Laboratory

Autonomous powder weighing is one of many bottlenecks in laboratory automation due to the complex, non-linear dynamics of heterogeneous materials. Robot chemists performing this task utilise standard tools shaped for the dexterity of human hands, whose fixed geometry sets the dynamics that the control policy needs to regulate. This work introduces a tool-policy co-design framework that concurrently optimises the morphology of a dispensing tool and its control policy for use by robots in chemistry laboratories, formulated as a bi-level optimisation that minimises dispensing error over a target distribution of powder flowabilities. The outer loop varies tool-design parameters such as tool depth, width and rim spike topology using Bayesian optimisation and hyperband, while an inner loop optimises a control policy for each candidate morphology. We also introduce a geometric similarity metric that warm-starts policy training from cached policies of structurally similar designs, exploring 28% more configurations under the same compute budget. The proposed framework is evaluated on a robotic powder weighing task across seven materials with distinct physical dynamics in a flowability-informed robot-material simulation framework. Experimental results demonstrate that our co-designed tool morphology reduces real-world weighing errors by 45% relative to a standard tool, including on previously unseen materials. These results demonstrate our method can adapt both the control policy and the physical tool to the dynamics of the target material, bringing a new paradigm for material manipulation to the field of laboratory automation.

Scientific tasks specify a desired capability, but realizing it often requires building a computational system tailored to the task---acquiring data, designing representations, training models, implementing tools, and deciding how they are used at inference. We present LabFactory, a framework in which an AI builder turns a scientific brief into an executable AI lab: a task-specific solver that integrates models, knowledge resources, tools, and a controller behind a fixed interface. The builder develops and packages the lab in a metered workspace; a separate host then executes the delivered artifact on held-out inputs, with reference labels kept outside the solver's input interface, and scores its outputs under the task's protocol. This makes the delivered system, rather than the builder's account of its progress, the object of evaluation. We document 28 selected constructions across seven scientific task categories---from molecular and genomic prediction to physiological signals, clinical decision support, and biomedical text---whose delivered labs exceeded their configured reference values on all 33 subtests under host-side execution. Ten contain predictive models fitted during construction; the others assemble retrieval systems, executable analysis environments, and tool-driven workflows around a fixed platform LLM. Together they show that an AI agent can carry a scientific brief all the way to a working lab that can still be invoked, inspected, and checked after construction ends.

Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of poorly soluble drugs, but identifying high-performing formulations remains experimentally intensive. We present Andromeda 2, an agentic system that reasons over structured in-house experimental evidence and invokes computational and experimental tools to design and execute successive formulation batches. Using a miniaturized automated laboratory at a matched budget, we benchmark it against Andromeda 1, a probabilistic optimization model deployed across dozens of live development projects, and a wet-lab design-of-experiments (DoE) campaign. For paclitaxel, Andromeda 2 achieved a 50% high-performance hit rate versus 17% for Andromeda 1 and 2% for DoE, and identified 12 formulations meeting all four target product profile (TPP) objectives versus 6 and 0, respectively. Median $AUC_{10-240}$ was 70.1, 12.0, and 3.5 mg$\cdot$min/mL, while maximum AUC was comparable between Andromeda 2 and Andromeda 1. A selected full-TPP formulation achieved an apparent effective paclitaxel loading of $19 \pm 5\%$ w/w at the first FaSSIF measurement, approximately 3.3-fold higher than the 5.7% w/w loading reported for a published paclitaxel S-SEDDS. A controlled ablation showed that access to structured in-house experimental evidence increased mean AUC by 34%.

Automating biological research requires general-purpose, reproducible robot systems that allow individual wet-lab researchers to delegate robot tasks without performing teleoperation or neural-network training. Vision-language-action policies have been proposed for general-purpose arms, but can lose performance when their operating environment changes. We therefore built WetRobo, a robot kit that can readily transfer between laboratories. It consists of one robot arm, laboratory equipment (an incubator, a reagent bottle with a cap, and a Petri dish), the existing code that moves the arm, teleoperation demonstrations of each task that we recorded, and a general AGENTS.md skill file. A biological experimentalist provides natural-language tasks without collecting local teleoperation training data or training a neural network. The coding agent observes the local laboratory and writes and executes programs, using external tools as needed for adaptation. We demonstrate use of WetRobo with OpenAI Codex (gpt-5.6-sol) on three successful tasks: lifting a Petri dish lid, removing a bottle cap, and opening the incubator door, all in real-world laboratories. The coding agent achieved the cap task in both laboratories, Lab X and Lab Y, whereas a VLA fine-tuned on Lab X demonstrations succeeded there but failed to transfer to Lab Y. These results point to a practical route for laboratory robotics: instead of training a policy for each laboratory, distribute a kit and let a coding agent adapt it in each laboratory. Code, demonstrations, and the evolved programs are available at https://github.com/tsudalab/WetRobo.

Teaching robotics relies on screen-based simulation, showing robot motion in an abstract coordinate frame rather than at real scale in the learner's own space, while access to physical hardware is limited by cost, safety, and scheduling constraints. We present MR-Robotics LAB, a mixed-reality (MR) platform that replays MATLAB-generated robot trajectories at real scale within the learner's physical environment. A browser-based service validates a MATLAB workspace file (.mat), normalizes units, and publishes a versioned JSON trajectory; a Unity application on a Meta Quest 3 then reproduces the authored joint configurations under position control and replays them at the declared frame rate within a physics-enabled scene that supports collision detection and end-effector grasping. A formative single-group evaluation with engineering students found that participants reported low setup effort (M = 4.67 on a 5-point scale) and perceived support for workspace understanding from multi-viewpoint inspection (M = 4.56), and 83% of participants affirmed their willingness to use the platform in an introductory robotics course. The evaluation instrument records only perceived outcomes, without counterbalancing or a learning measure, so no comparative advantage over desktop simulation is claimed. The contribution is a reusable simulation-to-MR trajectory pathway and design guidance for hardware-free robot visualization in engineering education.

Self-driving laboratories (SDLs) combine automated experimentation with adaptive decision-making to accelerate scientific discovery. Their operation nevertheless often depends on human specialists who translate scientific objectives into executable closed-loop campaigns. Specialists adjust them as data and operating conditions change. Here, we present La Agente 'Optima, an agentic framework that constructs and supervises Bayesian optimization campaigns across computational and experimental systems while maintaining a persistent optimization state. By separating large language model (LLM) reasoning from executed campaigns, 'Optima runs repetitive optimization loops consistently, returns control to the agent only when progress requires interpretation or campaign revision, and keeps every decision auditable. We evaluate 'Optima across ablation studies, five digital discovery tasks, and two physical platforms. Throughout, 'Optima maintained executable campaigns as both the scientific problem and execution environment evolved. In a closed-loop contact angle optimization campaign, 'Optima identified and corrected a mid-run measurement failure, bringing the contact angle from 71.4 to 67.8 degrees, just above the 64-66 degree range. From this result, 'Optima correctly inferred that the target was likely unattainable with the available reagents and recommended changing the formulation. In a five-day multi-objective flow-chemistry campaign, 'Optima increased the yield from 30% to 59% over 23 experiments. Despite substantial inference costs, it cost less and used substantially less starting material than a human-directed campaign, while selecting a more mass-efficient operating point. These results show that LLM-based agents can make rigorous, long-running optimization campaigns accessible to domain scientists without specialist setup, expanding the scope of SDLs.

Making science computable requires representations of both scientific knowledge and the physical world in which scientific claims are tested. A computable representation of the physical laboratory is established through typed research objects, capability-bound operations and a compositional workflow algebra. It provides the physical-world counterpart to machine-readable knowledge, expressing workflows as programs over evolving laboratory states with explicit dependencies, decisions, iteration and concurrency. The representation was implemented in a modular agentic robotic laboratory by binding formal operations to executable Function Skills. For diverse scientific intents, capability-relative workflows were generated, while stateful simulation propagated object transformations and verified operation preconditions and laboratory constraints before dispatch. The proposed representation and its engineering framework jointly establish a general computational interface between agent reasoning and capability-bound physical transformations, providing a foundation for end-to-end autonomous scientific discovery.

Language model pretraining has become almost synonymous with prohibitive cost, placing it out of reach for much of the academic and open-source communities. Although strong open-source efforts already exist, including open-weight models and open-source training recipes, a cost-efficient, hardware-accessible, and open-source pretraining recipe has long been missing. Even at a small scale, training Llama-3.2-3B costs over $1.5M, and reproducing SmolLM3-3B needs over $700K. In this report, we present an open pretraining recipe designed to lower this barrier. Using this recipe, we train a collection of Puro-2B models from scratch on up to 1.4 trillion tokens with FP8 precision on consumer-grade RTX 5090 GPUs. The models in the collection differ in token budgets and selected recipe variants. Our best model is trained at a compute cost of less than $6.9K and approaches Qwen2.5-1.5B performance under our evaluation protocol. This cost efficiency is enabled by a combination of approaches, including hardware selection, low-precision training, hyperball optimization, curriculum model averaging, and the data recipe. Beyond the recipe itself, we provide two additional results. First, across the Puro-2B collection, we derive a Puro Cost Scaling Law that relates training cost to average model performance; the fitted law suggests that about $4.4K, less than $5,090, is sufficient to reach the performance of Qwen2-1.5B. Second, as an end-to-end case study, we examine how pretraining data curricula shape downstream performance after post-training. Such controlled studies are enabled by having access to the full pretraining pipeline rather than model weights alone. We release the full training recipe for Puro-2B, including data, code, and model weights under Apache 2.0 at https://huggingface.co/collections/thu-pacman/puro-2b.

We introduce LabEvolver, a training-free framework that equips safe and grounded wet-lab agents with episodic memory from execution experience. LabEvolver couples a state-grounded inner trial loop for adaptive perception, online planning, and safety validation with an outer evolution loop that distills completed trajectories into reusable skill, strategy, and safety experience. On robotic solution-preparation tasks, LabEvolver demonstrates real-world feasibility, reducing pH-regulation completion time and safety-gate intercepts by 48.2% and 60.0%, respectively. On ALFWorld, it further improves cumulative success rate within 20 steps from 76.2% with ReAct to 91.4% over 500 continual tasks, showing generality beyond wet-lab settings. These results support learn-by-doing experience evolution as a feasible path toward closed-loop automated scientific discovery. The project page is available at https://andygao6186.github.io/LabEvolver/.

Biomedical laboratory robots must navigate to instruments before performing experimental procedures. Existing embodied navigation platforms are designed for household environments and treat a target as an object center or an arbitrary nearby position. This representation is inadequate for laboratory instruments, which must be approached from their operating side while maintaining safe clearance from surrounding equipment. We introduce BioVLN, a simulation platform for developing and evaluating visual-language navigation agents in biomedical laboratories. BioVLN represents each instrument with three regions: its physical body, a surrounding clearance region, and an operation area in front of the usable side. This model is applied consistently to scene generation, target placement, navigation evaluation, and safety analysis, so success depends on reaching a position from which the instrument can be accessed. BioVLN supports procedural scene generation and manually designed environments, producing 47 scenes and 1667 episodes. Standardized navigation and reinforcement-learning interfaces enable trajectory collection and policy training. Experiments show that geometric exploration reaches 74.4--87.5% success, while sampling multiple valid positions in the operation area improves success to 83.3--92.5% and reduces unsafe proximity.

Physical Unified Device Architecture (PUDA) is an AI-native hardware harness for self-driving laboratories (SDLs). Rather than building a human-centered graphical user interface (GUI) orchestration layer, PUDA creates a command-line runtime environment that lets agents observe, orient, decide, and act over experiments while hardware execution remains deterministic, atomic, and auditable. Headless by design, devices appear through discoverable command-line interfaces, JSON protocols are routed through a distributed messaging system, and command responses, data products, and reports are preserved as structured records. PUDA organizes protocols, runs, samples, measurements, and command logs into an AI-native data structure linked by run identifiers and timestamps, preserving provenance from submitted protocol through hardware response to resulting data products. PUDA separates scientific orchestration from physical operation and data telemetry: agents choose experiments, while PUDA executes validated commands and captures provenance-linked state, responses, and data. The contribution is not another optimizer, orchestrator, or recipe language. It is a practical execution and data environment for agentic SDLs; the broader physical AI implication is that PUDA provides an AI-native hardware harness for AI systems to interact with physical tools.

The deployment of embodied agents in self-driving laboratories could accelerate scientific discovery, yet their reliability is constrained by the irreversible and safety-critical nature of chemical experiments. Progress is further hindered by scarce failure data and the lack of fine-grained evaluation protocols. To address these challenges, we introduce LabRobFail, a failure-centric framework for learning and evaluating robotic failure analysis in chemical laboratories. LabRobFail-Sim injects controllable failures at the control, physics, and semantic levels, enabling the construction of LabRobFail-Data, which contains over 20,000 trajectories across 70+ task scenarios, five failure categories, and 11 fine-grained failure types. LabRobFail-Bench evaluates six capabilities spanning task understanding, failure detection, temporal localization, severity assessment, failure classification, and actionable correction. We further develop LabRobFail-VLM, a domain-specialized vision-language model that generates structured failure diagnoses and recovery instructions. On seen environments, it achieves 90.83% failure-detection accuracy and 77.21% temporal-localization accuracy, substantially outperforming general-purpose VLMs. When integrated as a real-time supervisor, it improves downstream task success rates by 4-16 percentage points, demonstrating the value of fine-grained failure understanding for closed-loop recovery and reliable laboratory autonomy. Our code and data are available at https://github.com/Su-ISE-2001/SciRobo

AI is evaluated through knowledge, reasoning and plan generation, yet scientific agency requires reliable physical action and adaptation to evidence. Here, we use a robotic chemistry laboratory as a physical-world testbed to make scientific agency measurable. Its 45 modular workstations exposed as machine-readable skills enabled 4,608 trials. Only 3.3% of trials produced expert-assessed executable workflows under laboratory constraints; even the best system achieved 28.1%. Long-horizon planning remained a challenge: only three executable workflows exceeded 30 operations, although the longest contained 44. Across five rounds, experimental feedback prompted local adjustments but no workflow-level replanning or analytical-method redesign. By making physical executability and evidence-driven replanning measurable, our study provides an evidence-based assessment of deployment readiness and a diagnostic framework to guide closed-loop improvements towards physically grounded autonomous research.

Autonomous biomedical laboratories increasingly rely on visual perception to recognize, localize, and manipulate transparent plasticware, yet high-quality real-world datasets for this setting remain limited. The scarcity of domain-relevant data is particularly restrictive in cluttered multi-object scenes, where mutual occlusion and view-dependent appearance changes remain challenging even for contemporary visual foundation models. Existing transparent-object datasets have advanced segmentation, depth, and pose estimation, but they usually do not evaluate the combined setting of multi-object clutter, occlusion, and calibrated multi-view capture that characterizes real laboratory manipulation scenes. To address this gap, we present TrainsBiolab, a real-world RGB-D dataset of cluttered transparent biomedical objects captured as calibrated multi-view sequences. TrainsBiolab contains 161,315 frames from 98 scenes and 1.03M instance annotations over 15 laboratory object types, including 6D poses, full and visible masks, depth, and per-frame camera calibration. The dataset is organized along three axes that reflect operational difficulty: object category, the total number of objects in a frame, and camera viewpoint. We further define dataset-centric benchmarks for segmentation, depth estimation and completion, and 6D pose estimation, and report a system-level robot manipulation evaluation enabled by the released annotations and calibrations. By focusing on repeated transparent instances, clutter, and multi-view laboratory capture, TrainsBiolab provides a resource for segmentation, depth estimation, 6D pose estimation, and multi-view reasoning in autonomous laboratory manipulation. Project page: https://dualtransparency.github.io/TransBiolab/.

Laboratory automation accelerates discovery, yet its adoption is constrained by the high cost, proprietary design, and limited remote supervisability of commercial liquid-handling systems. This work presents RAINBOT\textsuperscript{TM}, a low-cost, openly reproducible liquid-handling robot built by converting a consumer-grade Cartesian 3D printer (Elegoo Neptune 4 Max). The printer extruder is replaced by a precision single-channel pipette actuated through the printer's own G-code-driven X--Y--Z gantry, with plunger and tip-eject motions effected by two compact linear actuators under Python control. To make experiments transparent and remotely supervisable, a browser-based digital twin is implemented to synchronise bidirectionally with the physical platform, mirroring kinematics and pipetting states in real time and exposing remote monitoring, intervention, and an emergency stop from any web browser. As a proof of concept, RAINBOT\textsuperscript{TM} performed sequential exchanges of differently coloured aqueous solutions while an integrated colour sensor quantified the resulting mixtures; measured red, yellow, and blue (RYB) responses agreed with expected mixing behaviour to within a mean absolute error of two percentage points, validating correct execution and real-time tracking. Closing the loop, the platform is coupled to the CEID\textsuperscript{TM} (Cooperative Explorer for Inverse Design) framework, which recasts experimentation from iterative manual guessing into a goal-directed inverse-design search while keeping a human in the loop. The complete hardware costs under US$1300, which is roughly an order of magnitude below entry-level commercial handlers, thereby establishing an accessible physical--virtual framework for self-driving laboratory automation.

Self-driving laboratories increasingly rely on low-cost liquid handlers such as the Opentrons OT-2, which ship without the pressure-based aspiration monitoring of Hamilton or Tecan systems and are typically run open-loop. Two failure modes go undetected: protocols that are syntactically valid but violate assay-specific invariants (e.g., tip reuse between a PCR template and a no-template control), and physical execution failures (partial dispense, air bubbles, missing tips) at runtime. We present AEGIS, a two-layer guardian for both. Layer 1 pairs a curated machine-readable assay rule database with an LLM that reasons over OT-2 Python code, reaching an adjusted F1 of 0.97 on a 24-protocol benchmark across five assay families and beating rules-only and LLM-only ablations across five backends; a free open-weight model ties the best proprietary one, so no paid API is required. Layer 2 fits a PCA world model to YOLO-cropped four-frame pipette trajectories; under a leakage-free leave-one-plate-out evaluation it reaches average precision 0.89 and operating-point F1 0.71 (AUROC 0.80), a deployment-faithful number that matches the live demonstration, and we characterize the small-pipette (p20) resolution limit (F1 0.47). A live demonstration on a physical OT-2 (five replicates per condition) catches planted no-tip failures deterministically and partial dispense on coloured dyes, with an always-VLM self-vote gate lifting partial-dispense recall to 5/5; transparent water is a principled limit of any front-view-only monitor, which AEGIS surfaces as low-confidence VLM reasoning rather than a wrong verdict. Cascade triage holds VLM cost near $1.63 per plate versus$10.33 for an always-VLM baseline. AEGIS is open source and, to our knowledge, the first system to unify pre-flight assay-aware validation with runtime visual monitoring for an open-source liquid handler.

Agentic AI-for-Science can automate ideation, planning, and analysis, but final validation still depends on real experiments. A self-driving lab (SDL) can execute those experiments, yet the loop still has bottlenecks: the agent may spend too many rounds on low-value experiments, or each round may require a high-cost experiment. We target these two physical bottlenecks with one agent. First, a prior-aware agentic DOE loop uses domain knowledge and past results to propose feasible and informative next experiments, reducing trials-to-target. Second, a cost-aware surrogate agent predicts high-cost, high-resolution measurements from low-cost, low-resolution measurements. It chooses between a high- and a low-cost measurement based on the predicted uncertainty. We examine these directions in the biology and materials domains, respectively. Together, under a single agent, these components aim to accelerate the SDL loop by reducing both the number of loops and the cost per experiment.

In autonomous laboratories, AI agents suggest the next batch of experiments to do. However, planning and executing those tasks taking full advantage of the available resources is a completely different question. This can be challenging when dealing with real-world hardware constraints, especially so when there are multiple instruments with different capacities and throughputs. Here we demonstrate a 2-step method to address resource utilization for our autonomous platform for metal-organic framework synthesis. First, we use constraint programming to find optimal schedules. This finds schedules that minimizes the total time while still satisfying the limitations and capacities of the hardware. Secondly, we use a system of status dependencies for each task, which allows for the robust execution of the optimal schedules.

Scientific embodied agents are increasingly capable of carrying out laboratory procedures, but executing these procedures safely in dynamic laboratory environments remains challenging. Current safety approaches often overlook the intermediate step of transforming laboratory natural language, including safety rules, manuals, protocols, and standard operating procedures, into machine-checkable runtime constraints. We introduce LabGuard (Laboratory Guard), a language-to-execution safety suite that grounds natural-language laboratory rules into executable specifications and deploys them as runtime guards. LabGuard includes three core components: LabGuard-IR, which defines a typed executable representation; LabGuard-Bench, which provides 812 supervised annotations expanded from 203 seed laboratory rules; and LabGuard-Grounder, which maps natural-language laboratory rules into LabGuard-IR. The resulting IR instances are handled by the LabGuard Pipeline, which compiles them into runtime monitors and applies them at the controller boundary. Experiments show that LabGuard generalizes to unseen laboratory-rule sources, achieves 79.4 task-scope F1, and reduces unsafe events from 39.5% to 23.8% after monitor compilation. In LabUtopia, its runtime monitors integrate with ACT, keeping interventions below 0.5% while preserving task success.

Laboratory automation has made remarkable progress through robotic platforms and AI-driven scientific reasoning. However, many laboratory operations (e.g., solid--solid transfer) remain inherently dynamic and require real-time adaptation to different materials and experimental conditions. Such precision-critical manipulations are difficult to standardize, motivating the use of humanoid robots with dexterous hands. Despite this opportunity, no existing benchmark evaluates humanoid manipulation in precision-critical laboratory environments. We present Labimus, to our knowledge, the first benchmark for humanoid dexterous manipulation in organic chemistry laboratories. Labimus reconstructs over 30 functionally faithful assets from real organic chemistry workstations through real-to-sim modeling, collectively covering the core operations of routine organic chemistry experiments. The benchmark integrates articulated laboratory instruments, particle-based powder physics, and closed-loop instrument readouts, enabling a complete manipulation-to-measurement pipeline. It further defines six atomic operations and a seven-step solid-weighing workflow derived from real laboratory standard operating procedures. We introduce a precision-aware evaluation protocol designed to jointly measure task completion, experimental precision, and long-horizon execution. We benchmark three representative policies under procedural layouts and environmental perturbations. Results reveal a precision gap: policies that successfully complete laboratory tasks can still fail to satisfy the quantitative tolerances required by experimental protocols. Our benchmark exposes a fundamental disconnect between task completion and experimental validity, providing a new testbed for developing reliable humanoid robots for scientific laboratories.

Soil properties relevant to agricultural and environmental applications are conventionally measured using elaborate laboratory methods involving physical and chemical processing. While highly accurate, these conventional methods are costly and time-consuming. In contrast, optical spectroscopy paired with machine learning enables rapid and cost-effective predictions of multiple soil properties. However, spectroscopic modelling is often considered unreliable, as the predictive accuracy varies between soil properties and individual samples. To balance this trade-off between cost and reliability, we introduce reject-to-remeasure: an AI-based measurement framework that combines probabilistic modelling with uncertainty-guided rejection. In this framework, soil samples are first analysed using spectroscopy, after which predictions are rejected if their predictive uncertainty exceeds predefined quality constraints. Rejected samples are subsequently remeasured using conventional laboratory procedures. On a regional visible-near-infrared spectral soil library from Québec, we demonstrate that reject-to-remeasure with modern foundation models (TabPFNv2.5 and TabICLv2) can facilitate the integration of optical spectroscopy into routine laboratory workflows while meeting user-defined accuracy requirements and reducing measurement costs.

IVF pregnancy rates are routinely modeled using patient-level variables, while high-resolution laboratory environmental data remain underutilized. We show that this is a missed opportunity. Rather than relying on raw sensor averages, we engineer 55 context-aware temporal features, including rolling thermal stability, simultaneous temperature-humidity adherence, peak stress duration, and post-stress recovery speed, that capture the dynamics of incubator microenvironments. On 61 weeks of data from an Asian IVF clinic, these features reduce cross-validated prediction error to 1.27%, compared to 3-5% for raw averages. We then train a hierarchical Bayesian Beta regression model that shares environmental effects across an Asian and a Northern European clinic via partial pooling, while preserving site-specific baselines. On held-out data from the Northern European clinic, the model achieves R2 = 0.86 and a 64% error reduction for the 35-39 age group over a naive baseline, demonstrating that structured environmental monitoring contains clinically meaningful, transferable signal.

Biological experiment protocols are written in natural language, whereas automation systems rely on predefined control commands, creating a semantic gap that limits autonomous execution. Microplate-based automatic experiments are particularly challenging due to the need to simultaneously control well mapping, sample-reagent combinations, replicate placement, and parallel dispensing. This study proposes an agent-based protocol translation framework that converts natural-language microplate-based protocols into executable control commands for a robotic laboratory platform. A Parser Agent formalizes the natural-language protocol into a structured representation, and a rule-based mapping engine deterministically incorporates the operational constraints of the robotic laboratory platform to generate device-level control commands. A heterogeneous LLM Validation Agent verifies completeness, parameter accuracy, and execution order, and triggers a self-correction loop with structured feedback when errors are detected. A sweep involving 7 Parsers and 3 Validators on randomly selected ELISA protocols evaluates how model scale and Validator type affect translation accuracy and pass rates under cross-model verification. The accuracy-latency trade-off is further verified by comparing the rule-based mapping of the proposed framework with LLM end-to-end direct mapping. Finally, Bradford assay-based protein quantification using a microplate was demonstrated on a robotic laboratory platform, validating end-to-end autonomous execution from natural-language protocols to real-world experiments. The proposed framework provides a flexible approach to narrowing the semantic gap between natural-language protocols and microplate-based self-driving laboratories.

Self-driving laboratories (SDLs), where artificial intelligence proposes subsequent experiments and robotic systems execute them, are rapidly becoming the vanguard of materials discovery. A critical bottleneck, however, lies in seamlessly bridging diverse AI algorithms tailored for specific exploration goals with the heterogeneous robotic hardware found across different laboratories. Here, we present NIMO, an open-source software platform designed to dissolve this barrier through three core paradigms: a modular AI-robot decoupling mediated via simple CSV file exchange, a discrete candidate-pool architecture that seamlessly absorbs domain knowledge, and a unified Python interface pre-loaded with twelve distinct AI algorithms. In this Perspective, we review the operational principles of each algorithm alongside six diverse SDL implementations driven by NIMO, covering electrolyte discovery, organic synthesis, thin-film exploration, fuel-cell process informatics, coffee-ring phase exploration, and legacy liquid-handling automation. One of these also demonstrates NIMO's seamless interoperability with the IvoryOS orchestration framework. To democratize autonomous science, we also introduce a no-code desktop application that enables intuitive, human-in-the-loop exploration for non-programmers. NIMO is freely available at https://github.com/NIMS-DA/nimo, offering a versatile, plug-and-play foundation to accelerate autonomous materials exploration across diverse experimental landscapes.

Scientific laboratories increasingly rely on AI systems to reason about experiments, but the physical act of doing science remains largely outside their reach. AI can help read literature, generate hypotheses, and plan protocols, yet the execution of those protocols at the bench still requires a human operator. Vision-Language-Action (VLA) models provide one possible interface between written protocols and robot execution, but existing policies are trained mostly on household and tabletop demonstrations and rarely encounter the instruments, transparent liquids, or fixed protocol workflows found in scientific laboratories. Closing this gap requires both laboratory-specific supervision and a unified learning framework that can accommodate the diverse robot embodiments used to execute experimental protocols. We therefore identify data and embodiment as central bottlenecks alongside model design. To address the data side, we build RoboGenesis, a simulation-based workflow and data engine that composes configured laboratory workflows from atomic skills, validates and filters rollouts, and exports structured demonstrations across supported robot profiles. On the policy side, we present LabVLA, trained with a two-stage recipe: FAST action token pretraining first makes the Qwen3-VL-4B-Instruct backbone action aware before any continuous control is learned, and flow matching posttraining then attaches a DiT action expert under knowledge insulation. On the LabUtopia benchmark, LabVLA achieves the highest average success rate among all evaluated baselines under both in-distribution and out-of-distribution settings.

Wet-lab robots can improve the reproducibility, throughput, and safety of biomedical experiments, but scaling their learning requires customizable simulators for safe and reproducible task generation, open editable laboratory assets, and efficient pipelines that turn limited demonstrations into usable training data. We present Pipette, an embodied simulation platform, benchmark, and data-efficient augmentation framework for wet-lab robot learning. Pipette provides over 100 open-source and re-editable wet-lab assets through an extensible asset-building pipeline with built-in Tencent Hunyuan support for text- and image-conditioned 3D asset generation, and supports three robotic-arm embodiments through a unified simulation interface for task construction, data collection, augmentation, and evaluation. A key component of Pipette is its simulation-based data augmentation pipeline, which replays human demonstrations in simulation, applies lighting, camera, speed, and action perturbations, and filters generated episodes with automatic task success checks, rapidly expanding usable training data from limited manual demonstrations. We further introduce a 12-task wet-lab embodied benchmark covering sample handling, culture-ware manipulation, device operation, and precision placement. With only 30 demonstrations per task, ACT achieves 60.3% average success rate, while simulation augmentation improves SmolVLA from 40.4% to 71.8% and pi0 from 37.3% to 44.1%, validating the effectiveness of Pipette for data-efficient VLA training and evaluation. Pipette also supports natural-language-driven scene construction and task registration, lowering the barrier for non-expert users to define new wet-lab robotic tasks

Scientific discovery workflows rely heavily on lab notes, where researchers record observations, interpret uncertain results, and plan follow-up experiments. Unlike polished publications, lab notes preserve evolving scientific reasoning, tacit scientific knowledge, and author uncertainty, giving AI agents access to the process of science. However, most prior work on scientific text focuses on papers, protocols, or structured databases, leaving informal laboratory notes underexplored as inputs to AI agents for science. This gap matters because tacit knowledge in lab notes is not written as a clean set of instructions: validated observations, tentative judgments, and possible experimental next steps often appear in the same passage. If these signals are conflated, an AI agent may mistake uncertain scientific judgments for confirmed conclusions or executable actions. To this end, we present Notes2Skills, a two-stage framework for turning lab notebooks into verifiable skills for scientific AI agents while preserving the author's certainty. Across three wet-lab sessions and seven original downstream configurations, Notes2Skills is the only tested configuration that avoids both observed regime-level failures: over-acting on uncertain notes and missing firm directives. We show that certainty preservation is a key missing piece between lab notebooks and reliable agent skills, opening a path toward safer AI co-scientist systems.

Autonomous science is moving from demonstration to infrastructure. Large language model agents now plan experiments, and self-driving laboratories execute them. Yet every such system rebuilds the link between the reasoning agent and the physical instrument from scratch, against fragmented vendor SDKs and standards built for deterministic software clients rather than probabilistic, goal-directed agents. Recent agent-interoperability protocols clarify two of the three edges of an agentic ecosystem (Anthropic's Model Context Protocol (MCP) standardizes the agent-to-tool edge, and Google's Agent2Agent (A2A) the agent-to-agent edge), but neither models the agent-to-instrument edge, where operations are stateful, safety-critical, exclusively owned, physically embodied, and produce measurements with units, calibration, and uncertainty. We present the Lab Agent Protocol (LAP), a protocol design that fills this gap. LAP retains A2A's peer-to-peer, discovery-first, task-lifecycle structure and adds four physical-world primitives: (i) the InstrumentCard, a signed capability and physical-limit description; (ii) first-class reservation for exclusive instrument and sample locking; (iii) a safety-fence handshake with operator-confirmation tokens cryptographically bound to a specific task and its parameters, gating hazardous and irreversible operations; and (iv) a MeasurementResult schema that makes every result physically typed (QUDT/UCUM), calibration-anchored, uncertainty-bearing, and reproducible by construction. We specify roles, a six-layer architecture, the JSON-RPC method set, the task and safety state machines, the error model, and cross-laboratory federation, and walk a closed-loop autonomous campaign through the protocol end-to-end. LAP is transport-compatible with the A2A/MCP ecosystem and encapsulates rather than replaces existing device standards such as SiLA 2 and OPC-UA.

Educational virtual laboratories can make experimental training more scala-ble, adaptive, and accessible, especially when students have limited access to physical laboratory facilities. However, authoring new simulated laboratory procedures remains costly: educators must describe new equipment, define how instruments and materials interact, and specify valid procedural flows that can be executed or assessed inside the virtual environment. Large lan-guage models can assist in this authoring process by generating detailed ex-perimental procedures, but their output should not be treated as directly exe-cutable plans. They may omit necessary actions, arrange steps in the wrong order, or produce instructions that are logically incorrect or incompatible with the laboratory equipment. This paper presents a prototype framework for managing uncertainty in LLM-generated procedural knowledge for virtu-al laboratory planning. The framework aims to reduce procedural uncertainty by using structured domain representations and uncertain LLM-generated state-transition samples to extract candidate procedural rules, transform them into explicit and inspectable constraints, and use them to repair uncertain procedural steps. Although the motivating domain refers to educational vir-tual laboratories, the underlying problem is more general: managing uncer-tain procedural knowledge for action planning in structured interactive envi-ronments. We illustrate the approach in a virtual laboratory domain involving laboratory instruments, containers, tools, and material-transfer actions.

Automating science laboratories enables faster, safer, more accurate, and more reproducible execution of protocols, accelerating the discovery and testing of new materials, drugs, and more. However, setting up and running autonomous labs requires coordinating numerous instruments and robots, forcing scientists to write code, manage configuration files, and navigate complex software infrastructure. We present an AI agent architecture that integrates large language models with laboratory orchestration, enabling scientists to interactively create and monitor automated lab protocols using natural language. Integrated into the Experiment Orchestration System (EOS), the AI agent operates under an agentic loop with automated validation and error correction, and supports the complete experimental lifecycle: creating protocols, running and monitoring both protocols and closed-loop optimization campaigns, and analyzing results. A visual graph editor renders protocols as interactive node-based diagrams synchronized with the AI agent's protocol representation, enabling seamless alternation between AI-assisted and manual protocol construction. Evaluated on three simulated automated labs spanning chemistry, biology, and materials science, the AI agent achieves a 97% first-attempt protocol generation success rate and an order of magnitude reduction in required interface actions.

Self-driving laboratories (SDLs) are attracting increasing attention as a means of accelerating scientific discovery; however, developing SDL software remains technically demanding. To improve accessibility, orchestration software frameworks have been proposed to coordinate SDL components, but many existing frameworks are primarily designed for human interaction and lack standardized interfaces for direct integration with AI agents. In this work, we propose an SDL software architecture based on the Model Context Protocol (MCP), in which all SDL functionalities are exposed through MCP servers. Following this design principle, we introduce NIMO Controller, an MCP-based SDL orchestrator that integrates the experimental planning software NIMO. It provides a visual programming interface automatically generated through MCP-based tool discovery, allowing human users to design experimental workflows without writing code. The same MCP backend is also accessible to AI agents, providing a unified interface through which both human users and AI agents can interact with SDL components. AI agents can invoke MCP tools directly or generate NIMO workflows from natural language instructions. We evaluated the agentic workflow generation performance of various LLMs and conducted a user study using a color-matching SDL.

Biological laboratory automation can reduce repetitive manual work and improve reproducibility, but reliable embodied execution in wet-lab environments remains challenging. Protocols are often unstructured, labware is frequently transparent or reflective, and multi-step procedures require state-aware execution beyond one-shot instruction following. Existing robotic systems often rely on costly hardware, fixed workflows, dedicated instruments, or robotics-oriented interfaces. Here, we introduce BioProVLA-Agent, an affordable, protocol-driven, vision-enhanced embodied multi-agent system enabled by Vision-Language-Action (VLA) models for biological manipulation. The system uses protocols as the task interface and integrates protocol parsing, visual state verification, and embodied execution in a closed-loop workflow. A Tailored LLM Protocol Agent converts protocols into verifiable subtasks; a VLM-RAG Verification Agent assesses readiness and completion using observations, robot states, retrieved knowledge, and success/failure examples; and a VLA Embodied Agent executes verified subtasks through a lightweight policy. To improve robustness under wet-lab visual perturbations, we develop AugSmolVLA, an online augmentation strategy targeting transparent labware, reflections, illumination shifts, and overexposure. We evaluate the system on a hierarchical benchmark covering 15 atomic tasks, 6 composite workflows, and 3 bimanual tasks, including tube loading, sorting, waste disposal, cap twisting, and liquid pouring. Across normal and high-exposure settings, AugSmolVLA improves execution stability over ACT, X-VLA, and the original SmolVLA, especially for precise placement, transparent-object manipulation, composite workflows, and visually degraded scenes. These results suggest a practical route toward accessible, protocol-centered, and verification-capable embodied AI for biological manipulation.

To unleash the full potential of AI for Science, we must untether the agents from a purely digital environment. The agent's ability to control and explore in real-world labs is essential because the physical lab remains foundational to scientific discovery. While some tasks can be performed on a computer (e.g., data analysis, running simulated experiments), Eureka moments could occur at any time while operating lab instruments (e.g., when a scientist notices unexpected clues, intuition may prompt a real-time course change). Although autonomous labs are on the rise, which expose programmable APIs to control scientific instruments via software, bridging the gap between increasingly powerful AI agents and automated lab equipment requires innovation that draws insights from computer systems. We propose a new paradigm called ``Experiment-as-Code (EaC) Labs,'' where a core concept is to encode experiments as declarative configurations that can be compiled down to device-level APIs. AI agents come up with hypotheses and experiments, written as an ensemble of declarative configurations. The systems layer performs program analysis, safety checks, resource assignment, and job orchestration. Finally, programmatic experimentation occurs via actuating the device APIs. This is a general stack that is science-, lab-, and instrument-independent, representing a novel synthesis across the physical, systems, and intelligence layers to unleash the next breakthrough in AI for Science.

Automated laboratories hold the promise of accelerating scientific discovery, yet their deployment is bottlenecked by the difficulty of designing safe and executable environments. While simulator-based design offers scalability, existing 3D scene generation methods are primarily tailored for household settings, optimizing for visual plausibility while neglecting the protocol grounding and layout-level safety constraints essential for scientific experimentation. We present LabBuilder, an end-to-end system that generates and verifies 3D laboratory layouts from concise textual specifications. It operates through three tightly coupled components: LabForge first curates a meta-dataset of annotated assets and chemical knowledge, translating natural language specifications into structured protocols; building on these protocols, LabGen synthesizes laboratory layouts via an iterative, constraint-aware optimization strategy; finally, LabTouchstone evaluates the resulting layouts as a unified benchmark. Extensive experiments demonstrate that LabBuilder significantly outperforms existing state-of-the-art methods, producing laboratory environments that are realistic and valid under modeled geometric, chemical-safety, and navigation constraints.

Timely detection of concerning events is an important problem in clinical practice. In this paper, we consider the problem of conditional anomaly detection that aims to identify data instances with an unusual response, such as the omission of an important lab test. We develop a new non-parametric approach for conditional anomaly detection based on the soft harmonic solution, with which we estimate the confidence of the label to detect anomalous mislabeling. We further regularize the solution to avoid the detection of isolated examples and examples on the boundary of the distribution support. We demonstrate the efficacy of the proposed method in detecting unusual labels on a real-world electronic health record dataset and compare it to several baseline approaches.

Field robotics research in maritime and space domains is constrained by a persistent gap between low-cost, low-fidelity simulation and costly offshore experimentation. Instrumented water tanks partially bridge this gap but often provide limited sensing, restricted experimental capabilities, and weak integration with simulation tools. To address these limitations, we present Marinarium, a modular, standalone experimental facility that provides a cost-effective intermediate testbed between simulation and field deployment. Marinarium combines a fully instrumented underwater and aerial operational volume with motion capture (MoCap), a retractable roof enabling both sheltered and open-air operation, a digital twin implemented in SMaRCSim, and direct integration with a planar space robotics laboratory, enabling both maritime and underwater space-analog experimentation. We present the design rationale of the facility and validate its capabilities through four representative studies in field robotics: (i) data-driven system identification of underwater vehicle dynamics; (ii) heterogeneous multi-domain robotic rendezvous; (iii) sim-to-real transfer for underwater robotics using learned dynamics residuals; and (iv) cross-domain validation of spacecraft autonomy using underwater surrogates. Together, these studies demonstrate that Marinarium enables reproducible, instrumented experimentation across multiple field robotics challenges that would otherwise require costly offshore deployments or be impractical to investigate using simulation alone.

Aiming to match pedestrian images captured under varying lighting conditions, visible-infrared person re-identification (VI-ReID) has drawn intensive research attention and achieved promising results. However, in real-world surveillance contexts, data is distributed across multiple devices/entities, raising privacy and ownership concerns that make existing centralized training impractical for VI-ReID. To tackle these challenges, we propose L2RW, a benchmark that brings VI-ReID closer to real-world applications. The rationale of L2RW is that integrating decentralized training into VI-ReID can address privacy concerns in scenarios with limited data-sharing regulation. Specifically, we design protocols and corresponding algorithms for different privacy sensitivity levels. In our new benchmark, we ensure the model training is done in the conditions that: 1) data from each camera remains completely isolated, or 2) different data entities (e.g., data controllers of a certain region) can selectively share the data. In this way, we simulate scenarios with strict privacy constraints which is closer to real-world conditions. Intensive experiments with various server-side federated algorithms are conducted, showing the feasibility of decentralized VI-ReID training. Notably, when evaluated in unseen domains (i.e., new data entities), our L2RW, trained with isolated data (privacy-preserved), achieves performance comparable to SOTAs trained with shared data (privacy-unrestricted). We hope this work offers a novel research entry for deploying VI-ReID that fits real-world scenarios and can benefit the community.