Synthesis

Chemistry literature synthesis often requires assembling specific findings scattered across many publications, yet existing literature-search systems primarily return ranked document lists. As a result, scientists and AI agents need to locate relevant information, verify their provenance, and assemble cross-paper answers manually. We present AskChem, a claim-centered infrastructure for cross-paper chemistry search. AskChem changes the unit of retrieval from the paper to the provenance-carrying claim: each paper is converted into atomic, typed claims, each grounded by a source DOI and a verbatim quote or an explicit evidence locator. Over this shared claim store, AskChem exposes complementary structures for search and synthesis: a stabilized faceted taxonomy for hierarchical retrieval and browsing, an evidence graph linking claims through relations, and an exploratory living taxonomy that situates indexed papers under scientific principles. AskChem currently indexes 2.4M claims from 147K papers and provides a web interface, as well as REST, SDK, and MCP access for AI agents. On AskChem-Bench, grounding a GPT-5.5 reader in AskChem yields 100% resolvable DOIs, compared with 88.3% without retrieval, and the highest citation density among five tested systems. AskChem is live at https://askchem.org.

Microservice architectures have become dominant for modernizing monolithic systems, yet identifying appropriate services remains challenging and largely manual. Existing decomposition approaches are predominantly code-centric, limiting applicability in early design stages where only textual requirements are available. Despite advances in Large Language Models (LLMs), limited empirical evidence exists on their ability to synthesize complete microservice architectures from natural-language requirements, including service definitions and inter-service interactions. This study investigates whether an LLM can bridge requirements engineering and architectural design, generating architectures solely from textual requirements and evaluating structural agreement and perceived quality of results. We conduct a mixed-method study using OpenAI o3 under zero-shot (ZS) and few-shot (FS) prompting across two systems (Bookstore, PetClinic), one execution per system/condition. Architectures are evaluated through (i) comparison with reference architectures using precision, recall, and F1-score for service identification and communication recovery, and (ii) a blinded expert assessment of correctness, completeness, modularity, and plausibility, plus open feedback synthesis. OpenAI o3 identifies services with higher agreement under FS prompting (F1 = 0.79 for ZS versus = 0.97 for FS). Communication recovery is more challenging: ZS produces dense architectures with high recall but low precision (F1 = 0.61), while FS improves agreement, reaching F1 = 0.82 and reducing unsupported dependencies. Expert evaluation corroborates these results, with FS architectures perceived as more modular, coherent, and plausible than ZS outputs. OpenAI o3 shows potential for requirements-driven synthesis when guided by exemplar prompting. Results are model- and context-specific from two small systems, not model-independent proof.

Many dexterous manipulation tasks require the object to remain securely held throughout the interaction. From the perspective of hand-object relational motion, such manipulation comprises four canonical skills: grasping, relocation, in-hand rotation, and in-hand translation. Human hands flexibly compose these skills to accomplish complex tasks. Existing approaches, however, model these skills separately with skill-specific action constraints, objectives, or even dedicated hand morphologies, which breaks the compatibility and continuity required for long-horizon composition. In this work, we present a unified framework that models all four skills in a single formulation that shares the same state and action spaces and a common objective structure. This formulation enables straightforward distillation of a single cross-skill policy that performs strongly on every skill, generalizes to unseen objects, stays robust to disturbances, and chains skills seamlessly into long-horizon manipulation. The framework also transfers effectively across different hand morphologies. Overall, our results suggest that different dexterous manipulation skills can be viewed as instantiations of a shared task formulation, revealing the intrinsic consistency across different behaviors.

Ensuring behavioural correctness in communication protocols is a central challenge in distributed software systems, as subtle inconsistencies can lead to deadlocks. In such settings, protocol refinement - the safe substitution of a protocol that preserves correctness and compatibility with other components - is essential. Large language models (LLMs) have demonstrated strong capabilities in code generation and program synthesis, yet lack mechanisms to reliably produce outputs with correct behaviour. Formal specification approaches, such as multiparty session types (MPST), offer rigorous guarantees, including deadlock freedom, but provide limited support for automatically constructing protocol refinements. In this paper, we present Syntropy, a framework for synthesising protocol refinements guided by MPST specifications and LLMs. It incorporates refinement constraints directly into the generation process, ensuring the generated variants satisfy these guarantees. Our comprehensive evaluation indicates that Syntropy achieves 95.6%-99.5% validity while maintaining high syntactic correctness, and produces diverse, non-trivial refinements across multiple LLMs.

High-quality, diverse data are vital for large language models (LLMs) but remain scarce and costly. Data synthesis is a viable alternative and succeeds on closed tasks, yet the humanities and social sciences (HSS) are overlooked, and their open-ended nature makes synthesis challenging. Moving beyond prior capability-centric, fragmented attempts, we adopt a subject-centric paradigm, define the first HSS domain system covering 14 mainstream fields, and introduce HSS-Synth, the first data synthesis pipeline for HSS. HSS-Synth comprises: (1) constructing seed documents from web corpora via multi-step filtering and text refinement evaluated by a judge; (2) specifying "requirements + persona" to backtranslate seed documents into diverse yet faithful instructions with a strict Q&A alignment check; and (3) breaking LLM response limits via teacher-forced Answering that feeds seed documents during response generation to anchor semantics, reduce hallucinations, and preserve tone and integrity. HSS-Synth yields 237k high-quality, diverse instruction-tuning samples that outperform 14 leading baselines on 16 benchmarks. The fine-tuned Qwen3-8B-Base sets a new SOTA and approaches the official Qwen3-8B, improving both human preference and knowledge capabilities without performance seesaws. Extensive experiments demonstrate HSS-Synth's robustness and transferability. Our code is publicly available at https://github.com/pengr/HSS-Synth.

LLM-based agents excel at software engineering tasks where an existing codebase provides context, but constructing a program from scratch remains fundamentally harder. Recent benchmarks such as ProgramBench quantify this gap: given only natural-language documentation and an execute-only binary as a behavioral oracle, even frontier models solve fewer than 1% of instances. Existing frameworks conflate documentation reading, behavioral exploration, and code synthesis into a single pass, causing agents to probe insufficiently, lose behavioral intent as context drifts, and propagate early misinterpretations into the final implementation. Inspired by classical requirements engineering, we argue that behavioral specification elicitation should be a first-class phase that precedes implementation. We present SpecFirst, a two-stage framework that forces the specification elicitation before code synthesis. A dedicated spec agent first probes the binary and combines observations with documentation into a structured specification. Next, a code synthesis agent then uses this specification to drive implementation. This decomposition resolves documentation ambiguities before coding begins and provides a stable behavioral reference throughout synthesis. We evaluate SpecFirst on all 200 ProgramBench instances across four models spanning two families and an order of magnitude of capability. SpecFirst consistently outperforms the single-loop baseline, improving test pass rates by 6.9%-21.3% and binary exploration coverage by 9.4%-18.5%, all statistically significant. Behavioral analysis on code synthesis further shows that a prior specification enables earlier and more sustained code construction. Our results demonstrate that an explicit requirements-engineering phase is an effective paradigm for from-scratch program construction.

Classical grasp quality metrics assume one deterministic friction coefficient and therefore cannot assess whether a grasp maintains force closure across plausible friction values. We present FIRMGrasp, a family of grasp quality metrics that incorporates friction uncertainty through Conditional Value-at-Risk (CVaR). At confidence level $β$, we evaluate the force-closure margin at the mean of the adverse friction tail. This evaluation defines the risk-adjusted margin $\varepsilon^{(β)}$, the inscribed-ball radius of the corresponding grasp wrench space. We prove that $\varepsilon^{(β)}$ varies monotonically with $β$, remains differentiable in the grasp parameters, and certifies that any grasp with $\varepsilon^{(β)} > 0$ achieves force closure with probability at least $β$. Across 1,599 LEAP Hand and Allegro Hand grasps, $\varepsilon^{(β)}$ identifies friction-sensitive grasps that receive high nominal Ferrari-Canny scores, and 53% of the nominally force-closed grasps lose closure in the adverse friction tail. The nominal margin ranks a successful grasp above a failed grasp with probabilities of only 0.53 in the shake test and 0.67 in the pick test, whereas $\varepsilon^{(β)}$ achieves 0.63 and 0.78. At an adverse friction coefficient of 0.2, 70% of grasps with positive $\varepsilon^{(β)}$ withstand a simulated lift and lateral pull, compared with 25% of grasps with positive nominal margin and nonpositive $\varepsilon^{(β)}$. We also synthesize grasps with positive $\varepsilon^{(β)}$ for the RealHand L6 and LEAP Hand, both of which retain the object during adverse-friction lifts. In MuJoCo trials with the RealHand L6, 95% of grasps that establish contact and have positive $\varepsilon^{(β)}$ retain the object at the same adverse friction coefficient.

We introduce MicroZoom, a generative framework for gigapixel image synthesis at the microscopic scale. Given a standard photograph and a sparse set of consumer-grade microscope close-ups, MicroZoom synthesizes a seamless, gigapixel-resolution image grounded in the material character of the real references, enabling exploratory visualization of microscopic texture across the full spatial extent of an object. Our goal is plausible synthesis, not exact reconstruction. We focus on full-image, reference-based, extreme-scale super-resolution at magnification levels of up to 350x, a setting that introduces two major challenges: (1) recovering texture-specific detail from highly lossy inputs near ambiguous material boundaries, and (2) preserving correct large-scale pattern structure, such as the repeating geometry of a fabric weave, across millions of local predictions. We address these with a two-stage cascaded design, where the first stage recovers global pattern coherence and the second refines local texture detail, supplemented by a segmentation mask to guide synthesis at ambiguous boundaries. We verify our approach on a collection of self-captured everyday objects and demonstrate globally coherent, materially grounded gigapixel imagery.

Electric joint systems are significant elements of an underwater manipulator for its actuation, drive, and control. Working in an underwater environment, the joints suffer huge ambient pressure. To withstand it, the pressure compensation method is usually deployed, whereas the pressurized oil introduces sealing problems as well as parametric uncertainties and unknown disturbances for the dynamic model of the joint. To tackle these issues, this study proposes a design framework for the underwater oil-filled electric joint. The dynamics of the pressure compensation module is analyzed and the structure of the joint is optimized to seal the internal hydraulic oil. An uncertainty dynamic model of the oil-filled joint is established and a robust position controller is designed based on the structured singular value synthesis (mu-synthesis). Experimental results validate the feasibility of the proposed methods.

Chain-of-thought (CoT) prompting can fail severely on constraint-dense logical reasoning tasks, where unverified errors accumulate silently across steps. We introduce SymStep: an LLM makes one atomic claim at a time (DEDUCE: Alice, pet, Cat), then a lightweight constraint propagator checks the claim for consistency with prior accepted deductions, rejects contradictions, and cascades implied facts automatically. SymStep+G additionally provides MRV guidance after each accepted step, directing the LLM toward the most constrained unresolved variable. On a 35-puzzle retained subset of ZebraLogicBench, a benchmark of 1,000 Einstein-style logic puzzles, Direct and CoT both achieve 0%, while SymStep+G reaches 97%. On AR-LSAT analytical reasoning problems, SymStep achieves 100% vs. CoT's 87%. On LGP-14, SymStep+G achieves 100% vs. 0% for CoT and Logic-LM, the strongest prior symbolic+LLM baseline we compare against. Ablation studies reveal that MRV guidance is a key mechanism for reducing directionless cycling, while consistency checking provides a safety net against explicit contradictions. Across six benchmarks spanning five task domains, SymStep variants match or exceed every baseline on constraint-dense and arithmetic tasks. Experiments on AQUA-RAT algebra confirm the advantage is constraint-density-specific.

This paper addresses the modeling and synthesis of constrained robotic system behaviors using Petri nets (PNs). It investigates how to construct models in which all observable system states satisfy given logical constraints while remaining consistent with executable transition semantics. To answer this, we introduce the Hyper Petri Net (HyPN) approach, which synthesizes Petri nets from Boolean specifications while explicitly distinguishing between observable markings and underlying Petri net execution. The proposed method introduces an explicit execution semantics over observable states, induced by admissible (atomic) firing sequences, ensuring by construction that all observable markings satisfy the constraints and revealing a fundamental mismatch between logical feasibility and executable behavior. This is demonstrated in two scenarios inspired by a lunar rover system. These results are particularly relevant for the design of robotic and autonomous systems, as they provide a structured way to ensure correct system configurations while explicitly accounting for execution constraints. The proposed framework further suggests new research directions in execution abstraction, admissible transition systems, and policy selection for navigating between constraint-satisfying states.

While automated research systems promise to accelerate empirical analysis, they are prone to silent failures: instances in which analysis code executes successfully yet relies on invalid causal assumptions. We present the Artificial Intelligence (AI)-based Epidemiology Research Assistant (ARA), a framework that makes these failures visible by explicitly encoding causal design principles, study-specific assumptions, and methodological constraints. ARA integrates protocol construction, synthetic data generation, and adversarial validation into a unified pipeline. The framework translates natural language research questions into structured causal protocols and executable analysis code by first constructing a protocol and then generating synthetic datasets using Structural Causal Models (SCMs) with known ground-truth effects. This synthetic-data step can also support pipeline development when access to confidential data, such as medical data, is restricted. The generated analysis is then evaluated under controlled violations of identification assumptions. We evaluate ARA on the Automated Causal Reasoning Benchmark, assessing recovery of identification strategies, causal quantities, treatment and outcome variables, and consistency between generated code and approved protocol. Protocol construction and adversarial validation did not consistently improve numerical agreement with benchmark estimates compared with standard LLM-based generation. However, they changed the failure mode: instead of silently returning causal estimates, ARA often surfaced protocol concerns, diagnostic failures, incomplete inference, or downgraded non-causal interpretations. These findings suggest that validity-first automated science systems should be evaluated not only by answer accuracy, but also by whether they indicate when causal claims are unwarranted.

Autoregressive text-to-speech models achieve strong naturalness but suffer from slow inference due to sequential token generation, limiting their deployment in production applications that require low latency. IndexTTS-2 is a state-of-the-art autoregressive TTS model consisting of a GPT, a flow-matching Diffusion Transformer, and a vocoder. Despite its high synthesis quality, its inference speed barely reaches real-time without streaming or batching support. We present Faster IndexTTS-2, which accelerates all neural network components of IndexTTS-2 for production deployment on GPUs using NVIDIA TensorRT and TensorRT-LLM. Faster IndexTTS-2 also enables streaming synthesis for latency-sensitive interactive applications, and batched inference across all components to maximize GPU utilization. Experiments on the Seed-TTS benchmark for both English and Chinese demonstrate up to 5.0$\times$ speedup on the autoregressive GPT and 3.6$\times$ end-to-end, with minimal degradation in word error rate, speaker similarity, and naturalness. Our methodology provides a practical reference for efficiently accelerating similar autoregressive speech models on GPUs.

Federated learning (FL) offers a promising approach to privacy-preserving clinical risk prediction, but its deployment remains limited by restricted data sharing, client heterogeneity, class imbalance, and the lack of realistic tabular electronic health record (EHR) benchmarks. Synthetic data generation may alleviate data scarcity, yet its integration with federated optimisation has received limited systematic study. We propose SynPre-FL, a unified framework combining high-fidelity synthetic EHR generation with synthetic-pretrained FL for robust prediction under non-IID conditions. A latent autoencoder-diffusion model generates privacy-preserving synthetic cohorts, which are used to warm-start federated training. This pretraining is followed by heterogeneity-aware optimisation using class-balanced local objectives, proximal regularisation, and adaptive server aggregation. Post-hoc calibration and federated-safe explainability support reliable and interpretable risk estimates. Experiments show that the synthetic generator preserves univariate, bivariate, and multivariate structure while protecting against membership-inference and reconstruction attacks. The generated data achieve strong downstream utility under TSTR, TRTS, and model-based evaluations. Across federated settings with 5, 10, and 15 heterogeneous clients, SynPre-FL consistently improves robustness and scalability over baseline methods, especially under severe non-IID fragmentation. Calibration improves probability reliability, while SHAP analysis produces stable and clinically coherent feature attributions across federation sizes. SynPre-FL therefore provides a practical and reproducible framework for combining synthetic data with FL to enable privacy-aware, interpretable, and robust clinical prediction from distributed tabular EHR data.

Behavior Trees (BTs) are widely adopted for complex task execution in robotics, providing modular, reactive control but lacking formal guarantees. However, existing correct-by-construction synthesis from Linear Temporal Logic (LTL) cannot express quantitative timing constraints. This letter synthesizes correct-by-construction BTs from Signal Temporal Logic (STL) specifications. The workspace is modeled as a timed transition system and abstracted into a zone graph, and an augmented state space tracking both logical progress and timing constraints is introduced. A hierarchical fixed-point algorithm computes winning sets for an STL fragment encompassing safety, reachability, response, recurrence, and persistence, yielding BT subtrees with a runtime constraint function. Correctness guarantees are proven and complexity bounds are derived. Simulations demonstrate specification satisfaction with strictly positive robustness, and a physical quadrotor experiment with six STL specifications validates practical deployability.

We propose a chaos-inspired new architecture for EMG-to-Speech (ETS) synthesis called CS-ETS, which combines a Samba-based encoder with two novel chaos-inspired loss functions -- Lyapunov Exponent Regularization (LER) and Multi-Scale Detrended Fluctuation Analysis (MSDFA). LER is designed based on Lyapunov exponents to capture nonlinear fluctuations and sensitivity to initial conditions. MSDFA exploits detrended fluctuation analysis to quantify fractal-like, long-range temporal chaotic correlation. CS-ETS surpasses prior work with a 40.79% lower parameter count (32M vs 54.1M) and introduces a new Post-Vocoder Alignment approach that improves LSD by 2.1x, STOI by 4.7x, and SI-SDR by 1.25x. CS-ETS reduces computation by 13.33% while maintaining improved performance. To the best of our knowledge, for the first time, we show how ETS can be supervised by the subtle non-linear chaotic physics with Samba attention to achieve a significantly smaller model with superior performance.

Graphical User Interface (GUI) agents powered by vision-language models hold promise for automating real-world mobile tasks. However, progress is limited by the lack of high-coverage, long-horizon interaction trajectories collected from element-rich and rapidly evolving apps. Existing pipelines often rely on costly human demonstrations or on-policy framework, which tends to over-sample common flows while missing rare transitions and complex multi-step procedures. To address this problem, we propose SEE, a two-stage data synthesis framework consisting of (i) an efficient exploration stage that builds an explicit UI transition graph over screens and elements, and (ii) a graph-based synthesis stage that composes diverse multi-step trajectories via planning and controlled sampling. This design yields reproducible and explainable data generation, while explicitly preventing spurious cycles and enabling long-horizon composition. Across multiple real-world apps, SEE produces trajectories with an average length of 14.8 steps while avoiding spurious loops, and agents fine-tuned on SEE achieve improved task success and generalization to unseen screens. We will publicly release our synthesis code and dataset.

Expressive speech synthesis for voice assistants requires flexible style control that adapts to explicit requests and broader interaction context. We propose Harness TTS, a lightweight control layer that wraps around a TTS engine to externalize and govern its expressive behavior. It reformulates style control as closed-set prompt-tool routing: offline, a compact registry of stylistic prompt tools is constructed with structured metadata; online, an LLM planner selects the appropriate tool based on a priority-aware observation schema, and the TTS executor synthesizes speech using the corresponding prompt audio. We evaluate Harness TTS on both routing and synthesis tasks. In routing, Qwen3-4B achieves Top-1 accuracies of 74.3%, 43.0%, and 64.6% on explicit, implicit, and conflict subsets. For synthesis, experiments on CosyVoice3 and VoxCPM2 show that Harness TTS outperforms instruction-only control, achieving higher instruction-following win rates (margins of 23.1-35.6 points on CosyVoice3 and 13.8-20.0 points on VoxCPM2) and improving UTMOSv2 scores by 0.11-0.38. Moreover, the 4B planner delivers its first tool recommendation in under 50 ms in standard mode, introducing negligible latency for real-time interaction. These results demonstrate that equipping TTS engines with a dedicated Harness layer offers a practical, auditable, and context-aware solution for voice assistant expression control.

Direct generation of Chinese vector fonts is a challenging and ongoing problem. A Chinese vector glyph contains complex component structure, anchor layout, and Bézier curve details, which work at different scales, but a standard vector sequence writes them together in one long sequence, making the task of vector font synthesis challenging. Existing direct vector generators often fail on complex characters, while raster-domain methods must vectorize the synthesized glyph images afterward. To address the above-mentioned problem, this paper proposes VecFontLLM, an anchor-guided multimodal large language model for direct few-shot synthesis of Chinese vector fonts. Our key idea is to generate vector glyphs through anchors rather than a standard vector sequence. Specifically, the proposed VecFontLLM first predicts and refines an anchor scaffold that fixes the coarse layout of components and contours, and then completes Bézier control points to recover local curvature and style. At test time, a confidence-guided generation chain samples multiple component candidates and continues synthesis from the highest-confidence one, improving stability for complex glyphs. This work demonstrates, for the first time, high-quality few-shot synthesis of complex Chinese vector glyphs directly in the vector domain, without raster generation or vectorization. Experiments on several Chinese font datasets show substantial improvements over existing vector font synthesis methods, competitive glyph rendering quality against raster-domain baselines, and vector command distributions close to real fonts.

We present a practical recipe for building a compact Hindi text-to-speech (TTS) model by distilling a large flow-matching teacher (IndicF5, 337M-parameter DiT) under a severe data budget (~17.6 hours). Training a small model from scratch on this much data fails outright. Instead we warm-start the student from the teacher by pruning depth only: keeping the teacher's width, text dimension, attention heads, and mel/text I/O fixed so all non-block tensors copy one-to-one, and retaining an evenly-spaced subset of transformer blocks. We first measure how much depth the teacher tolerates (it remains near-functional at -27% blocks but collapses past -50%), then descend gradually (22 -> 16 -> 12 -> 8 -> 6 blocks), re-fine-tuning after each prune, with each step gated by an objective ASR word-error-rate (WER) check. The resulting students reach WER 0.00 on unseen sentences at 249M and 190M parameters, and remain robust down to 131M; at 102M we observe a clear capacity cliff that we attribute to the data budget rather than the recipe. We also document two train/inference feature- and library-parity failures (mel filterbank and rotary-embedding library versions) that silently degrade audio, and a version-independent fix. The method yields a high-quality Hindi voice that runs in real time on a 6 GB laptop GPU. An independent 50-sentence FLEURS benchmark compares the released 190M student against its teacher and MMS-TTS-hin.

The deployment of autonomous cyber-physical systems in safety-critical environments requires closed-loop control strategies (i.e., policies) that are not only performant but also provably safe and robust. While learning-based methodologies such as Reinforcement Learning offer flexible and scalable approaches to automatically synthesize such controllers, they typically lack the formal guarantees necessary for safe deployment. To bridge this gap, we propose a novel simulation-based methodology to automatically synthesize policies with formal guarantees regarding performance, safety, and robustness specifications. Specifically, given a set of properties to verify, a confidence parameter $δ$ and an allowable failure probability $\varepsilon$, our method guarantees that the synthesized policy comes with a certificate: with confidence at least $1 - δ$, the probability of encountering a scenario where the given properties are violated is at most $\varepsilon$. We demonstrate the feasibility of our approach by developing SMC-ES, an algorithm that integrates Evolutionary Strategies with Statistical Model Checking-based verification. We evaluate SMC-ES on a suite of continuous control tasks using Gymnasium and Safety Gymnasium testbeds. Results show that, at the price of a sustainable increase in computational cost, our algorithm provides formal guarantees regarding performance, safety, and robustness specifications, while performing competitively against leading model-free Deep Reinforcement Learning (DRL) and Safe-DRL baselines.

Autonomous coding agents increasingly execute multi-step software work, but lifecycle states such as reviewed, tested, DONE, and ready-to-merge remain claims unless supported by current evidence. We present Proof-or-Stop Lifecycle Control, a method that permits lifecycle transitions only when fresh, tracked-source-state-bound, mechanically verifiable evidence satisfies the relevant gate. The method treats agent outputs as claims rather than lifecycle state, and uses proof operationally to mean gate-admissible evidence under a stated trust model, not semantic program correctness. We evaluate an open-source implementation through mechanism tests, a powered control-policy ablation, and operated self-application evidence. The unattended-loop engine passed 10 of 10 scenarios with zero false-DONE, and local-key receipt bundles rejected 18 tamper classes with zero false accepts. In a 9,240-cell ablation, the pre-registered A4 versus A2-prime comparison reduced visible-pass/hidden-fail amplification from 31 of 1,800 injected cells under a compute-budgeted naive loop to 2 of 1,800 under the gated loop, a 1.6 percentage-point improvement in not-amplified rate with a 95 percent confidence interval of [0.8, 2.5]. A near-compute A3 versus A4 comparison, 14 of 1,800 versus 2 of 1,800, indicates that the gain is associated with enforcing review as a lifecycle gate rather than merely adding a reviewer. The self-application corpus contains 565 stories and 1,007 review findings, with 94.8 percent resolved, plus a 68-row high/critical cross-vendor exhibit. These results support Proof-or-Stop as a model-agnostic, host-neutral control layer for deciding which autonomous-agent claims a lifecycle may act on. The evaluation is limited to one model family, 24 ablation tasks, and a self-hosted corpus.

Recent diffusion-based generative models have achieved strong results in domain-specific audio generation tasks such as speech, singing, and instrumental music synthesis. However, these models are typically specialized and do not generalize well to mixed or intermediate audio types. In this work, we adapt a diffusion-based model originally designed for multi-instrument music synthesis to voice conversion, covering both speech and singing within a unified framework. Specifically, we extend musical note-based conditioning to include phonetic posteriorgrams (PPGs) and pitch contours, and reinterpret timbre conditioning as speaker or singer identity via feature-wise linear modulation. Experiments show that the adapted model matches or surpasses a dedicated voice conversion system in terms of naturalness and performer similarity, while maintaining accurate pitch control across speech and singing. At the same time, we observe limitations in phonetic fidelity and a degradation in vocal quality when incorporating instrumental training data. Furthermore, we demonstrate that off-the-shelf feature extractors provide effective conditioning signals, enabling large-scale self-supervised training without manual annotations. These results highlight the potential of cross-domain model transfer towards unified audio generation systems capable of handling speech, singing, and music. Qualitative samples can be found on our project page: https://benadar293.github.io/voice-conversion

Animatronic faces are a central component of socially interactive robots, enabling rich nonverbal communication through facial articulation. However, state-of-the-art animatronic faces are typically tailored systems: each new facial geometry requires extensive manual mechanical redesign, making large-scale personalization prohibitively slow and costly. In this work, we pursue automated and scalable mechanical face synthesis, aiming to rapidly generate a physically realizable facial mechanism for a wide range of facial geometries. We introduce a parametric, linkage-driven mechanical face template whose topology and actuator layout are explicitly parameterized to support systematic scaling and retargeting across diverse facial morphologies. Building on this template, we propose a hierarchical automatic design algorithm that takes a single 2D portrait as input, reconstructs a target 3D face, and synthesizes a collision-free, manufacturable internal mechanism. The algorithm combines anatomy-guided feasible motion volumes, Action Unit (AU)-derived trajectory-based expressiveness objectives, and a collision-driven outer-loop refinement strategy. Beyond hardware synthesis, we argue that future mechanical faces deployed at scale must engage in bidirectional, multi-turn conversation rather than functioning solely as speaking or listening heads. To this end, we develop a dual-identity conversational facial motion synthesis framework that jointly models speaking and listening behaviors from audio, producing temporally coherent 3D facial motion suitable for physical execution. We validate our system through extensive experiments, including (i) quantitative evaluation of automatic mechanism synthesis across diverse facial geometries, (ii) comparisons against manual mechanical design, (iii) benchmarks on conversational facial motion synthesis and real-time deployment, and (iv) perceptual user studies.

Conditional diffusion models can generate anatomically plausible medical ultrasound (US) images, but anatomical plausibility alone does not ensure realistic B-mode appearance. Most US pipelines adapt standard generative architectures and condition them on anatomical masks, or use guidance mechanisms that reinforce the same anatomical signal. However, B-mode US images are shaped by acquisition-dependent properties such as speckle texture, tissue contrast, and attenuation. Using a frozen US foundation model, we show that standard conditional diffusion baselines remain separated from real images in representation space. In this work, we propose Feature-Space Candidate Guidance (FSCG), a training-free sampling strategy to reduce this gap. At sampling time, FSCG applies local k-NN feature correction and selects the best of multiple stochastic candidates according to their feature-space energy. In this way, the mask defines the anatomy, while FSCG steers samples toward the real US domain. Across three different datasets, FSCG reduces average FID64 by 56%, FID192 by 57%, and nearest-neighbour feature distance by 47% over standard conditional diffusion sampling, outperforming alternative inference-time guidance baselines. The results suggest that domain-aware feature representations can reveal and reduce realism gaps in medical diffusion synthesis without retraining the generator. Our code is available at https://github.com/marinadominguez/FSCG.

Recent foundation image and video generation models offer strong generalization and controllability, but their direct application to embodied scenarios is limited by requirements for multi-view consistency, geometric coherence, and robot embodiment constraints. Existing methods typically adapt foundation models with limited robot data, often sacrificing visual knowledge acquired during large-scale pre-training. We present Xiaomi-Robotics-U0, a 38-billion-parameter multimodal autoregressive model for unified embodied synthesis. It treats embodied generation as an extension of foundation image and video generation and jointly optimizes text-to-image generation, image editing, embodied scene generation, embodied transfer, and embodied video generation. This unified framework preserves the generalization of the pre-trained world foundation model while adapting it to embodied settings. Xiaomi-Robotics-U0 is the first model to support high-quality multi-view scene generation across multiple robot embodiments and to introduce structured, controllable embodied transfer for fine-grained editing while preserving multi-view consistency and interaction dynamics. It achieves state-of-the-art results on single-step and sequential generation tasks, outperforming GPT-Image-2.0 in human evaluations of embodied scene generation and transfer, ranking first on World Arena for embodied video generation, and improving the out-of-distribution success rate of pi_0.5 from 36.9% to 63.2% on challenging real-world manipulation tasks. These results show that foundation world models can serve both as embodied world models and scalable data engines for embodied intelligence. Code and checkpoints are available at https://robotics.xiaomi.com/xiaomi-robotics-u0.html.

Multi-scene navigation (clearing an objective in one bounded space and then crossing a portal into the next) is a defining feature of contemporary 3D games, but authoring it is laborious: every portal must have consistent endpoints on both sides, each interior must remain navigable once it is furnished, and the resulting connectivity must be kept consistent across many files. Recent large language model (LLM) and multimodal LLM (MLLM) scene generators have made single-interior synthesis dramatically cheaper, yet they produce one scene at a time and cannot, by naive repetition, yield a connected multi-scene world. We identify three obstacles that single-scene methods leave unsolved: cross-scene consistency, in-scene navigability, and the evaluation of whether a transition actually works. We present MAGIC, a prompt-to-project system that addresses all three. MAGIC is a four-stage pipeline that turns a single natural-language prompt into a runnable multi-scene game project: it plans a shared transition-aware intermediate representation, specifies each scene while enforcing portal reachability with a flood-fill validator, generates the scenes together with their transition scripts, and combines them into one project. Because existing single-scene fidelity metrics never execute a transition, we further introduce a transition-focused evaluation agent that runs each transition in play. On a new benchmark of 100 multi-scene cases, MAGIC produces an executable project for every case and reaches 0.99 precision, 0.95 recall, and 0.96 F1 on end-to-end transition identification; stage by stage, it recovers more ground-truth portals and yields markedly more navigable layouts than an LLM baseline and Holodeck. Our code is available at https://github.com/sereneee1201/MAGIC/.

Open-vocabulary dense perception (OVDP) aims to localize objects unseen during training by leveraging textual knowledge. Despite the remarkable progress of recent CLIP-based approaches, we identify a critical limitation: synonym-induced grounding inconsistency, where semantically equivalent expressions yield disparate spatial attention patterns. This inconsistency undermines the robustness and performance of existing methods in real-world OVDP applications. To address this issue, we propose SynCLIP, a Synonym-Coherent Language-Image Pretraining framework that enhances synonym-robust grounding for OVDP. SynCLIP introduces a Semantic-consistent Spatial Attention alignment (SSA) module to enhance spatial attention consistency by minimizing discrepancies between attention maps of original and synonymous expressions. Furthermore, a Spatial Attention Refinement (SAR) module selectively strengthens the most semantically relevant spatial regions within aligned maps for more precise and stable grounding. To support synonym-coherent pretraining, we also construct a Synonym-Enriched Visual Corpus (SEViC), which augments each category with multiple synonyms and textual definitions. Extensive experiments on multiple benchmarks demonstrate that SynCLIP substantially improves grounding consistency under diverse linguistic variants and achieves state-of-the-art performance among CLIP-based OVDP methods. Code is available at https://github.com/Justlovesmile/SynCLIP.

Metal-organic frameworks (MOFs) offer a highly modular platform for adsorptive gas separation, yet their vast reticular design space makes inverse design difficult under simultaneous constraints of chemical validity, separation performance, and structural diversity. Here, we present LEMO Agent, a large-language-model agent framework for closed-loop inverse design of gas-separation MOFs in MOFid space. LEMO Agent couples language-based candidate generation with MOFid standardization, explicit validity checking, Transformer-based property prediction, structured design memory, and multi-island exploration. Through iterative generate--validate--evaluate--remember cycles, the agent uses feedback from both successful and failed candidates to guide chemically constrained search across linker, metal, and topology choices. We evaluate LEMO Agent on CH$_4$/N$_2$ and CO$_2$/N$_2$ separation tasks. Compared with representative generative, optimization, and agentic baselines, LEMO Agent enriches high-performing candidates, improves predicted separation performance, and maintains broad chemical and topological diversity. Selected candidates are further reconstructed, evaluated by GCMC simulations, and passed through an experimental down-selection workflow based on chemical feasibility and ligand purchasability, leading to initial wet-lab synthesis and SEM characterization. These results demonstrate that large language model agents can serve as interpretable and scalable design engines for accelerating MOF discovery beyond conventional fixed-library screening.

Industrial sound design requires audio generation systems that not only produce realistic audio, but also preserve the perceptual identity of a reference, support controllable variation, and remain efficient for practical workflows. Existing evaluations are usually tied to text-to-audio (TTA), unconditional, or task-specific settings, limiting assessment for reference-guided sound effects (SFX) variation. To address this gap, we present a production-oriented evaluation framework for structured comparison of heterogeneous audio generation and editing methods. Our framework identifies nine production requirements and explicitly accounts for differences in model capabilities, enabling comparison under a common production objective. A two-stage protocol is introduced: (1) a reference-guided audio-to-audio (ATA) variation task, in which all methods are evaluated under the same ESC-50 SFX adaptation setup, and (2) capability-specific analyses of native operations such as SFX morphing, temporal and energy alignment, inpainting, and targeted editing. This framework combines objective metrics (including FAD, ImageBind-based reference alignment, and diversity across generated variants), together with a human study of perceptual identity preservation and transient diagnosis. Our study reveals complementary strengths and trade-offs across baselines for different production needs. Among the full-generation baselines evaluated under a shared ATA setting, AudioX provides the strongest overall trade-off between reference alignment and diversity while still supporting SFX morphing. Other baselines remain most suitable for specific editing operations. Our framework establishes a structured evaluation and decision protocol for reference-guided SFX variation and provides a practical basis for designing future unified industrial audio generation pipelines. Audio demos are on the accompanying web page.

Motivation: Rare disease (RD) diagnosis is frequently delayed due to the similarities in symptoms to common disease variants. Machine Learning Algorithms applied to Electronic Health Records show promise for accelerating the diagnosis; however, legal and privacy concerns pose significant barriers. To address these issues, Synthetic Data Generation is an alternative method for obtaining Electronic Health Records and can be applied with any Machine Learning algorithm for benchmarking and development purposes. Despite the availability of Synthetic Data Generation algorithms, support for generating a subset of patients that differ in a definable degree from the majority to simulate patients with RD is often lacking. Results: We present SYNRARE, a graphical user interface based on the Synthea framework that enables easier modification and generation of synthetic Electronic Health Records of RD patients, which differ only to a definable degree from patients with common diseases, thereby enabling the benchmarking and testing of algorithms under controlled technical conditions. SYNRARE enables researchers to rapidly benchmark their Machine Learning algorithms across any scenario. Availability and implementation: SYNRARE, including detailed instructions for installing, is available at https://gitlab.sdu.dk/screen4care/synrare.

In this study, we present a large-scale descriptive analysis of the use of an AI-based learning assistant (Syntea) in higher education. Based on objective log data from 77,543 students enrolled in distance studies, we examine usage patterns across gender, age group, study cluster, degree, and study mode. To date, existing research on educational chatbots has largely relied on comparatively small samples and self-reported survey data, while large-scale evidence on actual usage behavior remains limited. Our findings show that Syntea is already embedded in the study routines of many learners, but that usage differs across demographic and structural contexts. By identifying these patterns, our study provides an empirical basis for the further development of AI-based learning support and contributes a large-scale analysis of educational chatbot usage in higher education.

Safety evaluation for autonomous driving is dominated by rare, safety-critical interactions, motivating simulators that can deliberately synthesize corner cases with photorealistic observations. Corner-case generation is inherently a multi-source problem spanning visual representation, scene reasoning, and vehicle trajectory generation and control. Prior knowledge- and model-based approaches typically focus on scene or trajectory components in isolation, while diffusion-based methods attempt end-to-end generation but still struggle to ensure spatiotemporal consistency and physical realism. To unify these aspects within a single framework, we propose CARLA-GS, a modular corner-case synthesis pipeline that decouples visual representation, semantic reasoning, and physics-based execution while maintaining tight cross-module coupling. Starting from real driving data, we reconstruct an editable gaussian scene with additional geometry-consistent constraints. A multi-agent LLM then performs scene-level reasoning to identify risky interactions and generate intent-level waypoint trajectories, while the low-level motion control is delegated to CARLA, where a PID controller ensures kinematic and dynamic feasibility. The simulated vehicle states are finally re-projected into the gaussian scene for ego-centric rendering. This design enables high-level semantic reasoning, low-level physically executable motion, and photorealistic corner-case generation within a unified pipeline. Experiments on the Waymo Open Dataset show, both quantitatively and qualitatively, that our framework enables controllable corner-case generation and produces photorealistic, spatiotemporally consistent videos aligned with semantic intent and physically feasible motion.

LiDAR semantic segmentation is a key perception task in autonomous driving, where false predictions can affect downstream planning and safety-critical decision-making. Although adversarial attacks, and specifically adversarial examples, have been widely studied for image classification and 3D point cloud segmentation, unrestricted adversarial examples remain largely unexplored in the space of 2D range images, which are projections of 3D point clouds. The proposed method is, to the best of our knowledge, the first diffusion-based unrestricted adversarial attack against 2D range-image segmentation, using adversarial guidance from a segmentation loss. By applying guidance directly during sampling, the method produces unrestricted adversarial examples that remain close to the learned LiDAR data manifold while inducing structured segmentation errors. Experiments on the SemanticKITTI dataset using RangeNet++ and CENet segmentation networks demonstrate that the attack provides adjustable degradation across guidance strengths and transfers across segmentation architectures. Compared with norm-bounded FGSM and SegPGD baselines, the proposed attack offers a distinct effectiveness-realism trade-off, achieving controllable white-box and transfer degradation while maintaining competitive distributional and visual realism.

We present a pipeline for constructing maze structures from input patterns such as text or shapes. The central path-synthesis problem is encoded in Satisfiability Modulo Theories as global constraints on adjacency, continuity, and pattern-constrained coverage, allowing each fixed-bound instance to be solved in one call. The resulting path is either a planar, self-avoiding route or a layered traversal with prescribed over--under crossings, and it serves as a scaffold for constructing planar mazes and three-dimensional realizations of woven mazes. This report extends the published Bridges 2026 conference paper with more representative SMT-LIB examples and a fuller account of how synthesized paths become concrete maze constructions in planar and three-dimensional form.

Sand boils on earthen levees are safety-critical defects, but pixel-level detection is limited by scarce annotations. We present a diffusion-based synthesis pipeline for low-resource sand-boil imagery. Using Stable Diffusion XL fine-tuned with DreamBooth and conditioned by a multi-branch ControlNet stack, the pipeline generates synthetic inspection images from a small curated reference set. A soft-mask inpainting protocol preserves the real defect pixels while re-rendering the surrounding scene, avoiding seams and color shifts from prior seamless-cloning compositing. A mask-conditioned ControlNet can also generate a new boil inside a chosen mask, making the mask the segmentation label by construction; however, because large-scale label certification remains unresolved with the available real-trained gate, we release the soft-mask preset as the default. Text conditioning is supplied by a taxonomy-driven Prompt Atlas that expands one domain specification into a stratified, CLIP-validated prompt bank and transfers to new defect classes without code changes. From the real training images, the pipeline produces 1,020 synthetic candidates, of which 815 pass a CLIP admissibility filter. We evaluate image quality using distributional and fidelity-diversity measures against the real reference set and a Poisson baseline, and audit for out-of-distribution drift and memorization. No single preset dominates; each trades off fidelity, diversity, and label reliability. We therefore release the label-reliable preset as the default and treat a curated mixture as the natural augmentation set. Our claims are limited to image quality, label provenance, and diversity; downstream segmentation is left for future work. Code and an artifact manifest are released for reproducibility.

The synthesis of safety-critical scenarios (SCS) and their evaluation through closed-loop simulations are crucial for developing robust autonomous driving systems. A key aspect of this process involves editing agent states in both appearance and trajectory levels within existing scenes. However, current methods struggle to preserve data fidelity after scene editing and fail to efficiently generate high-quality SCS through such modifications. To overcome these limitations, we propose OmniSCS, an innovative system that generates photorealistic SCS with high physical fidelity while enabling closed-loop testing in synthetic environments. OmniSCS comprises two key modules: 1) A Fully Editable Driving World Construction module that maintains high-fidelity agent appearance and background during scene editing via dual-strategy agent reconstruction and depth-refinement background reconstruction methods. 2) A SCS Synthesis module that facilitates object insertion and agent trajectory editing to synthesize diverse SCS while preserving data fidelity. Experiments on nuScenes, Waymo, and KITTI datasets show that OmniSCS outperforms state-of-the-art methods in edited scene fidelity. We further validate its ability to enhance autonomous driving algorithms and support real-time (13Hz) closed-loop testing. Overall, OmniSCS provides a safer, more effective, and cost-efficient solution for SCS optimization and testing in autonomous driving.

Large language model (LLM) agents are increasingly evaluated on their ability to use tools, plan multi-step tasks, coordinate with other agents, and operate over extended horizons. Reported benchmark gains often obscure recurring failure modes documented across otherwise unrelated evaluation efforts. This paper synthesizes 27 benchmark, taxonomy, and audit papers (2023-2026), spanning 19 distinct benchmarks, into a cross-cutting taxonomy of agent limitations. To our knowledge, this is the first synthesis that integrates evidence across tool use, planning, long-horizon reasoning, multi-agent coordination, safety, and measurement validity into a single, unified taxonomy of LLM agent limitations. We identify six failure clusters: (1) tool invocation and parameter-level errors, (2) planning and constraint-satisfaction failures, (3) long-horizon degradation from context accumulation, (4) multi-agent coordination failures, (5) safety and security failures under adversarial or underspecified conditions, and (6) measurement validity problems. The taxonomy was derived iteratively by grouping independently reported error categories into themes corresponding to distinct stages of the agent reasoning-to-action pipeline. Across the literature, we find that failures compound nonlinearly with task length, that strong performance on individual sub-tasks does not reliably translate into end-to-end success, and that additional scaffolding does not consistently improve reliability. At the same time, substantial progress has been demonstrated in single-turn tool use, short-horizon web navigation, and narrowly scoped coding tasks.

Synthesis planning aiming to find pathways of reactions for a target molecule is one of the most important and challenging tasks in drug discovery. Recent progress has produced both specialized deep-learning retrosynthesis systems and general-purpose large language models, but objective comparison remains difficult due to the lack of flexible, chemically interpretable benchmarking protocols. In the current study, we are introducing the URSA (Utilitarian RetroSynthesis Assessment) evaluation framework that provides the opportunity to benchmark the synthetic routes not only from a formal perspective, such as convergence to commercially available starting materials, but also from a chemical plausibility perspective, mimicking the way expert chemists evaluate the reactions and routes. The study covers a comprehensive evaluation of both conventional end-to-end retrosynthesis solutions and LLMs for the synthesis planning task on a set of novel, diverse target molecules with undisclosed synthetic routes, which represent realistic tasks in the daily drug design routine. We find that while LLMs can support high-level strategic planning, they currently underperform specialized retrosynthesis models in reliably solving synthesis planning tasks.

Dexterous grasping across diverse object scales requires contact modes ranging from two-finger pinches to bimanual grasps. Existing dexterous grasp synthesis methods reduce the high-dimensional optimization space with manually designed expected contacts and initialization heuristics, which struggle to balance synthesis success rate and diversity. We present HUGS (Human-prior-guided Unified Dexterous Grasp Synthesis), a human-prior-guided framework for unified dexterous grasp synthesis across modes and scales. Instead of directly retargeting human demonstrations, HUGS learns an object-conditioned human prior that captures human grasp preferences and guides downstream force-closure-aware optimization. The prior is trained on a compact self-collected human grasp dataset with 1.8K grasps over 304 objects, providing broad coverage of object scales and contact modes. During synthesis, HUGS adaptively proposes contact modes and wrist initializations, substantially improving the balance between contact-mode coverage and synthesis success rate over heuristic-based methods. With HUGS, we synthesize 3.2M robotic grasps over 157K scenes, spanning object half-diagonal lengths from 2 cm to 30 cm and modes from two-finger to bimanual grasps. Models trained on the synthesized dataset autonomously select appropriate contact modes in the real world, enabling grasping from screws to large boxes.

Novel View Synthesis (NVS) enables the generation of unseen views of a scene from a single or multiple images, allowing users to freely explore an object from any viewpoint. Despite the recent impressive qualitative improvements of generative models for this task, existing methods struggle to provide global and intuitive control of target viewpoints because they either use input-relative camera poses or are limited to generating sparse global views. This lack of global pose control severely limits the number of downstream tasks potentially enabled by NVS. To address this limitation, we propose a novel approach for precise camera control in a customizable Normalized Object Coordinate Space (NOCS), requiring single or few unposed images. Our method operates solely on the absolute camera pose of the target view in NOCS, eliminating the need for a relative world frame or camera poses of the input images. Unlike previous methods that treat NVS as a standalone generation task, we formulate it as an image editing problem and build upon state-of-the-art editing models to leverage their superior generalization capability. Camera information is injected as dedicated camera tokens via an in-context multi-modal conditioning strategy. To alleviate the inherent ambiguity of NOCS, we incorporate text descriptions that explicitly define the object's canonical coordinate frame, which also enhances generalization to unseen object categories. Furthermore, we curate a high-quality dataset with consistently aligned orientations and corresponding NOCS text definitions. Extensive experiments demonstrate that our method robustly generates novel views with accurate and consistent orientations from arbitrary unposed images across diverse categories, achieving state-of-the-art image quality and fidelity.

Modern automotive software architectures comprise large sets of mixed-criticality functions executing on shared multi-core platforms with strict real-time and end-to-end timing requirements. Sensor-to-actuator data propagation in such systems is typically expressed via cause-effect chains with worst-case data-age budgets. Job-level dependencies (JLDs) have been introduced to provide a schedule-agnostic mechanism for bounding the data age independently of the underlying scheduler. The state-of-the-art methods for synthesizing JLDs, however, do not check whether the produced JLDs are enforceable under a concrete scheduling policy or jointly schedulable at the system level. In this paper we propose the first machine-learning-based JLD synthesis method, built around a two-level Graph Neural Network with temperature-controlled sampling that learns the structural patterns connecting cause-effect chain configurations to their JLD solutions. Since learned outputs may not be correct by construction, we embed the GNN in a novel Generate-and-Verify architecture in which a safe DP data-age checker, together with a per-chain EDF feasibility checker and a system-level demand-bound test, accept or reject each candidate. We show that the ML-based generator substantially outperforms the original greedy heuristic while achieving orders-of-magnitude lower synthesis time, demonstrating that learned structural priors can effectively replace exponential propagation-tree enumeration on this class of real-time scheduling problems.

Synthetic data can be scaled along two routes: Source Expansion (SE), which enlarges the source by adding seed materials or generators, and Fixed-Source Synthesis (FSS), which holds the source fixed and scales the generation budget. Existing scaling studies typically expand the source as the data grows, conflating SE with FSS and leaving FSS underexplored. We isolate FSS by holding the seed-question pool and teacher model fixed, varying only the per-question response budget under Rejection Sampling (RS). We adapt the rectified scaling law to FSS, deriving it from how repeated sampling covers a fixed source. Empirically, the derived form, fit on low budgets, predicts performance at the held-out highest budget for every evaluated teacher--student pair. At matched total-sample budgets, SE and FSS are comparable at small budgets; at large budgets, adding seed questions outperforms spending the same budget on more responses. Within FSS, however, neither synthesizing additional questions from the existing seeds nor varying the synthesis protocol outperforms plain RS at matched budgets. FSS is thus a bounded scaling axis and a controlled setting for comparing synthesis protocols. We will release our code and data to facilitate further research.

We present SynLaD, a latent diffusion framework for small-molecule generation that unifies ligand-based drug design objectives (what to make) with synthetic accessibility (how to make it). Current models typically optimize one objective at the expense of the other, creating a bottleneck for discovering high-scoring and synthesizable molecules. SynLaD combines reaction-constrained generation with pharmacophore-conditioned 3D design by learning a latent space that decodes to both 3D structures and synthesis pathways. An encoder maps molecules to a latent representation used by two decoder heads: (i) a geometric head that reconstructs atom types and coordinates and (ii) an autoregressive synthesis head that outputs synthetic routes in a serialized, reaction-based notation. A diffusion transformer generates novel latents in the learned space, conditioned on pharmacophore profiles. Across analogue generation tasks for bioactive ligands, SynLaD outperforms existing baselines in synthesizable and diverse hit generation, demonstrating that a single model can produce shape-aligned molecules with feasible synthesis plans.

Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost. We show that this blind spot misranks models: across 11 architectures, models with comparable pointwise error diverge by up to 53° in phase accuracy, equivalent to roughly 123 ms for a 1.2 Hz cardiac rhythm and invisible to standard metrics. To enable development of models that escape such failures, we introduce TimeSynth, a controlled benchmarking framework with two reusable components: a physiologically grounded generator producing signals with analytically known ground-truth dynamics from parametric models fitted to real electroencephalography, electrocardiography and photoplethysmogram signals, along with diagnostics quantifying amplitude, frequency, phase, and state-transition fidelity. Linear and full-sequence attention models systematically lose frequency and phase information despite acceptable amplitude error, whereas architectures with localized temporal structure better preserve dynamical fidelity and adapt to observable state transitions; none, however, reliably preserves stochastic switching. Because the dominant determinant of fidelity is architectural, model choice becomes a principled, use-case-driven decision rather than a search for a single winner. TimeSynth thus supplies the controlled preclinical stress test missing before models are coupled to patient data, with a reusable generator and diagnostics for fidelity-aware development.

Mounted butterflies are among the most striking objects in natural history collections. However, their beauty is notoriously hard to digitize in 3D: they are small and fragile, with microscopic hairs and vein structures. Capturing them in sufficient detail, therefore, requires a macro lens, which has a very limited Depth of Field (DoF). Moreover, a camera body cannot be maneuvered beneath a pinned specimen to photograph its ventral surface (the underside of the wings). We introduce an end-to-end pipeline that resolves these challenges to turn such specimens into photo-realistic 3D models viewable from every direction. It combines three ingredients: handheld focus stacking for all-in-focus macro capture without a tripod, a non-contact first-surface mirror system that exposes the ventral surface without touching the specimen, and a segmentation-free, mirror-aware 3D Gaussian Splatting extension. We validate the reconstructions on four diverse specimens.

While neural network control policies are powerful, their deployment on safety critical systems depends on ensuring that they obey strict constraints. Existing work often treats safety as a metric to optimize for, which competes with other performance objectives, if training converges at all. Instead, we introduce ShardNet, a neural network architecture that strictly enforces unions of polyhedral constraints by construction, using a differentiable projection layer parameterized by a classification network. The key insight is to embed safety into the neural network's structure, allowing performance to be optimized independently because formal safety guarantees are always given. In contrast with existing neural architectures that can only enforce simple convex constraints, ShardNet enables the first safe-by-construction synthesis of forward-invariant neural network controllers on closed-loop systems where safety constraints are expressed as nonconvex unions of polyhedras or learned value function level sets. To support this, we also introduce a technique to verify and train such value functions correctly as rectified linear unit (ReLU) networks, which has not previously been possible. On double integrator benchmarks drawn from the literature, ShardNet policies maintain 100% safety on verified sets and achieves significantly lower objective loss compared to existing formal methods. Furthermore, our value function training technique also produces safe sets more than 3 times larger than existing verification approaches.

Time Window Temporal Logic (TWTL) is a rich specification language for cyber-physical systems that can compactly express sequential tasks with explicit timing constraints. In this paper, we consider the problem of synthesizing control inputs for discrete-time linear systems subject to TWTL task specifications. Building on the quantitative semantics (robustness) recently introduced for TWTL in [1], we encode the robust satisfaction of a TWTL formula as a set of Mixed-Integer Linear constraints and pose synthesis as a Mixed Integer Linear Program (MILP) that maximizes the robustness degree. We prove that any feasible solution with positive objective value guarantees Boolean satisfaction of the specification. We address two synthesis settings: an \emph{open-loop} formulation that optimizes the full control sequence from the initial state, and a \emph{closed-loop} receding-horizon Model Predictive Controller (MPC) formulation that re-solves the MILP at each step using the current measured state. A key feature of our MPC formulation is a \emph{task-adaptive horizon} that exploits the TWTL Deterministic Finite Automaton (DFA) to determine the active sub-task at each step, limiting the prediction horizon to the remaining window of the current task rather than the full formula horizon, this makes each re-solve significantly cheaper than the initial open-loop solve.

Large language models (LLMs) excel across a wide range of tasks, yet their instance-specific solutions often lack the structural consistency needed for reliable deployment. Workflows that encode recurring algorithmic patterns at the task level provide a principled framework, offering robustness across instance variations, interpretable traces for debugging, and reusability across problem instances. However, manually designing such workflows requires significant expertise and effort, limiting their broader application. While automatic workflow generation could address this bottleneck, existing methods either produce instance-specific solutions without learning task-level patterns, or cannot generalize beyond their training configurations. We present MetaFlow, which casts workflow generation as a meta-learning problem: given a task and an operator set, the model learns to compose solution strategies. MetaFlow trains in two stages: supervised fine-tuning on synthetic workflow data, followed by reinforcement learning with verifiable rewards (RLVR) that uses execution feedback across problem instances in the task to improve end-to-end success. The resulting model produces effective workflows for trained tasks and exhibits strong generalization to untrained tasks and novel operator sets. Across benchmarks in question answering, code generation, and mathematical reasoning, MetaFlow achieves performance comparable to state-of-the-art baselines on in-domain tasks with single inference, while demonstrating remarkable zero-shot generalization capabilities on out-of-domain tasks and operator sets.

We propose Nemotron-Labs-Diffusion-Image, a state-of-the-art masked discrete diffusion model (MDM) for high-resolution text-to-image synthesis. Compared with prior work on masked image generation, Nemotron-Labs-Diffusion-Image addresses two key challenges. First, unlike continuous diffusion models which progressively refine latent representations across the entire image, standard MDMs lack self-correcting capability because discrete tokens cannot be modified once they are unmasked. Second, although increasing the vocabulary size of discrete image tokenizers improves reconstruction fidelity, it introduces optimization difficulties for generative modeling as the per-token training signal becomes increasingly sparse. To address the first challenge, Nemotron-Labs-Diffusion-Image incorporates a token-editing mechanism that enables the model to dynamically revise already-unmasked tokens during inference, similar to how a sculptor iteratively refines their work. To tackle the second challenge, we propose a Grouped Cross-Entropy (GCE) objective that assigns positive learning signals to tokens neighboring the ground truth in embedding space, thereby alleviating signal sparsity. To further improve training efficiency, we implement a custom fused operator for GCE that significantly reduces VRAM usage in large-vocabulary settings. Experimental results demonstrate that these innovations substantially improve both training efficiency and image fidelity of masked discrete image generators, achieving a score of 0.90 on GenEval, 86.9 on DPG and 10.76 of HPSv3.

Weather synthesis aims to add weather effects to input videos while preserving scene identity, structure, and motion. The key limitation of existing methods is the lack of diversity in weather appearance and effective control over weather dynamics (e.g., temporal evolution and particle motion). Most approaches rely on text prompts, which are inherently underspecified and often fail to produce detailed weather characteristics. Additionally, general-purpose video editors optimized for clean and aesthetic outputs tend to suppress heavy weather phenomena, making dense particle effects difficult to generate. To address these, we propose a Semantic-Aware, Physics-Informed, and Geometry-Grounded framework that steers an off-the-shelf video editor to synthesize diverse global appearances and detailed particle dynamics. We factorize the synthesis into three conditional signals, so that each provides a distinct and stable source of guidance: semantics specifies what the weather should look like, dynamics governs how it evolves over time, and geometry determines where it should appear in the scene. Specifically, we introduce (1) semantic-aware appearance anchoring to establish the target appearance from scene semantics and user input; (2) physics-informed dynamic simulation to generate particle effects by simulating a Gaussian-represented particle field under gravity, wind, and turbulence; and (3) geometry-grounded video synthesis to align the simulated particles with target scene geometry and synthesize the final video. Experiments demonstrate that our method produces diverse, physically and visually realistic weather effects. Furthermore, we show that our synthesized data significantly improves the robustness of autonomous driving semantic segmentation under adverse weather conditions. Project page: https://jumponthemoon.github.io/w-crafter/.

Leveraging capabilities of large language models (LLMs) in text-to-image (T2I) synthesis is an important research direction. In this work we investigate whether the knowledge of a frozen LLM can be effectively utilized in T2I generation when trained exclusively on standard text-image pairs. We integrate a frozen, reasoning-capable LLM with a diffusion-based image generator via shared attention within the Mixture-of-Transformers (MoT) architecture. Our experiments span two critical questions: (1) what degree of the LLM's intrinsic knowledge remains accessible during T2I training, and (2) what novel capabilities emerge in the resulting system. Across established benchmarks, our models achieve strong performance among unified understanding-generation systems: 0.85 on GenEval, 86.75 on DPG-Bench, and 0.66 on WISE with inference-time reasoning, using only text-image data. Remarkably, we uncover emergent behaviors absent from training data, including cross-lingual image generation, color-guided composition, emoji / ASCII scene construction, and generation directed by world knowledge. These results demonstrate that pretrained LLM knowledge can guide image synthesis under standard text-to-image training paradigms, without interleaved multimodal signals or explicit reasoning supervision. Our findings open new avenues for harnessing frozen model capabilities in resource-constrained multimodal learning.

Ovarian cancer is frequently diagnosed at an advanced stage, making preoperative contrast-enhanced computed tomography (CT) central to staging and surgical planning; yet the scarcity of annotated imaging data, compounded by privacy regulations, limits the development of generalizable computational models in this domain. Text-conditioned 3D CT synthesis has shown promise, but existing pipelines depend on paired radiology reports and have been evaluated only on chest CT. We propose OvESyn (Ovarian Evidence-based Synthesis), a framework that constructs standardized Findings and Impression sections directly from CT-derived imaging descriptors and routine clinical metadata, without any original radiology report, and uses them to condition a latent diffusion model adapted to 493 high-grade serous ovarian carcinoma patients. This is the first text-conditioned 3D CT synthesis framework adapted to an abdomino-pelvic oncologic setting. A systematic ablation over two adaptation axes, vision-language encoder alignment and generator fine-tuning, identifies generator domain adaptation as the operative mechanism for crossing the domain gap and establishing the target anatomy: without it, synthesis remains anchored to the thoracic pretraining domain, with Precision and Recall collapsing to zero and FID2.5D exceeding 140, regardless of encoder alignment. Encoder alignment instead refines intensity and fine detail. The full OvESyn attains the best distributional and intensity fidelity (FID2.5D 29.35, Precision 0.671, Wasserstein-1 0.044), while the generator-only variant maximizes coverage (Recall 0.645), reflecting a fidelity/coverage trade-off governed by encoder adaptation. Requiring only automatic segmentations and routine preoperative metadata, OvESyn supports transferability to report-scarce settings and provides a foundation for synthetic cohort generation in abdomino-pelvic oncologic imaging.

This article addresses the combinatorial complexity inherent in modern high-tech system design by presenting automation-in-design (AiD) as a transformative paradigm. We propose computational design synthesis (CDS), a framework utilising deep learning and generative AI to automate the creation of novel systems. Two case studies (e-drive system design and spatial dimensioning problem) serve as proof-points for this approach. The AI-driven methods used in the case studies represent a fundamental shift in engineering, advancing from simulation-based optimisation towards autonomous design with minimal human supervision.

The interpretation phase of life cycle assessment often lacks structured mechanisms for translating quantified improvement opportunities addressing environmental hotspots into actionable strategic pathways under technological, social, and policy uncertainty. To overcome this limitation, this study introduces a perspective-conditioned retrieval-augmented generation framework for LCA interpretation, where a multi-perspective retrieval and controlled synthesis is incorporated in the artificial intelligence (AI)-assisted LCA. To operationalise large language models in LCA interpretation, a perspective fusion RAG architecture was developed, covering academic, industry, public discourse, and European union (EU) funding datasets. Our approach comprises three steps: (1) a scenario anchor defining system boundaries and decarbonization targets, (2) a set of perspective-specific micro-queries with constrained retrieval, and (3) a neutral synthesis step integrating only ledger-stored outputs without further retrieval. The framework is demonstrated through a hydrogen-enabled diesel reduction use case in an Italian apple production facility using GPT-5 nano as the reasoning model. Overall, the structured retrieval and constrained synthesis are designed to mitigate the risk of hallucination while preserving cross-domain diversity. The approach presented can support more disciplined translation of impact results into strategic pathways and opens up new avenues for the use of advanced AI tools in LCA studies, particularly those focused on technologies that could be deployed at scale. This proof-of-concept demonstrates how AI-assisted, evidence-grounded interpretation can support implementation-oriented decision-making beyond conventional LCA studies.

Order fulfillment in manual picker-to-goods warehouses involves interconnected decisions such as item assignment, order batching, and picker routing. While integrated models capture interactions between these decisions, practical warehouse systems often require decomposed approaches due to organizational boundaries, differing responsibilities, or limited data availability. Existing studies primarily evaluate algorithms for isolated subproblems or fixed subproblem combinations for specific warehouse settings, but lack a general mechanism to determine applicable algorithm configurations, compose them into valid solution pipelines, and assess their performance. With Context-Aware Synthesis of Optimization Pipelines (CASOP), we propose a framework for constructing and evaluating context-specific optimization pipelines and apply these to order fulfillment. The framework comprises: (1) a modular repository of algorithms for common order fulfillment problems; (2) semantic data and algorithm cards to describe warehouse context and algorithm requirements; (3) a taxonomy that structures order fulfillment problems into relevant subproblems; (4) a pipeline synthesizer that identifies applicable algorithms for a given warehouse context and composes all valid optimization pipelines; and (5) a pipeline evaluator that assesses all resulting pipelines. We demonstrate the framework on 7 benchmark instance sets covering four problem classes, resulting in 1,063,044 valid pipelines. The framework supports researchers and practitioners in designing, automatically synthesizing, and selecting valid, high-performing algorithmic pipelines for warehouse operations. The software is open-source and available at https://github.com/kit-dsm/ware_ops_pipes and https://github.com/kit-dsm/ware_ops_algos. Keywords: Warehouse optimization, Algorithm selection, Pipeline synthesis, Order fulfillment

Developing robust artificial intelligence models for 4D (3D + time) medical imaging is constrained by limited annotated data, inter-device domain shifts, and privacy restrictions. To address this, we propose a 4D controllable generative framework for anatomically consistent data augmentation. A semi-supervised variational autoencoder learns a compact latent representation of anatomical volumes while jointly predicting aligned segmentation masks in a unified framework. Anatomical structure is then disentangled from temporal dynamics through a cascaded latent diffusion model (LDM). A static LDM generates subject-specific anatomy conditioned on clinical priors (diagnosis and volumes measures) and a subsequent motion LDM estimates residual latent motions, ensuring strict temporal coherence across the 4D sequence. The proposed approach was evaluated on cine cardiac MRI as a representative 4D imaging application. Experiments across multiple datasets demonstrate high controllability of static anatomy (Pearson r > 0.8) and strong temporal coherence (FVD = 288.08). In cross-vendor generalization experiments, augmenting training sets with synthetic 4D sequences significantly improves downstream segmentation performance. Using nnU-Net, the proposed augmentation strategy improves the average Dice score by 1.4% and reduces the Hausdorff Distance by 3.0mm compared to training on real data alone, for the left ventricle, Dice improves by 2.8% with a 5.4mm reduction in boundary error. Overall, this framework provides a scalable and controllable solution for 4D medical image synthesis, supporting the development of more robust models with limited annotations and cross-vendor variability. Code available on https://github.com/cyiheng/4DCardiacMRISynthesis.

Generic text-to-video models can be used as rich open-world scene priors. Despite the high quality of today's generated videos, they do not directly yield reliable 3D assets: camera motion is difficult to control, view coverage is partial, and frames often contain inconsistencies across time. We introduce OrbitForge, an adapter built from frozen video priors and per-prompt Gaussian Splatting reconstruction optimization that converts a single text-generated video into a canonical closed-orbit 3D Gaussian Splatting scene. We use 3D reconstruction as an anchor to improve the 3D consistency of the generated video. We obtain a preliminary 3D reconstruction from a first generated video via Deformable Gaussian Splatting with a robust MedianGS proxy. We render views from a prescribed orbit to detect missing viewpoints. OrbitForge uses the text-to-video model to complete only the missing views, and reconstructs the completed orbit into a final Gaussian Splatting scene. This design requires no task-specific video or multiview fine-tuning, avoids per-prompt score-distillation optimization, and does not progressively generate views one step at a time. We further argue that this setting demands coverage-aware evaluation: local smoothness alone rewards methods that never attempt a full orbit. On a frozen 300-prompt T3Bench-derived audit, OrbitForge reconstruction attains a 359.0-degree measured median span, raises originally unsupported-bin Q10 ImageReward from 8.07 to 16.36 relative to MedianGS-only reconstruction, while remaining competitive with VideoMV on the coverage-quality.

Retrosynthetic planning seeks to connect a target molecule to commercially available starting materials through a multistep route. Classical planners construct such routes by iteratively applying single-step reaction models within a search procedure; constrained variants often require specialized algorithms or architectural changes. Direct route generation reframes retrosynthesis as sequence generation, but existing direct-generation methods still train separate models for different planning specifications. We introduce Ariadne, a decoder-only route generator that represents the target, optional constraints, and route in one prompt-completion sequence. On the RetroCast/PaRoutes mkt-cnv-160 benchmark family, one 24-layer checkpoint follows route-depth and required-starting-material prompts: adding the corresponding prompt fields raises Solv-0 by 13.7 points for depth constraints and 31.2 points for required-leaf constraints. Ariadne also improves over DESP, a bidirectional search planner, on required-leaf Top-10 and Solv-0 in 24 GPU-minutes versus 6.8 GPU-hours. On standard reconstruction, Ariadne is comparable to DMS Explorer XL at about half the reported inference time. Across additional target-only benchmarks, Ariadne's clearest gains are on route-holdout reconstruction, whereas AiZynthFinder MCTS remains stronger on several Solv-0 comparisons. These results extend sequence generation from specialist retrosynthesis models to prompt-conditioned structural route generation. We release the codebase and training scripts to support further work, but do not introduce Tier-1--3 route checkers; those remain the main bottleneck before models of this kind can become useful to experimental chemists.

Fabric moiré is a sampling-induced aliasing artifact caused by the interaction between fine textile patterns and camera sensor grids, producing structured interference that severely degrades image quality. Unlike screen-induced moiré, which stems from strictly periodic display lattices, fabric moiré is intrinsically more challenging due to the broadband and semi-periodic nature of textile weaves. The heavy spectral overlap between intrinsic texture and aliasing components renders fabric demoiréing substantially more ill-posed. Consequently, existing models trained on screen moiré datasets generalize poorly to these complex textile patterns. Despite its practical importance, fabric image demoiréing remains underexplored and lacks standardized benchmarks. We present the first comprehensive benchmark for fabric image demoiréing. To address the difficulty of acquiring pixel-aligned real-world pairs, we develop a physically motivated synthesis framework and construct a large-scale dataset comprising 16,050 paired multi-resolution fabric images with controllable aliasing severity. Furthermore, we customize a baseline model, which establishes promising performance on the proposed benchmark dataset with strong generalization ability. Our benchmark provides a standardized platform for advancing research in fabric image demoiréing.