Digital Twins

The study of opinion dynamics in social networks is one of the key challenges in computational social science with direct relevance to understanding political polarization, misinformation, and health responses. Current approaches focus on simplified mathematical models that ignore linguistic and contextual factors related to belief updates or use Large Language Model (LLM)-based simulations that have not been validated against real data. We present a framework based on the concept of a digital twin to simulate opinion dynamics in social networks. The approach fills the gap by cloning a real-world Twitter network, assigns a set of attributes for agents (such as persona, emotions, centrality, stubbornness, and influence), and employs Mistral-7B to perform opinion update based on memory and social exposure. To evaluate the proposed approach, we validate it against two real Twitter datasets (COVID-19 discourse and U.S elections 2020). The results show that the capability of the proposed framework reproduces opinion trajectories and reduces individual prediction error by more than 50% compared to the best-performing classical baseline (Mistral-7B achieves Mean Absolute Error (MAE) = 0.150 and 0.121 on the COVID-19 and US Election 2020 datasets, respectively). We observe similar improvements in structural alignment (Delta_r = 0.120 and 0.180) and polarization dynamics (Delta_Var = 0.106 and 0.115) on the two datasets, respectively. Additionally, the ablation studies confirm that agent attributes, memory, and social exposure all contribute to the framework's predictive fidelity in reproducing opinion trajectories, with agent attributes being the most critical contributor. Overall, our results demonstrate that grounding Mistral-7B within empirically cloned interaction networks produces a realistic simulation framework capable of reproducing complex social dynamics.

Modern networks must support changing topologies, configurations, and performance objectives, motivating fast and reliable performance estimation. Network digital twins (NDTs) enable what-if analysis for performance estimation in such network scenarios, however, existing machine learning-based NDT approaches often rely on entire topology representations, which are inherently monolithic and lack reusability under topological or traffic changes in the network. This paper introduces a composable NDT approach that decomposes networks into subgraphs represented by reusable unit twins that capture subgraph structure, configuration and traffic behaviours. A lightweight composer aggregates unit twin combinations to create NDTs that predict per-route end-to-end latency through an overall topology. Evaluation across controlled synthetic topologies and diverse traffic scenarios, real-world Topology Zoo topologies, and a public NDT challenge dataset demonstrates that the composable NDTs achieve high in-distribution accuracy while remaining stable under out-of-distribution scenarios. Comparison with monolithic full topology NDTs demonstrates that our composable approach achieves reusability, while achieving comparable or superior accuracy.

City pedestrian counting systems now feed economic indicators, planning decisions and safety operations, yet the twins built on top of them treat the incoming stream as ground truth. We study what happens when it is not. We formalise stealthy false data injection for city-scale pedestrian sensing, where the map from latent flow to observation is far more rank deficient than in the power and water networks for which stealth has been characterised. Our twin estimates directed flows on the pedestrian street graph, assimilates counts through a learned graph-localised gain, and is trained against a flow conservation residual that couples metered and unmetered segments. Detection combines the innovation with that residual, and the alarm threshold is set by adaptive conformal calibration rather than by hand. To measure what the physics buys, we define the attack margin, the relative reduction in worst-case corruption of the estimated flow field, achieved against a white-box adversary that optimises directly through the twin. On six years of Melbourne data the margin reaches 0.54 against a single compromised device and falls to 0.19 when a third of the fleet is compromised, on a network where only 1.18 per cent of walkable segments are metered. Replacing the street graph by a distance graph collapses it to 0.09, which shows that the gain comes from the conservation law rather than from locality.

As Digital Twin (DT) systems evolve beyond state synchronization toward task-oriented and knowledge-driven operation, Cognitive Digital Twins (CDTs) have emerged as an extension that incorporates cognitive capabilities into twin operation. Existing CDT studies often focus on specific enabling techniques, such as learning modules, knowledge graphs, and large language models, while providing limited insight into how cognition can be systematically integrated into DT architectures. To address this issue, this paper proposes a four-layer CDT architecture consisting of the physical layer, digital-twin layer, cognitive layer, and task layer. The proposed architecture establishes a self-evolving closed operational loop spanning these four layers, in which physical states are synchronized into digital representations, cognition constructs task-specific cognitive models through knowledge, memory, and attention, and task-level decisions are generated under practical constraints. Operational feedback further refines cognitive experience and updates relationships and annotations in the digital representation, enabling subsequent task interpretation, initiation, and reasoning to evolve with system operation. Based on this framework, two representative operation modes are characterized: user-request-driven cognition and self-driven cognition. We further discuss key enabling mechanisms and deployment challenges associated with semantic communication, knowledge querying, task orchestration, and closed-loop synchronization. A lightweight simulation study illustrates reliable closed-loop task feasibility under limited semantic information and improved operational efficiency through accumulated task experience. The proposed framework provides a structured foundation for the design and development of future CDT systems.

LLM-based digital twins promise to reduce repeated human data collection by generating person- specific responses, yet existing evaluations provide little evidence about whether they can reduce human measurement while preserving valid inference. To address this, we introduce statistical substitutability, an inferential criterion that evaluates the extent to which twin predictions can reduce human measurement for a particular estimand while preserving valid inference. We develop a framework, grounded in mixed-subject and prediction-powered inference, that evaluates statistical substitutability along four dimensions: aggregate fidelity, paired respondent-level signal, finite-sample human-label recovery, and stability across populations. Across two empirical evaluations spanning behavioral experiments, multiple models, and alternative respondent representations, we find that digital twins can reproduce average human effects while providing little information about which individuals differ from those averages. Newer models and richer respondent information improve some dimensions of performance but do not reliably translate into human-data savings. Human calibration can reduce aggregate prediction error, yet limited labeled samples often fail to produce stable precision gains. Importantly, these findings demonstrate that behavioral fidelity is neither necessary nor sufficient for statistical substitutability. More broadly, they suggest that AI-generated evidence should be evaluated based on its ability to support valid scientific inference rather than its ability to reproduce human outcomes alone. Digital twins should therefore be judged for confirmatory use by whether they reduce uncertainty about human quantities, not merely by whether they reproduce human means, distributions, or effects.

3D reconstruction typically strives for geometric fidelity or visual plausibility. Radio frequency digital twins (RFDT) are instead judged by whether communication channels behave in them as they do in the real world. RFDTs promise site-specific channel prediction but current practice forces a choice between coarse automated scenes and hand-built, measurement-calibrated models that take weeks to construct per-site. We present KODAMA, an automated pipeline that reconstructs ray tracing-ready RFDTs at city scale from off-the-shelf geospatial data alone: aerial imagery, LiDAR, and photogrammetry yield terrain and watertight building meshes, while exposure-weighted multi-view fusion of street-level imagery recovers façade relief, electromagnetic materials, and clutter---all without site visits or calibration. Across three sites spanning 3.6 to 28 GHz, KODAMA's uncalibrated predictions achieve single-digit RMSE, reducing point-to-point error by up to 5.35 dB over automated baselines and coming within 0.22 dB of a measurement-calibrated, hand-built RFDT.

AI agents increasingly gather evidence, invoke tools, apply constraints, and produce decisions that people or software may commit to action. A final output alone cannot show which evidence, tool state, rule, authorization, or action path produced it. We present DNative-Twin, a graph-native digital twin that records a committed agentic decision as a typed trajectory and re-executes its decision mechanism under declared conditions. The graph links the state observed by the agent, the path it followed, and the authority behind the resulting action. The twin synchronizes this information, replays the mechanism in isolation, and compares it under controlled changes. We instantiate the framework in enterprise decision processes using three public process logs and controlled replay suites. The experiments identify a specific failure: graph structure localizes represented changes but cannot determine the consequence of an unobserved tool state. In a three-condition controlled experiment with 300 injected instances, unresolved-divergence recall increased from 0 to 0.667 when replay-contract state was added and to 1.0 when verification results were also available; the held-out set contained no critical-class instance. Across 500--5,000 BPI 2020 cases, median end-to-end time increased from 0.794 to 8.889 seconds on the reported platform. These results separate the roles of graph structure, replay context, and verification evidence in reviewing a decision mechanism.

Digital twins are increasingly used to monitor and simulate the behavior of cyber-physical systems. Even with skilled operators, interpreting anomalies detected within digital twin pipelines is challenging, as the sheer complexity and volume of raw sensor data make thorough analysis difficult. Recent advances in large language models (LLMs) offer promising capabilities for reasoning and explanation, yet their integration into digital twin-driven anomaly analysis remains underexplored. In this work, we propose AgenticTwin, an agentic framework that integrates LLM-driven reasoning with a digital twin-based anomaly detection pipeline. The framework grounds LLM-generated explanations in outputs from a digital twin-driven anomaly classifier and enables human operators to ask relevant natural-language questions about the system. Beyond the framework itself, we introduce a benchmark-oriented evaluation pipeline constructed over synthetic anomalies injected into a real-world weather sensor dataset, enabling controlled generation of operator queries over anomaly events. We further evaluate the feasibility of deploying lightweight, open-source LLMs for practical cyber-physical environments. Experimental results demonstrate that structured agent collaboration and knowledge-grounded reasoning improve diagnosis quality, contextual retrieval, and mitigation quality across diverse possible anomaly scenarios.

Accurate physical-layer modeling is increasingly essential for reliable ultra-wideband operation and capacity optimization, especially under the intensified inter-channel stimulated Raman scattering (ISRS) effect. This paper proposes the link-adaptive digital twin (LA-DT) for hybrid-amplified ultra-wideband links to overcome the generalization and speed limitations of existing methods, achieving accurate modeling and robust generalized signal-to-noise ratio (GSNR) estimation across diverse links. First, to address EDFA heterogeneity, the GSNR modeling task is decomposed into three key power predictions: ASE, NLI, and signal powers before EDFA entry. Second, to enhance cross-scenario generalization, three dedicated DT models are developed using a novel neural architecture with linear modulation layers (LMLs). Third, for rapid adaptation to unseen scenarios with limited data, three domain discriminators guide few-shot fine-tuning of the LMLs. Fourth, the LA-DT explicitly accounts for Raman amplifier (RA) insertion loss, improving practical deployment reliability. Results across 35 scenarios show that LA-DT reduces RMSE for NLI, ASE, and signal power predictions to 0.151, 0.111, and 0.113 dBm with improvements of 56.0%, 58.4%, and 52.7% over the baseline,and achieves an average GSNR estimation RMSE of 0.114 dBm (55.8% improvement). For 12 unseen scenarios, the LA-DT maintains high accuracy through few-shot fine-tuning with only 20 samples per scenario, achieving an average GSNR RMSE of 0.159 dB and demonstrating strong adaptability and robustness.

Social media affect financial markets, but public posts by financial media personas are voluntary disclosures. What is not disclosed is therefore usually unobserved. We address this measurement problem by conducting repeated, real-time interviews of "digital twins" built from monitored finfluencers' X accounts under a fixed protocol. The interviews recover stock-level public-persona belief proxies even when no public recommendation is made. Because the interviews are generated and archived before the relevant return windows, the design avoids the look-ahead bias that arises when LLMs are queried ex post. The evidence shows that information obtained from these digital-twin interviews predicts the cross section of large-cap stock returns in the expected direction. Repeated real-time interviews therefore show how selective disclosure can be turned into measurable panels of market views.

Accurate indoor localization is essential for emerging applications in robotic navigation and search and rescue. While classical methods typically focus on single-point estimates, complex indoor environments with heavy blockage and multipath propagation often lead to multimodal likelihood surfaces where a single estimate is insufficient. This paper proposes LOCUS-DT (Localization via Observation-Conditioned Uncertainty Scoring with Digital Twins), a framework that treats snapshot localization as posterior inference over the transmitter location. By leveraging a ray-tracing-based digital twin (DT) of the known environment, LOCUS-DT generates synthetic multipath profiles for candidate locations and compares them against the measured channel profile. Central to our approach is a novel learned scoring function designed to compare a fixed number of dominant specular paths, providing robustness against errors in both the DT environment model and the physical channel estimation. Importantly, LOCUS-DT is trained over an ensemble of environments to ensure generalization to unseen layouts. We evaluate the system using a Sionna-based ray-tracing backend, demonstrating that LOCUS-DT captures the sharp, multimodal posterior structures inherent in indoor settings more accurately than standard Gaussian or Gaussian-mixture benchmarks.

Digital twins have emerged as a foundational technology within the context of Industry 4.0, offering a paradigm for the real-time virtual representation of physical systems. However, managing their growing complexity, particularly in distributed industrial environments, requires intelligent architectures capable of autonomous decision-making, dynamic adaptability, and inter-agent coordination. This systematic review explores the intersection between Multi-Agent Systems and Digital Twins, with a particular focus on predictive maintenance applications in resource-constrained contexts. Through a critical analysis of over 547 papers published in high-impact journals (IEEE Transactions, Nature, Elsevier, MDPI), we establish a taxonomy of existing hybrid architectures, identify persistent technological bottlenecks, and formulate three open research questions concerning: (i) the deployment of artificial intelligence on resource-constrained microcontrollers, (ii) distributed multi-node coordination via lightweight communication protocols, and (iii) the hierarchical orchestration of Digital Twins toward smart factory control integrating residual life estimation and explainable Artificial Intelligence. The results of this analysis reveal that, despite significant progress, no existing system offers an integrated embedded-distributed hierarchical solution that simultaneously meets the requirements of Industry 5.0.

Digital twins are often used to predict how a system would respond to an intervention. In systems with feedback, a twin must reproduce an equilibrium counterfactual, and a twin developed in one domain may fail after mechanisms change. We study when these predictions can be validated and transported. For equilibrium causal games, we give conditions on the mechanisms, equilibrium selection, and intervention design under which agreement with experimental distributions identifies the counterfactual of interest. We show why agreement of means and covariances is insufficient for distributional queries. We then introduce cyclic selection diagrams and derive criteria for direct reuse and for hybrid models that combine invariant source mechanisms with target information. An impossibility result constructs systems that agree under every experiment in a finite design but disagree on the target counterfactual, showing that validation requires structural assumptions. For linear models, we derive intervention requirements that depend on the mechanisms that changed, the observation model, and graph support. When point identification fails, we characterize the remaining range of query values. We also provide statistical tests for reconstructed means and covariances and illustrate the theory in synthetic feedback systems.

In efforts to increase research efficiency and availability, a digital twin of our research tractor (AMX G-trac) is created, focusing especially on the CAN communication for data reading and actuation command following the ISOBUS protocol. Mevea Simulation Software is utilized as the foundation, providing the kinematic model and visuals, while Python is used to read and write CAN messages over a Kvaser CanKing virtual CAN channel. Various performance tests involving straight line and turning behavior are performed in both the digital twin simulation and in the real world to measure similarity. Results indicate that the Mevea model behaves very comparable in its lateral dynamics, often within 5-10 percent, but requires better data to fully capture the longitudinal aspects like acceleration. The final model described in this paper sets the table for a second iteration to include more tractor functions such as hydraulics and tractor-implement dynamics.

This work addresses the need for engineering-grounded evaluation of implement-ed tariff mechanisms in distribution-level energy systems. A digital twin-based method is proposed for assessing local collective tariffs under realistic behavioral and infrastructural conditions. The approach integrates agent-based modeling of household consumption and generation, virtual aggregation through a shared metering abstraction, and explicit representation of tariff logic within a unified simulation environment. The method is demonstrated through its application to the Danish Local Collective Tariff across representative residential energy community configurations, including scenarios with photovoltaic generation, battery storage, and electric vehicle charging. Results indicate that aggregation of heterogeneous demand profiles reduces peak coincidence and enables more efficient allocation of tariff components, leading to measurable cost reductions at the community level. At the same time, the outcomes reveal sensitivity to the temporal alignment of consumption and generation, influencing the degree of cost neutrality across participants. The findings illustrate how digital twin-based evaluation can support systematic assessment of tariff mechanisms by capturing the interaction between infrastructure, user behavior, and regulatory design. The proposed approach provides a basis for analyzing and comparing tariff structures in distribution-level energy systems beyond the specific case considered.

Digital twins enable robots to anticipate and adapt to physical interactions, but existing models struggle with elastoplastic articulated objects (EAOs) that exhibit nonlinear elasticity, plastic yielding, and damage accumulation. We present BoxTwin, an interactive digital twin framework that learns the full dynamics of EAOs from videos. Our pipeline reconstructs the scene, identifies a physics aware constitutive model for each EAO. Experiments on manual folding and dual arm manipulation of EAOs show that BoxTwin accurately tracks joint trajectories and reproduces post contact plastic behavior over long horizons. By integrating video driven reconstruction with elastoplastic damage modeling, BoxTwin advances digital twins toward predictive, adaptive control of deformable articulated objects in unstructured environments.

Brain tumor progression exhibits spatially heterogeneous growth, patient-specific treatment response, and complex interactions with surrounding anatomy, making accurate long-term prediction challenging. We propose an AI-augmented adaptive digital twin (DT) framework for brain tumor evolution prediction and treatment scheduling. The framework integrates an interpretable reaction--diffusion (RD) model, a 3D residual learning module for model-form correction, patient-specific DT updating during recursive rollout, and model predictive control (MPC) for constrained chemotherapy and radiotherapy scheduling. Experiments on 387 synthetic tumor trajectories with 120-step evolution show that the baseline RD model captures tumor location and overall temporal behavior but underestimates heterogeneous tumor burden during long-horizon prediction. Hybrid RD--residual modeling reduces masked voxel-wise mean squared error by 84.3% and increases Dice overlap by 43.5% relative to the RD baseline under dense simulated observations. Online DT updating further reduces mean squared error by 45.9% and improves Dice overlap by 9.6% compared with the non-updated hybrid model. In MPC-based scheduling simulations, the updated DT controller reduces final tumor burden by 22.4% relative to a fixed treatment schedule under the terminal-burden objective. Together, these results demonstrate a unified framework for patient-specific initialization, mechanistic modeling, adaptive learning, and constrained treatment optimization. Although validated using patient-data-informed synthetic trajectories rather than clinical longitudinal data, the proposed framework establishes a foundation for future translation to real-world adaptive treatment planning.

This book chapter covers the evolution of social simulation from classical agent-based models, in which agents interact according to explicitly defined behavioral rules, to AI-enhanced simulations based on Large Language Models and, ultimately, Social Digital Twins: high-fidelity, data-driven representations of real-world socio-technical systems. Along this trajectory, we discuss the main methodological foundations, applications, advantages, and limitations of each paradigm, highlighting the progressive shift from abstract models designed to investigate general social mechanisms toward increasingly realistic computational representations of specific social systems.

Existing approaches to infer user traits and generate responses consistent with a persona rely on static prompting. They lack calibrated uncertainty, ignore sequential evidence, and drift during long interactions. We present \textbf{AI YOU}, a framework that continually updates a personality profile with 22 dimensions from conversation and embodies it in a personal digital twin. Practically, the system combines prompting, Bayesian updating, and conformal prediction for persona inference. A periodically refreshed memory anchor and cognitive memory with three layers preserve persona consistency over long interactions. Across the main results, AI YOU \emph{(i)} achieves conformal coverage ranging from 0.921 to 0.976, \emph{(ii)} improves uncertainty calibration and reasoning grounded in memory, and \emph{(iii)} enhances persona fidelity over static prompting in role playing over 100 turns while reducing trait drift, for most evaluated backbones under adversarial settings with multiple agents. The prototype \emph{AI YOU Town} initializes an imaginative twin world for future interaction. The online demo is available at \href{https://quinnnnnne-ai-you.hf.space/}{\mbox{\texttt{quinnnnnne-ai-you.hf.space}}}.

Federated reinforcement learning (FRL) is crucial for enabling collaborative learning across multiple agents without sharing raw data, thereby enhancing privacy and scalability in the decision-making process within dynamic vehicular environments. However, poisoning attacks pose a significant threat to the security and reliability of FRL-based systems, particularly in safety-critical autonomous driving, where this vulnerability remains largely unexplored. These attacks can compromise the global control model by subtly injecting malicious system parameters, leading to potential hazards. To counter these challenges, we present \alg (\underline{Sec}ure \underline{A}ggregation with \underline{p}oisoning-\underline{p}revention and historical reinforcement) as a defensive framework aimed at enhancing the robustness of FRL systems designed for safety-critical driving scenarios. \alg strategically integrates digital twins for rehearsal-based learning and leverages historical aggregated model parameters along with a selected central gradient to ensure that only benign data is aggregated, effectively mitigating the influence of malicious agents. Theoretical guarantees are provided for the convergence performance of \alg in the presence of poisoning attacks. We also validate the effectiveness of \alg using developed digital twins that model realistic highway environments to evaluate the control of autonomous vehicles under adversarial conditions.

Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested. Existing reinforcement learning (RL) approaches learn fixed strategies for sepsis treatment, limiting adaptability to changing clinical objectives during inference. We propose EHRMPC, a framework that decouples learning patient dynamics from optimizing treatment by training a patient digital twin in the form of a generative electronic health record (EHR) model. The digital twin predicts clinical trajectories under interventions and enables model predictive control (MPC) to optimize treatments via inference-time planning over simulations. We evaluate EHR-MPC on a multicenter ICU sepsis cohort spanning 8 hospitals in the Mass General Brigham health system using both off-policy importance sampling and on-policy simulation-based evaluation. Relative to RL baselines, EHR-MPC achieves comparable off-policy performance and improved simulation performance. Unlike RL, this work frames sepsis treatment optimization as inference-time control over learned patient dynamics, establishing a general framework for decision making with generative clinical models.

Automated experimentation is moving from closed-loop optimization toward open decision-making, where human or AI planners must forecast the consequences of candidate actions before executing them. Such forecasts require a model of both sides of the experiment: how the sample is likely to respond and what the instrument is likely to detect. We therefore introduce a coupled digital-twin framework that separates these roles and then links them. In this framework, the sample twin encodes material state inferred from prior knowledge and measurements till the moment. The instrument twin captures signal formation, feedback dynamics, and operating constraints based on prior knowledge. When coupled, the two twins estimate expected outcomes, uncertainty, and risk for candidate microscope operations. For amplitude-modulation scanning probe microscopy, we realize this framework with a physics-informed encoder of force-distance curves, a deterministic scanner model of cantilever and feedback dynamics, and sparse learned residual corrections. The encoder first recovers scanner-driving descriptors with sub-nanometer accuracy. The calibrated scanner then reproduces typical traces within a few nanometers and identifies operating-point noise amplification as the main source of mismatch. Supplementary phase analysis localizes residual error to the phase channel, which clarifies where added physics is needed. Together, these results establish coupled sample and instrument twins as a practical foundation for predictive microscope operation and autonomous experimental planning.

Patient-specific anatomical models provide individualized context for surgical planning, image-guided intervention, and algorithm development. However, most CT-derived models are static: they preserve the body configuration captured at scan time, but cannot represent how the same anatomy would appear after patient repositioning. This limitation is especially important for radiographic imaging, where appearance depends jointly on imaging geometry and patient pose. We present a proof-of-concept for constructing a patient-specific articulated digital twin from a single full-body CT scan. The method fits a parametric human body model (SMPL) to obtain a patient-aligned kinematic scaffold, binds segmented bones and organs to an anatomy-aware rig, and retargets body-pose changes while preserving skeletal geometry. On three full-body CT subjects, the fitted scaffold achieved 15.8 $\pm$ 4.0 mm chamfer distance and 95.9 $\pm$ 1.8% skeletal enclosure. Recomposition at the acquisition pose preserved major radiographic structure, with overall SSIM of 0.872 $\pm$ 0.016 and PSNR of 18.5 $\pm$ 1.4 dB across paired DRRs. Across unseen target poses, the resulting twins enabled articulation while maintaining high skeletal enclosure (94.4 $\pm$ 0.4%). As a feasibility demonstration, we render the articulated twin as pose-dependent DRRs. These results suggest the feasibility of extending static, view-controllable CT simulation toward pose-controllable anatomical twins for future synthetic imaging and positioning studies.

Digital twins have emerged as a promising paradigm for personalized healthcare, enabling modeling of individual behavior and health trajectories. In cognitive health, early detection of Mild Cognitive Impairment (MCI) remains challenging, where language and conversational patterns serve as non-invasive biomarkers. In this work, we propose a language-based digital twin framework that leverages large language models (LLMs) to mimic the conversational behavior of elderly individuals by incorporating stylometric cues and contextual metadata. To evaluate fidelity and cognitive consistency, we introduce a multi-head conditional variational autoencoder (cVAE) that jointly measures reconstruction quality and predicts cognitive scores. Experiments on the I-CONECT dataset show that the digital twin preserves identity-specific characteristics and achieves reconstruction and MoCA prediction errors comparable to real data, while outperforming baseline GPT-generated responses. These results highlight the potential of language-based digital twins as a scalable and non-invasive approach for personalized and continuous cognitive health monitoring.

A digital twin (DT) is a virtual model of a real-world system that can assist decision-making by simulating scenarios induced by different policies. However, typical machine learning-based DTs do not optimise for this use case. We prove that, when model capacity is limited, training DTs to minimise one-step transition errors can produce suboptimal models for ranking sets of policies according to a reward function. We further show that this holds empirically, even with expressive model classes. To address this, we introduce $\text{DT}^2$, a decision-targeted DT training paradigm. Firstly, $\text{DT}^2$ uses fitted Q-evaluation to estimate values of candidate policies from offline data. A DT is then trained to generate rollouts that preserve pairwise policy rankings derived from these proxy ground-truth values with an architecture-agnostic loss function. We empirically demonstrate the efficacy of our method across a range of settings and architectures. $\text{DT}^2$ consistently improves policy ranking and reduces decision regret during policy selection relative to conventional DT training, both for policies used during training and for unseen policies, while maintaining a good level of raw simulation fidelity.

Bathroom use is a critical safety challenge for older adults because wet surfaces, constrained layouts, limited support, and frequent posture transitions are concentrated within a small domestic space. These conditions create risks that cannot be adequately understood by considering either the bathroom environment or human motion in isolation. Existing bathroom safety studies mainly identify hazards, accessibility problems, or design modifications, whereas human-centered sensing studies often focus on activity recognition or fall detection without sufficient semantic understanding of the surrounding environment. This separation limits the interpretation of how older adults interact with fixtures, support surfaces, wet areas, and spatial constraints during daily bathroom activities. To address this gap, this study proposes a bathroom-centered human-building digital twin framework for interaction-aware indoor safety analysis with a specific emphasis on older adult bathroom safety. The framework conceptualizes bathroom risk as a coupled human-environment process and integrates semantic bathroom representation, skeleton-based human representation, spatial-semantic coupling, interaction-aware event analytics, and safety-oriented visualization. A Unity-based proof-of-concept prototype is developed to demonstrate the feasibility of the framework. Although the current work remains a prototype-oriented investigation, it establishes a methodological basis for analyzing older adults' bathroom safety through explicit body-environment relations and for advancing privacy-sensitive, interaction-aware digital twin applications in aging-in-place residential environments.

Digital twins (DTs) have become a potential technology to perform risk-free simulation of physical entities for deterministic and high-reliability services in diverse scenarios such as autonomous driving and low-altitude economy. In the autonomous driving scenario, traditional DT methods that rely solely on vehicle's real-time state synchronization, however, might lead to unacceptable computing and communication consumption for construction of high-fidelity DT with redundant data. To address this issue, we first propose a query-driven DT architecture to enable the DT to actively request the desired environment data from vehicles based on its simulation result. Then, we formulate an optimization problem whose goal is to minimize autonomous driving position error while accounting for DT fidelity and communication constraints. We also design a cross-time-step progressive query mechanism to further improve communication efficiency. The simulation results show that our proposed method achieves a 24% reduction in planning position error compared to traditional methods, while reducing communication overhead by 40%.

Precision medicine in ophthalmology requires accurate longitudinal predictions, but the fragmented nature of multimodal clinical data remains a barrier to forecasting. We introduce OphthaDT, an LLM-based digital twin for ophthalmology that serializes longitudinal patient histories from 3,220 patients across four Phase III clinical trials into structured narratives to forecast best corrected visual acuity (BCVA). In benchmarks spanning up to 100 weeks, OphthaDT demonstrated the lowest prediction error in neovascular age-related macular degeneration (nAMD), achieving an average mean absolute error (MAE) reduction of 6.0% compared to all baselines. In diabetic macular edema (DME), OphthaDT demonstrated competitive performance against all baselines while outperforming Random Forest and XGBoost by an average MAE reduction of 2.6% and 6.9%, respectively. Results reveal that OphthaDT's predictive advantage scales with trajectory complexity: whereas linear models remain effective for the more stable treatment responses of DME, OphthaDT's capacity is better suited for capturing the high longitudinal variability of nAMD. Finally, OphthaDT handles irregular sampling without imputation, positioning LLM-based clinical trajectory modeling as a methodology that could reduce patient burden and accelerate drug development.

The rapid proliferation of Internet of Medical Things (IoMT) devices introduces critical cybersecurity vulnerabilities in healthcare environments where resource-constrained medical devices operate under strict latency requirements and stringent data-privacy regulations. To address these challenges, this paper presents the Lightweight Digital Twin and Federated Reinforcement Learning (LDT-FRL) framework, a privacy-preserving defense architecture integrating four complementary mechanisms: a Temporal Attention Encoder (TAE) built on a GRU backbone with learned temporal self-attention for flow-level threat classification; lightweight LSTM-based Digital Twins trained on normal-class traffic to generate per-device anomaly scores that gate the TAE classifier through a learned sigmoid coupling; a Federated Proximal Policy Optimization (PPO) agent selecting among ALLOW, ISOLATE, and HONEYPOT_REDIRECT actions based on a seven-dimensional state; and an intelligent honeypot layer that converts redirected suspicious traffic into actionable threat intelligence. A federated aggregation strategy employing EMA-smoothed per-client validation losses as inverse-weighted FedAvg coefficients stabilizes global model updates under non-IID client distributions. Evaluated on CICDDoS 2019 and TON-IoT benchmarks, LDT-FRL achieves 99.66% and 99.95% test accuracy respectively, with macro-F1 scores of 0.9913 and 0.9995, converging 81% faster than the DTFL-CD baseline while attaining perfect F1=1.000 on the severely imbalanced MITM class. Explainability analysis via SHAP, LIME, Grad-CAM, and counterfactual methods confirms that the TAE focuses on semantically meaningful flow features, providing interpretable evidence for each defense decision.

Industrial automation is being transformed by digitalization and the increasing use of cyber-physical systems. Modern production environments require greater adaptability, faster reconfiguration, and more intuitive human-machine interaction. However, traditional rule-based systems rely on fixed logic and cannot autonomously adapt to changing conditions. Consequently, current automation systems lack a systematic approach for integrating adaptive and generalizable reasoning capabilities for interpreting, planning, and executing user tasks across dynamic environments and heterogeneous components. This dissertation proposes a three-layer framework that integrates large language models (LLMs), digital twins, and automation systems into an autonomous system. Autonomy is defined as a design property assigned to system components and enabled through LLM-based reasoning to achieve adaptive, goal-oriented behavior. The Task-Process-Service-Resource (TPSR) model is introduced to transform user tasks into executable processes. Four LLM roles are identified: process orchestration, service matching, digital resource generation, and agent-as-a-service. Five peer-reviewed studies develop and refine these concepts using the design science research methodology. Case studies and prototypes demonstrate adaptive task planning, event-driven control, simulation-based parameterization, and digital model generation. Results show high task executability, command correctness, and content-generation accuracy while reducing manual effort. The framework enables the integration of LLM-based reasoning into industrial automation systems and improves adaptability and usability. Limitations include dependence on accurate digital representations, the computational demands of LLMs, and the need for human intervention in safety-critical situations.

UAV-based pavement inspection can reduce the cost and risk of road-surface monitoring, but real-world deployment remains difficult when traffic, pedestrians, and temporary occlusions affect defect visibility. This paper presents a Unity-based digital twin framework for traffic-aware UAV pavement monitoring in open-traffic conditions. The proposed environment integrates procedurally generated road defects, dynamic traffic agents, autonomous UAV navigation, and a multitask YOLOv8n perception module for detecting road defects, pedestrians, and vehicles while classifying road-defect subtypes. After synthetic-domain fine-tuning, the perception model achieved 0.959 mAP@0.5 and 0.940 macro F1-score on a held-out synthetic test set generated from the simulator. The digital twin was then used to evaluate hover-and-recheck, micro-repositioning, and skip-and-revisit recovery strategies across different traffic densities and flight altitudes. Results show that flight altitude strongly affects inspection coverage, while recovery strategies introduce different trade-offs between coverage, mission duration, energy consumption, and revisit behaviour. These findings demonstrate that digital twins can support the development and evaluation of traffic-aware UAV inspection strategies before real-world deployment. The full implementation and trained models are available at https://github.com/EdwinTSalcedo/RDMO-DigitalTwin.

Building personalized cardiac electrophysiology (EP) digital twins requires identifying the appropriate model structure for each patient, not merely fitting parameters. Traditional methods rely on experts to manually prescribe hybrid physics-neural architectures, which requires deep domain expertise and does not transfer across patients. Recent works have applied large language models (LLMs) to generate or act as hybrid models. However, despite their promising generalization capacity, these LLM-based methods lack the structural priors needed for stable cardiac simulations. Hence, we propose LEADS, a framework that formulates cardiac EP domain knowledge as a structured action space and utilizes an LLM agent to discover hybrid models. The agent follows an iterative reasoning-and-action loop to select, combine, and refine hybrid models, whilst gradient descent handles parameter fitting. The proposed LEADS designs every candidate model towards physically grounded, interpretable, and numerically stable, while allowing open-ended architectural discovery. We validate LEADS on synthetic data with three ground-truth reaction models and on real cardiac EP data, demonstrating that it outperforms both human-designed hybrid models and other LLM-based hybrid modeling.

Surgical video question answering requires multi-step reasoning across semantic, spatial, and temporal dimensions. Existing methods architecturally compress videos into discrete token representations and couple visual perception with reasoning. This approach fragments continuous spatial-temporal relationships and has been shown to restrict multi-step reasoning capabilities. We introduce a reinforcement learning (RL) framework that trains large language models (LLMs) to decouple perception from reasoning by operating over digital twin representations constructed from surgical foundation models. Additionally, we introduce hierarchical representations across frame, temporal window, and procedure levels with probabilistic uncertainty estimates. Finally, we propose a novel reward that combines format validation with accuracy assessment through clinical plausibility evaluation and uncertainty-aware calibration for training. To demonstrate the capabilities of this approach, we introduce REAL-Colon-Reason, a colonoscopic benchmark with 2000 question-answer pairs across three complexity levels. We achieve state-of-the-art performance on REAL-Colon-Reason and two existing surgical VideoQA benchmarks REAL-Colon-VQA and EndoVis18-VQA.

A digital twin (DT) of a patient-specific heart offers significant potential in personalized medicine. However, its rapid and dynamic adaptation to an individual's live data and its predictive capability after adaptation remains central challenges. We examine this challenge from its two building blocks: DT formulation where mechanistic and data-driven models show competing merits and limitations, and DT optimization strategies that are largely driven by a reconstruction objective leading to un-identifiable models. We address both bottlenecks via HAPI -- an AI framework for building hybrid, adaptive, and predictive DTs with three key enablers. First, HAPI constructs a physics-integrated gray-box model in which an interpretable mechanistic backbone is augmented by a neural component that models its residual to the observed data. Second, rather than attempting to pre-encode all possible variations in a static hybrid model, HAPI enables rapid on-the-fly adaptation of the hybrid model to few-shot live data, achieved by feedforward meta-learners realizing amortized inference of both mechanistic and neural parameters of the hybrid model trained with predictive objectives. Finally, we show that this adaptivity corresponds to the construction of a conditional generative model (i.e., the hybrid DT) that endows it with theoretical identifiability and thus strong performance in predictive scenarios. We demonstrate the proof-of-concept of HAPI in cardiac electrophysiology using a hybrid monodomain model with mechanistic reaction kinetics and neural graph diffusion. Across synthetic and real-data studies, we show that HAPI's mechanistic-neural hybridization and predictive adaptation are critical for obtaining identifiable DTs with strong predictive and out-of-distribution capabilities.

Health digital twins (HDTs) promise patient-specific modeling and decision support but current approaches remain structurally fragmented: monolithic models that address a single organ or task lack cross-scale fidelity, while system-level twins lack generalizable architectural frameworks. We propose OmniBioTwin, a System-of-Twinned-Systems (SoTS) framework that organizes HDTs as modular computational entities coupled through explicit interaction operators within a multi-layer network architecture. The framework comprises seven coordinated layers - spanning data integration, autonomous twin modeling, cross-scale coupling, temporal synchronization, and human-in-the-loop decision support. We demonstrate OmniBioTwin by instantiating a multiscale twin for glucagon-like peptide-1 (GLP-1) signaling pathways in Alzheimer's disease, illustrating how molecular, cellular, and organ-level twins can be composed and coupled within a unified system.

Flexible robotic automation requires systems that interpret operator intent, verify physical feasibility, and recover from execution failures across both the planning and execution stages. This paper proposes an agentic neuro-symbolic framework for human-in-the-loop industrial robotics, in which LLMs are used for tasks that require language understanding or contextual reasoning, while all verification, sequencing, and execution remain deterministic. The framework adapts the Planner-Generator-Evaluator (PGE) harness pattern from software engineering into a Specifier-Designer-Inspector (SDI) architecture for industrial robotics, combined with LangGraph-based dynamic routing for failure recovery. A two-tier recovery mechanism addresses structure-level replanning through context-aware orchestration and execution-level geometric failures through deterministic recovery skills. A Unity3D digital twin supports human inspection, modification, and re-verification prior to physical execution. Evaluated on natural-language commands across multiple difficulty levels against ten baselines, the proposed method achieves the highest task success. Ablation results confirm that structured command expansion, symbolic verification, selective LLM routing, and recovery skills are each individually necessary.

Digital twins (DTs) allow the digitalization of road infrastructure inspection, though this is hindered by limited annotated data. This work exploits the relational nature of continuous asset condition monitoring to reformulate image-based defect detection as image difference classification (IDC) to reduce data reliance. This was evaluated in a case study on low-resource traffic sign inspection with different IDC classifiers using a newly-curated, high quality dataset. Results indicate that the instruction-based classifier outperforms encoder-based ones and gains from comparison with reference images. This shows that IDC can be an effective task modeling for tackling data constraints in infrastructure inspection and DT asset condition updating.

Theoretical heterogeneous catalysis promises rapid catalyst discovery, yet computational and machine-learning predictions often deviate from experiment and stay confined to narrow material families, for want of a faithful, condition-aware catalytic simulator. We present CatDT (Catalysis Digital Twin), a self-evolving multi-agent system that builds an autonomous digital twin of a working catalyst, unifying gas-solid and liquid-solid modeling. From only a bulk crystal and a natural-language reaction description, eight specialized agents and 27 scientific tools predict stable facets, reconstruct working surfaces, enumerate and rank reaction pathways, locate transition states, and compute kinetics in 5-30 min on a single GPU. Two innovations address the hardest steps: UniMech finds dominant pathways for novel materials at over $10^3\times$ lower cost than exhaustive enumeration by fusing agent-guided proposals with energy-cached graph search, and a memory-augmented reinforcement loop raises barrier-calculation success from 41% to 84% across 600 catalytic surfaces. Across seven gas-solid benchmarks -- stepped metals, single-atom catalysts, ordered intermetallics, vacancy-rich 2D sulfides and carbides, and a strong-metal--support-interaction (SMSI) interface -- every CatDT prediction lies within 0.5-2 times experiment over four orders of magnitude. For propane dehydrogenation, CatDT independently discovers non-precious candidates rivaling the Pt-based industrial benchmark, with a proposed Ni@ZrO$_2$ SMSI overlayer reaching a simulated TOF of $1.63~\text{s}^{-1}$ at $\sim$100% selectivity. More broadly, the decisive factor for a faithful catalyst digital twin -- or any multi-stage scientific simulator -- is not raw LLM capability but the engineered harness around it: deterministic tools, persistent memory, and verified self-improvement that compound across models, tools, and runs.

Alternatives to soil-based horticulture, such as hydroponics, have been developed to respond to food distribution concerns for dense urban centers. A new system was developed to track an individual lettuce plant's growth in a hydroponic environment, utilizing streams of measured information and available models to continuously update the growth trajectory estimates for a plant. These "digital twin" models were integrated into an operating hydroponic greenhouse, with custom horticultural and sensor hardware to grow and measure relevant information. To aid in updating model parameters, plant yield was continuously measured with a custom neural network, using RGB-D images of the plants as an input. The network, trained on a collected dataset of 1300 images, was able to estimate mass within 1.5 g of the ground-truth value. After integration into the custom system, digital twin growth projections could approximate future yield between one and four days in the future, maintaining around a 2 g forecasting error.

The evolution toward 6G wireless networks envisions a seamlessly intelligent, Open-RAN-enabled architecture where unmanned aerial vehicles (UAVs) play a pivotal role in extending coverage, enhancing resilience, and ensuring reliable connectivity for ground users deployment. However, efficiently managing spectrum and resources in such highly dynamic UAV-assisted environments remains a major challenge due to nonlinear system interactions, mobility-induced topology variations, and stringent latency and energy constraints. To address these challenges, we propose a digital twin (DT)-assisted adaptive deep reinforcement learning (DRL) framework that enables intelligent spectrum sharing and resource allocation across distributed ground users. The complex optimization problem is decomposed into UAV trajectory optimization using particle swarm optimization (PSO) and dynamic spectrum-power-association management via multi-agent DRL (MADRL). This hybrid DT-driven approach empowers intelligent, context-aware decision-making and adaptive coordination among UAVs. Extensive simulations demonstrate significant gains in spectral efficiency, data rates, and energy utilization, showcasing a transformative path toward self-evolving, autonomous 6G UAV and ground users (GUs) connectivity.

Wireless digital twins require repeated synchronization between a time-evolving physical scene and its digital counterpart under limited and time-varying communication resources. For perception-centric twins, pixel-domain transmission or uniformly protected bitstreams can be mismatched to the semantic state consumed by twin-side applications. This paper proposes TWIST, a closed-loop token synchronization framework for application-aware wireless digital twins. TWIST represents each physical observation as a token and synchronizes this state over a wireless link, rather than optimizing visual reconstruction. Token positions are grouped by task relevance and protected through mode-conditioned unequal error protection under low-, medium-, and high-synchronization modes. At the twin side, decoding confidence converts unreliable hard token decisions into erasures, which are restored by a completion model before updating the semantic twin state. The recovered state supports traffic-state inference and generates compact feedback statistics, including channel quality, receiver uncertainty, semantic drift, and application priority, for subsequent mode adaptation. Experiments on a dynamic road-scene digital-twin scenario show that TWIST improves traffic-state inference and semantic twin-state synchronization compared with fixed-mode and channel-only adaptation strategies, while reducing the average synchronization cost relative to always-high transmission.

We propose a framework for predicting the effects of mobility introduction measures using a human-flow digital twin. This digital twin incorporates a multi-agent simulator that can represent how visitors choose destinations depending on factors such as their current location and the attractiveness of spots. We extract data on how visitors selected destinations with respect to measured pre-intervention human-flow data, inter-spot distances, spot attractiveness, and travel volumes, and use these data to train each agent's decision model of this simulator. The trained decision model is a function that takes a visitor's current state and surrounding environmental information as input and outputs which spot the visitor will move toward next. By expressing mobility introduction measures as changes to inter-point distances or to spot attractiveness, the framework can reproduce human flows with mobility introduction in the multi-agent simulator and thereby quantify effects such as changes in visitor counts and circulation. We evaluated the proposed method using human-flow data measured with and without introducing mobility within Wakayama Castle Park in Japan. When reproducing flows with mobility introduction using a multi-layer perceptron decision model, the cosine similarity of the spatial population distribution exceeded 0.7, confirming that the approach can replicate the flow changes caused by the mobility introduction.

Digital twins (DTs) rely on continuous synchronization between physical systems and their virtual counterparts through online parameter estimation under uncertainty. In many practical settings, however, this task is challenged by low observability, weak excitation, nonlinear dynamics, and noisy or biased measurements. In this work, we develop a new mathematical framework that integrates Weighted Flow Matching (WFM) generative modeling with physics-informed nonlinear filtering to enhance parameter estimation in DTs. WFM relies on dynamic reweighting of training samples, which guides the generative model toward parameter regimes most informative of the evolving system state. This generative component is tightly coupled with a physics-informed filtering architecture based on the Unscented Kalman Filter (UKF), yielding a unified DT framework that combines data-driven probability transport with physically consistent state and parameter estimation. The effectiveness of the new integrated framework is demonstrated within a spacecraft DT architecture, where stable moment of inertia estimation is achieved under uncertain and noisy sensing, with significant performance improvements over established approaches such as Extended Kalman Filtering (EKF) and Ensemble Kalman Filtering (EnKF). These results highlight the potential of weighted generative modeling as a core mechanism for real-time DT synchronization in operational and mission-critical systems.

Semantic communication has emerged as a promising paradigm for enabling goal-oriented networking. However, most existing semantic communication solutions are tailored to one-shot tasks and optimize instantaneous performance. Hence, they cannot be used to support closed-loop dynamic systems with physical artificial intelligence (AI), in which the transmitted semantics affect not only the current inference outcome but also future control actions, state evolution, and ultimately long-horizon task performance. To address this gap, this paper investigates goal-oriented semantic communications for physical AI systems with closed-loop sensing-communication-inference-control. In particular, the problem of semantic communications is formulated as a long-term return-per-bit maximization under wireless bit-budget constraints while capturing both control efficiency and communication efficiency. To solve this problem, a novel causal information value (CIV) metric is introduced to evaluate the marginal contribution of each semantic token to the expected long-term return by transmission interventions. Then, a world-model-enabled causal digital twin (WM-CDT) framework is proposed to capture the dynamics of closed-loop physical AI systems and enable counterfactual reasoning for long-horizon imagined rollouts. Based on these imagined rollouts, an actor-critic policy is trained for long-horizon agent control with high data efficiency, while the semantic token selector is trained through CIV-per-bit evaluation. Extensive simulations on an AirSim-Sionna-based unmanned aerial vehicle (UAV) navigation simulator show that the proposed WM-CDT framework achieves significant improvement in return-per-kbit and navigation success rate compared to existing reinforcement learning solutions.

Single-arm trials are an important study design for evaluating drug efficacy and safety without enrolling patients into a control arm. Although they do not provide the gold-standard evidence of randomized controlled trials, they are increasingly used in clinical development as they offer an efficient, ethical, and practical alternative. A wide variety of approaches can be used to construct control comparators and estimate treatment effects, from fixed comparators informed by clinical knowledge to data-based and model-based patient-level comparators, also known as synthetic controls. Powerful and flexible machine learning models can allow outcome-model-based synthetic controls to overcome key limitations of direct data-based approaches, yield more robust estimates of treatment effects, and provide a principled way to incorporate corrections or encode additional assumptions when external data are not directly comparable. In this work, we argue that outcome-model-based synthetic control arms are an important tool for single-arm trials. We focus on digital twins, personalized predictions of disease progression generated from machine learning models trained on historical datasets, which naturally leverage these flexible approaches. We review doubly robust estimators, present power and sample size formulas, and discuss trade-offs in selecting historical data for training and analysis. We also outline practical considerations for deploying digital twins within the framework of recent FDA draft guidance on the use of artificial intelligence in drug development. Finally, we reanalyze data from trials in amyotrophic lateral sclerosis and Huntington's disease to demonstrate the proposed methods.

Digital twins (DTs) for urban transportation systems have gained increasing attention; however, their systematic evaluation in safety-critical scenarios remains limited. This paper presents a multi-pedestrian safety warning system at urban intersections enabled by a tightly coupled physical-digital twin framework. Built upon the COSMOS city-scale wireless testbed in New York City, the proposed system integrates camera and ultra-wideband (UWB), edge-cloud computing, predictive trajectory modeling, and MQTT-based communication to deliver real-time safety alerts to vulnerable road users (VRUs). The system is evaluated through both field deployment and virtual reality (VR) experiments. Results demonstrate high warning generation accuracy, localization accuracy, efficient end-to-end latency under different model configurations, and significant reductions in user response time when warnings are issued. The proposed DT framework provides a scalable, modular, and generalizable solution for real-time multi-pedestrian safety enhancement at complex urban intersections.

Despite the central role of sensor-derived measurements such as imaging traits and plasma biomarkers in biomedical research and clinical practice, existing generative models for disease prediction largely depend on event-level representations from hospital and registry data. Given the multi-factorial nature of human disease, the absence of explicit modeling of social determinants of health (SDoH), even in the limited form of ICD-coded proxies (chapters Z and V--Y in ICD-10), limits the capacity for personalized disease modeling and clinical decision support. To address this limitation, we propose a generative model with ICD-coded proxies of SDoH for \textit{in silico} modeling of disease reasoning, a conditioned latent diffusion framework that establishes the connection between multi-organ sensor data with tokenized healthcare events. Specifically, we introduce a novel geometric diffusion model to characterize the temporal evolution of complex data representation such as brain networks (region-to-region connectivity encoded in a graph), in parallel with diffusion models for tabular data from other organ systems. Together, we integrate the generative model with digitalized SDoH proxies (coined \modelname{}) for simulated intervention and reasoning of future disease trajectories. We conduct extensive experiments on the UK Biobank (UKB) dataset, which contains organ-specific imaging traits, including brain (44,834), heart (23,987), liver (28,722), and kidney (32,155), along with nearly 500k medical history sequences (age range: 25$\sim$89 years). Our \modelname{} achieves significant improvements over state-of-the-art human disease autoregressive models and imaging trait generative baselines.

Physics-based digital twins aim to predict the dynamics of real-world objects under interaction, enabling real-to-sim-to-real applications in robotics. Current approaches reconstruct such twins as explicit physical models (such as spring-mass systems) to predict the dynamics, but the resulting models often inherit the resolution of the visual reconstruction rather than being reduced to the physical complexity required to reproduce task-relevant dynamics. This mismatch introduces redundant topology, making repeated forward-dynamics rollouts unnecessarily expensive. To address this challenge, we present PhySPRING, an fully differentiable GNN-based method to reduce complexity in spring--mass digital twins. PhySPRING jointly learns a hierarchy of coarsened graph topologies and their mechanical parameters from observations. At each reduction level, PhySPRING merges nodes with similar learned dynamic responses to optimize the topology, while maintaining every reduced layer as an explicit spring--mass system. On the PhysTwin benchmark, PhySPRING improves dense reconstruction and prediction accuracy over PhysTwin, while reduced models retain stable physical and visual fidelity with up to a 2.30 times speed-up. We further demonstrate the effectiveness of PhySPRING in a Real2Sim robot policy-evaluation pipeline, where the reduced models are substituted zero-shot into ACT and $π_0$ evaluations, maintaining comparable manipulation success rates across downsampling levels while improving action-sampling effectiveness. Together, PhySPRING enables efficient and structure-preserving spring--mass reduction without sacrificing fidelity or robotic utility.

Bayesian model calibration is central to digital twins and computer experiments, as it aligns model outputs with field observations by estimating calibration parameters and correcting systematic model bias. Classical Bayesian calibration introduces latent parameters and a discrepancy function to model bias, but suffers from parameter--discrepancy confounding and is typically formulated as an offline procedure under a stationary data-generating assumption. These limitations are restrictive in modern digital twin applications, where systems evolve over time and may exhibit gradual drift and abrupt regime shifts. While data assimilation methods enable sequential updates, they generally do not explicitly model systematic bias and are less effective under abrupt changes. We propose Bayesian Recursive Projected Calibration (BRPC), an online Bayesian calibration framework for streaming data under simulator mismatch and nonstationarity. BRPC extends projected calibration to the online setting by separating a discrepancy-free particle update for calibration parameters from a conditional Gaussian process update for discrepancy, preserving identifiability while enabling bias-aware adaptation under gradual system evolution. To handle abrupt changes, BRPC is integrated with restart mechanisms that detect regime shifts and reset the calibration process. We establish theoretical guarantees for both components, including tracking performance under gradual evolution and false-alarm and detection behavior for restart mechanisms. Empirical studies on synthetic and plant-simulation benchmarks show that BRPC improves calibration accuracy under gradual changes, while restart-augmented BRPC further improves robustness and predictive performance under abrupt regime shifts compared to sliding-window Bayesian calibration and data assimilation baselines.

Real-time supervisory control of thermal energy distribution systems requires digital twins that are accurate, interpretable, and uncertainty-aware, yet remain data and computationally efficient. High-fidelity simulations alone are costly, while purely data-driven surrogates often lack robustness. To address these challenges, this work proposes an active learning (AL) framework that couples system-level Modelica simulations with four simpler physics-informed and data-driven surrogate modeling approaches: deterministic Sparse Identification of Nonlinear Dynamics with Control (SINDyC), its probabilistic multivariate-Gaussian extension (MvG-SINDyC), feedforward neural network (FNN), and gated recurrent unit (GRU) network. Tailored to each surrogate, model-specific AL query strategies are employed, including Mahalanobis-distance sampling in coefficient space for MvG-SINDyC and error-based sampling in prediction space for SINDyC, FNN, and GRU, allowing the learning process to prioritize dynamically informative trajectories. The proposed approach is demonstrated on the glycol heat exchanger (GHX) subsystem of the Thermal Energy Distribution System (TEDS) at Idaho National Laboratory. Across key GHX outputs--the bypass mass flow rate $\dot{m}_{\mathrm{GHX}}$ and heat transfer rate $Q_{\mathrm{GHX}}$-the AL framework achieves comparable predictive accuracy using as few as one-fifth of the simulation trajectories required by random sampling. Among the evaluated surrogates, the GRU achieves the highest predictive fidelity, while SINDyC remains the most computationally efficient and interpretable. The probabilistic MvG-SINDyC surrogate further enables uncertainty quantification and exhibits the largest computational gains under AL.

Network digital twins (NDTs) are transforming network management by offering precise virtual replicas of physical network systems. However, their reliance on diverse and sensitive data introduces significant challenges related to data management, regulatory compliance, and user privacy. In scenarios where selective data removal is necessary, such as device deactivation, network reconfiguration, or regulatory compliance, traditional approaches often fall short of preserving the integrity of the twin model. To address this gap, we introduce a network digital untwinning framework that enables the targeted removal of deprecated NDT contributions while maintaining model integrity. Our approach comprises two complementary components: Single Request Untwinning (\algO) and Parallel Request Untwinning (\algM) mechanisms. \algO leverages connectivity metrics based on geographical proximity, data distribution, and network-level attributes to identify and remove the target NDT along with its propagating influence. This is achieved through an optimally selected rollback checkpoint augmented with injected Gaussian noise, followed by a precise remapping phase. \algM extends this mechanism to efficiently handle multiple removal requests by clustering NDTs with similar attributes and performing a coordinated rollback and untwinning schedule. We provide theoretical guarantees on model indistinguishability from scratch-built twins, and validate the framework through extensive experiments on real-world traffic data, demonstrating its effectiveness and operational efficiency.

This article outlines a new framework of traffic light optimization through a digital twin of the transport infrastructure, managed by agentic AI to ensure real-time autonomous decisions. The framework relies on physical sensors and edge computing to measure real-time traffic information and simulate traffic flow in a constantly updated digital twin. The traffic light is automatically controlled through the digital twin according to traffic congestion, travel delay and traffic patterns. This approach is implemented as a three-layer system: perception, conceptualization and action. The perception layer receives data on physical systems; the conceptualization layer uses LangChain to process the data; and the action layer links to the Model Context Protocol (MCP) and traffic management APIs to implement optimised traffic signal control algorithms. The results show that the framework minimizes waiting time at traffic lights and positively affects the effectiveness of the entire traffic flow, which is better than the fixed-time and reinforcement learning-based baselines.

Here, we explore the problem of error propagation mitigation in modular digital twins as a sequential decision process. Building on a companion study that used a Hidden Markov Model (HMM) to infer latent error regimes from surrogate-physics residuals, we develop a Markov Decision Process (MDP) in which the inferred regimes serve as states, corrective interventions serve as actions, and a scalar reward that takes into consideration the cost-benefit tradeoff between system fidelity and maintenance expense. The baseline transition matrix is extracted from the HMM-learned parameters. We then extend the formulation to a Partially Observable MDP (POMDP) that accounts for the imperfect nature of regime classification by maintaining a belief distribution updated via Bayesian filtering, with the HMM confusion matrix serving as the observation model. Both formulations are solved via dynamic programming and validated through Gillespie stochastic simulation. We then benchmark two model-free reinforcement learning algorithms, Q-learning and REINFORCE, to assess whether effective policies can be learned without explicit model knowledge. A systematic comparison of different intervention policies demonstrates that the MDP policy achieves the highest cumulative reward and fraction of time in nominal operation, while the POMDP recovers approximately 95% of MDP performance under realistic observation noise. Sensitivity analyses across observation quality, repair probability, and discount factor confirm the robustness of these conclusions, and the major gaps in the policy hierarchy are statistically significant at $p < 0.001$. The gap between MDP and POMDP performance quantifies the value of information providing a principled criterion for investing in improved classification accuracy.

Digital twins of natural systems must remain aligned with physical systems that evolve over time, are only partially observed, and are typically modeled by mechanistic simulators whose parameters cannot be measured directly. In such settings, model adaptation is naturally posed as a simulation-based inference problem. However, sparse and indirect observations often fail to identify a unique and optimal calibration, leaving several simulator parameterizations compatible with the available evidence. This article presents a GFlowNet-based approach to model adaptation for digital twins of natural systems. We formulate adaptation as a generative modeling problem over complete simulator configurations, so that plausible parameterizations can be sampled with probability proportional to a reward derived from agreement between simulated and observed behavior. Using a controlled environment agriculture case study based on a mechanistic tomato model, we show that the learned policy recovers dominant regions of the adaptation landscape, retrieves strong calibration hypotheses, and preserves multiple plausible configurations under uncertainty.

Network change validation remains a critical yet predominantly manual, time-consuming, and error-prone process in modern network operations. While formal network verification has made substantial progress in proving correctness properties, it is typically applied in offline, pre-deployment settings and faces challenges in accommodating continuous changes and validating live production behavior. Current operational approaches typically involve scattered testing tools, resulting in partial coverage and errors that surface only after deployment. In this paper, we present Aether, a novel approach that integrates Generative Agentic AI with a multi-functional Network Digital Twin to automate and streamline network change validation workflows. It features an agentic architecture with five specialized Network Operations AI agents that collaboratively handle the change validation lifecycle from intent analysis to network verification and testing. Aether agents use a unified Network Digital Twin integrating modeling, simulation, and emulation to maintain a consistent, up-to-date network view for verification and testing. By orchestrating agent collaboration atop this digital twin, Aether enables automated, rapid network change validation while reducing manual effort, minimizing errors, and improving operational agility and cost-effectiveness. We evaluate Aether over synthetic network change scenarios covering main classes of network changes and on past incidents from a major ISP operational network, demonstrating promising results in error detection (100%), diagnostic coverage (92-96%), and speed (6-7 minutes) over traditional methods.

While traditional AI and data-driven facilities management approaches have improved building operational efficiency, they remain constrained by centralized organizational structures that are vulnerable to cyber attacks, limited contextual understanding, and decision-making processes that exclude key stakeholders from governance. This paper introduces a novel AI- and data-driven distributed governance framework for smart building management that integrates decentralized autonomous organizations (DAOs), digital twins, large language models (LLMs), and blockchain technology. The framework enables transparent collective decision-making through a DAO governance platform, implements data-driven management using IoT and digital twins, incorporates LLM-based virtual assistants for enhanced decision support, and utilizes blockchain for secure building automation. A full-stack decentralized application was developed to facilitate user interaction with these integrated components. The system was evaluated for cost efficiency, scalability, data security, and usability using the System Usability Scale (SUS). Expert interviews were also conducted to assess its practical benefits and implementation challenges.

Large language models (LLMs) act as digital twins for human respondents, yet their psychometric comparability remains uncertain. We propose a construct validity framework spanning construct representation and the nomothetic span, benchmarking models against human gold standards. Across studies, digital twins achieved high aggregate-level accuracy and profile correlations, but showed attenuated item-level correlations. In word association tests, LLM networks exhibited humanlike small-world structure and theory-consistent communities, yet diverged lexically and in local structure. In decision-making and contextualized tasks, they under-reproduced heuristic biases, demonstrating normative rationality, compressed variance, and limited temporal sensitivity. Feature-rich and trait relevant conditioning improved Big Five personality prediction and nomothetic-span alignment, but network invariance remained limited, with partial configural solutions and persistent loading differences. In cross-language free-text tasks in English and Chinese, feature-rich digital twins better approximated construct-level narrative content, but linguistic and idiographic differences persisted. These findings clarify that digital twins are most useful within validated boundaries, where the construct, task and level of inference align with evidence from human data.

This work shows how adaptivity can enhance value realization of digital twins in civil engineering. We focus on adapting the state transition models within digital twins represented through probabilistic graphical models. The bi-directional interaction between the physical and virtual domains is modeled using dynamic Bayesian networks. By treating state transition probabilities as random variables endowed with conjugate priors, we enable hierarchical online learning of transition dynamics from a state to another through effortless Bayesian updates. We provide the mathematical framework to account for a larger class of distributions with respect to the current literature on digital twins. To compute dynamic policies with precision updates we solve parametric Markov decision processes through reinforcement learning. The proposed adaptive digital twin framework enjoys enhanced personalization, increased robustness, and improved cost-effectiveness. We assess our approach on a case study involving structural health monitoring and maintenance planning of a railway bridge.