Image Registration

Image registration and fusion aim to establish spatial correspondences from misaligned multi-modal source images, and integrate complementary information. However, in real-world imaging scenarios, source images are often affected by complex and diverse degradations, such as low illumination, noise, etc., which severely hinder the effectiveness of registration and fusion. To address this issue, we propose a mutually reinforced image registration and fusion diffusion framework via degradation-aware learning, termed Diff-RF. It explores the intrinsic coupling between registration-fusion and information restoration in the degradation conditions, enabling high-quality fusion of unregistered images under complex degradation conditions. First, the intra-modal restoration module is designed to alleviate modality-specific degradations by leveraging information within each modality, thereby providing more reliable structural representations for registration and facilitating subsequent cross-modal fusion. Second, we develop a cross-modal diffusion registration and fusion module that establishes bidirectional interaction between registration and fusion. By integrating fusion-derived visual cues and correspondence-based geometric conditions into the diffusion process, the proposed framework progressively refines spatial alignment and exploits cross-modal complementary information to achieve collaborative enhancement. Rather than treating them as independent components, degradation-aware information restoration and the collaborative optimization of registration and fusion are tightly coupled, achieving overall performance improvements. Extensive experiments on multiple extended datasets demonstrate that Diff-RF achieves superior registration accuracy and fusion quality under various degraded scenarios, exhibiting strong robustness and generalization ability.

Conventional image registration algorithms are robust to domain shifts and achieve low errors, but they are slow and computationally expensive. Deep-learning methods are efficient at inference-time, but face challenges in out-of-domain samples. We propose Recursive Uncertainty-Gated Image Registration (RUGI), an algorithm for iteratively refining deformation fields predicted by learning-based registration models. At each iteration, the registration model predicts an incremental deformation, and a gating map modulates the update. Refinements are hence concentrated in regions that remain difficult to register. We explore two gating strategies: a learned uncertainty-based approach and an image residual error approach. We evaluate RUGI on cardiac MRI and echocardiography datasets and show consistent improvements over single-step inference. Ablation experiments demonstrate that iterative refinement alone improves registration, but informative spatial gating provides a significant additional benefit. The error-gated variant of RUGI can also be applied directly to existing pretrained models; applied to VoxelMorph, TransMorph, and CycleMorph, it yields MSE reductions of 27-37% with no modification to the original training procedure. The improvements in registration performance are reflected in decreased errors in ejection fraction estimation relative to ground truths. These results demonstrate that spatially selective iterative refinement provides an effective strategy to improve registration accuracy at inference-time.

Diffusion-weighted imaging (DWI) remains highly vulnerable to subject motion, particularly in time-efficient protocols and in motion-prone populations. While slice-to-volume registration (SVR) can mitigate inter-slice and inter-stack misalignment, diffusion MRI introduces additional complexity due to diffusion-direction-dependent contrast and the requirement to align dozens of measurements within a common reference frame, effectively yielding a 4D registration problem. Existing approaches rely primarily on sequential modeling or pairwise similarity and often degrade under sparse gradient sampling or severe motion. We introduce GraphSVR, a q-space-aware graph-based framework for 4D SVR registration in DWI. GraphSVR represents slice groups as nodes in an acquisition-structured graph, with edges encoding temporal proximity, spatial slice geometry and diffusion encoding relationships. A graph neural network predicts globally consistent stack-wise rigid motion, optimized in a self-supervised, zero-shot manner using only an anatomical reference image, without requiring paired ground-truth motion. We evaluate GraphSVR using both fully synthetic diffusion simulations and realistic recombination-based simulations from real acquisitions with controllable motion severity and gradient sparsity. Performance is quantified using grid error (mm) and rotation error relative to known ground-truth transforms. Under severe motion, GraphSVR reduces grid error and rotation error by 73% compared to FSL eddy, the standard DWI motion-correction method, with the largest gains observed in sparse-direction regimes. These results demonstrate that explicitly modeling acquisition structure through graph-based reasoning improves robustness and global consistency in 4D DWI motion estimation. Code is available at https://github.com/nogakertes/GraphSVR.git.

Confocal Laser Endomicroscopy (CLE) provides real-time, cellular-resolution optical biopsy but has a narrow field of view, which image mosaicing can extend to provide anatomical context. Because of line-by-line acquisition, probe motion, and probe-tissue interaction, frame alignment generally requires a non-linear transformation whose accuracy is difficult to quantify: flexible transformation models can fit intensity features and noise, so appearance-based metrics such as Normalized Cross-Correlation (NCC) can improve without a genuine gain in geometric accuracy. We therefore establish a dataset of 132 frame pairs across fourteen pCLE sequences from 4 patients with manually annotated landmark correspondences, so that Target Registration Error (TRE) can serve as a geometrically grounded complement to NCC. We assess the effect of progressively increasing the transformation model's degrees of freedom, from translation to Thin Plate Spline (TPS), and of six feature-matching backends spanning classical (Shi-Tomasi, Lucas-Kanade) and learned (SuperPoint, SuperGlue, LightGlue, LoFTR, RoMa) approaches. Translation and rigid models prove insufficient under tissue deformation, while TPS with random sampling achieves the strongest landmark-derived alignment of the evaluated configurations; among the learned matchers, used without fine-tuning, only RoMa offers a robust, if modest, advantage over other methods. At the sequence level, pairwise registration quality proved an unreliable predictor of final mosaic quality, so mosaic quality must be evaluated directly rather than inferred from pairwise metrics.

Automated quality assessment, enhancement, and segmentation of multiple structures in $0.064\,\mathrm{T}$ ultra-low-field pediatric MRI are limited by a low signal-to-noise ratio, weak anatomical boundaries, and frequent artifacts. We present a unified framework for the LISA 2026 Challenge that performs all three tasks together within one inference pipeline. A network with two coupled streams, built on a 3D U-Net, first reconstructs an enhanced uLF volume and then combines the original and enhanced images for subcortical segmentation. To improve boundary stability, we add an auxiliary class covering brain tissue outside the target structures, derived from whole brain masks. A head conditioned on an artifact graph predicts the seven artifact ratings from reconstruction residuals and frozen segmentation features. We address the scarcity of dense annotations using diffeomorphic registration from atlas to target for label propagation and to regularize anatomical reconstruction. We report validation results across all three tasks.

We propose a new probabilistic model for general-purpose medical image registration that builds upon the mutual information registration criterion. It centers around a spatial interpolation technique that assumes latent voxel-wise correspondences between the images being registered. By exploiting these latent variables, we derive dedicated optimization and MCMC sampling techniques that only involve closed-form iterative updates. When applied to nonlinear registration, an efficient demons-like optimization algorithm is obtained that shows robust out-of-the-box performance across a variety of monomodal and multimodal registration tasks. We also demonstrate a corresponding sampler that can quantify, for the first time, uncertainty in multimodal registration scenarios with very high-dimensional 3D deformations. Our code, which we call BINDER (Bayesian INference for DEformable Registration), is freely available at https://github.com/ste93ste/BINDER.

Autonomous underwater navigation typically relies on complex and expensive multi-modal sensor suites designed to prioritize global Simultaneous Localization and Mapping (SLAM) accuracy. However, local reactive behaviors such as coarse navigation and obstacle avoidance require only local consistency---a capability that should be feasible using only a Forward-Looking Sonar (FLS), yet remains largely unaddressed, leaving a critical gap in FLS-only local SLAM. Moreover, existing acoustic SLAM frameworks predominantly rely on sparse feature extraction methods that discard substantial portions of the already information-sparse acoustic returns. To overcome these limitations, this work introduces a dense direct registration approach that aligns full acoustic intensity scans to a recursively updated local map. Real-time execution is achieved via an Inverse Compositional Gauss-Newton optimization strategy that minimizes computational overhead. Experimental evaluations show that this dense method yields significant improvements on translation error compared to sparse keypoint baselines, maintaining stable sub-meter tracking precision over wide displacement gaps. Moreover, this approach delivers odometry performance comparable to multi-sensor fusion pipelines (FLS, DVL, and IMU), bypassing expensive payload dependencies in feature-rich environments. We validate real-world applicability through AUV field trials, running the full local SLAM approach onboard an embedded, resource-constrained computer.

Full-context neural visual geometry is impractical for thousands of images, while sequence-based chunking poorly captures irregular non-local overlap in multi-sequence aerial collections. We present Graph-Guided Neural Visual Geometry for Aerial Registration (G3AR), a graph-guided framework for scalable dense neural geometry. Before local inference, G3AR builds a geometrically verified image-proximity graph that guides bounded overlapping chunks and induces a chunk graph whose maximum spanning tree defines alignment topology. Compatible backbones process chunks independently; shared-image predictions then estimate three-dimensional similarity (Sim(3)) transforms that register local cameras and geometry in a common frame. Across four real aerial scenes, G3AR improves pose error and runtime in matched VGGT- and Pi3-backed comparisons, while its DA3 variant achieves the lowest pose error among evaluated neural-geometry methods.

Multimodal image registration is a key component of many clinical workflows, yet it remains challenging because corresponding anatomical structures often exhibit substantially different image intensities across modalities. In this work, we present a comprehensive benchmark of intra-patient 3D multimodal deformable registration methods across three datasets covering different anatomical regions and difficulty levels, including both synthetic deformation recovery and real clinical scenarios. We evaluate classical optimization-based approaches and modern learning-based methods, including recent deep learning and foundation models, using complementary metrics: Average Dice similarity coefficient (DSC), average 95th-percentile Hausdorff distance (HD95), and a modality-independent structural similarity measure based on the MIND self-similarity context (MIND-SSC). Results show high variability across datasets, with learning-based methods demonstrating superior performance on large synthetic benchmarks, while only limited improvements are observed in real pelvic registration. A key finding of this study is the consistent disagreement between geometric metrics (DSC, HD95) and image-based similarity metrics (MIND-SSC), highlighting that improved overlap does not necessarily imply better global multimodal correspondence. Furthermore, anatomy-guided approaches achieve the highest overlap scores but exhibit degraded performance outside of segmented regions, revealing a trade-off between label-driven alignment and global structural coherence. Overall, our results indicate that no current method achieves robust performance across anatomies and modalities. We demonstrate that intra-patient 3D multimodal registration requires multi-criteria evaluation, including deformation-based metrics, and remains an open problem.

Unsupervised registration of large-scale LiDAR point clouds remains challenging due to the geometric ambiguity inherent in outdoor scenes, which degrades pseudo-label quality and leads to suboptimal convergence, particularly for sparse, low-resolution scans such as those from nuScenes. We reveal that registration models intrinsically encode semantic awareness that strongly correlates with registration accuracy, albeit without explicit semantic supervision. However, this native awareness is fragile: noisy supervision arising from geometric ambiguity in unsupervised settings rapidly erodes the learned semantic structure, causing performance collapse. To this end, we propose CAESAR, a teacher-student framework guided by an off-the-shelf 3D segmentation model exclusively during training. We observe that potential inlier matches are often buried just beneath a few spurious neighbors in the noisy feature space, motivating Dual-Cue Guided Re-Matching to recover them through reselection rather than simply rejecting. Building on this, a train-only Semantic-Geometric Label Mining performs lightweight, batch-specific teacher refinement and mines reliable pseudo-labels under semantic guidance. We further introduce Semantic Predictive Distillation to consolidate the student's semantic awareness in the feature space. Extensive experiments on KITTI and nuScenes demonstrate state-of-the-art performance, with pronounced gains on the challenging nuScenes benchmark. Crucially, CAESAR incurs zero inference overhead and requires no semantic annotations on the registration data. Code will be released.

We present DRS-VPT, a feed-forward transformer architecture for foundational image-to-scan registration. Given query images and a reference 3D point cloud, the model predicts the scan pose and point map alongside the poses and point maps of each camera, all expressed in the first camera's frame. It additionally predicts a coarse-to- fine pyramid of per-point and per-pixel features for direct reprojective alignment of the scan to the first image. This formulation unifies downstream tasks such as camera-LiDAR calibration in autonomous driving and indoor camera-to-map relocalization. A single DRS-VPT model achieves state-of-the-art performance for image-to-LiDAR registration in autonomous driving, competitive indoor relocalization without training map-specific weights, and strong zero-shot transfer to unseen environments. We also show qualitatively that the model learns complex scan-to-image projection properties such as occlusion of back-facing points.

Diffeomorphic image registration is central to medical image analysis, enabling anatomically consistent alignment across subjects. Most learning-based diffeomorphic methods model autonomous ODEs(ordinary differential equations) by parameterizing a stationary velocity field and recovering deformations via scaling-and-squaring. While non-autonomous ODEs with time-dependent velocities increase expressiveness, existing approaches rely on numerical integration to implicitly enforce flow structure that entangles model expressiveness with discretization accuracy. We propose a framework to directly learn the continuous-time solution of a non-autonomous ODE formulated as a two-parameterflow map. By enforcing cocycle consistency, a fundamental structural property of time-varying flows, we learn the flow maps without time discretization and velocity integration during training. The framework recovers diffeomorphic mappings at inference using a small number of compositions. Our proposed framework seamlessly incorporates standard registration backbones and improves alignment accuracy consistently across nine datasets while preserving diffeomorphic structure. Notably, the proposed method achieves an average Dice improvement of 2.1% on brain MRI benchmarks, a 12% TRE reduction on lung CT, and a 2.6% Dice gain on cardiac MRI and ultrasound datasets.

Reliable non-rigid point cloud correspondences are important for deformable anatomical registration, embodied perception and manipulation, and dynamic 3D reconstruction. Coarse-to-fine methods reduce computational cost by selecting the top-$K$ coarse regions. However, this pruning may remove weak but correct hypotheses and restrict fine matching to an incomplete search space. We present \paper, a two-stage generative solver that maintains the complete soft matching matrix at both coarse and high resolutions. StageI uses denoising diffusion to estimate a global matching matrix in the compact coarse-resolution space. We then lift this matrix to high resolution while preserving its hierarchy. The lifted matrix is rank-bounded and block-constant. StageII refines it through a conditional transport bridge. We implement the bridge with two types of dynamics: a deterministic endpoint-parameterized conditional Flow Matching (CFM) ODE and a stochastic Brownian-bridge SDE inspired by Schr"odinger bridges. Both variants share the lifted source, a time-conditioned transformer, and a matching-matrix endpoint predictor. Experiments on 4DMatch and 4DLoMatch show that both variants produce more accurate correspondences than the compared methods and improve downstream registration, with larger gains in low-overlap cases. They also improve cross-dataset generalization on CAPE and DeepDeform without target-domain adaptation while using the same deformation solver.

Adapting natural-image foundation models like DINOv3 to multi-modal medical imaging is challenging due to the significant domain gap between natural color images and multi-channel medical scans. We present a unified, patch-based framework that processes raw multimodal imaging through training-free registration, automated localization, and mask-filtered patch extraction. This architecture culminates in a hierarchical strategy that aggregates patch-level insights into subject-level diagnostics. Using liver fibrosis staging as a case study, we evaluate four patch-level feature representations: handcrafted Radiomics features, learned ResNet features, pre-trained foundation model SAM-Med2D features, and frozen DINOv3 features. To ensure a controlled comparison, all models utilize the same lightweight MLP head and are evaluated across both rigid and deformable registration settings. Our training protocol focuses on mild fibrosis (S1) and cirrhosis (S4) classes only, enabling a single classifier to address both substantial fibrosis detection and cirrhosis staging. Evaluated via 10 random train (90%)/ test (10%) splits on 360 subjects from the CARE 2025 Liver Track 4 cohort, our DINOv3-based framework significantly outperforms all baselines, achieving the best classification accuracy of 78.4% for S1 and 75.8% for S4.

The representation of 3D clothed humans as standardized 2D UV texture and displacement maps over an underlying body model has long been studied. This compact representation is enticing as it enables pretrained image networks to process, generate, and edit 3D avatars, but is only useful if scans are accurately aligned and brought into correspondence via high-fidelity registration. This prerequisite has never been met, which we argue explains the limited quality of prior UV-based methods for clothed humans. Despite its significance, no public method produces high-fidelity SMPL(-X)+D registrations with UV texture from arbitrary clothed scans. We present AvaImg, a multi-stage optimization pipeline, to close this gap: it enforces body-inside-clothing constraint via signed winding numbers, made viable by a three-level efficiency cascade (~10x runtime reduced, ~95% storage saved), and recovers fine surface detail using coarse-to-fine displacement optimization. AvaImg outperforms all baselines in body fitting, shape estimation, and surface registration across six datasets, yielding textured registrations near-indistinguishable from scans (PSNR=34.48dB). For validation of AvaImg's Avatar-as-Image representation as imminently compatible with image foundation models, we auto-encode our UV maps via the frozen FLUX VAE. This achieves only 0.76mm added Chamfer error relative to scan and shows that the resulting maps lie within natural-image distributions, supporting the use of 2D generative priors for 3D avatar generation. Code, data, and Singularity containers will be at https://yuxuan-xue.com/avaimg.

The larval stage of Drosophila melanogaster is a compact model system for neuroscience whose genetic toolkit allows fluorescent markers to be expressed in defined neural populations, and comparing the resulting expression patterns across animals requires every brain to be registered into a shared anatomical reference space. Existing pipelines for this task are predominantly based on classical registration methods, which perform a new optimization for each volume, often require per-case parameter tuning, and can take minutes per brain, limiting their use as a routine preprocessing step. We present a trained deep registration pipeline that deformably aligns a larval brain to a reference template in a single forward pass at high spatial resolution, on volumes that hold several times more voxels than those learned 3D registration is normally reported on, together with the preprocessing and anatomy-anchored evaluation pipeline required to apply it. Against eleven classical and seven further learned baselines on a held-out collection acquired with different acquisition and quality strata, the proposed pipeline is the most accurate, improving on the strongest classical baseline by 23 percentage points of anatomical landmark-local mutual information. It registers a volume one to two orders of magnitude faster than the classical deformable pipelines, and it retains more of its accuracy than any other method as acquisition quality degrades. The network, its trained weights and the full pipeline are released as the open-source deep larval brain registration framework: https://github.com/agentdr1/deep-larval-brain-reg

Longitudinal characterization of multiple sclerosis (MS) lesions remains constrained by the lack of frameworks capable of establishing consistent instance-level correspondences across time. Conventional segmentation approaches produce semantic lesion masks at each visit and therefore fail to capture the complex instance temporal patterns associated with lesion appearance, disappearance, splitting, or merging. This study presents a comparative evaluation of five strategies for automated tracking of spinal cord MS lesions in longitudinal MRI data from a multi-site cohort. The investigated strategies rely either on deformable registration or on a spinal anatomical reference system, and encompass overlap-based matching, coordinate-based Hungarian algorithm, gradient-boosted classification, and Siamese model classification. Tracking accuracy is quantified using instance-level true positives, false positives, and false negatives, allowing to assess the presence of one-to-many and many-to-one associations. Results show best performance for the registration-based overlap method. This study provides the first systematic analysis of lesion-instance correspondence in the spinal cord and outlines the strengths and limitations of registration-based and registration-free paradigms for longitudinal MS assessment. The code is available at http://github.com/ivadomed/longitudinal-sc-ms-lesion-tracking .

Preoperative evaluation of trigeminal neuralgia (TN) often requires joint interpretation of structural MRI, which depicts the trigeminal nerve and surrounding cisternal anatomy, and time-of-flight MRA, which highlights vascular structures. Although MRI-MRA fusion is clinically attractive for visualizing neurovascular compression, this task is poorly captured by conventional whole-brain registration evaluation because the clinically relevant target is a small trigeminal ROI, vessel annotations are partial and clinically focused, local TOF-MRA contrast is variable, and field-of-view mismatch can limit deformable alignment. We formulate TN MRI-MRA fusion as an ROI-centered neurovascular registration-evaluation problem and construct a benchmark from 149 patients with clinician-annotated bilateral trigeminal ROIs. Six representative registration pipelines were evaluated using local image-based metrics, segmentation-derived vessel-localization metrics, prediction-volume analysis, and contrast- and FOV-stratified comparisons. Conventional evaluation summaries were often misleading: local image similarity, vessel-background separability, and downstream vessel localization did not co-rank methods; one-sided vessel distances were strongly affected by predicted vessel extent under partial annotations; and local MRA contrast determined when vessel-separability metrics were informative. Deformable refinement provided only a small, FOV-dependent benefit over affine alignment, while reader review showed that locally favorable vessel distances could coexist with globally implausible registrations. These findings indicate that TN MRI-MRA registration should be evaluated as a local, vessel-aware, contrast-sensitive, and FOV-aware visualization task rather than as generic multimodal brain registration. Our code is publicly available at https://github.com/jhuldr/TN-Reg-Benchmark.

Non-destructive X-ray and computed tomography (CT) testing are essential for ensuring the dimensional accuracy of manufactured components with complex internal structures, such as the cooling channels in gas turbine blades, which directly affect thermal performance and service life. This study presents a multipart 3D-2D rigid registration approach for aligning CAD models with X-ray projections as an alternative to CT reconstruction for part inspection and measurement. A greedy registration algorithm sequentially aligns the blade's exterior before registering its internal components by maximizing the mutual information between simulated and acquired X-ray images. This stepwise approach reduces problem complexity and improves alignment accuracy. View angles are optimized using a greedy method that iteratively selects angles to minimize dimensional measurement errors. The results indicate that a small number of oblique views provides the best accuracy, although a broad range of angles yields acceptable results. The method achieves subpixel registration accuracy, with errors below one-fifth of the magnified detector-pixel pitch. Image noise and defects reduce registration precision, but direct registration in projection space mitigates these effects compared with CT reconstruction. Appropriate view selection can therefore preserve acceptable subpixel accuracy in the presence of image noise and defects.

Magnetic resonance images of the same subject look markedly different across field strengths, which complicates the comparison and pooling of data across sites. We address cross-field brain-MRI translation for the MRIxFields2026 challenge, and in particular its Task~3: a single model that translates between any directed pair of the five field strengths and across three contrasts. We phrase the problem as a conditional flow matching path: because the source and target volumes are spatially registered, we learn a velocity field that carries the source slice directly to the target slice, rather than starting from noise. To learn this mapping from only three paired subjects, the unified model is trained in three stages: a degradation-bridge pretraining that distills a restoration prior from the abundant unpaired retrospective cohort, a cross-field finetuning over all directed pairs on the paired cohort, and an adversarial refinement that sharpens the output. At inference, we integrate the learned velocity with a second-order Heun solver in a handful of steps. A restoration prior learned without any paired data already reaches a mean SSIM of 0.837, and each subsequent training stage improves on it. A single 6.3M-parameter model thereby covers all 60 field-pair and contrast combinations, with inference in five solver steps per slice. On the challenge evaluation set the model reaches a mean SSIM of 0.909, averaged over the three contrasts, outperforming regression and diffusion baselines built on the identical network on all three challenge metrics.

Dense voxel-level annotation remains a major bottleneck in 3D medical image segmentation. Single-slice propagation methods such as Sli2Vol reduce this burden by propagating one annotated seed slice through a volume using label-free registration. However, axial-only propagation accumulates errors with distance from the seed, especially in surface-distance metrics, because it ignores coronal and sagittal evidence and therefore underuses the 3D information available in CT/MRI volumes. To better leverage volumetric geometry, we study how key training and inference choices affect slice-propagation models, including single-axis versus multi-axis label-free registration, single-seed versus multi-seed propagation, and orthogonal seed configurations. Instead of propagating from a single axial seed, we use three orthogonal seeds---one axial, one coronal, and one sagittal---and fuse their propagated labels with a simple label-free rule. Our results show that the training paradigm has limited impact: an axially trained network applied to off-axis seeds captures nearly all the improvement, while explicit three-axis training adds little. Instead, performance is driven by inference-time seed geometry, especially orthogonality rather than the number of annotated slices, as a budget-matched three-axial control provides no benefit and can even degrade performance. On a multi-organ CT cohort, orthogonal seeding with the axial Sli2Vol backbone improves Dice by 21.9%, Normalized Surface Dice by 25.5%, and reduces Average Hausdorff Distance by 53.5% over the single-axis baseline.

Existing 3D facial-landmark methods localize points on visible skin, but whether CT-defined internal skeletal landmarks can be inferred from external soft-tissue geometry remains unclear. We formulate a coordinate-consistent surface-to-skeleton task using same-acquisition CT-derived surfaces, separating estimation from optical-to-CT registration, scanner-domain, and acquisition-state effects, with coverage analyzed separately. From 240 clinical CT scans from two hospitals, we construct a locked retrospective protocol pairing CT-derived external soft-tissue point clouds with 21 skeletal landmarks and three visible soft-tissue landmarks. An integrated hierarchical point-cloud model achieves 2.97 mm mean radial error on skeletal landmarks and 3.03 mm on deep or surface-invisible landmarks in 40 held-out patients. Patient-mismatch controls support patient-specific signal beyond a fixed population configuration or global similarity alone, while coverage ablations indicate dependence on non-anterior geometry. Optical-transfer diagnostics reveal substantial coverage-related and global-configuration components, although deployable optical inference remains unresolved. These results answer the controlled feasibility question affirmatively and provide a basis for hidden skeletal landmark inference.

This paper proposes an algorithm for estimating the similarity transformation, namely translation, scale, and rotation, between two images with subpixel accuracy. Image registration is a fundamental technique for aligning images acquired under different viewpoints and imaging conditions, and a representative approach based on maximizing discrete cross-correlation is the Fourier--Mellin registration. However, the Fourier--Mellin approach often fails to achieve sufficient alignment accuracy when subpixel-level estimation is required. The proposed method integrates (i) scale-and-rotation estimation from the Fourier magnitude spectrum in a log-polar representation and (ii) maximization of phase-only correlation based on the auxiliary function method. This integration enables a two-stage estimation procedure: it first estimates scale and rotation without being affected by translation, and then estimates translation with subpixel precision in the spatial domain using the corrected image pair. A simulation experiment on image pairs subjected to random similarity transformations demonstrates that the proposed method reduces estimation errors in scale, rotation, and translation compared with Fourier--Mellin-based registration methods using discrete cross-correlation.

Visible-infrared object detection relies on complementary RGB and thermal cues, but its performance is often degraded by cross-modal spatial misalignment. Most existing methods rely on implicit feature adaptation to handle weakly misaligned scenarios, while large-offset geometric discrepancies remain insufficiently addressed. In this paper, we propose a Joint Feature-domain Registration and Detection network (JFRDet), an end-to-end visible-infrared oriented object detector tailored for severely cross-modal geometric discrepancies. JFRDet introduces a Cross-Modal Affine Alignment (CMAA) module to estimate an image-level affine transformation for explicit multi-level feature alignment. Note that illumination changes directly affect the reliability of RGB cues, an Illumination-Guided Complementary Fusion (IGCF) module adaptively exploits modality reliability under varying illumination conditions for cross-modal fusion. Then, an Alignment Quality-Consistency Gating (AQCG) strategy stabilizes joint optimization by modulating detection supervision according to alignment reliability and gradient consistency. We further construct DroneVehicle Misaligned (DVMA), a benchmark for evaluating visible-infrared oriented object detection under severe cross-modal geometric misalignment. The proposed JFRDet achieves 69.7% $\mathrm{mAP}_{50}$ on DVMA, which represents state-of-the-art (SOTA) performance. The code and dataset will be available on GitHub.

This work presents a visual odometry (VO) system that leverages image edge features. Edges are spatially expressive cues commonly present across diverse environments, offering rich textural and structural information. However, existing edge-based VO methods often fail to fully exploit this potential. To this end, we introduce a novel feature representation termed \textit{organized edges}, which transforms disjoint edge pixels into sequentialized clusters, enabling more effective retention and utilization of the underlying textural and structural information. Another nice property of this formulation is that organized edges can perform edge-level association across multiple frames, enabling the establishment of a co-visibility graph. To achieve precise and efficient pose estimation, we propose a range of particularly designed tracking and joint optimization methods based on the characteristics of organized edges. For tracking, we formulate edge-wise rather than pixel-wise residuals to achieve robust and accurate inter-frame registration. For joint optimization, we introduce a novel shape-preserving edge-fitting method and an organized edge-based Bundle Adjustment (BA) approach, which decomposes the traditional BA problem into fitting and registration to preserve the structural integrity. Based on these novel techniques, we develop a complete VO system that exclusively employs organized edge features, achieving efficient tracking and precise local mapping. Extensive experiments demonstrate its accuracy and robustness in indoor environments, outperforming or achieving comparable performance to state-of-the-art methods. The source code is publicly available at https://github.com/liumingrui814/ROEVO

Longitudinal MRI enables sensitive measurement of structural brain change for studying aging and neurodegenerative disease. Deformable image registration is a key tool for estimating such change by computing a dense deformation that captures geometric differences between longitudinal scans. However, MRI scanners introduce geometric distortions that vary across acquisition systems and protocols, such as gradient non-linearity (GNL) distortion. Existing registration methods estimate a single field that conflates biological and technical effects, potentially biasing downstream morphometric measurements if distortions remain (partially) uncorrected. We propose $\texttt{DisMorph}$, a registration framework trained entirely on synthetic data that explicitly decomposes longitudinal deformation into technical and anatomical transforms. It predicts two dense deformations, each encoding one effect. During training, a novel generative model synthesizes both effects separately to provide disentanglement supervision, while domain randomization promotes generalization across imaging protocols. We evaluate our method in three complementary settings. On simulated data with known ground truth, our method detects anatomical change more accurately and consistently than conventional registration. On real image pairs that differ only by GNL distortion, our method assigns most geometric change to the distortion field, demonstrating specificity in the absence of anatomical change. On longitudinal Alzheimer's disease (AD) pairs, our method detects anatomical change in AD-related brain structures while identifying residual distortion left after standard correction. By disentangling MRI-induced distortion from biological change in the longitudinal deformation, our method paves the way for more accurate longitudinal morphometry in clinical settings where maintaining acquisition consistency is challenging.

Registration-based Few-shot medical image segmentation (RFMIS) aims to generate pseudo-labels for unlabeled images by warping a labeled image through registration. However, existing methods primarily perform pixel-level optimization and inference in Euclidean space, treating anatomical structures as flat and disjoint. This neglect of inherent hierarchies degrades pseudo-label quality and weakens the discrimination of ambiguous regions, limiting the segmentation performance. To overcome this challenge, we propose a Hyperbolic Hierarchy-aware Aggregative Learning framework for RFMIS, termed H2AL, that enhances both deformation plausibility and anatomical discrimination for dual-task learning. Specifically, we introduce a Hyperbolic Hierarchy-aware Infusion (H2I) module, which leverages the hierarchical modeling capability of hyperbolic space to learn precise hierarchy-aware representations via transformation-guided supervised hyperbolic contrastive learning, and injects such hierarchical priors into Euclidean space through a gated infusion block while preserving semantic richness. Furthermore, we propose an end-to-end joint optimization algorithm by gradient aggregation, where the gradients from the registration and segmentation decoders, embedding semantic and hierarchical cues, are aggregated to update the shared encoder to promote collaborative learning across tasks. Extensive experiments on two anatomical regions, with five experimental settings, demonstrate the effectiveness and efficiency of our method in both registration and segmentation. The code is publicly available at https://github.com/JiamingCai469/H2AL.

Registration between cone-beam computed tomography (CBCT) and intraoral scans (IOS) is essential for patient-specific surgical planning. However, disparate imaging modalities, limited overlap, and large pose offsets make automated registration unreliable. Consequently, clinical registration remains dependent on conventional geometry pipelines and manual clinician adjustment. To address these challenges, we propose APCReg, an anatomical-prior-guided coarse-to-fine framework for global registration and reliability-controlled residual correction. Specifically, multi-view anatomical coarse registration (MACR) performs ordered orthogonal projection alignment (buccal, proximal, and occlusal) to decompose the six-degree-of-freedom search before three-dimensional refinement. Overlap-aware residual registration (OARR) combines shared KPConv features, a folded arch-length cue, overlap-gated cross-attention, and Sinkhorn matching. Finally, dental-arch-structured hypothesis selection evaluates diverse poses on held-out reliable correspondences, while a ground-truth-free coarse-retention guard conditionally retains a geometrically reliable coarse pose. On 60 held-out jaw pairs, APCReg achieves a submillimeter mean Chamfer distance of 0.87 mm and a Hausdorff distance of 2.92 mm under this evaluation protocol, and ranks first across the six reported metrics among the evaluated open-source baselines.

The plethora of readily available geospatial data offers exciting opportunities to learn high quality representations of the planet, but the sheer size of the Earth Observations (EO), differing modalities, and different sensor types pose significant challenges in doing so. Location encoders have emerged as an efficient way of compressing EOs into location-specific embeddings. However, current state-of-the-art location encoders rely on computationally expensive CLIP-style frameworks that require large batch sizes in the 16K--32K range, suffer from false negative samples, and scale poorly with additional modalities. We introduce the Scalable Location Encoder via Distillation (SLED), a distillation-based location encoder that uses geospatial location as a binding modality to pretrain location encoders with any modality of geospatial data. The resulting location encoder framework is lightweight, modular, and can flexibly incorporate multiple modes, while eliminating the need for spatiotemporal coregistration of samples. SLED is performant with batch sizes as small as 128, enabling pretraining at a fraction of the runtime and compute costs of current state-of-the-art models. We demonstrate our approach by pretraining unimodal and multimodal SLED models on Sentinel-1, Sentinel-2, and Landsat imagery. We show that both unimodal and multimodal SLED models keep pace with or outperform existing approaches on a diverse set of 19 human-centric benchmark tasks and explore the benefits of using additional modes in pretraining.

Mandibular reconstruction restores facial continuity and oral function after segmental resection. Patient-specific cutting guides transfer a computed tomography (CT)-based plan to the operating room with three-dimensional information, but printed guides add cost and lead time, cannot adapt after fabrication, and may interrupt surgery if sterility is lost. We investigate a markerless augmented reality (AR) alternative that registers a virtual cutting guide to the exposed mandible from surface geometry. The method extends surface-based registration for the transoral setting, where teeth form the most distinctive visible surface. After camera calibration, a HoloLens 2 time-of-flight camera captures a partial intraoperative point cloud. The user supplies a rough head-based alignment only to crop the region of interest. A teeth-weighted global stage computes correspondences and solves a truncated least-squares rigid alignment. An asymmetric point-to-plane iterative closest point (ICP) stage refines the complete CT mandible against the partial depth cloud target. The guide-to-mandible transform places the guide in the HoloLens world frame, while pose updates and interpolation follow target motion. We define a blinded phantom protocol with 30 target registration error (TRE) points under full, intermediate, and teeth-only exposure, plus a motion-to-display latency test. Our median TRE is 4.05, 6.10, and 7.10 mm respectively, and median latency is 0.805 s. These values support the feasibility of using AR to replace physical prints. The workflow removes mounted fiducials and manual landmark selection and provides a testable path toward transoral cutting guidance.

3D human registration has historically been treated as a regression task, assuming a unique ground-truth alignment exists between the template and an input point cloud. In reality, acquisition noise, occlusions, and unknown soft tissue dynamics introduce inherent ambiguity into human scans. Regression-based methods consequently converge to an average prediction, often failing to represent a plausible geometry. In our work, we embrace such uncertainty by modeling the registration as a distribution of alignments. We propose ODin, which formulates registration as a 3D diffusion process that generates a point cloud aligned with the target geometry while preserving template semantics through consistent point ordering. To achieve this, ODin relies on global, local, and positional conditioning, guiding each point to its correct location. Our experiments demonstrate that such a generative formulation not only outperforms its regression-based baseline, but also establishes a new state of the art, surpassing highly engineered methods while reducing the registration time by two-thirds. Pre-trained models and code are available at https://riccardomarin.github.io/odin/.

High-definition 3D LiDAR maps are important for autonomous driving and smart-city services, which require reliable detection of object-level changes in multi-temporal urban LiDAR to keep digital maps aligned with the physical world. Existing approaches from raster height differencing to depth image and point-cloud networks often remain tile-based and threshold-driven, yielding per-point scores without explicit detection limits or consistent object-level labels. We propose an object-level 3D change-detection pipeline that integrates detection-limit-aware registration, geometry-driven object proxies with rule-based semantic and instance segmentation, and displacement cues in height, volume, and surface-normal direction to assign five change labels with confidence. By decoupling registration, geometry, and semantics, the pipeline propagates pose uncertainty into spatially varying detection limits, stabilizes cross-epoch correspondences, and suppresses false changes caused by residual misalignment and density variation. We also present LoDA, a level-of-detection (LoD) aware benchmark for the Subiaco district with fused multi-temporal vehicle-LiDAR maps constructed with LiDAR, GNSS, and IMU support, semantic instances, and object-level annotations. On this benchmark, our method achieves 95.0% accuracy, 90.8% macro F1, and 83.0% macro IoU, exceeding the best baseline by 8.7 IoU points and 4.4 F1 points. On the public Urb3DCD-V2 benchmark evaluated under the official point-wise protocol, it reaches 96.81% mean accuracy and 89.52% mean change IoU, improving over the strongest reported baselines by 1.36 points in mAcc and 3.18 points in mIoUch.

3D point cloud registration in laparoscopic surgery estimates the transformation between an intraoperative organ reconstructed from video and its preoperative mesh. Because ground-truth transformations are unavailable for real data, supervised networks are trained on synthetic organ pairs. At test time, real reconstructions differ from synthetic data and are noisy, sparse, and occluded, which degrades correspondence estimation. Test-time adaptation (TTA) can reduce this domain shift, but existing methods mainly rely on logits, entropy, class prototypes, or cache memories unavailable in registration. Registration also involves paired inputs with an asymmetric shift that primarily affects the intraoperative cloud. We analyse and modify state-of-the-art TTA methods from three families to 3D registration: model, normalization, and input adaptation. We analyze four representative approaches based on auxiliary-task model updates, backpropagation-free token purging, feature alignment, and layer-normalization calibration. We modify them to handle asymmetric shifts between preoperative and intraoperative point clouds and replace classification-based entropy objectives. Using a correspondence-based model trained on clean synthetic source data, we evaluate adaptation to corrupted synthetic and real target data on P2P and P2ILReg. For synthetic targets, we apply eight corruptions, including uniform noise and global density reduction, at five severity levels. All methods improve registration on P2P, whereas on P2ILReg only input adaptation reduces the error, while normalization adaptation degrades it. Considering the computational overhead of backpropagation-based adaptation, input adaptation is the most promising option for laparoscopic surgery, providing low inference latency and consistent error reductions across datasets. Code: https://github.com/ninaa-git/survey_pc_registration_tta

We consider optimization problems defined on product spaces of simplices. Examples of this class of problems include learning low-rank discrete multivariate probability distributions via simplex constrained tensor decomposition and performing functional data registration under the Square Root Velocity Function (SRVF) representation. In this work, we demonstrate the feasibility of replacing the product simplex with a smooth, elementwise strictly convex reparameterization, resulting in an unconstrained optimization problem on a manifold. We show that performing such a reparameterization results in the second order Karush-Kuhn-Tucker (KKT) points on the smooth manifold being mapped to the weak second order KKT points on the product simplex. This leads to a Riemannian Gradient Descent (RGD) algorithm for solving the reparameterized problem, which outperforms Projected Gradient Descent (PGD), and provides a more faithful representation of the original function shapes while performing curve registration.

Computational attention models could help surgeons manage the visual demands of laparoscopy, but they require dense spatial labels that are difficult to obtain because surgical intent is highly specialized and tacit. Here, we introduce DiffeoAfford, an action-grounded tissue affordance framework that retrospectively derives visual attention supervision from completed surgical procedures. By combining diffeomorphism-constrained tissue tracking with instrument trajectory analysis, DiffeoAfford generates affordance hotspot labels without manual per-frame annotation. A real-time prediction model trained on these labels anticipates relevant surgical regions and enables AffordView, an assistive auto-framing system for laparoscopic visualization. The proposed framework aligns with expert annotations and intraoperative surgeon gaze, and reduces surgeon cognitive workload during real-world evaluations using subjective, physiological, and behavioral measures.

In digital dentistry and oral surgery, the registration of jawbone CT and intraoral scanner (IOS) data is essential for integrating internal bone structure with high-resolution dental surface geometry. However, this registration is challenging because the two modalities share only a limited region in common, and their true correspondence is generally unknown. This uncertainty has prevented rigorous quantitative evaluation of registration accuracy. In this study, we propose a pseudoIOS evaluation framework in which a point cloud emulating an intraoral scan is generated from CT data within the same coordinate frame, so that the transformation between them is known by construction and can serve as a true ground truth. Using this framework, we propose a coarse-to-fine registration method that combines a domain-generalizable local descriptor (GeDi) for initialization-independent global alignment with the iterative closest point (ICP) algorithm for local refinement, and also evaluate the influence of metal artifacts on registration. In experiments on seven cases, ICP alone frequently converged to local minima from a perturbed initial position, whereas GeDi$+$ICP maintained submillimeter mean absolute error (MAE) across all evaluated jaw and artifact conditions (0.55-0.69 mm). A three-way repeated-measures analysis confirmed that GeDi$+$ICP was significantly more accurate than GeDi alone. Metal artifacts had a statistically detectable overall effect, but their absolute impact on GeDi$+$ICP was small.

Deformable image registration (DIR) is a core problem in medical image analysis; but, unlike labeling decision problems such as classification and segmentation, registration is a problem class that involves stringent physical constraints. Although deep learning methods have made faster registration possible, the resulting models are often difficult to interpret compared to hand-crafted methods with explicit objectives and interpretable physical meaning. In this work, we show that an analytical method can still yield competitive and superior results to deep learning in a common deformable registration task. We study pTVreg as a parametric total variation based registration in that context. Observing its different implementations to perform at various degrees, we introduce here an accessible implementation of this method, together with a Bayesian optimization framework that automatically sets self-parameters for any DIR task from a set of sample examples. Experiments on Lung250M-4B show that our proposed implementation achieves state-of-the-art results in this benchmark, substantially superior to existing deep learning solutions and other pTVreg variants as baselines. The source code will be made publicly available at https://github.com/oazeybekoglu/ptvreg-python .

Head-and-neck (HN) proton therapy is highly sensitive to anatomical change over a 4-to-6-week course, as tumor shrinkage, weight loss, and setup variation can misposition the Bragg peak near critical organs such as the parotids, oral cavity, brainstem, and spinal cord, leading to target underdosing or organ-at-risk overdosing. Online adaptive proton therapy replans on the anatomy of the day, yet standard workflows rely on offline replanning that requires repeated CT acquisition and roughly a week of preparation, adding burden, cost, and delay. We investigate whether a patient's treatment-day anatomy can be predicted before image acquisition by transferring longitudinal change from a population database. We propose a digital-twin framework built on a pretrained foundation-model deformable registration network used without patient-specific training. A first registration aligns a prior patient's planning CT to the target and carries the prior's during-treatment quality assurance CT (QACT) into the target frame; a second registration estimates the prior's planning-to-QACT change, which is then applied to the target's own planning CT to synthesize predicted CTs (pdCTs) with propagated contours. Using 88 HN patients, each with a planning CT and three QACTs, we show that pdCTs better match treatment-day anatomy than the static planning CT. Compared with the planning CT alone, normalized cross-correlation improves by 22.8%, Dice for organs-at-risk by 20.2%, and CT-number error decreases by 23.4%. Gains are largest for patients with major anatomical change and negligible when anatomy is stable. This cross-patient motion transfer leverages the digital-twin concept to anticipate treatment-day anatomy, enabling personalized online adaptive proton therapy without repeated imaging.

Reliable pelvic bone segmentation (PBS) from CT is essential for robot-assisted pelvic trauma surgery, yet deploying a source-trained model to a new hospital suffers from severe performance degradation due to cross-center domain shifts. While test-time adaptation (TTA) enables online model adaptation without accessing source data, existing methods show limited effectiveness for PBS, facing challenges including boundary degradation, anatomical inconsistency under domain shifts, and voxel-level class imbalance. To address these challenges, we propose a novel closed-loop dynamic Reliability-Guided TTA framework (ReGA) for PBS. Specifically, we introduce a pseudo-label reliability criterion termed Segmentation Inference Consistency Evaluation (SICE), which jointly measures region overlap and boundary deviation via dropout-based ensemble predictions. Based on SICE, a trust-weighted refinement module adaptively updates features to mitigate boundary errors in pseudo-labels. Furthermore, a confidence-weighted region-level contrastive learning strategy is proposed to enforce anatomical consistency. Finally, ReGA follows the teacher-student (TS) scheme to alleviate voxel-level class imbalance. Experiments on three heterogeneous 3D pelvic CT datasets demonstrate that ReGA consistently outperforms state-of-the-art TTA methods, enabling effective adaptation of the source-trained PBS model to unseen clinical domains. The code is available at https://github.com/Ren-ling/ReGA.

Point-cloud (PC) registration is fundamental to three-dimensional (3D) perception in robotic systems. However, classic registration algorithms falter when aligning a source PC containing limited, incomplete, or ambiguous geometric cues against a reference. This challenge of registering a small, partial PC to a significantly larger global reference is pervasive in real-world deployment yet remains insufficiently addressed by existing learning-based approaches, which typically assume comparable scales and significant overlap. To bridge this gap, we propose the Region-based Small-to-Large Point-cloud Registra- tion framework (R-SLPR), a novel three-stage architecture that fundamentally reformulates the scale-mismatched registration problem into a sequence of region proposal, regional matching, and iterative refinement. Unlike conventional methods that fail to localize specific regions, R-SLPR explicitly identifies candidate regions prior to estimating rigid transformations, ensuring robust alignment even under severe scale mismatch. The framework introduces a Fibonacci Grid Segmentation method coupled with a contrastive learning objective to effectively generate and match local geometric patches. Building on this, a novel Cascade Anchor Selection and Refinement algorithm iteratively aligns the source with the target region to maximize precision. Extensive evaluation on ModelNet40 demonstrates that R-SLPR establishes a new state-of-the-art accuracy standard, outperforming prior approaches and significantly reducing position and rotation Mean Absolute Error (MAE) to 0.009 and 1.104, respectively.

Diffusion MRI (dMRI) relies on diffusion-weighted echo-planar imaging, which is highly susceptible to eddy-current-induced geometric distortions. These distortions vary across diffusion volumes according to gradient strength and direction, causing between-volume misalignment that can bias downstream microstructural analyses. Current state-of-the-art correction methods, such as FSL Eddy, achieve high-quality correction through iterative prediction-correction schemes but are computationally expensive. We propose Eddeep, a deep-learning framework for fast eddy-current distortion correction in dMRI. Eddeep decomposes the problem into two stages. First, a supervised image translation network standardises the appearance of diffusion-weighted and b=0 images, removing contrast differences that hinder reliable registration. Second, an unsupervised registration network estimates both eddy-current distortion and between-volume head motion parameters under a physics-constrained quadratic distortion model, enabling correction in a single forward pass. The method was trained on UK Biobank data and evaluated on both in-domain (UK Biobank) and out-of-domain (Memodyn) datasets. Across a range of complementary metrics, including between-volume jitter, diffusion kurtosis imaging residuals, signal irregularity, and mutual information, Eddeep achieved correction quality comparable to that of FSL Eddy while substantially reducing inference time. These results demonstrate that deep learning can provide accurate and efficient eddy-current distortion correction without relying on iterative optimisation, supporting the development of faster diffusion MRI processing pipelines for large-scale studies and clinical deployment. The code is available at: https://github.com/CIG-UCL/eddeep.

In practical settings, medical image segmentation models are often developed with limited annotated data rather than fully labeled datasets. Training frequently begins in ultra-low labeled regimes where only a small number of volumes are annotated. In such scenarios, practitioners must simultaneously decide which cases to annotate and how to best use the remaining unlabeled data. Although active learning (AL) and semi-supervised learning (SSL) both target annotation scarcity, they are typically designed and optimized independently, resulting in objective mismatch and unstable training during early-stage "cold start" conditions. We propose RegAL, a unified active semi-supervised framework governed by a shared topology-aware Pareto optimization that couples sample acquisition with unlabeled data utilization. RegAL evaluates images along three complementary axes, voxel-wise uncertainty, feature diversity, and a novel topological consistency metric, to select anatomically informative edge cases for annotation. On the other hand, the same criteria are used to identify geometrically stable atlas candidates for diffeomorphic registration-guided augmentation to train a self-supervised Mean Teacher segmentation network. Across BraTS 2021, dHCP, and ProstateX, RegAL remains stable with few labeled volumes and consistently outperforms state-of-the-art AL, SSL, and active semi-supervised baselines across Dice and boundary-distance (ASD, HD95) metrics under extreme annotation scarcity.

Intraoperative 2D/3D registration aligns preoperative CT volumes with intraoperative X-ray or fluoroscopic images and is essential for image-guided interventions. Recent learning-based and differentiable registration methods have shown promising accuracy, especially in patient-specific settings where abundant digitally reconstructed radiographs (DRRs) can be synthesized from the target CT. However, training a separate patient-specific model from scratch for every new patient is computationally inefficient and limits practical deployment. In this work, we propose an efficient patient-specific 2D/3D registration framework based on patient-agnostic synthetic pretraining and spherical similarity learning. The model is first pretrained on synthetic DRRs generated from multiple CT volumes to learn transferable pose-sensitive representations, and is then adapted to a new patient using only a limited number of synthetic projections from the target CT. To improve synthetic-to-real robustness without requiring anatomical labels, we introduce a segmentation-free domain randomization strategy that perturbs image intensity, projection physics, field-of-view, occlusion, and fluoroscopic artifacts. The adapted model provides an initial pose estimate, which is further refined using spherical similarity learning and differentiable Levenberg-Marquardt optimization. Experiments on multiple anatomical datasets evaluate whether patient-agnostic synthetic pretraining can improve the efficiency of patient-specific registration, with particular focus on the trade-off between adaptation cost and registration accuracy. The results demonstrate that patient-agnostic synthetic pretraining can significantly reduce patient-specific training requirements while preserving accurate intraoperative 2D/3D registration.

Recovering the 6-DoF pose of the knee bones from a plain radiograph, given the patient's segmented pre-operative CT, turns a routine low-dose image into a quantitative measurement of joint geometry, without the added dose of a repeat CT or a fixed biplanar rig. Classic solutions align a rendered bone silhouette to image edges; recent alternatives refine pose by backpropagating an image-similarity loss through a differentiable X-ray renderer. Both operate one patient at a time and are fragile under a single view. Silhouettes are depth-ambiguous, and differentiable-rendering refinement has a narrow capture range at substantial per-iteration cost. We instead learn an amortized, subject-agnostic dense 2D-3D correspondence, supervised solely by projection geometry. One shared-weight model per bone, trained across 758 patients, registers patients unseen during training. The pose then follows in closed form from a global, initialization-free, render-free PnP+RANSAC solve. Because X-ray formation is transmissive, our correspondence target is transmission-aware rather than tied to a single surface. Though trained only to register, the representation is anatomically semantic: a simple classifier reads a landmark's anatomical region from its embedding across held-out patients, and the same features separate the knee's bones into a 2D-3D-consistent identity learned without any bone label. On a large single-institution cohort the model generalizes well to held-out patients.

Accurate 3D--2D liver registration, which aligns preoperative 3D models to partial, view-dependent intraoperative surface observations, is critical for AR-guided laparoscopic surgery but remains challenging due to severe occlusion, limited visibility, and the lack of 3D ground-truth supervision. Existing landmark-free approaches perform partial-to-complete geometric alignment, yet robust self-supervision under extreme partial visibility remains difficult. We propose Vis2Reg, a visibility-aware registration framework that explicitly constrains deformation using mask-consistent visible regions. We introduce a visibility-aware self-supervision that derives a visible-domain 3D supervision signal from intraoperative masks, enabled by differentiable point rasterization and mask-guided back-projection. This formulation improves robustness under severe occlusion while maintaining fully self-supervised learning. Vis2Reg combines a robust geometric rigid initialization module with an implicit neural deformation field for stable alignment. Vis2Reg achieves a Dice score of 92.6% and a Chamfer Distance of 1.43 mm on real intraoperative datasets, with 111 ms per-frame inference time, demonstrating both accuracy and practical efficiency.

Global LiDAR-to-BIM initialization must place a robot within an as-designed building model without a prior pose. In repetitive interiors, the principal failure mode is not low-confidence registration but confident aliasing: a submap can match several BIM regions with comparable scores, producing a high-scoring pose displaced by symmetry. We present Move First, Commit Later, a selective layer that treats a registration front-end as an evidence source and decides whether to commit. Candidates from multiple submaps are mapped to a common $\mathrm{SE}(2)$ anchor; a top-1 consensus $B_m$, invariant to non-champion multiplicity, aggregates cross-submap evidence; and topology serves only as a binary feasibility gate. The decision is typed--COMMIT, DEFER, or AMBIGUOUS($τ$), reporting the detected symmetry period--and reversible: symmetry-breaking motion upgrades AMBIGUOUS to COMMIT. On a real multi-room building and a controlled symmetric simulation, the layer commits correctly in every tested trajectory-scale configuration and otherwise abstains with a typed state, whereas forced-choice policies on the same front-end select wrong rooms in most cases. Committed anchors are within 0.02--0.36 m of an independent laser-tracker position reference and within $1.9^\circ$ of a BIM-registration orientation proxy. The evaluation covers one building and one front-end; the layer is designed to be front-end modular.

Image registration is essential in applications such as electronic image stabilization. Scale-Invariant Feature Transform (SIFT), a widely used local keypoint detector and descriptor, typically provides accurate registration; however, it often fails in scenes with strong linear structures (e.g., shutters), where local features become ambiguous. We propose Hough-SIFT, a robust registration method that performs SIFT descriptor matching in Hough space. In this domain, linear structures form distinctive peaks that restore descriptor discriminability. Experiments demonstrate that Hough-SIFT is robust in linear scenes where SIFT frequently fails, while maintaining accuracy comparable to SIFT in normal scenes.

High-quality maps are fundamental for robotics tasks such as navigation and planning. Although modern graph-based LiDAR SLAM systems achieve good trajectory accuracies, a low trajectory error alone does not guarantee geometrically consistent maps, particularly at revisit locations where missed loop closures and residual drift can produce local misalignments. In this work, we address the problem of jointly improving global trajectory estimation and local map quality in 3D LiDAR SLAM. We first propose a framework to efficiently estimate geometry-dependent information matrices for ICP, enabling principled weighting of odometry constraints in a pose graph. We then introduce a hierarchical loop-closure module that decouples place recognition from geometric registration, together with a retroactive loop-closure module that exploits the optimized pose graph to recover missed loop closures. We also propose an evaluation protocol to measure map consistency at revisit locations. We evaluate our SLAM system on several datasets against state-of-the-art LiDAR SLAM systems. Experimental results demonstrate global trajectory accuracies on par with or better than existing methods while consistently improving local geometric map consistency at revisit locations. These results suggest that coupling uncertainty-aware odometry with geometry-guided loop-closure refinement leads to more accurate trajectories and higher-quality maps.

Positive margins in head and neck oncologic surgery require mapping specimen-side pathology findings to the patient resection bed. This is challenging because pathologists identify the positive margin on slices of the resected, deformed specimen, while surgeons must relocate the corresponding site on the resection bed using only verbal descriptions and no visual guidance. We present a marker-free augmented reality (AR) workflow for mapping a margin label from a three-dimensional specimen scan to the resection bed. The method combines contour-constrained deformation, residual alignment to a depth scan, surface-based fusion to a head-mounted display, and target projection onto the reconstructed bed. Bead-suture correspondences estimate specimen deformation, whereas patient-to-display fusion does not require external fiducial markers. Following formative experiments, five residents and surgeons performed cadaveric cheek and scalp re-resection tasks under verbal guidance, verbal guidance with specimen examination, and AR guidance. Deformation target errors were $7.63 \pm 3.74$ mm for the cheek and $3.72 \pm 1.02$ mm for the scalp; residual specimen-to-bed distances were $2.43 \pm 2.15$ mm and $2.19 \pm 1.06$ mm, respectively. Fusion error did not differ significantly between marker-free and marker-based methods on either cadaver; overall marker-free fusion error was $2.15 \pm 0.87$ mm. End-to-end margin localization error decreased from $21.40 \pm 3.84$ mm with verbal guidance and $16.09 \pm 4.30$ mm with specimen examination to $6.19 \pm 1.79$ mm with AR guidance ($p < 0.001$). Online fusion required $5.23 \pm 0.34$ s. These results demonstrate effective marker-free AR guidance for positive-margin localization and support more precise tumor resection.

Freehand 3-D ultrasound (US) imaging has attracted increasing attention owing to its intuitive volumetric visualization, ease of use, and low cost. However, accurate 3-D reconstruction critically depends on stable probe pose estimation, yet existing trackerless methods remain susceptible to accumulated pose errors, particularly over long scanning trajectories. To address this limitation, we propose a global-to-local pose estimation framework that exploits external camera observations for globally stable localization and B-mode US images for anatomy-aware local refinement. Specifically, the framework comprises a dual-camera branch that performs contextual feature aggregation across camera views and temporal observations to estimate a globally consistent probe trajectory, and a B-mode branch that performs anatomical feature aggregation from sequential US images to capture tissue-dependent local motion cues. A cross-modal fusion module subsequently integrates the contextual camera features and anatomical US features to predict pose residuals and refine the camera-derived estimates in the transformation space. Furthermore, a multi-scale pose loss constrains relative motion over multiple temporal horizons to suppress accumulated drift during extended scans. The proposed framework is validated on phantom and in vivo datasets. On two in-house datasets (FUSION-J and FUSION-L) collected using different machines, the proposed US + Dual-Cam model reduces average trajectory drift to 1.67 mm and 1.29 mm, representing improvement of 16.50% and 27.12%, respectively, over a strong dual-camera baseline, while substantially outperforming US-only pose estimation (>13 mm drift). In in vivo forearm arteries reconstruction, it achieves Hausdorff distances of 1.58 mm, demonstrating the effectiveness of the proposed method on real clinical scenarios.

Accurate geometric calibration is essential for fluoroscopy-guided spinal imaging, digitally reconstructed radiograph (DRR) generation, and 2D--3D vertebral registration. Although calibration quality is typically evaluated using reconstruction-based metrics such as reprojection error, its influence on projection-domain consistency remains poorly understood. This study presents a synthetic framework for evaluating how intrinsic calibration perturbations affect vertebral fluoroscopic projections and downstream registration performance. CT-derived vertebral models and controlled cone-beam imaging geometry were used to generate DRRs with both ground-truth and perturbed intrinsic calibration parameters while maintaining identical anatomy and acquisition pose. Projection-domain changes were quantified using anatomical landmark displacement, contour distance, silhouette overlap, image similarity, and landmark-based 2D--3D registration accuracy in anterior--posterior (AP) and lateral (LAT) views. Results show that even small intrinsic calibration perturbations produce measurable changes in vertebral projection geometry, contour morphology, landmark localization, and DRR appearance. Sensitivity is strongly view dependent, with LAT projections exhibiting substantially greater deformation and anatomical displacement than AP projections. These projection inconsistencies also degrade downstream 2D--3D registration, particularly rotational alignment accuracy. The findings demonstrate that projection-domain consistency complements conventional reconstruction-based calibration metrics and provides a practical framework for assessing calibration robustness. This approach may improve the reliability of DRR generation and fluoroscopy-guided vertebral registration in image-guided spinal applications.

Communication graph rigidity is a fundamental requirement in many multi robot formation control approaches. However, ensuring and maintaining a rigid communication topology becomes challenging in practice due to limited sensing ranges and dynamic operating conditions. This paper provides a method for achieving an inter robot collision free, rigid time varying communication graph, where communication links are established or broken according to limited sensing ranges, without assuming an initial rigid graph. In addition, the proposed approach guarantees the realization of a rigid graph for heterogeneous nonlinear multi robot systems. A computationally lean, distributed quadratic optimization-based controller is developed for a leader follower architecture, acquiring rigidity based on hierarchical second-order consensus among robots. Follower agents do not require global absolute positions of any agent, including their own. The proposed method is validated through both simulations and hardware experiments in a motion-capture environment, demonstrating reliable performance under the limited sensing capabilities of individual robots.

In many real-world systems, including articulated robots and biomechanical models, rotations are defined in joint space and naturally parameterized by Euler angles with bounded ranges. Yet regressing Euler angles remains challenging, as their discontinuities and singularities often destabilize training. In this work, we revisit Euler-angle regression and show that its effectiveness depends critically on the interaction between rotation representation, regression architecture, and domain constraints. We introduce a new framework that combines range-aware Euler modeling with Kolmogorov-Arnold Networks (KAN), which replace fixed node-wise activations with learnable univariate functions on edges. We further provide theoretical analysis indicating that bounded Euler ranges motivate a near-additive structure in the regression function, which favors the additive functional form of KAN, and we confirm this trend empirically. Extensive experiments on controlled rotation regression, object pose estimation, and robotic and human inverse kinematics demonstrate consistent improvements in accuracy, convergence, and efficiency. The code will be publicly available.

Multimodal CT-MRI registration is central to image-guided radiotherapy, surgical navigation, and diagnostic workflows, but most pipelines report only aggregate quality metrics without per-case reliability signals. We propose a reliability-aware framework that converts registration quality into Green/Yellow/Red risk categories using data-learned thresholds. CT images were registered to T1-weighted MRI using rigid and affine transformations on 90 paired slices from 18 patients across brain, abdominal, and neck anatomies. Reliability was assessed using Delta NMI, Delta SSIM, Dice overlap, registration stability, and inverse consistency error, combined into a single score R. Thresholds learned from training patients were applied unchanged to held-out test patients. Affine registration outperformed rigid registration on NMI and SSIM, yielding 44% Green classifications versus 33% for rigid. Reliability-filtered registrations improved the average alignment profile compared with unfiltered methods. Per-anatomy analysis showed substantial variation, with stronger reliability for abdominal registrations than brain registrations. Weight sensitivity analysis identified Dice overlap as the dominant reliability component. The proposed framework provides an interpretable quality-control layer for multimodal registration, while risk thresholds reflect statistical rather than clinical validation.

Real-time, drift-free UAV geo-localization is essential for autonomous missions in GNSS-denied environments. The pioneering system, PiLoT, achieves high precision via Neural Pixel-to-3D Registration, aligning UAV video streams with a single rendered reference view from 3D meshes. However, its reliance on heavy 3D meshes incurs massive storage overheads, complex map acquisition, and significant computational rendering costs, severely hindering deployment on embedded platforms. To address these bottlenecks, we propose PiLoT v2, a lightweight yet robust evolution that shifts the paradigm to direct pixel-to-orthogonal map registration for free-view UAV geo-localization. By leveraging True Digital Orthophoto Maps (TDOMs) and Digital Surface Models (DSMs) as the reference substrate, PiLoT v2 replaces GPU-intensive 3D rendering with a highly efficient, CPU-friendly map cropping operation. To bridge the severe geometric discrepancy between these 2.5D orthogonal crops and free-view oblique UAV imagery, we train a cross-view feature registration network using a novel, large-scale geometrically annotated dataset. Furthermore, we integrate onboard sensor prior--specifically gravity direction and single-point laser rang--directly into the pose optimization manifold to enhance robustness against cross-view visual degradation. Experimental results demonstrate that PiLoT v2 achieves performance comparable to, or even exceeding, its Pixel-to-3D predecessor, while offering drastically lower storage and computational costs.

Cross-modal image registration is essential for multi-sensor perception but remains fundamentally challenging due to severe non-linear radiometric discrepancies and geometric distortions. Existing deterministic matching methods lack uncertainty awareness, struggling to navigate the resulting highly non-convex optimization landscape and frequently accumulating errors in ambiguous regions. In this paper, we propose RBE-Flow, a novel framework that reformulates dense cross-modal flow estimation as a closed-loop recurrent Bayesian estimation problem on learned feature manifolds. Diverging from standard feed-forward regression, RBE-Flow establishes a robust self-correcting mechanism by deeply coupling feature-metric non-linear optimization with probabilistic state updates. Specifically, a Recurrent Manifold Optimization (RMO) block iteratively generates flow observations and their associated uncertainties, which are then optimally assimilated into the prior state via an Uncertainty-Adaptive Probabilistic Update (UAPU) using deterministic sigma-point projection. Crucially, the resulting calibrated posterior covariance is fed back to adaptively regularize the damping of subsequent optimization steps, allowing the system to modulate its convergence based on predictive confidence. To ensure stable probabilistic training, we introduce a hybrid supervision scheme featuring a geometry-aware rectified NLL loss that structurally prevents variance collapse. Extensive experiments on challenging OSdataset, WHU-OPT-SAR, and RoadScene benchmarks demonstrate that RBE-Flow consistently achieves state-of-the-art performance, outperforming existing methods by a significant margin, particularly under strict sub-pixel criteria. Project page: https://github.com/NEU-Liuxuecong/RBE-Flow

Medical image registration benefits significantly from deep learning, yet existing approaches often lack physical explainability and fine-grained deformation control. Motivated by Demons algorithms, we propose a novel DrivenMorph framework that bridges attention mechanisms with variational image registration by incorporating difference modeling as a physically inspired inductive bias. The resulting driving force, computed from local differences in the latent feature space, provides explicit semantic guidance throughout the registration process. It directly drives the registration process through a neural Demons layer that simulates force-displacement interactions to generate smooth and anatomically consistent deformation. Unlike previous methods, our approach not only integrates traditional registration principles with popular deep networks, providing an explainable and efficient solution for learning-based medical image registration, but also separates difference modeling from deformation, improving modularity and explainability. Extensive experiments on multiple 3D brain MRI datasets demonstrate superior performance over state of-the-art learning-based and optimization-based methods. Furthermore, visualizations and statistical analyses confirm that the learned driving force aligns closely with actual deformation patterns, supporting its explanatory value.

Full-field measurement techniques such as digital image correlation and infrared thermography are prevalent in experimental solid mechanics. Digital image correlation is used to analyze surface deformation, while infrared thermography quantifies surface temperature fields. However, sophisticated procedures are necessary to express both datasets in the same Lagrangian frame, especially when analyzing non-flat surfaces. In this study, we propose an external projection-based coupling that uses the pinhole camera model to relate two-dimensional temperature data measured by infrared thermography to three-dimensional point coordinates from stereocorrelation-based digital image correlation. Unlike existing multiview approaches, we utilize two independently calibrated industrial-grade systems and augment the experimental evaluation with the pinhole camera model. The projection matrix of the camera model is calibrated using a single image of a reference object. Through this projection, temperature fields are accurately represented at material points. Our method is particularly suited for, but not restricted to, curved surfaces and straightforward to embed in existing experimental protocols, as the image registration is kept as is. Additionally, we propose using radial basis functions as a global interpolation ansatz in both space and time to compute in-plane temperature gradients and even temperature rates on curved surfaces, thereby providing an extensive and information-rich full-field dataset.

We present MMD-Reg, a novel correspondence-free approach to point-cloud registration that is differentiable and has linear computational complexity in the number of points. We model registration as a nonlinear least-squares problem based on the Maximum Mean Discrepancy, approximated using random Fourier features. The resulting objective can be solved efficiently with standard methods such as Levenberg-Marquardt, and the solution is differentiable via the implicit function theorem. This allows MMD-Reg to be used as a differentiable optimization layer within end-to-end trainable models, supporting registration under challenging conditions such as poor initial alignment and partial overlap. We demonstrate this Neural MMD-Reg formulation by integrating the layer with a set transformer, training the resulting model in supervised and unsupervised settings, and comparing its performance against recent learning-based methods. We also evaluate standalone MMD-Reg, comparing its accuracy and scalability against widely used non-learning-based registration methods.

3D/2D registration serves as a cornerstone technique in surgical navigation. Traditional iterative optimization algorithms suffer from low efficiency and high failure rates in intraoperative settings. Deep learning-based methods reformulate registration from iterative optimization to a regression problem that maps image appearance features to spatial pose, typically achieving improved real-time performance and accuracy. However, such learnable methods are confined to memory-driven retrieval of specific pose features rather than understanding the task of image alignment itself, which limits their generalization in complex scenarios. We propose LayersReg, a pioneering regression paradigm that endows the model with 3D anatomical awareness and searches for the correct pose in a progressive, layer-by-layer manner. Inspired by the iterative pose-searching optimization criterion of classical registration, LayersReg searches for correlations between the moving and fixed images in feature space, capturing the trend of pixel flow and thereby converging iteratively toward the correct spatial pose transformation. We further design a coupling of node-wise regression with the progressive registration framework to enhance the model's perception of spatial pose changes. Experimental results demonstrate that under large offsets and multimodality conditions, LayersReg achieves high accuracy on both X-ray/CT registration (0.68°, 1.41 mm) and slice localization (0.73°, 1.55 mm) tasks, outperforming existing state-of-the-art methods while meeting the intraoperative demands for precision and real-time capability.