Biomechanics

Autonomous precision milling of biological structures is challenged by incomplete knowledge of target geometry, local material thickness, and critical internal boundaries. Subject-specific preoperative models can address geometric and thickness variations, but static models cannot determine boundary status encountered during execution, while repeated target-specific imaging limits scalability. This article presents an uncertainty-aware autonomous milling framework that assigns complementary roles to generic anatomical priors and active boundary perception. A generic anatomical prior provides conservative global guidance and is transformed through semantic-guided registration and hybrid vision-force calibration into robot-executable guidance for individual targets. As milling approaches uncertain boundaries, the robot actively probes the remaining structure and uses relative stiffness changes to estimate boundary status and structural detachability. A state-adaptive controller governs transitions between active perception and spatially selective incremental refinement, repeating this cycle until the termination criterion is satisfied. Hierarchical experiments on biological surrogates and in vivo mouse cranial window creation demonstrate accurate anatomical prior transfer, reliable boundary adaptation, and autonomous precision milling of biological structures.

Monocular pose estimation enables low-cost gait analysis but is sensitive to missing keypoints caused by occlusion, detection errors, or efficiency-driven model reduction. While prior work on recovering missing joints focuses on complex learned models, the effectiveness of simple temporal methods remains underexplored. We evaluate knee-angle estimation under a missing-ankle-keypoint condition and test a first-order temporal interpolation scheme as a recovery mechanism. Across 527 frames of monocular walking video (428 with valid baseline detections), removing the ankle keypoint increased mean angular error to 23.4° +/- 46.7° and collapsed signal variance to near zero. Temporal interpolation reduced error to 1.1° +/- 6.7° and restored variance and smoothness to within a few percent of baseline. These results indicate that gait signals possess sufficient temporal redundancy for a simple, computationally trivial interpolation scheme to recover a critical missing joint, without resorting to learned reconstruction models. The findings support low-complexity, real-time-compatible designs for gait analysis in resource-constrained or occlusion-prone monocular settings.

Understanding animal motion is fundamental to modeling animal behavior and biomechanics, yet progress in this area lags far behind human motion research due to the scarcity of high-quality motion data. While human motion can be captured in controlled environments, it is impractical for most animal species, resulting in small, domain-limited datasets that restrict downstream applications such as animation. To address this challenge, we introduce Kirin, a framework that reconstructs motion from video, learns motion priors at scale, and generates realistic motion that can be directly applied to animated assets. Using large collections of in-the-wild animal videos, we reconstruct 3D motion sequences and pair them with captions to create AiM3D, the first large-scale dataset offering aligned video-text-motion tuples for quadruped animals. Building on this dataset, we develop a visual-guided motion generation model that conditions on both text and image to guide the generation of realistic motion across diverse animal species. Finally, by leveraging an off-the-shelf image-to-3D model, we automatically rig and animate 3D meshes using generated motion, producing ready-to-render animated animals. Together, our dataset and framework establish a new foundation for large-scale, text and image conditioned animal motion generation and animation. Project page: https://kirin-ani.github.io/.

State-of-the-art monocular body recovery methods predict mesh vertices and angles on the corresponding kinematic tree, but their outputs lack biomechanically defined joint angles that downstream applications like clinical and biomechanical analyses require. We extend an existing foundation model, SAM-3D-Body, with an additional biomechanical prediction head that, from a single RGB image, regresses the joint angles and scales of a biomechanical model. Training this model presents a challenge, as there are limited datasets of paired images and biomechanical fits. To overcome this, we supervise biomechanical outputs with in-loop optimized targets from a Levenberg-Marquardt solver performing inverse kinematics fits against markers from the mesh predictions. This allows distilling the biomechanical head from the mesh head, even from unlabeled images. To make this work with GPU-optimized biomechanical models in MuJoCo, the entire model was implemented in JAX using Equinox. We trained this distilled output head on the publicly released SAM-3D-Body dataset. We then validated this model on biomechanical fits to two publicly available marker-based datasets, MoVi and BioCV, as well as movements from a clinical cohort captured with multiview markerless motion capture. The resulting model outperforms existing models for direct regression of biomechanics from images while only slightly underperforming the state-of-the-art monocular biomechanics method that performs more costly inference-time optimization of entire trajectories.

Estimating human joint torques from visual observations is a key step toward bringing biomechanical analysis from controlled laboratories to real-world movement scenarios. Existing torque estimation methods typically depend on surface electromyography, motion-capture markers, force plates, or simulated imitation data, which limits their applicability to ordinary RGB images. In this work, we introduce VID, a vision-based inverse dynamics dataset and benchmark for predicting human joint torques directly from real monocular images. VID contains 63,369 synchronized frames with real human images, kinematic annotations, anthropometric attributes, and OpenSim-derived dynamic labels, providing paired visual and biomechanical supervision for real-image inverse dynamics. We further define a standardized evaluation protocol covering overall torque estimation, joint-specific analysis, and action-specific prediction. To establish a strong reference model, we propose VID-Network, which combines pose-pretrained spatial probabilistic features, marker regression, and temporal torque inference to recover joint torques from image sequences. Experiments on VID show that VID-Network achieves an overall mPJE of 1.7612 N$\cdot$m/kg, improving over the best compared baseline by 39.81%, and obtains the lowest error across all evaluated joint types and most action categories. VID establishes a first practical benchmark for vision-driven human inverse dynamics and provides a foundation for studying biomechanical inference in less constrained environments.

Computed tomography (CT) remains the reference for 3D osseous morphometry in femoroacetabular impingement (FAI) but requires ionizing radiation and manual measurement. Zero echo time (ZTE) MRI visualizes cortical bone and yields FAI angles that agree with CT, but automated angle extraction remains limited. We developed and validated automated FAI angle computation from ZTE MRI and assessed agreement with expert manual measurements in a cross-sectional study (level of evidence, 3). Pelvic ZTE MRI was acquired in 73 participants (mean age 36.8 +/- 18.5 years; 51 women, 22 men), yielding 135 hips. nnU-Net was trained on 100 manually curated hips to segment the femur, pelvis, and three osseous landmarks. Custom geometric algorithms computed alpha, femoral neck-shaft, Tonnis, coronal and sagittal center-edge, and acetabular version angles from inferred segmentations. Measurements on 35 test hips were compared with the mean of two radiologists' manual measures using intraclass correlation (ICC) and Bland-Altman analysis. Dice exceeded 0.96 for bone and ranged from 0.65 to 0.83 for landmarks. Median landmark error was 0.38 mm (femoral head), 0.82 mm (lateral acetabulum), and <2.5 mm (medial acetabulum, greater trochanter). Interrater ICC was excellent for acetabular version, coronal center-edge, and Tonnis (>=0.82) but poor for alpha and femoral neck-shaft. Model versus rater-mean agreement was excellent for acetabular version, coronal center-edge, and Tonnis (0.92-0.96), good for mid-acetabular sagittal center-edge (0.74), and fair for alpha (0.45) and femoral neck-shaft (0.55). Model Bland-Altman limits of agreement were narrower than interrater limits for most angles. Fully automated morphometric assessment from ZTE MRI is feasible and performs comparably to expert readers for most coverage and version angles.

The understanding of natural human adaptation during exoskeleton-assisted locomotion - particularly individual differences in adaptation behaviors and temporal progression - remains limited. In this work, we investigate temporal evolution of biomechanical variables to uncover participant-specific adaptation strategies across different exoskeleton-assisted locomotion scenarios. Nine healthy participants performed treadmill walking under three conditions: without an exoskeleton, with exoskeleton active ankle assistance, and with exoskeleton zero-torque. Lower limb kinematics, inter-joint coordination, and metabolic cost of transport (MCoT) were analyzed at both the group and individual levels. Results indicate that adaptation is gradual and highly individualized, with substantial variability in convergence timing and movement patterns across participants. Kinematic adaptation occurred asynchronously across lower limb, with larger fluctuations during the swing phase. Metabolic responses were heterogeneous and often non-convergent, highlighting the limitations of steady-state assumptions commonly adopted in the literature. These findings emphasize the importance of individual-level, temporal evolution analyses for understanding adaptation dynamics in exoskeleton use.

Radar-based human pose estimation has focused on improving learning algorithms while representing the body as unconstrained keypoint coordinates. We address the underexplored dimension of anatomical fidelity by integrating a full-body skeletal model into a differentiable, end-to-end trainable radar-based pose estimation framework, in which the pose network is supervised through forward kinematics while subject-specific geometry is fitted beforehand. Subject-specific body segment proportions are predicted from radar point cloud features to scale a biomechanical skeleton. A motion prediction network maps temporal radar sequences to generalized coordinates, and differentiable forward kinematics converts predicted joint angles into 3D positions. A contact classification loss encourages physically plausible foot-ground interaction. Under leave-one-subject-out cross-validation on 11 healthy participants performing rehabilitation exercises, the framework achieves 6.456 +/- 1.759 cm mean per-joint position error (MPJPE), 8.083 +/- 0.884 degrees mean per-joint angle error (MPJAE), 0.935 +/- 0.009 contact classification F1, and 3.4 +/- 1.3 % scaling error. This proof-of-concept study demonstrates the feasibility of recovering interpretable biomechanical descriptors from a single low-cost radar sensor in a controlled laboratory setting, a prerequisite for future clinical motion analysis.

Learning-based controllers can deliver exoskeleton assistance after training entirely in physics-based simulation, yet few controllers that address human-device co-adaptation have been validated on real users by whole-body metabolic measurement, the standard benchmark for assistive walking. Co-adaptation is challenging: as the device alters joint dynamics, the wearer reorganizes neuromuscular coordination, producing a non-stationary learning problem. Staged Multi-Agent Training (SMAT), a four-stage curriculum that progressively trains a musculoskeletal human actor and a bilateral hip exoskeleton actor, was introduced and shown to reduce simulated hip-muscle activation and provide positive assistance on hardware. This article provides the first physiological validation of SMAT. The policy was deployed on a hip exoskeleton and tested with eight healthy adults, with metabolic cost measured by indirect calorimetry across no-exoskeleton, passive, and active conditions. Active assistance lowered net metabolic rate by 19.7% relative to the passive device (p < 0.001). Biomechanical analysis confirmed predominantly positive hip mechanical power across all subjects (positive-power ratio 0.98), and the policy generalized across walking speeds and terrains. Together, these results show that a single simulation-trained SMAT policy, deployed without subject-specific retraining, delivers a significant metabolic benefit on real users while remaining robust beyond the conditions it was trained on.

Translating unstructured clinical prescriptions into patient-specific foot orthoses (FOs) is hindered by a semantic-physical misalignment: high-level clinical intent is not mapped deterministically onto the 3D geometric parameters of the orthosis, and existing design workflows remain dependent on manual expertise with no instantaneous biomechanical validation. We present TANS-FO, a research prototype-a modular pipeline with closed-loop feedback for computational design automation of customized FOs, not a clinically validated therapeutic device. A Text-Aligned Neural Surrogate (TANS) uses cross-attention to project clinical-text embeddings onto a continuous lattice-density field, while a Graph Neural Network (GNN) surrogate predicts plantar stress in real time as a substitute for Finite Element Analysis (FEA). The framework is anchored on the open-access PicoFoot-5K anthropometric database (5,230 subjects; 30+ anatomical parameters). Under standardized quasi-static loading, the GNN surrogate agrees with an Abaqus reference solver (R^2 = 0.94), and the full pipeline synthesizes manufacturing-ready lattice insoles within minutes. On the Male 18-40 cohort, the proposed system attains a surrogate-predicted peak-pressure reduction of 34.7% over parametric CAD, with a fit error of 0.42 mm. Separately, an exploratory feasibility observation (n = 12; 2-week follow-up; no control group) using VAS pain reporting indicates short-term comfort improvement (VAS 6.4 -> 2.1), but this data is explicitly classified as preliminary observational evidence only-not evidence of clinical efficacy.

Frailty assessments are crucial to evaluate the risk of adverse events and the health and social care needs of older adults, yet their administration remains resource-intensive and typically relies on coarse clinical outcomes, such as task completion times, which may overlook biomechanical indicators of functional decline. To address this, we present a robotic framework that guides older adults through standardised frailty and fall-risk tests while capturing clinical scores and additional frailty-related metrics, offering a deeper insight into a user's condition. The system uses a Behaviour Tree architecture that coordinates perception, decision-making, interaction, and measurement modules. Using vision-based skeleton tracking, the robot evaluates established clinical tests, including the Short Physical Performance Battery (SPPB) and the Timed Up and Go (TUG). The framework was co-designed with healthcare professionals and evaluated in situ during six months in a rehabilitation centre's research lab with N=81 older adults. Robot-derived measurements were compared against therapist assessments and clinical reference instruments, including a gait analysis walkway and an inertial measurement unit (IMU). Results showed excellent agreement for most test completion times and gait-related parameters ($ICC > 0.9$). And, substantial agreement for the overall SPPB score comparing the robot and the therapist ($k = 0.67$) and moderate agreement comparing the robot and the IMU ($k=0.55$). The findings highlight that social robots can provide reliable and objective frailty assessments in healthcare settings while enabling the collection of relevant mobility indicators beyond conventional outcomes.

Recent progress in 3D human pose estimation has made markerless recovery of skeletal motion increasingly accurate and scalable. However, most pose estimators remain optimized for geometric keypoint accuracy, while many real-world applications in rehabilitation, sports science, ergonomics, and clinical movement analysis require biomechanical quantities that describe how the body moves, loads, and activates. In this work, we propose BioModule, a lightweight plug-in temporal transformer that attaches downstream of any 3D pose estimator and predicts biomechanical attributes from standard 17-joint 3D skeletons. BioModule is estimator-agnostic and requires no modification of the upstream pose model, enabling existing pose estimators to be extended toward physically interpretable motion analysis. To train and evaluate BioModule, we construct a large-scale aligned dataset pairing Human3.6M video and 3D keypoints with the biomechanical label space of Human3.6Mplus. We establish and verify anatomical correspondence between coordinate systems of the two datasets, enabling frame-accurate cross-modal supervision. Using this aligned supervision, BioModule predicts biomechanical quantities. We further benchmark BioModule across seven state-of-the-art 3D pose estimators, providing the first systematic analysis of how upstream pose estimation quality propagates to downstream biomechanical prediction fidelity. The results position BioModule as a compact, modular bridge between vision-based pose estimation and biomechanically meaningful human motion analysis.

Markerless motion capture (MMC) techniques have been widely beneficial in biomechanical analysis of human movement; however, application to complex motions of the hand lags other musculoskeletal systems. The primary goal of this study was to evaluate the performance of a biomechanical reconstruction method that implements a gradient-based optimization approach with a biomechanical model in the loop for tracking dexterous, unconstrained hand movements using MMC. Using a custom, 8-camera setup, we acquired 121 video recordings from 6 participants performing 11 different tasks that spanned 6 hand postures, 5 object manipulation tasks, and involved motion of the proximal upper limb joints. Performance of the proposed MMC pipeline was directly compared to a more commonly adopted two-stage reconstruction method that first triangulates 2D keypoints from computer vision pose estimation algorithms to 3D and then enforces biomechanical constraints by solving a constrained inverse kinematics problem. Relative performance was assessed qualitatively by visual inspection and quantitatively using a computer vision metric. Our method generated solutions for all 121 video recordings; the two-stage method did not converge for 15% of the recordings. Across the remaining videos, our method produced more biomechanically plausible hand kinematics than the two-stage method and was more robust to occlusion effects during tasks that involved objects. The relative robustness of the end-to-end method suggests that it is more effective in utilizing the available 2D digital keypoint information. Automatic and biomechanically meaningful tracking of hand kinematics during dexterous movements has the potential to support clinical evaluation, rehabilitation monitoring, and studies of human motor control.

Dexterous robotic hands face a longstanding trade-off among dexterity, compactness, and affordability. Particularly, high-degree-of-freedom designs typically demand complex actuation and transmission, hindering integration into human-scale forms. To address these challenges, this work presents a compact, low-cost linkage-driven anthropomorphic hand that achieves high dexterity, structural integration, and human-hand-like functionality. The hand integrates 20 joints driven by 16 independent actuators, with all actuation, sensing, and transmission components compactly embedded within a human-hand-sized structure. The resulting prototype weighs only 320g at a total cost below USD 400. To meet these objectives, a hybrid mechanical architecture combining planar and spatial linkage mechanisms is proposed, enabling decoupled multidirectional motion, biomimetic joint synergies, and high passive load-bearing capability. The thumb further incorporates biomimetic features supporting human-like reconfiguration and opposition movements. Through the coordinated integration of these mechanisms and structural layout, the prototype achieves a highly integrated design with anthropomorphic dexterity. Experimental evaluations demonstrate that the hand achieves the maximum Kapandji score, reproduces all 33 Feix grasp types, and performs stable grasping and dexterous manipulation across a wide variety of daily objects and tools. These results validate the proposed hand as an affordable, compact, and mechanically efficient platform for dexterous manipulation, teleoperation, and robot learning in human-centered environments.

Accurate intraoperative liver registration is challenging due to substantial soft-tissue deformation yet sparse intraoperative measurements. Biomechanical models regularize this ill-posedness with prior knowledge but exhibit persistent prediction bias due to simplifying assumptions, while data-driven learning solutions struggle with data efficiency, generalization, and physical plausibility. We propose a hybrid registration framework that adapts a biomechanical prior using sparse intraoperative correspondences. Rather than learning a full deformation field, we learn a residual deformation function that corrects linear biomechanical predictions, modeled as a graph neural diffusion function with geometry-aware attention over the 3D liver mesh. To enable long-range information transfer of sparse observations, we take a novel perspective of sparse intraoperative measurements as \textit{context} samples where input-output pairs of the residual deformation function are fully observed, casting the problem into learning-to-learn this residual function from intraoperative context samples with feedforward meta-learners. Experiments on a deformable liver phantom dataset demonstrate improved registration accuracy and generalization compared to rigid, biomechanical, and data-driven baselines, particularly for out-of-distribution geometries and deformations.

Human-robot collaboration (HRC) in prefabricated construction requires planning approaches that consider not only productivity but also time-dependent worker states during repeated work and rest. Existing planning models often rely on simplified assumptions about fatigue, workload, or recovery, with limited domain-specific empirical evidence on how perceived strain evolves. This study develops an empirically grounded, planning-oriented approach to characterize perceived strain accumulation and recovery in prefabricated construction HRC. A controlled repeated work-rest experiment assessed perceived cognitive and physical strain using the Rating Scale for Mental Effort and Borg's Rating of Perceived Exertion. Linear and exponential functional forms were evaluated, followed by mixed-effects modeling to examine collaborative conditions, session effects, and inter-individual variability. Results indicate that cognitive strain accumulation is best represented by a linear mixed-effects model, whereas rest-phase recovery follows nonlinear decay. The resulting planning-oriented models may inform future human-state-aware task allocation and scheduling research.

Designing anthropomorphic robotic hands that balance functional dexterity with mechanical simplicity remains a significant challenge. Inspired by human hand synergies, this paper presents the SyLink Hand, an anthropomorphic dexterous hand that integrates biomechanical synergy principles with linkage-driven transmission mechanisms to achieve a high degree of anthropomorphism in appearance, kinematics, and functionality within a compact and cost-effective architecture. Biomechanical analysis of natural hand motions using motion capture gloves reveals strong kinematic correlations among hand joints, providing the basis for a simplified yet functional degree-of-freedom (DOF) configuration. Guided by these synergistic characteristics, optimized linkage mechanisms are employed to coordinate multiple joint motions and reproduce natural finger trajectories. A novel spherical four-bar linkage is further proposed to achieve decoupled flexion/extension (Flex/Ext) and abduction/adduction (Abd/Add) at the metacarpophalangeal joint within a compact form factor. The resulting prototype integrates 19 joints driven by 11 actuators, with a total mass of 520g and a manufacturing cost of approximately USD 400. Experimental evaluations demonstrate its human-like kinematic performance, high load-bearing capability, and versatile grasping and manipulation skills. These results validate that the synergy-inspired, linkage-based design effectively balances anthropomorphism, mechanical simplicity, and functional versatility, highlighting its potential for practical deployment in dexterity-demanding robotic applications.

With the growing demand for realistic virtual humans, parametric body models have become a cornerstone of modern medicine, sports, and entertainment applications. However, most of these models are inherently limited: they only capture the 3D surface of the skin, offering no insight into the complex bio-mechanical structures that generate motion. As more applications expand towards biomechanics, the need for virtual human models that go beyond the skin has become increasingly evident. Traditional soft-tissue simulations, such as FEM, are accurate but non-scalable and too computationally expensive for most common applications. Alternatively, existing biomechanical tools can simulate muscular forces and activations, but do not model changes in external shape, restricting how activations correlate with actual observable anatomy. This motivates a novel inverse research problem: recovering muscle deformations directly from visible surface observations - i.e., from the skin, and thus the pose. In this work, we present SOMA (from Surface Observations to Muscle Anatomy), a person-specific model that infers spatio-temporal muscle behavior from surface signals obtained using RGB cameras, and SKIM, a subject-specific soft-tissue deformation dataset. To the best of our knowledge, this is the first method that attempts to recover muscle deformations from multi-view RGB data. We show how our method provides anatomically grounded animations without the complexity of traditional simulations, leading to a scalable and cost-effective solution. Data and code are available.

Joint contact forces govern implant longevity, cartilage health, and rehabilitation outcomes, shaping who develops osteoarthritis, who recovers well from joint replacement, and who benefits from biomechanical interventions. Yet they remain measurable only invasively, in a few dozen patients with instrumented implants. I present a physics-free pipeline to predict instantaneous 3D hip and knee contact forces from an uncalibrated monocular video: no markers, force plates, electromyography, subject-specific imaging, or musculoskeletal model. Parametric body meshes are recovered per frame, encoded as kinematic features, and decoded into forces by a transformer whose pose stream is adaptively modulated at every layer by body shape, joint, side, activity text, and self-supervised video tokens (V-JEPA 2), unifying hip and knee in a single model. Under leave-one-subject-out cross-validation across 26 patients and 25 activity categories from the in vivo OrthoLoad database, the pipeline matches the accuracy of subject-specific musculoskeletal simulations ($0.32 \pm 0.08$ BW RMSE for hip; $0.23 \pm 0.03$ BW for knee) and resolves peak force changes smaller than those reported for gait retraining and osteoarthritis progression. Applied zero-shot to an independent instrumented cohort, it rivals or outperforms prior published methods. Even without curated activity labels, video features alone preserve accuracy and enable end-to-end inference on raw footage. Driven by the predictor, a generative motion prior produces biomechanically plausible variants with reduced peak loading, rediscovering strategies from the predictive simulation literature. This pipeline establishes uncalibrated monocular video as a viable modality for estimating joint loading, opening a path toward retrospective analysis of archived clinical recordings, primary-care screening, and at-home rehabilitation tracking.

Prosthetic socket fitting remains largely manual and iterative, and objective fit metrics are still limited. Part of the challenge is the lack of long-term real-life pressure data at the residual limb--socket interface. Traditional pressure sensors are prone to drift over time, and capture only normal pressures at sparse locations within the socket, missing a critical component for biomechanical analysis: shear. Although some sensors can report both normal and shear interface stresses, these components are often difficult to decouple because of measurement crosstalk. One potential path forward is to develop models that can augment available measurements. This work introduces a testbed to evaluate model performance under sparse pressure sensing using two complementary validation signals: (i) the global wrench (\ie, total forces and moments expressed in an orthonormal frame) transmitted through the socket, by an artificial residual-limb, and (ii) local interface loads (\ie, decoupled normal and shear pressure components in a right-hand-rule orthogonal frame that lives in each instrumented location) measured by sparse sensing clusters, each composed of four capacitance-sensing channels. Rather than presenting full-field pressure estimates, the focus is on an analysis sequence that quantifies how well candidate mechanical models explain both global and local measurements under controlled conditions. A quasi-static spring--mass contact model is evaluated, and its parameters are identified via a two-stage convex least-squares problem. Validation under static loading shows that estimating constant bias terms reduces steady offsets in the wrench channels and improves agreement with local measurements. A Pareto-front sensitivity analysis further illustrates how the trade-off between global and local objectives changes when bias terms are included.

Chronic pain diminishes quality of life by decreasing functional ability, yet objectively measuring this functional impact remains challenging in real-world settings. While optical motion capture provides high precision for assessing altered movement quality, it is costly and restricted to laboratory environments. We aimed to develop and validate Quantitative Movement Testing (QMT), a computer vision pipeline extracting 3D kinematic biomarkers from standard monocular smartphone video, balancing clinical accessibility with biomechanical accuracy. We validated the QMT pipeline, utilising deep learning-based 3D pose-estimation, against gold-standard optical motion capture in healthy controls (N=13). Following leave-one-subject-out calibration to correct systematic bias, we deployed QMT in two prospective clinical cohorts to assess real-world utility: a pre- and post-intervention trial for fibromyalgia patients, and a 30-day longitudinal at-home monitoring study of chronic sciatica patients and healthy controls. In laboratory validation, QMT extracted clinical kinematic metrics with high agreement to optical motion capture, yielding strong correlations (r > 0.85) and low mean absolute errors. QMT demonstrated high test-retest reliability (r > 0.86) in fibromyalgia patients and successfully tracked day-to-day movement fluctuations in chronic sciatica. While real-world home settings introduced higher measurement variance than lab settings, QMT found group-level differences between healthy controls and sciatica patients based entirely on remote recordings. Monocular 3D pose estimation offers a scalable alternative to traditional assessments. QMT provides an objective, accessible biomarker for tracking disease progression and treatment response in clinical trials, though further research is needed to optimise reliability in home environments.

Predicting patient-specific facial soft-tissue deformation is critical for iterative orthognathic surgery planning. However, current computational methods face a strict accuracy-efficiency trade-off: high-fidelity Finite Element Methods (FEM) are computationally prohibitive, whereas pure deep learning models often produce biomechanically inconsistent results. While Physics-Informed Neural Networks (PINNs) offer a promising avenue, learning the complex heterogeneous mechanics of bone--soft-tissue interactions with only partial clinical supervision (i.e., outer facial surfaces) remains highly unstable. To overcome these challenges, we present PINNOCHIO, a novel physics-informed framework for facial soft-tissue simulation. PINNOCHIO introduces a hybrid sequential decomposition that explicitly decouples discontinuous bone--soft-tissue interface movements from continuous volumetric hyperelastic deformation. This structural separation enables stable training and facilitates a physics-enabled sim-to-real adaptation strategy, ensuring internal biomechanical consistency without requiring volumetric ground truth. Evaluated on a 40-patient clinical cohort, PINNOCHIO outperforms existing baselines in both surface accuracy and physical validity. Furthermore, it achieves a substantial speedup over FEM, successfully resolving the accuracy-efficiency trade-off to provide a highly reliable and practical tool for interactive surgical planning.

The biological spine of quadrupeds enables sagittal flexion/extension, lateral bending, and axial rotation, playing a crucial role in highly agile and dexterous locomotion. While numerous studies have integrated active spinal joints into quadrupedal robots to enhance agility, most designs simplify control complexity by reducing spinal degrees of freedom (DOF), failing to achieve the spatial tri-axial rotation characteristic of biological spines. Consequently, replicating a multi-DOF biomimetic spine and effectively leveraging it to empower the agile locomotion of quadrupedal robots remains a significant research challenge. In this study, we present S-Cheetah, a quadrupedal robot featuring a 3-DOF bio-inspired serial active spine capable of biomimetic spatial tri-axial rotation. To empower the robot to fully utilize this active spine, we developed a specialized reinforcement learning framework to actively promote the engagement of the introduced spine and maximize the robot's locomotive capabilities by integrating an acceleration curriculum learning strategy with tailored reward functions, such as a gallop gait reward, a spine undulation reward, and a spine steering reward. Experimental results demonstrate that S-Cheetah can achieve a peak speed of 6.9 m/s using the rotary G2 gallop gait and an in-place turning rate of 7.2 rad/s. Besides, the system exhibits an emergent, feline-inspired aerial self-righting capability, allowing it to land stably on four feet from arbitrary orientations during free fall. Finally, through extensive evaluations across diverse locomotion tasks, we prove that the introduction of the proposed 3-DOF spine comprehensively enhances the locomotive agility of quadrupedal robots. Project website: himmy-robotics.github.io/scheetah

Co-speech gesture generation requires both semantic expressivity and biomechanically plausible rhythmic motion. Existing holistic gesture models mix lexically grounded semantic gestures with frequent prosody-aligned beat gestures. This limits semantic grounding, speech-motion alignment, and kinematic smoothness. We propose \emph{DuoGesture}, a neuro-inspired and biomechanically informed approach that decomposes co-speech gesture synthesis into semantic and beat streams. The two streams are coordinated by a \emph{Semantic Variational Information Bottleneck}, a stochastic frame-level gate that learns when semantic gestures should override rhythmic beat motion. The semantic stream is controlled by \emph{Motion-Grounded Semantic Conditioning}, which replaces purely linguistic word embeddings with motion-language representations to provide motion-aligned semantic priors for long-tailed lexical triggers of gestures. The beat stream is further regularised by an \emph{Inertial Beat Prior}, an anthropometry-weighted arm-chain module that reduces jitter and improves rhythmic consistency without constraining semantic frames. Objective evaluations and subjective experiments show that DuoGesture outperforms strong baselines, while component ablations confirm the complementary roles of semantic grounding, stochastic stream selection, and biomechanical regularisation.

Accurately reconstructing full-body poses from sparse head and hand trajectories is a foundational challenge for immersive AR/VR telepresence. Current methods often struggle with error accumulation and unnatural joint coordination, primarily because they treat the human body as a monolithic entity, thereby failing to capture the fine-grained ``atomic intents'' embedded in subtle signal variations and overlooking the inherent structural topology. To bridge this gap, we present AtomicMotion, a framework designed to decouple and re-integrate body dynamics through three core innovations. First, we introduce a logical body partitioning scheme that decomposes the skeleton into five distinct clusters based on functional intent; this ensures that each partition preserves internal joint synergies while isolating local motion primitives. Second, to robustly map sparse inputs to high-dimensional poses, we employ a masked full-body pre-conditioning strategy during training, forcing the model to internalize global skeletal topology and latent kinematic constraints. Finally, addressing the limitations of vanilla spatial attention, which often ignores fixed physiological connectivity, we propose Kinematic Attention. By embedding the classical kinematic tree structure into the attention mechanism, we ensure biological plausibility in the synthesized motions. Extensive evaluations on the AMASS dataset demonstrate that AtomicMotion significantly outperforms existing baselines, yielding higher reconstruction fidelity and superior biomechanical realism.

Parametric human models capture global pose but cannot represent the non-rigid surface dynamics of clothing and soft tissue. Generic scene flow estimates dense motion but breaks down on articulated bodies, where pixel-level supervision is also intractable to acquire. We introduce H-Flow, a dense human scene flow that captures both skeletal kinematics and surface deformation. A unified multi-head transformer estimates flow from monocular video, jointly predicting pose and depth as companion outputs. The challenge lies in the lack of supervision. In place of unattainable labels, we anchor the network in the physics of human motion, encoding geometric, structural, and biomechanical priors as cross-modal training objectives. We further introduce DynAct4D, a high-fidelity synthetic benchmark providing dense flow annotations across diverse subjects, garments, and motions. On standard benchmarks, H-Flow outperforms scene-flow and parametric baselines, and generalizes zero-shot to in-the-wild video. Code, models, and the DynAct4D benchmark will be released upon publication

arly identification of motor impairment in infancy relies on expert visual assessment of spontaneous movement, motivating the development of automated, objective alternatives. One promising approach is using computer vision, which benefits from high quality pose estimation from video. In this study, we systematically evaluated three state-of-the-art pose estimation frameworks (MeTRAbs-ACAE, SAM 3D Body, and Sapiens) on 100 videos over 13 sessions of 8 infants recorded with a multi-view markerless motion capture system. We quantified keypoint detection accuracy using reprojection error, geometric consistency, and Procrustes-aligned 3D position error, and demonstrated proof-of-concept for fitting an inverse kinematic framework to infant data. While Sapiens achieved the lowest reprojection error and highest geometric consistency of the methods evaluated (22.8 pixels and 0.82, respectively), SAM 3D Body provided the most comprehensive 3D information for kinematic reconstruction with Procrustes-aligned position errors of 19 to 28 mm. We demonstrate in a case comparison example that biomechanical models fit to SAM 3D estimates distinguish representative movement patterns in infants related to motor development, as identified by a clinical expert. Together, these findings highlight both the promise and current limitations of 3D pose estimation for infant biomechanics and establish preliminary groundwork for scalable, video-based assessment of early motor development.

Accurate segmentation and statistical shape modeling of hand anatomy have significant implications for medical diagnostics, ergonomics, and biomechanics. This study proposes an AI-assisted reconstruction pipeline for segmenting and analyzing hand anatomy from 1,271 elbow-to-hand (e2h-CT) computed tomography scans. A Pix2Pix-based conditional generative adversarial network is first employed to remove plaster cast and background artifacts from CT volumes. The cleaned scans are then processed in 3D Slicer to extract skin and bone masks, which are converted into closed-surface mesh models. Segmented bone meshes are used to construct skeletal representations, enabling implicit skinning to align all hand models into a standardized anatomical configuration. Subsequently, non-rigid registration is performed on the hand skin surfaces using the Geodesic Based Coherent Point Drift++ (GBCPD++) algorithm to establish point-wise correspondence across subjects. Principal Component Analysis (PCA) is then applied to the registered models to quantify anatomical shape variability. The Pix2Pix preprocessing stage achieved a Dice coefficient of 0.9856 and an IoU of 0.9720 on the held-out test set. Statistical modeling was performed on a subset of 90 scans in which the fingers were fully visible and anatomically separated. The resulting statistical shape distributions demonstrate strong agreement with the U.S. Army Anthropometric Survey (ANSUR II), supporting the anatomical validity of the reconstructed models. The proposed methodology demonstrates significant potential for advancing biomechanical modeling, ergonomic optimization, prosthetic design, and precision medical diagnostics.

Understanding adaptive biomechanical systems requires distinguishing observable performance, static multivariate representation, longitudinal displacement, and internal approximation of observed change. This study introduces Level 5, which examines whether the M1-M2 transformation observed in a single-subject gait dataset can be approximated within a selected PCA representation. Gait was recorded with instrumented insoles in a participant with Parkinson's disease under six occlusal observational probes during two sessions eleven weeks apart. A simplified feed-forward neural network was trained to approximate M2 PC1-PC2 coordinates from M1 coordinates, occlusal-probe descriptors, and the longitudinal-transition indicator. In the core analysis aligned with Level 4, the model preserved the Euclidean centroid-displacement hierarchy dOC3 < dONL < dOC2.5. In the extended six-probe analysis, it preserved the broad structure of the exploratory ordering. Held-out M2 and leave-condition-out analyses provided internal tests beyond the full-dataset fit, while a within-session analysis described probe positions relative to ONL. The term predictive is used only in a restricted methodological sense. The model does not provide prospective clinical prediction, patient-level forecasting, or generalization to unseen individuals. Occlusal conditions are treated as observational probes applied during measurement, not as continuous causal drivers of longitudinal evolution. The findings are exploratory, retrospective, representation dependent, and non causal. They do not establish causal occlusal effects, validated viability thresholds, therapeutic superiority, distinct physiological states, or generalizable predictive validity.

Understanding human motion beyond surface kinematics is crucial for motion analysis, rehabilitation, and injury risk assessment. However, progress in this domain is limited by the lack of large-scale datasets with biomechanical annotations, and by existing approaches that cannot directly infer internal biomechanical states from visual observations. In this paper, we introduce a simulation-based framework for estimating muscle activations from existing motion capture datasets, resulting in BioHuman10M, a large-scale dataset with synchronized video, motion, and activations. Building on BioHuman10M, we propose BioHuman, an end-to-end model that takes monocular video as input and jointly predicts human motion and muscle activations, effectively bridging visual observations and internal biomechanical states. Extensive experiments demonstrate that BioHuman enables accurate reconstruction of both kinematic motion and muscle activity, and generalizes across diverse subjects and motions. We believe our approach establishes a new benchmark for video-based biomechanical understanding and opens up new possibilities for physically grounded human modeling.

Accurate hand and finger tracking from video has significant clinical applications for monitoring activities of daily living and measuring range of motion, yet monocular video approaches for obtaining hand biomechanics remain under-developed. We present a method that combines the SAM 3D Body foundation model with inverse kinematics optimization in a full-body biomechanical model to extract anatomically-constrained finger joint angles from single-view video. We port SAM 3D Body from PyTorch to JAX for integration with MuJoCo-MJX, enabling GPU-accelerated optimization, and develop a novel mapping between the Momentum Human Rig (MHR) outputs and biomechanical model markers. Validation against 8-camera multiview reconstruction on 4,590 frames from 7 participants performing a variety of hand poses and object manipulation tasks shows finger joint angle errors of approximately 10 degrees and hand position errors of approximately 6 mm, after Procrustes alignment. Results were consistent across camera viewpoints and robust to different methods for producing reference values from multiview video. This work extends monocular biomechanical analysis to detailed finger tracking, expanding access to quantitative characterization of hand movement from readily available video.

Recent advances in model architectures, compute, and data scale have driven rapid progress in video generation, producing increasingly realistic content. Yet, no prior method systematically measures how faithfully these systems render human bodies and motion dynamics. In this paper, we present HumanScore, a systematic framework to evaluate the quality of human motions in AI-generated videos. HumanScore defines six interpretable metrics spanning kinematic plausibility, temporal stability, and biomechanical consistency, enabling fine-grained diagnosis beyond visual realism alone. Through carefully designed prompts, we elicit a diverse set of movements at varying intensities and evaluate videos generated by thirteen state-of-the-art models. Our analysis reveals consistent gaps between perceptual plausibility and motion biomechanical fidelity, identifies recurrent failure modes (e.g., temporal jitter, anatomically implausible poses, and motion drift), and produces robust model rankings from quantitative and physically meaningful criteria.

Existing lip-sync deepfake detectors rely on pixel artifacts or audio-visual correspondence, and both fail under generator or language shift because the features they learn are tied to the training distribution. We take a different approach. Authentic lip motion is constrained by tissue mechanics and neuromuscular bandwidth; current generators typically do not impose these constraints, producing trajectories with elevated variance in velocity, acceleration, and jerk that real speech does not exhibit. We exploit this signal, which we term temporal lip jitter, by computing kinematic statistics from 64 perioral landmarks over short sliding windows and feeding them into a lightweight three-branch network. The model uses only landmark coordinates: no pixels, no audio, and no voiceprint data. We train only on English data and test in a zero-shot setting on five unseen generators and seven languages.

Markerless 3D movement analysis from monocular video enables accessible biomechanical assessment in clinical and sports settings. However, most research-grade pipelines rely on GPU acceleration, limiting deployment on consumer-grade hardware and in low-resource environments. In this work, we optimize a monocular 3D biomechanics pipeline derived from the MonocularBiomechanics framework for efficient CPU-only execution. Through profiling-driven system optimization, including model initialization restructuring, elimination of disk I/O serialization, and improved CPU parallelization. Experiments on a consumer workstation (AMD Ryzen 7 9700X CPU) show a 2.47x increase in processing throughput and a 59.6% reduction in total runtime, with initialization latency reduced by 4.6x. Despite these changes, biomechanical outputs remain highly consistent with the baseline implementation (mean joint-angle deviation 0.35$^\circ$, $r=0.998$). These results demonstrate that research-grade vision-based biomechanics pipelines can be deployed on commodity CPU hardware for scalable movement assessment.

Reinforcement learning (RL)-based biomechanical simulations have the potential to revolutionise HCI research and interaction design, but currently lack usability and interpretability. Using the Human Action Cycle as a design lens, we identify key limitations of biomechanical RL frameworks and develop MyoInteract, a novel framework for fast prototyping of biomechanical HCI tasks. MyoInteract allows designers to setup tasks, user models, and training parameters from an easy-to-use GUI within minutes. It trains and evaluates muscle-actuated simulated users within minutes, reducing training times by up to 98%. A workshop study with 12 interaction designers revealed that MyoInteract allowed novices in biomechanical RL to successfully setup, train, and assess goal-directed user movements within a single session. By transforming biomechanical RL from a days-long expert task into an accessible hour-long workflow, this work significantly lowers barriers to entry and accelerates iteration cycles in HCI biomechanics research.

Accurate compensation of brain deformation is critical for reliable image-guided neurosurgery. Surgical manipulation and tumor resection induce tissue motion, causing preoperative planning images to become misaligned with the intraoperative anatomy. In this systematic review, we examine data-driven methods developed between 2020 and 2025 for brain deformation registration and modeling, with a particular focus on learning-based approaches. A comprehensive literature search was conducted in PubMed, IEEE Xplore, Scopus, and Web of Science using predefined inclusion and exclusion criteria for computational methods addressing brain deformation in neurosurgical imaging, resulting in 46 eligible studies. We provide a unified analysis of methodological strategies, including deep learning-based image registration, direct deformation field regression, synthesis-driven multimodal alignment, resection-aware architectures for handling missing correspondences, and hybrid models integrating biomechanical priors. We also examine dataset utilization, evaluation metrics, validation protocols, and the assessment of uncertainty and generalization across studies. While learning-based methods demonstrate promising accuracy and computational efficiency, current approaches remain limited by out-of-distribution robustness, standardized benchmarking, interpretability, and readiness for clinical deployment. Our review highlights these gaps and outlines future directions toward more robust, generalizable, and clinically translatable solutions for neurosurgical guidance. By organizing recent advances and critically assessing evaluation practices, this work provides a comprehensive reference for researchers and clinicians working on data-driven registration and modeling of brain deformation.

Parametric 3D human models such as SMPL have driven significant advances in human pose and shape estimation, yet their simplified kinematics limit biomechanical realism. The recently proposed SKEL model addresses this limitation by re-rigging SMPL with an anatomically accurate skeleton. However, estimating SKEL parameters directly remains challenging due to limited training data, perspective ambiguities, and the inherent complexity of human articulation. We introduce SKEL-CF, a coarse-to-fine framework for SKEL parameter estimation. SKEL-CF employs a transformer-based encoder-decoder architecture, where the encoder predicts coarse camera and SKEL parameters, and the decoder progressively refines them in successive layers. To ensure anatomically consistent supervision, we convert the existing SMPL-based dataset 4DHuman into a SKEL-aligned version, 4DHuman-SKEL, providing high-quality training data for SKEL estimation. In addition, to mitigate depth and scale ambiguities, we explicitly incorporate camera modeling into the SKEL-CF pipeline and demonstrate its importance across diverse viewpoints. Extensive experiments validate the effectiveness of the proposed design. On the challenging MOYO dataset, SKEL-CF achieves 85.0 MPJPE / 51.4 PA-MPJPE, significantly outperforming the previous SKEL-based state-of-the-art HSMR (104.5 / 79.6). These results establish SKEL-CF as a scalable and anatomically faithful framework for human motion analysis, facilitating the use of computer vision techniques in biomechanics-related analysis. Our implementation is available on the project page: https://pokerman8.github.io/SKEL-CF/.

Reconstructing biomechanically realistic 3D human motion - recovering both kinematics (motion) and kinetics (forces) - is a critical challenge. While marker-based systems are lab-bound and slow, popular monocular methods use oversimplified, anatomically inaccurate models (e.g., SMPL) and ignore physics, fundamentally limiting their biomechanical fidelity. In this work, we introduce MonoMSK, a hybrid framework that bridges data-driven learning and physics-based simulation for biomechanically realistic 3D human motion estimation from monocular video. MonoMSK jointly recovers both kinematics (motions) and kinetics (forces and torques) through an anatomically accurate musculoskeletal model. By integrating transformer-based inverse dynamics with differentiable forward kinematics and dynamics layers governed by ODE-based simulation, MonoMSK establishes a physics-regulated inverse-forward loop that enforces biomechanical causality and physical plausibility. A novel forward-inverse consistency loss further aligns motion reconstruction with the underlying kinetic reasoning. Experiments on BML-MoVi, BEDLAM, and OpenCap show that MonoMSK significantly outperforms state-of-the-art methods in kinematic accuracy, while for the first time enabling precise monocular kinetics estimation.

Markerless motion tracking has advanced rapidly in the past 10 years and currently offers powerful opportunities for behavioural, clinical, and biomechanical research. While several specialised toolkits provide high performance for specific tasks, using existing tools still requires substantial technical expertise. There remains a gap in accessible, integrated solutions that deliver sufficient tracking for non-experts across diverse settings. TrackStudio was developed to address this gap by combining established open-source tools into a single, modular, GUI-based pipeline that works out of the box. It provides video recording preprocessing, recording synchronisation, automatic 2D and 3D pose estimation, and visualisation without requiring any programming skills. We supply a user guide with practical advice for video acquisition, camera calibration, video synchronisation, and experimental setup, alongside documentation of common pitfalls and how to avoid them. To validate the toolkit, we tested its performance across three environments using either low-cost webcams or high-resolution cameras, including challenging conditions for body position, lighting, space, and obstructions. Across 76 participants, average inter-frame correlations exceeded 0.98 and average triangulation errors remained low (<13.6mm for hand tracking), demonstrating stable and consistent tracking. We further show that the same pipeline can be extended beyond hand tracking to other body and face regions. TrackStudio provides a practical, accessible route into markerless tracking for researchers or laypeople who need reliable performance without specialist expertise.

Human manipulation skills represent a pinnacle of voluntary motor functions, requiring the coordination of many degrees of freedom and the processing of high-dimensional sensor input to achieve remarkable dexterity. Thus, this study investigates whether the human hand, with its associated biomechanical properties, sensors, and control mechanisms, is an ideal that should be strived for in robotics. Do robots need anthropomorphic hands? First, characteristics of the human hand in terms of biomechanics and perception are extracted to compare them with currently commercially available robotic hands. From this comparison, research questions are derived that connect manipulation system complexity to skill repertoire size and dexterity. These questions are addressed through a systematic literature review, analyzing the manipulation capabilities demonstrated in 125 papers published between 2019 and 2025. Although complex five-fingered hands are often considered the ultimate goal for robotic manipulators, they are not necessary for all tasks. Findings indicate that in-hand manipulation does not benefit from anthropomorphic hand design, as simpler mechanisms are sufficient; however, mechanism complexity correlates with the breadth of manipulation tasks a hand can perform. Sensor integration and intelligent manipulation strategies remain underexplored, which may be due to a misalignment with hand design: instead of replicating the number of fingers and degrees of freedom, focusing on robustness and softness would allow more intelligent control and learning to exploit environmental contacts and integrate more sensors. Finally, the article argues for standardized evaluation criteria to enable the systematic comparison of hand designs and manipulation systems.