Foundation Model

Cognitive neuroscience is fragmented into specialized models, each tailored to specific experimental paradigms, hence preventing a unified model of cognition in the human brain. Here, we introduce TRIBE v2, a tri-modal (video, audio and language) foundation model capable of predicting human brain activity in a variety of naturalistic and experimental conditions. Leveraging a unified dataset of over 1,000 hours of fMRI across 720 subjects, we demonstrate that our model accurately predicts high-resolution brain responses for novel stimuli, tasks and subjects, superseding traditional linear encoding models, delivering several-fold improvements in accuracy. Critically, TRIBE v2 enables in silico experimentation: tested on seminal visual and neuro-linguistic paradigms, it recovers a variety of results established by decades of empirical research. Finally, by extracting interpretable latent features, TRIBE v2 reveals the fine-grained topography of multisensory integration. These results establish artificial intelligence as a unifying framework for exploring the functional organization of the human brain.

Audio-Visual Intelligence (AVI) has emerged as a central frontier in artificial intelligence, bridging auditory and visual modalities to enable machines that can perceive, generate, and interact in the multimodal real world. In the era of large foundation models, joint modeling of audio and vision has become increasingly crucial, i.e., not only for understanding but also for controllable generation and reasoning across dynamic, temporally grounded signals. Recent advances, such as Meta MovieGen and Google Veo-3, highlight the growing industrial and academic focus on unified audio-vision architectures that learn from massive multimodal data. However, despite rapid progress, the literature remains fragmented, spanning diverse tasks, inconsistent taxonomies, and heterogeneous evaluation practices that impede systematic comparison and knowledge integration. This survey provides the first comprehensive review of AVI through the lens of large foundation models. We establish a unified taxonomy covering the broad landscape of AVI tasks, ranging from understanding (e.g., speech recognition, sound localization) to generation (e.g., audio-driven video synthesis, video-to-audio) and interaction (e.g., dialogue, embodied, or agentic interfaces). We synthesize methodological foundations, including modality tokenization, cross-modal fusion, autoregressive and diffusion-based generation, large-scale pretraining, instruction alignment, and preference optimization. Furthermore, we curate representative datasets, benchmarks, and evaluation metrics, offering a structured comparison across task families and identifying open challenges in synchronization, spatial reasoning, controllability, and safety. By consolidating this rapidly expanding field into a coherent framework, this survey aims to serve as a foundational reference for future research on large-scale AVI.

Evidence derived from large-scale real-world data (RWD) is increasingly informing regulatory evaluation and healthcare decision-making. Administrative claims provide population-scale, longitudinal records of healthcare utilization, expenditure, and detailed coding of diagnoses, procedures, and medications, yet their potential as a substrate for healthcare foundation models remains largely unexplored. Here we present ReClaim, a generative transformer trained from scratch on 43.8 billion medical events from more than 200 million enrollees in the MarketScan claims data spanning 2008-2022. ReClaim models longitudinal trajectories across diagnoses, procedures, medications, and expenditure, and was scaled to 140 million, 700 million, and 1.7 billion parameters. Across over 1,000 disease-onset prediction tasks, ReClaim achieved a mean AUC of 75.6%, substantially outperforming disease-specific LightGBM (66.3%) and the transformer-based Delphi model (69.4%), with the largest gains for rare diseases. These advantages held across retrospective and prospective evaluations and in external validation on two independent datasets. Performance improved monotonically with scale, and post-training added 13.8 percentage points over pre-training alone. Beyond disease prediction, ReClaim captured financial outcomes and improved real-world evidence (RWE) analyses: for healthcare expenditure forecasting it increased explained variance from 0.28 to 0.37 relative to LightGBM, and in a target trial emulation it reduced systematic bias by 72% on average relative to Delphi. Together, these results establish administrative claims as a scalable substrate for healthcare foundation models and show that learned representations generalize across time periods and data sources, supporting disease surveillance, expenditure forecasting, and RWE generation.

The advent of foundation models has heralded a new era in medical artificial intelligence (AI), enabling the extraction of generalizable representations from large-scale unlabeled datasets. However, current ophthalmic AI paradigms are predominantly constrained to single-modality inference, thereby creating a dissonance with clinical practice where diagnosis relies on the synthesis of complementary imaging modalities. Furthermore, the deployment of high-performance AI in resource-limited settings is frequently impeded by the unavailability of advanced three-dimensional imaging hardware. Here, we present the Ophthalmic multimodal Masked Autoencoder (OphMAE), a multi-imaging foundation model engineered to synergize the volumetric depth of 3D Optical Coherence Tomography (OCT) with the planar context of 2D en face OCT. By implementing a novel cross-modal fusion architecture and a unique adaptive inference mechanism, OphMAE was pre-trained on a massive dataset with of 183,875 paired OCT images derived from 32,765 patients. In a rigorous benchmark encompassing 17 diverse diagnostic tasks with 48,340 paired OCT images from 8,191 patients, the model demonstrated state-of-the-art performance, achieving an Area Under the Curve (AUC) of 96.9% for Age-related Macular Degeneration (AMD) and 97.2% for Diabetic Macular Edema (DME), consistently surpassing existing single-modal and multimodal foundation models. Crucially, OphMAE exhibits robust engineering adaptability: it maintains high diagnostic accuracy, such as 93.7% AUC for AMD, even when restricted to single-modality 2D inputs, and demonstrates exceptional data efficiency by retaining 95.7% AUC with as few as 500 labeled samples. This work establishes a scalable and adaptable framework for ophthalmic AI, ensuring robust performance across different tasks.

Foundation models, particularly large language models, are increasingly integrated into agent architectures for industrial tasks such as decision support, process monitoring, and engineering automation. Yet evidence on their purposes, capabilities, and limitations remains fragmented across domains. This work examines how mature foundation-model-based agent systems are in industrial contexts, how their functional profile differs from conventional agent systems, and which limitations persist. A systematic literature survey following the PRISMA 2020 guideline is presented, screening 2,341 publications and synthesising a corpus of 88 publications through a structured coding scheme. The results show that reported systems are predominantly at prototype and early validation stages (75.0% at TRL 4-6), with deployment-oriented evidence remaining rare (9.1%). Operational goals are most frequently positioned in user assistance, monitoring, and process optimisation, while conventional production-control purposes such as planning and scheduling are less prominent. Compared with an established baseline for industrial agent systems, the capability profile reveals substantial gains in human interaction (+37%) and dealing with uncertainty (+35%), but a pronounced deficit in negotiation (-39%). The most widely reported limitations concern lack of generalization, hallucination and output instability, data scarcity, and inference latency. A working definition of foundation-model-based industrial agents is also proposed, bridging conventional agent theory, automation-engineering standards, and the foundation-model paradigm.

Vision Foundation Models (VFMs) pretrained on large-scale RGB data have demonstrated remarkable representation quality, yet their applicability to multispectral imaging spanning Near-Infrared (NIR), Short-Wave Infrared (SWIR), and Long-Wave Infrared (LWIR) remains largely unexplored. These spectral modalities offer complementary sensing capabilities critical for robust perception in adverse conditions, but present a fundamental domain gap relative to RGB-centric pretrained models. We present SpectraDINO, a multispectral VFM that bridges this spectral gap by extending DINOv2 ViT backbones to beyond-visible modalities through lightweight, per-modality bottleneck adapters, while preserving the rich representations of the frozen RGB backbone. We introduce a multi-stage teacher-student training protocol in which a frozen DINOv2 teacher guides a spectral student via cosine distillation, symmetric contrastive loss, patch-level alignment, and a novel neighborhood-structure-preservation loss. This staged curriculum enables strong cross-modal alignment without catastrophic forgetting of RGB priors. We evaluate SpectraDINO on multispectral object detection and semantic segmentation across challenging NIR, SWIR, and LWIR benchmarks using widely adopted fusion strategies. SpectraDINO achieves state-of-the-art performance across most benchmarks, validating its effectiveness as a general-purpose backbone for spectral generalization. The code and weights for model variants are available at https://github.com/Yonsei-STL/SpectraDINO.

Personalized federated learning (PFL) with foundation models has emerged as a promising paradigm enabling clients to adapt to heterogeneous data distributions. However, real-world scenarios often face the co-occurrence of non-IID data and long-tailed class distributions, presenting unique challenges that remain underexplored in PFL. In this paper, we investigate this long-tailed personalized federated learning and observe that current methods suffer from two limitations: (i) fine-tuning degrades performance below zero-shot baselines due to the erosion of inherent class balance in foundation models; (ii) conventional personalization techniques further transfer this bias to local models through parameter or feature-level fusion. To address these challenges, we propose Federated Learning via Gradient Purification and Residual Learning (FedPuReL), which preserves balanced knowledge in the global model while enabling unbiased personalization. Specifically, we purify local gradients using zero-shot predictions to maintain a class-balanced global model, and model personalization as residual correction atop the frozen global model. Extensive experiments demonstrate that FedPuReL consistently outperforms state-of-the-art methods, achieving superior performance on both global and personalized models across diverse long-tailed scenarios. The code is available at https://github.com/shihaohou/FedPuReL.

Wireless foundation models (WFMs) have emerged as a promising paradigm for unified channel state information (CSI) acquisition across diverse tasks in sixth-generation (6G) networks. Although WFMs significantly outperform task-specific small models, their zero-shot cross-scenario generalization still remains limited for real-world applications. Existing positional embeddings, the sole interface through which self-attention perceives the temporal-frequency-antenna 3D physical coordinates of CSI, fail to capture the highly dynamic and axis-dependent coherence inherent in wireless channels. This paper proposes Adaptive 3D-RoPE, a channel-driven 3D rotary positional embedding framework for WFMs to dynamically align the 3D positional embeddings with the instantaneous coherence state of heterogeneous CSI. The design proceeds in three stages: first, an axis-wise learnable rotary prior independently preserves the temporal, frequency, and antenna coordinate structures; second, a feature-guided rotary modulation module maps the feature-wise standard deviation of visible CSI tokens to compact, sample-adaptive scales; third, identical coordinate offsets induce dynamically adjusted query-key interactions tailored to the instantaneous channel state. Extensive experiments on both simulated and measured datasets validate the effectiveness of Adaptive 3D-RoPE across three complementary dimensions. It reduces NMSE by 10.14, 6.25, and 4.61 dB relative to baselines under antenna, temporal, and frequency scaling, respectively. It transfers effectively to real-world measured CSI and remains robust under imperfect CSI. Finally, it transfers to the independently designed LWM backbone and beam-prediction task, improving zero-shot Top-1 accuracy by 8.03 percentage points.

In this work, we introduce CellxPert, a scalable multimodal foundation model that unifies single-cell and spatial multi-omics within a common representation space. CellxPert jointly encodes transcriptomic (scRNA-seq), chromatin-accessibility (ATAC-seq), and surface-proteomic (CITE-seq) measurements, while directly incorporating MERFISH and imaging mass-cytometry data as 2D or 3D spatial-visual layers. CellxPert facilitates four key downstream tasks out of the box: (i) cell-type annotation across a broad ontology of 154 largely overlapping identities -- the largest label space addressed to date and a stringent test of fine-grained discrimination, (ii) efficient fine-tuning using Low Rank Adaptation (LoRA), (iii) genome-wide transcriptomic response prediction to in-silico perturbations (ISP), and (iv) seamless multi-omic integration across various assays and platforms. Unlike current single-cell foundation models, which approximate gene perturbations by deleting or reordering tokenized gene expression ranks, CellxPert employs a Metropolis-Hastings sampler whose proposal kernel uses the model's masked conditional distributions to transition to new transcriptomic states conditioned on the perturbed genes. This Markov-chain procedure mitigates out-of-distribution artifacts introduced by abrupt token manipulation and produces trajectories that are biologically interpretable. Evaluations on PBMC68K, Replogle Perturb-seq, Systema, and BMMC benchmarks show that CellxPert surpasses classical and state-of-the-art baselines in cell-type annotation, perturbation response prediction, and multi-omic integration.

Foundation models are deep neural networks (such as GPT-5, Gemini3, and Opus4) trained on large datasets that can perform diverse downstream tasks -- text and code generation, question answering, summarization, image classification, and so on. The philosophy of foundation models is to put effort into a single, large (${\sim}10^{12}$-parameter) general-purpose model that can be adapted to many downstream tasks with no or minimal additional training. We argue that the rise of foundation models presents an opportunity for hardware engineers: in contrast to when different models were used for different tasks, it now makes sense to build special-purpose, fixed hardware implementations of neural networks, manufactured and released at the roughly 1-year cadence of major new foundation-model versions. Beyond conventional digital-electronic inference hardware with read-only weight memory, we advocate a more radical re-thinking: hardware in which the neural network is realized directly at the level of the physical design and operates via the hardware's natural physical dynamics -- \textit{Physical Foundation Models} (PFMs). PFMs could enable orders-of-magnitude advantages in energy efficiency, speed, and parameter density. For ${\sim}10^{12}$-parameter models, this would both reduce the high energy burden of AI in datacenters and enable AI in edge devices that today are power-constrained to far smaller models. PFMs could also enable inference hardware for models much larger than current ones: $10^{15}$- or even $10^{18}$-parameter PFMs seem plausible by some measures. We present back-of-the-envelope calculations illustrating PFM scaling using an optical example -- a 3D nanostructured glass medium -- and discuss prospects in nanoelectronics and other physical platforms. We conclude with the major research challenges that must be resolved for trillion-parameter PFMs and beyond to become reality.

Policy optimization in high-dimensional continuous control for robotics remains a challenging problem. Predominant methods are inherently local and often require extensive tuning and carefully chosen initial guesses for good performance, whereas more global and less initialization-sensitive search methods typically incur high rollout costs. We propose TFM-S3, a tabular hybrid local-global method for improving global exploration in robot policy learning with limited rollout cost. We interleave high-frequency local updates with intermittent rounds of global search. In each search round, we construct a dynamically updated low-dimensional policy subspace via SVD and perform iterative surrogate-guided refinement within this space. A pretrained tabular foundation model predicts candidate returns from a small context set, enabling large-scale screening with limited rollout cost. Experiments on continuous control benchmarks show that TFM-S3 consistently accelerates early-stage convergence and improves final performance compared to TD3 and population-based baselines under an identical rollout budget. These results demonstrate that foundation models are a powerful new tool for creating sample-efficient policy learning methods for continuous control in robotics.

Federated Learning (FL) enables collaborative model training across distributed clients without sharing raw data, yet its performance deteriorates under statistical heterogeneity. Clustered Federated Learning addresses this challenge by grouping similar clients and training separate models per cluster. However, existing clustering strategies often rely on raw data statistics, model parameters, or heuristic similarity measures that fail to capture class-level semantic structure across heterogeneous domains and frequently require iterative coordination. We propose FMCL, a one-shot, class-aware client clustering framework that leverages foundation model representations to construct semantic client signatures. Using a frozen foundation model, FMCL computes class-level embedding prototypes for each client and measures similarity via cosine distance between their class-aware representations. Clustering is performed once prior to training, introducing no additional communication during federated optimization and remaining agnostic to the downstream model architecture. Extensive experiments across heterogeneous benchmarks demonstrate that FMCL improves federated performance and yields more stable clustering behavior compared to existing clustering-based methods under non-identically distributed data partitioning.

Training stable biological foundation models requires rethinking attention mechanisms: we find that using sigmoid attention as a drop in replacement for softmax attention a) produces better learned representations: on six diverse single-cell datasets, sigmoid achieves 25% higher cell-type separation, better cell-type cohesion metrics, and lower validation loss, b) faster training, models with sigmoid attention train up to 10% faster than their softmax counterparts, and c) more stable training by eliminating inherent sources of instability in softmax attention. We establish that sigmoid attention has globally bounded derivatives ($\leq 0.25$) as opposed to softmax, and a diagonal Jacobian structure in contrast with softmax's dense coupling, which together help alleviate training instabilities. In stress tests on 160M-parameter bidirectional attention models trained without gradient clipping on 8K-token sequences, softmax diverges catastrophically, with gradients exploding by four orders of magnitude, while sigmoid remains stable. Finally, we implement and open-source TritonSigmoid, an efficient GPU kernel that achieves 515 TFLOPS on H100 GPUs, outperforming both FlashAttention-2 and FlashSigmoid, with native padding support, which is essential for biological sequences. Our results establish sigmoid attention as both theoretically grounded and empirically superior for biological foundation models. Code is available at https://github.com/MSDLLCpapers/triton-sigmoid

We present GLM-5V-Turbo, a step toward native foundation models for multimodal agents. As foundation models are increasingly deployed in real environments, agentic capability depends not only on language reasoning, but also on the ability to perceive, interpret, and act over heterogeneous contexts such as images, videos, webpages, documents, GUIs. GLM-5V-Turbo is built around this objective: multimodal perception is integrated as a core component of reasoning, planning, tool use, and execution, rather than as an auxiliary interface to a language model. This report summarizes the main improvements behind GLM-5V-Turbo across model design, multimodal training, reinforcement learning, toolchain expansion, and integration with agent frameworks. These developments lead to strong performance in multimodal coding, visual tool use, and framework-based agentic tasks, while preserving competitive text-only coding capability. More importantly, our development process offers practical insights for building multimodal agents, highlighting the central role of multimodal perception, hierarchical optimization, and reliable end-to-end verification.

Hyperspectral imaging (HSI) semantic segmentation typically relies on in-domain training, but limited data availability often restricts model performance in real-world applications. Current approaches to leverage foundation models in proximal sensing use cross-modality techniques, bridging RGB and HSI to exploit vision foundation models. However, these methods either discard spectral information or introduce architectural complexity. We propose cross-domain transfer as an alternative, reusing HSI foundation models - originally trained in remote sensing - for proximal sensing applications. By eliminating the need to bridge modality gaps, our approach preserves spectral information while maintaining a simple architecture. Using the HS3-Bench benchmark, we systematically evaluate and compare conventional in-domain, in-modality training, cross-modality transfer and cross-domain transfer strategies. Our results demonstrate that cross-domain transfer achieves large performance improvements over in-domain, in-modality training, reduces the performance gap to cross-modality approaches and maintains strong performance in limited data settings. Thus, this work advances more effective HSI semantic segmentation in diverse applications.

Foundation models are reshaping computational histopathology, yet their value for whole-slide image retrieval relative to strong patch-based and supervised aggregation baselines remains unclear. We benchmarked ten pipelines on 9,387 diagnostic slides spanning 17 organs and 60 diagnoses from The Cancer Genome Atlas (TCGA) using patient-level leave-one-patient-out evaluation. Methods included four pre-trained slide foundation models, a supervised attention-based multiple instance learning (ABMIL) aggregator on patch embeddings, and patch-level retrieval across five sampling densities. Performance varied more across organs and diagnoses than across architectures. Although the slide foundation model TITAN achieved the strongest overall results, its advantage was modest; ABMIL and patch-based methods reached comparable Top-1 and Top-3 accuracy, with no model consistently dominant. Morphologically distinctive entities approached ceiling performance, while rare, heterogeneous, and closely related subtypes remained challenging. Misclassifications aligned with organs exhibiting known inter-observer variability, suggesting an intrinsic ceiling for morphology-only retrieval. Performance was driven primarily by patch-level feature representations, with limited benefit from slide-level aggregation, indicating aggregation may be unnecessary in many settings. These findings argue against a universally optimal architecture and instead support organ-resolved benchmarking, diagnosis-aware or ensemble strategies, stronger feature representations, and multimodal retrieval frameworks. Notably, even the best model achieved only $\approx 68\% \pm 21\%$ retrieval accuracy on TCGA, and some subtypes showed $0\%$ accuracy across all methods, highlighting fundamental limitations of morphology-based representations and the need for substantial progress before reliable clinical deployment.

Chest computed tomography (CT) is central to the detection and management of thoracic disease, yet the growing scale and complexity of volumetric imaging increasingly exceed what can be addressed by scan-level prediction alone. Clinically useful AI for CT must not only recognize disease across the whole volume, but also localize abnormalities and provide interpretable visual evidence. Existing vision-language foundation models typically compress scans and reports into global image-text representations, limiting their ability to preserve spatial evidence and support clinically meaningful interpretation. Here we developed EXACT, an explainable anomaly-aware foundation model for three-dimensional chest CT that learns spatially resolved representations from paired clinical scans and radiology reports. EXACT was pre-trained on 25,692 CT-reports pairs using anatomy-aware weak supervision, jointly learning organ segmentation and multi-instance anomaly localization without manual voxel-level annotations. The resulting organ-specific anomaly-aware maps assign each voxel a disease-specific anomaly score confined to its corresponding anatomy, jointly encoding lesion extent and organ-level context. In retrospective multinational and multi-center evaluations, EXACT showed broad and consistent improvements across clinically relevant CT tasks, spanning multi-disease diagnosis, zero-shot anomaly localization, downstream adaptation, and visually grounded report generation, outperforming existing three-dimensional medical foundation models. By transforming routine clinical CT scans and free-text reports into explainable voxel-level representations, EXACT establishes a scalable paradigm for trustworthy volumetric medical AI.

Emergent intelligence have played a major role in the modern AI development. While existing studies primarily rely on empirical observations to characterize this phenomenon, a rigorous theoretical framework remains underexplored. This study attempts to develop a mathematical approach to formalize emergent intelligence from the perspective of limit theory. Specifically, we introduce a performance function E(N, P, K), dependent on data size N, model size P and training steps K, to quantify intelligence behavior. We posit that intelligence emerges as a transition from finite to effectively infinite knowledge, and thus recast emergent intelligence as existence of the limit $\lim_{N,P,K \to \infty} \mathcal{E}(N,P,K)$, with emergent abilities corresponding to the limiting behavior. This limit theory helps reveal that emergent intelligence originates from the existence of a parameter-limit architecture (referred to as the limit architecture), and that emergent intelligence rationally corresponds to the learning behavior of this limit system. By introducing tools from nonlinear Lipschitz operator theory, we prove that the necessary and sufficient conditions for existence of the limit architecture. Furthermore, we derive the scaling law of foundation models by leveraging tools of Lipschitz operator and covering number. Theoretical results show that: 1) emergent intelligence is governed by three key factors-training steps, data size and the model architecture, where the properties of basic blocks play a crucial role in constructing foundation models; 2) the critical condition Lip(T)=1 for emergent intelligence provides theoretical support for existing findings. 3) emergent intelligence is determined by an infinite-dimensional system, yet can be effectively realized in practice through a finite-dimensional architecture. Our empirical results corroborate these theoretical findings.

Deploying machine learning models across diverse well portfolios requires generalisation to wells with design parameters outside the training distribution. Current data-driven approaches to virtual flow metering (VFM) and bottomhole estimation typically treat each well independently or ignore the influence of well design on operational behaviour. We present WISE (Well Intelligence and Systems Engineering Foundation Model), a design-aware, physics-informed multi-task model that integrates three complementary mechanisms: Feature-wise Linear Modulation (FiLM) and cross-modal attention to condition operational embeddings on well design parameters; multi-task learning for simultaneous prediction of flow rates, bottomhole conditions, and flow regime classification; and structural mass conservation with soft physics constraints derived from well engineering principles. Evaluation on the ManyWells benchmark (2000 simulated wells, $10^6$ data points) demonstrates that design-aware models reduce VFM prediction error by up to $13\times$ compared to design-unaware baselines, and that physics constraints reduce negative flow predictions by 65%. Flow regime classification achieves 97.7% bottomhole accuracy, providing continuous well integrity monitoring without additional sensors. The methodology transfers to real operational data from five Equinor Volve producers (oil rate $R^2 = 0.89$, bottomhole pressure $R^2 = 0.98$, water rate $R^2 = 0.97$). The trained model additionally serves as a fast surrogate for integrity-aware well design optimisation over a 24-dimensional design space, with more than $1000\times$ speedup over drift-flux simulations. These results demonstrate that design awareness, physics enforcement, and multi-task learning are essential and complementary ingredients for foundation models intended to operate across large well portfolios.

The vast and underexplored ocean plays a critical role in regulating global climate and supporting marine biodiversity, yet artificial intelligence has so far delivered limited impact in this domain due to a fundamental data bottleneck. Specifically, ocean data are highly fragmented across disparate sources and inherently exhibit multi-modal, high-noise, and weakly labeled characteristics, lacking unified schemas and semantic alignment. Although Multimodal Large Language Models (MLLMs) have achieved remarkable success in general domains, their application to ocean science remains severely constrained by the absence of large-scale, well-aligned multimodal datasets tailored to marine environments. To bridge this gap, we introduce OceanPile, a large-scale multimodal corpus designed for ocean foundation models. It comprises three key components: OceanCorpus, a unified collection integrating sonar data, underwater imagery, marine science visuals, and scientific text from diverse authoritative sources; OceanInstruction, a high-quality instruction dataset synthesized via a novel pipeline guided by a hierarchical Ocean Concept Knowledge Graph; and OceanBenchmark, a manually curated evaluation benchmark for rigorous assessment. We establish a multi-stage quality control process to ensure scientific validity and alignment across modalities. Experimental validation demonstrates significant performance improvements for models trained on our data. All datasets are publicly released to advance the field of marine artificial intelligence and empower domain-specific MLLMs.

Scaling context length is reshaping large-model development, yet full-attention Transformers suffer from prohibitive computation and inference bottlenecks at long sequences. A key challenge is to design foundation models that maintain performance and long-context efficiency with minimal training overhead. We introduce SpikingBrain2.0 (SpB2.0), a 5B model that advances both architecture and training efficiency of its predecessor. Our contributions are two-fold. (1) Architectural Innovation: We propose Dual-Space Sparse Attention (DSSA), an inter-layer hybrid of Sparse Softmax Attention (MoBA) and Sparse Linear Attention (SSE), achieving an improved performance-efficiency trade-off for long-context modeling. SpB2.0 further supports dual quantization paths: INT8-Spiking coding enables sparse event-driven computation, while FP8 coding accelerates inference on modern GPUs. (2) Enhanced Training Strategy: We develop an optimized Transformer-to-Hybrid (T2H) pipeline with dual conversion paths for LLMs and VLMs using curated open-source data. Empirically, SpB2.0-5B and SpB2.0-VL-5B recover most of the base Transformer (Qwen3-4B) capability with under 7k A100 GPU hours. SpB2.0 achieves a 10.13x TTFT speedup at 4M context and supports over 10M tokens on 8 A100 GPUs under vLLM, where full-attention models exceed memory limits. It also demonstrates strong cross-platform compatibility, enabling FP8 GPU inference (2.52x speedup at 250k) and efficient neuromorphic execution (64.31% sparsity, with 70.6% and 46.5% area and power reduction at 500MHz). Overall, SpikingBrain2.0 provides a practical pathway for lightweight, multimodal, spiking foundation models, highlighting the potential of combining brain-inspired mechanisms with efficient architectures for resource-constrained and edge scenarios.

The emergence of large-scale pretrained foundation models has transformed computer vision, enabling strong performance across diverse downstream tasks. However, their potential for physics-based inverse problems, such as accelerated cardiac MRI reconstruction, remains largely underexplored. In this work, we investigate whether natural-domain foundation models can serve as effective image priors for accelerated cardiac MRI reconstruction, and compare the performance obtained against domain-specific counterparts such as BiomedCLIP. We propose an unrolled reconstruction framework that incorporates pretrained, frozen visual encoders, such as CLIP, DINOv2, and BiomedCLIP, within each cascade to guide the reconstruction process. Through extensive experiments, we show that while task-specific state-of-the-art reconstruction models such as E2E-VarNet achieve superior performance in standard in-distribution settings, foundation-model-based approaches remain competitive. More importantly, in challenging cross-domain scenarios, where models are trained on cardiac MRI and evaluated on anatomically distinct knee and brain datasets--foundation models exhibit improved robustness, particularly under high acceleration factors and limited low-frequency sampling. We further observe that natural-image-pretrained models, such as CLIP, learn highly transferable structural representations, while domain-specific pretraining (BiomedCLIP) provides modest additional gains in more ill-posed regimes. Overall, our results suggest that pretrained foundation models offer a promising source of transferable priors, enabling improved robustness and generalization in accelerated MRI reconstruction.

Driven by the transition towards a climate-neutral energy system, accurate energy time series forecasting is critical for planning and operation. Yet, it remains largely a dataset-specific task, requiring comprehensive training data, limiting scalability, and resulting in high model development and maintenance effort. Recently, foundation models that aim to learn generalizable patterns via extensive pretraining have shown superior performance in multiple prediction tasks. Despite their success and strong potential to address challenges in energy forecasting, their application in this domain remains largely unexplored. We address this gap by presenting the Foundation Models in Energy Time Series Forecasting (FETS) benchmark. We (1) provide a structured overview of energy forecasting use cases along three main dimensions: stakeholders, attributes, and data categories; (2) collect and analyze 54 datasets across 9 data categories, guided by typical stakeholder interests; (3) benchmark foundation models against classical machine learning approaches across different forecasting settings. Foundation models consistently outperform dataset-specific optimized machine learning approaches across all settings and data categories, despite the latter having seen the full historic target data during training. In particular, covariate-informed foundation models achieve the strongest performance. Further analysis reveals a strong correlation between predictive performance and spectral entropy, performance saturation beyond a certain context length, and improved performance at higher aggregation levels such as national load, district heating, and power grid data. Overall, our findings highlight the strong potential of foundation models as scalable and generalizable forecasting solutions for the energy domain, particularly in data-constrained and privacy-sensitive settings.

Low-rank adaptation (LoRA) has emerged as the de facto standard for parameter-efficient fine-tuning (PEFT) of foundation models, enabling the adaptation of billion-parameter networks with minimal computational and memory overhead. Despite its empirical success and rapid proliferation of variants, it remains elusive which architectural choices, optimization techniques, and deployment constraints should guide practical method selection. This overview revisits LoRA through the lens of signal processing (SP), bridging modern adapter designs with classical low-rank modeling tools and inverse problems, as well as highlighting how SP principles can inform principled advances of fine-tuning approaches. Rather than providing a comprehensive enumeration and empirical comparisons of LoRA variants, emphasis is placed on the technical mechanisms underpinning these approaches to justify their effectiveness. These advances are categorized into three complementary axes: architectural design, efficient optimization, and pertinent applications. The first axis builds on singular value decomposition (SVD)-based factorization, rank-augmentation constructions, and cross-layer tensorization, while the second axis deals with initialization, alternating solvers, gauge-invariant optimization, and parameterization-aware methods. Beyond fine-tuning, emerging applications of LoRA are accounted across the entire lifecycle of large models, ranging from pre- and post-training to serving/deployment. Finally, open research directions are outlined at the confluence of SP and deep learning to catalyze a bidirectional frontier: classical SP tools provide a principled vocabulary for designing principled PEFT methods, while the unique challenges facing modern deep learning, especially the overwhelming scale and prohibitive overhead, also offer new research lines benefiting the SP community in return.

Robotic autonomy in open-world environments is fundamentally limited by insufficient data diversity and poor cross-embodiment generalization. Existing robotic datasets are often limited in scale and task coverage, while relatively large differences across robot embodiments impede effective behavior knowledge transfer. To address these challenges, we propose JoyAI-RA, a vision-language-action (VLA) embodied foundation model tailored for generalizable robotic manipulation. JoyAI-RA presents a multi-source multi-level pretraining framework that integrates web data, large-scale egocentric human manipulation videos, simulation-generated trajectories, and real-robot data. Through training on heterogeneous multi-source data with explicit action-space unification, JoyAI-RA effectively bridges embodiment gaps, particularly between human manipulation and robotic control, thereby enhancing cross-embodiment behavior learning. JoyAI-RA outperforms state-of-the-art methods in both simulation and real-world benchmarks, especially on diverse tasks with generalization demands.

The integration of single-cell proteomic data is often hindered by the fragmented nature of targeted antibody panels. To address this limitation, we introduce scpFormer, a transformer-based foundation model designed for single-cell proteomics. Pre-trained on over 390 million cells, scpFormer replaces standard index-based tokenization with a continuous, sequence-anchored approach. By combining Evolutionary Scale Modeling (ESM) with value-aware expression embeddings, it dynamically maps variable panels into a shared semantic space without artificial discretization. We demonstrate that scpFormer generates global cell representations that perform competitively in large-scale batch integration and unsupervised clustering. Moreover, its open-vocabulary architecture facilitates in silico panel expansion, assisting in the reconstruction of biological manifolds in sparse clinical datasets. Finally, this learned protein co-expression logic is transferable to bulk-omics tasks, supporting applications like cancer drug response prediction. scpFormer provides a versatile, panel-agnostic framework to facilitate scalable biomarker discovery and precision oncology.

Vision-Language-Action (VLA) models drive next-generation autonomous systems, but training them requires scalable, high-quality annotations from complex environments. Current cloud pipelines rely on generic vision-language models (VLMs) that lack geometric reasoning and domain semantics due to their 2D image-text pretraining. To address this mismatch, we propose XEmbodied, a cloud-side foundation model that endows VLMs with intrinsic 3D geometric awareness and interaction with physical cues (e.g., occupancy grids, 3D boxes). Instead of treating geometry as auxiliary input, XEmbodied integrates geometric representations via a structured 3D Adapter and distills physical signals into context tokens using an Efficient Image-Embodied Adapter. Through progressive domain curriculum and reinforcement learning post-training, XEmbodied preserves general capabilities while demonstrating robust performance across 18 public benchmarks. It significantly improves spatial reasoning, traffic semantics, embodied affordance, and out-of-distribution generalization for large-scale scenario mining and embodied VQA.

AI coding assistants increasingly generate code alongside tests. How developers structure test code, whether inline with the implementation or in separate blocks, has traditionally been a matter of testing philosophy. We investigate whether this choice affects AI code generation quality. We conduct a large-scale empirical study (830+ generated files, 12 models, 3 providers) using SEGA, a three-dimensional evaluation framework measuring Determinism, Preservation, and Correctness. Comparing inline test syntax (Python doctests) against separated test syntax (Rust #[test] blocks) on a d-ary heap implementation, we find that: (1) inline tests yield near-perfect preservation (100%) and correctness (92-100%) across all models; (2) separated tests expose stark model-tier gaps (0-100% correctness) and independence between preservation and correctness; (3) model behavior evolves across generations, and notably one model breaks the test suppression pattern of its three predecessors; (4) mechanistic analysis on 7 open-source architectures (6 transformers and a gated-linear Recurrent Neural Network (RNN)) reveals inline test markers receive 2.8-4.4$\times$ stronger attention in 5/7 models, with causal validation via knockout and steering experiments on the 4 code-specialized transformers and RWKV-6; the co-location mechanism extends to a non-transformer architecture, suggesting the design recommendation is robust to future architectural shifts. In the Foundation Model era, test syntax structure is a software design concern: co-locating tests with implementation code produces measurably better AI-generated code. This arxiv long version includes appendices that further qualify the effect as bounded by both model capability and programming language.

Accurate machine-learning models for aerodynamic prediction are essential for accelerating shape optimization, yet remain challenging to develop for complex three-dimensional configurations due to the high cost of generating training data. This work introduces a methodology for efficiently constructing accurate surrogate models for design purposes by first pre-training a large-scale model on diverse geometries and then fine-tuning it with a few more detailed task-specific samples. A Transformer-based architecture, AeroTransformer, is developed and tailored for large-scale training to learn aerodynamics. The methodology is evaluated on transonic wings, where the model is pre-trained on SuperWing, a dataset of nearly 30000 samples with broad geometric diversity, and subsequently fine-tuned to handle specific wing shapes perturbed from the Common Research Model. Results show that, with 450 task-specific samples, the proposed methodology achieves 0.36% error on surface-flow prediction, reducing 84.2% compared to training from scratch. The influence of model configurations and training strategies is also systematically studied to provide guidance on effectively training and deploying such models under limited data and computational budgets. To facilitate reuse, we release the datasets and the pre-trained models at https://github.com/tum-pbs/AeroTransformer. An interactive design tool is also built on the pre-trained model and is available online at https://webwing.pbs.cit.tum.de.

In this work, we introduce DifFoundMAD, a parameter-efficient D-MAD framework that exploits the generalisation capabilities of vision foundation models (FM) to capture discrepancies between suspected morphs and live capture images. In contrast to conventional D-MAD systems that rely on face recognition embeddings or handcrafted feature differences, DifFoundMAD follows the standard differential paradigm while replacing the underlying representation space with embeddings extracted from FMs. By combining lightweight finetuning with class-balanced optimisation, the proposed method updates only a small subset of parameters while preserving the rich representational priors of the underlying FMs. Extensive cross-database evaluations on standard D-MAD benchmarks demonstrate that DifFoundMAD achieves consistent improvements over state-of-the-art systems, particularly at the strict security levels required in operational deployments such as border control: The error rates reported in the current state-of-the-art were reduced from 6.16% to 2.17% for high-security levels using DifFoundMAD.

Automated polyp segmentation is critical for early colorectal cancer detection and its prevention, yet remains challenging due to weak boundaries, large appearance variations, and limited annotated data. Lightweight segmentation models such as U-Net, U-Net++, and PraNet offer practical efficiency for clinical deployment but struggle to capture the rich semantic and structural cues required for accurate delineation of complex polyp regions. In contrast, large Vision Foundation Models (VFMs), including SAM, OneFormer, Mask2Former, and DINOv2, exhibit strong generalization but transfer poorly to polyp segmentation due to domain mismatch, insufficient boundary sensitivity, and high computational cost. To bridge this gap, we propose \textit{\textbf{LiteBounD}, a \underline{Li}gh\underline{t}w\underline{e}ight \underline{Boun}dary-guided \underline{D}istillation} framework that transfers complementary semantic and structural priors from multiple VFMs into compact segmentation backbones. LiteBounD introduces (i) a dual-path distillation mechanism that disentangles semantic and boundary-aware representations, (ii) a frequency-aware alignment strategy that supervises low-frequency global semantics and high-frequency boundary details separately, and (iii) a boundary-aware decoder that fuses multi-scale encoder features with distilled semantically rich boundary information for precise segmentation. Extensive experiments on both seen (Kvasir-SEG, CVC-ClinicDB) and unseen (ColonDB, CVC-300, ETIS) datasets demonstrate that LiteBounD consistently outperforms its lightweight baselines by a significant margin and achieves performance competitive with state-of-the-art methods, while maintaining the efficiency required for real-time clinical use. Our code is available at https://github.com/lostinrepo/LiteBounD.

Deploying a humanoid robot to manipulate a new object has traditionally required one to two days of effort: data collection, manual annotation, 3D model acquisition, and model training. This paper presents an end-to-end rapid deployment pipeline that integrates three foundation-model components to shorten the onboarding cycle for a new object to approximately 30 minutes: (i) Roboflow-based automatic annotation to assist in training a YOLOv8 object detector; (ii) 3D reconstruction based on Meta SAM 3D, which eliminates the need for a dedicated laser scanner; and (iii) zero-shot 6-DoF pose tracking based on FoundationPose, using the SAM3D-generated mesh directly as the template. The estimated pose drives a Unity-based inverse kinematics planner, whose joint commands are streamed via UDP to a UnitreeG1 humanoid and executed through the Unitree SDK. We demonstrate detection accuracy of mAP@0.5 = 0.995, pose tracking precision of $σ< 1.05$ mm, and successful grasping on a real robot at five positions within the workspace. We further verify the generality of the pipeline on an automobile-window glue-application task. The results show that combining foundation models for perception with everyday imaging devices (e.g., smartphones) can substantially lower the deployment barrier for humanoid manipulation tasks.

Land surface temperature (LST) super-resolution is important for environmental monitoring. However, it remains challenging as coarse thermal observations severely underdetermine fine-scale structure. In this paper, we propose Earth Foundation Model-guided Diffusion (EFDiff), a novel framework for super-resolution under extreme spatial degradation. EFDiff uses the Prithvi-EO-2.0 Earth foundation model to encode high-resolution multispectral reflectance into geospatial embeddings, which are injected into the denoising network via cross-attention to guide fine-scale reconstruction from highly degraded observations. We study two variants, EFDiff-$ε$ and EFDiff-$x_0$, which offer complementary trade-offs between perceptual realism and pixel-level fidelity. We evaluate EFDiff under an extreme $32\times$ scale gap using a globally diverse benchmark comprising 242,416 co-registered Landsat thermal-reflectance patches. Results show that EFDiff consistently outperforms baseline methods and that cross-attention conditioning by EFM is more effective than HLS channel concatenation. Although we present EFDiff in the context of LST super-resolution, the framework is broadly applicable to remote sensing problems in which pretrained geospatial representations can guide generative reconstruction.

Molecular property prediction integrates quantum chemistry, cheminformatics, and deep learning to connect molecular structure with physicochemical and biological behavior. This survey traces four complementary paradigms, including Quantum, Descriptor Machine Learning, Geometric Deep Learning, and Foundation Models, and outlines a unified taxonomy linking molecular representations, model architectures, and interdisciplinary applications. Benchmark analyses integrate evidence from both widely used datasets and datasets reflecting industry perspectives, encompassing quantum, physicochemical, physiological, and biophysical domains. The survey examines current standards in data curation, splitting strategies, and evaluation protocols, highlighting challenges including inconsistent stereochemistry, heterogeneous assay sources, and reproducibility limitations under random or poorly defined splits. These observations motivate the modernization of benchmark design toward more transparent, time- and scaffold-aware methodologies. We further propose three forward-looking directions: (i) physics-aware learning embedding quantum consistency, (ii) uncertainty-calibrated foundation models for trustworthy inference, and (iii) realistic multimodal benchmark ecosystems integrating computational and experimental data. Repository: https://github.com/Zongru-Li/Survey-and-Benchmarks-of-DL-for-Molecular-Property-Prediction-in-the-Foundation-Model-Era.

EEG foundation models (EFMs) achieve strong cross-subject and cross-task generalization through large-scale pretraining and downstream fine-tuning. Through empirical analysis, we observe that (i) task-adapted EFMs provide strong decoding performance but incur substantial overhead when retained as inference backbones, making knowledge distillation a natural route for optimizing compact students; and (ii) direct distillation from a fixed teacher representation underutilizes EFM knowledge, as task-discriminative information is distributed across intermediate layers rather than concentrated in the final layer. These observations motivate DLink (Distilling Layer-wise and Dominant Knowledge), a spectrally guided distillation framework with input-conditioned layer routing for transferring EFM knowledge into compact students. DLink uses a lightweight router to aggregate teacher layers for each input, and aligns magnitude and phase spectra to mitigate compression-induced spectral distortion in learned representations. The routed teacher knowledge is internalized by a project-then-compress student; the teacher and router are used only during training. Experiments on four EEG benchmarks show that DLink improves matched compact students and remains competitive with lightweight baselines, narrowing the gap to fine-tuned EFMs while substantially reducing parameters, FLOPs, and CPU-only inference latency.

As power systems transition toward renewable-rich and inverter-dominated operations, accurate time-domain dynamic analysis becomes increasingly critical. Such analysis supports key operational tasks, including transient stability assessment, dynamic security analysis, contingency screening, and post-fault trajectory evaluation. In practice, these tasks may operate under several challenges, including unknown and time-varying system parameters, privacy constraints on data sharing, and the need for fast online inference. Existing learning-based approaches are typically trained for individual systems and therefore lack generalization across operating conditions and physical parameters. Hence, this paper proposes LArge Scale Small ODE (LASS)-ODE-Power, a learning framework for general-purpose time-domain prediction. The proposed approach leverages large-scale pretraining on more than 40 GB of DAE or ordinary differential-equation (ODE) trajectories to learn transferable representations. The resulting model supports trajectory prediction from short measurement prefixes across diverse dynamic regimes, including electromechanical and inverter-driven systems. Hence, the model can be directly used without data sharing in a zero-shot setting. In addition, the proposed architecture incorporates parallel and linearized computation to achieve fast inference. Moreover, to enhance task-specific performance in power systems, a specialized fine-tuning strategy is developed based on approximately 1 GB of heterogeneous power-system dynamic data. Extensive experiments over diverse power-system simulation scenarios demonstrate that LASS-ODE-Power consistently outperforms existing learning-based models in trajectory prediction accuracy with efficient inference.

A vision foundation model outputs an embedding vector for an image, which can be affected by common editing operations (e.g., JPEG compression, brightness, contrast adjustments). These common perturbations alter embedding vectors and may impact the performance of downstream tasks using these embeddings. In this work, we present the first systematic study on foundation models' robustness to such perturbations. We propose three robustness metrics and formulate five desired mathematical properties for these metrics, analyzing which properties they satisfy or violate. Using these metrics, we evaluate six industry-scale foundation models (OpenAI, Meta) across nine common perturbation categories, finding them generally non-robust. We also show that common perturbations degrade downstream application performance (e.g., classification accuracy) and that robustness values can predict performance impacts. Finally, we propose a fine-tuning approach to improve robustness without sacrificing utility.

Over the recent years, the field of robotics has been undergoing a transformative paradigm shift from fixed, single-task, domain-specific solutions towards adaptive, multi-function, general-purpose agents, capable of operating in complex, open-world, and dynamic environments. This tremendous advancement is primarily driven by the emergence of Foundation Models (FMs), i.e., large-scale neural-network architectures trained on massive, heterogeneous datasets that provide unprecedented capabilities in multi-modal understanding and reasoning, long-horizon planning, and cross-embodiment generalization. In this context, the current study provides a holistic, systematic, and in-depth review of the research landscape of FMs in robotics. In particular, the evolution of the field is initially delineated through five distinct research phases, spanning from the early incorporation of Natural Language Processing (NLP) and Computer Vision (CV) models to the current frontier of multi-sensory generalization and real-world deployment. Subsequently, a highly-granular taxonomic investigation of the literature is performed, examining the following key aspects: a) the employed FM types, including LLMs, VFMs, VLMs, and VLAs, b) the underlying neural-network architectures, c) the adopted learning paradigms, d) the different learning stages of knowledge incorporation, e) the major robotic tasks, and f) the main real-world application domains. For each aspect, comparative analysis and critical insights are provided. Moreover, a report on the publicly available datasets used for model training and evaluation across the considered robotic tasks is included. Furthermore, a hierarchical discussion on the current open challenges and promising future research directions in the field is incorporated.

Large-scale renewable energy deployment introduces pronounced volatility into the electricity system, turning grid operation into a complex stochastic optimization problem. Accurate electricity price forecasting (EPF) is essential not only to support operational decisions, such as optimal bidding strategies and balancing power preparation, but also to reduce economic risk and improve market efficiency. Probabilistic forecasts are particularly valuable because they quantify uncertainty stemming from renewable intermittency, market coupling, and regulatory changes, enabling market participants to make informed decisions that minimize losses and optimize expected revenues. However, it remains an open question which models to employ to produce accurate forecasts. Should these be task-specific machine learning (ML) models or Time Series Foundation Models (TSFMs)? In this work, we compare four models for day-ahead probabilistic EPF (PEPF) in European bidding zones: a deterministic NHITS backbone with Quantile-Regression Averaging (NHITS+QRA) and a conditional Normalizing-Flow forecaster (NF) are compared with two TSFMs, namely Moirai and ChronosX. On the one hand, we find that TSFMs outperform task-specific deep learning models trained from scratch in terms of CRPS, Energy Score, and predictive interval calibration across market conditions. On the other hand, we find that well-configured task-specific models, particularly NHITS combined with QRA, achieve performance very close to TSFMs, and in some scenarios, such as when supplied with additional informative feature groups or adapted via few-shot learning from other European markets, they can even surpass TSFMs. Overall, our findings show that while TSFMs offer expressive modeling capabilities, conventional models remain highly competitive, emphasizing the need to weigh computational expense against marginal performance improvements in PEPF.

Current fMRI foundation models primarily rely on a limited range of brain states and mismatched pretraining tasks, restricting their ability to learn generalized representations across diverse brain states. We present Brain-DiT, a universal multi-state fMRI foundation model pretrained on 349,898 sessions from 24 datasets spanning resting, task, naturalistic, disease, and sleep states. Unlike prior fMRI foundation models that rely on masked reconstruction in the raw-signal space or a latent space, Brain-DiT adopts metadata-conditioned diffusion pretraining with a Diffusion Transformer (DiT), enabling the model to learn multi-scale representations that capture both fine-grained functional structure and global semantics. Across extensive evaluations and ablations on 7 downstream tasks, we find consistent evidence that diffusion-based generative pretraining is a stronger proxy than reconstruction or alignment, with metadata-conditioned pretraining further improving downstream performance by disentangling intrinsic neural dynamics from population-level variability. We also observe that downstream tasks exhibit distinct preferences for representational scale: ADNI classification benefits more from global semantic representations, whereas age/sex prediction comparatively relies more on fine-grained local structure.

Feed-forward foundation models for multi-view 3-dimensional (3D) reconstruction have been trained on large-scale datasets of perspective images; when tested on wide field-of-view images, e.g., from a fisheye camera, their performance degrades. This degradation arises from changes in spatial arrangements of pixels induced by the non-linear projection model that maps 3D points onto the 2D image plane. While one may surmise that training on fisheye images would resolve this problem, there are far fewer fisheye images with ground truth than perspective images, which limits generalization. To enable inference on imagery exhibiting high radial distortion, we propose \textit{Fisheye3R}, a novel adaptation framework that extends these multi-view 3D reconstruction foundation models to natively accommodate fisheye inputs without performance regression on perspective images. To address the scarcity of fisheye images and ground truth, we introduce flexible learning schemes that support self-supervised adaptation using only unlabeled perspective images and supervised adaptation without any fisheye training data. Extensive experiments across three foundation models, including VGGT, $π^3$, and MapAnything, demonstrate that our approach consistently improves camera pose, depth, point map, and field-of-view estimation on fisheye images. Code is available at https://github.com/android-xr/fisheye3r.

Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL). However, many of these models rely on architectures that offer limited interpretability, a critical issue in high-stakes domains such as medical imaging. We propose \model, a foundation model that is interpretable-by-design via a BagNet backbone whose small receptive fields generate class evidence maps that are faithful to the model's decision-making process. Additionally, \model{} incorporates a $2D$ projection layer during pretraining that enables direct visualization of the representation space, providing a dataset-level view of the learned structure including meaningful clinical clusters as well as potential spurious correlations. We trained \model{} on over 800,000 color fundus photographs from various sources to learn generalizable representations for different downstream tasks. Our model achieves performance comparable to RETFound, which has $16\times$ more parameters, while providing interpretable predictions on out-of-distribution data. These results suggest that large-scale SSL pretraining paired with inherent interpretability can lead to robust representations for retinal imaging. Code and pretrained models are available at \href{https://anonymous.4open.science/r/dual-ifm-3D5A/README.md}{www.anonymous.4open.science/dual-IFM}.

Material classification has emerged as a critical task in computer vision and graphics, supporting the assignment of accurate material properties to a wide range of digital and real-world applications. While traditionally framed as an image classification task, this domain faces significant challenges due to the scarcity of annotated data, limiting the accuracy and generalizability of trained models. Recent advances in vision-language foundation models (VLMs) offer promising avenues to address these issues, yet existing solutions leveraging these models still exhibit unsatisfying results in material recognition tasks. In this work, we propose a novel framework that effectively harnesses foundation models to overcome data limitations and enhance classification accuracy. Our method integrates two key innovations: (a) a robust image generation and auto-labeling pipeline that creates a diverse and high-quality training dataset with material-centric images, and automatically assigns labels by fusing object semantics and material attributes in text prompts; (b) a prior incorporation strategy to distill information from VLMs, combined with a joint fine-tuning method that optimizes a pre-trained vision foundation model alongside VLM-derived priors, preserving broad generalizability while adapting to material-specific features. Extensive experiments demonstrate significant improvements on multiple datasets. We show that our synthetic dataset effectively captures the characteristics of real world materials, and the integration of priors from vision-language models significantly enhances the final performance. The source code and dataset will be released.

Artificial intelligence built on large foundation models has transformed language understanding, computer vision, and reasoning, yet these systems remain isolated and cannot readily share their capabilities. Coordinating the complementary strengths of independently developed, black-box foundation models is essential for trustworthy intelligent systems, yet no established method exists. Here we show that such coordination can be achieved through a meta-ensemble framework termed StackingNet, which aggregates the output predictions of independent models at inference. StackingNet improves accuracy, reduces individual-model error and group-wise disparities, ranks model reliability, and identifies or prunes models that degrade performance, all without access to internal parameters or training data. Across language comprehension, visual attribute estimation, and academic paper rating, it consistently outperforms individual models and classic ensembles, with gains that persist when the base models are uniformly strong. These gains stem from variance reduction and consensus alignment among independent models rather than from any emergent group cognition, and they widen as the model pool grows more diverse. By turning model diversity from a source of inconsistency into a resource for cooperation, StackingNet offers a practical path toward coordinated artificial intelligence, where progress emerges not only from larger single models but from principled cooperation among many specialized ones.

Relational Foundation Models (RFMs) facilitate data-driven decision-making by learning from complex multi-table databases. However, the diverse relational databases needed to train such models are rarely public due to privacy constraints. While there are methods to generate synthetic tabular data of arbitrary size, incorporating schema structure and primary-foreign key connectivity for multi-table generation remains challenging. Here we introduce PLUREL, a framework to synthesize multi-tabular relational databases from scratch. In a step-by-step fashion, PLUREL models (1) schemas with directed graphs, (2) inter-table primary-foreign key connectivity with bipartite graphs, and, (3) feature distributions in tables via conditional causal mechanisms. The design space across these stages supports the synthesis of a wide range of diverse databases, while being computationally lightweight. Using PLUREL, we observe for the first time that (1) RFM pretraining loss exhibits power-law scaling with the number of synthetic databases and total pretraining tokens, (2) scaling the number of synthetic databases improves generalization to real databases, and (3) synthetic pretraining yields strong base models for continued pretraining on real databases. Overall, our framework and results position synthetic data scaling as a promising paradigm for RFMs.

Visual Foundation Models (VFMs), such as DINO and CLIP, excel in semantic understanding of images but exhibit limited spatial reasoning capabilities, which limits their applicability to embodied systems. As a result, recent work incorporates some 3D tasks (such as depth estimation) into VFM training. However, VFM performance remains inconsistent across other spatial tasks, raising the question of whether these models truly have spatial awareness or overfit to specific 3D objectives. To address this question, we introduce the Spatial Relation Recognition Task (SpaRRTa) benchmark, which evaluates the ability of VFMs to identify relative positions of objects in the image. Unlike traditional 3D objectives that focus on precise metric prediction (e.g., surface normal estimation), SpaRRTa probes a fundamental capability underpinning more advanced forms of human-like spatial understanding. SpaRRTa generates an arbitrary number of photorealistic images with diverse scenes and fully controllable object arrangements, along with freely accessible spatial annotations. Evaluating a range of state-of-the-art VFMs, we reveal significant disparities between their spatial reasoning abilities. Through our analysis, we provide insights into the mechanisms that support or hinder spatial awareness in modern VFMs. We hope that SpaRRTa will serve as a useful tool for guiding the development of future spatially aware visual models.

With the rise of large-scale foundation models, efficiently adapting them to downstream tasks remains a central challenge. Linear probing, which freezes the backbone and trains a lightweight head, is computationally efficient but often restricted to last-layer representations. We show that task-relevant information is distributed across the network hierarchy rather than encoded solely in the last layers. To leverage this distribution of information, we apply an attentive probing mechanism that dynamically fuses representations from all layers of a Vision Transformer. This attentive layer fusion (ALF) learns to identify the most relevant layers for a target task and combines low-level structural cues with high-level semantic abstractions. Across 20 diverse datasets and multiple pretrained foundation models, ALF achieves consistent, substantial gains over standard linear probes. Attention heatmaps further reveal that tasks different from the pre-training domain benefit most from intermediate representations. Overall, our findings underscore the value of intermediate layers and demonstrate a principled, task-aware approach for unlocking their potential for probing-based adaptation.

Predicting river flow in places without streamflow records is challenging because basins respond differently to climate, terrain, vegetation, and soils. Traditional basin attributes describe some of these differences, but they cannot fully represent the complexity of natural environments. This study examines whether AlphaEarth Foundation embeddings, which are learned from large collections of satellite images rather than designed by experts, offer a more informative way to describe basin characteristics. These embeddings summarize patterns in vegetation, land surface properties, and long-term environmental dynamics. We find that models using them achieve higher accuracy when predicting flows in basins not used for training, suggesting that they capture key physical differences more effectively than traditional attributes. We further investigate how selecting appropriate donor basins influences prediction in ungauged regions. Similarity based on the embeddings helps identify basins with comparable environmental and hydrological behavior, improving performance, whereas adding many dissimilar basins can reduce accuracy. The results show that satellite-informed environmental representations can strengthen hydrological forecasting and support the development of models that adapt more easily to different landscapes.

While foundation models in radiology are expected to be applied to various clinical tasks, computational cost constraints remain a major challenge when training on 3D-CT volumetric data. In this study, we propose TotalFM, a radiological foundation model that efficiently learns the correspondence between 3D-CT images and linguistic expressions based on the concept of organ separation, utilizing a large-scale dataset of 140,000 series. By automating the creation of organ volume and finding-sentence pairs through segmentation techniques and Large Language Model (LLM)-based radiology report processing, and by combining self-supervised pre-training via VideoMAE with contrastive learning using volume-text pairs, we aimed to balance computational efficiency and representation capability. In zero-shot organ-wise lesion classification tasks, the proposed model achieved higher F1 scores in 83% (5/6) of organs compared to CT-CLIP and 64% (9/14) of organs compared to Merlin. These results suggest that the proposed model exhibits high generalization performance in a clinical evaluation setting using actual radiology report sentences. Furthermore, in zero-shot finding-wise lesion classification tasks, our model achieved a higher AUROC in 83% (25/30) of finding categories compared to Merlin. We also confirmed performance comparable to existing Vision-Language Models (VLMs) in radiology report generation tasks. Our results demonstrate that the organ-separated learning framework can serve as a realistic and effective design guideline for the practical implementation of 3D-CT foundation models. The source code and pretrained models are publicly available at https://github.com/jichi-labo/TotalFM.

Foundation models are vital tools in various Computer Vision applications. They take as input a single RGB image and output a deep feature representation that is useful for various applications. However, in case we have multiple views of the same 3D scene, they operate on each image independently and do not always produce consistent features for the same 3D point. We propose a way to convert a Foundation Model into a Multi-View Foundation Model. Such a model takes as input a set of images and outputs a feature map for each image such that the features of corresponding points are as consistent as possible. This approach bypasses the need to build a consistent 3D model of the features and allows direct manipulation in the image space. Specifically, we show how to augment Transformers-based foundation models (i.e., DINO, SAM, CLIP) with intermediate 3D-aware attention layers that help match features across different views. As leading examples, we show surface normal estimation and multi-view segmentation tasks. Quantitative experiments show that our method improves feature matching considerably compared to current foundation models.

Foundation Models (FMs) are increasingly integrated into remote sensing (RS) pipelines. These models include unimodal vision encoders and multimodal architectures. FMs are adapted to diverse perception tasks, such as image classification, change detection, and visual question answering. However, selecting the most suitable remote sensing foundation model (RSFM) for a specific task remains challenging due to scattered documentation, heterogeneous formats, and complex deployment constraints. To address this, we first introduce the RSFM Database (RS-FMD), the first structured and schema-guided resource covering over 160 RSFMs trained on various data modalities, spanning different spatial, spectral, and temporal resolutions, considering different learning paradigms. Built upon RS-FMD, we further present REMSA, a constraint-aware agent that enables automated RSFM selection from natural language queries. REMSA combines structured FM metadata retrieval with a task-driven decision workflow. In detail, it interprets user input, clarifies missing constraints, ranks models via in-context learning, and provides transparent justifications. Our system supports various RS tasks and data modalities, enabling personalized, reproducible, and efficient FM selection. To evaluate REMSA, we construct a benchmark of 100 expert-verified RS query scenarios. Each query is evaluated across 4 systems and 3 LLM backbones, with the top-3 selected models manually assessed by domain experts. This results in 3,000 expert-scored task--system--model configurations under our novel expert-centered evaluation protocol. REMSA outperforms multiple baselines, showing its practical utility in real decision-making applications. REMSA operates entirely on publicly available metadata of open source RSFMs, without accessing private or sensitive data.

Foundation models have transformed machine learning for language and vision, but achieving comparable impact in physical simulation remains a challenge. Data heterogeneity and unstable long-term dynamics inhibit learning from sufficiently diverse dynamics, while varying resolutions and dimensionalities challenge efficient training on modern hardware. Through empirical and theoretical analysis, we incorporate new approaches to mitigate these obstacles, including a harmonic-analysis-based stabilization method, load-balanced distributed 2D and 3D training strategies, and compute-adaptive tokenization. Using these tools, we develop Walrus, a transformer-based foundation model developed primarily for fluid-like continuum dynamics. Walrus is pretrained on nineteen diverse scenarios spanning astrophysics, geoscience, rheology, plasma physics, acoustics, and classical fluids. Experiments show that Walrus outperforms prior foundation models on both short and long term prediction horizons on downstream tasks and across the breadth of pretraining data, while ablation studies confirm the value of our contributions to forecast stability, training throughput, and transfer performance over conventional approaches. Code and weights are released for community use.

While foundation models have emerged as general-purpose visual backbones, their representations are primarily optimized for semantics and lack explicit modeling of physical factors, such as reflectance, hindering their efficacy in tasks requiring explicit material reasoning. We introduce $Φ$eat$, a novel material-grounded visual backbone that encourages a representation sensitive to material identity, including reflectance and mesostructure. Instead of relying on generic data augmentations, we pretrain our model by contrasting observations of the same material under controlled variations in lighting and geometry. This encourages invariance to extrinsic factors while preserving sensitivity to intrinsic material properties. We show that the resulting representation provides strong priors for material-centric tasks, including feature-based material selection and classification. Our results demonstrate that physically inspired weak supervision is an effective strategy for learning representations tailored to material perception.

Diabetic Macular Edema (DME) is a leading cause of vision loss among patients with Diabetic Retinopathy (DR). While deep learning has shown promising results for automatically detecting this condition from fundus images, its application remains challenging due the limited availability of annotated data. Foundation Models (FM) have emerged as an alternative solution. However, it is unclear if they can cope with DME detection in particular. In this paper, we systematically compare different FM and standard transfer learning approaches for this task. Specifically, we compare the two most popular FM for retinal images-RETFound and FLAIR-and an EfficientNetB0 backbone, across different training regimes and evaluation settings in IDRiD, MESSIDOR-2 and OCT-and-Eye-FundusImages (OEFI). Results show that despite their scale, FM do not consistently outperform fine-tuned CNNs in this task. In particular, EfficientNet-B0 consistently achieves competitive or superior performance across evaluation settings, with FLAIR being the most competitive foundation model, consistently outperforming RETFound. These findings suggest that FMs do not necessarily provide an advantage for fine-grained ophthalmic tasks such as DME detection, even after fine-tuning, highlighting lightweight CNNs as strong baselines in data-scarce environments.

Large language models (LLMs) excel at operating at scale by leveraging social media and various data crawled from the web. Whereas existing corpora are diverse, their frequent lack of long-term temporal structure may however limit an LLM's ability to contextualize semantic and normative evolution of language and to capture diachronic variation. To support analysis and training for the latter, we introduce CHRONOBERG, a temporally structured corpus of English book texts spanning 250 years, curated from Project Gutenberg and enriched with a variety of temporal annotations. First, the edited nature of books enables us to quantify lexical semantic change through time-sensitive Valence-Arousal-Dominance (VAD) analysis and to construct historically calibrated affective lexicons to support temporally grounded interpretation. With the lexicons at hand, we demonstrate a need for modern LLM-based tools to better situate their detection of discriminatory language and contextualization of sentiment across various time-periods. In fact, we show how language models trained sequentially on CHRONOBERG struggle to encode diachronic shifts in meaning, emphasizing the need for temporally aware training and evaluation pipelines, and positioning CHRONOBERG as a scalable resource for the study of linguistic change and temporal generalization. Disclaimer: This paper includes language and display of samples that could be offensive to readers. Open Access: Chronoberg is available publicly on HuggingFace at ( https://huggingface.co/datasets/spaul25/Chronoberg). Code is available at (https://github.com/paulsubarna/Chronoberg).

Neural network (NN) training is inherently a large-scale matrix optimization problem, yet the matrix structure of NN parameters has long been overlooked. Recently, the optimizer Muon \citep{jordanmuon}, which explicitly exploits this structure, has gained significant attention for its strong performance in foundation model training. A key component contributing to Muon's success is matrix orthogonalization. In this paper, we propose \textit{low-rank orthogonalization}, which performs orthogonalization by leveraging the low-rank nature of gradients during NN training. Building on this, we introduce low-rank matrix-signed gradient descent (MSGD) and a low-rank variant of Muon. %Numerical experiments demonstrate the superior performance of low-rank orthogonalization, with low-rank Muon achieving promising results in GPT-2 and LLaMA pretraining---surpassing the carefully tuned vanilla Muon on tasks with large model sizes. {Numerical experiments demonstrate the advantages of low-rank orthogonalization: low-rank Muon generally matches or improves upon vanilla Muon on the GPT-2 and LLaMA pretraining tasks, with clearer improvements observed for relatively larger models.} Theoretically, we establish the iteration complexity of low-rank MSGD for finding an approximate stationary solution, and the iteration complexity of low-rank Muon for finding an approximate stochastic stationary solution under heavy-tailed noise. The code to reproduce our numerical experiments is available at https://github.com/dengzhanwang/Low-rank-Muon.

While foundation models have revolutionized fields such as natural language processing and computer vision, their potential in graph machine learning remains largely unexplored. One of the key challenges in designing graph foundation models (GFMs) is handling diverse node features that can vary across different graph datasets. While many works on GFMs have focused exclusively on text-attributed graphs, the problem of handling arbitrary features of other types in GFMs has not been fully addressed. However, this problem is not unique to the graph domain, as it also arises in the field of machine learning for tabular data. In this work, motivated by the recent success of tabular foundation models (TFMs) like TabPFNv2 and LimiX, we propose G2T-FM, a simple framework that allows tabular foundation models to be applied to graph node-level tasks. Specifically, G2T-FM augments the original node features with neighborhood feature aggregation, adds structural embeddings, and then applies a TFM to the constructed node representations. Even in the in-context learning setting, our model achieves strong results when combined with a strong TFM, outperforming both prior GFMs and well-tuned GNNs trained from scratch. Moreover, after finetuning, G2T-FM consistently surpasses well-tuned GNN baselines, often by a significant margin. In summary, our paper reveals the potential of a previously overlooked direction: utilizing tabular foundation models for graph machine learning tasks.

Depth estimation is a foundational component for 3D reconstruction in minimally invasive endoscopic surgeries. However, existing monocular depth estimation techniques often exhibit limited performance to the varying illumination and complex textures of the surgical environment. While applying foundation models offers a promising approach to enhance the depth estimation performance, the domain gap between the natural images used for pre-training and the target endoscopic images leads to significant semantic perception deficiencies. In this study, EndoUFM is introduced as an unsupervised monocular depth estimation framework that innovatively \underline{U}tilizes dual Foundation Models for Endoscopic images, thereby enhancing the depth estimation performance by leveraging the powerful pre-learned priors. The framework features a novel adaptive fine-tuning strategy that incorporates Random Vector Low-Rank Adaptation (RVLoRA) to enhance model adaptability, and a Residual block based on Depthwise Separable Convolution (Res-DSC) to improve the capture of fine-grained local features. A mask-guided smoothness loss is also introduced to enforce depth consistency within anatomical structures. Extensive experiments on the SCARED, Hamlyn, SERV-CT, and EndoNeRF datasets confirm that our method achieves state-of-the-art performance while maintaining an efficient model size. This work contributes to augmenting surgeons' spatial perception during minimally invasive procedures, thereby enhancing surgical precision and safety, with crucial implications for augmented reality and navigation systems. Our code is available at https://github.com/RealMindyY/EndoUFM.

The emergence of audio-visual foundation models underscores the importance of reliably assessing their multi-modal understanding. The VGGSound dataset is commonly used as a benchmark for evaluation audio-visual classification. However, our analysis identifies several limitations of VGGSound, including incomplete labelling, partially overlapping classes, and misaligned modalities. These lead to distorted evaluations of auditory and visual capabilities. To address these limitations, we introduce VGGSounder, a comprehensively re-annotated, multi-label test set that extends VGGSound and is specifically designed to evaluate audio-visual foundation models. VGGSounder features detailed modality annotations, enabling precise analyses of modality-specific performance. Furthermore, we reveal model limitations by analysing performance degradation when adding another input modality with our new modality confusion metric.

Industrial signal analysis is hindered by severe data heterogeneity, which we characterize as the M5 problem. Existing solutions rely on specialized models that lack robustness and scalability, while large-scale pre-training has rarely been investigated in this area. In this work, we derive a prioritized roadmap for the M5 problem and propose FISHER, a Foundation model for multi-modal Industrial Signal compreHEnsive Representation. To address the foremost multi-sampling-rate problem, FISHER utilizes a novel sub-band modeling approach that treats sampling rate increments as concatenated sub-band information, enabling the adaptive usage of full signal bandwidth without resampling. FISHER is pre-trained by teacher-student self-distillation over external audio and music data. We also establish the RMIS benchmark, comprising 19 datasets across four modalities. In the experiment, FISHER outperforms 24 state-of-the-art series encoders (up to 2B) with much smaller sizes (up to 16x), showcasing groundbreaking diagnostic accuracy and remarkable versatility. We further demonstrate that 1) seamless adaptation to variable sampling rates is the key to generalization 2) audio and music data provide better temporal variability, which is essential for pre-training. Both FISHER and RMIS are open-sourced.