Regulation

The widespread adoption of LLMs has led to escalating content compliance risks. Prior works have contributed to addressing these risks in the English context, downplaying the complexity of Chinese language content. This paper follows China's current AI-Generated content compliance requirements and provides evaluation results on 20 notable LLMs, offering insight into China's regulatory landscape. We design a novel framework to assess the compliance and refusal rates with 2303 questions spanning six distinct dimensions, including 203 self-constructed constitutional questions. The framework employs several judges to generate verdicts independently based on their hierarchical alignment memory. Our findings show that international models also exhibit high levels of compliance despite the use of standard Chinese questions, and the main differences may stem from dimensions closely related to ideological alignment. We establish a regulatory benchmark that enables the global AI community to evaluate both Chinese and non-Chinese LLMs under a unified set of legally grounded compliance requirements.

Large Language Models (LLMs) are increasingly adopted for compliance and legal reasoning tasks, yet their outputs often lack explicit grounding in legal logic and evidence. We present Code-as-Auditor, an LLM-based framework that extends the model's reasoning capability toward structured and evidence-grounded compliance assessment. The framework translates regulatory information into (1) formalized checklists and executable decision trees, encoding regulations and conditions as interpretable code structures. During inference, each checklist item is (2) dynamically expanded into factual and counterfactual questions, guiding the model to reason over case-specific evidence and potential violations. This process establishes a reasoning pipeline that proceeds from evidence identification, through rule application, to final decision-making, while a self-verification loop improves the logical consistency of the generated code and the traceability of outcomes. Experiments on privacy and data protection scenarios demonstrate that Code-as-Auditor delivers more accurate and evidence-backed evaluations, enabling automated compliance regulation checking grounded in explicit regulatory criteria.

Compute governance today is a governance of training: the thresholds, reporting requirements, and frontier-AI regimes now in force attach to training compute and treat the trained model as the regulatory unit. That picture is incomplete: capability increasingly migrates to the deployment stage through inference-time scaling, agentic scaffolding, and compression onto consumer hardware. This paper asks which mechanisms are available once the regulatory object shifts from the training run to the inference call. We develop a feasibility taxonomy of twenty inference-time mechanisms across monitoring, verification, and enforcement, each rated on a four-point readiness scale against a documented four-vendor evidence base. We then stress the taxonomy against a two-dimensional adversary model (three capability tiers crossed with four adversary roles) and map each mechanism to four governance scenarios (domestic regulation, bilateral or multilateral coordination, industry self-regulation, and compute-marketplace governance). Fifteen of the twenty mechanisms have commercial technical substrates in production today, although governance-grade assurance and adversarial robustness vary substantially. The adversary analysis shows that this readiness holds only against a cooperative deployer and a low-to-medium-capability user: no mechanism rates adequate against a high-capability state-level deployer, and fine-tuning removes the model-internal components of the enforcement cluster, although platform-external controls can persist. A substitution analysis connects the taxonomy to a companion hardware paper as a conditional substitution principle describing when inference-stage and hardware-stage mechanisms provide comparable regulatory coverage under stated conditions. A second-rater reliability check on a random subset of the readiness ratings returned a quadratic-weighted Cohen's kappa of 0.74.

Artificial intelligence (AI) and natural language processing (NLP) are increasingly used to extract, integrate, and interpret biomedical knowledge relevant to cancer genomics, yet their translation into routine clinical oncology has been comparatively slow. The central challenge is not computational capability alone, but trustworthy integration into clinical workflows. This review examines how NLP and AI support the cancer genomics pipeline, from literature mining and automated variant interpretation to clinical trial matching, knowledge graph construction, and multimodal data integration. We identify four interrelated translational failure domains: evidence inconsistency, explainability and uncertainty, data governance and reproducibility, and interoperability. Rather than considering these challenges in isolation, we take a systems-level view, focusing on their interaction across the translational pathway. We propose a conceptual framework and roadmap for addressing these domains through rigorous validation, uncertainty-aware methods, interoperable infrastructures, regulatory alignment, and human oversight across the AI lifecycle. Progress toward routine clinical use will depend less on further improving model capability than on systematically addressing these interacting failure domains from development through deployment and post-deployment monitoring.

Orchestra composes two independently built bioinformatics MCP servers -- RegNetAgents, which infers gene regulatory network topology from ARACNe networks, and CASCADE, which supplies four independent evidence sources (LINCS knockdown, DepMap essentiality, super-enhancer status, DoRothEA transcription-factor confidence) -- into one multi-agent workflow exposed via the Model Context Protocol. Its central architectural claim is that requiring RegNetAgents' topology evidence and CASCADE's experimental evidence to agree on a candidate regulator yields a more trustworthy candidate than either alone -- not previously tested directly, since RegNetAgents' own validation asked only whether its candidate lists beat chance. We test this on the TCGA tumor-acquired regulator tier (regulators in a gene's tumor ARACNe network but absent from the GREmLN population-averaged baseline), selecting candidates by ARACNe mutual-information (MI) edge weight. On RegNetAgents' published BRCA/COAD focal-gene panel plus matched negative controls, agreement among at least 2 of the 4 CASCADE sources predicts OncoKB cancer-gene status among focal genes (odds ratio 2.89, Benjamini-Hochberg-adjusted p=0.0166) but not among negative controls (p=0.0721); a single source is not diagnostic for either group. The pattern replicates and strengthens in a third cancer type, STAD, on a separately constructed panel (odds ratio 5.82), and against an independently curated ground truth (the Sanger COSMIC Cancer Gene Census). MI edge weight is the strongest single predictor overall (p=0.0003); a logistic-regression likelihood-ratio test confirms corroboration adds value beyond it in both panels (p=0.0234; p=0.0001). Every experiment invokes Orchestra's real agentic entry point.

Text-to-Video (T2V) generative models are vulnerable to jailbreak attacks in real-world deployment, leading them to produce harmful or inappropriate content. Existing defense approaches mainly rely on input filtering or reconstruction, which not only incur high computational latency but also tend to distort semantics. To address these issues, we experimentally and systematically analyze the differences between clean and jailbreak samples in the cross-attention feature space, revealing for the first time a cumulative separation effect and a progressively increasing trend of linear separability between the two during the diffusion process. Based on this insight, we propose SafeCA, a feature-level defense mechanism for safe cross-attention localization and regularization. Firstly, we identify key defensive regions and values through attention stability analysis using cross-attention features collected from clean prompts within a single inference. Secondly, SafeCA mitigates anomalous activations via attention masking with energy normalization and introduces a lightweight semantic-space adapter to redirect abnormal semantic flows. Furthermore, we detect and suppress potentially malicious tokens by back-propagating feature anomaly signals to the input cue words, thereby enhancing the deployability of the defense in commercial models. Experimental results show that SafeCA reduces the jailbreak success rate by about 20% on mainstream T2V models, adds almost no inference overhead (+0.1s), and maintains good text-video semantic consistency. Overall, SafeCA provides an architecture-level, deployable protection paradigm for T2V generation models.

Notice-and-comment rulemaking gives any affected party the same formal right to influence federal regulation, but formal access is not substantive capacity to shape rule text. Existing strategies operate at the rule or aggregate-corpus level, too coarse to capture the discrete regulatory obligations where commenters seek change. We introduce obligation-level responsiveness auditing, an auditable, AI-assisted framework for measuring whether public-comment engagement co-occurs with changes to specific regulatory duties. The framework extracts proposed and final-rule obligations, matches comments to the obligations they address, and classifies proposed-final outcomes; each load-bearing component is evaluated against blind human judgment. We apply the framework to 70,075 comments across 36 EPA anchor rulemakings, drawn from a corpus of 786,197 comments across 6,145 dockets from 2010-2022. Three descriptive findings emerge. First, engagement is associated with revision at a modest within-docket magnitude. Second, support-versus-opposition direction does not clearly differentiate outcomes, an informative null inconsistent with simple preference-aggregation. Third, under a permissive reconstruction of commenter type, organizational-majority engagement concentrates in editorial-refinement rather than substantive-modification outcomes at the cross-docket level. A blind human audit of the load-bearing outcome contrast preserves this third finding under corrected labels and reveals that text-similarity methods are insufficient for distinguishing editorial from substantive regulatory change, a measurement-validity lesson we treat as a supporting methodological contribution. Together, these findings locate the equity asymmetry upstream of agency response: in differential capacity across commenter populations to identify, interpret, and contest specific legal obligations.

This paper introduces a policy analysis framework for systematic, transparent assessment of AI governance proposals in an evolving and contested regulatory landscape. AI policy debates often collapse into binary positions that obscure underlying tradeoffs and normative assumptions. The framework structures policy analysis around multiple policy attributes, allowing users to surface priorities and tensions without prescribing outcomes. We use a mixed-methods approach that integrates qualitative insights from subject matter experts with computational text analysis to inform the design of policy attribute rubrics. This quantifies the relative emphasis of different policy objectives and presents them through comparative visualizations that support interpretability and cross-policy comparison. The paper also examines the use of commercial LLMs for rubric-based policy analysis, benchmarking their outputs against a domain-trained rubric-calibrated model with explicitly defined analytical assumptions. Rather than assessing policy effectiveness or desirability, the framework focuses on relevance and alignment across attributes. By making analytical assumptions explicit, including attribute selection, rubric construction, and weighting schemes, the framework enables users to evaluate whether its embedded priorities align with the users' own normative commitments. The approach is jurisdiction-agnostic and intended to support policymakers, analysts, and researchers navigating complex AI governance environments. Contributions: (1) multidimensional policy assessment through empirically grounded rubrics that surface tradeoffs rather than resolving them; (2) a transparent hybrid methodology combining feedback from subject-matter experts with computational validation; and (3) use of domain-trained rubric-calibrated models as a benchmark for comparing different general-purpose large language models.

An open-weight LLM can write composition setpoints every five minutes. What a plant still needs is a hard check: named constraints, logged margins, and an admit/block decision before the regulatory layer moves. This paper puts that check in a rule-based forked-twin counterfactual gate (nine pinned constraints) and leaves the regulatory layer unchanged. On Skogestad's Column A the ladder is PID-only (C0), linear MPC (C1), ungated agent (C2), and gated agent (C3) under one contract: identical level closure (M_D, M_B), scenarios, and seeds; C2/C3 share the linear-MPC backend. The split is not subtle. Off-nominal target acquisition: the agent beats Pareto-tuned linear MPC in the strong band (C2/C1 IAE ratio 0.361 at the upper CI). Disturbance rejection on the same 16-point grid inverts by 16.03 at the upper CI (10.18 at the point estimate), where an ungated LLM supervisor does not belong. The gate compresses a specification-abandonment attractor into a bounded offset (d approx. -1.4; P95 cell IAE 11.5 to 0.77). A one-line prompt fix removes the attractor at source (6/10 to 0/10; sensitivity only, not a new headline). In a 250-cell statistical pass, 534 of 590 gate interventions are spec-on-bound geometry: the operating specification sits on a safety limit, so a well-behaved OP becomes inoperable while misbehaving ones are only contained; 318 blocks still correct actively harmful proposals. Headlines are single-column and model-conditional on DeepSeek-V4-Flash. A second-family sweep (NVIDIA Nemotron-3-Super) keeps the disturbance-rejection fails band and plant-side failure geography; magnitudes and protocol operability stay model-conditional, and Super target-acquisition strong cells are survivors only (not confirmation). Transfer means twin, constraint envelope, and setpoint interface, not a second plant class measured here.

The aim of this article is to verify whether integrating large language models (LLMs) with the Retrieval-Augmented Generation (RAG) architecture enables their transformation from standalone generative models into components of cognitive computing infrastructure with enhanced epistemic reliability. The study proposes an architectural approach based on locally deployed LLMs operating in on-premises environments without high-end GPU accelerators and examines their applicability in supporting regulatory management processes requiring continuous analysis and interpretation of legal acts. The proposed solution combines local LLMs with external knowledge repositories, creating a hybrid cognitive architecture in which the language model performs semantic interpretation while the RAG layer provides controlled knowledge retrieval, contextualization, and traceability of information sources. The implementation was validated using the Ollama and LM Studio execution environments together with the Polish language models Bielik and PLLuM running on consumer-class hardware. The results demonstrate that augmenting LLMs with RAG significantly improves the factual consistency, domain specificity and normative precision of generated texts while reducing the risk of unsupported content generation. Furthermore, the study shows that integrating RAG introduces auditability, controlled knowledge management and dynamic updating of regulatory information without retraining the language model. The findings indicate that locally deployed LLMs enhanced with RAG should be regarded not merely as text generation tools but as semantic processing modules within cognitive computing infrastructures supporting regulatory compliance and organizational decision-making in environments characterized by high legal and informational volatility.

Understanding and complying with traffic regulations is a safety-critical requirement for autonomous driving, yet remains challenging due to the diversity and context dependence of traffic signage. Importantly, regulation understanding is not a simple recognition task, but a reasoning problem: whether a rule applies depends on interpreting the sign in relation to the spatial layout of lanes and scene context. To support such reasoning, MapDR provide fine-grained annotations that link each traffic sign's regulatory rules to the specific lanes they govern. Existing methods, however, largely treat this as direct sequence prediction, ignoring the underlying reasoning that connects sign semantics and map structure. To address this limitation, we explicitly incorporate reasoning into this task and propose a framework that equips vision-language models (VLMs) with chain-of-thought (CoT) capabilities. We first design a scalable CoT curation pipeline that bootstraps rationales from a strong LLM through a two-round strategy and employs a VLM-based verifier to filter out incorrect cases, yielding a high-quality set of (CoT, answer) pairs. Building on this foundation, we adopt a two-stage training scheme: supervised fine-tuning (SFT) to teach rationale-to-answer generation, followed by GRPO reinforcement learning with answer-grounded, fine-grained rewards to further improve final answer accuracy. Extensive experiments on MapDR show that our approach significantly improves both interpretability and accuracy, establishing the first reasoning-based framework for regulation-aware autonomous driving.

Predicting cellular responses to unseen chemical perturbations is challenging due to unknown targets and mechanisms, high-dimensional expression responses, and limited experimental coverage of the large small-molecule design space. We propose PerturbPFN, a PFN-style amortized model for unknown-target perturbation prediction under a hierarchical synthetic structural prior. Instead of directly regressing high-dimensional expression responses, PerturbPFN infers a latent system graph, sparse atomic intervention targets, and intervention strengths, then propagates their effects through an SCM decoder. The model is trained entirely on prior-predictive synthetic episodes generated from biologically motivated graph and expression simulators, enabling structured in-context learning without test-time gradient updates. We evaluate PerturbPFN on both real single-cell perturbation data and synthetic benchmarks, covering effect prediction, target identification, and regulatory structure discovery. Our results show that PerturbPFN offers a complementary trade-off to specialized baselines, achieving competitive perturbation prediction with low inference cost while exposing interpretable intermediate estimates of targets, strengths, and system structure.

Regulating activities where regulatees use autonomous and agentic AI is challenging. Regulatory assumptions about regulatee knowledge and control no longer hold true; much of that lies elsewhere in the AI supply chain which thus needs to be brought within the scope of regulation. Governance systems for autonomous AI cannot replicate existing governance models, but need a fresh approach. Retrospective supervisory oversight becomes ineffective as a risk management tool, and AI autonomy generates new systemic risks which require new solutions. This paper investigate four regulatory systems: UK regulation of content platforms, data protection, UK financial services, and the EU AI Act'92s cross-sectoral regime. It analyses the challenges posed by autonomous and agentic AI and proposes potential solutions which regulators might adopt. These will transform regulation from a reactive process to an active one, and assist it in adapting to the challenges of AI autonomy.

Cooperative gene regulation often depends on groups of regulators acting jointly, but most gene regulatory network (GRN) inference methods output pairwise regulator-target rankings. We introduce Bottleneck-Aware Regulator-Set Inference and Diagnosis (BRIDGE), a framework for complete regulator-set recovery, and Targeted Recovery Attribution for Cooperative Evaluation (TRACE), a diagnostic suite that attributes failures to retrieval, set-level scoring, decoding, and evaluation bottlenecks. TRACE includes a leak-free mechanism-mismatch cooperativity stress test in which cooperative targets are generated by random nonlinear mechanisms rather than product interactions. This design avoids feature-mechanism circularity: Residual higher-order set scoring (Residual HOS2) operates on raw expression vectors without handcrafted product-correlation features. Across 30 matched seed-cooperativity settings, Residual HOS2 improves Jaccard similarity from 0.382 to 0.460, recall from 0.522 to 0.597, and exact recovery from 0.053 to 0.113 over a decomposable pairwise set scorer (PairS2), although exact recovery remains low. On SERGIO DS3, oracle retrieval and TRACE show that candidate coverage is necessary but insufficient because set-level misranking remains the dominant source of exact-recovery failure. PairS2 proposal followed by Residual HOS2 reranking reduces HOS2-scored candidate sets by 94-97% while largely preserving exact-recovery behavior. These results distinguish edge ranking, candidate retrieval, set-level scoring, and exact cooperative regulator-set recovery as separate objectives.

Adaptive agents do not always regulate under the same timing conditions. Sometimes stabilization can begin before a disturbance has fully entered the internal state; at other times the agent can only recover after disruption has taken hold. A simple expectation is that an agent moving between these conditions should behave like a weighted average of the two fixed cases: the more time spent in reactive recovery, the greater the regulatory burden. This paper shows that expectation can fail. In a simulated adaptive agent with retained state history, at an operating point where sustained reactive control is more costly than sustained anticipatory control, intermittent access to anticipatory control reduces the mean regulatory burden below the value predicted by a fixed-mode mixture. The effect appears under both periodic and stochastic switching schedules: losing anticipatory access does not simply dilute its benefit, and restoring it intermittently can reorganize the later regulatory burden. High-statistics runs (N = 1000 matched replicates per schedule) resolve a negative nonlinear switching penalty across every tested schedule. The effect is small but consistent: about half a percent of the mean gain, with 63-68% of replicates falling below zero. Late-window diagnostics reveal no unresolved upward accumulation of regulatory burden. The result identifies a design-relevant timing principle. In history-dependent adaptive systems, the burden of remaining organized is not set only by how much time an agent spends in each mode; the order in which disturbance and recovery enter the state can change the subsequent burden. Intermittent anticipatory control may therefore act less like a partial failure of regulation than like a mechanism for reducing the long-term burden of recovery.

Artificial intelligence (AI) is rapidly transforming economies, societies, and polities, raising fundamental questions about how it should be regulated. Policymakers face choices over whether to prioritize innovation or safety, rely on public oversight or private self-regulation, and govern nationally or internationally. Yet little is known about how citizens evaluate these competing priorities. Here we report a conjoint survey experiment conducted in seven countries with diverse political and economic profiles. We find that citizens strongly support regulating AI and generally prioritize safety over innovation, public governance over private self-regulation, and international over national approaches. The preference for safety is strongest among those who perceive AI as risky, unpredictable, and personally consequential. These findings reveal a systematic misalignment between dominant regulatory approaches and citizen preferences.

On-policy distillation (OPD) has become a key paradigm in LLM post-training, yet its training dynamics remain poorly understood. We present a systematic study examining the role, pathologies, and regulations of OPD. We first clarify the role of OPD as an exploration catalyst: it steers the student toward correct reasoning paths via dense token-level guidance, without expanding capability ceiling. We confirm this by showing that prompt diversity matters more than per-problem sampling numbers, and critically, that the effectiveness of OPD hinges entirely on the quality of its guiding signal. This dependency exposes two pathologies that derail exploration. The Student-Teacher Mismatch occurs when a large teacher-student distributional gap causes the guiding signal to misalign with task correctness, steering exploration in counterproductive directions. Length Exploitation arises when the aggregated token-level objective creates length-dependent shortcuts, allowing the student to game the reward landscape through response truncation or redundant padding, exploring degenerate length modes rather than reasoning strategies. To tame these pathologies, we investigate lightweight signal regulations: advantage clipping and log-scale compression, ensuring exploration is guided by faithful signals. Experiments across seven benchmarks demonstrate that these regulations alleviate length exploitation and enable effective distillation, stably surpassing OPD variants and RLVR baselines, thereby confirming that well-regulated signal quality, rather than mere teacher scale, governs successful exploration in OPD.

Tasks such as customs tariff classification, export control categorization, and standards-based equipment coding require assigning an input instance to a fine-grained class under an explicit regulatory hierarchy. Unlike standard text classification, the correct label in these tasks is not determined by semantic similarity alone, but by rule-defined boundaries, threshold conditions, exclusion clauses, definitions, and local exceptions. As a result, two highly similar inputs may require different labels, while a retrieved passage that appears relevant may still be inapplicable under the governing rules. Existing flat classifiers, hierarchical text classification methods, and retrieval-augmented LLM systems are not designed to jointly enforce hierarchical validity, rule consistency, and fine-grained boundary reasoning. In this paper, we formulate this setting as regulation-driven fine-grained hierarchical classification, where an external instance must be assigned to a fine-grained class through a valid path in a regulatory hierarchy and supported by auditable evidence. We construct four benchmark datasets from representative regulation-intensive scenarios and validate the annotations through an expert-in-the-loop process. We further propose a constraint-aware hierarchical search framework that converts regulatory documents into a searchable tree, retrieves only valid local candidate nodes, and uses structured regulatory fields with evidence snippets to guide each next-hop decision. Experiments show that our method achieves the best mean accuracy on all four datasets and provides interpretable decision paths, with the largest gains on cases involving fine-grained neighboring categories and rule-based boundary conditions.

The adoption of non-parametric machine learning models for regulatory capital estimation introduces a fundamental governance challenge: the inability to explain model outputs in a manner auditable by supervisory bodies. This 'black box' problem remains a major barrier to the adoption of Gaussian Process Regression (GPR) and related ML architectures in ICAAP and CCAR workflows despite their predictive advantages over traditional parametric approaches. This paper addresses this barrier through SHARC (SHAP for Regulatory Capital), an explainability framework for the Hybrid GPR-HS architecture and its stress-testing extension. SHapley Additive exPlanations (SHAP), derived from cooperative game theory and satisfying the properties of Local Accuracy, Missingness, Consistency, and Efficiency, are applied to Stressed Value-at-Risk (SVaR) outputs under three macro scenarios: West Asia War, Climate Risk, and AI Bubble/Regulatory Burden. SHARC decomposes SVaR into baseline, mean-driven, and volatility-driven components, enabling transparent linkage between scenario design and capital outcomes. Two findings emerge. First, SHARC consistently links non-linear SVaR outputs to underlying scenario inputs, confirming framework fidelity and providing auditable traceability of capital drivers. Second, under stress conditions, the mean return component (directional loss magnitude) dominates the variance component (volatility baseline) in determining capital levels, with implications for capital limit-setting, position management, and hedging strategy. The results establish SHARC as a regulator-aligned explainability layer that makes the Hybrid GPR-HS framework fully auditable and consistent with FRTB, ICAAP Pillar 2, and CCAR transparency requirements.

Ensuring software compliance with regulations such as the General Data Protection Regulation (GDPR) and the Artificial Intelligence Act (EU AI Act) poses a significant challenge, as requirements engineers must translate complex legal text into actionable software requirements - a process that remains largely manual and error-prone in practice. We present an automated regulation-to-requirements pipeline that identifies requirement-bearing clauses in regulatory documents and derives system-agnostic software requirements, accompanied by plain-language explanations, traceable to their legal sources. We evaluate the pipeline on the full clause sets of the GDPR (398 clauses) and the EU AI Act (574 clauses). For requirement-bearing clause identification, the approach achieves macro-averaged F1 scores of 0.82 and 0.78, respectively, outperforming a SetFit-based baseline. Human evaluation shows high completeness (4.60 and 4.45) and correctness (3.74 and 3.54) of derived requirements, while explanation clarity scores are near-ceiling (4.92 and 4.94) on a 1-5 scale. We implement the approach in Reg2Req, a publicly released tool that further supports requirement classification, use case seeding, cross-reference analysis, definition indexing, and a traceability matrix to operationalize regulatory compliance in practice. A user study with 25 practitioners shows that the plain-language explanations significantly improve comprehension of derived requirements and confidence in acting on them (p < 0.001), and that all participants would use Reg2Req as a starting point for deriving software requirements from a regulation.

Adaptive agents are usually judged by what they do, but an agent can appear stable while the internal effort required to keep it stable is increasing. This hidden regulatory burden matters for artificial agents operating under noise, delay, or changing demands: two systems may reach similar internal states while one requires much more corrective control to get there. Here, we study whether that burden depends on history. Using a computational model of adaptive uncertainty regulation, we drive an artificial agent through a continuous change in its uncertainty target and then reverse the change without resetting the agent. This creates a simple test for carryover: does the controller respond only to the current target, or does the path by which the agent reached that target still matter? The simulations show a clear history-dependent effect. The adaptive gain required to regulate the agent forms a reproducible hysteresis loop, meaning that the same target can require different levels of control depending on whether the agent is moving toward or returning from a more demanding regime. The timing of regulation also matters. When stabilization is available before disturbance exposure, the agent generally requires less adaptive gain than when it can only recover after disturbance has already acted. The state-level coherence measure also shows path dependence, but the timing effect is much clearer in regulatory gain. The main difference is therefore not that anticipatory regulation produces a completely different state. Rather, it reaches comparable regulated behavior with lower modeled control demand. These results suggest that adaptive agents should be evaluated not only by whether they remain organized, but by how much regulation they must recruit to do so.

Recent literature shows that large language models (LLMs) are useful for general-purpose tasks yet perform poorly on specific domain ones. One reason is the difficulty of supplying narrow context to a general-purpose model and of bounding the task it is asked to perform. It is possible to hypothesise that a multi-agent reformulation under process-control principles offers a route to address those points, since control theory provides a discipline of decomposing a system into elements of contained scope, each defending one controlled variable, with conflicts resolved by structural priority: MIN/MAX selector networks for CV-CV switching and split-range (split-parallel) logic for MV-MV switching. The present work proposes such a reformulation, derived from Advanced Regulatory Control (ARC) theory. Each feedback loop in the ARC chain is mapped to one specialised LLM operator agent carrying the loop's control-theoretic context (controlled variable, setpoint, chain priority, selector kind). The chain's interaction logic (MIN/MAX selectors, override paths) is encapsulated as a single orchestrator agent. Two orchestrator variants are tested: a deterministic rule chain, and a Claude-based LLM orchestrator at a slower tier. The control principles limit each agent's task and inform how its limitations are handled. The multi-agent system inherits the safety property of the ARC chain: every constraint conflict is resolved deterministically by the orchestrator, regardless of the LLM output. Evaluated on a dairy-barn ventilation case over a 4-day mixed-season scenario, Qwen 2.5 7B Instruct operator agents running offline on a 24 GB consumer GPU at a 5-minute cadence produce auditable trajectories, each paired with an operator-voice rationale that supports a control campaign logbook.

Reviewing nuclear regulatory documents requires multi-hop reasoning across tens of thousands of pages, where judgments depend on evidence assembled across multiple chapters. We frame this task as planning: an LLM-based agent observes the evidence collected so far, picks the next document fragment to inspect, and stops when the evidence is sufficient. The agent operates over a vectorless document tree using browse, read, and search tools, and maintains a dynamic knowledge graph (KG) as state. On a 200-question benchmark over NuScale Final Safety Analysis Report (FSAR) documents, the system reaches 81.5% accuracy with a RAGAS Faithfulness of 0.93. The dominant performance factor is planning: against PageIndex, which uses the same document tree without state-conditioned action selection, the gap is +38.0pp (43.5% to 81.5%, p<0.001). The system also outperforms LightRAG (73.0%, p<0.05), HippoRAG (70.5%, p<0.01), and GraphRAG (49.5%, p<0.001), and matches RAPTOR (75.5%, p=0.11) without offline indexing. Edge inference adds 2.8x cost without raising accuracy; we retain it as a traceability module. Of 7,391 inferred edges, 3 Violates edges (0.04%) flag scope boundaries (Q058) and partial conformance (Q176) as typed annotations that a human reviewer can audit.

We introduce the process harness, a new mechanism for uplifting legacy workflows into Agentic Business Process Management (Agentic BPM) without replacing the underlying workflow engine. A process harness places a policy-governed agentic layer around a deterministic workflow engine, intercepting designated control points to contribute reasoning, adaptation, and oversight while the engine retains structural authority over the process. To define the process harness rigorously, we develop the Task-Decision-Flow (TDF) model, specifying both its data schema and its execution semantics. TDF decomposes LLM reasoning across three policy-governed agent types: a TaskAgent for knowledge-intensive task execution, a DecisionAgent for per-case gateway routing, and a FlowAgent that governs runtime flow adaptation through a principled hook mechanism. Each agent reasons within an explicit policy drawn from the process FRAME, the aggregate policy set governing all LLM calls in the system. We then present CUGA FLO as the design and implementation realization of the TDF model, and demonstrate it on a loan approval workflow that exercises all three agent types and hook-driven regulatory override. The process harness uniquely reconciles imperative requirements, realized through deterministic workflow execution that enforces structural compliance, with normative requirements, realized through policy-framed agentic autonomy invoked at designated control points wherever the process demands it.

Medical device recalls are a critical regulatory mechanism for protecting patient safety. The growing volume of FDA recall records presents challenges in post-report recall triage, severity assessment, and root-cause interpretation. Existing studies mostly address recall occurrence prediction or root-cause analysis separately, while joint modeling of recall severity and root-cause categories has received limited attention. We develop an automated recall triage framework using 54,165 FDA medical device recall records from openFDA, covering the period from 2002 to October 2025. We first evaluate classical machine learning and boosting-based models for recall severity and root-cause category prediction. We then develop RecallRisk-BERT, a multi-task model that combines PubMedBERT-based textual representations of recall narratives with embedding-based representations of structured categorical features, including product code, regulation number, and medical specialty. The model simultaneously predicts recall severity (Class I/II/III) and a consolidated root-cause category (9 classes). Performance was evaluated using accuracy, macro-averaged precision, recall, F1-score, and ROC-AUC. In single-task severity prediction, our LightGBM-based text--tabular configuration achieved the strongest performance, with an accuracy of 0.963, macro-F1 of 0.856, and ROC-AUC of 0.974. In the multi-task setting, RecallRisk-BERT substantially outperformed the single-task PubMedBERT baseline. Model-derived risk rankings were strongly consistent with observed root-cause severity patterns (rho = 0.983, p = 1.936e-6). These findings indicate that text--tabular learning can support scalable post-report recall triage, regulatory decision support, and model-based root-cause risk analysis.

Progress in legal AI increasingly depends on access to authoritative legal text at scale. Yet one of the most consequential layers of American law remains largely absent from existing machine-readable corpora: local ordinances. Local codes govern zoning, housing, business licensing, public health, noise, animal control, and many other domains of everyday regulation, but they are fragmented across vendor platforms designed for human browsing rather than bulk research access. We introduce LOCUS - the Local Ordinance Corpus for the United States - a comprehensive corpus and county-harmonized access layer for U.S. municipal and county ordinance codes. The raw corpus, available for release to researchers, represents nearly all publicly available municipal and county ordinance codes. The resulting raw corpus contains codes from 9,239 cities and counties. A smaller county-harmonized LOCUS access layer provides coverage for the largest 2,309 of 3,144 U.S. counties, accounting for a majority of the population. We use OCR to handle the myriad of document formats that have kept the law from being a public resource. We release the corpus with coverage metadata to support reproducibility, downstream legal AI research, and the incremental expansion of machine-readable access to local law. We train a collection of ModernBERT-based classifiers and scorers to facilitate analyzing U.S. local law among several dimensions, such as opacity and paternalism, that have not previously been studied at this scale. LOCUS-v1 and its derivative models are available at: https://huggingface.co/datasets/LocalLaws/LOCUS-v1

Multi-fuel compression-ignition engines offer fuel flexibility but introduce uncertain, time-varying fuel reactivity, represented by cetane number (CN), which complicates cycle-to-cycle combustion-phasing control. This work formulates CA50 regulation under latent CN variation as a partially observable sequential decision problem and systematically evaluates controllers with increasing temporal and representational capacity, including LinUCB, history-augmented contextual bandits, observation-only DDPG, recurrent DDPG, and a proposed GRU-guided RL framework. A Gaussian-process surrogate trained on experimental multi-fuel engine data provides a controlled and reproducible evaluation environment. Results show that myopic and fixed-history bandit methods degrade under CN variation, observation-only RL suffers from latent-state aliasing, and generic recurrence is insufficient when CN evolves rapidly. The proposed framework learns a compact GRU-based representation of fuel reactivity from combustion history and conditions both actor and critic on this estimated signal rather than oracle CN. By training the policy on the same imperfect fuel-reactivity information available at deployment, the controller avoids train-deploy inconsistency in conventional online estimate-then-control pipelines. Across unseen CN trajectories, the policy achieves stable CA50 regulation with mean absolute tracking error below 0.25° CA at the training setpoint, while producing smooth, physically consistent SOI and glow-plug-power actuation. These results show that combustion control under latent, continuously evolving fuel dynamics requires more than standalone estimation or generic recurrence. By aligning fuel-reactivity inference with control policy learning, the proposed framework enables reactivity-aware decision-making using the same estimated state available during deployment.

Policy-oriented agent-based models are increasingly used to study regulatory interventions in complex adaptive socio-technical systems. Recent adaptive ABM frameworks distinguish between static and adaptive agents, fixed and adaptive policies, and alternative controller designs. However, most diagnostic workflows remain ex post: trajectories are analysed after simulation, but the resulting evidence is not systematically fed back into the policy controller. This paper proposes a lightweight machine-coached policy-revision layer for adaptive agent-based regulation. The layer represents policy decisions as defeasible rules with explicit conflicts and priorities, generates explanations for controller actions, and allows diagnostic failures to be translated into rule additions, removals, or priority changes. The contribution is not a new optimal controller and does not claim formal guarantees for unrestricted machine coaching. Instead, it provides a simulation-compatible operationalization of controller-level contestability: policy decisions can be explained, challenged, revised, and re-evaluated in held-out simulation runs. A stylized emissions-regulation ABM is used as the experimental component. A controlled simulation experiment focuses on an over-conservatism failure in the VPVA regime. The predefined coaching template adds a relaxation rule to the symbolic controller, reducing over-conservatism recurrence under held-out seeds while preserving violation, overshoot, and volatility guardrails. The paper argues that machine coaching is best understood as a controller-level extension of explainable adaptive ABM, complementary to causal, information-theoretic, and trajectory-based diagnostics.

Policy models often assume that the relationship between a policy instrument and its outcome remains stable across institutional conditions. In adaptive socio-technical systems this assumption may fail: regulatory change can alter incentives, agents can respond strategically, and the mapping from policy variables to aggregate outcomes can change. This paper studies such regime change as a transfer-learning problem in adaptive multi-agent systems. A policy regime is represented as a learning problem induced by an observable input distribution and a target function mapping policy variables to outcomes. We compare a blank-slate learner that searches a flexible hypothesis class in the new regime with a transfer learner whose effective hypothesis class is restricted by structural knowledge from the previous regime. Transfer is beneficial when this restriction preserves the new target function while reducing effective complexity; it is harmful when the restriction excludes the new target and creates misspecification. A stylized emissions-regulation experimental environment and a dynamic ABM robustness experiment support the claim. When the target regime preserves an affine monotone tax-emissions relation, transfer improves empirical small-sample performance. When the target regime introduces a threshold break, the same transferred structure produces negative transfer: held-out error remains high, online prediction generates more mistakes, and repeated online streams show larger cumulative and final-window error under misspecification. The contribution is methodological: previous regulatory experience should be reused when it captures stable structural invariants, but treated cautiously when policy change alters the policy-outcome relationship.

Agent-based models are widely used to evaluate policy interventions in complex socio-technical systems, yet many policy-oriented ABMs represent regulation as a fixed scenario parameter. This limits their ability to distinguish whether regulatory conclusions depend on agent adaptation, policy adaptation, or the interaction between both. Building on a previously proposed four-regime architecture, this paper contributes a controlled simulation benchmark rather than a new general framework. Using a single configurable emissions-regulation ABM, we compare constant policy/constant agents, constant policy/adaptive agents, adaptive policy/constant agents, and adaptive policy/adaptive agents under matched simulation conditions. We evaluate naive fixed policies, tracking-aware calibrated fixed policies, and three adaptive controllers: setpoint, safety-margin, and one-sided control. The benchmark recovers expected controller archetypes: setpoint control tracks the cap but produces frequent boundary crossings, safety-margin control reduces violations through conservatism, and one-sided control can limit violations but may ratchet toward over-conservatism when combined with adaptive agents. The contribution is methodological: scalar indicators, cap-relative symbolic diagnostics, trajectory motifs, and visual inspection jointly reveal how regulatory conclusions can differ even when average outcomes appear similar. Adaptive policy-oriented ABMs should therefore be evaluated through regime distinguishability, not only through average performance.

Large Language Models (LLMs) are increasingly deployed in healthcare settings, yet their tendency to hallucinate poses risks when clinical decisions are involved. This study examine whether LLMs recommend recently banned or withdrawn pharmaceuticals when answering clinical questions and tests an agent-based method for reducing such errors. We developed a five-agent "Trust but Verify" system using a single LLM backbone. To measure regulatory knowledge obsolescence, we created an adversarial dataset of 103 clinical MCQs where historically correct answers now refer to banned substances. This scale ensures statistical significance across various therapeutic classes. We evaluated three open-access model families (GPT-OSS, Llama-3, Falcon-3) under vanilla and agentic conditions. Performance was measured via pointwise score, label accuracy, Hallucination Error Rate (HER), and Component Fidelity (CF) score. We also observed clinical safety regression in proprietary models. In default configurations, all models showed high hallucination rates, consistently selecting banned drugs that matched training data patterns. Our proposed agentic architecture reduced HER by approximately 53% across models. Pointwise scores shifted from -0.25 (unsafe recommendation) toward 0.0 (appropriate refusal). The safety audit intercepted dangerous outputs even when models' parametric knowledge favored the banned substance. The proposed multi-agent framework offers a model-agnostic method for enforcing regulatory compliance that prioritizes patient safety over fluent text generation. Our work demonstrates a practical approach for deploying autonomous AI systems in safety-critical healthcare settings. It shows how real-time regulatory data can be integrated into LLM pipelines to support clinical decision-making.

Predicting cellular transcriptional responses to genetic perturbations is a central problem in single-cell biology, especially in the zero-shot setting where the perturbed gene or gene combination is unseen during training. A major difficulty is that perturbation effects are not determined by expression state alone: they depend on how the perturbed gene product influences other genes and proteins, how those downstream factors act on cis-regulatory elements, and which regulatory programs are active in the current cell state. To better capture this biological complexity, we propose CisTransCell, a cell-conditioned multi-modal framework for single-cell perturbation prediction that augments each gene with two complementary priors: a regulatory-sequence prior that captures how the gene is controlled, and a coding-sequence prior that captures what the gene product does. By integrating these priors with cellular expression state, CisTransCell models perturbation response as a cascade from gene function to regulatory control to downstream transcriptional change. Experiments on benchmark single-cell perturbation datasets show that CisTransCell achieves strong performance in zero-shot perturbation prediction.

The European AI Act is the first comprehensive regulation of artificial intelligence (AI), setting out extensive obligations, particularly for so-called high-risk and general-purpose AI systems. A key distinguishing feature of AI systems under the AI Act is the capability to infer. Since the AI Act does not clearly define what inference is, there is a gray area for certain data-driven systems. A specific example is credit scoring systems, which are listed by Annex III of the AI Act. At the same time, however, these are often implemented using statistical models for which it is unclear whether they have the capability to infer and thus fall under the AI definition of the AI Act at all. Motivated by statistical learning theory, this work develops a framework for grading different levels of the capability to infer. Based on the AI Act and the Commission Guidelines on the definition of an artificial intelligence system, we analyze which levels constitute sufficient capability to infer within the meaning of the AI Act and where further regulatory clarity is needed. We illustrate the framework by creating two realistic credit scoring workflows and show whether and where inference occurs in them. Our analysis illustrates that not only individual models but the entire data processing workflow must be considered. It also shows that the involvement of human experts during development can have significant influence on the capability to infer. Code can be found at https://github.com/fraunhofer-iais/inference-framework-creditscorecards.

Accurate loss reserving is foundational to insurer solvency, yet accelerating climate driven catastrophes systematically violate the stability assumptions on which traditional actuarial methods depend. This white paper presents a research program testing whether Long Short Term Memory (LSTM) neural networks can detect and adapt to these structural breaks faster and more accurately than Chain Ladder, Bornhuetter Ferguson, and Cape Cod methods. Using 15 plus years of regulatory development triangle data from Florida and Louisiana, enriched with NOAA hurricane intensity indices and sea surface temperatures, we hypothesize a targeted improvement of 15, 20% in reserve accuracy for catastrophe exposed years, a threshold grounded both in the prior neural network reserving literature and in the formal convergence results developed here. Beyond empirical validation, we develop a theoretical framework grounding LSTM structural break detection in probabilistic terms, providing formal performance guarantees that compensate for the limited number of catastrophe events in the test period. We document the research design, methodology, expected contributions, and a candid assessment of limitations.

Motivation: Transformer-based models are increasingly applied to large-scale single-cell transcriptomics, showing strong performance through self-supervised learning on millions of cells. However, most existing approaches treat genes as independent features, and largely ignore prior biological knowledge, which limits interpretability and robustness. In this paper, we explore whether explicitly incorporating gene regulatory information can improve both model performance and biological insight. Results: We present scTransformer, the first Transformer-based approach that builds a priori knowledge of biological mechanisms into the model's attention patterns. By constraining information flow according to known regulatory structures, the model learns representations that are more biologically meaningful. We evaluate scTransformer on a disease-relevant single-nucleus RNA-seq dataset using supervised cell-type classification. Compared to standard Transformers, our approach improves classification accuracy, enhances separation of cell types in embedding space, and produces attention patterns consistent with known regulatory programs. Overall, our results demonstrate that embedding biological structure into Transformer models can enhance interpretability without sacrificing performance, offering a principled step toward biologically grounded foundation models for single-cell omics.

DNA cis-regulatory elements (CREs) such as enhancers control gene expression levels. Accurately predicting regulatory activity from DNA sequences is valuable but challenging, as it requires understanding complex biological regulatory processes. Existing methods typically regress activity scores from sequences in a black-box manner, limiting both interpretability and regression performance. Meanwhile, large language models (LLMs) benefit from explicit reasoning processes, yet directly applying LLMs to raw DNA sequences performs poorly. In this paper, we bridge this gap by introducing R3LM, a framework that teaches LLMs reasoning-informed regression on regulatory DNA through structured biological knowledge. Specifically, we design a biologically grounded data format that structures DNA's regulatory information for improved LLM understanding, and construct CRE-ReasonBench, the first dataset that associates DNA sequences and activity scores with mechanistic reasoning traces. Through two-stage training that first teaches LLMs reasoning over structured biological information then performs regression, R3LM achieves state-of-the-art performance on enhancer prediction across three cell types, outperforming both LLMs with raw sequence input and specialized DNA models while providing interpretable mechanistic explanations. We expect R3LM as an interpretable reward model that can effectively assist biologists in CRE design. Code is available at https://github.com/DuanYi516/R3LM.

Linking FDA-approved medical devices to their underlying United States Patent and Trademark Office (USPTO) patents enables critical applications such as recall root-cause analysis, M&A-driven IP discovery, and technology trajectory mapping. However, this cross-domain entity linking task remains unexplored due to severe semantic gaps: FDA documents focus on clinical outcomes, while patents describe technical mechanisms, yielding minimal lexical overlap. We formalize medical device-patent linking as a challenging cross-domain entity linking problem characterized by label scarcity and domain shifts. Using cardiovascular devices as a high-impact, representative domain featuring diverse technologies, high recall rates, and abundant disclosures, we construct a benchmark with 434 devices, 698K patents, and 585 high-fidelity expert-verified pairs. To address these challenges, we propose Bridge-MedDevKG, a coarse-to-fine framework that integrates (1) MedDevOnto, a domain-specific ontology that anchors device concepts via three-tier UMLS normalization; (2) Multi-signal candidate generation fusing company affiliation, semantic similarity, and ontology-weighted entity overlap; and (3) Heterogeneous reranking with multi-signal scoring and XGBoost classification on hard negatives. Our approach achieves a conservative lower-bound recall of 91.6% on the gold standard with 50.9% noise reduction, substantially outperforming LLM baselines under comparable evaluation. The resulting MedDevKG provides 6.8M high-confidence links, laying a scalable foundation for regulatory-IP integration across medical specialties.

Regulatory review of advanced nuclear reactor designs routinely spans more than three years and consumes hundreds of millions of dollars in combined regulator and applicant labor. We present the Regulatory Context Protocol (RCP), an Agent-to-Agent communication standard that replaces the formal human-to-human pipeline between regulators and applicants with a structured, auditable agentic channel, while preserving human oversight at safety-significant decision points. The protocol is calibrated against an analysis of 1,236 documents from U.S. Nuclear Regulatory Commission advanced reactor dockets and demonstrated with a working multi-agent pilot. Against an 89M USD, 42-month Reconstructed Baseline, RCP cuts costs by 50-77 percent (21M-44M USD) and timelines by 65 percent (15 months). Without a shared protocol, Standalone Agents reach only 54M-74M USD and 21 months. The residual cost-and-time gap is structural, not algorithmic: it traces to the inter-organizational pipeline that only an agent-to-agent standard can compress. The same bottleneck - formal multi-party review under strict auditability requirements - characterizes pharmaceutical approvals, environmental permitting, financial supervision, and aviation certification. The US regulatory paperwork burden carries a 426.5 billion USD annual opportunity cost; replicated broadly, the projected 50-77 percent reduction implies savings on the order of 210-330 billion USD per year - approaching 1 percent of US GDP.

High-grade gliomas integrate into neural circuits through functional synapses with neurons, raising the question of which noncoding elements shape synaptogenic gene expression in tumor cells. The regulatory program written across the dark genome, what we call the $\textit{dark regulome}$, is the natural substrate to probe, and sequence foundation models offer a zero-shot route through in-silico mutagenesis (ISM); yet likelihood-based scoring is tautologically coupled to local sequence predictability, leaving the regulatory interpretation underdetermined. Across three architecturally distinct foundation models (Caduceus-Ph, HyenaDNA, Enformer) and 30,448 dark genome elements at 92 glioma-relevant loci, we introduce a residualization-and-permutation diagnostic that separates predictability-driven from regulation-driven RIS variance. A sharp 10kb proximal-regulatory horizon survives every control we apply, but the LM-derived element-class hierarchy does not: a six-feature linear baseline matches Caduceus top-decile membership at AUC $= 0.985$. Cross-architecture decomposition cleanly separates a sequence-predictability layer (the two language models co-rank long well-predicted transposable elements) from a regulatory-output layer (Enformer alone retains residual cCRE-discriminative signal), with literally zero overlap between the two top-100 lists. Conservation, brain cis-eQTL, and STRING-PPI cross-checks then anchor what biology survives: top-100 elements across all three models are $3.3\times$ enriched per model for matching brain eQTLs ($p_\mathrm{emp} < 5\times 10^{-3}$), while a tempting transposable-element regulatory layer and a striking NRXN1+NLGN1 protein-pair convergence both fail proper permutation tests once those tests are constructed. We deliver the diagnostic as a general methodological tool for any ISM-based regulatory study.

Veterinary pharmacovigilance systems are essential for monitoring adverse drug events (ADEs), yet existing approaches often fail to capture region-specific toxicity patterns shaped by local biological and regulatory contexts. In Japan, these challenges are amplified by species-specific metabolic differences and reporting practices defined by the Ministry of Agriculture, Forestry, and Fisheries (MAFF). Most prior work relies on prediction-oriented models, limiting mechanistic interpretability. This study proposes a regulatory-integrated unsupervised framework for pattern discovery using the National Veterinary Assay Laboratory (NVAL) database. ADEs are encoded into organ system-aligned representations and adjusted for species-specific reporting biases, enabling cross-species comparison. Similarity-based clustering and dimensionality reduction are applied to identify latent toxicity structures. Analysis of 4,120 high-confidence ADE reports (9,080 drug-ADE combinations) identified three significant species clusters (p < 0.01), including hepatic-dominant patterns in companion animals (0.42 $\pm$ 0.06), renal toxicity in ruminants (0.39 $\pm$ 0.07), and dermatological sensitivity in sheep (0.35 $\pm$ 0.07). Drug-level clustering achieved 83% alignment with pharmacological classes, while cosine similarity outperformed alternative metrics (silhouette score: 0.48; cluster precision: 87%). Regulatory validation showed strong agreement with established classifications. These findings demonstrate that regulation-aligned unsupervised analysis can uncover biologically meaningful, region-specific toxicity patterns, providing an interpretable and scalable framework for veterinary drug safety assessment.

Patient safety event triage, determining whether a clinical event is reportable under jurisdiction-specific policy, is a high-stakes task typically performed manually by patient safety experts. Although LLMs may support this workflow, reliable evaluation is limited by the lack of benchmarks to capture evidence-grounded policy reasoning, proactive information seeking for incomplete reports, and principled abstention in irreducibly ambiguous cases. We address this gap with a policy-grounded construction methodology centered on the clause card, a structured representation that factorizes regulatory text into auditable decision specifications. Combining clause cards with anchor-driven instantiation and closed-loop verification, our scalable pipeline produces narratives with by-construction ground truth and naturally supports generating missing information and uncertain variants. We instantiate this method on Minnesota's 29 Reportable Adverse Health Events, producing PSEBench, a 5,074-case benchmark with an agentic evaluation environment. Evaluation on 15 representative LLMs reveals consistent capability trends, demonstrates the benchmark's utility, and identifies actionable gaps toward reliable LLM-based patient safety event triage.

Reinforcement learning (RL) has become a dominant post-training paradigm, enabling large language models (LLMs) to learn from rewards. We observe that societal regulations are structurally similar to reward functions. They define measurable outcomes, thresholds, and exceptions, while often leaving institutional intent only partially specified. We hypothesise that the RL training process may exploit these gaps and therefore ask whether models' well-known tendency to hack reward functions during RL can scale into a more consequential failure mode named societal hacking: discovering loopholes in the rules society runs on. To study this phenomenon, we introduce SocioHack, a sandbox of 72 societal environments, and find that within these environments, reward hacking naturally emerges and leads to regulatory loophole discovery. Models learn to hack the social rules and generate strategies that remain technically compliant while defeating regulatory intent, and current LLM safeguards provide only limited mitigation. Therefore, collecting in-the-wild feedback for model training requires greater caution, and we need a next-generation post-training paradigm for safely iterating LLMs in real society.=

User Experience Research (UXR) in a legal and regulatory contexts presents unique challenges that require specialised approaches to protect vulnerable populations whilst generating actionable insights. Digital consultation, appointment booking, and medication delivery platforms show promise for extending care access; however, their real-world effectiveness is curtailed by an absence of theoretically grounded user experience research (UXR) methodologies that adequately account for the psychosocial conditions of these populations. This paper introduces a Generative AI-augmented UXR methodology, grounded in the UXR Point of View (PoV) Playbook, to guide the design of psychologically safe, low-cognitive-load digital health interventions for MSM and transgender individuals living with HIV/AIDS in Nigeria. Drawing from empirical research involving co-design workshops, thematic analysis, and requirements engineering, the methodology is operationalised through a four-stage UXR process encompassing AI-supported hypothesis generation, foundational planning, insight generation via Building Blocks, and the construction of stakeholder-specific PoV narratives. This process results in ten theory-informed UXR Play Cards that translate psychological mechanisms and empirical findings into actionable design guidance. Each play contains actionable tasks, AI-augmented approaches, and ethical guardrails tailored for research with marginalised populations. The output is a set of ten theory-informed UXR Play Cards translating psychological insight and empirical evidence into actionable design guidance. The core contribution is a replicable, stigma-aware, and privacy-centred framework for responsible GenAI use in UXR practice, advancing human-centred digital health design for marginalised communities.

Public consultations generate large volumes of data in the form of stakeholder submissions that are practically unfeasible to analyse manually. We present an end-to-end LLM-based pipeline and interactive dashboard for structured topic extraction from regulatory consultation submissions, demonstrated on the European Commission's Digital Fairness Act (DFA) public call for evidence as a case study. The system processes raw PDF attachments and web-form responses, extracts topic annotations, and grounds every extraction in a verbatim quote from the source text. Applied to 4,322 DFA submissions, the pipeline produced 15,368 topic annotations supported by 20,951 verbatim evidence quotes. Three principles govern the proposed design: verbatim grounding, full traceability, and transparency by design. The dashboard exposes the full extraction dataset through five analytical views, from dataset-level topic overviews to individual paragraph drill-downs, with every result traceable to its source. Beyond the predefined DFA topic categories, the pipeline generated certain stakeholder concerns, such as Age Verification, Payment Processor Censorship, and Digital Ownership, that a fixed-taxonomy approach would have missed. The pipeline is domain-generic; adapting it to a new consultation requires only a prompt update and a new dataset. A live demo is available at https://dfa-dashboard.thalesbertaglia.com/. The code and processed data are publicly available at https://github.com/thalesbertaglia/dfa-dashboard.

As large language models (LLMs) are increasingly deployed in financial services, a single non-compliant interaction can expose institutions to regulatory penalties and direct consumer harm. Existing guard models are built around general harm taxonomies and overlook violations grounded in specific financial regulations. We address this gap with a regulation-driven pipeline that operates directly on regulatory documents, inducing a financial compliance risk taxonomy and synthesizing grounded training data without any predefined violation categories. Instantiating the pipeline on Chinese financial regulations, we release \textbf{FinGuard-Bench}, to our knowledge the first benchmark for financial regulatory compliance detection, with expert-annotated labels at both the query and response levels. We further train \textbf{FinGuard}, a financial compliance detection model built on Qwen3-8B and trained on the regulation-grounded data via supervised fine-tuning and self-play reinforcement learning. On FinGuard-Bench, FinGuard substantially outperforms all baselines, including dedicated guard models and much larger general-purpose LLMs such as Qwen3.5-397B-A17B and GPT-5.1. Furthermore, FinGuard also preserves general safety capabilities and adapts to unseen institution-specific policies using policy documents alone. We will publicly release the code, prompts, and resources used in this work on GitHub.

An Initial Public Offering (IPO) filing is a document released when a private firm goes public, allowing individual (retail) investors to purchase its shares. These filings describe a firm's business, financials, and risks and are long, multimodal documents with narrative text and images. Despite their importance to financial markets, there is no large-scale, standardized dataset or benchmark for studying IPO filings with modern language and multimodal models. These documents pose significant challenges: filings frequently exceed 500,000 tokens and lack consistent structural organization. We introduce the IPO-Toolkit, an open-source framework for downloading and parsing IPO filings into standardized section-structured text and extracted images. The toolkit segments filings, extracts embedded images, and produces structured outputs that enable large-scale, reproducible analysis workflows over long, multimodal documents. Using this infrastructure, we construct the IPO-Dataset, a large, section-structured, multimodal dataset covering more than 109,000 IPO filings and amendments from 1994 to 2026 and containing over 76,000 images. We establish structured evaluation tasks over extracted financial charts, including chart quality and misleadingness assessment. Our experiments show that state-of-the-art multimodal models often diverge from expert human judgments on these tasks, exposing alignment challenges in multimodal reasoning over long, real-world regulatory documents. Beyond benchmarking, the IPO-Dataset enables large-scale analysis of section-level textual variation and cross-industry differences in visual and textual disclosure practices. Our code, dataset, and website are publicly available under CC-BY-4.0.

Deep research agents face vast, interdependent, and pervasively uncertain information. Existing systems explore what evolving intermediate representations should look like, but leave their evolution to the LLM's implicit reasoning. Without explicit regulation, the intermediate layer is easily contaminated by mixed-quality information, and errors propagate along its dependencies, so model scale often ends up substituting for absent regulation. We argue that an agent's mental model should instead evolve through explicit feedback that continuously aligns task understanding with reality, and identify three regulatory loops: interpretive update, deviation feedback, and schema revision. We realise this in VeriTrace, a cognitive-graph framework that explicitly implements the three loops. Using matched Qwen3.5-27B backbones, VeriTrace improves over the strongest matched baseline by an average of 4.82 pp on DeepResearch Bench (DRB) Insight (1.83 pp Overall) and by 5.9 pp Overall win rate on DeepConsult. With Config-DeepSeek, it achieves the strongest reproducible open-source result on DRB.

This paper introduces the Governance Inversion Hypothesis (GIH) to explain a growing paradox in artificial intelligence (AI) governance: under conditions of increasing regulatory expansion and technological complexity, organisations may become more formally governed while simultaneously experiencing a decline in operational control over AI systems. Existing AI governance frameworks generally assume that stronger regulation improves accountability, oversight, and organisational control. This paper challenges that assumption by arguing that governance formalisation itself may contribute to the erosion of control in AI-intensive environments. Drawing on institutional theory, organisational governance research, accountability scholarship, and emerging AI governance literature, the paper develops a conceptual framework explaining how regulatory expansion may weaken operational authority through four interconnected mechanisms: authority fragmentation, symbolic governance expansion, externalisation of control, and authority paralysis. As governance systems become increasingly layered and procedurally dense, organisations may struggle to maintain coherent authority, technical visibility, escalation capability, and meaningful intervention power over opaque and externally mediated AI infrastructures. The paper extends institutional decoupling theory by introducing governance inversion as a structural condition in which governance expansion may actively undermine operational coherence rather than strengthen it. It concludes that the central risk in AI governance may not be the absence of governance structures, but the emergence of institutions that appear increasingly governed while progressively losing the capacity to govern effectively.

Recent RL methods have substantially improved the reasoning abilities of LLMs. Existing reward designs mainly follow two paradigms: (1) Reinforcement learning with verifiable rewards (RLVR) derives outcome signals from executable checks or ground-truth answers, but provides limited guidance for intermediate reasoning behaviors. (2) Rubrics-as-reward (RaR) goes beyond final-answer checking by using natural-language rubrics to assess reasoning quality and task compliance, but often requires instance-specific rubrics and substantial design effort. To address these issues, we introduce Metacognition-as-Reward (MaR), a metacognition-inspired RL framework that guides LLM reasoning through two general process dimensions: i) metacognitive knowledge, which identifies task-relevant information without hand-crafted instance-specific rubrics, and ii) metacognitive regulation, which plans and adjusts the reasoning process to provide reward guidance beyond final-answer outcomes. MaR scaffolds model rollouts into explicit metacognitive components and optimizes them with a trajectory-level reward over task knowledge coverage, regulation fidelity, and final-answer correctness. In this way, MaR extends reward feedback to reasoning trajectories while grounding the reward signals in general metacognitive dimensions. Experiments on 22 benchmarks show that MaR consistently improves model performance, achieving up to a 7.7% gain over the base model and up to an 11.0% gain over vanilla DAPO. Notably, Qwen3.5-9B + MaR narrows the gap to frontier models, surpassing GPT-OSS-120B on overall average and outperforming stronger models on several individual benchmarks. Process-level analysis further shows substantial improvements in reasoning process quality. MaR also generalizes to out-of-domain datasets, where MaR-trained models improve over their corresponding base models on average.

Adverse Outcome Pathways (AOP) are logic models that causally link biological mechanisms that can be measured in a lab to adverse outcomes, relevant to chemical regulatory endpoints. AOPs contextualize new approach methodologies (NAMs), in vitro and in silico methods used as alternatives to animal testing and the sequential events in an AOP serve as multi-scale models spanning biological scales. The AOP-Wiki serves as the global repository for AOPs. While the AOP-Wiki has played a central role in AOP expansion over the past decade, constraints within the current data model and application infrastructure limit the AOP-Wiki from supporting continued AOP growth and evolution. Yet, the transformative power of agentic AI has re-invigorated AOP-Wiki data modernization efforts at a time when core AOP principles can be harnessed to inform use of AI for aggregating and structuring AOP-relevant information. Seizing upon this momentum, we present AOP-Wiki EMOD 3.0, the third in a series of evidence model prototypes, which concretely demonstrates data model expansions and our vision for how the AOP-Wiki might be transformed to better serve regulatory science and emergent use of AOPs in biomedical and One Health contexts. We aim to lay a foundation to support computationally-generated AOPs and quantitative AOPs (qAOPs) by focussing on solutions for AOP-Wiki internal quality improvement, evidence structuring to enhance AOP FAIRness and AI-readiness, and improved integration between the AOP framework and NAMs to better serve next generation risk assessment.

Any system that models the world under finite representational capacity must compress; any compression entails a prior; and the prior is the system's bias. What has not been established is whether uncertainty participates in the dynamics governing future behavior, or merely describes the output distribution without consequence. We introduce a structural distinction between descriptive uncertainty, which does not recursively modulate the system's policy, and regulatory uncertainty, which directly enters the optimization landscape and drives persistent adaptive restructuring. We prove formally that current transformer architectures are confined to descriptive uncertainty at inference. We ground this in thermodynamics via Landauer's principle: for uncertainty to be regulatory, epistemic error must cost real energy; in a decoupled system, hallucinations and correct derivations dissipate identical energy. We test this empirically across three locally-deployed language models (3B, 8B, 70B parameters). Token-level Shannon entropy is statistically invariant across tasks spanning pattern retrieval, causal operator application, and out-of-distribution causal generalization in all three models (all pairwise p >= 0.568; within-model ranges 0.011-0.028 nats), while task accuracy varies substantially across the same conditions (0%-100%). Entropy and accuracy are orthogonal. The decoupling is scale-invariant: larger models achieve higher accuracy but identical entropy flatness. This structural incapacity is not resolvable by additional parameters or training data. Genuine epistemic grounding requires physical coupling between thermodynamic substrate state and information processing cost.

Accurate forecasting of the Volatility-Covariance Matrix (VCV) is central to regulatory capital adequacy processes such as the Internal Capital Adequacy Assessment Process (ICAAP) and the Comprehensive Capital Analysis and Review (CCAR). Traditional econometric models, including GARCH-family and Exponentially Weighted Moving Average (EWMA) approaches, suffer from parametric rigidity, distributional assumptions, and numerical instability under stress, leading to systematic underestimation of tail risk. This paper proposes and validates a novel Hybrid Gaussian Process Regression-Historical Simulation (GPR-HS) framework for estimating Value-at-Risk (VaR) and Expected Shortfall (ES) across a diversified portfolio of seven major global equity indices. The framework decouples the VCV estimation problem: individual asset volatilities are modelled dynamically using Univariate GPR with a Matern 5/2 kernel, while inter-asset correlations are estimated via stable historical covariance. A key methodological contribution is the Aggressive Noise Initialization (ANI) strategy, which sets the initial White Noise kernel variance equal to the empirical variance of the training returns, ensuring Gram matrix positive-definiteness, regularization, and conservative, regulatory-compliant forecasts. Evaluated using an expanding window forward-chaining cross-validation scheme over June 2020 -June 2025, the GPR-HS framework achieves regulatory compliance in the majority of test splits; including a 100% ES pass rate at the portfolio level, while outperforming the static Historical VaR benchmark in 71.4% of univariate cases by Quadratic Loss and 100% of cases by violation count.

Reliable position and shape control in tokamak plasmas requires accurate real-time regulation of several strongly coupled shape parameters. The control vectors that disentangle these couplings, referred to as \textit{virtual circuits} (VCs), enable independent shape parameter control for a specific Grad--Shafranov (GS) equilibrium. Numerical calculation of VCs is not currently feasible in real time, therefore VCs are usually computed prior to each experiment, using a small number of reference GS equilibria sampled along the desired scenario trajectory, with each VC used to control the plasma within a preset time interval. While effective near the reference equilibrium, this approach can lead to degraded performance as the plasma departs from the reference equilibrium and/or from the desired trajectory, and it complicates the design of robust control strategies for rapidly evolving plasma configurations. In this paper, we construct neural-network-based emulators of plasma shape parameters from which VCs can be derived, to provide the MAST Upgrade (MAST-U) plasma control system with state-aware VCs in real-time. To do this, we develop an extensive library of over a million simulated GS equilibria, covering a substantial portion of the MAST-U operational space. These emulators provide differentiable functions whose gradients can be rapidly computed, enabling the derivation of accurate VCs for real-time shape control. We perform extensive verification of the emulated VCs by testing whether they disentangle the control problem. The neural-network-based approach delivers high accuracy and orthogonality across a diverse range of equilibria. This work establishes the physical validity of emulated VCs as a scalable and general alternative to schedules of precomputed VCs.

The rapid integration of artificial intelligence (AI) into critical infrastructure including healthcare, finance, energy, and defense, offers transformative benefits but also conflicts with evolving regulatory and governance frameworks. This paper presents a systematic literature review (SLR) to examine the challenges of balancing AI compliance and technological innovation across critical infrastructure sectors. The review follows established SLR guidelines to extract and synthesize insights from peer-reviewed articles, report, and institutional sources published between 2020-2025. The study identifies three interrelated challenges: fragmented regulations, excessive compliance burdens for smaller to medium enterprises (SMEs), and misaligned governance models. To address these challenges, the study highlights practical governance strategies, including risk-tiered regulation, compliance by design, and explainable AI, to support scalable and trustworthy AI deployment in critical sectors. Key contributions include a concise mapping of core AI-governance challenges and a conceptual diagram illustrating their overlap, as well as actionable strategies for policymakers and practitioner to harmonize oversight with innovation.

Many real-world problems require sequential decisions under uncertainty: when to inject or withdraw gas from storage, how to rebalance a pension portfolio each month, what temperature profile to run through a pharmaceutical reactor chain. Dynamic programming solves small instances exactly but scales exponentially in state dimensions. Black-box reinforcement learning handles high-dimensional states but trains slowly and produces no sensitivities. We introduce SNAPO (Smooth Neural Adjoint Policy Optimization), a framework that embeds a neural policy inside a known, differentiable simulator, replaces hard constraints with smooth approximations, and computes exact gradients of the objective with respect to all policy parameters and all inputs in a single adjoint pass. We demonstrate SNAPO on three domains: natural gas storage (training in under a minute, 365 forward curve sensitivities at no additional cost per sensitivity), pension fund asset-liability management (6.5x-200x sensitivity speedup over bump-and-revalue, scaling with the number of risk factors), and pharmaceutical manufacturing (cross-unit sensitivities through a 4-unit process chain, with 20 ICH Q8 regulatory sensitivities from 5 adjoint passes in 74.5 milliseconds). All sensitivities are produced by the same backward pass that trains the policy, at a cost proportional to one reverse pass regardless of how many sensitivities are computed.

The delivery of traditional substance education has remained problematic due to challenges in scalability, personalization, and the currency of information in a rapidly evolving substance use landscape. While artificial intelligence (AI) offers a promising frontier for enhancing educational delivery, its application in providing real-time, authoritative substance use education remains largely underexplored. We built an agentic-based AI web application that combined Drug Enforcement Administration records with peer-reviewed literature in real-time to provide transparent context-sensitive substance use education. The system uses retrieval-augmented generation with a carefully filtered corpus of 102 documents and dynamic PubMed queries. Document storage was semantically chunked and placed in a vector representation in order to be easily retrieved. We conducted an expert evaluation study in which a panel of five subject matter experts generated 30 domain-specific questions, and two independent raters assessed 90 system interactions (30 primary questions plus two contextual follow-ups each) using a five-point Likert scale across four criteria: factual accuracy, citation quality, contextual coherence, and regulatory appropriateness. Mean ratings ranged from 4.18 to 4.35 across the four criteria (overall category range: 4.05-4.52), with substantial inter-rater agreement (Cohen's kappa = 0.78). These findings suggest that agentic AI architectures integrating authoritative regulatory sources with real-time scientific literature represent a promising direction for scalable, accurate, and verifiable health education delivery, warranting further evaluation through longitudinal user studies.

Gene Regulatory Network (GRN) inference is essential for understanding complex cellular mechanisms, rendered tractable through single-cell transcriptomic data. With the emergence of single-cell Foundation Models (scFMs), enhanced transcriptomic encoding is widely expected to revolutionize GRN inference. However, we observe that their performance remains far from satisfactory. The primary reason is that the standard reconstruction-based pre-training objectives often fail to explicitly capture latent regulatory signals. To bridge this gap, we first introduce a GRN generalization benchmark designed to evaluate regulatory predictions on unseen genes and datasets, which relies on the zero-shot capabilities of scFMs and is inherently challenging for traditional methods. Furthermore, to unlock the regulatory knowledge within the foundation models, we propose two novel methods, Virtual Value Perturbation and Gradient Trajectory, to distill implicit regulatory information from scFMs into highly generalizable inter-gene features. Extensive experiments demonstrate that our approach significantly outperforms existing methods, establishing a new paradigm for leveraging the potential of scFMs in universal GRN inference.

The inception of Large Language Models (LLMs) has catalyzed AI adoption in the finance sector, yet their reliability in complex, jurisdiction-specific tasks like Indian Chartered Accountancy (CA) remains limited. The models display difficulty in executing numerical tasks which require multiple steps while also needing advanced knowledge about legal regulations and the method of scaling their operations is not feasible in settings which have limited access to resources. We present CA-ThinkFlow as a parameter-efficient Retrieval-Augmented Generation (RAG) framework which operates with a 14B, 4-bit-quantized reasoning model, 14B-DeepSeek-R1, and a layout-aware Docling extraction system which maintains document structure during extraction. CA-ThinkFlow uses a basic RAG method which automatically adds retrieved information into the prompt, while it depends on the model's built-in Chain-of-Thought (CoT) functions to create context and produce correct answers. The system we developed system operates at performance levels which match large proprietary models when we tested it on the multi-level CA-Ben benchmark, achieving Scholastic Reliability Coefficient (SRC) results which equal 68.75% of GPT-4o and Claude 3.5 Sonnet. The framework shows high efficiency and strength in handling parameters, but essential reasoning abilities fail to process complex regulatory texts which exist in fields such as Taxation.

Large language models (LLMs) are now being explored for defense applications that require reliable and legally compliant decision support. They also hold significant potential to enhance decision making, coordination, and operational efficiency in military contexts. These uses demand evaluation methods that reflect the doctrinal standards that guide real military operations. Existing safety benchmarks focus on general social risks and do not test whether models follow the legal and ethical rules that govern real military operations. To address this gap, we introduce ARMOR 2025, a military aligned safety benchmark grounded in three core military doctrines the Law of War, the Rules of Engagement, and the Joint Ethics Regulation. We extract doctrinal text from these sources and generate multiple choice questions that preserve the intended meaning of each rule. The benchmark is organized through a taxonomy informed by the Observe Orient Decide Act (OODA) decision making framework. This structure enables systematic testing of accuracy and refusal across military relevant decision types. This benchmark features a structured 12-category taxonomy, 519 doctrinally grounded prompts, and rigorous evaluation procedures applied to 21 commercial LLMs. Evaluation results reveal critical gaps in safety alignment for military applications.

Large language models (LLMs) and multimodal large models (MLLMs) are increasingly used for transportation tasks such as regulation question answering, traffic management support, engineering review, and autonomous-driving scene reasoning. Yet transportation workflows are rule-intensive, computation-intensive, safety-critical, and inherently multimodal. Existing general benchmarks provide limited evidence of whether a model can apply regulations correctly, perform verifiable engineering calculations, or interpret traffic scenes reliably, while the small number of public transportation benchmarks remain narrow in scope and rarely support fine-grained diagnosis across text, images, and point-cloud data. To address this gap, we present TRIP-Evaluate, an open multimodal benchmark for large models in transportation. The benchmark organizes 837 items using a role-task-knowledge taxonomy that covers vehicle, traffic-management, traveler, and planning-and-design functions. Each item is annotated with capability, modality, and difficulty labels, enabling diagnosis from overall accuracy down to specific failure modes. The current release includes 596 text items, 198 image items, and 43 point-cloud items. TRIP-Evaluate also standardizes item construction, quality control, prompting, decoding, and scoring to improve cross-model comparability. Results on a diverse panel of models show that text-based performance is improving, but substantial weaknesses remain in multi-step engineering calculation, rule-constrained reasoning, multimodal scene understanding, and point-cloud understanding. Overall, TRIP-Evaluate provides a reproducible, diagnosable, and engineering-aligned evaluation baseline for model selection, regression testing, and safer deployment in transportation applications.