Diagnosis

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31 papers in the last four weeks, down 11% on the four weeks before. 0.4% of all new papers.

Jul 6Week of Sep 21

Latest papers 284

Jun 2, 2026cs.MA

MeDxAgent: Multi-Agent Consultation for Interactive Medical Diagnosis

Large language models (LLMs) are increasingly used for health-related decision support. Yet most evaluations treat diagnosis as a single-shot task with complete information provided upfront, often as a multiple-choice selection. This diverges from clinical practice, where diagnosis is interactive and open-ended, involving sequential hypothesis refinement through targeted questioning. We address this gap. We build MeDxBench, a large-scale benchmark of 4,421 clinical cases across 20 specialties. We further propose MeDxAgent, a multi-agent consultation system for interactive diagnosis, and systematically study its prompt-, flow- and agent-level design choices. MeDxAgent achieves a 10.3% accuracy gain over the baseline on MeDxBench, closing 52.3% of the gap to a full-information oracle. We find that specific design choices: collecting demographics first, passing summarized dialogue for diagnosis, and feeding candidate diagnoses for targeted questioning, improve accuracy, mirroring how physicians reason, though their effect emerges fully only in combination. Code and dataset will be released upon publication.

Akshat Sanghvi, Naren Akash, Raza Imam +2

Microsoft Research India · Institute of AI and Innovation, AIG Hospitals · Mohamed bin Zayed University of Artificial Intelligence

Diagnosis Multiple-Choice Questions

Jun 1, 2026cs.CV

Diagnosis of Human Object Interaction Detectors for Real World Educational Applications

Human-object interaction (HOI) recognition is critical for automatically analyzing student behavior in complex educational environments. Although state-of-the-art (SOTA) HOI detectors perform well on benchmark datasets, their performance often degrades when deployed in real-world training environments due to domain-specific objects, occlusions, and complex visual conditions. In this paper, we introduce a diagnosis-driven framework that integrates a triplet-level HOI error taxonomy with error-factor attribution analysis for real-world educational video data. We study this problem in the context of Critical Care Air Transport Team (CCATT) mixed-reality medical training. Based on an analysis of HOI failure modes and their causes, we develop a diagnosis-informed refinement strategy for adapting pretrained HOI models to the target domain. Experiments on the CCATT dataset show that this approach improves the macro-F1 score of a pretrained CDN model from 48.6 to 90.2 through targeted refinement guided by diagnosed error factors. These results highlight the value of detailed diagnostic analysis for informing targeted adaptation of HOI models in real-world educational environments.

Divya Mereddy, Ashwin Tudur Sadashiva, Marcos Quinones-Grueiro +1

Vanderbilt University Nashville, TN, USA

Articulated Objects Diagnosis

Jun 1, 2026cs.CV

FairGen: Preference-Aligned Diffusion for Demographically Equitable Medical Image Synthesis

Medical imaging is central to modern diagnostics, and artificial intelligence (AI) systems are increasingly used to support image-based analysis by improving efficiency, accuracy, and access to care. However, inequities in healthcare access and differential disease prevalence create severe demographic imbalances in clinical image data. Such imbalances are compounded by the fact that diseases can manifest with distinct features across demographic groups, rendering certain phenotypic presentations naturally rare. AI models trained on such imbalanced data risk perpetuating diagnostic bias and widening healthcare disparities. Here we introduce FairGen, a fairness-aware diffusion framework that synthesizes demographically balanced medical images while preserving pathology-relevant visual features. By embedding physician-aligned preferences into the generation process, FairGen improves subgroup coverage during synthesis and downstream classification. Applied to dermatology, radiology, and neuroimaging benchmark tasks, FairGen achieves fairness improvements of 95.9% for skin images, 80.0% for chest radiography, and 35.2% for brain MRI, while maintaining competitive diagnostic accuracy relative to models trained on original clinical data. Clinician-facing expert review and external validation on independent cohorts further support that these gains extend beyond standard fidelity metrics and are not confined to the original in-distribution datasets.

Zhimin Li, Ruichen Zhang, Zhen Tan +3

University of Pittsburgh, Swanson School of Engineering, Pittsburgh, 15261, USA · 2The University of North Carolina at Chapel Hill, Department of Computer Science, Chapel Hill, 27599, USA · 3Arizona State University, School of Computing and Augmented Intelligence, Tempe, 85281, USA +1

Medical Image Generation Diffusion Alignment Diffusion Models Diagnosis Synthesis

Jun 1, 2026cs.CV

PerBite: A Curated Diagnostic Workflow for Bite-Aware Food Volume Estimation

Can a visually plausible food mesh be trusted to estimate the volume of consumed food? \method investigates this question using selected paired before- and after-consumption states from the MetaFood CVPR 2026 Continuous 3D Reconstruction While Eating Challenge. The submitted workflow follows a curated reconstruction protocol: SAM~~3 segments the food and plate regions; Hunyuan3D/SAM~~3D generates a dimensionless food mesh; the plate diameter provides the metric scale; the plate geometry is removed in Blender; and the remaining mesh is hole-filled, made watertight, and integrated to estimate volume. MoGe-2 is used only as an auxiliary cue for initial dish-diameter estimation when direct plate measurement is uncertain; it is not the primary scale source for the reported challenge result. \method ranks first, with an average Chamfer distance of 8.31 across 34 meshes using rigid ICP without scale correction. On 17 before- and after-pairs, it achieves 33.87% state-level volume MAPE and zero monotonicity violations, while consumed-volume MAPE remains 53.74%. The results show that surface reconstruction, metric scale, controlled mesh cleanup, watertight volume integration, and physical depletion consistency should be evaluated separately for dietary assessment. Source code and evaluation scripts will be available at \href{https://github.com/GCVCG/PerBite-CVPR-MetaFood-2026}{github.com/GCVCG/PerBite-CVPR-MetaFood-2026}.

Ahmad AlMughrabi, Farid Al-Areqi, David Fernández Gómez +4

1Universitat de Barcelona, Spain. · 4LogMeal, AIGecko Technologies S.L. · 2Grup de Tecnologies Interactives, Universitat Pompeu Fabra, Spain. +1

Diet Volume Recipe Mean Squared Error Meta Diagnosis

Jun 1, 2026cs.CV

Learning Label-Efficient Interpretable Medical Image Diagnosis via Semi-supervised Hypergraph Concept Bottleneck Model

Deep learning has revolutionized medical image analysis, delivering exceptional diagnostic accuracy across diverse applications. Yet, the lack of interpretability in its decision-making hinders clinical adoption, particularly in high-stakes medical contexts where transparency is paramount for trustworthiness. For example, in Placenta Accreta Spectrum (PAS), subtle cues in ultrasound imaging challenge reliable diagnosis, rendering black-box models untrustworthy for accurate scoring. To address this, Concept Bottleneck Models (CBMs) offer a promising avenue by embedding clinically meaningful intermediate concepts into the diagnosis pipeline, enabling clinicians to scrutinize and refine model outputs. However, conventional CBMs falter in capturing complex inter-concept dependencies and demand costly, expert-driven concept annotations, limiting their scalability. This study introduces a novel semi-supervised CBM framework designed for medical imaging, which leverages dual-level hypergraph learning to model high-order concept dependencies and generate domain-adaptive pseudo-labels. Our approach achieves superior interpretability and performance by integrating a concept-level hypergraph for enhanced reasoning and an image-level hypergraph for robust pseudo-label generation. Experiments on a newly annotated PAS ultrasound dataset and a breast ultrasound public dataset demonstrate the effectiveness of the proposed concept label-efficient interpretable framework. Its universality is further validated on the dermoscopic image dataset SkinCon. The code is available at https://github.com/scott-yjyang/HyperCBM.

Yijun Yang, Ruiqiang Xiao, Lijie Hu +4

HKUST(GZ) · Joy Future Academy · MBZUAI +3

Multiple Instance Learning Label Propagation Concept Bottleneck Models Diagnosis Hypergraphs Bottlenecks

May 31, 2026cs.AI

Brain-Atlas-Guided Generative Counterfactual Attention for Explainable Cognitive Decline Diagnosis Using Multimodal Connectomes

Mild cognitive impairment (MCI) and subjective cognitive decline (SCD) are closely associated with the early Alzheimer's disease continuum, where accurate and explainable diagnosis is important for early risk assessment and intervention. Existing connectome-based deep learning models can improve classification performance but often provide limited insight into disease-related functional and structural connectivity changes. This paper proposes an atlas-knowledge-guided Generative Counterfactual Attention-guided Network (GCAN) for explainable cognitive decline diagnosis using multimodal brain connectomes. GCAN formulates diagnosis as a source-to-target counterfactual generation problem, where target-label connectomes are generated from source-label inputs and their differences are used to construct counterfactual attention maps. To preserve connectome topology, an Atlas-aware Bidirectional Transformer (AABT) performs network-level token encoding and decoding under brain-atlas constraints. The framework is further extended from functional connectivity (FC) to joint functional and structural connectivity (SC) modeling, enabling counterfactual analysis of complementary functional reorganization and structural topology changes. Experiments on hospital-collected and ADNI datasets show that GCAN achieves competitive performance across HC vs. SCD, HC vs. MCI, and SCD vs. MCI classification tasks. Visualization, circular connectome analysis, CAM-based comparison, ablation studies, and confidence interval analysis further support the interpretability and reliability of the proposed framework. Modality-specific FC and SC pre-trained classifiers are used to provide target-state priors for counterfactual generation while being separated from the downstream diagnostic classifier to prevent data leakage.

Xiongri Shen, Jiaqi Wang, Zhenxi Song +5

Department of Computer Science and Technology, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055, China · School of Intelligence Science and Engineering, College of Artificial Intelligence, Harbin Institute of Technology, Shenzhen, 518055, China · School of Biomedical Engineering, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical, Measurements and Ultrasound Imaging, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China

Mild Cognitive Impairment Human Connectome Project Functional Connectivity Connectome Diagnosis Explainability

May 31, 2026cs.LG

A Per-Component Diagnostic Protocol for Neural HJB-PIDE Solvers under Control-Dependent Lévy Jumps

We propose a five-step diagnostic protocol for residual-trained neural HJB-PIDE solvers with control-dependent Lévy jumps, targeting a general failure mode of neural PDE methods: a learned solution can match headline scalar diagnostics while miscomputing an operator inside its training loss. The protocol pairs each neural solve with at least one from-scratch independent reference, decomposes the Hamiltonian into drift, diffusion, compensator, and nonlocal-integral components across a u-grid, and compares the value function and its low-order derivatives over a (t,x) grid before any argmax comparison. Applied to a standard CRRA-Merton-Variance-Gamma benchmark, it isolates a missing 1/2-mixture factor in the neural method's importance-proposal density that scaled the nonlocal integral by exactly half - a textbook signature of a constant proposal scale error, invisible to longer training, grid refinement, and truncation sweeps. With the bug corrected, four references - two finite-difference solvers with disjoint discretizations, the neural solver, and a semi-analytic scalar baseline obtained from CRRA homogeneity - agree on the optimal control to within ~2%. The constant-coefficient CRRA benchmark collapses by homogeneity to a scalar maximization, so the scalar baseline is the efficient method here; the contribution is the protocol, applicable in principle to non-homogeneous and higher-dimensional settings where neural HJB-PIDE solvers are genuinely needed. The episode is a concrete instance of a broader neural-PDE verification failure: pointwise agreement of a learned value or control can coexist with a systematically wrong nonlocal operator, so per-component and surface-level checks are needed before trusting the argmax policy.

R. Drissi

Neural Solvers Hamilton-Jacobi Reachability Stochastic Differential Equations Solvers Neural Network Verification Diagnosis+1

May 30, 2026cs.AI

PropLLM: Propagation-Aware Scene Reconstruction for Network Fault Diagnosis

Network faults propagate layer by layer along topology and protocol dependencies, yet operations systems typically observe only symptomatic alerts at the tail end of propagation chains, where distinct root-cause faults may produce highly similar end-point symptoms. Existing approaches, whether rule-based, machine learning (ML)-based, or large language model (LLM)-based, fundamentally map the alert set to a diagnosis in a single pass and are structurally incapable of resolving this end-point ambiguity. This paper proposes PropLLM, which is the first to integrate the hop-by-hop scene reconstruction paradigm with the generative reasoning capabilities of LLMs. Starting from end-point alerts, PropLLM traces back hop-by-hop along the propagation path, retrieving verifiable factual evidence from a dual-layer knowledge graph (KG) at each hop, while the proposed Temporal Causal Propagation Attention (TCPA) mechanism encodes known topological causal priors directly into the attention computation to guide the model along the correct causal direction, ultimately localizing the root cause and determining the fault type through a fully evidenced causal chain. On a real-world Wi-Fi multimodal fault dataset, PropLLM improves fault type diagnosis accuracy by 3.9% and root cause localization accuracy by 4.7% over the strongest baseline, while reducing the hallucination rate by 50.8%. Supplementary experiments on the TeleLogs 5G dataset further demonstrate the effectiveness of the proposed method across different network scenarios.

Zongzong Wu, Ming Zhao, Fengxiao Tang +1

School of Computer Science and Engineering, Central South University, Changsha, China · Graduate School of Information Sciences (GSIS), Tohoku University, Sendai, Japan

Root Cause Analysis Diagnosis Multimodal Dataset Scene Reconstruction Scene Understanding

May 29, 2026cs.IR

HyBIRD: Hyperbolic Bridge Retrieval and Diagnosis for Methodology Inspiration Retrieval

Methodology Inspiration Retrieval (MIR) asks a system to retrieve prior papers whose methods can inspire a new research proposal. Unlike general scientific retrieval, the central challenge is not topical similarity but whether a candidate paper provides concrete mechanisms that can instantiate an abstract methodological need. Existing MIR dense retrievers provide strong paper-level rankings, but the returned lists do not expose how proposal needs are bridged by retrieved methods, where evidence is weak, or which complementary snippets may help. We propose HyBIRD, a frozen-anchor framework that treats MIR as hyperbolic bridge retrieval and post-hoc method diagnosis. HyBIRD keeps a strong MIR dense retriever fixed, learns lightweight point, cone, and factorized hyperbolic bridge variants, and uses LLM-assisted method blocks for post-hoc explanation and evidence selection. On the MIR benchmark, the factorized bridge reaches 59.034 mAP while preserving the dense anchor's strong retrieval behavior. More importantly, HyBIRD converts ranked papers into inspectable query need profiles, factor coverage, maturity views, and complementary evidence bundles. The results suggest that hyperbolic geometry is most useful as calibrated structure over a dense anchor, rather than as a standalone replacement for dense retrieval.

Yang Yang, Boyun Xu, Hao Fu +6

The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China · Shandong University, Weihai Campus, 180 Wenhua West Road, Weihai, 264209, Shandong, P.R. China · Institute of Deep Perception Technology, JITRI, Wuxi 214000, China

Retrievers Missing Bridge Concept Bottleneck Models Diagnosis

May 28, 2026cs.CL

Same Patient, Different Words, Different Diagnosis? Evaluating Semantic Stability in Clinical LLMs

Large Language Models (LLMs) are increasingly used in clinical applications. However, their behavior remains highly sensitive to subtle linguistic variations, such as rephrasing or syntactic variation. This sensitivity poses risks in safety-critical healthcare settings, where semantically equivalent inputs should produce consistent predictions. However, a key challenge is to ensure that prompt variations truly preserve clinical meaning, as embedding-based similarity metrics often fail to capture distinctions involving negation, temporality, or severity. To address this limitation, we propose a semantic verification framework based on Natural Language Inference (NLI) to filter meaning-preserving prompt variations, which are further refined using an LLM-as-a-judge and audited by a clinical expert. In addition, we introduce three metrics to quantify model sensitivity: MeaningPreserving Variation Sensitivity (MVS), confidence variation (ΔC), and Worst-Case Instability (WCI). We evaluate 16 open-source general-purpose (GP) and medical LLMs within the same model families and parameter scales, using reformulated prompts derived from the DiagnosisQA and MedQA datasets. Our results demonstrate that robustness differences between domain-specific (DS) models are mixed and highly model-dependent, i.e., domain specialization does not consistently improve or reduce robustness to meaning-preserving prompt reformulations. Several DS models rank among the most robust (when compared with GP counterparts), and strong GP baselines remain competitive as well.

Mahdi Alkaeed, Adnan Qayyum, Nabeel Abo Kashreef +2

Department of Computer Science and Engineering, College of Engineering, Qatar University, Doha, Qatar · College of Science and Engineering, Hamad Bin Khalifa University (HBKU), Doha, Qatar · Primary Health Care Corporation (PHCC), Doha, Qatar +1

Clinical Diagnosis

May 28, 2026cs.CL

MedCase-Structured: A Text-to-FHIR Dataset for Benchmarking Diagnostic Reasoning in Clinically Realistic EHR Settings

Large language models (LLMs) show promise for clinical reasoning and decision support, but evaluation in structured, electronic health record-congruent settings remains limited. Existing benchmarks often rely on static datasets or unstructured inputs that do not reflect the interoperable data formats used in clinical systems. We introduce a reusable pipeline for generating terminology-grounded HL7 FHIR R4 bundles from unstructured text, enabling controllable evaluation of clinical decision support systems over structured inputs. The pipeline combines staged LLM generation with terminology-grounded validation and repair to eliminate hallucinated codes and enforce structural and semantic consistency. Applying this approach to MedCaseReasoning, we construct MedCase-Structured, a synthetic dataset of 1,732 FHIR bundles derived from clinician-authored diagnostic cases, producing complete, valid bundles for 97.1% of attempted cases. Evaluation on MedCase-Structured reveals consistently lower diagnostic accuracy for LLMs on structured FHIR inputs than with plain text, highlighting the importance of deployment-aligned benchmarking.

Valentina Bui Muti, Eugénie Dulout, Ziquan Fu

System Inc., New York, NY, USA.

Clinical Reasoning Training Clinical Decision Support Electronic Health Records Diagnostic Benchmark Clinical Diagnosis

May 28, 2026cs.AI

NICE: A Theory-Grounded Diagnostic Benchmark for Social Intelligence of LLMs

As large language models (LLMs) are increasingly applied in social contexts such as emotional companionship and customer service, measuring their social intelligence has become critical to the quality and safety of human-AI interaction. However, existing social intelligence benchmarks lack a unified framework that organizes social abilities into a unified structure, and therefore cannot enable fine-grained diagnosis. To build the first holistic diagnostic evaluation grounded in social theory, we first construct a social intelligence framework through a literature review and multi-stage expert validation guided by psychometric principles. The resulting framework includes 4 categories and 11 dimensions, each further specified by fine-grained capability facets. Building on this framework, we introduce NICE (Norm, Interaction, Cognition, Experience), a diagnostic benchmark of 137 items operationalized through representative Chinese contexts. Across 5 frontier LLMs and a human reference group, models score higher in aggregate accuracy yet show a consistent weakness in Communication, which the framework localizes to 3 specific capability facets: multi-turn communication, nonverbal communication, and synchrony. NICE thus reframes social intelligence evaluation toward theory-grounded diagnosis of socially consequential weaknesses in LLMs.

Yunjin Qi, Zhaojun Jiang, Xuan Wu +10

Department of Psychology and Behavioral Sciences, Zhejiang University · College of Artificial Intelligence, Zhejiang University · 3Human Machine Interaction Lab, Huawei Technologies Co., Ltd. +1

Diagnostic Benchmark Intelligence Diagnosis Nonverbal Cues

May 28, 2026cs.CV

An Approach for Thyroid Nodule Analysis Using Thermographic Images

Thyroid cancer is said to be the second most common type of cancer in female individuals and the third in males by 2030, according to projections. In general, detecting cancer in its early stages improves the chance of survival of the individual. Thermography is a diagnostic tool that has been increasingly used to detect cancer and abnormalities, including that of thyroid. Various methods to segment and detect hot regions in thermograms and, consequently, to detect suspicious tissues present in these images have been proposed. It is well known that medical diagnosis yields a great deal of information. Thus, physicians have to comprehensively analyse and evaluate this information in a short period of time, which is infeasible in most cases. In this work, we perform a general review of thermography , focusing on the thyroid analysis. We propose protocols for image acquisiton and an autonomous registration for thyroid images. We also perform analyses of the image data, which include feature extraction, image processing, and a possible approach for classification of healthy or unhealthy patients. In summary, this work presents a pilot project for detection of tumors in our university hospital, which is part of an effort to support preventive medical actions in our endocrinology department. Under some future adjustments, this project will be submitted for approval by the ethics and research committee of Hospital Universitário Antonio Pedro at Universidade Federal Fluminense (HUAP-UFF) and to the Brazilian Ministry of Health Ethical committee under the name: Evaluation of the importance of thermography to aid diagnosis of thyroid nodules of patients in HUAP-UFF (in Portuguese: Avaliação da importância da termografia no auxílio à investigação diagnóstica de nódulos tireoidianos em pacientes acompanhados no HUAP-UFF).

J. R. González, É. O. Rodrigues, C. P. Damião +6

Computer Science Department, Universidade Federal Fluminense, Av. Milton Tavares de Souzas, s/n—Boa Viagem, Niterói, RJ 24210-330, Brazil · Radiology Department, Hospital Universitário Antônio Pedro (HUAP), Av. Marquês do Paraná, 303, Niterói, RJ, Brazil · Applied Computation Group NCA-UFMA, Universidade Federal do Maranhão, Av. dos Portugueses, São Luís, 1966, MA, Brazil +2

Thermal Imaging Tumor Diagnosis

May 26, 2026cs.CL

Attribute-Based Diagnosis of LLM Alignment with Hate Speech Annotations

Hate speech annotation is costly, subjective, and prone to annotator disagreement, making large-scale dataset construction challenging. We systematically analyze how well large language models (LLMs) align with human judgments across ten theoretically grounded subjective attributes, such as dehumanization, violence, and sentiment, evaluating both small and large variants of Llama 3.1 and Qwen 2.5. Our analysis reveals a consistent split across all models: behaviorally explicit dimensions (insult, humiliate, attack-defend) correlate strongly with human annotations, while evaluative dimensions (respect, sentiment, hate speech) are systematically inverted. Demographic persona conditioning reduces model confidence without improving alignment. Building on these insights, we propose combining attribute-level LLM predictions via a confidence-weighted Ridge regression to reconstruct continuous hate speech scores from the Measuring Hate Speech corpus, achieving

R^2

of up to 0.71 and outperforming direct prompting baselines, demonstrating that structured attribute decomposition recovers a richer and more human-aligned signal than end-to-end label prediction alone.

Mohammad Amine Jradi, Faeze Ghorbanpour, Alexander Fraser

School of Computation, Information and Technology, TU Munich Munich Center for Machine Learning (MCML)

Hate Speech Detection Large Language Model Annotations Large Language Model Alignment Large Language Model Bias Hate Speech Sentiment+1

May 26, 2026cs.CL

Evidence Absence Is Not Evidence Insufficiency: Diagnosing NEI Construction Artifacts in Fact Verification

Evidence absence is not evidence insufficiency, but fact verification benchmarks can make them observationally similar. The Not Enough Information (NEI) label is often operationalized through constructed evidence conditions, and that choice silently determines what a verifier learns. We introduce NEI-CAP, a construction-aware diagnostic protocol for insufficient-evidence evaluation. Each NEI example carries the construction family that produced it; NEI-CAP audits shortcut cues, validates hard cases through human adjudication, and tests whether competence transfers across constructions. We instantiate the protocol on SciFact, with FEVER and HoVer as bounded external controls. Across these settings, NEI competence does not transfer reliably: encoder verifiers and an instruction-tuned decoder trained on shortcut-prone constructions fail to recognize semantically related insufficient evidence, and mixed-construction training narrows but does not close the gap. Fixed-claim diagnostics further show that the evidence condition shifts confidence in the reference Support/Refute label, not only NEI recall, so an aggregate NEI score can hide which problem a model has actually solved. We therefore recommend reporting the construction family alongside the score, and distill the results into a checklist for benchmarks that carry an insufficient-evidence label.

Jingxi Qiu, Zeyu Han, Cheng Huang

ZenWeave AI · Georgetown University

Incomplete Evidence Category-Aware Atomic Claims Diagnosis Construction Competence

May 26, 2026cs.CV

Clinically-Grounded Counterfactual Reasoning for Medical Video Diagnosis

Medical video diagnosis involves inferring clinical decisions from dynamic tissue responses throughout examination processes. Existing methods rely on an end-to-end learning paradigm that i) focuses on appearance rather than pathology, ii) lacks clinical priors, and iii) reasons solely from observations without counterfactual comparison. This work introduces MedVCR, a counterfactual reasoning framework that mimics clinical diagnostic thinking. MedVCR comprises three components: a Counterfactual Generator that synthesizes tissue evolution under specified pathological states via a diffusion-based manner; a Counterfactual Representation Learning module that encodes diagnostic knowledge through clinical rules (i.e., temporal consistency, pathological separability, and counterfactual alignment); and a Dual Diagnostic Prediction strategy that integrates video-level assessment with frame-level counterfactual analysis. MedVCR is evaluated under both fully supervised (e.g., colposcopy) and weakly supervised (e.g., colonoscopy) video diagnosis settings, yielding 2.6%-10.2% performance gains compared with leading baselines. Comprehensive ablation studies further validate the effectiveness of each component. The code will be released.

Jianzhe Gao, Churan Wang, Weiyi Zhang +5

Medical Visual Question Answering Diagnosis Tissue Separability

May 25, 2026cs.LG

Semigroup Consistency as a Diagnostic for Learned Physics Simulators

Learned physics simulators are often evaluated by one-step or short-horizon prediction error, but these metrics can miss failures in temporal composition and long-horizon rollout. For autonomous, state-complete systems, exact solution maps satisfy a semigroup law: direct evolution over

s+t

should agree with evolution over

s

followed by

t

. We propose normalized semigroup error as a post hoc, model-agnostic diagnostic comparing these direct and composed learned predictions. On one-dimensional heat and Burgers dynamics with time-conditioned ConvNet and FNO baselines, semigroup error is positively associated with rollout degradation, with trajectory-level Spearman correlation

ρ= 0.635

and

95%

CI

[0.621, 0.649]

. Semigroup regularization has mixed effects, supporting semigroup consistency primarily as an evaluation diagnostic rather than a universally beneficial training objective.

Lennon J. Shikhman

Georgia Institute of Technology

Physics Simulation Short-Horizon Forecasting Diagnosis Evolutionary Optimization Methods

May 25, 2026cs.CV

Context-driven Missing-Modality Learning for Robust Medical Diagnosis with Image-Tabular Data

While multimodal data integrating diverse imaging and clinical tabular records is crucial for accurate medical diagnosis, the arbitrary absence of specific modalities is prevalent in clinical practice, severely degrading the performance of multimodal models. Existing methods either discard missing modalities, leading to information loss, or struggle to synthesize them without capturing complex inter-modal dependencies. To address these limitations, we propose a novel Context-driven Missing-Modality Learning (CMML) framework, which sequentially performs modality synthesis and semantic alignment to achieve robust diagnosis under arbitrary missing conditions. Specifically, we design a Cascade Residual Transformer-based Autoencoder (CRTA) that leverages learnable context tokens acting as dataset-level semantic prior to capture inter-modal dependencies and synthesize key missing representations. These representations are further enriched by modality-specific memory banks. To resolve the discrepancy between original available and synthesized representations, we transform the learned context tokens into instance-adaptive semantic references by infusing multimodal representations from the CRTA's outputs. This reference guides the alignment of heterogeneous modality representations into a unified space, where class-aware contrastive refinement is finally applied to explore discriminative diagnostic cues. Extensive evaluations on skin lesion (Derm7pt), ocular disease (ODIR), and meningioma (MEN) datasets demonstrate that CMML significantly outperforms state-of-the-art (SOTA) methods, yielding AVG AUC improvements of 1.26%, 0.97%, and 1.32%, respectively.

Tianling Liu, Lequan Yu, Tong Han +1

College of Intelligence and Computing, Tianjin University, Tianjin 300350, China. · Department of Statistics and Actuarial Science, School of Computing and Data Science, The University of Hong Kong, Hong Kong. · Department of Radiology, Tianjin Huanhu Hospital, Tianjin 300350, China. +2

Multimodal Clinical Data Multimodal Learning Diagnosis Tabular Data Autoencoder Architectures

May 25, 2026cs.AI

Uncertainty Reasoning with Large Language Models for Explainable Disease Diagnosis

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the verifiability and interpretability essential for trustworthy medical AI. We propose a neuro-symbolic reasoning framework that aligns LLMs with formal logic to enable explainable and formally verifiable medical diagnosis. Patient descriptions and clinical guidelines are embedded into a neural knowledge base, where LLMs extract structured medical entities, temporal relations, and fuzzy symptom patterns, which are decoded into a symbolic knowledge base expressed in fuzzy logic and declarative rules. We perform two-stage reasoning: (1) inductive symbolic generalization to capture diagnostic patterns from encoded narratives, and (2) inference verification via a logic programming engine to derive and validate diagnoses consistent with clinical standards. Each symptom is treated as a fuzzy predicate with probabilistic weights, and inference paths are auditable, adjustable, and compatible with physician feedback. Unlike purely statistical methods, our system supports iterative refinement: misalignment between LLM-generated diagnoses and ground truth can be traced, explained, and corrected through formal rules. By combining logic-based transparency, LLM adaptability, and probabilistic robustness, the framework enables human-aligned healthcare inference with strong generalization and verifiable, step-by-step reasoning chains. We validate our framework on public benchmarks, demonstrating effective reconciliation of symbolic reasoning and LLMs with real-world clinical narratives. Results show performance comparable to state-of-the-art LLMs, while additionally providing interpretable reasoning paths and formally verifiable diagnostic conclusions.

Xiaoyang Fan, Yufan Cai, Zhe Hou +1

National University of Singapore · Griffith University

LLM Reasoning Strategies Diagnosis Neuro-Symbolic Framework Uncertainty

May 25, 2026cs.LG

Relative Repairability: A Calibration-Based Diagnostic for High-Sparsity Post-Pruning Allocation

At very high sparsity, neural network pruning does more than decide which weights remain. It also determines where pruning induced damage is placed across the network, and whether that damage can be recovered by a fixed lightweight repair procedure. We study this problem through the lens of repair conditioned sparsity allocation. We introduce Relative Repairability (RR), a calibration based diagnostic that compares the raw activation distortion caused by layerwise pruning with the residual distortion left after channelwise variance matching repair. RR estimates the fraction of local damage that remains after repair, using only unlabeled calibration data. Across ResNet18, ResNet34, and VGG16 BN on CIFAR10 and CIFAR100, we find that RR is not a universally dominant allocation rule. Instead, it is most useful near an architecture dependent recoverability transition, where standard structural or magnitude based allocation priors begin to lose reliability but post repair recovery has not yet fully collapsed. On CIFAR100 ResNet18, a fine grained sweep shows that RR improves over ERK across the central transition band and surpasses LAMP near the upper part of this band. A projection forced ablation further shows that capped ERK can over protect projection layers, shifting excessive sparsity onto regular convolutions and reducing post repair recovery. These results suggest that high sparsity pruning should allocate not only retained weights, but also repairable damage.

Qishi Zhan, Liang He, Minxuan Hu +1

Marquette University · Tongji University · Cornell University +1

Sparsity Resnet-18 Distortion Diagnosis

May 24, 2026eess.IV

Methodology for Creating a Clinically Verified Dermoscopic Image Dataset

This study presents a methodology for constructing a clinically verified dataset of dermatoscopic images for medical informatics research. The relevance of the work is driven by the fact that the performance of automated diagnostic support systems depends not only on the volume of images, but also on the reproducibility of the image acquisition procedure, the completeness of structured metadata, and the reliability of diagnostic labels. International collections were primarily created under conditions that differ substantially from routine Russian outpatient practice and mobile dermatoscopy. The proposed methodology integrates three interconnected components: (1) a standard operating procedure (SOP) for acquiring images via mobile dermatoscopy, (2) an information model comprising 16 structured metadata fields organized into six clinically oriented blocks in ISIC-compatible notation, and (3) a multi-stage expert verification of diagnostic labels (initial clinical annotation, consensus review by three specialists, and histological confirmation of all malignant neoplasms). Using this methodology, a dataset of 1,026 unique dermatoscopic images from 443 patients was collected between June 2025 and May 2026. From 1,044 initial records, 18 duplicates were excluded. The dataset includes nine nosological categories; all 39 malignant lesions (18 melanomas, 15 basal cell carcinomas, and 6 squamous cell carcinomas) were histologically verified. Patient age ranged from 2 to 90 years (median 38), with 279 females (63%) and 164 males (37%). Each image is accompanied by expert-annotated dermatoscopic structures and an explicit verification_stage field indicating the level of diagnostic confirmation. The resulting dataset serves as a pilot clinically verified resource suitable for independent model evaluation, domain shift analysis, interpretability studies, and further expansion.

Kozachok Elena Sergeevna

Ivannikov Institute for System Programming of RAS, Moscow, Russia

Skin Lesion Classification Medical Imaging Datasets Diagnosis Methodology

May 23, 2026cs.CL

WhenLoss: Diagnosing Write and Retrieval Bottlenecks in Long-Context Memory Systems

Long-context memory systems often fail under fixed budgets, but end-to-end evaluation does not reveal whether evidence was discarded during compression or preserved but never retrieved. We introduce a four-condition diagnostic protocol that evaluates a fixed reader under truncated full context (TFC), oracle evidence (OE), complete stored memory (CSM), and retrieved memory (RM). Under this fixed-budget LongMemEval setup, write-side gaps exceed retrieval-side gaps for most tested baselines, with four of six baselines robustly write-dominant under our default diagnosis margin. Motivated by this diagnosis, we propose Expected Predictive Compression (EPC), which moves the key decision--what information to retain--to write time by using an LLM to anticipate likely future questions and preserve the minimal supporting evidence under the token budget, while leaving retrieval unchanged at question time. Across all 500 LongMemEval questions with three readers (GPT-5.2, Claude Sonnet 4, Gemini 2.5 Pro), EPC achieves the highest CSM scores among all systems (0.49 vs. 0.44 for Summary (LLM), the strongest baseline), reducing Delta_write to 0.04 while leaving Delta_retr comparable to other LLM-based systems. These results suggest that, on this benchmark and evaluation setup, improving what the write stage preserves is a key avenue for performance gains in the tested systems.

Jiangnan Yu, Kisson Songqi Lin, Jilong Wu

Question-Answering Benchmarks Bottlenecks Reasoning Gaps Oracles Diagnosis

May 23, 2026eess.SY

Asymmetric Adaptation-based Real-time Fault Diagnosis Under Transitional Operating Conditions

Data streams in real-world industrial scenarios often contain transitional operating conditions that are uncovered during offline training, leading to significant distribution shifts. To bridge the gap between static offline models and dynamic online data, a novel asymmetric adaptation-based fault diagnosis method is proposed in this paper. Specifically, in the offline stage, we employ domain generalization techniques to extract domain-invariant features from multiple stable conditions and construct robust normalized fault prototypes as reference anchors. Subsequently, during online inference, we design an online test-time adaptation method based on a periodic prototype re-projection mechanism to dynamically update prototype positions. Furthermore, we utilize the geometric distribution derived from anchors to guide the updates of classifiers and adopt an asymmetric learning rate strategy for the feature extractor and classifier. The proposed approach ensures rapid adaptation to new transitional conditions while preserving the discriminative power inherited from the offline domain generalization initialization. Experimental results demonstrate that this mechanism effectively leverages offline generalized knowledge to guide online inference, significantly improving robustness in non-stationary environments.

Hongshuo Zhao, Zeyi Liu, Xiao He

MCC5 Group Shanghai Co. LTD Shanghai, China

Fault Diagnosis Multimodal Domain Generalization Industrial Diagnosis Information Asymmetry

May 23, 2026cs.AI

ConceptM $^3$ oE: Concept-Guided Multimodal Mixture of Experts for Interpretable Computational Pathology

Healthcare models are transitioning from unimodal prediction toward multimodal reasoning over heterogeneous diagnostic inputs. In computational pathology, for complex tumor subtypes where morphology alone can be challenging to distinguish, pathology reports and molecular measurements may provide additional diagnostic evidence alongside whole-slide images, yet existing models often fail to clarify how diverse signals assemble into recognizable diagnostic concepts. We propose ConceptM

^3

oE (Concept Multimodal MoE), which embeds concept formation directly within interaction-aware mixture-of-experts (MoE) pathways. The architecture decomposes evidence into modality-specific, redundant, and synergistic experts, which are then projected into structured concept bottlenecks mapping latent features to a hierarchy of morphology and biomarker concepts. To prevent the information loss typical of interpretable bottlenecks, we utilize residual pathways within each expert to allow task-relevant signals to flow both through the concepts and directly to the final task prediction, so that high performance is maintained alongside interpretability. Across an institutional pediatric brain tumor cohort and a public glioma cohort, the framework delivers competitive performance to unconstrained models while producing reasoning traces validated by an independent neuropathologist. In data-limited regimes, ConceptM

^3

oE improves limited-data performance, increasing macro-F1 from 56.41% to 66.70% at small training sizes compared to non-concept-informed baselines, while also showing faster training convergence consistent with the regularizing effect of concept learning. This work offers a scalable path toward high-performance medical AI that is inherently verifiable and better aligned with the complex decision-making of clinical practice.

Xuan Wang, Zhongling Xu, Gopi Kannedhara +13

University of Texas at Austin, Austin, TX, USA · University of North Carolina at Chapel Hill, NC, USA · Dell Children’s Medical Center, Austin, TX, USA +2

Computational Pathology Multimodal Clinical Data Multiple Instance Learning Concept Bottleneck Models Diagnosis Experts

May 22, 2026cs.CY

Divergent Recommendations, Convergent Diagnoses: Cross-Provider Failure-Mode Convergence in AI Commercial Recommendation

A brand whose customers use both ChatGPT and Claude for product recommendations faces a strategic choice: a single optimization playbook, or one per provider? Across 215 commercially-framed prompts in four measurement batches, the two providers disagree on which brands they recommend roughly two-thirds of the time (cross-provider recommendation Jaccard 0.35, below the 0.50-0.61 same-prompt rerun baseline). The picks diverge. But when neither provider recommends a brand, we classify the failure into one of three modes -- discoverability (the brand never reaches the model), compellingness (it reaches the model but isn't mentioned), or positioning (it's mentioned but not recommended) -- and on 7,763 such joint failures, both providers diagnose the same failure mode 95.1% of the time (clustered 95% CI [94.3%, 95.7%]). Agreement rises monotonically with falling brand prominence, from 81% [78.2%, 84.0%] on category leaders to 99.6% [99.3%, 99.9%] on long-tail regional brands. The two providers reach their picks by measurably different generative routes -- Anthropic recommends from priors 43-52% of the time, OpenAI 8-29% -- but they converge on the failure diagnosis where it matters most for the long tail. Work that addresses the diagnosed failure mode lifts visibility on both providers; positioning - and content-level work for category leaders is more provider-specific.

Will Jack, Noah Lehman, Keller Maloney +1

Unusual

Brand-As-Memory Ai-Based Openai Diagnosis

May 22, 2026cs.CV

VisAnalog: A Diagnostic Suite for Visual Concept Transfer on Natural Images

A useful test of visual concept learning is not just whether a model can recognize a concept in a single image, but whether it can preserve and manipulate concept-level properties under transformation and transfer them to new scenes. We introduce VisAnalog, a controlled suite for this setting on natural images. Each example instantiates

A\!:\!B::C\!:\,?

: images

B

and a hidden target image

D

are produced by applying the same deterministic transformation sequence to source images

A

and

C

. Given

A

,

B

, and

C

, a model must answer a multiple-choice question about

D

. The benchmark contains 617 human-validated questions spanning one- to four-step transformations such as zoom, quadrant swap, rotation, flip, and hue rotation. Across strong proprietary and open-source VLMs, end-to-end accuracy is substantially lower than oracle accuracy when

D

is directly shown, and degrades sharply as transformation depth increases, while human performance remains near the ceiling. A program-conditioned evaluation further separates failures of relation inference from failures of transformation application, showing that inferring the visual relation from

A \rightarrow B

is the dominant bottleneck, with additional application errors emerging on harder multi-step cases. The dataset is publicly available at https://huggingface.co/datasets/zli99/VisAnalog.

Zhaonan Li, Kyle R. Chickering, Bangzheng Li +13

Arizona State University · Luma AI · UC Davis

Vision Datasets Vista Diagnosis

May 21, 2026cs.AI

Active Evidence-Seeking and Diagnostic Reasoning in Large Language Models for Clinical Decision Support

Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty. Building on prior interactive evaluation efforts, we introduce an OSCE-inspired standardized patient simulator and a controlled, reproducible benchmark for active diagnostic inquiry. Across 468 cases and 15 models in our protocol, we observe that multi-turn evidence seeking reduces diagnostic accuracy by 12.75% and lowers supporting-evidence quality by 24.36% relative to full-context evaluation; error analyses associate these drops with premature diagnostic closure and inefficient questioning. Together, these results suggest that static full-context benchmarks may overestimate performance in interactive evidence-seeking settings, motivating complementary interactive assessment for safer clinical decision support.

Chen Zhan, Xihe Qiu, Xiaoyu Tan +8

School of Electronic and Electrical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China. · Department, Tencent Youtu Lab, Shanghai, 200233, China. · Department of Oncology, Jinshan Hospital, Fudan University, Shanghai, 201508, China. +4

Clinical Decision Support Diagnosis

May 20, 2026cs.CV

Look-Closer-Then-Diagnose: Confidence-Aware Ultrasound VQA via Active Zooming

Vision-Language Models (VLMs) have significantly advanced medical visual question answering, yet their performance in ultrasound remains suboptimal. In clinical practice, sonographers explicitly focus on lesion regions to formulate reports, though diagnostic interpretations sometimes vary due to inherent subjectivity. However, existing VLMs are not explicitly structured to interactively zoom into lesions prior to diagnosis; moreover, they typically treat annotations as unbiased ground truths, failing to account for their inherent subjectivity and ambiguity. In this paper, we propose a framework specifically designed to consider the sonographer's cognitive workflow. We first introduce a structured Zoom-then-Diagnose paradigm, which replicates the interactive search process to enable lesion-focused reasoning. Furthermore, within the Group Relative Policy Optimization (GRPO) framework, we introduce an uncertainty-aware reward derived from stochastic group-wise rollouts to estimate prediction consistency as a proxy for model confidence. Together, these two components encourage the model to reinforce accurate predictions on clear cases while remaining cautious under ambiguity. Experiments across liver, breast, and thyroid datasets show that our framework improves lesion localization by 39.3%, demonstrating that our model has learned the ability to actively look closer and diagnose.

Yue Zhou, Erxuan Wu, Yikang Sun +5

Computer Aided Medical Procedures (CAMP), TU Munich, Germany · Munich Center for Machine Learning (MCML), Munich, Germany · Zhongshan Hospital, Fudan University, China +1

Ultrasound Diagnosis

May 20, 2026cs.LG

ShapeBench: A Scalable Benchmark and Diagnostic Suite for Standardized Evaluation in Aerodynamic Shape Optimization

Rapid progress in aerodynamic shape optimization (ASO) has outpaced currently-available standardized evaluation frameworks. Fair comparison requires a unified benchmark spanning diverse shape classes, objective formulations, and matched-budget state-of-the-art baselines. We introduce ShapeBench, an open-source ASO benchmark with a unified API spanning 103 tasks across eight shape categories and multiple optimization regimes. Each ShapeBench task includes a validated surrogate for fast search; when feasible, a high-fidelity Computational Fluid Dynamics (CFD) pipeline for final verification is available, enabling systematic fidelity-gap analysis. ShapeBench provides a reproducible protocol with well-configured baselines to compare fairly using a consistent budget metric, allowing for comparison among both classical and LLM-driven methods, including general-purpose optimizers and a new domain-specialized evolutionary LLM baseline, ShapeEvolve. Results on ShapeBench demonstrate substantial variance in optimizer rankings across shape categories and problem formulations, with mean pairwise Spearman

ρ= 0.013

, so single-task conclusions do not reliably generalize across problem classes. The benchmark is also far from saturation; classical methods are rarely applicable across all shape categories and tasks, further highlighting the need for more general-purpose approaches.

Shaghayegh Fazliani, Krissh Chawla, Jack Guo +3

Stanford University. · Spinoza Labs.

Aerodynamics Shape Optimization Computational Fluid Dynamic Diagnosis

May 20, 2026cs.LG

MedExpMem: Adapting Experience Memory for Differential Diagnosis

Experienced physicians develop diagnostic expertise through clinical practice, acquiring not only disease knowledge but also the ability to differentiate confusable conditions. Current medical vision-language models (VLMs) lack this capability -- their parameters encode static knowledge that does not evolve across diagnostic encounters. We propose MedExpMem, an experience memory framework enabling VLM-based diagnostic agents to accumulate differential diagnosis expertise. Unlike retrieval-augmented generation, which retrieves encyclopedic disease descriptions, MedExpMem memorizes discriminative experience derived from the agent's own diagnostic failures and organizes them as pairwise differential notes encoding key discriminators, actionable decision rules and reasoning error patterns. The framework adopts a two-phase construction process mirroring physician learning: initial practice exposes knowledge gaps, and reflective re-diagnosis refines understanding. When encountering new cases, the agent retrieves experience memory to guide differential reasoning. We evaluate MedExpMem on a radiology benchmark spanning 11 subspecialties. Results demonstrate consistent accuracy improvements, maximum 7.0%, across diverse models and scales. Analytical experiments validate experience quality and robustness, demonstrating MedExpMem as a competitive method addresses medical adaptation needs beyond the reach of parameteric learning.

Qianhan Feng, Zhongzhen Huang, Yakun Zhu +4

The Chinese University of Hong Kong · Shanghai Jiao Tong University · Shanghai Innovation Institue

Diagnosis Medical Vision-Language Models

May 18, 2026cs.CL

Prompting language influences diagnostic reasoning and accuracy of large language models

Large language models (LLMs) are increasingly explored for clinical decision support, yet most evaluations are conducted in English, leaving their reliability in other languages uncertain. Here we evaluate the impact of prompting language on diagnostic reasoning and final diagnosis accuracy by comparing English and French performance across five LLMs (o3, DeepSeek-R1, GPT-4-Turbo, Llama-3.1-405B-Instruct, and BioMistral-7B). A total of 180 clinical vignettes covering 16 medical specialties were assessed by two physicians using an 18-point scale evaluating both diagnosis accuracy and reasoning quality. Four of the five models performed better in English (mean difference 0.37-0.91, adjusted p < 0.05), with the gap spanning multiple aspects of reasoning, including differential diagnosis, logical structure, and internal validity. o3 was the only model showing no overall language effect. These findings demonstrate that prompting language remains a critical determinant of LLM clinical performance, with implications for equitable linguistico-cultural deployment worldwide.

Adrien Bazoge, Josselin Corvellec, Sofiane Djillali Sid-Ahmed +1

Data Clinic, Nantes University Hospital, France

Diagnosis Clinical Decision Support

May 18, 2026cs.CV

Beyond Morphology: Quantifying the Diagnostic Power of Color Features in Cancer Classification

In histopathology, human experts primarily rely on color as a means of enhancing contrast to interpret tissue morphology, whereas machine vision models process color as raw statistical information. This distinction raises a fundamental question: to what extent can pixel intensity alone, independent of structural and morphological cues, support cancer classification? To address this question, we systematically evaluated the standalone discriminative power of global color features while deliberately excluding all morphological information. Specifically, we extracted statistical color moments and discretized RGB and HSV color histograms, and assessed their performance across ten diverse experimental settings using classical machine learning classifiers. Our results demonstrate that color features alone can achieve strong performance in binary diagnostic tasks (e.g., benign versus malignant), with classification accuracies reaching up to 89%. This performance is likely attributable to global chromatic shifts associated with malignancy. Importantly, these simple color-based representations consistently outperformed random baselines by a substantial margin, indicating that raw color distributions encode a non-random and diagnostically relevant signal for cancer detection. Consequently, this study suggests that simple, computationally efficient color features can serve as an effective pre-screening tool. By identifying samples with strong chromatic indicators of malignancy, these lightweight models could function as a first-pass triage system, reducing the computational burden on complex deep learning architectures.

Farnaz Kheiri, Shahryar Rahnamayan, Masoud Makrehchi

Dept. of Electrical, Computer and Software Engineering Ontario Tech University Oshawa, Ontario, Canada · Dept. of Engineering Brock University St. Catharines, Ontario, Canada

Cancer Detection Tissue Diagnosis Morphology Deep Learning

May 18, 2026cs.CV

Rad-VLSM: A Cross-Modal Framework with Semantics-Assisted Prompting for Medical Segmentation and Diagnosis

Medical image segmentation is more clinically valuable when it supports diagnosis rather than merely producing lesion masks. However, diagnostically relevant lesion cues are often subtle and localized, while existing models may be distracted by background tissues, acoustic artifacts, and irrelevant visual correlations. To address this problem, we propose Rad-VLSM, a two-stage cross-modal framework for semantics-assisted lesion focusing, robust segmentation, and visually grounded diagnosis. In the first stage, a BLIP-2-based vision-language alignment module identifies lesion-related candidate regions under semantic guidance and converts them into box prompts. In the second stage, these prompts are fed into a SAM-based multitask network, where a multi-candidate region aggregation strategy improves prompt stability and guides lesion segmentation. The predicted masks are then used as spatial priors for diagnosis, and a visual-radiomics fusion head integrates lesion-aware visual features with selected radiomics descriptors. By using semantic information for localization rather than direct prediction, Rad-VLSM reduces text-to-diagnosis dependence and grounds diagnosis in lesion-level evidence. Experiments on a private clinical breast ultrasound dataset and public benchmarks show that Rad-VLSM achieves strong segmentation and diagnostic performance with favorable generalization.

Fengyi Zhang, Xujie Zeng, Mohan Liu +2

Diagnosis Visible Image Fusion Cross-Modal

May 17, 2026cs.SE

DiagEval: Trajectory-Conditioned Diagnosis for Reliable Software Evaluation with GUI Agents

Evaluating LLM-generated interactive software requires execution in addition to static analysis. The key difficulty is that correctness is a graph-level reachable property over latent UI state-transition graphs, whereas a GUI evaluator observes only a single execution trajectory. A failed rollout therefore rules out only one realized path, leaving failure attribution ambiguous between evaluator-side execution error and genuine software defect. We present DiagEval, a trajectory-conditioned diagnostic evaluation protocol for post-failure GUI-agent evaluation of interactive software. Rather than blindly retrying from scratch, DiagEval reuses the failed trajectory to choose targeted diagnostic probes and aggregates their outcomes into an internal attribution signal. The latent-graph view motivates the diagnostic problem; DiagEval does not reconstruct the graph or estimate calibrated posterior probabilities. We evaluate DiagEval on WebDevJudge-Unit and RealDevBench across multiple GUI-agent evaluators and LLM backbones. On false-negative cases, DiagEval recovers 45.6-62.1% of failures that were initially misattributed to software defects, outperforming retry-based baselines with 34.4-160.6% relative gains. On the full evaluation sets, this recovery improves accuracy from 69.9% to 78.3% on WebDevJudge-Unit and from 65.0% to 81.6% on RealDevBench. These results suggest that reliable GUI-agent evaluation requires not only stronger execution, but also active failure diagnosis to disambiguate evaluator-side errors from genuine software defects. Our code is available at https://github.com/scutGit/DiagEval.

Sirui Hong, Zhijie Liu, Tengfei Li +3

1DeepWisdom · 2Independent Researcher · 3The Hong Kong University of Science and Technology (Guangzhou)

Model Debugging Diagnosis

May 17, 2026cs.LG

Radial-Angular Geometry for Reliable Update Diagnosis in Noisy-Label Learning

Noisy-label methods often estimate sample reliability from forward-space signals such as loss, confidence, or entropy. These signals indicate whether a sample is difficult to predict, but they do not directly test whether its observed label induces a reliable parameter update. This gap matters because hard clean samples and mislabeled samples can have similar loss while inducing different updates. We recast reliability estimation as diagnosis of the observed-label update. The sample-wise empirical Fisher trace gives a backward-space measure of update energy: for the classifier layer, it factorizes into a prediction-residual term and a feature-sensitivity term, so it captures information beyond scalar loss. Trace, however, is still a radial magnitude signal and cannot decide whether a large update is useful or harmful. We therefore propose Relative Geometric Conflict (RGC), which compares the observed-label gradient with a reference gradient induced by an EMA teacher. The conflict term helps distinguish large but aligned hard-clean updates from large conflicting updates caused by corrupted labels. Across synthetic and real-world noisy-label benchmarks, RGC improves hard-clean preservation and accuracy under our evaluation protocol.

Ningkang Peng, Jingyang Mao, Xiaoqian Peng +2

Nanjing Normal University · Nanjing University of Chinese Medicine

Noisy Labels Diagnosis

May 17, 2026cs.AI

Reasoning Before Diagnosis: Physician-Inspired Structured Thinking for ECG Classification

Electrocardiogram (ECG) diagnosis in clinical practice relies on structured reasoning over multiple hierarchical aspects, including cardiac rhythm, conduction properties, waveform morphology, and overall diagnostic impression. However, most existing approaches predict labels directly from ECG signals without explicit clinical reasoning, resulting in opaque decisions that lack clinical alignment. To bridge this gap, we propose CardioThink, a physician-inspired multimodal large language model (MLLM) framework that explicitly models the diagnostic reasoning process through human-interpretable intermediate stages (rhythm, conduction, morphology, and impression) to derive final classification results. Furthermore, we introduce Structured Set Policy Optimization (SSPO) to jointly optimize adherence to this structured reasoning format and the accuracy of variable-size diagnostic sets, without requiring manually annotated reasoning traces. Extensive experiments on diverse ECG benchmarks demonstrate the significant superiority of our approach in diagnostic accuracy, while simultaneously providing interpretable clinical reasoning. Notably, reasoning quality evaluations confirm that SSPO substantially enhances the clinical validity of the generated rationales. These findings reveal that moving beyond direct label prediction toward structured reasoning offers a more clinically aligned direction for future ECG modeling.

Yang Wu, Xiaoyan Yuan, Hau-San Wong +1

1City University of Hong Kong · 2Beijing Institute of Technology · 3Shenzhen MSU-BIT University

Electrocardiogram Classification Cardiac Clinical Reasoning Training Diagnosis Multimodal Large Language Models

May 14, 2026cs.LG

Spectral Priors vs. Attention: Investigating the Utility of Attention Mechanisms in EEG-Based Diagnosis

Electroencephalograph (EEG) timeseries signals are characterized by significant noise and coarse spatial resolution, which complicates the classification of neurodegenerative diseases. Even SOTA deep learning architectures struggle to distinguish between healthy controls and diseased subjects, or between different disease types, due to high intergroup similarity. In this paper, we show that a spectrally selective approach to feature construction enhances class separability. By isolating signal strengths within the primary brainwave bands, we transform high dimensional raw data into high value spectral features. Our results demonstrate that in small datasets a) features derived from frequency and time frequency domain allow traditional machine learning models to match or exceed the performance of SOTA deep learning models, b) Attention mechanism is unable to distill the stable feature signatures that characterize healthy neural activity in both resting and task EEGs, and c) the limitations of attention based models in finding relevant spectral features appear to be robust in that providing frequency selective time domain input do not appreciably improve their performance. We validate our methodology across three open source resting EEG datasets and one task EEG dataset, providing robust empirical evidence for our claims.

Tawsik Jawad, Gowtham Atluri, Vikram Ravindra

University of Cincinnati, Cincinnati, OH, USA

Small-Sample Electroencephalogram Datasets Spectral Features Diagnosis Separability

May 14, 2026cs.AI

Holistic Evaluation and Failure Diagnosis of AI Agents

AI agents execute complex multi-step processes, but current evaluation falls short: outcome metrics report success or failure without explaining why, and process-level approaches struggle to connect failure types to their precise locations within long, structured traces. We present a holistic agent evaluation framework that pairs top-down agent-level diagnosis with bottom-up span-level evaluation, decomposing analysis into independent per-span assessments. This decomposition scales to traces of arbitrary length and produces span-level rationales for each verdict. On the TRAIL benchmark, our framework achieves state-of-the-art results across all metrics on both GAIA and SWE-Bench, with relative gains over the strongest prior baselines of up to 38% on category F1, up to 3.5x on localization accuracy, and up to 12.5x on joint localization-categorization accuracy. Per-category analysis shows our framework leading in more error categories than any other evaluator. Notably, the same frontier model achieves several times higher localization accuracy when used inside our framework than as a monolithic judge over the full trace, showing that evaluation methodology, not model capability, is the bottleneck.

Netta Madvil, Gilad Dym, Alon Mecilati +12

Deepchecks, Ramat Gan, Israel

Agentic Evaluations Diagnosis

May 14, 2026cs.CV

Diagnosing and Correcting Concept Omission in Multimodal Diffusion Transformers

Multimodal Diffusion Transformers (MM-DiTs) have achieved remarkable progress in text-to-image generation, yet they frequently suffer from concept omission, where specified objects or attributes fail to emerge in the generated image. By performing linear probing on text tokens, we demonstrate that text embeddings can distinguish a characteristic `omission signal' representing the absence of target concepts. Leveraging this insight, we propose Omission Signal Intervention (OSI), which amplifies the omission signal to actively catalyze the generation of missing concepts. Comprehensive experiments on FLUX.1-Dev and SD3.5-Medium demonstrate that OSI significantly alleviates concept omission even in extreme scenarios.

Kanghyun Baek, Jaihyun Lew, Chaehun Shin +2

Interdisciplinary Program in Artificial Intelligence, Seoul National University, Seoul, South Korea · Department of Electrical and Computer Engineering, Seoul National University, Seoul, South Korea · Department of Computer Science & Engineering, Korea University, Seoul, South Korea +1

Diffusion Transformers Omissions Transformer Architectures Diagnosis

May 13, 2026cs.CV

PRA-PoE: Robust Multimodal Alzheimer's Diagnosis with Arbitrary Missing Modalities

Missing modalities are prevalent in real-world Alzheimer's disease (AD) assessment and pose a significant challenge to multimodal learning, particularly when the distribution of observed modality subsets differs between training and deployment. Such missingness pattern mismatch induces a conditional representation shift across modality subsets. Existing approaches that rely on implicit imputation or modality synthesis often fail to explicitly model modality availability and uncertainty, leading to overconfident dependence on synthesized features, reduced robustness, and miscalibrated uncertainty estimates. To address these limitations, we propose PRA-PoE, an incomplete multimodal learning framework that is equipped with Prototype-anchored Representation Alignment (PRA) and an Uncertainty-aware Product of Experts (UA-PoE) fusion mechanism. First, PRA uses learnable global prototypes and availability-conditioned tokens to encode modality availability, distinguish observed from missing modalities, re-synthesize features for missing modalities, and adaptively refine observed representations to align latent spaces across modality subsets, with the goal of reducing representation shift under varying missingness patterns. Second, UA-PoE models each modality as a Gaussian expert and performs closed-form Product of Experts fusion, where experts with higher uncertainty are automatically down-weighted via lower precision, improving uncertainty reliability. We evaluate PRA-PoE under a clinically realistic protocol by training with naturally missing data and testing on all non-empty modality combinations. PRA-PoE consistently outperforms the state-of-the-art across datasets, achieving a 5.4% relative improvement in average accuracy on ADNI and a 10.9% relative gain in average F1 on OASIS-3 over the strongest baseline across all non-empty modality subsets.

Guangqian Yang, Ye Du, Wenlong Hou +2

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China · Department of Technology Management for Innovation, The University of Tokyo,2026 Japan · Department of Data Science and Artificial Intelligence, The Hong Kong Polytechnic University, Hong Kong SAR, China

Missing Modalities Multimodal Learning Alzheimer Modalities Imputation Diagnosis

May 11, 2026eess.IV

Brain Tumor Classification in MRI Images: A Computationally Efficient Convolutional Neural Network

Improving patient outcomes depends on the prompt and accurate diagnosis of brain tumors, but manual MRI scan analysis is still time-consuming and unreliable. Although deep learning has shown promise, many of the models that are now in use are computationally intensive and have difficulty handling the intrinsic complexity and variety of different types of brain tumors. In this work, we propose a lightweight yet high-performing Convolutional Neural Network (CNN) for multi-class brain tumor classification, employing MRI images to target gliomas, meningiomas, pituitary tumors, and healthy (no tumor) instances. The model was rigorously evaluated on two publicly accessible datasets from Figshare and Kaggle. Leveraging efficient feature extraction and optimized training strategies, our CNN achieved classification accuracies of 99.03% and 99.28%, along with ROC scores of 99.88% and 99.94% on Dataset 1 and Dataset 2, respectively-all while utilizing significantly fewer parameters than popular pre-trained architectures. In contrast to cutting-edge models like DenseNet201, MobileNetV2, VGG19, Xception, InceptionV3, and ResNet50, our approach consistently demonstrated superior performance with reduced computational overhead. These findings highlight the potential of the proposed model as a practical and reliable diagnostic aid in clinical environments.

Md Fahimul Kabir Chowdhury, Jannatul Ferdous

Department of Computer Science and Engineering, University of North Texas, USA · Department of Electrical and Electronic Engineering, International Islamic University Chittagong, Bangladesh

Brain Tumor Classification Convolutional Neural Networks Magnetic Resonance Imaging Tumor Diagnosis

May 11, 2026cs.LG

ASD-Bench: A Four-Axis Comprehensive Benchmark of AI Models for Autism Spectrum Disorder

Automated ASD screening tools remain limited by single-architecture evaluations, axis-restricted assessment, and near-exclusive focus on adult cohorts, obscuring age-specific diagnostic patterns critical for early intervention. We introduce ASD-Bench, a systematic tabular benchmark evaluating ML, deep learning, and foundation model configurations across three age cohorts (children 1-11 yr, adolescents 12-16 yr, adults 17-64 yr) on four axes: predictive performance, calibration, interpretability, and adversarial robustness. Applied to a curated v3 dataset of 4,068 AQ-10 records, our benchmark spans classical models (XGBoost, AdaBoost, Random Forest, Logistic Regression), neural networks (MLP), deep tabular transformers (TabNet, TabTransformer, FT-Transformer), and TabPFN v2. We introduce the Heuristic Aggregate Penalty (HAP): a cost-sensitive metric penalising false negatives more heavily and incorporating cross-validation variance for deployment stability. Adult classification yields high performance (10/17 models achieve perfect F1 and AUC), while adolescents present a harder task (F1 ceiling 0.837 vs. 0.915 for children). Feature hierarchies shift across cohorts: A9 (social motivation) dominates for children, A5 (pattern recognition) leads for adolescents, and adults exhibit a flatter importance profile consistent with developmental social masking. Accuracy and calibration are dissociated: AdaBoost achieves F1=1.000 on adults with ECE=0.302, confirming single-metric evaluation is insufficient for clinical AI. Cohort-specific deployment recommendations are provided. All findings should be interpreted as proof-of-concept evidence on questionnaire-derived labels rather than clinically validated diagnostic performance.

Shubhankit Singh, Hassan Shaikh, Kuldeep Raghuwanshi +1

Research Commons AI · IIT Bombay · IIT Delhi

Autism Spectrum Disorder Diagnostic Benchmark Artificial Intelligence Models Diagnosis Developmental Trajectories

May 11, 2026cs.CR

Acceptance Cards:A Four-Diagnostic Standard for Safe Fine-Tuning Defense Claims

Safe fine-tuning defenses are often endorsed on the basis of a held-out gap reduction, but the same reduction can come from sampling noise, subject artifacts, capability loss, or a mechanism that does not transfer. We introduce Acceptance Cards: an evaluation protocol, a documentation object, an executable audit package, and a claim-specific evidential standard for safe fine-tuning defense claims. The protocol checks statistical reliability, fresh semantic generalization, mechanism alignment, and cross-task transfer before treating a gap reduction as a full-card pass. Re-scored under this installed-gap protocol, SafeLoRA fails the full-card pass on Gemma-2-2B-it: under strict mechanism-class coding it fails all four diagnostics, and under a permissive shrinkage relabel it still fails three of four. This is a narrow installed-gap audit on one model family, not a global judgment of SafeLoRA's effectiveness. In a 46-cell audit, no cell satisfies the strict conjunction. The closest family is a near miss that passes reliability and mechanism checks where the required data are available, but fails the fresh-subject threshold, lacks a strict transfer pass, and carries a measurable deployment-accuracy cost.

Phongsakon Mark Konrad, Toygar Tanyel, Serkan Ayvaz

Centre for Industrial Software, University of Southern Denmark, Alsion 2, Sønderborg, 6400, Denmark · ProMake, Newark, DE, USA

Large Language Model Safety Model Fine-Tuning LLM Defense Mechanisms Evaluation Protocols Acceptance Decision Thresholds+2

May 11, 2026cs.LG

Efficient Neural Architectures for Real-Time ECG Interpretation on Limited Hardware

Electrocardiogram (ECG) interpretation is essential for diagnosing a wide range of cardiac abnormalities. While deep learning has shown strong potential for automating ECG classification, many existing models rely on large, computationally intensive architectures that hinder practical deployment. In this paper, we present an empirical study of convolutional neural network (CNN) architectures, exploring tradeoffs between diagnostic accuracy and computational efficiency. We benchmark two established baselines: AttiaNet, a compact model composed of sequential temporal and spatial blocks, and DeepResidualCNN, the winning architecture of the 2021 PhysioNet/Computing in Cardiology Challenge. Building on these, we propose three lightweight models: (i) ParallelCNN, which employs dual temporal and spatial branches for parallel pattern extraction; (ii) ParallelCNNew, a variant with symmetric weight initialization for balanced feature learning; and (iii) SimpleNet, a streamlined architecture that jointly processes temporal and spatial dimensions. Our experiments span three publicly available 12-lead ECG datasets from Germany, China, and the United States, covering binary, multiclass, and multilabel classification tasks across diverse patient populations. We further evaluate the impact of integrating low-cost demographic metadata (age and sex) to improve performance with minimal overhead. To ensure fair comparison, we introduce a unified Efficiency Score that integrates model size, inference speed, memory usage, and AUC performance. By balancing diagnostic performance and efficiency, our models offer a scalable and viable foundation for next-generation AI systems in cardiovascular care.

Ashery Mbilinyi, Callum O'Riley, Julia Handra +8

Department of Computer Science University of Victoria Victoria, Canada · Department of Electrical and Computer Engineering University of British Columbia Vancouver, Canada · Faculty of Medicine University of British Columbia Vancouver, Canada +4

Electrocardiogram Classification Adult-To-Pediatric Electrocardiogram Transfer Cardiac Efficientnet Encoder Deep Learning Architectures Convolutional Neural Networks+3

May 11, 2026cs.AI

The Metacognitive Probe: Five Behavioural Calibration Diagnostics for LLMs

The Metacognitive Probe is an exploratory five-task, 15-slot diagnostic that decomposes an LLM's confidence behaviour into five behaviourally-distinct dimensions: confidence calibration (T1-CC), epistemic vigilance (T2-EV), knowledge boundary (T3-KB), calibration range (T4-CR), and reasoning-chain validation (T5-RCV). It is evaluated on N=8 frontier models and N=69 humans. The instrument is motivated by Flavell (1979) and Nelson and Narens (1990) but operates on observable confidence-correctness alignment; it is not a validated cross-species metacognition scale, and the pre-specified human developmental hypothesis was falsified. Composite benchmarks (MMLU, BIG-Bench, HELM, GPQA) ask whether a model produces a correct response. They are silent on whether the model knows when its response is wrong. A model can score 80 on a composite calibration benchmark and still be wildly overconfident in narrow pockets the aggregate cannot surface. The Metacognitive Probe surfaces those pockets. Our headline is a 47-point within-model dissociation in Gemini 2.5 Flash: panel-best within-task calibration (T1-CC = 88; Spearman rho = +0.551, 95% CI [+0.14, +0.80], p = 0.005) and panel-worst cross-task difficulty prediction (T4-CR = 41; sigma_conf = 1.4 across twelve factoids).

Rafael C. T. Oliveira

Independent Researcher

Metacognition Confidence Calibration Diagnosis Developmental Trajectories

May 10, 2026cs.MA

SAGE: Scalable Agentic Grounded Evaluation for Crop Disease Diagnosis

Plant disease diagnosis is critical for food security, yet training disease-recognition models that generalize across crops, pathogens, and field conditions remains challenging because labeled disease images are far less abundant and standardized than data for other biotic stresses such as insects or weeds. Frontier vision-language models offer new opportunities through improved visual reasoning, but they still struggle with fine-grained disease identification due to the lack of structured, crop-specific symptom knowledge. To address this gap, we curate the largest plant disease image--symptom dataset to date, covering 335 crops, 1{,}251 disease classes, and approximately 839K images, designed to support training-free, agentic disease prediction. A scalable automated pipeline generates source-grounded symptom descriptions in which each claim is linked to a verbatim web quote; domain experts validate sampled crops and reconcile disease-name variants across sources. As a baseline, we introduce an autonomous visual reasoning agent that identifies anatomical context, narrows candidate diseases using symptom knowledge, sequentially compares reference images, and produces a fully explainable reasoning trace. Incorporating symptom knowledge improves accuracy by 16.2 percentage points on average at the full reference budget, with consistent gains across all four evaluation crops. Because the framework only requires crop-specific reference images and symptom knowledge, it can be extended to new crops without retraining, while the agentic baseline can directly benefit from future improvements in foundation model capabilities. Dataset and code are available at:https://sage-dataset.github.io/.

Muhammad Arbab Arshad, Tirtho Roy, Yanben Shen +7

Iowa State University, USA · New York University, USA

Leaf Disease Classification Disease Diagnosis Recent Vision-Language Models Readmission Prediction

May 10, 2026cs.AI

Medical Model Synthesis Architectures: A Case Study

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what treatment to try next. Despite increasing interest in developing AI systems that aid or even replace doctors in clinical settings, current systems struggle with calibrated reasoning under uncertainty, and are often deeply opaque about their reasoning. We propose a framework for AI systems that can make practically useful but formally transparent clinical predictions under uncertainty. Given a clinical situation, our framework (MedMSA) uses language models to retrieve relevant prior knowledge, but constructs a formal probabilistic model to support calibrated and verifiable inferences under uncertainty. We show how an initial proof-of-concept of this framework can be used for differential diagnosis, producing an uncertainty-weighted list of potential diagnoses that could explain a patients' symptoms, and discuss future applications and directions for applying this framework more generally for safe clinical collaborations.

Katherine M. Collins, Marlene Berke, Ilia Sucholutsky +6

MIT · University of Cambridge · Princeton University +8

Clinical Reasoning Training Clinical Prediction Diagnosis Artificial Intelligence Systems Uncertainty Probabilistic Model+1

May 10, 2026cs.LG

When Adaptation Fails: A Gradient-Based Diagnosis of Collapsed Gating in Vision-Language Prompt Learning

Adaptive prompting mechanisms have been proposed to enhance vision-language models by dynamically tailoring prompts to inputs. However, in frozen few-shot prompt learning with CLIP-style backbones, we systematically observe that adaptive gates and prompt-selection modules often collapse: they produce nearly constant outputs, contribute negligible gradient signals, and frequently fail to outperform fixed prompts. To further explore this issue, we present a systematic diagnostic study to uncover the underlying causes and conditions of adaptation failure. Through controlled experiments across datasets and multiple prompt learning architectures, we identify two recurring failure modes: gradient magnitude imbalance and gate degradation. Our findings invite a re-examination of indiscriminately adding architectural complexity in parameter-efficient learning and clarify when prompt-level adaptive gating is, and is not, effective in this regime.

Yunxuan Fang, Ziwei Zhang, Xinhe Wang

Beihang University · Beijing, China

Vision-Language Model Adaptation Multiple Prompt Learning Frameworks Few-Shot Learning Vision-Language Foundation Models Gating Diagnosis

May 9, 2026cs.LG

Diagnosing and Mitigating Domain Shift in Permission-Based Android Malware Detection

Machine learning-based Android malware detectors often fail in real-world deployment due to domain shift, where models trained on one data source perform poorly on applications from another. This paper presents a comprehensive study on the generalizability and interpretability of permission-based detectors under cross-domain conditions. Using two complementary datasets (PerMalDroid and NATICUSdroid) and five ensemble classifiers, we first establish an intra-domain baseline, where models achieve over 92% accuracy, and then quantify a severe asymmetric performance drop. While models trained on PerMalDroid generalize well to NATICUSdroid (86% accuracy), the reverse direction sees a drastic drop to 73% accuracy. Explainable AI analysis reveals bimodal feature distributions and shows that feature importance is highly unstable, with key permissions losing or gaining influence across domains. The predictive feature sets for different domains are fundamentally mismatched, as models rely on different, dataset-specific permissions. Most importantly, an ablation study demonstrates that for most models, training on a noisy feature set leads to poor generalization, confirming that domain-specific artifacts are a greater obstacle than missing features. To mitigate this, we validate a hybrid training strategy based on the intersection of common features and successfully recover cross-domain performance, achieving 88% accuracy on PerMalDroid and maintaining 97% on NATICUSdroid. These findings highlight the importance of explainable, cross-domain-robust malware detection systems and provide a practical pathway toward improving real-world deployment of permission-based Android malware detectors.

Md Rafid Islam

North South University, Department of Electrical and Computer Engineering, Bashundhara, Dhaka, 1229, Bangladesh

Mitigating Domain Shift Malware Device Access Control Diagnosis

May 9, 2026cs.CV

From pre-training to downstream performance: Does domain-specific pre-training make sense?

Deep learning techniques have revolutionised medical imaging, improving diagnostic accuracy and enabling both more accurate and earlier disease detection. However, the relationship between pre-training strategies and downstream performance in medical imaging models requires further exploration. Here, we systematically compare convolutional neural networks and transformers, examining various pre-training approaches, including supervised and self-supervised learning, as well as different initialisations and data modalities. Models are evaluated on natural images, chest X-rays, chest CT and retina OCT images, considering the effects of matching pre-training data with target modalities. Our findings indicate that only pre-training on data closely matching the target modality significantly improves downstream performance. While self-supervised learning can outperform supervised methods, its effectiveness varies with context. The study underscores the importance of pre-training strategies to enhance the reliability and effectiveness of deep learning models in medical imaging. By addressing these key factors, our research aims to contribute to the development of more accurate and dependable diagnostic tools, ultimately improving patient outcomes in clinical settings.

Felix Krones

Oxford Internet Institute, University of Oxford, Oxford, UK

Multimodal Pretraining Pretraining Deep Learning Modalities Diagnosis Downstream Reasoning

May 9, 2026cs.SE

Debugging the Debuggers: Failure-Anchored Structured Recovery for Software Engineering Agents

Software engineering agents are increasingly deployed in evaluable engineering environments, yet post-failure recovery remains costly, manual, and ad hoc. Existing systems expose traces or generate follow-up feedback, but they do not convert heterogeneous runtime evidence into grounded, bounded recovery guidance for a subsequent attempt. We present PROBE, a failure-anchored framework for structured recovery in software engineering agents. PROBE organizes failed-run telemetry into structured evidence, structured diagnosis, and bounded recovery guidance through a Telemetry Layer, a Diagnosis Layer, and a Guidance Gate. The Telemetry Layer preserves fine-grained runtime signals, the Diagnosis Layer fuses cross-signal evidence into grounded diagnoses, and the Guidance Gate produces diagnosis-derived guidance only when it is evidence-grounded, actionable, and within the scope of agent-side behavior. We evaluate PROBE across three settings: repository-level software repair, enterprise workflow recovery, and AIOps service mitigation. On 257 initially unresolved cases, PROBE achieves 65.37% Top-1 diagnosis accuracy and a 21.79% recovery rate, outperforming the strongest non-PROBE baseline by 43.58 and 12.45 percentage points. The results reveal a diagnosis-recovery gap: accurate diagnosis is necessary but insufficient unless translated into bounded guidance that a subsequent attempt can execute and verify. Beyond controlled evaluation, a Microsoft IcM prototype shows that PROBE can attach as a non-intrusive side channel to existing service-diagnosis workflows without changing the agent policy, toolset, or execution budget. These results suggest that telemetry-grounded, failure-anchored recovery can improve post-failure recoverability under realistic engineering constraints.

Chenyu Zhao, Shenglin Zhang, Yihang Lin +7

Nankai University Tianjin, China · Tsinghua University Beijing, China · Microsoft Redmond, USA

Model Debugging Diagnosis

May 9, 2026cs.AI

Reconciling Consistency-Based Diagnosis with Actual-Causality-Based Explanations

We establish, from the point of view of Explainable AI (XAI), connections between Consistency-Based Diagnosis (CBD), on one side, and Actual Causality and Causal Responsibility, on the other. CBD has received little attention from the XAI community. Connections between these two areas could have a fruitful impact on XAI and Explainable Data Management.

Leopoldo Bertossi

Carleton University, Canada · IMFD, Chile · Emeritus Professor. Adjunct Professor Western University, Canada.

Xai Explainable Artificial Intelligence Explainable AI Methods Diagnosis

May 9, 2026cs.CV

PromptDx: Differentiable Prompt Tuning for Multimodal In-Context Alzheimer's Diagnosis

Deep learning models in medical imaging typically operate as parametric memory, diagnosing patients by recalling fixed knowledge learned during training. This contrasts sharply with clinical practice, where physicians employ analogical reasoning to diagnose new cases by referencing similar records from past exemplars. While In-Context Learning (ICL) frameworks such as Tabular Prior-Fitted Networks (TabPFN) offer a promising diagnosis-by-reference paradigm, they are designed with tabular-specific inductive priors and rely on non-differentiable preprocessing pipelines, leading to manifold mismatch and gradient fracture when applied to heterogeneous multimodal data. To address these limitations, we propose PromptDx, a novel diagnosis-by-reference framework that leverages a pre-trained TabPFN as an ICL engine while enabling seamless integration with multimodal representations. Our core contribution is a Differentiable Prompt Tuning (DPT) mechanism that aligns a Masked Multimodal Modeling module with the pre-trained ICL engine. By training a lightweight adapter as a differentiable surrogate for the engine's non-differentiable preprocessors, we enable an end-to-end optimization of multimodal prompts within the ICL paradigm. We validate our method on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset using 3D MRI and tabular biomarkers. Experiments demonstrate that our approach outperforms traditional parametric baselines. Notably, our method achieves superior performance using only 1% context samples compared to 30% in standard ICL, demonstrating exceptional manifold condensation ability. We further validate the generalizability of our DPT framework across six tabular datasets with diverse scales. Overall, our method offers a more data-efficient and clinically aligned paradigm for Alzheimer's Disease diagnosis.

Lujia Zhong, Yihao Xia, Shuo Huang +2

Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California · Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California · Alfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California

Multimodal Clinical Data Alzheimer Medical Imaging Datasets Soft Prompt Tuning Diagnosis In-Context Learning+2

May 8, 2026cs.AI

Human-LLM Dialogue Improves Diagnostic Accuracy in Emergency Care

Clinical decision-making in emergency medicine demands rapid, accurate diagnoses under uncertainty. Despite benchmark progress, evidence for LLMs as interactive aids in live physician workflows remains sparse. MedSyn lets physicians iteratively query an LLM provided with the full clinical record while initially viewing only the chief complaint. Seven physicians (three seniors, four residents) completed baseline and AI-assisted sessions across 52 MIMIC-IV cases stratified by difficulty. Blinded evaluation showed residents' Hard-case correctness rose from 0.589 to 0.734; difficulty-standardised completely-correct rates confirmed a medium effect (Δ = 0.092; p = 0.071; d = 0.47). Automated metrics corroborated these gains: standardised any-match accuracy improved by 0.156 (p < 0.0001), and residents showed the largest F1 gain (Δ = 0.138; p < 0.0001). Dialogue analysis revealed expertise-dependent strategies (seniors asked targeted, hypothesis-driven questions; residents relied on broader queries) and cross-expertise concordance increased (Δ = 0.145; p < 0.0001). Interactive LLM support meaningfully enhances diagnostic reasoning.

Burcu Sayin, Ngoc Vo Hong, Ipek Baris Schlicht +8

Department of Information Engineering and Computer Science, University of Trento, Italy · Department of Medicine, Azienda Sanitaria Universitaria Integrata del Trentino (ASUIT), Trento, Italy · Universitat Politècnica de València, Spain +2

Clinical Reasoning Training Emergency Departments Diagnosis Real-World Clinical Workflows Hypothesis-Driven Model Expansion

May 8, 2026cs.LG

Diagnosing Spectral Ceilings in Equivariant Neural Force Fields

We introduce a spectral-injection diagnostic for measuring which angular frequencies a trained equivariant force-field backbone preserves: inject a controlled angular-frequency perturbation into a molecular force field, attach a lightweight Spectral Prediction Network (SPN) to the frozen backbone, and read off which frequencies are recoverable. On aspirin, a quadratic SPN attached to an L = 2 NequIP backbone recovers the boundary signal at l = 4 but collapses at l = 5: a 11.7x cliff at the predicted drL boundary, with p dropping from 0.913 to 0.078. The same boundary-vs-above contrast persists across n = 4 independently trained backbones (raw-gain delta contrast, hierarchical cluster bootstrap) and is corroborated by a denominator-free injected-residual metric (R2_inj(4) = 0.374 versus R2_inj(5) = 0.006). A finite-degree span theorem calibrates the diagnostic: for a single marked direction, degree-d polynomials of degree-L spherical-harmonic features span exactly H less than or equal to dL with multiplicity-one saturation at the boundary (scoped to single-direction degree-bounded probes, not a function-class upper bound on multi-atom MPNNs). A synthetic C5 calibration plus capacity, activation, and cross-architecture controls rule out parameter count alone as the explanation.

Hyunmog Kim

Independent Researcher.

Spectral Neural Fields Frequency Diagnosis

May 8, 2026cs.CL

MedAction: Towards Active Multi-turn Clinical Diagnostic LLMs

Most existing LLM diagnoses are evaluated on static, single-turn settings where complete patient information is provided upfront, an oversimplification of real clinical practice. We study active diagnosis: the real-life clinical process of starting from initial observation, ordering tests, interpreting results, and updating a differential diagnosis across multiple turns. Through systematic analysis, we identify three recurring failure modes in current LLMs: ungrounded test ordering, unreliable diagnostic update, and degraded multi-turn coherence. Together, these failures reveal a core deficit: existing medical training data teaches models to reason from complete information but not to act under evolving, partial evidence. To address this gap, we introduce MedAction, a tree-structured distillation pipeline that synthesizes diverse and high-quality multi-turn diagnostic trajectories via LLM-environment interaction. We propose two knowledge-graph-grounded metrics to filter trajectory quality: Disease Trajectory Consistency (DTC), which tracks whether the model's hypothesis converges toward the correct diagnosis, and Reasoning-Action Consistency (RAC), which verifies that belief updates are driven by gathered evidence. Using this pipeline, we construct MedAction-32K, a dataset of 32,681 trajectories from 2,896 PMC cases. Fine-tuning an 8B model on MedAction-32K achieves state-of-the-art performance among open-source models on both MedR-Bench and our curated MedAction-300-Hard benchmark, pushing the edge for open-source medical LLMs.

Hsin-Ling Hsu, Zizheng Wang, Donghua Zhang +9

1National Chengchi University · 2Georgetown University · University of Michigan +3

Diagnosis Patient Trajectories

May 8, 2026cs.CL

MedExAgent: Training LLM Agents to Ask, Examine, and Diagnose in Noisy Clinical Environments

Real-world clinical diagnosis is a complex process in which the doctor is required to obtain information from both interaction with the patient and conducting medical exams. Additionally, the doctor needs to adapt to different patient personas, as well as noisy and incomplete information that can happen at any time during the process. However, existing benchmarks for medical LLMs and methods for automatic diagnosis largely simplify this process by reducing it to single-turn question answering, noise-free conversations, or sequential exam making, etc., ignoring the interactive and uncertain nature of clinical diagnosis. In this paper, we aim to address this gap by formalizing clinical diagnosis as a Partially Observable Markov Decision Process (POMDP) with three action types: questioning the patient, ordering medical exams as tool calls, and issuing a diagnosis. We also introduce a systematic noise model comprising seven patient noise types and three exam noise types. Using our proposed environment, we train an effective diagnosis agent, \textbf{MedExAgent}, through a two-stage pipeline that first performs supervised finetuning on synthetic conversations structured after the Calgary-Cambridge model for clinical interviews, and then applies DAPO to optimize a composite reward capturing diagnostic accuracy, tool call quality, and exam cost including financial cost and patient discomfort. Through extensive experiments and ablation studies, we demonstrate that MedExAgent achieves diagnostic performance comparable to larger models while maintaining cost-efficient examination strategies.

Yicheng Gao, Xiaolin Zhou, Yahan Li +2

University of Southern California · Arizona State University

Diagnosis Large Language Model Agents Partially Observable Markov Decision Process

May 7, 2026cs.LG

Streaming Adversarial Robustness in Fuzzy ARTMAP: Mechanism-Aligned Evaluation, Progressive Training, and Interpretable Diagnostics

Adversarial robustness has been studied extensively for offline deep networks, but less is known about strict single-pass streaming neural learners. This paper studies adversarial robustness in Fuzzy ARTMAP, an Adaptive Resonance Theory architecture based on category competition, complement coding, match tracking, and replay-free prototype updates. We introduce WB-Softmax, a differentiable white-box attack surrogate aligned with ARTMAP's category-competition and map-field prediction mechanism, and formalize a streaming evaluation principle requiring robustness to be assessed on the final deployed model. Across four image benchmarks, WB-Softmax achieves 89-100% attack success on vanilla Fuzzy ARTMAP models. We show that defense rankings can reverse across protocols: offline adversarial training may appear strong under transfer attacks yet collapse under adaptive white-box evaluation, whereas progressive two-stage selective training provides the strongest overall replay-free robustness. We further show that ART's explicit category geometry enables interpretable diagnosis of separation collapse and match-score inversion. These results provide a mechanism-aligned, protocol-aware framework for adversarial robustness in streaming prototype-based learners.

Shane Cairns, Leonardo Enzo Brito da Silva, Sasha Petrenko +2

Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, MO, USA · Instituto Metrópole Digital, Universidade Federal do Rio Grande do Norte, Natal, RN 59078-900, Brazil · Kummer Institute Center for Artificial Intelligence and Autonomous Systems (KICAIAS), Missouri University of Science and Technology, Rolla, MO, USA

Adversarial Training Gumbel-Softmax Relaxation Diagnosis

May 7, 2026cs.AI

A Versatile AI Agent for Rare Disease Diagnosis and Risk Gene Prioritization

Accurate and timely diagnosis is essential for effective treatment, particularly in the context of rare diseases. However, current diagnostic workflows often lead to prolonged assessment times and low accuracy. To address these limitations, we introduce Hygieia, a multi-modal AI agent system designed to support precision disease diagnosis by integrating diverse data sources, including phenotypic features, genetic profiles, and clinical records. Hygieia features a router-based and knowledge-enhanced framework that mitigates hallucination and tailors diagnostic strategies to different disease categories. Notably, it prioritizes risk-related genomic factors for rare diseases and provides confidence scores to assist clinical decision-making. We conducted a comprehensive evaluation demonstrating that Hygieia achieves state-of-the-art performance across multiple diagnostic benchmarks. In collaboration with clinical experts from Yale School of Medicine and Duke-NUS Medical School, we further validated its practical utility by showing (1) Hygieia's superior diagnostic performance compared to physicians with an improvement from 12%-60% and (2) its effectiveness in assisting clinicians with medical records for handling real-world cases. Our findings indicate that Hygieia not only enhances diagnostic accuracy and interpretability but also significantly reduces clinician workload, highlighting its potential as a valuable tool in clinical decision support systems.

Tianyu Liu, Wangjie Zheng, Rui Yang +12

Interdepartmental Program in Computational Biology and Bioinformatics, Yale University · Department of Biostatistics, Yale University · Broad Institute of MIT and Harvard +13

Rare Disease Diagnosis Clinical Decision Support Multimodal Agents Interpretability

May 7, 2026stat.AP

Correcting heterogeneous diagnostic bias when developing clinical prediction models using causal hidden Markov models

In routine care, individuals identified a priori as high-risk are usually tested for conditions more frequently. Protected attributes, such as sex or ethnicity may also determine testing frequency. Such heterogeneous detection rates across a population induce label error. This causes systematic model error for specific groups and biases performance metrics during validation. This paper proposes a method to correct for such bias in prediction models due to differential diagnostic delay. We use a causal inference framework to define our target estimand: an individual's diagnosis probability in a counterfactual scenario where their diagnosis rate matches that of a reference group. We model the longitudinal process as a hidden Markov model, in which confirmatory test results are emissions from a latent progressive disease stage. We validate our approach in simulated data and apply it to a case study of chronic kidney disease prediction using electronic health records. In simulations, our method reduces prediction bias and improves calibration-in-the-large, correcting the Observed:Expected ratio in the underdiagnosed group from 1.34 (standard deviation: 0.09) in a model developed without any correction for underdiagnosis bias to 1.02 (0.09). Violations of assumptions in the simulation affected the estimation of model parameters, but the proposed approach nonetheless remained better calibrated than the standard model. In the clinical case study, we identify diabetes as the main driver of observability, with an odds ratio of 10.36 (95% confidence interval, 9.80 - 11.02) in 6-month urine albumin-creatinine ratio testing rate. Using our approach to predict the counterfactual diagnostic rate in patients without diabetes, we improved the Observed:Expected ratio of a developed clinical prediction model from 1.55 (1.51 - 1.59) to 1.01 (0.98 - 1.04).

Jose Benitez-Aurioles, Ricardo Silva, Brian McMillan +1

Division of Informatics, Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom · Department of Statistical Science, UCL, London, United Kingdom · Division of Population Health, Health Services Research & Primary Care, University of Manchester, Manchester, United Kingdom

Clinical Prediction Chronic Kidney Disease Diagnosis Causal Inferences Causal Markov