Multi-Agent LLM Systems

The aerodynamic design of turbomachinery is a complex and tightly coupled multi-stage process involving geometry generation, performance prediction, optimization, and high-fidelity physical validation. Existing intelligent design approaches typically focus on individual stages or rely on loosely coupled pipelines, making fully autonomous end-to-end design challenging. To address this issue, this study proposes TurboAgent, a large language model (LLM)-driven autonomous multi-agent framework for turbomachinery aerodynamic design and optimization. The LLM serves as the core for task planning and coordination, while specialized agents handle generative design, rapid performance prediction, multi-objective optimization, and physics-based validation. The framework transforms traditional trial-and-error design into a data-driven collaborative workflow, with high-fidelity simulations retained for final verification. A transonic single-rotor compressor is used for validation. The results show strong agreement between target performance, generated designs, and CFD simulations. The coefficients of determination for mass flow rate, total pressure ratio, and isentropic efficiency all exceed 0.91, with normalized RMSE values below 8%. The optimization agent further improves isentropic efficiency by 1.61% and total pressure ratio by 3.02%. The complete workflow can be executed within approximately 30 minutes under parallel computing. These results demonstrate that TurboAgent enables an autonomous closed-loop design process from natural language requirements to final design generation, providing an efficient and scalable paradigm for turbomachinery aerodynamic design.

Sequential diagnosis requires balancing diagnostic accuracy against resource costs through iterative information gathering. Existing Large Language Model (LLM) approaches exhibit a critical knowledge-reasoning gap: despite encoding extensive medical knowledge, they struggle to reason systematically under cost constraints, often resorting to excessive testing. We propose GraphDx, a knowledge-enhanced framework with two core innovations. First, we design an automated pipeline that leverages LLMs to construct Medical Diagnosis Knowledge Graphs (MDKGs) with quantized typicality, action-centric topology, and dual-objective attributes for both diagnostic relevance and cost-sensitivity. Second, we introduce three collaborative agents (Perception, Reasoning, and Decision) where the Perception and Decision Agents handle language understanding and generation, while the Reasoning Agent performs deterministic evidence scoring and cost-aware planning on the MDKG. Experiments on MedQA and MIMIC-IV across three LLM backbones (DeepSeek-V3, Kimi-k2, Llama-3.3) show that GraphDx improves diagnostic success rates from 50--68% to 79--93% while reducing test costs by 20--54%, providing a robust, economical, and interpretable solution for automated clinical diagnosis.

Large language models show potential for scalable mental-health support by simulating Cognitive Behavioral Therapy (CBT) counselors. However, existing methods often rely on static cognitive profiles and omniscient single-agent simulation, failing to capture the dynamic, information-asymmetric nature of real therapy. We introduce CCD-CBT, a multi-agent framework that shifts CBT simulation along two axes: 1) from a static to a dynamically reconstructed Cognitive Conceptualization Diagram (CCD), updated by a dedicated Control Agent, and 2) from omniscient to information-asymmetric interaction, where the Therapist Agent must reason from inferred client states. We release CCDCHAT, a synthetic multi-turn CBT dataset generated under this framework. Evaluations with clinical scales and expert therapists show that models fine-tuned on CCDCHAT outperform strong baselines in both counseling fidelity and positive-affect enhancement, with ablations confirming the necessity of dynamic CCD guidance and asymmetric agent design. Our work offers a new paradigm for building theory-grounded, clinically-plausible conversational agents.

We present Qualixar OS, the first application-layer operating system for universal AI agent orchestration. Unlike kernel-level approaches (AIOS) or single-framework tools (AutoGen, CrewAI), Qualixar OS provides a complete runtime for heterogeneous multi-agent systems spanning 10 LLM providers, 8+ agent frameworks, and 7 transports. We contribute: (1) execution semantics for 12 multi-agent topologies including grid, forest, mesh, and maker patterns; (2) Forge, an LLM-driven team design engine with historical strategy memory; (3) three-layer model routing combining Q-learning, five strategies, and Bayesian POMDP with dynamic multi-provider discovery; (4) a consensus-based judge pipeline with Goodhart detection, JSD drift monitoring, and alignment trilemma navigation; (5) four-layer content attribution with HMAC signing and steganographic watermarks; (6) universal compatibility via the Claw Bridge supporting MCP and A2A protocols with a 25-command Universal Command Protocol; (7) a 24-tab production dashboard with visual workflow builder and skill marketplace. Qualixar OS is validated by 2,821 test cases across 217 event types and 8 quality modules. On a custom 20-task evaluation suite, the system achieves 100% accuracy at a mean cost of $0.000039 per task. Source-available under the Elastic License 2.0.

The rapid growth of scientific literature has made it increasingly difficult for researchers to efficiently discover, evaluate, and synthesize relevant work. Recent advances in multi-agent large language models (LLMs) have demonstrated strong potential for understanding user intent and are being trained to utilize various tools. In this paper, we introduce Paper Circle, a multi-agent research discovery and analysis system designed to reduce the effort required to find, assess, organize, and understand academic literature. The system comprises two complementary pipelines: (1) a Discovery Pipeline that integrates offline and online retrieval from multiple sources, multi-criteria scoring, diversity-aware ranking, and structured outputs; and (2) an Analysis Pipeline that transforms individual papers into structured knowledge graphs with typed nodes such as concepts, methods, experiments, and figures, enabling graph-aware question answering and coverage verification. Both pipelines are implemented within a coder LLM-based multi-agent orchestration framework and produce fully reproducible, synchronized outputs including JSON, CSV, BibTeX, Markdown, and HTML at each agent step. This paper describes the system architecture, agent roles, retrieval and scoring methods, knowledge graph schema, and evaluation interfaces that together form the Paper Circle research workflow. We benchmark Paper Circle on both paper retrieval and paper review generation, reporting hit rate, MRR, and Recall at K. Results show consistent improvements with stronger agent models. We have publicly released the website at https://papercircle.vercel.app/ and the code at https://github.com/MAXNORM8650/papercircle.

Large language model (LLM) agents are increasingly acting as human delegates in multi-agent environments, where a representative agent integrates diverse peer perspectives to make a final decision. Drawing inspiration from social psychology, we investigate how the reliability of this representative agent is undermined by the social context of its network. We define four key phenomena-social conformity, perceived expertise, dominant speaker effect, and rhetorical persuasion-and systematically manipulate the number of adversaries, relative intelligence, argument length, and argumentative styles. Our experiments demonstrate that the representative agent's accuracy consistently declines as social pressure increases: larger adversarial groups, more capable peers, and longer arguments all lead to significant performance degradation. Furthermore, rhetorical strategies emphasizing credibility or logic can further sway the agent's judgment, depending on the context. These findings reveal that multi-agent systems are sensitive not only to individual reasoning but also to the social dynamics of their configuration, highlighting critical vulnerabilities in AI delegates that mirror the psychological biases observed in human group decision-making.

Network Intrusion Detection Systems (NIDS) face important limitations. Signature-based methods are effective for known attack patterns, but they struggle to detect zero-day attacks and often miss modified variants of previously known attacks, while many machine learning approaches offer limited interpretability. These challenges become even more severe in IoT environments because of resource constraints and heterogeneous protocols. To address these issues, we propose MA-IDS, a Multi-Agent Intrusion Detection System that combines Large Language Models (LLMs) with Retrieval Augmented Generation (RAG) for reasoning-driven intrusion detection. The proposed framework grounds LLM reasoning through a persistent, self-building Experience Library. Two specialized agents collaborate through a FAISS-based vector database: a Traffic Classification Agent that retrieves past error rules before each inference, and an Error Analysis Agent that converts misclassifications into human-readable detection rules stored for future retrieval, enabling continual learning through external knowledge accumulation, without modifying the underlying language model. Evaluated on NF-BoT-IoT and NF-ToN-IoT benchmark datasets, MA-IDS achieves Macro F1-Scores of 89.75% and 85.22%, improving over zero-shot baselines of 17% and 4.96% by more than 72 and 80 percentage points. These results are competitive with SVM while providing rule-level explanations for every classification decision, demonstrating that retrieval-augmented reasoning offers a principled path toward explainable, self-improving intrusion detection for IoT networks.

Multi-objective retrosynthesis planning is a critical chemistry task requiring dynamic balancing of quality, safety, and cost objectives. Language model-based multi-agent systems (MAS) offer a promising approach for this task: leveraging interactions of specialized agents to incorporate multiple objectives into retrosynthesis planning. We present MMORF, a framework for constructing MAS for multi-objective retrosynthesis planning. MMORF features modular agentic components, which can be flexibly combined and configured into different systems, enabling principled evaluation and comparison of different system designs. Using MMORF, we construct two representative MAS: MASIL and RFAS. On a newly curated benchmark consisting of 218 multi-objective retrosynthesis planning tasks, MASIL achieves strong safety and cost metrics on soft-constraint tasks, frequently Pareto-dominating baseline routes, while RFAS achieves a 48.6% success rate on hard-constraint tasks, outperforming state-of-the-art baselines. Together, these results show the effectiveness of MMORF as a foundational framework for exploring MAS for multi-objective retrosynthesis planning. Code and data are available at https://github.com/ninglab/MMORF.

This paper presents OpenCLAW-P2P v7.0, a comprehensive evolution of the decentralized collective-intelligence platform in which autonomous AI agents publish, peer-review, score, and iteratively improve scientific research papers without any human gatekeeper. Building on the v6.0 foundations -- multi-layer persistence, live reference verification, multi-LLM granular scoring, calibrated deception detection, the Silicon Chess-Grid FSM, and the AETHER containerized inference engine -- this release introduces mathematical corrections to the theoretical framework, ensuring dimensional consistency, proper range constraints, and unambiguous notation throughout. Additionally, this edition documents significant ecosystem expansions including the CAJAL family of open-source language models (4B and 9B parameters) fine-tuned for scientific paper generation. The four major subsystems introduced in v6.0 are retained: (i) a Multi-Layer Paper Persistence Architecture with four storage tiers ensuring zero paper loss; (ii) a Multi-Layer Retrieval Cascade reducing latency from >3s to <50ms; (iii) a Live Reference Verification system detecting fabricated citations with >85% accuracy; and (iv) a Scientific API Proxy providing access to seven public scientific databases. Mathematical corrections in v7.0 include: corrected fixed-point condition in the Sufficient Reason theorem; dimensionally consistent progress-rate indicator; fully specified reputation update formula incorporating quality terms q0 and q-bar; clarified attention-logit bound in the AETHER pruning theorem; explicit range documentation for the calibration mapping; non-negativity guarantee for the depth score; discrete-time notation for the PD Governor; and explicit parameter definitions for the HSR weight formula.

Service system performance depends on how participants respond to design choices, but modeling these responses is hard due to the complexity of human behavior. We introduce an LLM-powered multi-agent simulation (LLM-MAS) framework for optimizing service operations. We pose the problem as stochastic optimization with decision-dependent uncertainty: design choices are embedded in prompts and shape the distribution of outcomes from interacting LLM-powered agents. By embedding key numerical information in prompts and extracting it from LLM-generated text, we model this uncertainty as a controlled Markov chain. We develop an on-trajectory learning algorithm that, on a single simulation run, simultaneously constructs zeroth-order gradient estimates and updates design parameters to optimize steady-state performance. We also incorporate variance reduction techniques. In a sustainable supply chain application, our method outperforms benchmarks, including blackbox optimization and using LLMs as numerical solvers or as role-playing system designers. A case study on optimal contest design with real behavioral data shows that LLM-MAS is both as a cost-effective evaluator of known designs and an exploratory tool that can uncover strong designs overlooked by traditional approaches.

As Large Language Models (LLMs) are increasingly deployed in complex applications, their vulnerability to adversarial attacks raises urgent safety concerns, especially those evolving over multi-round interactions. Existing defenses are largely reactive and struggle to adapt as adversaries refine strategies across rounds. In this work, we propose CoopGuard , a stateful multi-round LLM defense framework based on cooperative agents that maintains and updates an internal defense state to counter evolving attacks. It employs three specialized agents (Deferring Agent, Tempting Agent, and Forensic Agent) for complementary round-level strategies, coordinated by System Agent, which conditions decisions on the evolving defense state (interaction history) and orchestrates agents over time. To evaluate evolving threats, we introduce the EMRA benchmark with 5,200 adversarial samples across 8 attack types, simulating progressively LLM multi-round attacks. Experiments show that CoopGuard reduces attack success rate by 78.9% over state-of-the-art defenses, while improving deceptive rate by 186% and reducing attack efficiency by 167.9%, offering a more comprehensive assessment of multi-round defense. These results demonstrate that CoopGuard provides robust protection for LLMs in multi-round adversarial scenarios.

We develop a unified treatment of credit assignment for RL training in multi-agent LLM systems. We show that observed reward alone cannot distinguish an agent that determines it from one that never affects it, and that standard shared-reward training performs exact gradient ascent on each agent's private utility rather than system performance. Moreover, we prove no single scalar per agent can consistently account for joint performance once agents interact. We thus develop the unique background-dependent notion of marginal contribution satisfying natural consistency requirements. From it we derive gradient-correct marginal contribution training signals, identify them from filtered feedback, and optimally allocate a budget of exact counterfactual evaluations against learned-signal error. Instantiated in GRPO, our signal improves routed GSM8K accuracy over winner-take-all training at no extra generation cost.

As Large Language Model (LLM) based Multi-Agent Systems (MAS) evolve from experimental pilots to complex, persistent ecosystems, the limitations of direct agent-to-agent communication have become increasingly apparent. Current architectures suffer from fragmented context, stochastic hallucinations, rigid security boundaries, and inefficient topology management. This paper introduces Cognitive Fabric Nodes (CFN), a novel middleware layer that creates an omnipresent "Cognitive Fabric" between agents. Unlike traditional message queues or service meshes, CFNs are not merely pass-through mechanisms; they are active, intelligent intermediaries. Central to this architecture is the elevation of Memory from simple storage to an active functional substrate that informs four other critical capabilities: Topology Selection, Semantic Grounding, Security Policy Enforcement, and Prompt Transformation. We propose that each of these functions be governed by learning modules utilizing Reinforcement Learning (RL) and optimization algorithms to improve system performance dynamically. By intercepting, analyzing, and rewriting inter-agent communication, the Cognitive Fabric ensures that individual agents remain lightweight while the ecosystem achieves coherence, safety, and semantic alignment. We evaluate the effectiveness of the CFN on the HotPotQA and MuSiQue datasets in a multi-agent environment and demonstrate that the CFN improves performance by more than 10% on both datasets over direct agent to agent communication.

Autonomous network management in Open Radio Access Networks requires intelligent decision making across conflicting objectives, yet existing LLM based multi agent systems employ homogeneous strategies and lack systematic predeployment validation. We introduce a persona driven multi agent framework where configurable behavioral personas structured specifications encoding optimization priorities, risk tolerance, and decision making style influence five specialized agents (planning, coordination, resource allocation, code generation, analysis). To enable rigorous validation, we develop a three dimensional evaluation framework grounded in decision theory, measuring normative compliance (optimality adherence), prescriptive alignment (behavioral guideline consistency), and behavioral dynamics (emergent system properties). We evaluate 486 persona configurations across two ORAN optimization challenges (energy efficient resource allocation and network load balancing). Results demonstrate that persona agent alignment significantly impacts both individual performance (14.3 percent) and emergent multi agent coordination, with retrieval architecture (GraphRAG vs. RAG) fundamentally constraining customization effectiveness. Single agent persona modifications propagate system wide through cascading effects, with certain combinations exhibiting detectable fundamental incompatibilities. Our framework provides systematic validation mechanisms for deploying LLM based automation in mission critical telecommunications infrastructure.

Given a user's complex information need, a multi-agent Deep Research system iteratively plans, retrieves, and synthesizes evidence across hundreds of documents to produce a high-quality answer. In one possible architecture, an orchestrator agent coordinates the process, while parallel worker agents execute tasks. Current Deep Research systems, however, often rely on hand-engineered prompts and static architectures, making improvement brittle, expensive, and time-consuming. We therefore explore various multi-agent optimization methods to show that enabling agents to self-play and explore different prompt combinations can produce high-quality Deep Research systems that match or outperform expert-crafted prompts.

Recent agentic search systems have made substantial progress by emphasising deep, multi-step reasoning. However, this focus often overlooks the challenges of wide-scale information synthesis, where agents must aggregate large volumes of heterogeneous evidence across many sources. As a result, most existing large language model agent systems face severe limitations in data-intensive settings, including context saturation, cascading error propagation, and high end-to-end latency. To address these challenges, we present \framework, a hierarchical framework based on principle of near-decomposability, containing a strategic Host, multiple Managers and parallel Workers. By leveraging aggregation and reflection mechanisms at the Manager layer, our framework enforces strict context isolation to prevent saturation and error propagation. Simultaneously, the parallelism in worker layer accelerates the speed of overall task execution, mitigating the significant latency. Our evaluation on two complementary benchmarks demonstrates both efficiency ($3-5 \times$ speed-up) and effectiveness, achieving a $8.4\%$ success rate on WideSearch-en and $52.9\%$ accuracy on BrowseComp-zh. The code is released at https://github.com/agent-on-the-fly/InfoSeeker

Recent work reports strong performance from multi-agent LLM systems (MAS), but these gains are often confounded by increased test-time computation. When computation is normalized, single-agent systems (SAS) can match or outperform MAS, yet the theoretical basis and evaluation methodology behind this comparison remain unclear. We present an information-theoretic argument, grounded in the Data Processing Inequality, suggesting that under a fixed reasoning-token budget and with perfect context utilization, single-agent systems are more information-efficient. This perspective further predicts that multi-agent systems become competitive when a single agent's effective context utilization is degraded, or when more compute is expended. We test these predictions in a controlled empirical study across three model families (Qwen3, DeepSeek-R1-Distill-Llama, and Gemini 2.5), comparing SAS with multiple MAS architectures under matched budgets. We find that SAS consistently match or outperform MAS on multi-hop reasoning tasks when reasoning tokens are held constant. Beyond aggregate performance, we conduct a detailed diagnostic analysis of system behavior and evaluation methodology. We identify significant artifacts in API-based budget control (particularly in Gemini 2.5) and in standard benchmarks, both of which can inflate apparent gains from MAS. Overall, our results suggest that, for multi-hop reasoning tasks, many reported advantages of multi-agent systems are better explained by unaccounted computation and context effects rather than inherent architectural benefits, and highlight the importance of understanding and explicitly controlling the trade-offs between compute, context, and coordination in agentic systems.

Embedding LLM-driven agents into environmental FAIR data management is compelling - they can externalize operational knowledge and scale curation across heterogeneous data and evolving conventions. However, replacing deterministic components with probabilistic workflows changes the failure mode: LLM pipelines may generate plausible but incorrect outputs that pass superficial checks and propagate into irreversible actions such as DOI minting and public release. We introduce EnviSmart, a production data management system deployed on campus-wide storage infrastructure for environmental research. EnviSmart treats reliability as an architectural property through two mechanisms: a three-track knowledge architecture that externalizes behaviors (governance constraints), domain knowledge (retrievable context), and skills (tool-using procedures) as persistent, interlocking artifacts; and a role-separated multi-agent design where deterministic validators and audited handoffs restore fail-stop semantics at trust boundaries before irreversible steps. We compare two production deployments. The University's GIS Center Ecological Archive (849 curated datasets) serves as a single-agent baseline. SF2Bench, a compound flooding benchmark comprising 2,452 monitoring stations and 8,557 published files spanning 39 years, validates the multi-agent workflow. The multi-agent approach improved both efficiency - completed by a single operator in two days with repeated artifact reuse across deployments - and reliability: audited handoffs detected and blocked a coordinate transformation error affecting all 2,452 stations before publication. A representative incident (ISS-004) demonstrated boundary-based containment with 10-minute detection latency, zero user exposure, and 80-minute resolution. This paper has been accepted at PEARC 2026.

Traditional social science research often requires designing complex experiments across vast methodological spaces and depends on real human participants, making it labor-intensive, costly, and difficult to scale. Here we present S-Researcher, an LLM-agent-based platform that assists researchers in conducting social science research more efficiently and at greater scale by "siliconizing" both the research process and the participant pool. To build S-Researcher, we first develop YuLan-OneSim, a large-scale social simulation system designed around three core requirements: generality via auto-programming from natural language to executable scenarios, scalability via a distributed architecture supporting up to 100,000 concurrent agents, and reliability via feedback-driven LLM fine-tuning. Leveraging this system, S-Researcher supports researchers in designing social experiments, simulating human behavior with LLM agents, analyzing results, and generating reports, forming a complete human-AI collaborative research loop in which researchers retain oversight and intervention at every stage. We operationalize LLM simulation research paradigms into three canonical reasoning modes (induction, deduction, and abduction) and validate S-Researcher through systematic case studies: inductive reproduction of cultural dynamics consistent with Axelrod's theory, deductive testing of competing hypotheses on teacher attention validated against survey data, and abductive identification of a cooperation mechanism in public goods games confirmed by human experiments. S-Researcher establishes a new human--AI collaborative paradigm for social science, in which computational simulation augments human researchers to accelerate discovery across the full spectrum of social inquiry.

With the rise of personalized, persistent LLM agent frameworks such as OpenClaw, human-centered agentic social networks in which teams of collaborative AI agents serve individual users in a social network across multiple domains are becoming a reality. This setting creates novel privacy challenges: agents must coordinate across domain boundaries, mediate between humans, and interact with other users' agents, all while protecting sensitive personal information. While prior work has evaluated multi-agent coordination and privacy preservation, the dynamics and privacy risks of human-centered agentic social networks remain unexplored. To this end, we introduce AgentSocialBench, the first benchmark to systematically evaluate privacy risk in this setting, comprising scenarios across seven categories spanning dyadic and multi-party interactions, grounded in realistic user profiles with hierarchical sensitivity labels and directed social graphs. Our experiments reveal that privacy in agentic social networks is fundamentally harder than in single-agent settings: (1) cross-domain and cross-user coordination creates persistent leakage pressure even when agents are explicitly instructed to protect information, (2) privacy instructions that teach agents how to abstract sensitive information paradoxically cause them to discuss it more (we call it abstraction paradox). These findings underscore that current LLM agents lack robust mechanisms for privacy preservation in human-centered agentic social networks, and that new approaches beyond prompt engineering are needed to make agent-mediated social coordination safe for real-world deployment.

Scientific discovery is slowed by fragmented literature that requires excessive human effort to gather, analyze, and understand. AI tools, including autonomous summarization and question answering, have been developed to aid in understanding scientific literature. However, these tools lack the structured, multi-step approach necessary for extracting deep insights from scientific literature. Large Language Models (LLMs) offer new possibilities for literature analysis, but remain unreliable due to hallucinations and incomplete extraction. We introduce Elhuyar, a multi-agent, human-in-the-loop system that integrates LLMs, structured AI, and human scientists to extract, analyze, and iteratively refine insights from scientific literature. The framework distributes tasks among specialized agents for filtering papers, extracting data, fitting models, and summarizing findings, with human oversight ensuring reliability. The system generates structured reports with extracted data, visualizations, model equations, and text summaries, enabling deeper inquiry through iterative refinement. Deployed in materials science, it analyzed literature on tungsten under helium-ion irradiation, showing experimentally correlated exponential helium bubble growth with irradiation dose and temperature, offering insight for plasma-facing materials (PFMs) in fusion reactors. This demonstrates how AI-assisted literature review can uncover scientific patterns and accelerate discovery.

Housing selection is a high-stakes and largely irreversible decision problem. We study housing consultation as a decision-support interface for housing selection. Existing housing platforms and many LLM-based assistants often reduce this process to ranking or recommendation, resulting in opaque reasoning, brittle multi-constraint handling, and limited guarantees on factuality. We present HabitatAgent, the first LLM-powered multi-agent architecture for end-to-end housing consultation. HabitatAgent comprises four specialized agent roles: Memory, Retrieval, Generation, and Validation. The Memory Agent maintains multi-layer user memory through internal stages for constraint extraction, memory fusion, and verification-gated updates; the Retrieval Agent performs hybrid vector--graph retrieval (GraphRAG); the Generation Agent produces evidence-referenced recommendations and explanations; and the Validation Agent applies multi-tier verification and targeted remediation. Together, these agents provide an auditable and reliable workflow for end-to-end housing consultation. We evaluate HabitatAgent on 100 real user consultation scenarios (300 multi-turn question--answer pairs) under an end-to-end correctness protocol. A strong single-stage baseline (Dense+Rerank) achieves 75% accuracy, while HabitatAgent reaches 95%.

Large language model (LLM) agents are increasingly deployed in competitive multi-agent settings, raising fundamental questions about whether they converge to equilibria and how their strategic behavior can be characterized. In this paper, we study LLM agent interactions in two standard games: a network resource allocation game and a Cournot competition game. Rather than converging to Nash equilibria, we find that LLM agents tend to cooperate when given multi-round prompts and non-zero-sum context. Chain-of-thought analysis reveals that fairness reasoning is central to this behavior. We propose an analytical framework that captures the dynamics of LLM agent reasoning across rounds and explains these experimental findings.

In recent years, the advances of large language models and autonomous agents have revolutionized the healthcare field, facilitating diagnosis and improving treatment results. However, most existing AI systems rely on pre-trained knowledge and predefined pipelines, which struggle to learn dynamically from the interactive chat session history that contains patient outcomes and past failures. To address this limitation, we propose VIBEMed, a multi-agent framework with a built-in self-evolution mechanism and architecture-level safety sandbox for robust clinical decision support. The system integrates three specialized agents, including a Clinical Diagnostic Agent (CDA) for hypothesis generation, a Therapeutic Execution Agent (TEA) for treatment planning, and a Clinical Evolution Manager Agent (CEMA) that distills longitudinal clinical feedback into reusable knowledge, transforming multimodal patient information into personalized medical decisions. Through self-evolution mechanism, the framework enables iterative updates across memory, model behavior, and decision strategies, allowing the system to improve over time. Experimental results show that VIBEMed demonstrates superior performance through its evolving mechanism in complex clinical cases, particularly in tasks that require integrated decision-making and longitudinal planning. The framework also supports reliable end-to-end decisions in challenging scenarios such as oncology treatment planning, highlighting its feasibility in real-world clinical contexts. Overall, VIBEMed provides a practical path beyond static AI systems toward adaptive, experience-driven clinical decision support, demonstrating the value of combining multi-agent collaboration with continuous evolution for advancing precision medicine.

We formally introduce a improvisational wordplay game called Connections to explore reasoning capabilities of AI agents. Playing Connections combines skills in knowledge retrieval, summarization and awareness of cognitive states of other agents. We show how the game serves as a good benchmark for social intelligence abilities of language model based agents that go beyond the agents' own memory and deductive reasoning and also involve gauging the understanding capabilities of other agents. Finally, we show how through communication with other agents in a constrained environment, AI agents must demonstrate social awareness and intelligence in games involving collaboration.

Single-agent large language model (LLM) systems struggle to simultaneously support diverse conversational functions and maintain safety in behavioral health communication. We propose a safety-aware, role-orchestrated multi-agent LLM framework designed to simulate supportive behavioral health dialogue through coordinated, role-differentiated agents. Conversational responsibilities are decomposed across specialized agents, including empathy-focused, action-oriented, and supervisory roles, while a prompt-based controller dynamically activates relevant agents and enforces continuous safety auditing. Using semi-structured interview transcripts from the DAIC-WOZ corpus, we evaluate the framework with scalable proxy metrics capturing structural quality, functional diversity, and computational characteristics. Results illustrate clear role differentiation, coherent inter-agent coordination, and predictable trade-offs between modular orchestration, safety oversight, and response latency when compared to a single-agent baseline. This work emphasizes system design, interpretability, and safety, positioning the framework as a simulation and analysis tool for behavioral health informatics and decision-support research rather than a clinical intervention.

As AI agents evolve, the community is rapidly shifting from single Large Language Models (LLMs) to Multi-Agent Systems (MAS) to overcome cognitive bottlenecks in automated research. However, the optimal multi-agent coordination framework for these autonomous agents remains largely unexplored. In this paper, we present a systematic empirical study investigating the comparative efficacy of distinct multi-agent structures for automated machine learning optimization. Utilizing a rigorously controlled, execution-based testbed equipped with Git worktree isolation and explicit global memory, we benchmark a single-agent baseline against two multi-agent paradigms: a subagent architecture (parallel exploration with post-hoc consolidation) and an agent team architecture (experts with pre-execution handoffs). By evaluating these systems under strictly fixed computational time budgets, our findings reveal a fundamental trade-off between operational stability and theoretical deliberation. The subagent mode functions as a highly resilient, high-throughput search engine optimal for broad, shallow optimizations under strict time constraints. Conversely, the agent team topology exhibits higher operational fragility due to multi-author code generation but achieves the deep theoretical alignment necessary for complex architectural refactoring given extended compute budgets. These empirical insights provide actionable guidelines for designing future autoresearch systems, advocating for dynamically routed architectures that adapt their collaborative structures to real-time task complexity.

Metal-organic frameworks (MOFs) offer a vast design space, and as such, computational simulations play a critical role in predicting their structural and physicochemical properties. However, MOF simulations remain difficult to access because reliable analysis require expert decisions for workflow construction, parameter selection, tool interoperability, and the preparation of computational ready structures. Here, we introduce SimMOF, a large language model based multi agent framework that automates end-to-end MOF simulation workflows from natural language queries. SimMOF translates user requests into dependency aware plans, generates runnable inputs, orchestrates multiple agents to execute simulations, and summarizes results with analysis aligned to the user query. Through representative case studies, we show that SimMOF enables adaptive and cognitively autonomous workflows that reflect the iterative and decision driven behavior of human researchers and as such provides a scalable foundation for data driven MOF research.

Formative feedback is central to effective learning, yet providing timely, individualised feedback at scale remains a persistent challenge. While recent work has explored the use of large language models (LLMs) to automate feedback, most existing systems still conceptualise feedback as a static, one-way artifact, offering limited support for interpretation, clarification, or follow-up. In this work, we introduce REFINE, a locally deployable, multi-agent feedback system built on small, open-source LLMs that treats feedback as an interactive process. REFINE combines a pedagogically-grounded feedback generation agent with an LLM-as-a-judge-guided regeneration loop using a human-aligned judge, and a self-reflective tool-calling interactive agent that supports student follow-up questions with context-aware, actionable responses. We evaluate REFINE through controlled experiments and an authentic classroom deployment in an undergraduate computer science course. Automatic evaluations show that judge-guided regeneration significantly improves feedback quality, and that the interactive agent produces efficient, high-quality responses comparable to a state-of-the-art closed-source model. Analysis of real student interactions further reveals distinct engagement patterns and indicates that system-generated feedback systematically steers subsequent student inquiry. Our findings demonstrate the feasibility and effectiveness of multi-agent, tool-augmented feedback systems for scalable, interactive feedback.

The way we're thinking about generative AI right now is fundamentally individual. We see this not just in how users interact with models but also in how models are built, how they're benchmarked, and how commercial and research strategies using AI are defined. We argue that we should abandon this approach if we're hoping for AI to support groundbreaking innovation and scientific discovery. Drawing on research and formal results in complex systems, organizational behavior, and philosophy of science, we show why we should expect deep intellectual breakthroughs to come from epistemically diverse groups of AI agents working together rather than singular superintelligent agents. Having a diverse team broadens the search for solutions, delays premature consensus, and allows for the pursuit of unconventional approaches. Developing diverse AI teams also addresses AI critics' concerns that current models are constrained by past data and lack the creative insight required for innovation. The upshot, we argue, is that the future of transformative transformer-based AI is fundamentally many, not one.