Wearable Devices

Human Activity Recognition (HAR) from wearable sensors supports applications in healthcare, rehabilitation, fitness tracking, and smart environments. Yet, existing deep learning approaches require dataset-specific training, large labeled corpora, and repeated adaptation to new sensor settings or activity taxonomies. Retrieval-Augmented Generation for Human Activity Recognition (RAG-HAR) addresses this by framing HAR as a training-free, retrieval-augmented task, in which statistical descriptions of sensor windows are used to retrieve similar labeled examples that guide LLM-based classification. We introduce RAG-HAR+, a retrieval-first and cost-optimized extension that strengthens retrieval while reducing dependence on LLM-based inference. RAG-HAR+ uses an offline Retrieval Designer Agent to design dataset-specific feature groups from a diverse pool of motion descriptors, enabling sensor windows to be compared using features better aligned with dataset-specific activity patterns. During inference, RAG-HAR+ uses majority voting over retrieved neighbors for samples with strong retrieval evidence and defers only uncertain cases to an LLM-based Ambiguity Resolver Agent. Across six HAR benchmarks, RAG-HAR+ maintains competitive or improved performance while reducing LLM usage, token consumption, and inference time. We further extend the RAG-HAR mobile prototype to demonstrate the practical feasibility of retrieval-first, LLM-assisted HAR in mobile sensing scenarios.

Remote photoplethysmography (rPPG) enables non-contact heart-rate estimation from facial videos, but its weak physiological signal is easily corrupted by motion, illumination changes, occlusion, skin-appearance variation, and device noise. Existing rPPG methods typically rely on a single model to directly predict heart rate or recover pulse waveforms, while different strong estimators may produce conflicting yet individually plausible candidates for the same video. To resolve these conflicts, we propose PhysAgent, an inference-time multi-agent candidate-verification framework. Unlike direct prediction approaches, PhysAgent neither trains a new base rPPG model nor asks Multimodal Large Language Models (MLLMs) to output heart rate directly. In contrast, it treats outputs from multiple base estimators as physiological hypotheses to be verified and uses a lightweight 4B MLLM, Qwen3-VL-4B, to drive multi-agent reasoning over video conditions, signal reliability, and candidate disagreement. A deterministic physiological verifier checks the fusion proposal, and a reproducible numerical fusion process produces the final heart rate. Experimental results on multiple public rPPG benchmarks show that PhysAgent improves fusion stability and reliability across different datasets and source-domain settings, while avoiding the irreproducibility and physiological inconsistency of direct MLLM prediction or unconstrained ensemble fusion. The code will be released soon.

Sleep occupies roughly one-third of human life, yet many aspects of its physiology remain poorly understood. Large polysomnography (PSG) datasets offer new opportunities to study sleep and its links to disease, but extracting insight from these recordings requires substantial expert effort and remains difficult for general-purpose AI systems. We developed AI Sleep Co-Scientist, an expert-guided environment in which human scientists direct specialist agents for hypothesis development, signal preprocessing, and statistical analysis, reviewing intermediate outputs. Each reported result is linked to the executable code that produced it. Across four cohorts of approximately 124,000 PSG recordings and more than 50 TB of raw signals, we conducted five case studies spanning how sleep physiology relates to future disease, how it distinguishes clinical phenotypes, and how sleep is organized and regulated. Diminished network-level physiological coupling during sleep was associated with incident Parkinson's disease (HR 1.48) and Alzheimer's disease (HR 1.38). A physiologically structured late-fusion sleep-age model outperformed an unconstrained early-fusion approach, and its age residual was associated with incident disease across multiple organ systems. Arousal dynamics characterized comorbid insomnia and sleep apnoea as an intermediate phenotype skewed towards obstructive sleep apnoea, distinguished by prolonged post-arousal wakefulness. Rapid eye movement (REM) bout duration tracked preceding non-REM sleep more closely than intervening wakefulness. Transient-oscillation analysis identified a fast-sigma deficit and excess centrofrontal theta activity in narcolepsy type 1. Together, these findings connect sleep to disease risk, clinical classification, and its own regulation, and show how agentic AI can support large-scale, multimodal discovery.

In this paper, we propose the MAEConformer, a novel self-supervised learning framework that combines the Conformer architecture with the Masked Autoencoder (MAE) paradigm for large-scale representation learning from unlabelled electroencephalography (EEG) and heart rate variability (HRV) signals. By integrating convolutional operations with Transformer-based self-attention, MAEConformer effectively captures both local temporal patterns and long-range contextual dependencies in physiological time series. To enhance reconstruction fidelity and representation quality, a multi-resolution short-time Fourier transform (MR-STFT) loss is incorporated alongside the reconstruction objective, enabling the model to jointly learn temporal and spectral characteristics across multiple scales. Modality-specific EEG and HRV MAEConformer models were pretrained on 6,030h and 4,868h of unlabelled recordings, respectively, and subsequently transferred to expert-annotated downstream tasks. Experimental results demonstrate that the learned representations provide strong transferability and data efficiency. In EEG-based hypoxic ischemic encephalopathy (HIE) severity classification, the pretrained MAE-EEG model achieved test AUCs of 97.19% and 96.56% for binary and four-class classification tasks, respectively, outperforming a range of state-of-the-art supervised and self-supervised baselines. On the HRV-based HIE severity classification task, MAE-HRV achieved a test AUC of 82.42%, surpassing both self-supervised Transformer-based and supervised convolutional baselines. These findings demonstrate the effectiveness of MAEConformer for learning robust and transferable representations across multiple physiological modalities.

Continuous cuffless blood pressure (BP) monitoring is essential for connected health systems and wearable devices, enabling early detection, longitudinal tracking, and personalized management of cardiovascular disease. Many prior approaches attempt to estimate BP indirectly by reconstructing electrocardiography (ECG) from photoplethysmography (PPG), assuming ECG provides a stronger physiological link to BP. However, ECG sensing is less accessible in wearable settings and may introduce unnecessary complexity. In this work, we first perform a large-scale physiological correlation analysis on the MIMIC-III waveform database, revealing that PPG exhibits substantially stronger coupling with arterial blood pressure (ABP) ($|r|=0.247$, $p<0.001$) than ECG does ($r=0.018$, $p=0.187$), challenging the assumption that ECG provides a superior intermediate representation. Motivated by this insight, we conduct a systematic comparison between direct PPG-to-BP prediction and ECG-mediated pipelines using multiple state-of-the-art deep learning models. Across 1.74M segments from 3,127 patients, direct PPG-to-BP prediction achieves British Hypertension Society Grade A performance ($\mathrm{MAE}_{\mathrm{SBP}} = 4.82 mmHg$, $\mathrm{MAE}_{\mathrm{DBP}} = 4.31 mmHg$), outperforming all ECG-mediated approaches, which achieve only Grade B accuracy. Our findings suggest that accurate continuous BP monitoring can be achieved directly from wearable PPG signals, enabling simpler, more efficient pipelines for real-world connected health systems.

Automated sleep staging is increasingly used in large-scale studies to derive sleep-architecture endpoints: total sleep time, REM latency, sleep efficiency, and bout-duration statistics. Deep learning models achieve epoch-level accuracy approaching inter-rater agreement, yet often produce hypnograms that violate physiological invariants, such as rare transitions (e.g., direct Wake -> REM) or excessively fragmented sequences. Such violations can bias downstream sleep metrics, regardless of overall accuracy. We propose StageGuard, a plug-and-play, backbone-agnostic structured-inference framework that wraps any neural sleep-staging backbone with physiology-informed priors. StageGuard combines (1) a differentiable soft transition penalty that discourages physiologically rare transitions during training, and (2) a semi-Markov constrained decoder with a duration-augmented state space that jointly enforces transition penalties and minimum bout durations at inference. Unlike hard-prohibition methods, it admits rare transitions when emission evidence is overwhelming, leaving informative pathological events recoverable rather than blocked. StageGuard constrains staging outputs to satisfy known physiological priors rather than modeling sleep generatively. We quantify the validity gap using transition-violation rate (TVR) and fragmentation index (FI) and demonstrate that, across six backbones and four datasets, StageGuard reduces TVR to physiologically plausible levels and lowers FI by 56-62%, while maintaining or slightly improving classification accuracy. Crucially, improved constraint satisfaction translates into 59-79% lower error on derived sleep-architecture statistics not directly optimized by the method, and recovers the direction and effect size of expert-defined subgroup differences (OSA severity, age) more faithfully than the unconstrained baseline.

Hand gesture recognition via surface electromyography (sEMG) is fundamental to prosthetic control. In this field, deep learning approaches have become the gold standard. However, current architectures struggle to scale; model performance typically decreases as the number of hand movements increases. Performance degradation is tied to the increased statistical complexity of decoding expanded gesture sets and compounded by the limitations of state-of-the-art methods, which primarily rely on low-latency unimodal convolutional architectures. Convolutions operate locally, limiting model's ability to capture long-range sequential patterns. Unimodal setups cannot leverage complementary information from coordinated signals characterizing movement execution, such as inertial and eye-tracking data. These limitations motivate architectures that integrate local and global features across multimodal physiological sequences. To bridge this gap, this study introduces EMG-CrossFormer, an end-to-end hybrid convolutional-transformer for seamless multimodal integration. EMG-CrossFormer combines representations from an arbitrary number of unimodal encoders through cascaded cross-attention fusion layers, and decodes the fused representations using learnable gesture queries. EMG-CrossFormer was evaluated on four NinaPro datasets (DB2, DB3, DB7, and DB10) and benchmarked against six state-of-the-art models using an increasing number of modalities. Using only sEMG, EMG-CrossFormer achieved mean accuracies of 72.33%, 52.48%, 79.16%, and 73.49% on DB2, DB3, DB7, and DB10, respectively. Incorporating inertial signals improved performance to 90.66%, 80.40%, 92.79%, and 92.06%. These results show that joint local-global feature modeling improves sEMG-only decoding and that multimodal fusion substantially amplifies this benefit, underscoring the value of both design principles for complex hand gesture recognition.

Talking-face (TF) deepfake generation synthesizes photore- alistic facial video from a static source image and an au- dio signal, producing forgeries that current image-based detectors consistently fail to identify. Unlike face-swap ma- nipulation, TF synthesis has no underlying real video from which to inherit physiological characteristics, making re- mote photoplethysmography (rPPG) a uniquely motivated detection modality for this forgery category. We propose a detection framework that extracts per-video rPPG wave- forms via RhythmFormer and trains a suite of lightweight classifiers to distinguish real from synthesized physiologi- cal signals. Evaluated on the TF subset of Celeb-DF++ un- der a strict subject-independent protocol, where test identi- ties are completely separated from training identities, our 1D ResNet achieves an AUC of 0.806 and EER of 27.8%, placing it within 2.4 points of the best published general- purpose detector (Effort, ICML 2025) while operating ex- clusively on the physiological channel. We document a con- trolled reproduction study of DeepFakesON-Phys, the rep- resentative prior rPPG detector, demonstrating degrada- tion from AUC 0.999 on legacy face-swap data to 0.622 on the TF subset of Celeb-DF++. We further show that detec- tion difficulty is strongly method-dependent: AUC ranges from 0.985 (Real3DPortrait) to 0.690 (IP-LAP) across the seven TF generators, with the ranking remaining perfectly stable across all evaluation protocols. This spread reflects an interpretable physiological property of each generator rather than evaluation noise, and constitutes the primary theoretical contribution of the work.

Traditional approaches to wearable health signal analysis, such as smartwatches, are constrained by rigid analytical frameworks and limited personalisation. The emergence of LLM agents creates a new opportunity for Personal Health Agentic Analysis, where health insights can be generated adaptively and in context. However, currently there is no open-source locally deployable platform capable of processing personal health data in real time while preserving privacy. We present HiMe, a locally deployable, privacy-first agent platform that is fully compatible with real-time health data ecosystems across a wide range of wearable devices. HiMe is guided by three design principles. The database is treated as a first-class component. Effectiveness and efficiency are jointly optimised to achieve a low-cost Pareto-optimal balance. Data are processed in real time while the user is modelled over the long term. Together, these principles make it practical for individuals to harness Personal Health Agents for continuous, personalised health monitoring for better wellbeing.

Short-term Heart Rate Variability (HRV) forecasting could provide clinicians with actionable lead time for detecting autonomic dysfunction and adverse cardiac events. Consumer wearable devices generate fragmented, artifact-rich HRV signals that challenge conventional forecasting approaches. In this study, we evaluated the forecasting ability of three Time Series Foundation Models (TSFMs), TimesFM, Chronos, and MOIRAI, against traditional baselines (Mean, Exponential Smoothing, and Exponentially Weighted Moving Average) on real-world wearable data collected from 49 healthy individuals. To address data fragmentation, we introduce a variability-preserving imputation method that augments linear interpolation with locally adaptive stochastic noise, retaining physiological dynamics essential for accurate forecasting. The results show that TSFMs outperformed all baselines without fine-tuning, achieving average Mean Absolute Scaled Error (MASE) between 0.81 and 0.87 across TSFMs and both context lengths (32 and 64 time steps), with Chronos and TimesFM as the top models, though MOIRAI showed limited gains over baselines. With up to a 2-hour forecast horizon, the results establish a baseline for TSFMs' performance on a real-world dataset, highlighting domain-specific fine-tuning as a promising direction for clinical deployment.

This Good Practice Guide presents work done in the QUMPHY project (Uncertainty quantification for machine learning models applied to photoplethysmography signals) that considered both machine learning and uncertainty quantification for problems which used photoplethysmography (PPG) signals from wearable devices as input. It provides high-level guidance on what types of machine learning model might be used and how different models compare when applied to both regression and classification tasks. It provides guidance on the implementation of different methods for uncertainty quantification, covering both model-dependent and model-independent techniques, and on the validation of the results provided by those methods. It also describes six benchmark problems together with pointers to different benchmark datasets for each problem. Software is described that can assist practitioners in implementing the methods described herein and there is a brief consideration of ethical issues. It concludes with a summary and recommendations.

Reliable and continuous human tracking is essential for natural human-robot interaction, particularly for companion robots. However, many existing approaches rely on wearable tags or fixed cameras with limited fields of view, which reduces system flexibility and often causes tracking failures when the target moves outside the sensing range. In this paper, we present a human tracking approach based on a gimbal-mounted camera integrated into a mobile robot. By actively controlling the gimbal mechanism, the camera can dynamically adjust its viewing direction to maintain the target within the field of view, even under substantial relative motion between the robot and the human. Furthermore, a continual learning strategy is applied to the person re-identification (ReID) task to adapt to changes in appearance and environmental conditions during long-term tracking. Experimental results demonstrate that the proposed system significantly improves the stability and continuity of human tracking, enables real-time re-identification, and provides responsive feedback for reliable tracking of human motion from walking to running. User studies further indicate that the proposed approach enhances user comfort by eliminating the need for wearable tags.

Automatic pain localization, which involves identifying the anatomical origin of pain from peripheral physiological signals without patient self-report, is a clinically critical but largely unaddressed problem, particularly for non-verbal patients. This paper presents a systematic comparison of classical feature engineering and deep sequence learning for subject-independent three-class pain localization using the AI4Pain 2026 Challenge dataset, which comprises four synchronously recorded wearable modalities: electrodermal activity, blood volume pulse, respiration, and peripheral oxygen saturation recorded from 65 participants under controlled TENS-induced pain. A 115-dimensional hand-crafted feature set spanning time-domain, frequency-domain, modality-specific, and cross-modal descriptors is benchmarked against end-to-end deep architectures. Extremely Randomized Trees achieves the highest macro-F1 of 0.539, outperforming the best deep model by 7.4 percentage points, with EDA spectral features emerging as the dominant discriminators. A consistent 26-point gap between pain detection (F1,=,0.815) and localization (F1,=,0.552) across all models points to a fundamental ceiling imposed by the anatomical diffuseness of peripheral autonomic pathways at 10-second resolution.

Background: Clinical decision support systems degrade silently as treatment protocols evolve, yet standard adaptation methods treat models as monolithic blocks, unable to distinguish stable patient physiology from shifting institutional practice. Methods: We propose an adaptive clinical intelligence architecture for ICU intervention prediction that structurally decouples physiological from treatment representations, confining parameter updates to the treatment stream upon a dual distributional and accuracy trigger. Automated audit logs record which treatment features drove each adaptation event and how their importance shifted. At inference, an attribution-driven Temporal RAG module grounds each prediction in patient-specific, era-matched PubMed evidence anchored to the patient's dominant physiological features. Experiments used 84,792 MIMIC-IV stays (2008-2022) under strict chronological split. Results: Drift localised entirely to the treatment stream, validating the structural prior. Selective adaptation improved vasopressor and septic shock discrimination and calibration over the static source model. A fully retrained baseline yielded marginally higher aggregate discrimination but missed 26 septic shock cases the framework correctly identified, with none in the reverse direction; retrieval consistency with the pre-adaptation source model was preserved by the framework but degraded substantially in the retrained baseline. Conclusions: Structurally constraining adaptation to drifting components while preserving stable physiological representations enables clinical AI to evolve with practice without distorting learned patient biology. This architecture offers a template for governable, interpretable deployment of adaptive models in high-stakes clinical environments.

Hearables are wearable computers worn on the ear. Bone conduction microphones are used with air conduction microphones in hearables for multimodal speech enhancement in noisy conditions. Despite this potential, current models largely fail to explore how jointly reducing sampling bit resolution and sampling frequency in analog-to-digital converters (ADCs) of hearables impacts both power usage and audio quality. Furthermore, current frameworks cannot do sub-Nyquist sampling in hearables because they lack a method to reconstruct wideband signals from narrowband components. We therefore propose CAPS, which (i) intentionally employs sub-Nyquist sampling and low bit resolution in ADCs, achieving a 3.3x reduction in power consumption in hearables, and (ii) supports streaming operation on mobile platforms with an inference time of 1.36 ms and a memory footprint of 11.04 MB. CAPS ensures robust speech intelligibility in real-world settings, bridging the gap between efficiency and power savings.

Deep remote photoplethysmography (rPPG) attains sub-bpm heart-rate error on frontal, stationary faces yet degrades sharply under head pose: on MMPD, the state-of-the-art FactorizePhys backbone's MAE grows $1.60\times$ from frontal ($|\text{yaw}|{<}15^\circ$) to large-yaw ($|\text{yaw}|{\geq}45^\circ$) frames. We argue that pose is a \emph{coordinate-structural} nuisance rather than a data-augmentation problem: in image coordinates the same pixel maps to different anatomy at different poses, blocking three priors otherwise natural for rPPG, namely the dichromatic reflection model, pulse-phase invariance across skin regions, and the POS/CHROM chromaticity projection, each of which presumes a stable anatomy-to-pixel mapping. We introduce \textbf{CanonicalPhys}, which prepends a differentiable four-point homography that fixes four facial anchors at canonical positions; in this canonical frame the three priors become expressible as a per-pixel Lambertian weight, a cross-ROI temporal consistency loss, and knowledge distillation from windowed POS, none of which adds trainable parameters over the backbone. At an identical parameter count, CanonicalPhys reduces MMPD's frontal-to-large-yaw MAE degradation from $1.60\times$ to $1.33\times$ and flattens the mild-yaw bin from $1.32\times$ to $1.07\times$ (across CanonicalPhys variants), with matched cross-dataset MAE reductions of up to $32\%$ on pose-rich targets. Code: https://github.com/infraface/CanonicalPhys

Cardiovascular diseases are the leading cause of death worldwide, and conditions such as arrhythmia often require long-term monitoring for effective detection and diagnosis. However, current wearable monitoring devices are bulky, uncomfortable, and typically rely on clinicians to manually evaluate electrocardiograms (ECGs). While Deep Learning (DL) algorithms have shown superior performance in arrhythmia detection and classification, their computational complexity coupled with high power consumption limit deployment in wearable devices. To address this challenge, this paper investigates the use of approximation techniques to reduce the power and energy consumption of DL architectures while maintaining acceptable classification performance. Specifically, techniques such as data precision reduction and approximate multiplication are investigated in a state-of-the-art DL model and its corresponding hardware architecture. The model is trained and validated using the MIT-BIH Arrhythmia Database, and hardware implementations employing various approximate multipliers are synthesized and evaluated. Compared with the state-of-the-art 8.75 μW (and 2.08 μJ) reference architecture, our proposed architecture consumes 3.07 μW (and 2.17 μJ) at 12 kHz, showing 64.9% reduction in power consumption while providing an acceptable output quality, i.e., 93.7% classification accuracy and 92.1% sensitivity. At 100 MHz, our proposed architecture consumes 9.45 mW (and 0.8 μJ), showing 61.5% reduction in energy consumption as compared to the state-of-the-art architecture. These results demonstrate that our proposed approximations significantly extend wearable device battery life while preserving the required arrhythmia classification performance.

Deploying humanoid robots in unstructured terrain remains an open problem. While classic reinforcement learning struggles with the sheer complexity of real-world interactions, more promising methods leveraging human priors remain limited to models lacking contextual awareness. The restricted motion synthesis is a direct consequence of existing dataset pipelines failing to capture human-scene sequences in challenging environments. To bridge this gap between humanoid learning and scene reconstruction, we introduce the Egocentric Human-Terrain Reconstruction (EgoHTR) dataset. We develop and open-source a reconstruction pipeline capturing 55 scene-aligned 4D human motion sequences in diverse, complex environments using a multi-sensor setup of egocentric wearables and a portable 3D scanner. The resulting dataset comprises over 150k frames, which we evaluate against motion-capture ground truth, demonstrating state-of-the-art accuracy and establishing a rigorous benchmark for human motion analysis and synthesis. Further, we leverage this data to train perceptive locomotion policies, demonstrating hardware deployment on a Unitree G1 for reconstructed reference motions. Our pipeline enables community-driven dataset extensions and factors the problem to help researchers build foundational, context-aware robots that reliably traverse uneven terrain.

Low-power event-based Analog Front-Ends (AFEs) are essential for building efficient, end-to-end neuromorphic signal processing systems. In this paper, we present an event-based AFE Application-Specific Integrated Circuit (ASIC) optimized for biomedical signal acquisition and encoding. The chip features 32 independently programmable input channels with dual-mode encoding mechanism outputs, comprising Pulse Frequency Modulation (PFM) and adaptive Asynchronous Delta Modulator (aADM) circuits. The aADM encoder provides an auto-scaling mechanism that adapts the encoding data-rate based on the input signal envelope in real-time, enabling very high data compression for low-power information transmission. This approach paves the way toward adaptive wireless communication of neural signals for on-line processing in brain-computer interfaces. Fabricated in a 180 nm CMOS process, the proposed ASIC offers a highly configurable interface compatible with state-of-the-art Spiking Neural Network (SNN) neuromorphic processors.

Detecting muscle fatigue via surface electromyography (sEMG) is essential for applications in sports, rehabilitation, and wearable health monitoring. Accurate and timely detection of fatigue is crucial for preventing injuries, optimizing physical performance, and ensuring user safety during prolonged activity. However, existing deep learning models are often unsuitable for this task due to their high computational cost and dependence on large-scale data. In this work, we propose an energy-efficient framework for muscle fatigue detection based on Spiking Neural Networks (SNNs), which exploit sparse, event-driven computation and temporal modeling. We further introduce a quantization-compatible training scheme (SDH) that combines multiple regularization terms to improve robustness under noisy conditions. Evaluated on two public sEMG datasets against a broad set of baselines and under seven noise conditions including physically motivated perturbations, our quantized SNNs match or exceed strong baselines while remaining more stable under diverse noise and reducing estimated energy consumption by up to 201.77x. These results demonstrate the framework's strong potential for real-time deployment in low-power wearable systems.

Deploying deep learning models for automated electrocardiogram classification on resource-constrained wearable devices remains challenging due to high computational costs. To address this, we propose LSTrans, a lightweight hybrid model designed for efficient and sensitive ECG analysis. LSTrans introduces a specialized 1D convolutional backbone with an interleaved layer architecture to capture both macroscopic rhythmic trends and microscopic morphological variations. This backbone is cascaded with a Transformer encoder to model long-range temporal dependencies, incorporating Low-Rank Adaptation across critical layers to compress the model and reduce the trainable parameter space. We further employ homogeneous and heterogeneous knowledge distillation to transfer diagnostic expertise from high-capacity teacher models to the student. Experimental results on multiple benchmark datasets demonstrate that LSTrans achieves a competitive balance between diagnostic sensitivity and resource efficiency, substantially reducing peak memory footprints and training latency during downstream adaptation. The source code is available for review at https://github.com/zyee00128/LSTrans4BIBM.

Continuous oxygen saturation (SpO$_2$) estimation from wearable photoplethysmography (PPG) is important for long-term health monitoring, but low-quality red and infrared PPG segments can distort waveform morphology and degrade SpO$_2$ prediction accuracy. Existing PPG denoising and reconstruction methods usually optimize waveform fidelity or heart rate characteristics, while time-domain waveform loss on PPG signals alone insufficiently preserves frequency structure and SpO$_2$-relevant information. This paper proposes a SpO$_2$ predictor-guided stage-wise time-frequency reconstruction framework for low-quality dual-wavelength PPG signals. The proposed method first selects high-quality PPG segments to pretrain a SpO$_2$ predictor. A masked reconstruction model is then trained to recover randomly masked PPG regions using a joint reconstruction objective that combines time-domain waveform loss with frequency-domain loss computed from the short-time Fourier transform (STFT). To make the reconstruction task physiologically relevant, the pretrained SpO$_2$ predictor is incorporated as an additional constraint, encouraging the reconstructed PPG to preserve SpO$_2$ information rather than only minimizing waveform reconstruction error. The SpO$_2$ predictor and PPG reconstructor model are optimized through four training stages. Experiments on the public OpenOximetry Repository and a private wearable PPG dataset show that the proposed approach achieves the lowest subject-level MAE, with 2.882% on the public dataset and 2.359% on the private dataset.

The modern-day surge in popularity of wearable devices poses a fundamentally unique motion capture problem: reconstructing full-body movement from any set of sensing hardware worn at a given moment. Yet, most research efforts assume fixed sensor configurations (e.g. IMU suits or HMD-centric rigs) and cannot generalize across them. In contrast, we argue that motion capture should prioritize unobtrusive and lightweight devices such as smartphones, smartwatches, smart glasses, and smart insoles, and study the interplay between them. To this end, we make three contributions. First, we present a large-scale multi-modal dataset synchronizing these consumer-grade sensors with ground-truth 3D motion, spanning 50 diverse activities including everyday tasks, sports, and social interactions. Second, we propose WHIP, a baseline generative model that reconstructs motion from arbitrary subsets of available sensors, robustly handling missing modalities and producing physically plausible motions. Third, we conduct a systematic study of sensor complementarity, quantifying how different modalities complement one another. Code and dataset are available at https://vcai.mpi-inf.mpg.de/projects/WHIP/

Open physiological corpora are heterogeneous: they use different sensors, labels, sampling rates, recording settings, and clinical endpoints. They can support detector design, but they do not directly specify which detector rules should be built for a new contactless monitoring platform. We report a controlled four-analyst large-language-model (LLM) workflow for converting 68 public physiological corpora, screened for commercial-use compatibility, into an auditable library of candidate rule shapes for prospective validation. Four independent commercial LLM families read the corpus documentation under a controlled prompt and produced 695 candidate rule markers (top-markers). Deduplication retained 649 rule records; a threshold-bounds audit then flagged 51 sanity violations for clamping or curator review. Cross-corpus consolidation produced 436 unique rule shapes. Gate-tagging against two hard invariants, native target-hardware channel availability and no multi-night per-patient personalization, identified 94 build-now detector components across four detector-family buckets. The pipeline does not produce a validated clinical detector. It produces an auditable engineering cascade in which analyst disagreement, threshold checks, curator review, and automated continuous-integration (CI) checks route literature-derived rules toward prospective hardware validation.

Wearable motion sensing provides a continuous and scalable window into human behavior and health, making it a natural fit for foundation models, yet its pretraining and scaling principles remain poorly understood. Prior work studies isolated design choices, such as sensor placement or sampling frequency, often under fixed settings and narrow downstream tasks that fail to capture real-world sensing diversity. We introduce Inertia-1, a fully open exploration of wearable motion foundation models. Using massive corpora of accelerometer data from global sources spanning more than 18.2M hours, we build a controlled framework for studying the full lifecycle of wearable motion foundation models, covering data choices such as sensor modality, device placement, sampling rate, window length; model choices such as architectures and model size; and training choices such as pretraining objective and data scale. Extensive evaluations across 15 datasets spanning human activity recognition, freezing-of-gait detection, and disease prediction reveal intriguing findings for building motion foundation models that generalize across tasks and sensing conditions. Collectively, Inertia-1 not only presents state-of-the-art recipes for diverse downstream tasks, but also serves as a comprehensive, practical, and open cookbook for wearable motion representation learning.

Heart rate measurement is one of the key requirements for real-time health monitoring, in particular for health caring of elderly people. Traditional heart rate measurement relies on contact sensing mechanisms such as some heart rate measurement devices at medical hospitals or some wearable devices with embedded sensors such as Apple Watch, etc. In this paper, we develop a system for non-contact, real-time, heart rate measurement using image processing with commodity cameras such as an embedded camera on a laptop, where we use an innovative algorithm to capture the relevant signals for the computation of heart rate in a time series in real life environments. The presented heart rate computation (HRC) process is composed with four major steps: (a) identify frames per second of the camera in use, i.e., 30 frames per second for a given camera, (b) face detection (FD) with shape predictor of 68 face landmarks using deep learning (DL) method, (c) time sliding window (TSW) algorithm to de-noise the signal by smoothing out the noise, and (d) compute heart rate based on identified signal periodicity. We test and analyze the developed prototypes against heart rate results by Apple Watch and check the difference range in multiple rounds and compute the mean of the difference for the measurement values of the heart rate of the same person at the same time. We will do further tuning and optimization of the present methods and deploy the system as a personal AI agent [6] for health monitoring as our future directions.

Generalizing sleep staging models to unseen datasets is challenging, and typical domain generalization (DG) methods often rely on multiple source domains or domain labels that are rarely available in practice. We tackle the stricter and more practical setting of single-source domain generalization: training on a single labeled source dataset, without domain labels or access to target data. We present SleepBand, a physiology-guided framework that embeds oscillatory priors via a learnable Morlet filter bank and a structured integration-and-recalibration pipeline. This anchors representations to domain-invariant sleep rhythms (e.g., slow waves, spindles), reducing reliance on dataset-specific artefacts. On five public datasets, SleepBand achieves state-of-the-art SDG performance and remains competitive under leave-one-domain-out (multi-source) DG. Analyses show that the learned filters align with canonical neurophysiology and that robustness stems from focusing on narrowband, physiologically meaningful cues. Our results suggest that principled, physiology-aware inductive biases are a promising path for robust single-domain sleep staging. Code is available at https://github.com/lzcn/sleep-band

Decoding hand kinematics from surface electromyography (EMG) is a core challenge in wearable biosignal processing with clinical relevance for prosthetic control and motor rehabilitation. Most representation learning approaches for EMG focus on discrete gesture classification, and few focus on continuous regression. We present KinEMbed, a cross-modal contrastive learning framework for hand kinematics regression that jointly trains dual encoders -- one for windowed EMG features and one for kinematic (joint angle) targets. The resulting embeddings inherit the geometric structure of the kinematic space without requiring kinematic signals at inference time. Evaluating on the NinaPro DB8 dataset that includes both able-bodied users and subjects with limb difference (N=11), KinEMbed outperforms PCA, PLS, autoencoder and contrastive (CEBRA) baselines on held-out sessions, with largest gains on the most challenging thumb degrees of articulation. We position this work as a first step toward contrastive representation learning for regression of hand kinematics from structured wearable biosignals.

As haptic interfaces integrate more seamlessly into wearables and everyday environments, they increasingly require actuators that are soft, thin, silent, and energy efficient. However, conventional motors and temperature-responsive polymers often struggle to deliver these properties due to their bulky form factors and high power consumption. High-Voltage Electrostatic Actuators (HVEAs), which generate force by applying an electric field to localized charge concentrations using high voltages and ultra-low currents, have recently emerged as a compelling alternative due to their fast, silent, and low-power operation within highly customizable and compliant form factors. This paper presents a focused review of HVEAs for haptics, examining four major classes: electrostatic switchable adhesives, dielectric elastomer actuators, soft electrohydraulic actuators, and electrokinetic pumps. For each class, we describe their mechanisms that enable haptic output; characterize their bandwidths, force densities, and spatial scalability; and evaluate their versatility for rendering cutaneous and kinesthetic feedback across wearable and world-grounded interfaces. Through this cross-technology analysis, we identify common design constraints and emerging strategies for improving ergonomics, streamlining fabrication, and integrating self-sensing. We conclude by outlining where HVEAs are uniquely positioned to advance haptic interaction and highlighting key research directions needed to translate these technologies into practical systems.

Sleep physiology arises from the coordinated dynamics of the central nervous system (CNS) and autonomic nervous system (ANS), as reflected by multimodal polysomnography signals including EEG, EOG, EMG, ECG, and respiration. However, existing sleep foundation models often fuse heterogeneous biosignals in a topology-agnostic manner, overlooking their physiological organization. We introduce Omni-Sleep, a sleep foundation model that uses the CNS/ANS partition as a physiological prior for topology-constrained representation learning. Omni-Sleep learns structured representations through three objectives: intra-system consistency, which captures shared subsystem-level factors within neural and cardio-respiratory signals; inter-system synchronization, which aligns subsystem trajectories to model brain--body dynamics; and latent-space masked temporal modeling, which captures long-horizon sleep dynamics. Pre-trained on over 100,000 hours of multi-center multimodal PSG data, Omni-Sleep is evaluated on sleep staging and multi-disease classification. Across datasets and modality-ablation settings, Omni-Sleep outperforms strong foundation-model baselines, showing improved label efficiency, cross-dataset generalization, and robustness to missing modalities. These results highlight the value of physiological hierarchy for generalizable sleep representation learning. Code is available at https://github.com/AutoBrain-sleep/OmniSleep.

Foundation models have recently emerged as a powerful paradigm for learning transferable representations from large scale biomedical data, yet existing approaches for physiological waveforms primarily optimize reconstruction or forecasting objectives that do not explicitly preserve clinically meaningful waveform morphology. Electrocardiograms (ECGs) and pulse oximetry (SpO2) waveforms encode rich cardiovascular and hemodynamic information through their morphological structure. In this work, we introduce MorphologyFM, a multimodal foundation model pretrained on paired ECG and SpO2 waveforms from the MIMIC critical care database using a morphology aware self supervised learning objective. MorphologyFM combines morphology guided masking, cross modal representation learning, and contrastive latent alignment to learn representations that capture clinically relevant physiological structure without requiring manual annotations. We evaluate MorphologyFM across multiple downstream prediction tasks, including arrhythmia classification, hypoxemia prediction, mortality prediction, and length of stay estimation, demonstrating consistent improvements over representative self supervised learning methods, including Masked Autoencoders (MAE), contrastive learning, Barlow Twins, and Joint Embedding Predictive Architectures (JEPA). Furthermore, we show that jointly modeling ECG and SpO2 waveforms produces more transferable representations than single modality pretraining. Our results establish waveform morphology as a powerful inductive bias for self supervised physiological representation learning and introduce MorphologyFM as a general purpose foundation model for continuous physiological monitoring.

WiFi-based human pose estimation (HPE) enables the detection and interpretation of human body positions and movements without the need for wearable devices while preserving individual privacy concerns. Implementing this solution requires enhancing model performance and maintaining efficiency, especially on resource-constrained devices. This paper introduces a novel framework, WiLHPE, for lightweight and efficient human pose estimation using WiFi CSI signals. Empowered by a camera-based model during training, WiLHPE processes raw WiFi signals directly to estimate human poses in the testing phase. It employs a novel neural network architecture to dynamically learn convolutional kernels and apply attention mechanisms across channel and frequency spaces. This innovative method diversifies the kernels to improve the recognition capabilities of WiFi signals without adding complexity, ensuring efficiency. Additionally, the Tree-Structured Parzen Estimator algorithm is employed to optimize the critical hyperparameters of the neural network efficiently, minimizing the time required for optimal hyperparameter search compared to heuristic methods. Results from experiments on both the MM-Fi and WiPose datasets highlight the superiority of WiLHPE over state-of-the-art approaches, achieving 85.96% and 94.27% at PCK50, respectively, with minimal computational overhead. Notably, WiLHPE performs impressively even under challenging conditions, maintaining around 80% at PCK50 under AWGN noise with an error variance of 0.5.

Clinical time series prediction in intensive care units remains challenging due to heterogeneous physiological variables and informative missingness. The presence or absence of a measurement can reflect clinical decisions and patient severity, and thus missingness can serve as a predictive signal rather than a simple data artifact. This work presents CISM, a Channel-Independent Spectrogram framework with a Missingness stream for clinical multivariate time series prediction. CISM converts each clinical variable into a variable-wise time-frequency spectrogram, preserves variable identity through variable-aligned encoding, and aligns an explicit missingness stream with the spectrogram representation. Experiments on an in-hospital mortality task derived from MIMIC-IV show that CISM achieves the highest mean AUROC (0.7225), AUPRC (0.3308), and F1 (0.3808) among the compared time series, missingness-aware, vision, and time-frequency baselines. Ablation studies further show that observation patterns provide a meaningful informative signal. Pixel-level mask injection improves performance over plain spectrogram inputs and recovers much of this predictive value. The aligned missingness stream contributes a further, complementary gain in both AUROC and AUPRC. These results highlight the importance of modeling observation patterns as structured signals in clinical time series prediction.

Quantitative 3D spatial reasoning from egocentric RGB-D video is a critical capability for next-generation wearable assistants. Yet existing benchmarks do not reflect the challenges of handling (1) natural egocentric video, (2) posed RGB-D video inputs, and (3) challenging quantitative 3D spatial reasoning Q&A. To fill this gap, we introduce R3D-Bench (Reasoning in 3D), a benchmark of 3,033 quantitative spatial reasoning questions across 15 types -- spanning multiple-choice, distance-based, and volumetric reasoning questions -- built on top of 57 egocentric video sequences from Aria Digital Twin. To set a strong baseline on this dataset, we introduce R3D, a model-agnostic spatial tool-calling framework. In contrast to existing approaches that directly embed 3D information into the model's input representation, R3D constructs a 3D scene from video using segmentation and depth-lifted object representations. It provides this information to an LLM through eight composable spatial tools. On R3D-Bench, R3D with Qwen3-VL 235B achieves 73.5% mean relative accuracy, substantially outperforming the best depth-enabled baseline (CuTR+Tools, 61.9%) and the best RGB-only baseline (Gemini 3 Flash, 46.5%).

As wearable devices enable continuous first-person recording, AI assistants must reason across long time horizons to recall past experiences-a capability known as episodic memory. Current benchmarks often rely on offline evaluation with access to entire video files, failing to simulate the streaming reality of wearable intelligence. We introduce S-EMBER (Streaming Egocentric Memory Benchmark for Episodic Retrieval), a large-scale benchmark comprising 3,141 videos totaling 388 hours of organic activity captured via Ray-Ban Meta smart glasses. S-EMBER formalizes grounded streaming episodic retrieval, a paradigm shift from global offline search to causal, active recall triggered by visual events in a continuous stream. We provide 9,448 QA pairs requiring manual visual proof through precise temporal localization and supporting flexible response lengths to simulate natural human-AI interaction. Our extensive benchmarking of frontier models uncovers a localization paradox: while semantic reasoning improves with parameter scale, temporal grounding precision remains a stagnant architectural bottleneck that does not benefit from brute-force increases in model size, resolution, or frame density. S-EMBER establishes a hardware-authentic foundation for developing grounded, reliable episodic memory in the next generation of wearable AI agents.

Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost. We show that this blind spot misranks models: across 11 architectures, models with comparable pointwise error diverge by up to 53° in phase accuracy, equivalent to roughly 123 ms for a 1.2 Hz cardiac rhythm and invisible to standard metrics. To enable development of models that escape such failures, we introduce TimeSynth, a controlled benchmarking framework with two reusable components: a physiologically grounded generator producing signals with analytically known ground-truth dynamics from parametric models fitted to real electroencephalography, electrocardiography and photoplethysmogram signals, along with diagnostics quantifying amplitude, frequency, phase, and state-transition fidelity. Linear and full-sequence attention models systematically lose frequency and phase information despite acceptable amplitude error, whereas architectures with localized temporal structure better preserve dynamical fidelity and adapt to observable state transitions; none, however, reliably preserves stochastic switching. Because the dominant determinant of fidelity is architectural, model choice becomes a principled, use-case-driven decision rather than a search for a single winner. TimeSynth thus supplies the controlled preclinical stress test missing before models are coupled to patient data, with a reusable generator and diagnostics for fidelity-aware development.

Remote photoplethysmography (rPPG) estimates physiological signals from facial videos by analyzing subtle pulse induced skin color variations. Despite recent progress, existing self-supervised rPPG methods mainly reconstruct masked pixels or low-level visual representations, which can bias the model toward facial appearance rather than latent physiological dy namics. Moreover, most recent Mamba-based approaches scan facial video tokens only in chronological order, limiting their ability to exploit the cyclic structure of pulse signals. To ad dress these limitations, we propose RhythmJEPA, a rhythm structured joint-embedding predictive learning framework for rPPG. Instead of reconstructing RGB frames, RhythmJEPA predicts latent teacher representations from masked facial videos, thereby encouraging physiology-aware representation learning in the embedding space. To explicitly model pulse-related tem poral structure, we introduce a Cyclic Rhythm-State Plan ner (CRSP), which estimates frame-wise latent physiological states and decodes the most plausible cyclic state path via dynamic programming with a constrained transition grammar. Guided by the decoded states, we further design a Dual Order Mamba Encoder (DOM), which combines conventional chronological scanning with state-ordered scanning to capture both local temporal continuity and long-range rhythm-consistent dependencies. Finally, a lightweight Spatial Pulse Mixer (SPM) extracts compact pulse-sensitive facial tokens with a favorable balance between complexity and performance. Experiments on PURE, UBFC-rPPG, and MMPD show competitive performance over representative rPPG methods. The codes are available at https://github.com/deconasser/RhythmJEPA.

In this document, we describe characteristics and technical details of the multimodal biosignal dataset DOSE-I of procedural sedation for endoscopy published on zenodo. The DOSE-I dataset includes 78.5 hours of recording in 171 records ranging from 6.7 to 70.8 minutes (mean: 27.5, SD: 11.6) of 281 endoscopic procedures. 1129 (median: 6 per record) transitions of consciousness and 7328 (median: 39 per record) individual sedation depth labels were recorded. In addition to clinically annotated biosignals, the DOSE-I dataset provides detailed static data about the respective study subject and metadata about the respective recordings. To further support future research, we provide details about artifact detection and preprocessed pEEG features, too. C code used for this preprocessing is provided separately via Github.

Wrist-worn photoplethysmography (PPG) enables continuous monitoring of cardiopulmonary physiology, but reliable heart rate (HR) and respiratory rate (RR) estimation in free-living conditions remains challenging due to non-stationary motion artifacts that spectrally overlap with physiological dynamics. Existing signal-processing methods degrade under strong motion, while unconstrained deep learning approaches often lack physiological interpretability and identifiable structure. We propose a Physically-Constrained Harmonic Separation (PCHS) framework that formulates HR and RR estimation from wrist PPG as an analysis-by-synthesis problem, where accelerometer measurements condition artifact separation rather than directly regressing vital signs. A physics-guided harmonic generator decomposes the observed signal into quasi-periodic physiological components and a motion-related residual, enabling HR recovery from the fundamental frequency and RR prediction from respiratory-driven modulations of the harmonic parameters. Robust reconstruction objectives, separation constraints, and uncertainty-aware weighting stabilize the decomposition under motion. Experiments on the motion-intensive PPG-DaLiA dataset demonstrate that PCHS outperforms state-of-the-art methods while yielding interpretable signal decompositions that effectively disentangle physiological activity from motion artifacts.

Wearable devices produce large, high dimensional training logs for everyday runners, and interpretation rather than data collection is now the limiting step. This paper evaluates five dimensionality reduction models, three autoencoder variants, PCA, and a Variational Autoencoder, on their ability to compress nine sensor runner profiles into a single scalar performance indicator, the latent score. Because the setting is fully unsupervised, model quality is assessed along two complementary axes: reconstruction error (Mean Squared Error) and latent score interpretability, measured via Spearman and Kendall rank correlations, Mutual Information, and Permutation Importance. These are combined into a composite selection criterion that prevents selecting models on reconstruction accuracy alone. Feature rankings from the four metrics are aggregated via a modified Borda count, and their stability is confirmed by bootstrap validation. A two feature linear baseline is included to anchor the comparison. Deep autoencoder achieved the lowest reconstruction error and the highest composite score. Once the PCA hidden layers were widened, the deeper variants became closely competitive with Deep AE on the composite criterion, indicating that the limiting factor was hidden layer capacity rather than the one dimensional bottleneck. Running pace, aerobic decoupling, and average heart rate emerged as the dominant latent score drivers across all models and resampling runs, consistent with established physiology.

Video-based remote physiological measurement (RPM) is highly accessible but remains fragile under varying illumination, skin tones, and motion. Radio frequency (RF) radar is largely invariant to illumination and appearance, providing complementary cardio-respiratory micro-motion cues; however, requiring radar at inference is often impractical due to its limited ubiquity and deployment overhead. We propose RPM-Distill, a physiology-guided cross-modal distillation framework that leverages synchronized radar only during training while retaining video-only inference. Our key observation is that although RGB and RF waveforms differ in sensing physics and time-domain morphology, they share similar latent periodic rhythm in the frequency domain. We thus distill physiology-structured spectral evidence to improve robustness, via losses that (i) anchor the fundamental peak, (ii) match the off-peak background distribution, and (iii) preserve spectral morphology and sharpness. To avoid negative transfer under sample-level teacher quality and alignment uncertainty, a spectral policy network predicts sample-level distillation gates and component weights from the student--teacher spectral relation map, learned with a meta bilevel objective on a small labeled validation split. Through extensive experiments in challenging conditions and cross-dataset settings, RPM-Distill brings 81% MAE and 21% correlation improvement over unimodal baselines. Code is at https://github.com/WJULYW/RPM-Distill.

Wearable devices and Internet of Things (IoT) sensors require on-sensor processing of biosignals and environmental data, including computationally demanding operations such as nonlinear activation functions for neural network inference, sensor calibration curves to map raw readings to physical units, and signal preprocessing functions like logarithmic compression and power operations for feature extraction. These functions exhibit significant complexity, often involving transcendental operations and multivariate dependencies that are costly to implement digitally. Analog function approximation provides a power-efficient alternative by performing these computations in the analog domain, thereby reducing the energy overhead associated with analog-to-digital conversion and subsequent digital processing. Flexible Electronics (FE) present a particularly attractive platform for wearable applications due to mechanical flexibility and low-cost fabrication, but impose strict constraints on circuit density and power consumption, making efficient analog implementations critical but challenging. This work introduces Analog Kolmogorov-Arnold Networks (AKANs), developed via hardware-software co-optimization, to approximate these complex multivariate functions accurately under hardware imperfections. Our method incorporates circuit-level error modeling during training and applies pruning at both software and hardware levels to reduce area and power. Validation across multiple benchmarks demonstrates that our proposed pruning methodology not only reduces hardware cost but can also improve approximation accuracy by regularizing spline parameters. Results show up to 55% area and 50% power savings, with average reductions of nearly 30% across datasets, highlighting AKANs as a robust and generalizable framework for low-power analog function approximation in FE.

Recent advances in Human Activity Recognition (HAR) from wearable sensors have shown that multi-modal deep learning models consistently outperform their uni-modal counterparts. Modalities can include IMUs, RGB cameras, audio signals, and others. One important aspect of multi-modal deep learning is the sensor fusion approach we apply. Over recent years, multiple fusion paradigms have been proposed for multi-modal HAR. However, to the best of our knowledge, no head-to-head comparison of these paradigms exists on a common multi-modal HAR benchmark dataset. To address this research gap, we systematically compare seven state-of-the-art sensor fusion methods on the recently released HARMES dataset, which comprises 61 hours of fully labeled IMU, audio, and ambient humidity data. The chosen dataset focuses on 15 household and personal hygiene activities of daily living (ADLs). By applying the seven different fusion techniques to a state-of-the-art multi-modal model architecture, we show that Gated Multi-modal Fusion achieves the highest macro F1-score (0.82), surpassing the concatenation-based late fusion HARMES paper baseline of 0.76 by +6pp under leave-one-participant-out evaluation. All code used in our experiments is made publicly available on GitHub.

Heart Rate Variability (HRV) analysis is a key indicator of cardiac physiological state and aids in disease diagnosis. However, research on HRV parameters in healthy individuals remains limited, and no gold standard exists. This study evaluates HRV indices in 40 healthy adults (20 men, 20 women, aged 30-50) to improve HRV's clinical utility. Using computational methods for signal processing and data analysis, time, frequency, and nonlinear indices were analyzed to address five questions: (1) normality, (2) stability, (3) correlation, (4) reproducibility, and (5) consistency. Key findings: (1) Time-domain and nonlinear indices, particularly global and LF (low frequency), follow normal distributions, with gender differences noted. (2) Most indices are stable except HF (high frequency)-related ones. (3) High correlations in HF-related indices suggest redundancy, indicating only one is necessary in studies. (4) Comparisons with the Fantasia database revealed less than 10% error for most indices, except SD2 and SDNN in women (greater than 15%). (5) Time-domain and nonlinear indices show low inter-study variability, while frequency-domain indices exhibit high variability, limiting cross-study comparisons. The selected indices-ApEn and IRRR (global variability), HRVi and SD2 (LF), and MADRR or rMSSD (HF)-are best suited for accurately representing HRV components and enhancing its clinical and research relevance.

Respiratory acoustic foundation models (FMs) are benchmarked exclusively on smartphone recordings, yet clinical deployment increasingly targets body-coupled (BC) wearables whose sensors attenuate high-frequency content through tissue and bone, leaving FM reliability uncharacterised. We introduce BCoughBench, evaluating five FMs (OPERA-CT/CE/GT, HeAR, M2D+Resp) on nine classification tasks (AUROC, sensitivity at 95% specificity, Expected Calibration Error) and three age regression tasks (MAE vs. a mean-predictor baseline) across five EBEN-simulated BC sensor conditions on five labeled cough datasets. Mean AUROC declines from 0.785 (smartphone) to 0.689-0.723, degrading most under temple vibration pickup ($Δ$ = -0.096) and least under the soft in-ear ($Δ$ = -0.062). No FM meets the clinical sensitivity threshold (Se@Sp95 $\geq$ 0.20) on most disease tasks under any BC sensor. Sex classification on the CIDRZ cohort collapses (AUROC 0.954 to 0.596-0.628, $Δ$ = -0.341) while COVID detection is nearly unaffected ($Δ$ = -0.004). Age regression is robust, improving under the forehead accelerometer on CoughVID (MAE 9.61 to 8.97 yr); HeAR leads on regression and demographic tasks, M2D+Resp on disease and characteristic tasks. BCoughBench provides a reproducible framework for FM evaluation under wearable conditions.

Remote Photoplethysmography (rPPG) enables contactless pulse estimation from facial videos, serving as a vital tool for health monitoring. However, current deep learning methods often struggle under complex disturbances, particularly varying illumination, facial expressions, and unconstrained head movements. In such scenarios, subtle physiological signals are easily dominated by external interference, making the recovered rPPG waveform unstable and unreliable. One important reason is that most existing methods directly model the rPPG signal in a unified manner, where different signal components are coupled during reconstruction. This makes it difficult to preserve weak pulse-related variations when strong disturbance-induced changes are present. To address this challenge, we propose PhysFlow, a frequency-decoupled dual-field rectified flow framework tailored for robust rPPG estimation. Specifically, the ground-truth rPPG signal is decomposed into trend and amplitude components, which are used as separate supervisory targets. Based on the extracted facial features, PhysFlow learns two component-specific conditional velocity fields to model the two components separately. This design reduces mutual interference between different components and improves the robustness of rPPG reconstruction under complex disturbances. Moreover, the rectified flow formulation enables efficient waveform reconstruction with only a few ordinary differential equation (ODE) integration steps. Extensive experiments on multiple benchmark datasets demonstrate that PhysFlow outperforms state-of-the-art methods in both heart-rate estimation and rPPG waveform reconstruction across diverse challenging scenarios.

Apnoea of prematurity is characterised by recurrent episodes of cessation of breathing and remains difficult to detect reliably using routinely monitored physiological signals in the Neonatal Intensive Care Unit (NICU). Existing bedside monitors rely primarily on respiratory rate and oxygen saturation thresholds, often generating high false-positive alarm rates and missing short or irregular events. Improving automated detection using routinely acquired clinical signals could enhance identification of clinically meaningful events without additional sensing hardware. We evaluated deep learning-based detection of apnoea-related Cessation Of BrEathing (COBE) events using impedance pneumography (IP), electrocardiography (ECG), and photoplethysmography (PPG) signals from approximately 430 hours of NICU recordings collected from 24 pre-term infants. Three independent reviewers annotated COBE events, producing a dataset of 346 COBE and 608 non-COBE events. We compared a shallow convolutional neural network (CNN), residual networks (ResNets), and a ConvNeXt architecture using an independent held-out test set. Across all architectures, detection performance was influenced more strongly by signal modality than by architectural complexity. Unimodal IP-based models achieved balanced accuracies of 86.8-88.0%, outperforming ECG-derived (62.6-69.7%) and PPG-derived (65.1-66.4%) respiratory surrogates. Multimodal fusion yielded modest improvements over IP alone. The best-performing model, a ConvNeXt architecture combining IP and PPG inputs, achieved 88.7% balanced accuracy and an F1 score of 0.75 on the independent test set. These findings demonstrate that deep learning models applied to routinely monitored NICU signals can reliably detect COBE events and highlight the importance of signal modality in data-constrained neonatal monitoring settings.

Remote photoplethysmography (rPPG) estimates the blood volume pulse (BVP) signal from facial videos, enabling contact-free health monitoring. Conventional clip-wise approaches, which use video clips as input, require capturing over one hundred frames before inference, thus introducing several seconds of delay and hindering real-time use. Meanwhile, frame-wise approaches struggle to capture long-range temporal and periodic features of physiological rhythms, and therefore lead to reduced estimation accuracy. To overcome these issues, we propose StreamPPG, a unified architecture that enables low-latency frame-wise physiological signal estimation while achieving competitive accuracy compared with clip-wise approaches. StreamPPG is trained under a consistent privileged learning (CPL) strategy, which leverages ground-truth rPPG signals as privileged information to enhance the model's representation capability. Extensive experiments demonstrate that StreamPPG achieves state-of-the-art accuracy across multiple datasets while maintaining real-time throughput on edge devices.

Multimodal large language models (LLMs) are increasingly adopted to interpret 12-lead ECG images, though the interpretations often lack validation. However, ECG image understanding significantly differs from general images as it depends on precise waveform morphology, lead relationships and accurate interval measurements. This study investigated whether zero-shot multimodal LLMs can reliably distinguish normal and abnormal ECG images and, in parallel, evaluated CNN-based models for clinically grounded references. Standard 12-lead ECG recordings were rendered as single-page images for a binary normal-abnormal classification task. Three prominent LLMs (GPT-5.2, GPT-4.1, and Gemini-2.5 Pro) were tested using a fixed zero-shot prompt across multiple runs. In parallel, a physiology-aware CNN-based model was developed with the capability to aggregate features from the predefined anatomical lead groups. The model was compared with ResNet18, DenseNet121, VGG16 baselines, and all the models were evaluated on an internal test set and external PTB-XL dataset. Across seeds, CNN-based models demonstrated stable discrimination, with average internal ROC-AUC of 0.92-0.94, and external ROC-AUC of 0.85-0.86. The proposed LeadGroupECG model significantly improved over its backbone internally without compromising external generalization. It remained competitive with other baselines, while consistently highlighting anatomical lead-group contributions. In contrast, zero-shot LLM discrimination remained near-chance (ROC-AUC around 0.5). The PR-AUC improved slightly when ECGs used a grid-based calibration background compared with the grid-free ECGs. Although multimodal LLMs can generate reasonable ECG narratives, their zero-shot diagnostic discrimination remains limited. Therefore, clinically framed, domain-specific architectures remain essential for AI-based ECG interpretation.

The cardiovascular system evolves along a bounded trajectory in physiological state space that converges to a compact geometric object: the cardiac attractor. A wearable photoplethysmograph (PPG) or electrocardiograph (ECG) observes a one-dimensional projection of this attractor; by Takens' embedding theorem, delay coordinates reconstruct its full geometry. Three decades of nonlinear cardiac dynamics have extracted Lyapunov exponents, recurrence statistics, and sample entropy from reconstructed attractors, yet no principled account exists of which attractor properties capture which cardiovascular quantities, or why, leaving feature selection as a search problem and negative results uninterpretable. We introduce Attractor Domain Theory (ADT), which proves that the reconstructed attractor's information partitions into three mutually non-redundant domains: the Geometry Domain G (delay embedding; native capability: artifact rejection), the Ergodic Domain S (asymptotic statistical invariants; native capability: stability estimation), and the Variational Domain V (finite-time Lyapunov exponent field; native capability: hemodynamic inference). We prove a Domain Sufficiency Theorem (the Parseval analog for attractor information) and establish that three domains are necessary and sufficient. Geometry Domain validation via the SCSI framework across 176,742 PPG segments from four datasets yields AUC = 0.757 [0.686-0.828] and NPV = 0.966 after correcting three systematic evaluation artifacts (+0.179 net inflation). Ablation confirms C_NL as the dominant Geometry Domain component (Delta AUC = -0.413) and intra-domain redundancy across five components.

Physiological signals such as EEG, ECG, and PPG are widely used in clinical monitoring. Recent self-supervised learning (SSL) methods offer an attractive way to leverage unlabeled recordings, yet they still fall short in practice. In particular, current SSL methods struggle across heterogeneous datasets, often distorting clinically meaningful structures or learning shortcuts from temporal and cross-channel redundancy. Consequently, existing SSL methods often deliver limited performance under linear probing, a lightweight adaptation setting that better matches real-world medical scenarios. Moreover, most Transformer-based SSL models encode a flattened spatiotemporal token sequence, incurring high computation and memory cost, and are typically developed within a single modality. To address these limitations, we present SPOTR (Spatio-temporal Pooling One-Token Reconstruction), a compress-reconstruct pretraining framework that introduces a single-token global bottleneck for physiological signals. SPOTR compresses each waveform into a single-token representation and reconstructs the signal conditioned only on this representation. Meanwhile, SPOTR introduces an efficient spatio-temporal compaction module to reduce computation and memory cost. Pretrained on 20 datasets spanning EEG, iEEG, ECG, and PPG, SPOTR consistently outperforms the strongest baseline under linear probing, improving average AUC by 18.49%, 21.71%, 17.86%, and 4.64%, respectively. Compared with a representative general-purpose time-series foundation model, SPOTR achieves around 78% lower latency and 52% lower peak GPU memory on average. The code can be found at https://github.com/5GYYYYY/SPOTR.

Respiratory rate is a vital indicator of pulmonary and cardiovascular health, yet conventional methods for estimating respiratory rate are often intrusive due to their contact-based nature. Remote photoplethysmography offers a promising non-contact alternative and has been widely used for heart rate estimation; however, its potential for respiratory rate estimation remains underexplored. Existing methods typically adapt green and chrominance-based projections originally designed for heart rate estimation, which only partially capture respiratory dynamics. Most prior work focuses on the Eulerian representation with fixed or empirically selected RGB projections. To address these gaps, we propose a skin-tone-aware dynamic RGB signal projection that captures respiratory information. To mitigate the sensitivity of the Lagrangian representation to non-respiratory motion, we introduce a denoising network for motion-based remote photoplethysmography signals. We further design a phase-independent contrastive loss that enables Eulerian and Lagrangian representations to collaboratively learn respiratory rate information. We also introduce RR-rPPG, a respiratory-rate facial video dataset with Indian demographic representation. We evaluate the method on RR-rPPG and the publicly available COHFACE dataset, where it consistently outperforms comparison methods and achieves up to a 42.1% reduction in mean absolute error across the evaluated settings. The proposed framework demonstrates the effectiveness of jointly leveraging skin-tone-aware Eulerian and denoised Lagrangian representations for contactless respiratory rate estimation from facial videos. In addition, RR-rPPG contributes a diverse benchmark resource for future research in remote respiratory monitoring. The code and dataset will be made publicly available upon paper acceptance.

Remote photoplethysmography (rPPG) is a camera-based technique for measuring physiological signals, particularly cardiac activity. From the remotely measured signals, heart rate can be estimated, which is crucial for health monitoring. In this study, we investigate a driver health monitoring system based on remote heart rate estimation. However, driving environments represent uncontrolled settings where videos are subject to varying illumination conditions and frequent head movements. We introduce MS-rPPG, a multi-spectral framework that combines RGB with near-infrared (NIR) face video to alleviate rPPG estimation under challenging driving conditions. To combine the complementary features from two spectral videos, we propose a cross-spectral linear modulation (CSLM) strategy based on frequency-domain analysis. Moreover, we introduce MS-Mamba, a novel state space model designed to effectively model long-range temporal dependencies while jointly capturing cross-channel interactions between multi-spectral features. We collected a real-world dataset called MS-Drive, which was recorded from 50 participants while driving the vehicle. The proposed method was evaluated on the MR-NIRP Car dataset and MS-Drive datasets. The experimental results indicate that MS-rPPG shows better robustness and heart rate estimation accuracy than previous methods, highlighting its promise for driver health monitoring. The codes are available at github.com/ziiho08/MS-rPPG.

Modeling long-sequence medical time series data, such as electrocardiograms (ECG), poses significant challenges due to high sampling rates, multichannel signal complexity, inherent noise, and limited labeled data. While recent self-supervised learning (SSL) methods, based on various encoder architectures such as convolutional neural networks, have been proposed to learn representations from unlabeled data, they often fall short in capturing long-range dependencies and noise-invariant features. Structured state space models (S4) excel at long-sequence modeling, but existing S4 architectures fail to capture the unique characteristics of multichannel physiological waveforms. In this work, we propose SL-S4Wave, a self-supervised learning framework that combines contrastive learning with a tailored encoder built on structured state space models. The encoder incorporates multi-layer global convolution using multiscale subkernels, enabling the capture of both fine-grained local patterns and long-range temporal dependencies in noisy, high-resolution multichannel waveforms. Extensive experiments on real-world datasets demonstrate that SL-S4Wave (1) consistently outperforms state-of-the-art supervised and self-supervised baselines in a challenging arrhythmia detection task, (2) achieves high performance with significantly fewer labeled examples, showcasing strong label efficiency, and (3) maintains robust performance on long waveform segments, highlighting its capacity to model complex temporal dynamics in long sequences that most existing approaches fail to efficiently model, and (4) transfers effectively to unseen arrhythmia types, underscoring its robust cross-domain generalization. We additionally evaluate SL-S4Wave on multiple EEG tasks, achieving superior performance over strong baselines, demonstrating generalizability of our approach beyond cardiac waveforms.

Objective sleep assessment relies on polysomnography (PSG), yet clinical impact is often better reflected in patient-reported outcomes (PROs) such as sleepiness and fatigue. Existing summary indices, including the Apnea-Hypopnea Index (AHI), provide limited insight into the multidomain physiology underlying functional recovery. We propose an interpretable, causal-discovery-guided framework for deriving a hierarchical Sleep Recovery Score (SRS) from multimodal PSG. Using two large population cohorts (MESA: $n=1{,}540$; MrOS: $n=825$), we apply directed acyclic graph (DAG) learning to identify candidate physiological drivers spanning respiratory burden, hypoxic burden, sleep fragmentation, sleep architecture, and autonomic regulation. Although derived from clinical PSG, these domains map naturally to sensing streams increasingly available in connected health technologies, including wearable ECG, oximetry, and sleep-stage estimation devices. To preserve mechanistic plausibility, we introduce a two-stage screening process that combines physiology-based constraints with constrained LLM-assisted auditing to identify and remove structural confounders and construct-overlapping variables. Across cohorts, these five domains emerge as recurrent physiological domains associated with recovery, and the resulting SRS shows up to $3.4\times$ stronger alignment with perceived recovery than AHI. By linking multimodal sleep physiology to patient-centered outcomes through an interpretable, bias-aware, and domain-structured framework, this work provides a practical foundation for recovery modeling across both clinical sleep studies and emerging smart and connected health settings.

Language models are remarkably capable at medical question answering, in some cases surpassing the accuracy of general physicians. However, answering questions about wearable health data remains challenging and understudied, as these ubiquitous sensors produce continuous, high-dimensional, and longitudinal data, which is non-trivial to align with text-centric distributions in LLM pretraining. The diversity of sensor modalities and user intents cannot be effectively handled by a fixed reasoning workflow or a single pretrained foundation model. To address these challenges, we propose WEQA, a query-adaptive agent framework that unifies LLM reasoning with specialized wearable analytical and modeling tools. An LLM controller is employed to synthesize execution plans and dynamically route each query to the appropriate combination of sensor analysis and pretrained models, and perform grounded response auditing with external knowledge. We also curate a benchmark spanning four open wearable datasets comprising analytic and predictive tasks in three different health domains. Experiments show that our framework is 24% more accurate than LLM and agentic baselines, and a blinded study with 12 medical experts and 8 users shows substantial gains in usefulness and clinical soundness.

A robot's flash endurance is a non-renewable stock: every persisted write spends one of a few thousand program/erase cycles and never refills, yet no fielded robot memory system prices which memories are worth an erase cycle. We treat embodied memory as depreciating capital and price that stock with a single endurance shadow price $η$, which makes cost-minimizing placement across a RAM / on-board NVM / cloud hierarchy a threshold in a wear-augmented per-byte index. The index is cost-optimal whatever the sign of the value-write association $χ$; only when $χ> 0$ does the optimum turn non-monotone, sending a robot's most valuable memories off its flash. The pivot is thus empirical, and we measure $χ$ on real robot logs at a pre-specified gate: its sign is a property of the deployment regime -- positive on recurrent long-horizon manipulation ($\hatχ \approx +1.0 \times 10^{-3}$, replicated at full power), null on a shorter-horizon suite, and negative on non-recurrent teleoperation. Two boundaries scope the result. The endurance budget is dormant on premium 3,000-P/E TLC at datasheet prices and binding on the commodity QLC/eMMC ($\sim$1,000 P/E) that cheaper edge robots run. And where it binds, a learned wear-aware controller only ties price-based routing on task value, because realized value is tier-invariant across RAM, NVM, and cloud: the rent governs device lifetime and cost, not task performance. Whether wear-aware placement improves task value remains open -- $χ$ is measured against a value proxy, and the non-monotone optimum, while proven, is not yet observed in data.

Personal health data from wearables are typically presented through dashboards of charts and summary statistics, requiring users to actively interpret patterns and implications. We explore an alternative interaction paradigm: engaging with personal health data through an embodied conversational agent that facilitates objective data reflection in dialogue with the user. We present a system that combines lightweight preprocessing of wearable data with a Unity-based embodied character. Internally, the system follows a dual-agent design in which an Observer agent extracts descriptive statistics and temporal trends, and a Presenter agent communicates these findings through "spoken statistics," intentionally refraining from clinical advice to isolate the impact of the interaction modality. We evaluate this approach through a simulated-self user study (N=5) using a within-subject design. Participants adopted health personas and goals derived from the LifeSnaps dataset to compare traditional dashboard exploration with embodied conversational reflection. Our evaluation focuses on perceived understanding, the specificity of generated actions, and the cognitive shift from passive viewing to active sensemaking. The paper contributes a functional prototype, a design pattern for objective health data narrative generation, and early empirical insights into how embodiment affects the interpretation of personal health metrics.

Nanopores are versatile single-molecular sensors, but their utility is fundamentally constrained by stochastic translocation dynamics warping any encoded information. We resolve it by shifting from time-domain analysis to a learned latent-space mapping via a contrastive encoder trained exclusively on simulated signals from a physics-informed model. This encoder maps solid-state nanopore signals of engineered DNA barcodes into an interpretable molecular coordinate system. The learned representation is responsive to structural barcode parameters while remaining invariant to acquisition conditions and translocation conformation, allowing data pooling across devices. Molecule identification requires a single pass through the encoder, reducing computational cost by three orders of magnitude relative to alignment-based methods. We experimentally validate through mixture quantification, rare-variant detection, consensus barcode reconstruction, and real-time signal acquisition. This shift from temporal analysis to mapping structural coordinates into a latent space changes the paradigm behind analyzing stochastic sensor signals by linking classification to interpretable encoded molecular information.

Embedded devices from wildlife monitoring stations to clinical wearables require local AI inference due to latency, communication, or privacy constraints. Optimizing models for heterogeneous microcontrollers (MCUs) requires simultaneously satisfying hard physical constraints on memory, power, and temperature while preserving accuracy, a multidimensional optimization that is today performed manually by experts. We ask whether an LLM agent can autonomously navigate this complex, multi-turn pipeline guided by real hardware feedback, and introduce a hardware-in-the-loop agent arena in which the agent iteratively refines both model and firmware -- compiling, flashing, and measuring on real hardware -- to enable closed-loop optimization. Frontier models, including Claude Opus 4.7 and Gemini 3.1 Pro, fail entirely without hardware feedback (0% deployment success), whereas our hardware-in-the-loop formulation achieves the first successful deployment within three iterations and can surpass human expert results within seven. This agentic co-optimization achieves 250x compression for vision models with <3.3% accuracy loss and 400x for audio with <6% Feature Error Rate loss, enabling battery-free operation on a commercial MCU via solar harvesting. We demonstrate practical impact in two real-world systems: an elk-detection camera trap (96.7% accuracy) and a phonetic-transcription wearable (8.44% FER) for child development research.