Deep Learning Framework

Myocardial strain from echocardiography is a key biomarker for cardiac function. Recent deep learning methods show strong performance for myocardial motion tracking but often lack physiological constraints, leading to temporal drift across the cardiac cycle. Consequently, tracked points may not return to their relative initial positions at the end of each cardiac cycle, producing inaccurate strain estimates and even divergence in some cases. We propose a deep learning framework that compensates for drift during myocardial tracking. We extend a state-of-the-art echocardiographic tracking method (TAS-Net) with persistent memory tokens that share information across sliding windows over full cardiac cycles. A teacher-student fine-tuning strategy on real echocardiographic data then enforces physiologically consistent cyclic motion while preserving tracking accuracy. Experiments show reduced global and regional strain drift, improved agreement with clinical references, and better test-retest reproducibility, supporting more reliable myocardial strain estimation in clinical practice.

Longitudinal single cell atlases now capture matched pre treatment and post treatment states from responders and non responders, presenting an opportunity to mechanistically explain why two patients on the same drug diverge. We introduce scDEFT (single cell Drug EFfect Transducer), which treats a drug as a conditioning operator on cell representations, enabling prediction and explanation. In scDEFT, feature wise linear modulation produces drug conditioned cell latents, learned under abundant per cell supervision and then frozen. Two independent heads aggregate those latents over shared transcriptional neighborhoods to predict drug induced state change and responder status. A backward stage ranks the latent dimensions by how strongly they separate responders from non responders and maps them to genes under a cell composition control. On a harmonized inflammatory bowel disease atlas of 1.16 million cells, three cohorts and two drug classes, scDEFT predicts state change at 45% of the baseline to reproducibility ceiling headroom and stratifies responders before treatment at AUROC 0.70, where standard predictors remain at chance. These predictions and the drivers behind them support target and co target nomination, patient stratification, and counterfactual prediction of unseen drug cohort effects.

False ventricular tachycardia (VT) alarms are a leading contributor to alarm fatigue in intensive care units. We propose a deep learning framework combining a 1D SE-ResNet with ICU-realistic data augmentations and a physics-informed auxiliary reconstruction task based on the three-element Windkessel hemodynamic model, implemented as a differentiable forward simulation. By requiring the network's latent representation to produce physiologically plausible arterial pressure waveforms, artifact-driven ECG patterns are penalized while true VT remains coherent across modalities. Evaluated on the VTaC benchmark under a strict real-time protocol (10-second pre-alarm window), our method achieves a 5-point Challenge Score improvement over prior state-of-the-art. Ablation studies confirm that the physics-informed objective is the primary performance driver, providing gains in accuracy, 2x label efficiency, and more localized and clinically meaningful ECG segments.

Fibre optic sensing, such as distributed acoustic sensing (DAS), has become a widespread technology for geophysical studies. To process the large-scale datasets produced by DAS, several machine learning methods have been proposed. However, without standardization of data and models, these methods lack comparability and interoperability. This introduces a gap between model developers and practitioners analyzing DAS data and inhibits adoption of deep learning for DAS. To address these limitations, here we present SeisBench DAS, an extension to the SeisBench library for machine learning in seismology. SeisBench DAS defines standard formats for DAS benchmark datasets, including standardised metadata and labels, and DAS models. It builds on the xdas framework for data ingestion and virtual array handling, and on PyTorch for reading and applying the machine learning models. Importantly, SeisBench provides an engine to efficiently apply deep learning models to diverse formats of DAS data, bridging the gap between model developers and practitioners. SeisBench DAS is designed as an open and extensible framework, allowing to easily incorporate future developments in deep learning for DAS.

Anti-UAV systems increasingly fuse multiple sensors, yet their detection heads provide no per-modality reliability signal. This study evaluates whether evidential deep learning (EDL) heads, Dempster-Shafer (DS) evidence fusion, and uncertainty-driven temporal sensor gating improve anti-UAV detection through a controlled ablation on three benchmarks: thermal tracking (AntiUAV600), RGB-audio-RF classification (TRIDENT), and RGB-IR tracking (MM-UAV). The EDL training objective improves accuracy over retrained sigmoid baselines (+5.9 percentage points in accuracy and a tripled tracker-on-absent rate in E1; +4.8 percentage points in classification accuracy in E2, surviving a clip-clustered bootstrap, p = 0.011) and ranks classification errors substantially better (entropy UAUC approximately 0.94 vs. 0.51). The remaining components do not support their respective hypotheses. DS fusion does not outperform simple probability averaging. Dirichlet vacuity adds no ranking power beyond predictive entropy and inverts at the detection level, where extreme background imbalance causes it to encode class membership rather than error likelihood, a failure also observed for entropy and sigmoid confidence. Temporal gating preserves accuracy only when nearly inactive and yields no realised latency saving on shared-backbone hardware. The benefit of evidential learning therefore arises primarily from its training objective rather than its uncertainty estimate; a crop-level control further localises the detection-level breakdown to anchor-level evaluation rather than the learned representation.

Electroencephalography (EEG) is a promising, non-invasive, and cost-effective modality for Alzheimer's disease (AD) detection, but deep learning methods are limited by small and imbalanced clinical datasets. Generative augmentation offers a solution, yet existing approaches rely on inefficient class-specific models or fail to capture complex spatial and temporal brain dynamics. To address this, we propose GraM-Diff, a unified classifier-guided Graph-Mamba diffusion framework for EEG synthesis. It embeds Graph Convolutional Networks within a diffusion U-Net to model inter-electrode connectivity and Bidirectional Mamba state-space blocks for linear-complexity long-range temporal modeling. Latent-space classifier guidance lets a single model generate both healthy and pathological EEG within a shared representation, avoiding fragmented per-cohort pipelines. Across four EEG-based AD benchmarks, synthetic augmentation improves classification, yields superior Context-FID and correlation scores over strong generative baselines, and enhances robustness in data-scarce settings.

Consumer reviews play an important role in shaping brand perception and business strategies, particularly in service-driven industries such as retail coffee. This study presents a comparative sentiment analysis framework for Starbucks customer reviews using classical machine learning and deep learning approaches. The dataset, collected from ConsumerAffairs, contains more than 700 reviews and was analyzed through preprocessing and exploratory data analysis to identify temporal and geographic patterns. Sentiment labels were generated by binarizing star ratings, with ratings of 4 and 5 classified as positive and ratings of 1 to 3 as negative. The resulting dataset was substantially imbalanced toward negative sentiment. Five machine learning classifiers, including Logistic Regression, Support Vector Machine (SVM), Decision Tree, Random Forest, and Naive Bayes, were evaluated alongside five deep learning models: LSTM, RNN, Bidirectional LSTM, GRU, and CNN. Model performance was assessed using accuracy, precision, recall, and F1-score. SVM achieved the highest accuracy among the machine learning models at 91.0 percent, while Bidirectional LSTM showed the strongest performance among the deep learning models and demonstrated good generalization on unseen data. The findings also show that class imbalance negatively affected positive sentiment recall across several models. Overall, this study provides a comparative evaluation of machine learning and deep learning approaches for real-world consumer sentiment analysis and highlights the importance of appropriate model selection and preprocessing for customer experience analytics in the retail coffee sector.

Assessing catheter and tube placement on chest X-rays is safety-critical yet tedious and error-prone. Current deep learning methods either classify placement globally -- losing track of which device is where -- or segment all devices into a single mask, making per-device assessment impossible when catheters overlap. We introduce UCompCXR, a compositional framework that detects local catheter fragments, associates them into device instances via graph-based clustering, fuses per-fragment tip predictions through precision-weighted Gaussian estimation, and classifies placement per device. On the RANZCR CLiP dataset (30,083 images, 5-fold patient-level CV with bootstrap CIs), UCompCXR detects 26% more devices than a strong multi-task baseline sharing the same MobileNetV3 backbone, with 75% fewer false positives and well-calibrated tip uncertainty (95% coverage = 0.948). The aggregate tip error rises -- but only because the model finds devices the baseline misses entirely, especially nasogastric tubes. On matched devices, catastrophic localization failures drop substantially. At 2.27M parameters in a single forward pass, the model is deployable on resource-constrained clinical hardware.

Skin cancer diagnosis from dermoscopic images remains challenging due to high intra-class variability, inter-class similarity, class imbalance, and the limited interpretability of deep learning models. This paper proposes an uncertainty-aware and explainable deep learning framework for multi-class skin lesion classification. The framework combines a vision transformer model (MaxViT-Tiny) with CNN-based models (ConvNeXt-Tiny and EfficientNetV2-B0) through deep ensemble learning. Monte Carlo (MC) Dropout estimates predictive uncertainty and identifies unreliable predictions, while Grad-CAM++, an explainable AI (XAI) technique, provides visual explanations by highlighting lesion regions that influence model decisions. Evaluated on the HAM10000 dataset, the framework achieves 96% accuracy and 99% ROC-AUC under uncertainty-aware filtering (entropy < 1.0, confidence >= 0.7), with macro-average precision, recall, and F1-score of 94%, 95%, and 95%, respectively, and 96% weighted-average scores across all three metrics. The results demonstrate accurate, interpretable, and uncertainty-aware skin lesion classification for trustworthy computer-aided diagnosis.

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, predominantly arising from precancerous polyps. Accurate detection, segmentation, and endoscopic and histological classification of colorectal polyps are crucial for timely clinical intervention. In this study, we present PolypVision, a three-stage hierarchical deep learning framework that sequentially performs: (Stage 1) binary classification of polyps as adenomatous or hyperplastic, with simultaneous Paris and JNet classification, using EfficientNetV2-M with Focal Loss; (Stage 2) polyp segmentation with recommended resection method using a UNet++ decoder with the Stage 1 backbone as encoder, optimized with Dice and BCE losses; and (Stage 3) adenoma subtype classification (tubular, tubulovillous, villous) using EfficientNetV2-M with transfer learning from Stage 2. Evaluated on three public datasets -- PolypGen, Kvasir-SEG, and CVC-ClinicDB -- PolypVision achieves an AUC of approximately 0.99 for frame classification and a detection mAP@50 of 94.4% on Kvasir-SEG, outperforming or matching state-of-the-art methods. Gradient-weighted Class Activation Maps (Grad-CAM) confirm that the model attends to clinically relevant lesion features. The framework is device-independent, operating across diverse endoscopic imaging systems without hardware-specific adaptation. These results demonstrate that a hierarchical, transfer-learning-driven pipeline with task-specific loss functions offers a robust, device-independent, and clinically meaningful approach to automated colorectal polyp analysis. PolypVision is freely available as a web application at https://polypvision.com, a DataBioX initiative, with a free usage tier open to all users.

Alzheimer's disease (AD) progression is a longitudinal process with subtle pathological cues in the early stages. Yet, computational constraints have limited most neuroimaging models to either compromise spatial information or limit the number of longitudinal scans. We aim to overcome this bottleneck and fully leverage high-resolution, variable-length T1w structural MRI (4D sMRI) scan sequences. We introduce Parcel2Progression (P2P), a Longitudinal Transformer Framework which tackles this challenge using an Atlas-guided Parcel Encoder that tokenizes 3D scans into a set of richer anatomically grounded representations. A Longitudinal Transformer then integrates irregular, arbitrary-length longitudinal visits with patient age. This synergy delivers two key advantages: (1) parcel-specific interpretability, and (2) computational tractability for long-term analysis, which scales linearly with the number of scans compared to a naive quadratic 4D ViT cost. P2P outperforms prior works and baselines in both MCI (Mild Cognitive Impairment) to AD conversion prediction and AD vs. CN (Cognitively Normal) classification tasks across ADNI, AIBL, and MIRIAD datasets. Leveraging longitudinal scans boosts performance over single-scan baselines by up to 5% and 7% in balanced accuracy for AD classification and MCI conversion prediction tasks, respectively. Interpretability analysis using parcel saliencies and attention rollouts reveals clinically consistent atrophy patterns in AD and MCI subjects. We also demonstrate the frameworks' reliability in anomaly detection using a synthetic dataset, and test the model's generalizability for other neurodegenerative diseases like Frontotemporal Dementia.

Video anomaly detection (VAD) is a critical yet challenging task due to the complex and diverse nature of real-world scenarios. Traditional deep learning approaches are fundamentally limited by poor generalization across diverse scenarios. While multimodal agents offer a promising tool-learning paradigm for VAD, current systems relying on supervised fine-tuning struggle with complex orchestration, and standard reinforcement learning often causes premature termination due to coarse-grained outcome rewards. To address these challenges, we propose VTO, a process-supervised reinforcement learning framework. Moving beyond static tool usage, VTO enables the agent to dynamically explore and interact with the environment. Specifically, we introduce a foundation model-driven cognitive evaluator to provide context-aware semantic feedback, which is seamlessly integrated into a Process-Supervised Cognitive Alignment that delivers fine-grained, step-wise supervision. By explicitly penalizing logical truncation and rewarding complete causal chains, the agent optimizes its multi-step reasoning policy for interrelated tool orchestration. To support our proposed framework, we meticulously crafted VAD-Tool, a hierarchical visual tool set comprising 12 specialized vision tools spanning from entity tracking to high-stakes hazard detection, and established the corresponding benchmark for rigorous multi-step reasoning evaluation. Extensive experiments on VAD-Tool demonstrate that VTO significantly outperforms baselines, achieving up to a 10.2% absolute accuracy improvement in tool scheduling. Code and data are available at https://github.com/MICLAB-BUPT/VTO.

Functional Magnetic Resonance Imaging ( fMRI ) data are often pooled into collaborative multi-site consortia, as deep learning models for analyses require large datasets to generalize well. While Federated Learning (FL) offers a privacy-preserving paradigm for collaborative training, standard approaches continue to struggle with statistical heterogeneity. In particular, site differences pose a key challenge in multi-site data settings. Additionally, existing FL approaches for fMRI rely on static Functional Connectivity ( FC), omitting dynamic information in brain networks. To address this, we propose FedDOSE, a novel framework that explicitly decomposes site differences for analysis of dynamic FC (dFC). FedDOSE introduces a Modularity-Guided Tucker Decomposition block to encode high-dimensional dFC tensors and capture modular-level spatio-temporal patterns efficiently. Class-specific prototypes are generated across all sites and subsequently aligned at the global level by using a combination of Optimal Transport (OT) barycenter formulation and Procrustes analysis. Extensive experiments for diagnosing Autism Spectrum Disorder (ASD) and Attention-Deficit Hyperactivity Disorder (ADHD) on three multi-site resting-state fMRI datasets: ABIDE-I, ABIDE-II, and ADHD-200, demonstrate that FedDOSE outperforms state-of-the-art methods in ASD and ADHD detection. Our results highlight its effectiveness in learning robust representations from multi-site datasets for reliable analysis.

Accurate solar irradiance forecasting is essential for the reliable integration of photovoltaic power into modern electricity grids. All-sky imagers (ASI) provide high-resolution observations of clouds, making them well suited for intra-hour forecasting. Recent deep learning approaches have substantially improved forecast accuracy but are often limited by deterministic predictions and a reduced capability to anticipate ramp events. This work proposes FarSky, a generative forecasting framework that leverages latent-space coupling to learn task-aware representations of sky images. A multi-task autoencoder first learns a shared latent representation for image reconstruction and irradiance estimation. A latent diffusion model then generates future latent states conditioned on recent observations, from which irradiance forecasts are directly decoded. Probabilistic forecasts are inherently obtained through stochastic sampling. The framework is developed using a multi-year ASI dataset acquired at the Plataforma Solar de Almería, Spain, and evaluated on two independent test datasets against persistence, state-of-the-art end-to-end, and generative forecasting approaches. FarSky achieves the best overall deterministic and probabilistic forecasting performance, improving forecast skill by up to 11 percentage points. Furthermore, it substantially improves ramp event detection over existing methods, achieving F1-scores above 60%. These results demonstrate the potential of combining generative models with task-aware latent-space coupling for solar forecasting.

Microwave ablation (MWA) is a promising minimally invasive treatment for liver tumors, but its therapeutic outcome strongly depends on patient-specific planning of antenna insertion trajectory, power, and treatment duration. Accurate numerical simulation can provide physically reliable ablation predictions; however, its high computational cost limits its use in optimization-based planning, where repeated forward evaluations are required. To address this issue, we propose a digital twin-based automatic planning framework that combines a neural ablation prediction model with a genetic algorithm. The model was trained on multiphysics simulation data generated from patient-specific tumor and vessel structures, antenna configurations, and treatment conditions, and was used as a fast forward model during planning. The prediction model achieved a Dice score of 95.1%, enabling accurate deep learning-based optimization. In 13 unseen planning cases, the proposed method improved ablation efficiency by 54.3% and reduced organ damage by 55.0% compared with clinician-defined planning, while slightly shortening the insertion path length by 3.3%. Most generated plans were also judged clinically applicable by MWA specialists. Furthermore, the framework enabled approximately 420-fold faster planning than numerical-simulation-based planning, demonstrating its potential as a fast digital twin for quantitative and personalized MWA treatment planning. The code is available at: https://github.com/SeonAengCho/MWA-Planning.git

Historical lenticular films, such as those created with the Kodacolor process, encode color information in a distinctive spatial format. This structure requires specialized techniques for accurate color reconstruction. While recent signal processing approaches like doLCE and deep learning methods like deep-doLCE have advanced automated color recovery, they often fail with cases such as curved lenticules, low-contrast, or badly captured regions. We propose a human-in-the-loop (HITL) deep learning framework which is designed for color reconstruction in lenticular films. Our approach introduces an editable, vector-based representation of lenticule boundaries, allowing experts to interactively refine boundary positions before color extraction and demosaicing. This decoupled architecture enables targeted corrections and iterative fine-tuning, embedding expert knowledge into the detection model and improving robustness across challenging frames. To preserve image details using information solely present in the original silver emulsion, we merge the reconstructed chrominance with the original film scan's luminance. We evaluate our pipeline on a challenging lenticular film sequence where previous automated approaches fail and the reconstructed colors are not suitable for exhibition. In contrast, our HITL approach successfully produces high-quality, exhibitable color reconstructions with preserved texture. This work is the first to combine expert guidance, editable intermediate representations, and texture-preserving post-processing for lenticular film color reconstruction, advancing the state of the art in this field.

Deformable image registration (DIR) is a core problem in medical image analysis; but, unlike labeling decision problems such as classification and segmentation, registration is a problem class that involves stringent physical constraints. Although deep learning methods have made faster registration possible, the resulting models are often difficult to interpret compared to hand-crafted methods with explicit objectives and interpretable physical meaning. In this work, we show that an analytical method can still yield competitive and superior results to deep learning in a common deformable registration task. We study pTVreg as a parametric total variation based registration in that context. Observing its different implementations to perform at various degrees, we introduce here an accessible implementation of this method, together with a Bayesian optimization framework that automatically sets self-parameters for any DIR task from a set of sample examples. Experiments on Lung250M-4B show that our proposed implementation achieves state-of-the-art results in this benchmark, substantially superior to existing deep learning solutions and other pTVreg variants as baselines. The source code will be made publicly available at https://github.com/oazeybekoglu/ptvreg-python .

Rapid and accurate post-disaster building damage assessment is essential, yet remains a challenging task. Unmanned Aerial Vehicle (UAV) imagery offers a timely and high-resolution view of affected areas, but existing Computer Vision (CV) models often demand large annotated datasets, generalize poorly across geographic regions and their assessment policies, and are confined to the specific tasks they were trained for. Large Vision-Language Models (LVLMs) offer a promising alternative through their strong reasoning and generalization capabilities, but fall short on precise, low-level perception tasks such as object detection and accurate bounding box generation. Furthermore, they often require a substantial amount of data for effective fine-tuning on domain-specific tasks. In this paper, we propose a hybrid framework that decouples detection from damage assessment, combining the precision of CV models with the reasoning power of LVLMs. A CV model first detects buildings and generates bounding boxes on the image that are then passed to an LVLM for damage classification and contextual interpretation. We evaluated our framework on two real-world benchmarks: RescueNet and FloodNet. In particular, the best combination under this framework accurately counts intact, partially damaged and completely destroyed buildings, surpassing isolated baselines by up to 2.1 R^2 points, while requiring only limited annotated data for the detection stage. Beyond reporting aggregate gains, we provide a detailed analysis of failure scenarios and edge cases, offering practical insights for practitioners and concrete directions for future work. Our source code and data are publicly available to the research community via the following repository: https://github.com/ungquanghuy-kddi/VLM_GDINO.git

While deep learning models have achieved state-of-the-art performance in time series anomaly detection, their complex architectures incur substantial inference overhead. Existing methods typically apply a uniform inference strategy across all data points, which is inefficient given that anomalies are inherently scarce and the vast majority of temporal data consists of predictable normal patterns. To mitigate this bottleneck, we propose CARE, a model-agnostic cascaded inference framework that integrates a Lightweight Pre-filter Model (LPM) with an existing high-capacity Complex Detection Model (CDM). The LPM rapidly filters high-confidence normal samples using a Residual MLP AutoEncoder and a Normality-Conditioned Gating mechanism. Crucially, we introduce a Structure Attention module to explicitly capture channel-wise anomaly contributions, and optimize the gating network via a confidence-guided selective routing objective that learns reliable routing decisions to reduce unnecessary CDM invocations. Extensive experiments across eight real-world benchmarks demonstrate that CARE effectively isolates high-confidence normal samples. By routing only uncertain samples to the CDM, our framework achieves $2.7\times$ to $4.8\times$ inference speedup compared to the most accurate SOTA approaches, while still maintaining competitive detection quality.

Diffusion MRI (dMRI) relies on diffusion-weighted echo-planar imaging, which is highly susceptible to eddy-current-induced geometric distortions. These distortions vary across diffusion volumes according to gradient strength and direction, causing between-volume misalignment that can bias downstream microstructural analyses. Current state-of-the-art correction methods, such as FSL Eddy, achieve high-quality correction through iterative prediction-correction schemes but are computationally expensive. We propose Eddeep, a deep-learning framework for fast eddy-current distortion correction in dMRI. Eddeep decomposes the problem into two stages. First, a supervised image translation network standardises the appearance of diffusion-weighted and b=0 images, removing contrast differences that hinder reliable registration. Second, an unsupervised registration network estimates both eddy-current distortion and between-volume head motion parameters under a physics-constrained quadratic distortion model, enabling correction in a single forward pass. The method was trained on UK Biobank data and evaluated on both in-domain (UK Biobank) and out-of-domain (Memodyn) datasets. Across a range of complementary metrics, including between-volume jitter, diffusion kurtosis imaging residuals, signal irregularity, and mutual information, Eddeep achieved correction quality comparable to that of FSL Eddy while substantially reducing inference time. These results demonstrate that deep learning can provide accurate and efficient eddy-current distortion correction without relying on iterative optimisation, supporting the development of faster diffusion MRI processing pipelines for large-scale studies and clinical deployment. The code is available at: https://github.com/CIG-UCL/eddeep.

Road crashes remain among the gravest threats to public safety, and preventing them is a defining task of transportation systems worldwide. Much of that harm concentrates at hotspots, yet a hotspot is less a place than an episode; it emerges quietly at an intersection or along an arterial, intensifies for weeks, then subsides, only to reappear elsewhere. Enforcement guided by maps of past crashes inevitably trails this cycle, patrolling yesterday's hotspots while tomorrow's form unwatched. Breaking that lag requires three capabilities at once: detecting hotspots as they are born, forecasting where they will sit next week, and following each one through its life. We introduce HERALD (Hotspot Emergence, Risk Anticipation, and Life-cycle Dynamics), a unified deep learning framework that provides all three from a single statewide model. HERALD distills each county's recent crash history into weekly risk maps and forecasts the next with a CNN--Transformer, whose mixture-of-experts lets one model serve dense urban cores and sparse rural corridors alike. Each forecast is anchored in the county's long-run crash geography, sharpened by the self-exciting effect of recent crashes, and paired with explicit warnings of where new hotspots are about to appear. Followed over time, every hotspot acquires a legible life story, from birth through growth and stability to decline and death. Across six heterogeneous Wisconsin counties, HERALD forecasts more accurately than five identically trained baselines, locates hotspots most precisely, and flags emerging risks before they take hold. A single adjustable setting trades accuracy for extra sensitivity where deployment demands it. The result shifts hotspot management from mapping the past to anticipating the future.

Visual anomaly detection requires adaptive representations and reliable decision boundaries, particularly when anomalous training samples are scarce and class distributions are highly imbalanced. Classical kernel-based methods yield principled geometric decision regions but typically operate on fixed features, while deep detectors learn task-specific representations but often fail to provide an explicit margin-aware kernel boundary. In this study, we propose DLM-SVDD, a deep large-margin novelty-detection framework that jointly learns convolutional features and an explicit kernel-based decision boundary. By drawing on the large-margin $\ell_p$-Support Vector Data Description ($\ell_p$-SVDD) approach, the proposed method performs explicit margin maximization and nonlinear slack penalization while adapting the representation to the target task. To train the proposed model, we present an optimization scheme that alternates between a Frank--Wolfe--based update of the convex dual boundary and a CNN update step operating on a smooth margin-violation loss induced by the recovered boundary. To improve scalability, we analyze the efficiency--accuracy trade-offs for different kernel approximation strategies, deriving practical propositions for large-scale anomaly detection. Extensive experiments on multiple standard benchmarks show consistent performance improvements over the baseline and strong overall performance compared with state-of-the-art methods while illustrating that the proposed joint representation--boundary learning scheme remains effective under severe imbalanced class distributions.

Repetitive transcranial magnetic stimulation (rTMS) is a non invasive therapy for Major Depressive Disorder (MDD). In this study, we generate images using two time frequency methods to represent EEG signals: Fourier-Bessel Series Expansion with Euclidean Distance (FBSE-ED) and Discrete Wavelet Transform (DWT). We propose an efficient deep learning classifier to predict the outcome of rTMS depression therapy. In this study, we use a private rTMS databases to train a lightweight custom Convolutional Neural Network (CNN) using 10-fold cross validation strategy in order to avoid any bias in our results. The results show that the FBSE-ED representation achieves the highest classification accuracy of 93.60%, outperforming traditional time-frequency technique (DWT). In addition, the proposed architecture with FBSE-ED image representation technique outperforms more complex EEG-Specific deep learning models (EEGNet, DeepConvNet, SleepEEGNet) by 3.62-10.72% and pretrained models (Xception, DenseNet201, and MobileNetV2) by 23.03-27.35%. For more experiments, we utilize another private rTMS database as test database to show the robustness of the proposed model. Our results suggest that integrating advanced signal decomposition with deep learning can facilitate early prediction of rTMS treatment response and support more targeted clinical decision-making. The proposed framework is interpretable, computationally efficient, and well-suited for deployment in real-world local psychiatric clinics.

Leaf veins exhibit remarkable diversity in architecture and patterning, yet existing gene--environment association studies have primarily quantified leaf venation using a small collection of low-dimensional summary traits, thereby discarding most of the structural information contained in the original images. We propose an integrated deep learning and statistical framework. The proposed framework achieves four methodological advances. First, it represents the complete leaf vascular architecture as a whole-network image phenotype. Second, it fine-tunes the deep learning-based Edge Detection with Transformers (EDTER) model to accurately extract whole-network leaf vascular architecture from RGB images by jointly learning local and global contextual features. Third, it constructs a new annotated leaf image database by integrating edge maps generated by DiffusionEdge with the Berkeley Segmentation Database (BSDS500). Fourth, it applies Semiparametric Sparse Canonical Correlation Analysis (SSCCA) to perform variable selection and model associations between repeatedly measured high-dimensional Bivariate image responses and high-dimensional predictors while simultaneously accommodating sparse, zero-inflated data represented by edge maps through a truncated latent Gaussian copula model. Two simulation studies demonstrate the performance of the proposed framework under increasing levels of complexity. Application to a real \emph{Populus} dataset identifies three significant gene--geography interactions associated with leaf vascular architecture, providing new biological insights and establishing a broadly applicable methodological framework for high-dimensional complex image phenotypes.

18F-FDG PET/CT plays a central role in staging, treatment planning, and response assessment for head and neck cancer by providing functional information that complements anatomical CT imaging. However, PET acquisition requires radiotracer administration, specialized infrastructure, and additional cost, limiting its availability for repeated imaging. We present a proof of concept deep learning framework for synthesizing PET like images directly from routine CT scans with the goal of providing complementary metabolic information that may support imaging triage and clinical decision support rather than replace diagnostic PET. Forty-four patients from the publicly available QIN-HEADNECK dataset were retrospectively analyzed using five fold cross-validation. We propose a fully three dimensional dual path architecture consisting of (i) a regression U-Net optimized for voxel-wise quantitative SUV estimation and (ii) a conditional generative adversarial network optimized for realistic PET texture. Their outputs are integrated using hotspot guided Laplacian pyramid blending, allowing quantitative information from the regression pathway to be preserved within metabolically active regions while leveraging adversarial texture synthesis elsewhere. The proposed framework achieved a mean absolute error of 0.00395, PSNR of 39.19 dB, and SSIM of 0.9634 on reconstructed three dimensional PET volumes. Qualitative evaluation demonstrated accurate localization of many FDG-avid lesions while producing anatomically realistic background texture. Consistent with previous CT to PET synthesis studies, the principal limitation was systematic underestimation of SUV within highly metabolically active tumor regions.

Acoustic impedance imaging is a fundamental yet severely ill-posed problem in subsurface analysis: the seismic wavelet is unknown, observations are band-limited, and labeled well-log samples are extremely scarce (typically <1% of all traces). Existing semi-supervised deep learning methods mitigate few-shot problem by incorporating forward modeling, yet they either rely on inaccurate prior wavelet assumptions or introduce auxiliary networks, leading to unstable optimization and degraded performance. We propose RD-SCL, a novel framework that integrates regularized deconvolution with semi-supervised cross-learning. At its core lies a differentiable, closed-form first-order Tikhonov deconvolution operator that dynamically estimates the latent wavelet in the frequency domain during training, providing stable physics-guided feedback without explicit auxiliary networks and fixed wavelet priors. Building on this operator, we design a symmetric cross-learning that enforces consistency between predictions on labeled and unlabeled data, thereby effectively exploiting abundant unlabeled traces. Extensive experiments on the SEAM and Marmousi 2 benchmarks demonstrate that RD-SCL consistently outperforms state-of-the-art supervised and semi-supervised methods, achieving substantial gains with lower computational cost. With only 56.5k learnable parameters and competitive runtime, RD-SCL offers a practical, physically consistent, and efficient solution for acoustic impedance imaging.

We present FlareEUV, a multimodal deep learning framework for predicting daily extreme ultraviolet (EUV) irradiance at 6.5 nm over three consecutive days during significant solar flares, using multi-instrument observations from NASA's Solar Dynamics Observatory (SDO). We consider 33 significant flares in the period between 2011 and 2014 in Solar Cycle 24. The SDO observations include 13 co-aligned full-disk images, comprising eight AIA EUV/UV and five HMI magnetic/continuum products. FlareEUV learns the relationship between magnetic structure and coronal emission from the raw imaging data using a lightweight attention-based architecture. Our experimental results demonstrate the good performance of FlareEUV in short-term EUV irradiance forecasting during the significant flares and its superiority over baseline methods.

This work focuses on training Automatic Target Recognition (ATR) models using simulated Synthetic Aperture Radar (SAR) images to circumvent the lack of real measurements. To obtain robust and versatile ATR models, simulation needs to generate massive datasets that encompass all the variability found in real measurements. Thus, we need a simulator that finds a good tradeoff between execution speed, computational resource consumption, and physical representativeness. In this work, we demonstrate that the Salsa simulator addresses this issue. We ran computing performance tests to show that Salsa can generate 21,600 synthetic images in less than 10 minutes using a single Nvidia GeForce RTX 4090 GPU. Using our ADASCA Deep Learning approach, we demonstrate that these data are sufficiently representative to train ATR models and reach state-of-the-art results on the MSTAR public dataset with an accuracy of 86 %. To illustrate how Salsa unlocks new possibilities to train ATR models, we use the simulator to conduct a study on Electromagnetic (EM) couplings between the targets and their immediate environment. We demonstrate that, if not accounted for in the training dataset, the variability of the EM couplings induced by the variability of the ground surfaces can significantly degrade the performance of ATR models, with an accuracy decrease of more than 4 %. We also show that Salsa can generate in a timely manner (i.e., in less than 4 hours using the same GPU as previously) a massive dataset of 648,000 images with a large variety of couplings to make the ATR models robust to EM coupling variations. Our ATR models can then achieve an accuracy of 87 % on the MSTAR dataset.

ECoG-based visual semantic decoding enables inference of semantic interpretation of visual perception from complex, noisy brain activity. This study examines the feasibility of visual semantic decoding using an end-to-end deep learning framework using electrocorticography (ECoG). Specifically, the decoding task is to predict visual categories from video stimuli using time-series neural inputs. A previously collected ECoG dataset from participants ($n=17$) with drug-resistant epilepsy is used for analysis. With fewer than 50 training samples per visual category, this study evaluates multiple deep learning approaches, artificial neural network architectures, and frequency-band filtered inputs. The best-performing approach is analyzed to shed light on the discriminative information it relies on across spectral, temporal, and cortical dimensions. The selected decoding system uses mixup augmentation, a Transformer-based encoder, and high-gamma (80-150 Hz) inputs with a 900 ms post-stimulus window. Further analysis shows that early visual cortex (V2-V4), ventral stream visual cortex, MT+ complex with neighbouring visual areas, and lateral temporal cortex contributed substantially to decoding performance. This study demonstrates that an end-to-end deep learning framework can yield promising decoding performance from dynamic visual stimuli without handcrafted features, while the model behavior remains interpretable through spectral, temporal, and cortical dimensions, which are broadly consistent with established neuroscience knowledge.

Detecting vessels engaging in illegal activities is of paramount importance for maritime security. One of the major goals is to detect dark vessels, ships that disable their transponders to evade surveillance. Deep Learning (DL) models can detect vessels in Synthetic Aperture Radar (SAR) images, enabling maritime traffic analysis regardless of weather or visibility conditions. However, to detect potential dark vessels, a DL model must select only those that are required to carry a transponder based on their Gross Tonnage (GT). Unfortunately, no public SAR dataset is available for training an end-to-end DL model for vessel detection and GT regression. In this work, we present a framework that leverages heterogeneous image and tabular datasets to solve this task. Our solution combines a multi-task DL framework for predicting the location, vessel type, and physical dimensions of ships, cascaded with a non-parametric model for predicting GT from vessel size and category. We perform GT regression by a KNN that measures sample similarity using a hybrid Euclidean and categorical distance. Experiments show that our solution can predict multiple outputs while remaining competitive with state-of-the-art models on individual subtasks, thus enabling the identification of dark vessels. We publish our code on GitHub https://github.com/PaltrinieriDavide/vesseldetection.

The increasing complexity of next-generation wireless networks has driven the integration of artificial intelligence (AI) into wireless communications. However, most existing studies focus on developing task-specific deep learning techniques for single scenarios, which limits their ability to generalize across diverse tasks, channel conditions, and system configurations. To address this generalization bottleneck, we propose a hierarchical wireless foundation model (WFM) for multi-task optimization. The proposed WFM couples an upstream foundation channel encoder (FCE) with a downstream foundation optimization decoder (FOD) via geometry-aware cross-attention. Specifically, the FCE extracts task-agnostic channel representations via self-supervised masked reconstruction while the FOD generates multi-task optimization decisions through differentiable output heads. Moreover, a hybrid supervised-to-unsupervised training strategy is employed to overcome the performance ceiling of purely supervised learning, and the modular architecture of the WFM enables efficient adaptation to unseen communication tasks with minimal parameter overhead. Simulation results show that the proposed WFM learns high-fidelity channel representations and achieves competitive multi-task optimization performance while substantially reducing optimization inference latency relative to numerical baselines. Furthermore, it exhibits robust generalization to unseen propagation environments, varying constraint parameters, and heterogeneous system configurations.

Monitoring poverty and food security indicators is imperative for addressing socioeconomic challenges in developing nations. A limitation is mismatches in scale between data sources: census data provide geographic coverage, while socioeconomic indicators are derived from infrequently conducted surveys at coarse resolutions, posing a methodological challenge. This study introduces a deep learning framework, JuGAAD, using Indian census and survey data from 2001 and 2011 as a case study. We employ a three-step process: census and geospatial data are averaged into intermediate village-cluster-scale tessellations to reduce noise and regularize administrative boundary changes; an autoencoder compresses high-dimensional National Sample Survey Office (NSSO) data into a low-dimensional latent representation; and a regression model maps upscaled census and geospatial data to this representation. This function is applied to fine-grained census data to generate high-resolution predictions, validated against ground-truth district-level NSSO indicators. Results confirm the methodology predicts socioeconomic indicators at fine scales with strong accuracy.

High deployment cost, poor spatial coverage and susceptibility to storm conditions are all challenges faced by traditional in-situ methods. This paper presents a video-based and high performance computing (HPC) enabled deep learning framework for joint sensor free estimation of five coastal wave parameters, namely significant wave height (Hs), maximum wave height (Hmax), peak period (Tp), zero upcrossing period (Tz) and wave direction (theta) from monocular coastal video. The proposed architecture comprises of a V-JEPA (self supervised) ViT Small backbone for robust spatiotemporal feature extraction in visually challenging scenarios, a dual-stream SlowFast temporal encoder for broad bandwidth representation of wave motion in both hydrodynamic breaking and swell regimes, an optical flow stream based on Farneback optical flow algorithm for adding saliency information to the structure with emphasis on hydrodynamically active wavelength bands of waves, and a multi-task regression layer with dispersion constraints (Airy wave dispersion lambda_p = 0.1). The model was trained on an NVIDIA DGX A100 cluster and was early stopped at epoch 31 and achieved Pearson correlation coefficients of 0.451, 0.578, 0.643, 0.680 and 0.832 for Hs, Hmax, Tp, Tz and wave direction respectively, with generalization ability to geographically diverse held out test data sites. While operating in a data-limited regime (6 annotated training scenes), the framework demonstrates statistically significant temporal correlations (PCC of 0.451 to 0.832), confirming proof of concept feasibility; R2 values (max 0.246) indicate that variance capture will improve with larger annotated datasets.

Deep learning for EEG-based seizure detection faces critical challenges: severe annotation scarcity and extreme class imbalance, where ictal events comprise less than 10% of clinical recordings. We present DiffEEG, a 9.6M-parameter self-supervised foundation model that addresses both limitations through denoising diffusion pre-training and reinforcement learning (RL)-based fine-tuning. Pre-trained on 1.3M unlabeled segments from the Temple University Hospital Seizure Corpus (TUHSZ), DiffEEG learns generic neural representations via a 1D U-Net with multi-head self-attention. For downstream adaptation, a reinforced decision layer employs policy gradient optimization to directly maximize F1-score, prioritizing sensitivity to rare seizure events over overall accuracy. Under strict patient-wise evaluation (279 patients, Leave-One-Fold-Out), DiffEEG achieves 61% accuracy and 59% F1 for 4-class seizure subtyping, and 81% accuracy with 85% weighted F1 for binary detection, maintaining clinically viable seizure recall (59%) despite extreme imbalance (6.7% prevalence). Segment-level evaluation establishes an upper bound of 97.6% accuracy, confirming strong architectural capacity. DiffEEG demonstrates that diffusion-based pre-training combined with metric-aware reinforcement learning enables clinically deployable seizure monitoring with minimal labeled data requirements.

Breast cancer remains the most commonly diagnosed malignancy among women worldwide, yet accurate detection and characterization of breast masses in mammography remain challenging due to subtle intensity variations, heterogeneous tissue densities, and indistinct lesion boundaries that complicate radiological interpretation. To address these limitations, we propose BiLoG-Net, a deep learning framework that jointly performs breast mass segmentation and malignancy classification through bi-context location-aware feature modeling and segmentation-guided attention mechanisms. Our architecture integrates a novel encoder-decoder paradigm with Fire-based feature extraction, lightweight global and local feature enhancement modules, and adaptive location-aware gating to simultaneously capture long-range contextual dependencies and fine-grained boundary-sensitive details. Unlike conventional multi-stage pipelines, our tightly coupled multi-task design enables mutual reinforcement between pixel-level localization and image-level diagnosis, reducing error propagation while producing spatially grounded malignancy predictions. Evaluated on CBIS-DDSM and INBreast benchmarks, BiLoG-Net achieves state-of-the-art performance with Dice scores of 94.20% and 93.10%, classification accuracies of 95.20% and 93.60%, and AUC values of 97.10% and 96.00%, respectively, substantially outperforming existing CNN and transformer-based baselines. By combining precise boundary delineation with reliable malignancy assessment in a single end-to-end model, this work holds strong potential for clinical computer-aided detection systems, helping radiologists prioritize suspicious cases and improve screening efficiency in busy clinical settings.

Microbial density is clinically important for tumor assessment and treatment decision-making, and recent advances in deep learning suggest that it can be non-invasively inferred from multimodal MRI. In this work, MRI-based Microbial Density Stratification (MRI-MDS) is first investigated as a patient-level representation learning task, and Center Heatmap-driven Macro-micro modeling Network (CHM-Net) is introduced for this task. CHM-Net first establishes the link between imaging phenotypes and microbial states through center heatmap-guided small-lesion response localization. Building upon this, it constructs patient-level macro-micro evidence from localized heatmap responses for microbial density prediction. Experiments on the novel GBNPC 2026 dataset constructed for MRI-MDS demonstrate the effectiveness of CHM-Net, achieving superior performance over representative baselines with a 12.06% absolute ACC gain over the strongest competing result. Additionally, auxiliary validation on two 3D medical image datasets further verifies its robustness across volumetric medical image classification scenarios. The project is available at https://anonymous.4open.science/r/CHM-Net-942E/.

In many realistic scenarios, large volumes of time series data are generated with limited or expensive annotations. This limitation makes supervised learning methods difficult to apply and leads to the use of unsupervised approaches capable of discovering meaningful structures directly from raw data. Clustering therefore plays a crucial role in organizing time series into groups that share similar temporal patterns, enabling exploratory analysis and downstream tasks without requiring manual labeling. However, existing deep clustering methods often struggle to capture long-range temporal dependencies or rely on architectures with high computational cost. This paper introduces FMMVCC, a Mamba-based deep clustering framework for time series that leverages state space sequence modeling to efficiently learn temporal representations with linear complexity. Additionally, it utilizes multi-view self-supervised learning with temporal masking and augmentations. Experimental evaluation in 15 benchmark datasets proves that FMMVCC consistently outperforms state-of-the-art baselines, achieving the best overall performance in 29 of 60 total metric evaluations and the highest average rank in all tested scenarios.

The deep nonnegative matrix factorization (DNMF) technique is proposed to address the low interpretability of deep learning-based methods in extracting multilayer features from synthetic aperture radar (SAR) target samples. However, existing DNMF methods employ a layer-by-layer decomposition strategy, which is prone to causing error accumulation and local optimum, thereby hindering a consistent improvement in recognition accuracy as the number of layer increases. In this paper, a robust multilayer feature extraction method, termed generalized deep non-negative matrix factorization (G-DNMF), is proposed to address the above challenges in SAR automatic target recognition (ATR). The G-DNMF aims global optimality and derives the update rules for each parameter using lagrangian multiplier method. The new update formula indicates that both the DNMF method based on the encoding matrix and the mixing matrix are special cases of the proposed method, theoretically demonstrating the universality of proposed method. In general, the proposed method discards the layer-by-layer decomposition strategy, thereby effectively mitigating the risk of local optima and eliminating error accumulation, leading to a significant improvement in DNMF's multi-layer feature extraction capability. The experimental results, by presenting the feature images extracted from each layer by G-DNMF and the reconstructed original images, verified the proposed method's pure additive understanding of multi-layer features and demonstrated its interpretability. The experimental results based on MSTAR and OpenSARship datasets show that G-DNMF outperforms existing DNMF algorithms and their derivatives in terms of stability and recognition performance.

Deep learning applications have been widely adopted on edge devices, to mitigate the privacy and latency issues of accessing cloud servers. Deciding the number of neurons during the design of a deep neural network to maximize performance is not intuitive. Particularly, many application scenarios are real-time and have a strict latency constraint, while conventional neural network optimization methods do not directly change the temporal cost of model inference for latency-critical edge systems. In this work, we propose a latency-oriented neural network learning method to optimize models for high accuracy while fulfilling the latency constraint. For efficiency, we also introduce a universal hardware-customized latency predictor to optimize this procedure to learn a model that satisfies the latency constraint by only a one-shot training process. The experiment results reveal that, compared to state-of-the-art methods, our approach can well-fit the 'hard' latency constraint and achieve high accuracy. Under the same training settings as the original model and satisfying a 34 ms latency constraint on the ImageNet-100 dataset, we reduce GoogLeNet's latency from 40.32 ms to 34 ms with a 0.14% accuracy reduction on the NVIDIA Jetson Nano. When coupled with quantization, our method can be further improved to only 0.04% drop for GoogLeNet. On the NVIDIA Jetson TX2, we compress VGG-19 from 119.98 ms to 34 ms and even improve its accuracy by 0.5%, and we scale GoogLeNet up from 20.27 ms to 34 ms and achieve higher accuracy by 0.78%. We also open source this framework at https://github.com/ntuliuteam/ZeroBN

Automated detection of interictal epileptiform discharges in scalp electroencephalography (EEG) is clinically important, but recent high-performing deep-learning models often trade interpretability for accuracy. We introduce EEG-SpikeAgent, a closed-loop program-synthesis framework that uses a large language model (LLM) agentic system to generate signal-processing features for spike detection in scalp EEG. The system iteratively proposes one deterministic EEG feature module at a time, executes the resulting code on EEG to generate tabular features, evaluates performance via a tabular classifier, summarizes run-level metrics, and feeds structured diagnostics back to the model for refinement. Across iterations, EEG-SpikeAgent proposes and refines candidate signal features and decision rules informed by model performance. We evaluated EEG-SpikeAgent on VEPISET, a public 29-channel dataset of 4-second epochs containing 2,516 discharge-containing and 22,933 non-discharge epochs. Across five-fold cross-validation with a gradient-boosted tree classifier, agent-generated features achieved an area under the receiver operating characteristic curve of 0.935, balanced accuracy of 0.699, F1 score of 0.557, sensitivity of 0.401, and specificity of 0.996 at the default operating point. At an operating point with sensitivity 0.80, mean precision was 0.470 and mean specificity was 0.900. Artifact-aware feature generation improved balanced accuracy and F1 score over spike-only feature search. These results indicate that LLM-based program synthesis can automate EEG feature engineering in auditable and inspectable code-driven manner for clinical and methodological review.

Modernizing cancer registries with deep learning is opening new opportunities to automate labor-intensive tasks such as the coding of pathology reports. However, progress is constrained by the scarcity of report-level human-annotated training data. Cancer registries generate substantial volumes of expert-assigned labels as a routine product of their operations, but these exist at the patient level and are not linked to the individual pathology reports that informed them, limiting their direct use for training models. We develop an efficient framework for training deep learning classifiers by leveraging these operationally-generated labels without requiring per-report human annotation, demonstrated for tumor group classification at the BC Cancer Registry. We use Attention-Based Multiple Instance Learning (ABMIL) to recover the lost link between patient-level labels and the reports that informed them, leveraging the attention the model places on each report to distil a large, noisily-labeled corpus into a compact, high-quality per-report training dataset. A classifier fine-tuned on a distilled dataset achieved a macro F1 of 0.83, outperforming established baselines across most tumor groups. By turning routine operational labels into high-quality training data without additional annotation or large-scale computing infrastructure, ABMIL offers a practical and accessible route to automating cancer registry workflows.

Deep learning (DL) methods dominate thyroid nodule segmentation in ultrasound (US) images, achieving high Dice scores but at the cost of millions of parameters, GPU-dependent training via backpropagation, and limited mathematical tractability. These limitations impede deployment in resource-constrained environments. In this paper, we propose MedSaab-US, a backpropagation-free segmentation framework grounded in the Green Learning paradigm. MedSaab-US extracts multi-scale spatial-frequency features by combining multi-level Discrete Wavelet Transform (DWT) with multi-scale channel-wise Saab (Subspace Approximation with Adjusted Bias) transforms at patch sizes of 5 x 5, 11 x 11, and 21 x 21 pixels. Label-Assisted Greedy (LAG) feature selection retains the most discriminative features, which are fed to an XGBoost classifier for pixel-wise prediction. The Saab transform parameters are determined analytically from data statistics, while XGBoost employs iterative greedy tree construction without requiring backpropagation. Evaluated on the TN3K dataset (2,879 training and 614 test images), MedSaab-US achieves a mean Dice coefficient of 0.4784 +/- 0.2190, precision of 0.5768, and recall of 0.5604, with a model footprint under 500K parameters and CPU-only inference in approximately 0.3 seconds per image. We present this result as an exploratory non-DL baseline for thyroid ultrasound segmentation and analyze the specific challenges posed by isoechoic nodules. An ablation study further quantifies the contribution of each pipeline component, including separate evaluations of LAG feature selection and training-set size.

Prenatal anomaly classification and localization is of critical importance for fetal health and pregnancy management. Although ultrasound (US) is the primary modality for prenatal screening, accurate diagnosis remains challenging due to the low prevalence and high heterogeneity of anomalies. Existing deep learning methods for prenatal tasks rely on large-scale annotated datasets, which are difficult to obtain in practice. Although few-shot learning alleviates data scarcity, it typically requires fine-tuning for new categories, limiting its practicality in resource-limited clinical settings. To address these challenges, we propose a training-free framework for multi-class prenatal US anomaly classification and localization that operates with only a few reference images per class, representing the first exploration of this setting. Our framework comprises three key components: (1) a memory bank with multi-granular prototypes that explicitly models both class-level semantics and anomaly characteristics; (2) a prototype-driven soft merging mechanism that aggregates discriminative features to detect the anomaly region; and (3) a class-aware refinement strategy that leverages prototype consistency to improve category prediction. Extensively validated on a multi-center prenatal US dataset containing 1,149 cases, with a total of 2,357 images and 9 categories, our proposed method outperforms the competitors.

We investigate a forecasting framework based on a simple discrete-time dynamic model with coefficients varying in time. The parameters of the model are recovered within a deep learning framework, which makes it possible to retain a transparent parametric structure while simultaneously accounting for complex and nonstationary patterns in the observed phenomenon. Our analysis covers two specifications of the noise process. Besides the standard Gaussian setting, we also consider Laplace-distributed noise, which can offer a more adequate description in the presence of heavier tails and sharper local fluctuations. For both cases, we formulate the predictive scheme of the model and analyze the associated uncertainty quantification, including the construction of prediction intervals. The results illustrate that a relatively simple model, when combined with time-dependent parameter estimation, can serve as a mathematically tractable and practically flexible tool for forecasting complex dynamics under different noise assumptions. The general model is stated for TVAR($p$), while the prediction-interval formulas and the numerical experiments are developed for the TVAR(1) case.

Predicting complex spatiotemporal dynamics in physical processes often demands computationally expensive numerical methods or data-driven neural networks that suffer from high training costs, error accumulation, and limited generalizability to unseen parameters. An effective approach to address these challenges is leveraging physics priors in training neural networks, known as physics-informed deep learning (PiDL). In this work, we introduce the Multi-Resolution Finite-Volume-inspired network, MuRFiV, designed to capitalize on the conservative property of finite volume on the global scale and the expressive power of deep learning on the local scale. We demonstrate the effectiveness of MuRFiV on several spatio-temporal systems governed by partial differential equations (PDEs), including Burgers' equation, shallow water equations, and incompressible Navier-Stokes equations. By embedding PDE information into the deep learning architecture, MuRFiV achieves strong long-term prediction accuracy and remains stable over very long autoregressive rollouts, significantly outperforming data-driven neural network baselines. This result highlights the promise of combining multiresolution learning with finite-volume-inspired inductive bias for accurate and robust long-term prediction of complex dynamics.

Forest attributes are essential for national-scale resource monitoring. Airborne LiDAR metrics are among the auxiliary variables most strongly correlated with forest attributes used in National Forest Inventory (NFI) estimates. However, producing wall-to-wall predictions remains challenging when LiDAR data are acquired under heterogeneous conditions. As national LiDAR programs expand across Europe, variability in sensors, flight parameters, seasons, and scan angles limits the robustness of existing models, which are often calibrated for local conditions. We present FLORA (Forest LiDAR Octree Regression with Auxiliary Data), a deep learning framework that predicts six forest attributes: dominant height, total volume, deciduous volume, coniferous volume, basal area, and stem density from heterogeneous LiDAR point clouds. FLORA combines an octree-based backbone with ecological and spatiotemporal auxiliary variables through a late-fusion gating mechanism. Models are trained and evaluated on 32,052 National Forest Inventory plots across mainland France using data from the French LiDAR HD program. A single model trained on both leaf-on and leaf-off acquisitions outperforms season-specific models and improves cross-season robustness. Auxiliary variables provide modest overall gains but contribute more strongly to species-specific volume prediction. FLORA achieves an rRMSE of about 12.3% (R2 = 0.88) for dominant height and 39% (R2 = 0.74) for total volume, providing a robust baseline for large-scale forest attribute estimation from heterogeneous national LiDAR programs.

Developing a multi-level grading model for coronary artery stenosis holds great clinical significance for the diagnosis of coronary artery disease. However, designing an effective multi-level deep learning algorithm faces significant challenges. Specifically, utilizing CCTA or 3D SCPR images alone presents inherent shortcomings: CCTA images are difficult to analyze due to the tortuous paths of blood vessels, while 3D SCPR images are prone to abnormal distortions that hinder accurate grading. Furthermore, different stenosis grades are associated with varying clinical risks, and incorporating this association into the algorithm is non-trivial. To address the former problems, we propose the Curved Feature Reconstruction (CFR) module, which uses vessel curves as prior and employs a point-by-point correspondence strategy to precisely align and fuse features from both 3D SCPR and CCTA images. Meanwhile, a Clinical Risk-Aware (CR) Loss is employed to introduce clinical risk relevance into the network training so that the algorithm can better align with the clinical diagnosis. The experimental results on a in-house dataset reveal that our approach significantly outperforms other methods, and several ablation studies also demonstrate the effectiveness of our proposed designs.

With the rise of data-intensive science, algorithms have become central to scientific research. In academic papers, algorithms are mentioned for different purposes, such as describing, using, comparing, or improving methods for specific research tasks. Identifying these purposes can reveal relationships among algorithms and help assess their roles and value. Taking natural language processing (NLP) as an example, this study proposes a sentence-level framework for identifying, analyzing, and tracing the evolution of motivations for mentioning algorithms. We first identify algorithm entities and algorithm-related sentences from full-text papers through manual annotation and machine learning. We then classify mention motivations using pretrained models and data augmentation, and analyze their distribution and temporal evolution. The results show that deep learning models trained with augmented data outperform traditional machine learning models in motivation classification. In NLP papers, more than half of algorithm-related sentences express direct use, whereas improvement is the least frequent motivation. The diversity of motivations has increased over time. For specific algorithm categories, grammar-based algorithms are more often mentioned for description, while machine learning algorithms are more often mentioned for use. Over time, use motivations have gradually replaced description motivations across different algorithms, and the number of motivation types associated with individual algorithms has declined significantly. This study reveals how authors mention algorithm entities in academic writing and provides a basis for future research on algorithm relationship identification and algorithm impact evaluation.

Topological data analysis (TDA), particularly persistent homology (PH), captures geometric structural properties in medical images (e.g., connected components, loops, shape characteristics), which conventional pixel-level deep learning approaches often neglect. While many topological descriptors are known for converting persistence diagrams (PDs) or raw images into topological feature vectors, existing methods mostly default to a single fixed descriptor (e.g., persistence images), leaving the diversity of topological representations largely unexplored. To the best of our knowledge, there is no known large language model (LLM)-based agentic framework that can automatically determine the most suitable topological descriptors for a given image dataset and produce the corresponding topological feature vectors for downstream tasks. To fill this gap, we propose \textbf{TopoAgent}, an LLM-based agentic framework that automates topology learning for medical image analysis.TopoAgent operates through a Perception--Reasoning--Action--Reflection loop supported by 21 domain-specific tools and dual memory that accumulates experience across runs. Its skill set is distilled from systematic evaluation of 15 topological descriptors across 26 datasets with six classifiers. TopoAgent analyzes input images and their topological characteristics, reasons about which topological descriptors best suit the input, and determines the optimal descriptor and its configuration, all without task-specific training.

Post-hurricane damage assessment and repair scheduling can require computationally intensive simulation and optimization. This paper presents an integrated two-stage deep-learning tool for rapid damaged-line identification and repair-schedule computation. An available offline synthetic dataset for the IEEE 9500-node test feeder contains 1,700 hurricane scenarios with exposure features, grid metadata, fragility parameters, OpenDSS outputs, damaged-line labels, and Adaptive Large Neighborhood Search reference schedules. Stage 1 benchmarks MLP, ResMLP, and GraphSAGE, while Stage 2 compares MLP, DeepSets, and Set Transformer. The selected ResMLP-Set Transformer pipeline propagates Stage 1 errors into Stage 2 and achieves a damaged-job F1-score of 0.920, pairwise order agreement of 0.854, and start- and end-time mean absolute errors of 4.349 min and 4.486 min, respectively. The tool provides rapid initial repair-log decision support for new hurricane cases.

Change Detection (CD) aims to identify semantic or structural changes from nearly registered multi-temporal images. While recent advances in training methodologies have largely focused on semi-supervised learning and consistency regularization, alternative training paradigms remain underexplored. In particular, most deep CD methods rely on uniform sampling during training, implicitly assuming that all training samples contribute equally to the optimization process. However, such naive sampling can introduce noisy gradients and hinder robust representation learning. To address this limitation, we propose a curriculum learning framework tailored for change detection. Our approach investigates two complementary difficulty measures: the Solar Angular Gap (SAG), a physically grounded proxy for acquisition-condition variability, and the Structural Similarity Index Measure (SSIM), which evaluates appearance similarity between image pairs. Based on these criteria, the framework progressively introduces challenging samples during training, enabling models to learn robust representations in a coarse-to-fine manner. We evaluate our method on the challenging SeracFallDet benchmark, where results demonstrate consistent improvements of the proposed approach over standard uniform-sampling strategies for both pixel-based and object-based approaches. These results highlight the potential of curriculum learning to improve robustness in deep change detection. Importantly, our training framework is orthogonal to existing CD architectures, making it readily applicable to a broad range of methods.

The efficiency of high-power laser systems is limited by wavefront distortions in the beam, particularly non-common path aberrations, which reduce the peak intensity at the focal plane. Compensating for these aberrations requires the calibration of the adaptive optics system. Conventional calibration methods rely on a time-consuming iterative optimization that is highly sensitive to initial conditions. While deep learning-based models offer high speed, they often demonstrate insufficient accuracy. In this work, we present a hybrid wavefront reconstruction method that combines a convolutional neural network to generate an initial estimate of the wavefront distortions, with the L-BFGS (Limited-memory Broyden-Fletcher-Goldfarb-Shanno) algorithm for its subsequent refinement. In numerical simulations, the method achieved an efficiency of $\sim 0.99$ in 80% of the cases for a root-mean-square (RMS) of wavefront distortions ranging from 0 to $1.3λ$. In a physical experiment, for initial wavefront distortions with RMS values from 0.15 to $0.6λ$, the method achieved an efficiency of $\sim 0.75$. As a result, focusing with a Strehl ratio of $0.96 \pm 0.02$ was attained within 2 to 4 iterations of the algorithm, confirming the applicability of the method for the fast and accurate calibration of adaptive optics systems under real experimental conditions.

High-dimensional partial differential equations (PDEs) with unknown coefficients arise widely in scientific machine learning, including continuous-time reinforcement learning, yet solving them efficiently in a data-driven way remains challenging. Existing deep learning solvers often rely on repeated automatic differentiation to evaluate differential operators, which can cause instability and amplify derivative errors in high dimensions, while probabilistic methods based on stochastic representations require explicit knowledge of the data-generating dynamics and therefore do not apply to black-box environments. We introduce two types of simulators as data-generating mechanisms, and take a ``representing-then-learning" approach that learns the solutions and their derivatives under settings where the underlying PDE operators are accessible only through simulations and pointwise evaluations. Our representation of derivatives relies on the zeroth-order derivative (ZOD) estimators derived from perturbed Monte Carlo trajectories. This fully model-free approach generates targets for the gradient and Hessian networks using only function evaluations. We provide a statistical learning analysis of the proposed approach, including a bias--variance tradeoff for ZODs. Assuming a standard contraction property of the underlying operator, we establish a non-asymptotic error bound that decomposes the total error into discretization error, approximation error, statistical error, and ZOD bias. Crucially, we derive the sample complexity of the learned representations in (weighted) Sobolev space, characterizing the error up to second-order derivatives. Numerical experiments illustrate the competitive performance of the method in moderate and high dimensions.

Lip-syncing deepfakes are among the most challenging forms of manipulated media because their artifacts are localized almost exclusively to the mouth region and evolve dynamically over time. Detecting such deepfakes requires precise temporal and spatial modeling of lip motion. In this paper, we propose LoCC, a novel detection framework that performs fine-grained detection and localization of lip-syncing deepfakes at both segment and frame levels. Unlike prior approaches that analyze videos holistically, our method evaluates whether each frame aligns with a counterfactual estimate generated from its temporal neighbors. Real videos exhibit strong and stable consistency, whereas lip-sync deepfakes introduce localized inconsistencies. Following a teacher-student learning paradigm, our model effectively captures these frame-level discrepancies and achieves superior performance over state-of-the-art methods on multiple benchmark lip-syncing deepfake datasets, including LAV-DF, AVDF1M, FakeAVCeleb, and KODF, and generalizes well across compression levels and datasets.

Sexual identification of decomposed cadavers challenges traditional methods dependent on visual anthropological analysis. This study evaluates state-of-the-art deep learning (including YOLO26, YOLO11, ConvNeXt-Tiny, EfficientNetV2, ViT-B16, VGG16, and ResNet50) with transfer learning to automatically determine biological sex from forensic computed tomography (CT) scans. We analyzed 141 autopsied cadavers from the Forensic Medical Institute of Goiânia-GO, including a broad age range and varying conditions of preservation. The three-dimensional reconstructions of the pelvis and skull were converted into standardized two-dimensional profile projections, contributing to the study of this new technical approach. Data augmentation techniques compensated for sample limitations. Two scenarios were validated: binary and quaternary classification (one class per sex vs. one class per anatomical region of each sex). The best-performing model achieved highly consistent results on the pelvis region and still satisfactory performance on the skull region, reaching an overall patient-level accuracy of 95.65%, recall of 92.86%, F1- score of 94.36%, and precision of 97.22%, maintaining consistent performance across the evaluated cases, including those with trauma-related artifacts. Results indicate the technical feasibility of the methodology, demonstrating that deep learning models can provide objective, high-speed skeletal analysis. Since the study was conducted using data from a single institution and a single computed tomography scanner, further validation across multiple centers and scanners is required to assess the generalizability of the proposed approach

Accurate prediction of repair duration is an important challenge in product maintenance due to its implications for resource allocation, customer satisfaction, and operational performance. This study aims to develop a deep learning framework to help fleet repair shops accurately categorize repair time given product historical data. The study uses an automobile repair and maintenance dataset and creates an end-to-end predictive framework by employing a multi-head attention network designed for tabular data. The developed framework combines categorical information, transformed through embeddings and attention mechanisms, with numerical historical data to facilitate integration and learning from diverse data features. A weighted loss function is introduced to overcome class imbalance issues in large datasets. Moreover, an online learning strategy is used for continuous incremental model updates to maintain predictive accuracy in evolving operational environments. Our empirical findings demonstrate that the multi-head attention mechanism extracts meaningful interactions between vehicle identifiers and repair types compared to a feed-forward neural network and a random forest model. Also, combining historical maintenance data with an online learning strategy facilitates real-time adjustments to changing patterns and increases the model's predictive performance on new data. The model is tested on real-world repair data spanning 2013 to 2020 and achieves an accuracy of 78%, with attention weight analyses illustrating feature interactions.

Detecting the tiny Doppler shifts induced by Earth-mass planets in stellar radial-velocity measurements remains extremely challenging due to stellar activity. Many deep-learning methods performing well on simulated data remain difficult to apply reliably on real stellar spectra. The aim of this work is to develop a deep-learning framework that generalizes to real, unseen spectra and improves the detectability of Earth-mass planets in radial-velocity data. We train artificial neural networks on HARPS-N solar spectra with injected planetary signals, using physics-motivated spectral representations based on flux and line-formation temperature, together with their velocity gradients. Two training strategies are explored: hold-out testing and cross-validation. Model robustness is enhanced through genetic-algorithm-based hyperparameter optimization, and predictive uncertainty is quantified using Monte Carlo dropout. Our most precise neural network model reliably retrieves, under the cross-validation strategy, the amplitudes, phases, and orbital periods of planetary signals with amplitudes greater than or equal to 25 cm/s and periods between 10 and 550 days. In addition, in all cases tested here, the successfully recovered signals correspond to the most significant peaks in the periodograms of the Doppler-shift predictions. Temperature-based spectral-shell representations consistently outperform flux-based shells. We also release doppleriann, a Python package implementing the proposed framework. Our results demonstrate that combining physically motivated spectral representations with deep learning provides a promising pathway toward the detection of Earth-mass planets in radial-velocity data from real observations, supported by a modeling framework that is both physically grounded and statistically rigorous, incorporating uncertainty quantification and optimized training strategies.

This study proposes an overall deep learning architecture for multi-class classification of plant diseases from high-resolution leaf imagery, with a particular interest in investigating the behavior of ResNet-50 and a hybrid ResNet + Vision Transformer (ViT) design. A specially gathered image database with 15,200 training images and 3,800 validation images spanning 38 classes across multiple crops, including tomato, apple, grape etc. were subjected to preprocessing steps such as resizing, normalization, and data augmentation to enhance model robustness. Multiple architectures, including ResNet-50, MobileNetV2, and EfficientNet-B0, were trained and compared with the hybrid ResNet + ViT model. All models were fine-tuned using the AdamW optimizer and cross-entropy loss, with early stopping applied to prevent overfitting and ensure generalization. Furthermore, interpretability techniques such as Grad-CAM and saliency maps were implemented to indicate disease-relevant regions, while segmentation-based analysis was performed to identify the affected parts of a leaf. For every one of the considered architectures, ResNet-50 led to the highest accuracy of 98.74%, whereas the hybrid ResNet + ViT model achieved a competitive accuracy of 98.58%, showing that the hybrid architectures were effective in capturing both local and overall information. The experimental results showcase the promise of transformer-based models to achieve highly accurate, interpretable, and computationally efficient computer-based multi-class multi-disease classification systems, providing helpful assistance for cultivation management practices as well as for precision farming.

Early detection of plant diseases is crucial to plants and for the farmers. Plant diseases reduce fruit yield and quality, and plants are more susceptible to other stresses when they are infected. The lemon leaf disease dataset contains 1354 images. The dataset has 9 classes. Among the 9 classes only one class is for healthy leaf, and the other 8 classes are leaf diseases. The dataset was split into training (70%), testing (15%) and validation (15%) sets after comprehensive preprocessing. Two pretrained models (InceptionV3 and MobileNetV2) were applied and then combined these models using an ensemble technique to boost robustness. Ensemble models showed a promising performance of 99.27% accuracy. Adversarial Training is applied to improve models' ability and ensure reliable predictions under noisy data. Grad-CAM visualization highlights the important regions of leaf images that validate the model prediction with confidence level.

Automated aerial wildlife surveys increasingly rely on deep learning, yet standard object detectors require bounding-box annotations, reported to be up to seven times slower and three times more expensive to produce than point-level labels. To address this bottleneck, we introduce the Overhead Wildlife Locator (OWL), a weakly supervised density-estimation framework with three variants: OWL-C, a fully convolutional model for high-throughput screening; OWL-T, a Swin-augmented hybrid for heterogeneous, cluttered scenes; and OWL-D, built on a frozen DINOv3 ViT-H+/16 encoder with a DPT-style fusion decoder. We benchmark all three against POLO, YOLOv11n, and YOLOv11l across five public aerial datasets, from sparse fixed-wing savanna surveys to dense UAV paddock imagery, and against the published HerdNet baseline on its native Delplanque split. OWL-D sets a new state of the art on Delplanque (0.934 AP vs. HerdNet's 0.840) and records the highest AP on four of the five datasets. Performance is regime-dependent: on the extreme-density SheepCounter UAV dataset the hybrid OWL-T leads (0.978 AP) and the convolutional variants attain the lowest counting error, whereas the foundation-based OWL-D degrades, indicating which variant suits which survey type. We further validate operational readiness on the Alaska Department of Fish and Game's 2022 Central Arctic Caribou census: under cross-herd and cross-temporal transfer, OWL-C fine-tuned on the 2017 Porcupine Caribou Herd split attains F1 = 0.965 on a held-out patch test set, with a signed count error of +3.1% aggregated across the released test patches. We release the OWL code, model weights, and the annotated Porcupine Caribou Herd 2017 (PCH) and Central Arctic Herd 2022 (CAH) patches, the first open patch-level datasets for large-scale caribou aerial surveys, at https://github.com/microsoft/MegaDetector-Overhead.