Digital Twins

Head-and-neck (HN) proton therapy is highly sensitive to anatomical change over a 4-to-6-week course, as tumor shrinkage, weight loss, and setup variation can misposition the Bragg peak near critical organs such as the parotids, oral cavity, brainstem, and spinal cord, leading to target underdosing or organ-at-risk overdosing. Online adaptive proton therapy replans on the anatomy of the day, yet standard workflows rely on offline replanning that requires repeated CT acquisition and roughly a week of preparation, adding burden, cost, and delay. We investigate whether a patient's treatment-day anatomy can be predicted before image acquisition by transferring longitudinal change from a population database. We propose a digital-twin framework built on a pretrained foundation-model deformable registration network used without patient-specific training. A first registration aligns a prior patient's planning CT to the target and carries the prior's during-treatment quality assurance CT (QACT) into the target frame; a second registration estimates the prior's planning-to-QACT change, which is then applied to the target's own planning CT to synthesize predicted CTs (pdCTs) with propagated contours. Using 88 HN patients, each with a planning CT and three QACTs, we show that pdCTs better match treatment-day anatomy than the static planning CT. Compared with the planning CT alone, normalized cross-correlation improves by 22.8%, Dice for organs-at-risk by 20.2%, and CT-number error decreases by 23.4%. Gains are largest for patients with major anatomical change and negligible when anatomy is stable. This cross-patient motion transfer leverages the digital-twin concept to anticipate treatment-day anatomy, enabling personalized online adaptive proton therapy without repeated imaging.

ORCESTRA is a mixed-reality system for programming robot digital twins through no-code waypoint teaching and language-guided control. In a passthrough mixed-reality workspace, users place robot twins on real surfaces, teach trajectories, save robot-relative episodes, or issue spoken/typed commands that a vision-language model converts into structured digital-twin plans. Both interaction modes share a backend for metric grounding, embodiment-aware validation, preview, confirmation, and digital-twin execution. The system supports heterogeneous robot embodiments, including fixed-base manipulators, a mobile base, and a humanoid robot, demonstrating MR validation as a safety layer for language-guided robot programming before physical deployment.

Indoor mmWave radar perception is difficult to reproduce because measured range-angle responses depend on scene geometry, material response, multipath, hardware conventions, and signal processing. Existing ray-tracing and digital-twin tools often expose rendering, channel, or path-level quantities, while radar sensing requires complex signal products that can be processed and compared in the same domain as real FMCW measurements. We present mmRadarTwin, a signal-level and path-attributed digital-twin platform for indoor mmWave radar. mmRadarTwin links a real radar measurement branch with an Unreal Engine scene-simulation branch through a shared receive-channel and range-angle processing interface. The simulator writes complex multi-channel receive grids and exports per-path contribution records that identify the actor, material tag, propagation event, and output-bin support of each simulated return. We evaluate mmRadarTwin in an office deployment using a commodity monostatic mmWave radar and mobile scene-capture hardware. Across 154 measured poses spanning 22 radar locations, the current physics-only path-basis simulator recalls 70.8% of measurement-active geometry-supported response regions in the central usable field of view while exposing residuals caused by weak or missing path support, shifted responses, unsupported anchors, and missing physical mechanisms. Rather than claiming complete radar-map reconstruction or cross-room generalization, mmRadarTwin establishes a practical systems workflow for constructing, comparing, and diagnosing indoor radar digital twins.

Building interactive digital twins requires recovering both 3D geometry and the kinematic structures that govern how objects articulate. Yet existing methods for articulated object reconstruction require explicitly observable motion from multiple articulation states. We introduce a rest-state formulation that reconstructs articulated objects from a single closed configuration, an inherently ill-posed setting where geometry, semantics, and motion priors compensate for the absence of motion cues. Our framework adopts an explicit mesh as an intermediate representation for cross-model verification and fusion, reconciling noisy outputs from vision-language and segmentation models into spatially consistent part structures. To estimate joint parameters without observed motion, we use a video diffusion model to synthesize articulation hypotheses and validate them through geometric consistency. Our approach achieves accurate part decomposition and physically plausible articulation, performing competitively with motion-observing reconstruction-based, generation-based, and modular pretrained-model baselines.

Digital twins have emerged as a foundational technology within the context of Industry 4.0, offering a paradigm for the real-time virtual representation of physical systems. However, managing their growing complexity, particularly in distributed industrial environments, requires intelligent architectures capable of autonomous decision-making, dynamic adaptability, and inter-agent coordination. This systematic review explores the intersection between Multi-Agent Systems and Digital Twins, with a particular focus on predictive maintenance applications in resource-constrained contexts. Through a critical analysis of over 547 papers published in high-impact journals (IEEE Transactions, Nature, Elsevier, MDPI), we establish a taxonomy of existing hybrid architectures, identify persistent technological bottlenecks, and formulate three open research questions concerning: (i) the deployment of artificial intelligence on resource-constrained microcontrollers, (ii) distributed multi-node coordination via lightweight communication protocols, and (iii) the hierarchical orchestration of Digital Twins toward smart factory control integrating residual life estimation and explainable Artificial Intelligence. The results of this analysis reveal that, despite significant progress, no existing system offers an integrated embedded-distributed hierarchical solution that simultaneously meets the requirements of Industry 5.0.

Mobile-health interventions increasingly use online learning and decision making algorithms to personalize when to nudge users toward healthier behavior, but a poorly designed algorithm can burden and disengage participants. New algorithm design decisions should therefore be vetted against realistic simulated users before each real-life deployment. We propose a method to develop ``JITAI-Twins'': digital twins of a target subpopulation for comparing candidate online algorithms before a just-in-time adaptive intervention (JITAI) deployment. The method builds on a conditional time-series diffusion model that is temporally consistent (future actions do not affect the generated past), and it supports repeated updating from three sources of information, in three steps: pre-training on a large observational dataset, fine-tuning on small prior intervention deployments in related populations, and inference-time calibration to the next target population from domain-scientist expertise. We validate the twin at each pre-deployment stage of the long-running HeartSteps series (v2 through v4) of physical-activity suggestion intervention deployments, treating each successive deployment as an upcoming study. The proposed method reproduces the target subpopulation's temporal and between-participant structure better than simpler simulators. These results suggest that our twin can be used to simulate a target deployment before it runs, the prerequisite for testing and informing online algorithm design decisions.

Digital twins are often used to predict how a system would respond to an intervention. In systems with feedback, a twin must reproduce an equilibrium counterfactual, and a twin developed in one domain may fail after mechanisms change. We study when these predictions can be validated and transported. For equilibrium causal games, we give conditions on the mechanisms, equilibrium selection, and intervention design under which agreement with experimental distributions identifies the counterfactual of interest. We show why agreement of means and covariances is insufficient for distributional queries. We then introduce cyclic selection diagrams and derive criteria for direct reuse and for hybrid models that combine invariant source mechanisms with target information. An impossibility result constructs systems that agree under every experiment in a finite design but disagree on the target counterfactual, showing that validation requires structural assumptions. For linear models, we derive intervention requirements that depend on the mechanisms that changed, the observation model, and graph support. When point identification fails, we characterize the remaining range of query values. We also provide statistical tests for reconstructed means and covariances and illustrate the theory in synthetic feedback systems.

Smartphone personal assistants reason over longitudinal personal data, yet evaluating them requires context-rich evaluation data whose correct answers are known, and real device traces are too privacy-sensitive to share. To address this challenge, we present SenWorld, a physically grounded, deterministic, event-sourced digital-twin simulation that generates such data with ground truth fixed by construction. In SenWorld, personas live through a full day in a world built from real map, weather, holiday, and network data; every observable signal is archived in full-system snapshots; and each evaluation case is labeled by a pointer to an existing record rather than by post-hoc annotation or a large language model (LLM) judge. We evaluate this method with 16 personas in Beijing. The generated data closely matches the held-out real-user benchmark in category distribution (Jensen--Shannon divergence (JSD) 0.070) and in the daily rhythm of communication records (JSD below 0.1), though generated records remain shorter than real ones. Without scripted interaction, personas form a fully reciprocated dialogue subgraph and differentiated behavioral repertoires. Projected into 717 evaluation cases, the generated data exposes 78 failures in a production smartphone assistant, concentrating on call and Short Message Service (SMS) records while contacts, schedules, and alarms never fail. The snapshot pointer confirms each failure as an assistant-side retrieval error, with no LLM judge involved. Overall, SenWorld offers a privacy-safe, reproducible, and distribution-checked path to evaluation data whose labels are fixed by construction.

In efforts to increase research efficiency and availability, a digital twin of our research tractor (AMX G-trac) is created, focusing especially on the CAN communication for data reading and actuation command following the ISOBUS protocol. Mevea Simulation Software is utilized as the foundation, providing the kinematic model and visuals, while Python is used to read and write CAN messages over a Kvaser CanKing virtual CAN channel. Various performance tests involving straight line and turning behavior are performed in both the digital twin simulation and in the real world to measure similarity. Results indicate that the Mevea model behaves very comparable in its lateral dynamics, often within 5-10 percent, but requires better data to fully capture the longitudinal aspects like acceleration. The final model described in this paper sets the table for a second iteration to include more tractor functions such as hydraulics and tractor-implement dynamics.

Digital Twins rely on surrogate models to mirror physical systems in real time, yet these models can degrade as operating conditions evolve, a phenomenon known as concept drift. Maintaining surrogate fidelity under drift, particularly when models must also capture aleatoric uncertainty, remains an open challenge. Existing adaptive frameworks lack principled mechanisms for detecting when updates are needed, for efficiently adapting models from limited streaming data, and for certifying that updates genuinely improve predictive performance. Here we present an adaptive Digital Twin framework that integrates a Fisher score--based multivariate drift detector, Low-Rank Adaptation (LoRA) for parameter-efficient continual learning, and a Mann--Whitney $U$ test for online statistical validation. The framework monitors surrogate-model confidence via Fisher score vectors, triggers targeted fine-tuning of fewer than 1% of model parameters upon drift detection, and statistically certifies predictive improvement before deploying the updated surrogate. Applied to a stochastic linear system and a directed energy deposition additive manufacturing process as case studies, the framework successfully detects distributional shifts with short delays and restores both predictive accuracy and uncertainty quantification under abrupt and incremental drift. These results establish a statistically rigorous and computationally tractable pathway for sustaining the trustworthiness of neural-network--based Digital Twins throughout their operational life cycle.

This work addresses the need for engineering-grounded evaluation of implement-ed tariff mechanisms in distribution-level energy systems. A digital twin-based method is proposed for assessing local collective tariffs under realistic behavioral and infrastructural conditions. The approach integrates agent-based modeling of household consumption and generation, virtual aggregation through a shared metering abstraction, and explicit representation of tariff logic within a unified simulation environment. The method is demonstrated through its application to the Danish Local Collective Tariff across representative residential energy community configurations, including scenarios with photovoltaic generation, battery storage, and electric vehicle charging. Results indicate that aggregation of heterogeneous demand profiles reduces peak coincidence and enables more efficient allocation of tariff components, leading to measurable cost reductions at the community level. At the same time, the outcomes reveal sensitivity to the temporal alignment of consumption and generation, influencing the degree of cost neutrality across participants. The findings illustrate how digital twin-based evaluation can support systematic assessment of tariff mechanisms by capturing the interaction between infrastructure, user behavior, and regulatory design. The proposed approach provides a basis for analyzing and comparing tariff structures in distribution-level energy systems beyond the specific case considered.

Digital twins enable robots to anticipate and adapt to physical interactions, but existing models struggle with elastoplastic articulated objects (EAOs) that exhibit nonlinear elasticity, plastic yielding, and damage accumulation. We present BoxTwin, an interactive digital twin framework that learns the full dynamics of EAOs from videos. Our pipeline reconstructs the scene, identifies a physics aware constitutive model for each EAO. Experiments on manual folding and dual arm manipulation of EAOs show that BoxTwin accurately tracks joint trajectories and reproduces post contact plastic behavior over long horizons. By integrating video driven reconstruction with elastoplastic damage modeling, BoxTwin advances digital twins toward predictive, adaptive control of deformable articulated objects in unstructured environments.

The rapid digitalisation of elite sport has created new opportunities for integrating artificial intelligence (AI), performance analytics, and decision-support systems into athlete development and competition management. However, existing solutions remain fragmented, typically addressing isolated tasks such as performance analysis, athlete monitoring, or referee support. This paper presents \textbf{FST$\cdot$ai2.5}, an explainable, uncertainty-aware, and secure AI framework for Olympic and Para-Taekwondo. \textbf{FST$\cdot$ai2.5} introduces a unified digital ecosystem integrating athlete intelligence, competition analytics, federation-scale data management, AI-assisted decision support, athlete and event digital twins, explainable performance indicators, and adaptive training recommendations. The framework supports World Taekwondo (WT), Member National Associations (MNAs), coaches, referees, analysts, and athletes through transparent, secure, and federation-aware governance. By combining multi-source competition data, athlete-performance information, and contextual evidence, \textbf{FST$\cdot$ai~2.5} provides tactical diagnostics, longitudinal athlete monitoring, performance forecasting, personalised development planning, and federation-wide benchmarking using explainable and uncertainty-aware AI. Prototype deployments demonstrate the feasibility of the proposed framework. Although developed for Olympic and Para-Taekwondo, the methodology is broadly applicable to explainable AI, digital twins, and trustworthy decision support in combat sports and other high-performance sporting environments.

High-fidelity simulation of mmWave radar signals for dynamic human motion is valuable for developing radar-based human sensing models; yet collecting accurately labeled measurements for a specific deployment site remains expensive. We present HybridSim, a physics-learning hybrid simulator that synthesizes mmWave radar signals from dynamic human meshes under a fixed indoor room configuration, explicitly decoupling propagation into two components. To parameterize the human subject, we use a tri-plane representation to extract human features and a Graph Convolutional Network to stabilize optimization and mitigate gradient instability. The direct signal path is modeled via an inverse-rendering formulation with a microfacet BRDF to capture primary surface reflections. In parallel, the indirect path is approximated by combining 3D Gaussian Splatting with a virtual-receiver geometry to fit and reproduce site-specific multipath interference patterns, achieving substantially lower computational cost than explicit full ray tracing. Experiments in a fixed-room setting show improved agreement with a physically based reference and consistent gains on downstream radar-based human sensing tasks when using HybridSim for site-specific data augmentation.

Brain tumor progression exhibits spatially heterogeneous growth, patient-specific treatment response, and complex interactions with surrounding anatomy, making accurate long-term prediction challenging. We propose an AI-augmented adaptive digital twin (DT) framework for brain tumor evolution prediction and treatment scheduling. The framework integrates an interpretable reaction--diffusion (RD) model, a 3D residual learning module for model-form correction, patient-specific DT updating during recursive rollout, and model predictive control (MPC) for constrained chemotherapy and radiotherapy scheduling. Experiments on 387 synthetic tumor trajectories with 120-step evolution show that the baseline RD model captures tumor location and overall temporal behavior but underestimates heterogeneous tumor burden during long-horizon prediction. Hybrid RD--residual modeling reduces masked voxel-wise mean squared error by 84.3% and increases Dice overlap by 43.5% relative to the RD baseline under dense simulated observations. Online DT updating further reduces mean squared error by 45.9% and improves Dice overlap by 9.6% compared with the non-updated hybrid model. In MPC-based scheduling simulations, the updated DT controller reduces final tumor burden by 22.4% relative to a fixed treatment schedule under the terminal-burden objective. Together, these results demonstrate a unified framework for patient-specific initialization, mechanistic modeling, adaptive learning, and constrained treatment optimization. Although validated using patient-data-informed synthetic trajectories rather than clinical longitudinal data, the proposed framework establishes a foundation for future translation to real-world adaptive treatment planning.

European safety regulation now permits a large share of automated-driving homologation evidence to be produced virtually, provided a validated physical-virtual facility generates it. We present a deployed hybrid Vehicle-in-the-Loop (ViL) platform that couples a real instrumented vehicle with a CARLA-based digital twin (DT) through a V2X message pipeline, and we report its first integrated operation on a public-road-representative test track. A real vehicle streams ETSI-compliant CAM/CPM messages into the DT, where a GPU-accelerated Cooperative Perception (CP) module fuses them into a probabilistic occupancy grid during scenario runtime. We demonstrate the platform on a multi-vehicle double T-intersection scenario, characterise the CP workload across nominal, rain and night conditions and five localization-noise levels, and discuss the platform's current architectural limits and the engineering targets they define. The results show that CP substantially widens field-of-view (FoV) coverage and improves occupied-cell recall, and that beyond a moderate localization-noise threshold, positioning uncertainty, and not weather, becomes the dominant error source. We outline the platform's trajectory toward a Mediterranean operational design domain (ODD) testing service.

This book chapter covers the evolution of social simulation from classical agent-based models, in which agents interact according to explicitly defined behavioral rules, to AI-enhanced simulations based on Large Language Models and, ultimately, Social Digital Twins: high-fidelity, data-driven representations of real-world socio-technical systems. Along this trajectory, we discuss the main methodological foundations, applications, advantages, and limitations of each paradigm, highlighting the progressive shift from abstract models designed to investigate general social mechanisms toward increasingly realistic computational representations of specific social systems.

Existing approaches to infer user traits and generate responses consistent with a persona rely on static prompting. They lack calibrated uncertainty, ignore sequential evidence, and drift during long interactions. We present AI YOU, a framework that continually updates a personality profile with 22 dimensions from conversation and embodies it in a personal digital twin. Practically, the system combines prompting, Bayesian updating, and conformal prediction for persona inference. A periodically refreshed memory anchor and cognitive memory with three layers preserve persona consistency over long interactions. Across the main results, AI YOU (i) achieves conformal coverage ranging from 0.921 to 0.976, (ii) improves uncertainty calibration and reasoning grounded in memory, and (iii) enhances persona fidelity over static prompting in role playing over 100 turns while reducing trait drift, for most evaluated backbones under adversarial settings with multiple agents. The prototype AI YOU Town initializes an imaginative twin world for future interaction. The online demo is available at \href{https://quinnnnnne-ai-you.hf.space/}{\mbox{`quinnnnnne-ai-you.hf.space`}}.

Embodied agent teams powered by heterogeneous large language models (LLMs) are being widely deployed in physical artificial intelligence such as smart factories, warehouses, and service robotics. To enable collaboration among such an agent team, efficient coordination mechanisms that operate reliably under limited network resources are required. However, existing heterogeneous LLM-agent coordination frameworks that rely on multi-round natural-language-based conversations introduce three coupled challenges. First, inter-agent dialogue incurs communication overhead that grows rapidly with team size. Second, the quality of coordination is constrained by the heterogeneous capabilities of the agent team's LLMs. Third, agents may suffer from action delays due to iterative negotiation. To address these challenges, we propose LDT-Coord, a networked coordination framework built upon a lightweight digital twin (DT). Specifically, each agent independently selects its intended action and reports both the action decision and a structured temporal constraint over shared resources to the DT server, thereby decoupling coordination performance from natural-language reasoning ability. Then, DT executes a training-free, rule-based orchestrator algorithm to resolve cross-agent conflicts and returns coordination instructions to prevent such conflicts. To further reduce communication overhead, we formulate agent reporting control as a constrained partially observable Markov decision process (C-POMDP) and solve it with the PPO-Lagrangian algorithm. Simulation results show that LDT-Coord achieves a task success rate comparable to conventional coordination methods while reducing communication overhead by more than 70x and maintaining robustness under LLM heterogeneity.

Customer behavior modeling underpins recommendation, marketing, and decision support, yet existing approaches either optimize predictive accuracy without explaining decisions or simulate users without grounding them in real behavioral data. We present the Large Behavioral Model (LBM) that learns customer decision making directly from large-scale retail transactions through a unified Person-Environment formulation. Customer state is represented by a behavioral profile derived from historical purchases, while product context is incorporated through retrieval-augmented generation. The model is trained using continued pre-training on verbalized behavioral data, supervised fine-tuning for decision generation, and reinforcement learning with verifiable rewards for evidence-based calibration. We evaluate the proposed framework on purchase prediction, hard-negative discrimination, basket completion, promotion response, and cross-domain voucher redemption. The model consistently outperforms frontier general-purpose language models on in-domain retail tasks while demonstrating strong zero-shot and fine-tuned transfer across retailers and decision domains. Ablation studies show that continued pre-training is the primary driver of behavioral generalization, retrieval is most effective when applied during both training and inference, and reinforcement learning improves reliance on explicit behavioral evidence over generic language-model priors. These results demonstrate that behavioral knowledge encoded in transaction histories can be effectively learned by language models, providing a scalable foundation for customer digital twins and behavior simulation.

Humans can navigate an unfamiliar city and gradually form a coherent spatial mental map spanning tens of square kilometers. Can AI build spatial representations at a comparable scale? Although recent foundation models have advanced scene reconstruction and embodied intelligence, scaling to entire cities remains an open challenge, primarily due to the lack of city-scale data. To bridge the gap, we introduce WildCity, a real-world multimodal dataset collected by autonomous fleets traversing complex urban environments. Our dataset includes 18 trajectories, each averaging 83.7 kilometers in length, and preserves the core challenges of in-the-wild perception, e.g., dynamic objects, lighting variations, and imperfect camera poses. We further establish an urban-tailored reconstruction baseline and convert the reconstructed environments into a closed-loop simulator. Beyond the dataset and baseline, we systematically analyze the key challenges on the path to simulation-ready urban digital twins: scalability, extrapolation, and uncertainty. Ultimately, WildCity aims to catalyze progress not only in city-scale rendering, but more broadly in the pursuit of AI that can perceive, remember, and reason across space at a scale comparable to human cognition. Project page: https://han-xiangyu.github.io/Wild-City/

Autonomous driving systems require reliable safety validation before real-world deployment. However, large-scale road testing is costly, difffcult to reproduce, and inefffcient for exposing rare safety-critical scenarios. Conventional simulation improves repeatability, but an offfine simulator alone cannot continuously connect physical trafffc states, virtual reconstruction, algorithm evaluation, and scenario evolution. This paper proposes a risk-ffeld enhanced closed-loop digital twin framework for autonomous driving safety validation. The framework integrates physical data acquisition, data synchronization, virtual twin reconstruction, risk-aware scenario generation, autonomous driving algorithm evaluation, and safety analysis. A driving risk ffeld is introduced as a uniffed intermediate representation to describe obstacle, lane-departure, road-boundary, time-to-collision, and comfort-related risks around the ego vehicle. The risk ffeld ranks high-risk scenarios in the digital twin scenario library and provides dense safety guidance for reinforcement learning-based driving policies. A simulation-style evaluation protocol is designed to compare conventional reinforcement learning baselines, risk-penalty baselines, and the proposed risk-ffeld guided method. The study indicates that embedding explicit risk structure into digital twins can make autonomous driving validation more targeted, interpretable, and reusable, while its practical effectiveness remains bounded by model ffdelity, risk calibration, and sim-to-real transfer.

Dilution refrigerators are the enabling infrastructure of superconducting quantum computers, yet their fault diagnosis is still dominated by threshold alarms that report that something is wrong, not what. We present Onnes, a physics-grounded digital-twin simulator of a dilution refrigerator (a forward physics model with a learned real-fridge noise fingerprint) that drives a live multi-agent LLM operations layer, and use it for a controlled head-to-head between a zero-shot LLM agent panel and a supervised ML classifier on cryogenic fault diagnosis. The twin couples a real dilution-cooling floor, a noise-and-correlation fingerprint learned from real BlueFors logs, and six physics-grounded fault classes, three engineered to overlap on temperature but separate on flow and pressure. Across a 1000-turn evaluation the zero-shot panel shows no significant difference from the classifier on detection but trails on classification, its errors concentrating on the confusable faults. Curated contrastive few-shot demonstrations and self-consistency voting then raise classification accuracy from 0.685 to 0.990, matching the supervised classifier (0.985) with no parameter updates and six labeled demonstrations; an ablation attributes the gain almost entirely to the demonstrations. Run as a continuous monitor across a nine-run fault-by-seed sweep, the agent catches every developing fault within one poll interval, and a confidence gate suppresses pre-onset false alarms whose rate is backend-dependent. As a first sim-to-real check, a detector trained purely on real BlueFors telemetry posts a real-hardware false-alarm rate of 6.4% and 100% recall on physics faults injected onto real held-out windows. All numbers are drawn verbatim from released run logs.

Automated experimentation is moving from closed-loop optimization toward open decision-making, where human or AI planners must forecast the consequences of candidate actions before executing them. Such forecasts require a model of both sides of the experiment: how the sample is likely to respond and what the instrument is likely to detect. We therefore introduce a coupled digital-twin framework that separates these roles and then links them. In this framework, the sample twin encodes material state inferred from prior knowledge and measurements till the moment. The instrument twin captures signal formation, feedback dynamics, and operating constraints based on prior knowledge. When coupled, the two twins estimate expected outcomes, uncertainty, and risk for candidate microscope operations. For amplitude-modulation scanning probe microscopy, we realize this framework with a physics-informed encoder of force-distance curves, a deterministic scanner model of cantilever and feedback dynamics, and sparse learned residual corrections. The encoder first recovers scanner-driving descriptors with sub-nanometer accuracy. The calibrated scanner then reproduces typical traces within a few nanometers and identifies operating-point noise amplification as the main source of mismatch. Supplementary phase analysis localizes residual error to the phase channel, which clarifies where added physics is needed. Together, these results establish coupled sample and instrument twins as a practical foundation for predictive microscope operation and autonomous experimental planning.

The aging global population drives demand for assistive robots, yet the safety risks and costs of physical testing make Human-in-the-Loop (HITL) simulation an attractive alternative. Its fidelity for coupled systems, however, is limited by interaction models whose impedance parameters are tuned heuristically rather than identified from data. We present a Real2Sim pipeline that identifies the coupled Physical Human-Robot Interaction (pHRI) dynamics of a pelvis--strap interface on an overground mobile balance assistant. The interface is modeled as a 6-DoF viscoelastic mechanism whose 12 directional stiffness and damping parameters are identified per subject via Covariance Matrix Adaptation Evolution Strategy (CMA-ES), using the user's ``Safe & Comfortable'' feedback as a reproducible operating point that resolves harness-tightness ambiguity across anthropometrics. An intraclass-correlation analysis over a five-subject cohort separates shareable from subject-specific parameters, yielding a set of prior parameters derived from the existing data. Deploying this prior configures a previously unseen subject by refining only 5 of the 12 parameters. The calibrated model then reproduces the real interaction envelope and induces biomechanically accurate gait adaptations in the Human Digital Twin (HDT). Overly compliant and overly stiff settings, by contrast, fail as extreme settings, confirming a correct operating point that no heuristic tuning procedure can reliably select. The pipeline thus improves HITL simulation fidelity and supports the Human Digital Twin as a predictive tool for pre-clinical verification of personalized controllers.

Patient-specific anatomical models provide individualized context for surgical planning, image-guided intervention, and algorithm development. However, most CT-derived models are static: they preserve the body configuration captured at scan time, but cannot represent how the same anatomy would appear after patient repositioning. This limitation is especially important for radiographic imaging, where appearance depends jointly on imaging geometry and patient pose. We present a proof-of-concept for constructing a patient-specific articulated digital twin from a single full-body CT scan. The method fits a parametric human body model (SMPL) to obtain a patient-aligned kinematic scaffold, binds segmented bones and organs to an anatomy-aware rig, and retargets body-pose changes while preserving skeletal geometry. On three full-body CT subjects, the fitted scaffold achieved 15.8 $\pm$ 4.0 mm chamfer distance and 95.9 $\pm$ 1.8% skeletal enclosure. Recomposition at the acquisition pose preserved major radiographic structure, with overall SSIM of 0.872 $\pm$ 0.016 and PSNR of 18.5 $\pm$ 1.4 dB across paired DRRs. Across unseen target poses, the resulting twins enabled articulation while maintaining high skeletal enclosure (94.4 $\pm$ 0.4%). As a feasibility demonstration, we render the articulated twin as pose-dependent DRRs. These results suggest the feasibility of extending static, view-controllable CT simulation toward pose-controllable anatomical twins for future synthetic imaging and positioning studies.

Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost. We show that this blind spot misranks models: across 11 architectures, models with comparable pointwise error diverge by up to 53° in phase accuracy, equivalent to roughly 123 ms for a 1.2 Hz cardiac rhythm and invisible to standard metrics. To enable development of models that escape such failures, we introduce TimeSynth, a controlled benchmarking framework with two reusable components: a physiologically grounded generator producing signals with analytically known ground-truth dynamics from parametric models fitted to real electroencephalography, electrocardiography and photoplethysmogram signals, along with diagnostics quantifying amplitude, frequency, phase, and state-transition fidelity. Linear and full-sequence attention models systematically lose frequency and phase information despite acceptable amplitude error, whereas architectures with localized temporal structure better preserve dynamical fidelity and adapt to observable state transitions; none, however, reliably preserves stochastic switching. Because the dominant determinant of fidelity is architectural, model choice becomes a principled, use-case-driven decision rather than a search for a single winner. TimeSynth thus supplies the controlled preclinical stress test missing before models are coupled to patient data, with a reusable generator and diagnostics for fidelity-aware development.

In the verification of in-vehicle cameras, simulation technology using virtual spaces has advanced, enabling pre-evaluation of false detections and missed detections in various scenarios. However, discrepancies in the scale of the object being verified between the virtual and real environments can lead to a decrease in camera recognition performance. For traffic signs installed at high altitudes, distance measurement using LiDAR or stereo cameras is difficult, requiring size estimation from monocular images. This paper proposes a method for estimating the scale of an object by decomposing it into multiple structural elements and integrating external knowledge regarding design rules, geometric relationships, and conventional dimensions. Specifically, this method detects each component from a monocular image and estimates the size of each component by considering its structural relationships and dimensional consistency with surrounding elements. Furthermore, it generates a 3D asset of the object by reconstructing the estimated components. This method makes it possible to place 3D assets with a scale approximating the real environment within a digital twin space and is expected to contribute to improving the verification accuracy of in-vehicle cameras for autonomous driving in virtual environments.

Connected Vehicles (CVs) rely extensively on communication technologies to enable data-driven predictive analyses for enhancing performance and safety. These communication channels can be exploited by adversaries to launch cyberattacks such as Sybil attacks, which could threaten both safety-critical and mobility applications, leaving CVs vulnerable and putting human lives at risk. As CV deployment continues to expand, the need to detect and mitigate cyberattacks in real-time becomes increasingly urgent. This study presents an in-vehicle Digital Twin (DT)-based collision warning framework with built-in capabilities for Sybil attacks detection. The framework integrates a Temporal Convolutional Network (TCN) for learning temporal dependencies in vehicle trajectory data and Hierarchical Navigable Small World (HNSW) algorithms for efficient similarity-based classification. Our framework is evaluated on real-world Sybil attack data, collected through field experiments. The framework achieved accuracy, recall, and F1 scores of 0.984, 1.00, and 0.944, respectively, in detecting Sybil-generated fake vehicles. During the safety evaluation, the framework reduced the mean Time Exposed Time-To-Collision (TET) and mean Time Integrated Time-To-Collision (TIT) of near-collision events by 88% and 72%, respectively. Furthermore, real-world feasibility evaluation shows that the framework conformed to the standardized maximum allowable latency for safety applications and operated well within the capacity of modern processors -- demonstrating the promise of an in-vehicle DT-based framework as an attack mitigation mechanism against Sybil attacks for next-generation CVs.

Training and evaluating robot policies in the real world is costly and difficult to scale. We introduce SimFoundry, a modular and automated system for zero-shot real-to-sim scene construction from a video. SimFoundry generates sim-ready digital twins and supports object, scene, and task editing, enabling the automated generation of diverse digital cousins: affordance-preserving variations of reconstructed real-world scenes. Policies trained on SimFoundry data transfer zero-shot to challenging real tasks involving multi-step manipulation, articulated object interaction, and bimanual interaction, and its digital cousins (variations of the original scene, objects, and tasks) facilitate generalization to new real-world conditions. Across 7 manipulation tasks and 5 policy architectures, SimFoundry simulation evaluations strongly predict real-world performance, with mean Pearson correlation 0.911 and mean maximum ranking violation 0.018. When evaluating sim-trained policies zero-shot in the real world, policies trained with object, scene, and task cousins in simulation show average task success rate improvements of 17%, 21%, and 40%, respectively. Additional details at https://research.nvidia.com/labs/gear/simfoundry/ .