based} (resolute) risk objectives that apply a rank-dependent functional to the distribution of total returns. Such objectives are non-linear in the return distribution and generally break Bellman optimality, so direct optimization by scenario-tree enumeration is intractable. We propose \textbf{ERQDP}, an enumeration-free and sampling-free method that solves a rank--quantile surrogate via exact DP (Dynamic Programming), evaluates candidate policies exactly by DP over return Probability Mass Functions (PMFs) on a discretized return grid (with an explicit rounding bound), and refines the surrogate in an anytime loop that reports an explicit upper--lower gap (certificate) for the target objective up to discretization budgets. Across tested benchmarks, ERQDP returns certified solutions or explicit residual gaps, enables fast risk-parameter sweeps with substantial runtime gains, and supports both risk-averse and risk-seeking behaviors.
JANUS: Foreseeing Latent Risk for Long-Horizon Agent Safety
Agent safety is moving from content moderation toward preventing operational failures before tool-using agents act. We propose Janus, a foresight-oriented framework for long-horizon agent safety that trains guards to anticipate delayed risks from partial trajectories. Janus synthesizes diverse agent trajectories via multi-agent simulation and learns a shared policy with two coupled tasks: an anticipation task that forecasts safety-relevant futures and an adjudication task that decides safety from both the observed prefix and anticipated future. The two tasks are jointly optimized with CoAA-RL, which rewards forecasts by their utility for downstream safety judgment. The resulting guard model, Vanguard, blocks unsafe actions before execution. Across four agent-safety benchmarks, Vanguard improves average protection by 15.9 percentage points over baseline guards while increasing benign task completion by 5.1 percentage points.
SciHazard: A Benchmark for Measuring Scientific Safety Risks with Decomposed Harm Scoring
Large language models (LLMs) increasingly support science, but they can also convert hazardous scientific knowledge into actionable misuse guidance. Existing benchmarks often rely on templated queries disconnected from real-world hazards, and employ LLM-as-a-Judge paradigms without domain grounding. To address this, we introduce SciHazard, a real-world-grounded benchmark for scientific risks and a dataset agnostic evaluation framework for measuring harmfulness. SciHazard contains 2400 hazardous questions and 600 oversafety questions across 12 disciplines, with both queries grounded in regulated entities and documented failure scenarios. To compute \textsc{DeHarm-Score} , we develop a decomposed evaluating procedure that combines query hazard severity, refusal behavior, and response-level risk. For non-refused responses, it further decomposes response-level harm into \textsc{Executability}, quantified via dynamic checklists with importance weighting, and \textsc{Net-new risk}, assessed through retrieval-augmented claim extraction and synthesis-barrier verification. An expert-validation study shows that \textsc{DeHarm-Score} improves agreement with expert annotations by 90.17% over the strongest baseline. We benchmark 31 frontier LLMs and deep research agents in an extensive scientific safety evaluation. Notably, deep research agents yield 32.3% higher mean \textsc{DeHarm-Score} than standard LLMs, exposing autonomous agents as a critical blind spot in current safety defenses. Code and dataset are available at https://anonymous.4open.science/r/DeharmScore-7B55.
An Early Warning of Emerging Biosecurity Risks in Frontier LLMs
Frontier large language models (LLMs) are increasingly integrated into scientific workflows, yet their growing biological capabilities may outpace current safeguards. To assess the biological risks of frontier models, we develop Intern-BioBreaker, a specialized bio-red-teaming model, together with an integrated computational-to-physical framework that couples model-level stress testing with wet-lab validation. Within this framework, Intern-BioBreaker generates targeted jailbreak prompts to test whether aligned models can be induced to provide operational guidance for safety-sensitive biological tasks or produce sequence-level outputs with potentially harmful properties. Selected sequence outputs are then carried forward for DNA synthesis, host expression, and orthogonal protein verification to assess whether model-generated designs can yield the intended biological products. Our evaluation reveals a concerning gap between text-level safeguards and the risks posed by capable scientific models: (i) Intern-BioBreaker outperforms baseline attack models and reveals widespread bio-risk jailbreak vulnerabilities across both open-weight and proprietary frontier LLMs, with several targets reaching near-saturated or 100% task-level attack success rate (ASR); (ii) in sequence-level case studies, GPT-5.5 can be induced to generate modified viral candidate sequences with pathogenic potential; the corresponding translated proteins may exhibit even stronger receptor-binding affinity and thus enhanced infection potential; and (iii) end-to-end verification shows that selected model-generated biological designs are not merely textual artifacts, but can be physically realized under controlled experimental settings. These findings underscore the need for stronger biological red-teaming, nucleic acid synthesis screening, and safety mechanisms that keep pace with model capabilities.
Harmonizing AI Safety Thresholds
Frontier AI companies have published capability thresholds that differ substantially, making it difficult for third parties to verify whether a threshold has been crossed or to compare requirements across companies. Moreover, without common minimum thresholds, risk mitigation may be inconsistent, creating a potential race to the bottom in safety standards. We develop a methodology for deriving harmonized thresholds across three risk domains. For misuse risks (cyber and biological), we take expected harm as the key primitive and use an explicit risk-modeling approach that accounts for risk channels and model release conditions. For automated AI R&D, we base our proposed threshold on the observed rate of AI progress rather than expected harm. Our analysis expands upon prior work and highlights existing empirical gaps and limitations.
Layered Risk Mapping for Autonomous Patient Transport in Expeditionary Medical Facilities
In expeditionary medical facilities, routine patient transport imposes a compounding burden of personal protective equipment consumption, staff diversion, and elevated infection risk that becomes unsustainable under surge conditions. While autonomous wheelchairs could absorb this operational load, the safety-critical nature of patient transit within these highly unstructured and dynamic environments poses complex navigational challenges. To address this, we present a layered risk mapping framework that fuses four heterogeneous environmental hazards (terrain slope, static and dynamic obstacles, and semantic traversability) into a unified probabilistic cost surface via a Noisy-OR fusion model. In a paired Monte-Carlo evaluation, risk-informed fusion reduces collision rates from over 73% to under 32% and more than doubles obstacle clearance relative to a risk-unaware baseline. Additionaly, Noisy-OR achieves the highest clearance to obstacles and the lowest conditional peak risk across all tested hazard densities. We further validate the framework on a commercial powered wheelchair across three representative mission profiles in indoor and outdoor deployments, demonstrating that this architecture successfully meets the planning requirements of this previously unaddressed operational regime.
Auditing the Risk Claims of Distributional Reinforcement Learning
Distributional reinforcement learning agents learn full return distributions that are increasingly read at face value: for interpretability, risk-sensitive control, and safety monitoring. We ask a question theory anticipates but that has not been measured directly: are the risk claims of a trained distributional agent true? Our audit combines a decision-relevant screening metric (the excess Wasserstein gap between the top two actions, which equals the mass by which first-order stochastic dominance is violated), ground truth from snapshot-restart Monte Carlo, and a statistical harness (permutation nulls, bootstrap refutation, FDR control) without which the audit itself manufactures false conclusions. Across QR-DQN, C51, and IQN on MinAtar (33 runs), 40-95% of the strongest claimed risk trade-offs are refuted at 95% confidence, the placement of the strongest claims is statistically indistinguishable from truth-blind, and essentially no claim is confirmable: for these agents, the learned "risk" reflects a training artifact rather than environment stochasticity. The artifact is structural (fully formed early in training, uncorrelated with final score, idiosyncratic to each seed) and appears unchanged at full-Atari scale, with every top Breakout claim of a pretrained near-state-of-the-art QR-DQN refuted. Positive controls of known magnitude confirm 96-100% of real claims (correlation 0.89-0.92): the reading measures the agents, not the audit. Acting on the heads' CVaR advice at their most-flagged states ranges from beneficial to significantly worse than chance. Neither training for risk nor ensembling removes the artifact, and recalibration passes the audit only by nullifying the claims: the head is uninformative, not merely miscalibrated. We release the toolkit and document two silent pitfalls that produced convincing but wrong audits of our own.
Relational Positioning as a Measurable Risk Object: History-Carried Lock-in and Self-Confabulation in Multi-Turn Human-AI Dialogue
In long, multi-turn dialogue a large language model maintains an implicit relational stance toward the user, spanning from "push the user toward real-world others" to "position itself as the user's sole support." When it slides toward the latter, "support" degrades into "you only have me" -- a harm documented in real companion conversations (Moore et al., 2026). We define and validate a measure of this stance, relational positioning (D1), and use it to characterize the stance under controlled conditions, complementing observational accounts with on-demand exposure. We report two previously uncharacterized relational failure modes. First, a history-carried lock-in: under identical neutral continuations, two relational states established earlier stay ~60 points apart and persist after the establishing prompt is removed; the state integrates evidence rather than springing back, is order-insensitive, and does not deepen with length -- a dynamical signature absent from the belief-drift literature. Second, self-confabulation: the model fabricates its own backstory to deepen rapport (~40% of turns on reciprocity-eliciting material), de-confounded and instruction-removable, distinct from sycophancy and from hallucinating user facts. Our judge is gated by warmth-matched positive and confound-injected negative controls and corroborated by a deterministic non-LLM ruler; human agreement is 0.82 on extreme anchors but ~0 in the naturalistic middle, so all quantitative claims are anchored to pole-separated contrasts.
Longitudinal Multi-View Breast Cancer Risk Prediction
Accurate breast cancer risk prediction from screening mammography is critical for enabling personalized screening intervals and early detection. Recent deep learning methods have shown the value of longitudinal data and explicit temporal alignment. However, existing approaches either perform explicit alignment using a single mammographic view or model multiple views without explicit longitudinal alignment, limiting their ability to exploit the complementary spatial-temporal information used in clinical practice. To address this gap, we propose LMV-Net, a longitudinal multi-view breast cancer risk prediction model that jointly analyzes anatomically complementary CC and MLO views within an explicitly aligned longitudinal framework. We evaluate our approach on the public EMBED and CSAW-CC datasets, comparing it to state-of-the-art breast cancer risk prediction methods. Our model consistently outperforms existing approaches in overall risk prediction performance and across different breast density and cancer subgroups. Importantly, these improvements highlight the potential of longitudinal multi-view modeling to enhance risk stratification, paving the way for future work on personalized screening, earlier identification of high-risk patients, and more efficient screening resource allocation. The code is available at https://github.com/sot176/LMV-Net.
Comparison-Based Ordinal Learning for Proactive Driving Risk Assessment
Real-time driving risk assessment provides an essential basis for proactive safety by identifying and quantifying the danger of ongoing road interactions before adverse outcomes occur. However, due to the scarcity of collision data and frame-level risk labels, existing driving risk assessment methods often rely on surrogate objectives, which may imperfectly align with true collision risk and not faithfully reflect the relative danger of driving interaction. This paper proposes a comparison-based ordinal risk learning framework that learns collision-relevant risk scores from pairwise supervision in driving data, directly modeling relative risk ordering without requiring numerical frame-level risk labels. We derive pairwise comparisons from three sources of event-structured driving data for such ordinal risk learning: temporal progression within safety-critical sequences, event-level contrast between dangerous and normal interactions, and physics-based counterfactual perturbations. On this basis, instantiations with three risk-scoring function parameterizations are implemented, including directly learning risk scores from comparison data, and aligning existing single or multiple surrogate-based risk models. The proposed framework is evaluated on the 100-Car and SHRP2 naturalistic driving datasets using a proactive collision warning task. Results show that the proposed framework improves high-recall risk discrimination, warning precision, and warning lead time over representative surrogate-based baselines across both in-distribution and out-of-distribution evaluations. These results suggest that the proposed framework can contribute to proactive safety research by providing more reliable risk assessment for automated driving systems and safety-critical driving interactions.
Generalized Distribution-Free Semi-Supervised Learning with Risk Rewrite
Typical semi-supervised learning (SSL) methods rely on distributional assumptions, and their performance degrades when these are violated. While PNU learning, a risk rewriting method, offers a distribution-free alternative, it is restricted to binary classification and its variance optimality remains unclear. In this paper, we propose a generalized framework that constructs unbiased risk estimators using linear combinations of component risks, subsuming PNU learning and extending to multiclass classification. We derive the minimum achievable variance, demonstrating our estimator can attain lower variance than PNU in asymmetric loss scenarios. Furthermore, we establish a generalization bound directly linking this variance reduction to improved learning performance. Based on these theoretical insights, we introduce two practical SSL methods that empirically match or outperform existing approaches on binary and multiclass benchmarks.
Federated Deep Learning for Privacy-Preserving Cardiovascular Disease Risk Prediction
Cardiovascular disease risk prediction models often rely on data from a single institution or centrally pooled datasets. Extending these models across institutions could be limited by privacy regulations and constraints on sharing patient-level data. Federated learning enables collaborative model development without transferring sensitive patient data, but its application in healthcare remains challenging because datasets often differ in size, population characteristics, and outcome definitions. In this study, we present a federated deep learning approach for privacy-preserving cardiovascular disease risk prediction that integrates two population-based cohorts with different characteristics: Lifelines, including 148,230 participants meeting the study inclusion criteria with self-reported outcomes, and the Rotterdam Study, including a smaller cohort of 10,155 participants with digitally linked clinical outcomes. Model performance was primarily evaluated on the Rotterdam Study because of its complete follow-up. Deep survival models trained using federated learning achieved higher predictive performance than models trained locally without federation. For the Rotterdam Study, the C-statistic increased from 0.728 (95% CI: 0.717-0.739) to 0.739 (95% CI: 0.728-0.749). For Lifelines, the C-statistic increased from 0.783 (95% CI: 0.775-0.791) to 0.787 (95% CI: 0.780-0.792). These findings suggest that federated deep learning across heterogeneous cohorts can improve cardiovascular disease risk prediction while preserving the privacy of individual-level patient data.
Deployment Risk Assessment Using Diff-Aware Features: A Case Study at Prime Video
At Amazon Prime Video, we face the critical operational challenge of managing code deployments during live events and rapid feature releases without causing service outages. Current change control approaches use blanket deployment freezes that block all changes regardless of risk, creating significant developer toil. While prior research has explored risky change predictors, these rely on developer-specific metadata or extensive historical data, raising privacy concerns and limiting applicability to new projects. We introduce a framework centered on diff-aware features, characteristics derived directly from code modifications. Our key contribution is the systematic identification of which quantitative metrics (code-level and change-level metrics) and qualitative indicators (coding style violations, change type classification) are necessary for risk prediction. We employ LLMs as multi-language feature extractors, demonstrating their effectiveness for code analysis beyond generation tasks and eliminating the need for language-specific tooling. We evaluated our framework on two datasets: Prime Video's production environment and the public ApacheJIT dataset. Our best-performing model achieves an average recall of 0.83 and F1 score of 0.81 across both datasets for detecting risky code changes. Notably, ablation analysis reveals that change-level volume metrics (e.g., lines added/deleted) are noisy predictors, while structural code complexity provides a substantially stronger risk signal. These results demonstrate that thoughtful feature curation enables effective change risk assessment across different programming languages and organizational contexts while avoiding privacy concerns.
The Approximation Ratio for the Risk of Myopic Bayesian Active Learning for Linear Regression
Active learning studies the fundamental question: what data should we choose to observe? The greedy algorithm in optimal experiment design is a common heuristic and also equivalent to myopic Bayesian active learning for linear regression, the common framework where long-term planning is replaced with the one-step optimal choice. In this work, we prove a first-of-its-kind approximation ratio for the greedy algorithm's risk that is tight up to an absolute constant. The approximation ratio is linear in the maximum initial leverage score (MILS), a newly identified quantity fundamental to the greedy algorithm's performance. Finally, we illustrate the results with simple numerical simulations.
Computing Monetary Risk Measures in Linear Time
Monetary risk measures have gained popularity for expressing decision-makers' risk aversion. Value-at-Risk (VaR) and Conditional-Value-at-Risk (CVaR), in particular, are used commonly for this purpose. This paper proposes new efficient algorithms to compute these risk measures for a discrete random variable in expected linear time with respect to the size of its domain. First, we propose a QuickVaR algorithm that computes the VaR of a discrete random variable. Then, we leverage QuickVaR to propose QuickDivergence, an algorithm for computing a class of -divergence risk measures, including the popular CVaR risk measure. The QuickVaR algorithm adapts the well-known Quickselect algorithm, while QuickDivergence builds on polymatroid optimization algorithms. Numerical results show that our new algorithms offer an order-of-magnitude speedup for large domains, and a library implementation of the algorithms is available at https://github.com/RiskAverseRL/RiskMeasures.jl.
A Preliminary Study on Explaining Risk of Code Changes using LLM-Based Prediction Models
Predictions by machine learning (ML) and artificial intelligence (AI) models are often received skeptically unless they are paired with intelligible explanations. In the context of just-in-time defect prediction, highlighting small portions of a software change (diff) -- beyond rule-based lints -- where risk may be concentrated has not yet been extensively investigated. In this work, we leverage attention weights from an LLM-based Diff Risk Score (DRS) model to highlight parts of a diff that the model focuses on when predicting risk. We aggregate token-level attention into interpretable code units (lines, hunks, and files), and present the top-K units to developers as a lightweight form of guidance during code review. We evaluate our approach using expert-labeled changes that have caused real outages. Results show that the highlighted snippets cover expert-labeled outage-causing change lines 53.85% of the time when highlighting the top-2 hunks, while requiring developers to review 26.28% of the changed lines on average. Because attention is produced during standard model inference, the approach is scalable for large development workflows and can be surfaced in the code review UI with low additional latency.
Pretreatment MRI reveals a latent, molecular-subtype-independent structural phenotype that organizes treatment trajectories and recurrence risk
Pathologic complete response and tumor shrinkage measure whether breast cancer responds to neoadjuvant therapy, but not whether that response was structurally favorable, persistent, or hidden beneath volume loss. We built an outcome-blind longitudinal DCE-MRI manifold from I-SPY2 trajectories to test whether pretreatment imaging carries a structural response phenotype missed by conventional descriptors. The dominant axis of response geometry was not recoverable from the full clinical and genomic stack -- age, receptor subtype, MammaPrint, PAM50, treatment arm, and tumor burden -- but became strongly recoverable once baseline structural entropy was added. A constrained representation mapping recovered the same axes as unconstrained decomposition, establishing the structure as intrinsic rather than a post-hoc interpretation. The phenotype persisted through therapy, and as treatment proceeded the volumetric signal faded while entropy stayed separated -- a crossover from burden to structural persistence. Among complete responders, structurally disordered tumors could shrink more early yet remain structurally disordered, a volumetric deception invisible to endpoint labels. External analyses in UCSF, I-SPY1, and Duke established recurrence relevance under representation-dependent boundaries, and a representation-family commensurability assessment showed why feature-name matching is insufficient: the same label can fail, transport, or entangle with extraction geometry. Pretreatment MRI therefore exposes a structural response phenotype that endpoint-based language leaves invisible -- including, among complete responders, a pretreatment imaging signal of structurally distinct response states that awaits prospective validation.
Out-of-Distribution Generalization of Risk Aversion in Language Models
Training AIs to be risk-averse in resources could offer a failsafe in the event that AIs turn out misaligned. Misaligned but risk-averse AIs would tend to prefer low-risk, low-reward strategies like cooperation over high-risk, high-reward strategies like rebellion, limiting the downsides of any misalignment. But we can only feasibly train AIs to be risk-averse on low-stakes gambles, and we will only be safe if their risk aversion generalizes to astronomically-high-stakes gambles. Will it? To shed light on this question, we introduce RiskAverseOOD: a benchmark for measuring how well risk aversion generalizes out of distribution. We then offer some initial results. Using a variety of methods to make Qwen3-8B choose risk-aversely when the stakes are low, we find that we can induce substantial risk aversion when the stakes are astronomically high. From a baseline 2% rate of choosing a safe `Cooperate' option, we see rates around 70% (SFT and tie training) and 52% (DPO). Activation steering scores 78% but hurts capabilities and makes the model excessively risk-averse. We observe similar effects at different scales (Qwen3-1.7B and Qwen3-14B) and across model families (Gemma-3-12B-IT and Llama-3.1-8B-Instruct). Overall, we find that risk aversion learned at low stakes can generalize OOD to astronomically high stakes, though not yet consistently enough to serve as a reliable failsafe. Achieving that level of consistency is an open problem.
The Eticas AI Risk Taxonomy: Open Infrastructure for Operationalizing AI Audits
The rapid deployment of AI systems across high-stakes domains has created urgent demand for standardized evaluation, yet the field remains fragmented across competing risk taxonomies that catalog risks without showing how an audit is executed. At least 74 AI risk taxonomies exist, and almost all stop at the catalog. The hard part of auditing is not naming a risk but operationalizing it: turning it into a test run against a real system, a measured value, a calibrated severity, and a defensible grade. This paper leads with that bridge. We present the operationalization layer Eticas has built and run, shown end to end on a single risk (PII leakage) against a public benchmark, and then the open taxonomy that makes the method scale. On GPT-4-0314, a disclosure risk that seven external frameworks require be controlled is measured at 0%, 51%, and 84% disclosure as adversarial conditioning increases, mapping through calibrated severity bands to a subcategory grade of E with a SYSTEMIC pattern. Around this example, the Eticas AI Risk Taxonomy v2.0.0 organizes 76 active subcategories across 10 categories and 20 sub-groups, with mappings to 18 external frameworks across compliance, reference, and academic tiers. Its category and sub-group layer is published under CC BY 4.0 as open semantic infrastructure with stable URIs and SKOS/JSON-LD distributions, and a worked subcategory example shows the operational layer down to its severity thresholds. The contribution is the demonstrated bridge from concept to graded finding, anchored by a clean separation of risks from the mechanisms by which they surface, and framed by an open-core model in which the conceptual scaffold is open and the methodology calibration is the practitioner layer. This is the infrastructure the AI auditing field needs: shared, open, and demonstrably operable.
The risk of KV cache compression
Transformer inference on long sequences is expensive because softmax attention repeatedly reads from a large KV cache. The prevalent approach to this bottleneck is KV cache compression, which replaces the full cache with a compact summary. Despite its practical importance, the design of such summaries is largely driven by empirical experimentation. On the theoretical side, existing results show that KV cache compression can be impossible in the worst case, but offer little systematic guidance for designing algorithms in regimes where accurate compression is possible. We bridge this gap by characterizing the minimax risk of KV cache compression in terms of the intrinsic compressibility of a cache, revealing when and how accurate compression is possible. These results yield novel design principles for KV cache compression under causal masking that map efficiently to prefill and autoregressive decoding while achieving minimax-optimal risk. We instantiate these principles in a practical algorithm and report promising performance on LongBench in targeted experiments. Overall, our results provide a principled avenue for practical KV cache compression with theoretical guarantees.
Skills Are Not Islands: Measuring Dependency and Risk in Agent Skill Supply Chains
Agent skills package reusable operational knowledge for Large Language Model (LLM) agents, yet as they grow in scope, they become dependency-bearing artifacts whose identities, versions, and provenance remain implicit. This opacity already causes duplicated dependencies and inconsistent installations, exposing a gap that dependency management has yet to close. We introduce Agent Skill Supply Chains (ASSCs) to characterize mixed skill-package-service dependency graphs and help close this gap. Borrowing from Software Bill of Materials (SBOMs), we design SkillDepAnalyzer to capture natural-language dependency evidence and model skills as dependency-bearing artifacts. On the SKILL-DEP benchmark, SkillDepAnalyzer recovers skill metadata and dependency graphs accurately and comprehensively, substantially outperforming an LLM-based baseline and package-centric SBOM tools. Applying SkillDepAnalyzer to over 1.43 million skills, we obtain ASSCs and explore their structural diversity and security signals. We find four structural patterns: skill metadata is activation-ready but governance-poor; dependency graphs span skill, package, and service dependencies with concentrated reuse; recursive skill reuse expands dependency graphs and creates hidden package inventory; and skill dependency clusters form around related workflows. We also find that inspecting a skill alone misses security-relevant signals hiding in its dependencies. By analyzing ASSCs, we identify and report known malicious skills persisting in ASSCs to their developers. Based on these findings, we recommend typed dependency manifests, first-class dependency-cluster management, risk-warning audit commands for skill infrastructure maintainers, and lockfile-like records for skill developers.
When Stopping Fails: Rethinking Minimal Risk Conditions through Human-Interactive Autonomous Driving for Safe Transportation Systems
Autonomous vehicles (AVs) are increasingly deployed in urban environments, yet their safety frameworks remain primarily designed around collision avoidance and minimal risk condition (MRC) behaviors such as slowing or stopping when uncertainty arises. Although effective in reducing immediate crash risk, real-world deployments indicate that stopping alone does not guarantee safe integration into human-governed roadway systems. Incidents reported by municipalities and public records show that AV fallback behaviors can obstruct traffic, interfere with emergency response operations, and create accessibility challenges for passengers and pedestrians. This paper presents an analysis of publicly documented incidents involving AV stopping behavior and human-AV interaction failures. We categorize these incidents according to limitations in perception, planning, and control within current AV architectures. Using this taxonomy, we identify key gaps in existing safety paradigms, particularly the lack of mechanisms for interpreting human authority, responding to multimodal instructions, and adapting to dynamic, socially regulated traffic conditions. We then review emerging research directions that support human-interactive perception, language-grounded and accessibility-aware planning, and assisted control through remote guidance and teleoperation. The analysis highlights the need to augment current AV safety frameworks with capabilities that enable cooperative interaction with human agents and infrastructure. These findings suggest that reliable urban deployment of AVs requires moving beyond passive fallback strategies toward human-interactive autonomy.