Digital Twins

The rapid proliferation of Internet of Medical Things (IoMT) devices introduces critical cybersecurity vulnerabilities in healthcare environments where resource-constrained medical devices operate under strict latency requirements and stringent data-privacy regulations. To address these challenges, this paper presents the Lightweight Digital Twin and Federated Reinforcement Learning (LDT-FRL) framework, a privacy-preserving defense architecture integrating four complementary mechanisms: a Temporal Attention Encoder (TAE) built on a GRU backbone with learned temporal self-attention for flow-level threat classification; lightweight LSTM-based Digital Twins trained on normal-class traffic to generate per-device anomaly scores that gate the TAE classifier through a learned sigmoid coupling; a Federated Proximal Policy Optimization (PPO) agent selecting among ALLOW, ISOLATE, and HONEYPOT_REDIRECT actions based on a seven-dimensional state; and an intelligent honeypot layer that converts redirected suspicious traffic into actionable threat intelligence. A federated aggregation strategy employing EMA-smoothed per-client validation losses as inverse-weighted FedAvg coefficients stabilizes global model updates under non-IID client distributions. Evaluated on CICDDoS 2019 and TON-IoT benchmarks, LDT-FRL achieves 99.66% and 99.95% test accuracy respectively, with macro-F1 scores of 0.9913 and 0.9995, converging 81% faster than the DTFL-CD baseline while attaining perfect F1=1.000 on the severely imbalanced MITM class. Explainability analysis via SHAP, LIME, Grad-CAM, and counterfactual methods confirms that the TAE focuses on semantically meaningful flow features, providing interpretable evidence for each defense decision.

The ocean plays a critical role in sustainable development, particularly in climate change mitigation. Among marine ecosystems, blue carbon ecosystems are recognized as important natural carbon sinks. In this context, this paper addresses precise seaweed classification for blue carbon quantification in Ocean Digital Twin initiatives. Conventional methods, including supervised learning (limited by data scarcity and domain gaps) and self-supervised learning (unable to assign class labels), struggle with underwater complexities and diverse seaweed species. To overcome this, we propose a novel two-stage seaweed segmentation technique. This technique first utilizes Supervised and Self-supervised Learning Model Propagation (SSL.Prop.), which leverages supervised learning for initial class information and approximate locations, guiding self-supervised learning for detailed, accurate segmentation. Subsequently, MaskFusion (MF) refines these results by merging instance-level masks for highly accurate segmentation. This integrated approach allows automatic class label assignment and mitigates domain gap effects. Specifically, instance segmentation estimates sparse point locations which then guide self-supervised learning for detailed region segmentation. Evaluated with underwater images from Yamaguchi Prefecture, our full proposed method (SSL.Prop.+MF) achieved a 0.082 mIoU improvement over USIS-SAM, demonstrating significant accuracy gains, particularly for small seaweed. This approach demonstrates strong potential for improving blue carbon quantification and marine ecosystem monitoring.

Industrial automation is being transformed by digitalization and the increasing use of cyber-physical systems. Modern production environments require greater adaptability, faster reconfiguration, and more intuitive human-machine interaction. However, traditional rule-based systems rely on fixed logic and cannot autonomously adapt to changing conditions. Consequently, current automation systems lack a systematic approach for integrating adaptive and generalizable reasoning capabilities for interpreting, planning, and executing user tasks across dynamic environments and heterogeneous components. This dissertation proposes a three-layer framework that integrates large language models (LLMs), digital twins, and automation systems into an autonomous system. Autonomy is defined as a design property assigned to system components and enabled through LLM-based reasoning to achieve adaptive, goal-oriented behavior. The Task-Process-Service-Resource (TPSR) model is introduced to transform user tasks into executable processes. Four LLM roles are identified: process orchestration, service matching, digital resource generation, and agent-as-a-service. Five peer-reviewed studies develop and refine these concepts using the design science research methodology. Case studies and prototypes demonstrate adaptive task planning, event-driven control, simulation-based parameterization, and digital model generation. Results show high task executability, command correctness, and content-generation accuracy while reducing manual effort. The framework enables the integration of LLM-based reasoning into industrial automation systems and improves adaptability and usability. Limitations include dependence on accurate digital representations, the computational demands of LLMs, and the need for human intervention in safety-critical situations.

UAV-based pavement inspection can reduce the cost and risk of road-surface monitoring, but real-world deployment remains difficult when traffic, pedestrians, and temporary occlusions affect defect visibility. This paper presents a Unity-based digital twin framework for traffic-aware UAV pavement monitoring in open-traffic conditions. The proposed environment integrates procedurally generated road defects, dynamic traffic agents, autonomous UAV navigation, and a multitask YOLOv8n perception module for detecting road defects, pedestrians, and vehicles while classifying road-defect subtypes. After synthetic-domain fine-tuning, the perception model achieved 0.959 mAP@0.5 and 0.940 macro F1-score on a held-out synthetic test set generated from the simulator. The digital twin was then used to evaluate hover-and-recheck, micro-repositioning, and skip-and-revisit recovery strategies across different traffic densities and flight altitudes. Results show that flight altitude strongly affects inspection coverage, while recovery strategies introduce different trade-offs between coverage, mission duration, energy consumption, and revisit behaviour. These findings demonstrate that digital twins can support the development and evaluation of traffic-aware UAV inspection strategies before real-world deployment. The full implementation and trained models are available at https://github.com/EdwinTSalcedo/RDMO-DigitalTwin.

Building personalized cardiac electrophysiology (EP) digital twins requires identifying the appropriate model structure for each patient, not merely fitting parameters. Traditional methods rely on experts to manually prescribe hybrid physics-neural architectures, which requires deep domain expertise and does not transfer across patients. Recent works have applied large language models (LLMs) to generate or act as hybrid models. However, despite their promising generalization capacity, these LLM-based methods lack the structural priors needed for stable cardiac simulations. Hence, we propose LEADS, a framework that formulates cardiac EP domain knowledge as a structured action space and utilizes an LLM agent to discover hybrid models. The agent follows an iterative reasoning-and-action loop to select, combine, and refine hybrid models, whilst gradient descent handles parameter fitting. The proposed LEADS designs every candidate model towards physically grounded, interpretable, and numerically stable, while allowing open-ended architectural discovery. We validate LEADS on synthetic data with three ground-truth reaction models and on real cardiac EP data, demonstrating that it outperforms both human-designed hybrid models and other LLM-based hybrid modeling.

Process twins provide real-time representations of entire production processes. By capturing how process steps interact, rather than monitoring a single machine in isolation as an asset-based digital twin does, they have the potential to drive efficiency gains across the whole process. However, developing a process twin is costly. It requires accurately modelling the entire production process: its process steps, the equipment and product-specific settings each step uses, and its process variations. The resulting model must then be bound to live operational data. We present FacProcessTwin, a system that leverages a large language model (LLM) to reduce this development time, building a process twin from a plant's process documentation and natural-language input from an operator. FacProcessTwin generates this complete process model and then automatically binds its process steps to live operational data. The generated model and its data bindings are rendered as an interactive process diagram through which manufacturing personnel can monitor and correct the system's autonomous decisions, such as resolving uncertainty at safety-critical binding steps. We evaluate FacProcessTwin through a real-world case study of an Australian food manufacturer, covering 16 production process flows that span chilled, frozen, and aseptic shelf-stable product categories and include process variations within the same product. The results show that FacProcessTwin generates these process models accurately (a mean F1 of 95.2% against ground truth) and builds each twin in roughly a sixth of the manual time. Its human-in-the-loop governance then keeps the safety-critical bindings correct: at ambiguous tags where a single-pass baseline silently mis-binds 75.0% of the time, FacProcessTwin defers to the operator and mis-binds none.

Clinical decision support AI systems (CDSASs) must adapt to evolving patient conditions in real-time while adhering to strict safety constraints. We present an online adaptive framework that integrates Treatment Effect (TE) estimation to quantify clinical benefits, a patient Digital Twin (DT) to simulate treatment trajectories, and Reinforcement Learning (RL) for sequential decision-making. The AI system is initially trained on historical medical records and operates in a continuous learning loop. To ensure safety, a rule-based module monitors vital signs and blocks contraindicated treatments. Cases with strong internal model disagreement are flagged for clinician review, simulated in our experiments via a pre-trained outcome model. We validate our framework using both a synthetic clinical simulator and a real-world ovarian cancer dataset from The Cancer Genome Atlas (TCGA). In both simulated and clinical settings, our method demonstrated superior effectiveness and stability in recommending treatments compared to standard computational baselines. Furthermore, the AI system maintains low latency and requires expert consultation for only a minority of cases in our experimental validation, demonstrating its potential as a safe, clinician-supervised tool for personalized medicine that continuously improves through practical use.

Text-to-video retrieval in operating rooms (OR) is an enabling technology for OR safety, as it allows stakeholders to retrieve and inspect recordings of specific events. However, because the most safety-critical events may not follow the common structure, to unlock its full potential text-to-video retrieval must be able to handle implicit queries that require reasoning to identify the right video (e.g., the step right before clipping). However, existing methods rely on global embeddings that cannot reason over such queries. We propose OR3, a text-to-video retrieval method that converts clips into action-driven digital twins (ActDTs), grouping concurrent subject-action-object triplets under non-overlapping temporal intervals. Moreover, rather than cross-modal matching through paired encoders, OR3 performs imagination-based retrieval where an LLM generates hypothetical ActDTs from queries. This enables intra-modal matching via a single encoder trained with ActDT-tailored hard negatives. Finally, evidence-grounded refinement revises imagined ActDTs based on discrepancies with top candidates to capture procedure-specific patterns. We construct a benchmark from MM-OR with 276 implicit queries across four reasoning categories over 386 clips from robotic knee procedures. OR3 achieves 57.6 R@1 and 77.3 R@5, outperforming the strongest baseline. These results demonstrate that OR3 enables fine-grained discrimination between visually similar OR video clips through temporal action reasoning.

Surgical video question answering requires multi-step reasoning across semantic, spatial, and temporal dimensions. Existing methods architecturally compress videos into discrete token representations and couple visual perception with reasoning. This approach fragments continuous spatial-temporal relationships and has been shown to restrict multi-step reasoning capabilities. We introduce a reinforcement learning (RL) framework that trains large language models (LLMs) to decouple perception from reasoning by operating over digital twin representations constructed from surgical foundation models. Additionally, we introduce hierarchical representations across frame, temporal window, and procedure levels with probabilistic uncertainty estimates. Finally, we propose a novel reward that combines format validation with accuracy assessment through clinical plausibility evaluation and uncertainty-aware calibration for training. To demonstrate the capabilities of this approach, we introduce REAL-Colon-Reason, a colonoscopic benchmark with 2000 question-answer pairs across three complexity levels. We achieve state-of-the-art performance on REAL-Colon-Reason and two existing surgical VideoQA benchmarks REAL-Colon-VQA and EndoVis18-VQA.

Enterprise behavioral simulation requires more than producing a plausible response. Many decisions depend on the shape of a population under a proposed action: which segments accept, defect, hesitate, or move into risk-sensitive states. This paper introduces Posterior Twins, a memory-grounded digital-twin approach that represents likely behavior as an updated distribution under a specific decision context. We evaluate a family of Twinning Labs behavioral-model operating points on a 226-example held-out behavioral-response benchmark and report both modal accuracy and Wasserstein-1 distance. The results show that modal accuracy and distributional fidelity identify different operating regimes. TL-Twin Alpha achieves the lowest observed Wasserstein-1 distance in the reported result set ($W_1 = 1.16$), while TL-Twin Delta and TL-Twin Gamma provide balanced operating points near the modal-accuracy frontier. The paper frames these results as a systems result: governed memory, behavioral model routing, scenario orchestration, distributional aggregation, and auditability are necessary for turning simulated behavior into reusable enterprise decision evidence.

Digital twin modeling, including control and data assimilation under model uncertainty, often faces an open-ended fidelity problem: adding variables, data streams, and time scales can indefinitely increase model complexity, ultimately producing systems that are difficult to maintain, validate, interpret, and use for stress or safety testing. As an alternative, one can seek parsimonious stochastic surrogate models built only on the variables needed to describe the relevant quantities of interest. We introduce a framework for discovering such variables from observational data by identifying which candidate inputs influence the full conditional law of a target quantity, rather than only its conditional mean. This distinction is essential in stochastic, coarse-grained, or partially observed systems, where dependencies may appear through changes in variability, tail behavior, multimodality, or uncertainty rather than through deterministic functional relationships. The framework couples conditional generative modeling, which learns the conditional distribution of the target given candidate inputs, with Gaussian-process-based analysis of variance (through kernel mode decomposition), which enables iterative pruning of non-influential inputs and interpretable structure discovery. In control settings, the resulting surrogate can be interpreted as a learned Markov decision process: the method identifies not only a transition model, but also the state, action, and memory variables needed to make the learned dynamics effectively Markovian. Across examples involving stochastic dynamical systems, missing variables, PDE control, reinforcement learning, and economic data, the discovered structures yield interpretable stochastic surrogates whose downstream performance is comparable to models trained on the full variable set.

Humans naturally understand object physics through everyday interactions, but faithfully predicting complex deformable dynamics, such as elastic materials and fabrics, remains a major challenge for computer vision and robotics. We present EgoPhys, a framework that constructs deformable physical digital twins from egocentric RGB-only video using generalizable priors. EgoPhys overcomes the limitations of existing methods to enable controllable deformable digital twin generation from egocentric videos by distilling per-object inverse-physics solutions into a compact codebook, enabling prediction of dense spring stiffness fields for unseen objects without per-spring test-time optimization. Trained with generalizable priors from diverse egocentric interactions, EgoPhys outperforms baselines in reconstruction, future prediction, and zero-shot generalization. To support training and evaluation, we curate an egocentric interaction dataset covering diverse deformable objects, scenes, and manipulation styles. We deploy EgoPhys on a real xArm6 robot, demonstrating that a digital twin initialized from a single egocentric human play video can serve as an internal world representation to aid in deformable-object planning, highlighting egocentric RGB observations as a scalable path toward real-to-sim pipelines.

Despite steady advances in flexible automation in sectors such as electronics and automotive manufacturing, apparel automation remains challenging because fabrics are deformable and difficult to manipulate with robots. This paper presents a deployment-oriented case study of a robotic sewing system for denim manufacturing, emphasizing the system-level integration required for practical adoption. At the engineering level, a digital thread module parses DXF production drawings into process parameters and executable robot trajectories, reducing manual programming effort and enabling rapid re-targeting across sewing operations. In parallel, a digital twin of the workcell is used during pre-deployment to validate reach and clearance, refine layout and sequencing, evaluate operator access, and assess cycle-time compatibility with upstream and downstream tasks, thereby reducing commissioning risk. At deployment, the system integrates a collaborative robot with conventional sewing equipment, welding, suction fixtures, and machine-level controllers through an interoperability layer. Runtime monitoring and verification, including seam monitoring, collision checking, and trajectory-level validation, improve robustness under environmental variability, while operator-facing training and guidance tools support setup, troubleshooting, and technology adoption. Two staged factory deployments on denim shorts, covering 2D pocket operations and 3D garment-shaping seams, show that digital-twin-based validation, digital-thread-driven task generation, interoperability, runtime verification, and operator training are important for scaling robotic apparel automation.

A digital twin (DT) of a patient-specific heart offers significant potential in personalized medicine. However, its rapid and dynamic adaptation to an individual's live data and its predictive capability after adaptation remains central challenges. We examine this challenge from its two building blocks: DT formulation where mechanistic and data-driven models show competing merits and limitations, and DT optimization strategies that are largely driven by a reconstruction objective leading to un-identifiable models. We address both bottlenecks via HAPI -- an AI framework for building hybrid, adaptive, and predictive DTs with three key enablers. First, HAPI constructs a physics-integrated gray-box model in which an interpretable mechanistic backbone is augmented by a neural component that models its residual to the observed data. Second, rather than attempting to pre-encode all possible variations in a static hybrid model, HAPI enables rapid on-the-fly adaptation of the hybrid model to few-shot live data, achieved by feedforward meta-learners realizing amortized inference of both mechanistic and neural parameters of the hybrid model trained with predictive objectives. Finally, we show that this adaptivity corresponds to the construction of a conditional generative model (i.e., the hybrid DT) that endows it with theoretical identifiability and thus strong performance in predictive scenarios. We demonstrate the proof-of-concept of HAPI in cardiac electrophysiology using a hybrid monodomain model with mechanistic reaction kinetics and neural graph diffusion. Across synthetic and real-data studies, we show that HAPI's mechanistic-neural hybridization and predictive adaptation are critical for obtaining identifiable DTs with strong predictive and out-of-distribution capabilities.

Optimization modeling is inherently hierarchical, requiring a precise sequence of symbolic commitments. Traditional learning-based automated optimization modeling methods improve modeling policies through large-scale annotated or curated training data, but are costly to adapt to new problem distributions. Meanwhile, one-shot generation remains brittle in hierarchical modeling, where early symbolic errors can propagate into invalid formulations. Test-time scaling offers a promising alternative by enabling structural exploration with additional instance-level computation; however, existing search-based methods typically rely on a fixed policy, causing repeated rollouts to inherit similar modeling biases and providing limited credit assignment for intermediate decisions. To address these limitations, we propose StarOR, a synergistic search-and-adaptation framework that couples MCTS with Test-Time Reinforcement Learning for optimization modeling. StarOR decomposes the modeling process into four stages and updates a transient LoRA adapter via GRPO at each non-terminal node. By using MCTS-generated siblings as local comparison sets, StarOR transforms search-time exploration into instance-specific policy refinement. Moreover, an unsupervised multi-faceted reward system provides fine-grained feedback for intermediate formulation decisions without ground-truth labels. Experiments across five optimization benchmarks show that StarOR achieves state-of-the-art performance even with a 4B backbone, outperforming existing methods and the frontier LLMs.

Business intelligence (BI) increasingly combines dashboard interaction with LLM-based assistance, but these two modes often fall out of sync during multi-step analysis. As users switch between direct dashboard manipulation and natural-language queries, it becomes difficult to preserve a consistent analytical state across filters, hierarchies, metrics, and chart context. We present TwinBI, an agentic digital-twin framework that couples an LLM-based agent system with an executable BI dashboard state. TwinBI unifies conversational interaction, dashboard manipulation, semantic grounding, and provenance tracking through a shared analytical state reconstructed from a unified interaction log. It also exposes artifacts such as schema views, SQL, logs, and an /insights command for state-grounded analytical summaries. We evaluate TwinBI in two complementary ways. In a controlled A/B benchmark with the same backbone agent, TwinBI improves exact-match accuracy from 43.3% to 63.3%, partial-credit accuracy from 48.3% to 70.8%, and substantially reduces timeout rate from 40.0% to 10.0% relative to Dashboard alone. In a usability study, participants benefited from the integrated dashboard-and-chat workflow, with high task accuracy, moderate workload, and favorable ratings for state-aware interaction mechanisms. These results suggest that TwinBI improves both agent-level analytical reliability and user-facing analytical support by turning visible dashboard state into richer actionable context. Our dataset and source code are available at: https://github.com/simonjisu/TwinBI

Building patient-specific cardiac models sits at the heart of precision cardiology, yet getting those models into clinical use keeps running into the same wall: mesh generation is slow, messy, and frustrating. The standard workflow -- segmenting the image, running Marching Cubes, and then manually cleaning up the result -- is time-consuming, inconsistent across operators, and demands specialist knowledge most clinical teams do not have. We take a fundamentally different approach. Instead of treating segmentation and mesh generation as two separate problems, we train a single end-to-end network that goes directly from a raw 3D medical image to a smooth, simulation-ready cardiac surface mesh. The core is a 3D Swin Transformer encoder-decoder that extracts volumetric features from CT or MRI volumes, paired with a Graph Attention Network (GAT) head that iteratively deforms a template mesh to fit the patient's cardiac boundary. We tested on the MM-WHS 2017 benchmark using both CT and MRI. Segmentation scores were competitive (Dice of 0.84 on CT, 0.83 on MRI), but the primary focus is mesh quality: mean Chamfer distance of 1.8 mm, with 95th-percentile surface distance below 5 mm. Every mesh is produced in a single forward pass -- no Marching Cubes, no smoothing filters, no manual cleanup. We argue that for cardiac digital twin pipelines, geometric fidelity and topological correctness matter more than pixel-level Dice scores. By removing the post-processing bottleneck, this approach makes patient-specific cardiac simulation substantially more accessible for clinical use.

Health digital twins (HDTs) promise patient-specific modeling and decision support but current approaches remain structurally fragmented: monolithic models that address a single organ or task lack cross-scale fidelity, while system-level twins lack generalizable architectural frameworks. We propose OmniBioTwin, a System-of-Twinned-Systems (SoTS) framework that organizes HDTs as modular computational entities coupled through explicit interaction operators within a multi-layer network architecture. The framework comprises seven coordinated layers - spanning data integration, autonomous twin modeling, cross-scale coupling, temporal synchronization, and human-in-the-loop decision support. We demonstrate OmniBioTwin by instantiating a multiscale twin for glucagon-like peptide-1 (GLP-1) signaling pathways in Alzheimer's disease, illustrating how molecular, cellular, and organ-level twins can be composed and coupled within a unified system.

Alzheimer's disease (AD) progression is highly heterogeneous and is typically observed through sparse and irregular longitudinal data, posing challenges for prediction and personalised monitoring. Existing machine learning approaches have improved AD prediction using multimodal data, yet often focus on static classification or cohort-level risk estimation, providing limited support for subject-specific modelling and uncertainty-aware reasoning. To address these limitations, we present a personalised digital twin framework for AD prediction and scenario-based analysis using multimodal longitudinal data. The proposed approach integrates complementary modelling strategies to capture clinical transitions and temporal dependencies across visits. Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), including cognitive assessments, clinical variables, and MRI-derived phenotypes, the framework predicts cognitive status and diagnostic categories while quantifying predictive uncertainty and enabling patient-specific what-if trajectory analysis. Evaluation on leak-free subject-level splits demonstrates strong performance in score forecasting and diagnosis classification. In this sparse and irregular ADNI setting, transition-based modelling of adjacent visits achieved higher predictive accuracy than the sequence-based branch, suggesting that local transition modelling may be more data-efficient. While sequence models remain valuable for uncertainty-aware trajectory forecasting, local transition modelling offers a more data-efficient and robust predictive strategy. These findings highlight the importance of aligning temporal modelling strategies with clinical data structure and suggest that transition-based digital twin formulations may provide a practical and interpretable approach for personalised disease forecasting in neurodegenerative disorders.

Flexible robotic automation requires systems that interpret operator intent, verify physical feasibility, and recover from execution failures across both the planning and execution stages. This paper proposes an agentic neuro-symbolic framework for human-in-the-loop industrial robotics, in which LLMs are used for tasks that require language understanding or contextual reasoning, while all verification, sequencing, and execution remain deterministic. The framework adapts the Planner-Generator-Evaluator (PGE) harness pattern from software engineering into a Specifier-Designer-Inspector (SDI) architecture for industrial robotics, combined with LangGraph-based dynamic routing for failure recovery. A two-tier recovery mechanism addresses structure-level replanning through context-aware orchestration and execution-level geometric failures through deterministic recovery skills. A Unity3D digital twin supports human inspection, modification, and re-verification prior to physical execution. Evaluated on natural-language commands across multiple difficulty levels against ten baselines, the proposed method achieves the highest task success. Ablation results confirm that structured command expansion, symbolic verification, selective LLM routing, and recovery skills are each individually necessary.

Digital twins (DTs) allow the digitalization of road infrastructure inspection, though this is hindered by limited annotated data. This work exploits the relational nature of continuous asset condition monitoring to reformulate image-based defect detection as image difference classification (IDC) to reduce data reliance. This was evaluated in a case study on low-resource traffic sign inspection with different IDC classifiers using a newly-curated, high quality dataset. Results indicate that the instruction-based classifier outperforms encoder-based ones and gains from comparison with reference images. This shows that IDC can be an effective task modeling for tackling data constraints in infrastructure inspection and DT asset condition updating.

Theoretical heterogeneous catalysis promises rapid catalyst discovery, yet computational and machine-learning predictions often deviate from experiment and stay confined to narrow material families, for want of a faithful, condition-aware catalytic simulator. We present CatDT (Catalysis Digital Twin), a self-evolving multi-agent system that builds an autonomous digital twin of a working catalyst, unifying gas-solid and liquid-solid modeling. From only a bulk crystal and a natural-language reaction description, eight specialized agents and 27 scientific tools predict stable facets, reconstruct working surfaces, enumerate and rank reaction pathways, locate transition states, and compute kinetics in 5-30 min on a single GPU. Two innovations address the hardest steps: UniMech finds dominant pathways for novel materials at over $10^3\times$ lower cost than exhaustive enumeration by fusing agent-guided proposals with energy-cached graph search, and a memory-augmented reinforcement loop raises barrier-calculation success from 41% to 84% across 600 catalytic surfaces. Across seven gas-solid benchmarks -- stepped metals, single-atom catalysts, ordered intermetallics, vacancy-rich 2D sulfides and carbides, and a strong-metal--support-interaction (SMSI) interface -- every CatDT prediction lies within 0.5-2 times experiment over four orders of magnitude. For propane dehydrogenation, CatDT independently discovers non-precious candidates rivaling the Pt-based industrial benchmark, with a proposed Ni@ZrO$_2$ SMSI overlayer reaching a simulated TOF of $1.63~\text{s}^{-1}$ at $\sim$100% selectivity. More broadly, the decisive factor for a faithful catalyst digital twin -- or any multi-stage scientific simulator -- is not raw LLM capability but the engineered harness around it: deterministic tools, persistent memory, and verified self-improvement that compound across models, tools, and runs.

LLM-based digital twins promise to scale and accelerate market research, but most published twins are either coarse persona bots conditioned on a few demographic questions or detailed individual-level twins built on purpose-collected surveys and interview transcripts. Neither setup speaks to the operationally most relevant case for marketing practice: building detailed individual twins from the pre-existing heterogeneous panel data that firms already accumulate through CRM systems, loyalty programs, and repeat surveys. We construct detailed individual-level twins from the German Socio-Economic Panel (SOEP) and evaluate them across a $3 \times 5 \times 2 \times 2$ construction-method grid that covers three open-weights LLMs, five cumulative information depths ranked by normalized Shannon entropy, two embedding methods, and two reasoning modes, scoring over 2.1 million twin responses on 500 participants and 183 held-out questions. Twin quality rises with information depth but with diminishing returns past the 75 percent entropy quartile, which acts as a cost-efficient Pareto point relative to the best-performing 100 percent cells. Switching the embedding from a narrative persona summary to a raw dialog history of past responses raises hold-out accuracy in every model-by-reasoning cell at the 100 percent depth, while an explicit thinking mode raises rank-order correlation without moving accuracy. Best-cell accuracy reaches 78.8 percent and Fisher-$z$ correlation reaches $r = 0.590$ on the SOEP held-out evaluation set. The findings suggest that twin-based market research is no longer gated by data design, but by item volume, model selection, and a small set of construction-level decisions that this paper now maps.

Alternatives to soil-based horticulture, such as hydroponics, have been developed to respond to food distribution concerns for dense urban centers. A new system was developed to track an individual lettuce plant's growth in a hydroponic environment, utilizing streams of measured information and available models to continuously update the growth trajectory estimates for a plant. These "digital twin" models were integrated into an operating hydroponic greenhouse, with custom horticultural and sensor hardware to grow and measure relevant information. To aid in updating model parameters, plant yield was continuously measured with a custom neural network, using RGB-D images of the plants as an input. The network, trained on a collected dataset of 1300 images, was able to estimate mass within 1.5 g of the ground-truth value. After integration into the custom system, digital twin growth projections could approximate future yield between one and four days in the future, maintaining around a 2 g forecasting error.

The evolution toward 6G wireless networks envisions a seamlessly intelligent, Open-RAN-enabled architecture where unmanned aerial vehicles (UAVs) play a pivotal role in extending coverage, enhancing resilience, and ensuring reliable connectivity for ground users deployment. However, efficiently managing spectrum and resources in such highly dynamic UAV-assisted environments remains a major challenge due to nonlinear system interactions, mobility-induced topology variations, and stringent latency and energy constraints. To address these challenges, we propose a digital twin (DT)-assisted adaptive deep reinforcement learning (DRL) framework that enables intelligent spectrum sharing and resource allocation across distributed ground users. The complex optimization problem is decomposed into UAV trajectory optimization using particle swarm optimization (PSO) and dynamic spectrum-power-association management via multi-agent DRL (MADRL). This hybrid DT-driven approach empowers intelligent, context-aware decision-making and adaptive coordination among UAVs. Extensive simulations demonstrate significant gains in spectral efficiency, data rates, and energy utilization, showcasing a transformative path toward self-evolving, autonomous 6G UAV and ground users (GUs) connectivity.

Conditioned Sequence Models (CSMs) learn policies by treating return-to-go (RTG) as a control signal. However, existing CSMs often treat the RTGs as simple numerical inputs rather than aligning them with the performance of their policies. In this paper, we propose Q-ALIGN DT, a framework that enforces this alignment by ensuring the $Q$-value of the output policy is consistent with the input RTG. By leveraging a $Q$ function to provide dense guidance to CSMs and further fine-tuning it using an RTG-perturbation technique with the CSM, our method ensures that higher RTGs are consistently mapped to trajectories with higher expected returns. Theoretically, we show that Q-ALIGN DT can efficiently learn the desired policy and output a near-optimal one when the RTG is sufficiently high. Empirically, we demonstrate through extensive experiments that Q-ALIGN DT achieves superior controllability and performance across the D4RL benchmark. Remarkably, our model effectively learns a structured family of policies that maintains precise alignment and generalizes to tasks like velocity-tracking where prior methods fail.

Optical tweezers (OT) provide piconewton-scale manipulation for delicate biomedical tasks, where visuo-haptic feedback can improve operator awareness by conveying interaction-force cues and trap-stability information. However, visuo-haptic teleoperation frameworks for complex-shaped optical microrobots remain underdeveloped, particularly in multi-trap manipulation scenarios. This paper presents a digital twin framework for virtual visuo-haptic teleoperation of complex-shaped OT-driven microrobots. The framework integrates a digital twin environment, image-based pose and depth estimation, microrobot motion simulation, and model-based haptic rendering within a Robot Operating System (ROS)-connected bimanual teleoperation system. For force modeling, we combine a Multi-Sphere Distributed Manipulation (MSDM) model with optical-force estimation from the Optical Tweezers Toolbox, enabling simulator-driven visuo-haptic feedback. The framework reproduces representative microrobot motion trends and provides haptic force rendering that is numerically consistent with the fitted optical-force model. In simulated cell-delivery tasks, haptic feedback reduced the standard deviations of the contact-force metric and the microrobot-to-trap-center distance metric by 53.2% and 55.2%, respectively, and improved task success from 30% to 80%. These results demonstrate the framework's effectiveness for evaluating visuo-haptic teleoperation strategies for complex-shaped optical microrobots.

High-fidelity computational fluid dynamics (CFD) is widely used for thermal-fluid design, but repeated CFD solves remain expensive for design optimization, uncertainty analysis, and digital-twin workflows. Recently, our team has demonstrated that a proper orthogonal decomposition and neural-network (POD-NN) surrogate can predict two-dimensional thermal fields in an electronics-cooling cold plate with large inference speedups while preserving physically interpretable modal structure. Reproducing and extending such workflows, however, typically requires custom scripts for parameter sampling, Fluent automation, data extraction, reduced-order model construction, neural-network training, validation, and prediction. This paper introduces CFDTwin, an open-source Python package and optional desktop graphical user interface (GUI) that packages these steps into a reusable workflow for ANSYS Fluent simulations. CFDTwin allows users to define simulation inputs and output quantities, generate design-of-experiments samples, run and resume Fluent batch simulations, train POD-NN surrogate models for scalar, surface-field, and cell-zone outputs, inspect validation metrics, and evaluate trained models at new design points without re-running Fluent. The same workflow is exposed through a scriptable Python API and a GUI, supporting reproducible studies, user-facing model validation, and automated design exploration. CFDTwin extends the prior POD-NN modeling study from a case-specific research implementation to a reusable research-software platform for CFD surrogate modeling and digital-twin development.

Wireless digital twins require repeated synchronization between a time-evolving physical scene and its digital counterpart under limited and time-varying communication resources. For perception-centric twins, pixel-domain transmission or uniformly protected bitstreams can be mismatched to the semantic state consumed by twin-side applications. This paper proposes TWIST, a closed-loop token synchronization framework for application-aware wireless digital twins. TWIST represents each physical observation as a token and synchronizes this state over a wireless link, rather than optimizing visual reconstruction. Token positions are grouped by task relevance and protected through mode-conditioned unequal error protection under low-, medium-, and high-synchronization modes. At the twin side, decoding confidence converts unreliable hard token decisions into erasures, which are restored by a completion model before updating the semantic twin state. The recovered state supports traffic-state inference and generates compact feedback statistics, including channel quality, receiver uncertainty, semantic drift, and application priority, for subsequent mode adaptation. Experiments on a dynamic road-scene digital-twin scenario show that TWIST improves traffic-state inference and semantic twin-state synchronization compared with fixed-mode and channel-only adaptation strategies, while reducing the average synchronization cost relative to always-high transmission.

Generating complete digital twins from videos requires precise camera control, global scene coverage, and strict spatial-temporal consistency constraints that remain challenging for perspective video generators due to their limited field of view (FoV). Their narrow FoV forces long or multi-view trajectories, amplifying cross-view inconsistency and temporal drift. We argue that 360° video generation offers a natural solution: panoramic coverage simplifies trajectory design and provides a strong global context for maintaining coherence. We introduce Pantheon360: Taming Digital Twin Generation via 3D-Aware 360° Video Diffusion, a controllable 360° video generation framework that synthesizes high-fidelity videos from sparse 360° inputs. The key idea is an explicit 3D Cache, reconstructed from the input, which serves as a geometric scaffold for any user-defined camera path. This allows the diffusion model to focus on photorealistic texture refinement while the 3D Cache enforces global geometric consistency. Experiments show that Pantheon360 achieves superior visual quality and unmatched geometric coherence, enabling reliable and flexible 360° scene generation for downstream simulation and digital-twin applications.

Comprehensive and efficient validation of connected and automated vehicles (CAVs) is critical prior to real-world deployment. While simulation-based testing offers scalability, existing approaches often lack seamless integration with real vehicles and field data, limiting their fidelity in capturing dynamic, real-world interactions. To bridge this gap, this paper proposes a novel real-time hybrid digital twin platform. Its core innovation lies in the tight coupling of a high-fidelity CARLA-SUMO co-simulation with a physical test site and vehicle via a low-latency Vehicle-to-Everything (V2X) communication link. A custom-developed middleware serves as the critical bridge, synchronizing a real CAV's kinematic state as a shadow vehicle in the simulation and translating virtual control commands into chassis-actuating Controller Area Network (CAN) messages for closed-loop control. Detailed implementation includes using photogrammetry for full-scale asset reconstruction and a cloud-edge collaborative architecture for scalable, multi-user operation. Experimental results demonstrate stable synchronization and effective closed-loop control with low latency, confirming the platform's practicality for multi-scenario CAV verification.

We propose a framework for predicting the effects of mobility introduction measures using a human-flow digital twin. This digital twin incorporates a multi-agent simulator that can represent how visitors choose destinations depending on factors such as their current location and the attractiveness of spots. We extract data on how visitors selected destinations with respect to measured pre-intervention human-flow data, inter-spot distances, spot attractiveness, and travel volumes, and use these data to train each agent's decision model of this simulator. The trained decision model is a function that takes a visitor's current state and surrounding environmental information as input and outputs which spot the visitor will move toward next. By expressing mobility introduction measures as changes to inter-point distances or to spot attractiveness, the framework can reproduce human flows with mobility introduction in the multi-agent simulator and thereby quantify effects such as changes in visitor counts and circulation. We evaluated the proposed method using human-flow data measured with and without introducing mobility within Wakayama Castle Park in Japan. When reproducing flows with mobility introduction using a multi-layer perceptron decision model, the cosine similarity of the spatial population distribution exceeded 0.7, confirming that the approach can replicate the flow changes caused by the mobility introduction.

Digital twins (DTs) rely on continuous synchronization between physical systems and their virtual counterparts through online parameter estimation under uncertainty. In many practical settings, however, this task is challenged by low observability, weak excitation, nonlinear dynamics, and noisy or biased measurements. In this work, we develop a new mathematical framework that integrates Weighted Flow Matching (WFM) generative modeling with physics-informed nonlinear filtering to enhance parameter estimation in DTs. WFM relies on dynamic reweighting of training samples, which guides the generative model toward parameter regimes most informative of the evolving system state. This generative component is tightly coupled with a physics-informed filtering architecture based on the Unscented Kalman Filter (UKF), yielding a unified DT framework that combines data-driven probability transport with physically consistent state and parameter estimation. The effectiveness of the new integrated framework is demonstrated within a spacecraft DT architecture, where stable moment of inertia estimation is achieved under uncertain and noisy sensing, with significant performance improvements over established approaches such as Extended Kalman Filtering (EKF) and Ensemble Kalman Filtering (EnKF). These results highlight the potential of weighted generative modeling as a core mechanism for real-time DT synchronization in operational and mission-critical systems.

Semantic communication has emerged as a promising paradigm for enabling goal-oriented networking. However, most existing semantic communication solutions are tailored to one-shot tasks and optimize instantaneous performance. Hence, they cannot be used to support closed-loop dynamic systems with physical artificial intelligence (AI), in which the transmitted semantics affect not only the current inference outcome but also future control actions, state evolution, and ultimately long-horizon task performance. To address this gap, this paper investigates goal-oriented semantic communications for physical AI systems with closed-loop sensing-communication-inference-control. In particular, the problem of semantic communications is formulated as a long-term return-per-bit maximization under wireless bit-budget constraints while capturing both control efficiency and communication efficiency. To solve this problem, a novel causal information value (CIV) metric is introduced to evaluate the marginal contribution of each semantic token to the expected long-term return by transmission interventions. Then, a world-model-enabled causal digital twin (WM-CDT) framework is proposed to capture the dynamics of closed-loop physical AI systems and enable counterfactual reasoning for long-horizon imagined rollouts. Based on these imagined rollouts, an actor-critic policy is trained for long-horizon agent control with high data efficiency, while the semantic token selector is trained through CIV-per-bit evaluation. Extensive simulations on an AirSim-Sionna-based unmanned aerial vehicle (UAV) navigation simulator show that the proposed WM-CDT framework achieves significant improvement in return-per-kbit and navigation success rate compared to existing reinforcement learning solutions.

AI-driven flood digital twins demand fast hydrodynamic surrogates for ensemble forecasting and observation assimilation. Yet even GPU-accelerated two-dimensional shallow water equation (SWE) solvers still require $\sim 55$ minutes per $96$-hour run on a $\sim 4.2$-million-active-cell metropolitan basin (the DesPlaines River basin at $30\,\mathrm{m}$ resolution), making such workloads prohibitive at native resolution. We present the Conditional Latent Dynamics Network (CLDNet): a low-dimensional latent neural ODE driven by rainfall, paired with a coordinate-based decoder conditioned on static terrain (elevation, slope, Manning roughness) that reconstructs depth and discharge at arbitrary query points. Pointwise decoding decouples memory from grid size and handles irregular watersheds natively, enabling metropolitan-scale training on a single compute node and direct queries at exact gauge coordinates without raster snapping. We evaluate CLDNet on a synthetic $250{,}000$-cell Texas benchmark and on a new DesPlaines case study of $114$ real-rainfall StageIV storms whose reference simulator we validate against United States Geological Survey (USGS) gauges at the April2013 flood-of-record (Nash--Sutcliffe efficiency $0.57$--$0.94$ on mean-recentered water-surface elevation). CLDNet roughly halves the relative root-mean-squared error of an unconditional baseline, outperforms regular-grid VAE--ConvLSTM and FNO baselines on the Texas benchmark (both presuppose a Cartesian grid and do not apply to the irregular Des~Plaines watershed), reaches a critical success index of $\approx 86\%$ at the $0.5\,\mathrm{m}$ inundation threshold, and produces a full $96$-hour basin-wide forecast in $\sim 29$ seconds -- a $\sim 115\times$ speedup.

The Industry Foundation Classes (IFC) standard is central to building data exchange across the lifecycle, from design and construction to facility management and Digital Twin integration. In operational settings, stakeholders increasingly require access to building information without specialist knowledge of IFC's complex, deeply nested schema, motivating natural language interfaces. Existing LLM-based querying approaches typically rely on a single data representation, which is not equally suited to attribute retrieval and spatial reasoning. We present IfcLLM, a framework that combines complementary relational and graph representations, routing each query type to the more suitable backend. An LLM agent integrates both through iterative retry-and-refine reasoning, recovering from failures without user input. Evaluated across three IFC models on 30 query scenarios, our implementation achieves first-attempt accuracy between 93.3% and 100%, with all failed queries resolved via a fallback LLM. Built on an open-weight LLM, it supports local deployment in data-sensitive AEC settings.

Single-arm trials are an important study design for evaluating drug efficacy and safety without enrolling patients into a control arm. Although they do not provide the gold-standard evidence of randomized controlled trials, they are increasingly used in clinical development as they offer an efficient, ethical, and practical alternative. A wide variety of approaches can be used to construct control comparators and estimate treatment effects, from fixed comparators informed by clinical knowledge to data-based and model-based patient-level comparators, also known as synthetic controls. Powerful and flexible machine learning models can allow outcome-model-based synthetic controls to overcome key limitations of direct data-based approaches, yield more robust estimates of treatment effects, and provide a principled way to incorporate corrections or encode additional assumptions when external data are not directly comparable. In this work, we argue that outcome-model-based synthetic control arms are an important tool for single-arm trials. We focus on digital twins, personalized predictions of disease progression generated from machine learning models trained on historical datasets, which naturally leverage these flexible approaches. We review doubly robust estimators, present power and sample size formulas, and discuss trade-offs in selecting historical data for training and analysis. We also outline practical considerations for deploying digital twins within the framework of recent FDA draft guidance on the use of artificial intelligence in drug development. Finally, we reanalyze data from trials in amyotrophic lateral sclerosis and Huntington's disease to demonstrate the proposed methods.

Digital twins (DTs) for urban transportation systems have gained increasing attention; however, their systematic evaluation in safety-critical scenarios remains limited. This paper presents a multi-pedestrian safety warning system at urban intersections enabled by a tightly coupled physical-digital twin framework. Built upon the COSMOS city-scale wireless testbed in New York City, the proposed system integrates camera and ultra-wideband (UWB), edge-cloud computing, predictive trajectory modeling, and MQTT-based communication to deliver real-time safety alerts to vulnerable road users (VRUs). The system is evaluated through both field deployment and virtual reality (VR) experiments. Results demonstrate high warning generation accuracy, localization accuracy, efficient end-to-end latency under different model configurations, and significant reductions in user response time when warnings are issued. The proposed DT framework provides a scalable, modular, and generalizable solution for real-time multi-pedestrian safety enhancement at complex urban intersections.

This paper presents a proof-of-concept digital twin framework for simulation-driven diabetes modeling using benchmark clinical data, synthetic temporal augmentation, and illustrative continuous glucose monitoring (CGM) analysis. Unlike traditional predictive models, the framework focuses on generating interpretable simulated trajectories rather than clinically validated outcomes. Evaluation is conducted using a public dataset combined with controlled synthetic scenarios to illustrate temporal behavior and intervention effects. Results illustrate the feasibility of integrating prediction with counterfactual simulation for decision-aware analysis. This work does not claim clinical readiness but provides a foundation for future research on simulation-driven digital twin systems in healthcare.

Despite the central role of sensor-derived measurements such as imaging traits and plasma biomarkers in biomedical research and clinical practice, existing generative models for disease prediction largely depend on event-level representations from hospital and registry data. Given the multi-factorial nature of human disease, the absence of explicit modeling of social determinants of health (SDoH), even in the limited form of ICD-coded proxies (chapters Z and V--Y in ICD-10), limits the capacity for personalized disease modeling and clinical decision support. To address this limitation, we propose a generative model with ICD-coded proxies of SDoH for \textit{in silico} modeling of disease reasoning, a conditioned latent diffusion framework that establishes the connection between multi-organ sensor data with tokenized healthcare events. Specifically, we introduce a novel geometric diffusion model to characterize the temporal evolution of complex data representation such as brain networks (region-to-region connectivity encoded in a graph), in parallel with diffusion models for tabular data from other organ systems. Together, we integrate the generative model with digitalized SDoH proxies (coined \modelname{}) for simulated intervention and reasoning of future disease trajectories. We conduct extensive experiments on the UK Biobank (UKB) dataset, which contains organ-specific imaging traits, including brain (44,834), heart (23,987), liver (28,722), and kidney (32,155), along with nearly 500k medical history sequences (age range: 25$\sim$89 years). Our \modelname{} achieves significant improvements over state-of-the-art human disease autoregressive models and imaging trait generative baselines.

Machine learning classifiers in dynamic environments face concept drift -- changes in the data-generating process that degrade performance. Conventional evaluation via static test sets or noise perturbations fails to preserve causal dependencies in tabular data, often producing causally invalid assessments. Post-hoc tools like SHAP and LIME offer correlational insights that may not reflect the causal mechanisms driving model failure. We propose a framework that complements existing drift detection by leveraging Structural Causal Models as "Digital Twins" of data-generating processes, enabling precise causal interventions while preserving structural dependencies. Our technique, Causal Parametric Drift Simulation, stress-tests classifiers to identify vulnerabilities before deployment. Experiments on the Open Sourcing Mental Illness (OSMH) dataset demonstrate that this approach exposes latent vulnerabilities invisible to standard statistical monitors.

Physics-based digital twins aim to predict the dynamics of real-world objects under interaction, enabling real-to-sim-to-real applications in robotics. Current approaches reconstruct such twins as explicit physical models (such as spring-mass systems) to predict the dynamics, but the resulting models often inherit the resolution of the visual reconstruction rather than being reduced to the physical complexity required to reproduce task-relevant dynamics. This mismatch introduces redundant topology, making repeated forward-dynamics rollouts unnecessarily expensive. To address this challenge, we present PhySPRING, an fully differentiable GNN-based method to reduce complexity in spring--mass digital twins. PhySPRING jointly learns a hierarchy of coarsened graph topologies and their mechanical parameters from observations. At each reduction level, PhySPRING merges nodes with similar learned dynamic responses to optimize the topology, while maintaining every reduced layer as an explicit spring--mass system. On the PhysTwin benchmark, PhySPRING improves dense reconstruction and prediction accuracy over PhysTwin, while reduced models retain stable physical and visual fidelity with up to a 2.30 times speed-up. We further demonstrate the effectiveness of PhySPRING in a Real2Sim robot policy-evaluation pipeline, where the reduced models are substituted zero-shot into ACT and $π_0$ evaluations, maintaining comparable manipulation success rates across downsampling levels while improving action-sampling effectiveness. Together, PhySPRING enables efficient and structure-preserving spring--mass reduction without sacrificing fidelity or robotic utility.

Bayesian model calibration is central to digital twins and computer experiments, as it aligns model outputs with field observations by estimating calibration parameters and correcting systematic model bias. Classical Bayesian calibration introduces latent parameters and a discrepancy function to model bias, but suffers from parameter--discrepancy confounding and is typically formulated as an offline procedure under a stationary data-generating assumption. These limitations are restrictive in modern digital twin applications, where systems evolve over time and may exhibit gradual drift and abrupt regime shifts. While data assimilation methods enable sequential updates, they generally do not explicitly model systematic bias and are less effective under abrupt changes. We propose Bayesian Recursive Projected Calibration (BRPC), an online Bayesian calibration framework for streaming data under simulator mismatch and nonstationarity. BRPC extends projected calibration to the online setting by separating a discrepancy-free particle update for calibration parameters from a conditional Gaussian process update for discrepancy, preserving identifiability while enabling bias-aware adaptation under gradual system evolution. To handle abrupt changes, BRPC is integrated with restart mechanisms that detect regime shifts and reset the calibration process. We establish theoretical guarantees for both components, including tracking performance under gradual evolution and false-alarm and detection behavior for restart mechanisms. Empirical studies on synthetic and plant-simulation benchmarks show that BRPC improves calibration accuracy under gradual changes, while restart-augmented BRPC further improves robustness and predictive performance under abrupt regime shifts compared to sliding-window Bayesian calibration and data assimilation baselines.

Real-time supervisory control of thermal energy distribution systems requires digital twins that are accurate, interpretable, and uncertainty-aware, yet remain data and computationally efficient. High-fidelity simulations alone are costly, while purely data-driven surrogates often lack robustness. To address these challenges, this work proposes an active learning (AL) framework that couples system-level Modelica simulations with four simpler physics-informed and data-driven surrogate modeling approaches: deterministic Sparse Identification of Nonlinear Dynamics with Control (SINDyC), its probabilistic multivariate-Gaussian extension (MvG-SINDyC), feedforward neural network (FNN), and gated recurrent unit (GRU) network. Tailored to each surrogate, model-specific AL query strategies are employed, including Mahalanobis-distance sampling in coefficient space for MvG-SINDyC and error-based sampling in prediction space for SINDyC, FNN, and GRU, allowing the learning process to prioritize dynamically informative trajectories. The proposed approach is demonstrated on the glycol heat exchanger (GHX) subsystem of the Thermal Energy Distribution System (TEDS) at Idaho National Laboratory. Across key GHX outputs--the bypass mass flow rate $\dot{m}_{\mathrm{GHX}}$ and heat transfer rate $Q_{\mathrm{GHX}}$-the AL framework achieves comparable predictive accuracy using as few as one-fifth of the simulation trajectories required by random sampling. Among the evaluated surrogates, the GRU achieves the highest predictive fidelity, while SINDyC remains the most computationally efficient and interpretable. The probabilistic MvG-SINDyC surrogate further enables uncertainty quantification and exhibits the largest computational gains under AL.

This study proposes a scalable Digital Twin framework for energy optimization in data centers.The framework integrates IoT-based data acquisition, cloud computing, and machine learning techniques to enable real-time monitoring, forecasting, and intelligent energy management. A controlled small-scale data center environment was developed to monitor variables such as power consumption, temperature, and computational workload. Long Short-Term Memory (LSTM) models were employed to predict energy demand and support operational decision-making. Experimental results demonstrated improvements in energy efficiency, including reductions in power consumption and enhancements in Power Usage Effectiveness (PUE). Despite being evaluated in a constrained environment, the proposed framework demonstrates strong potential as a scalable and cost-effective solution for sustainable data center management.

Monitoring high-dimensional engineering structures in extreme environments is limited by non-stationary excitation, nonlinear structural kinematics, and stochastic forcing. Traditional model-based and black-box data-driven methods often struggle to resolve these dynamics in real time, particularly under sensor failure or partial observability. This paper introduces a rank-optimized digital twin framework based on Koopman operator theory, Hankel-matrix embeddings, and dynamic mode decomposition. By lifting operational data into a linear invariant subspace, the method enables autonomous, input-blind reconstruction of structural states without requiring a priori mass or stiffness matrices. The framework is validated on an NREL 5MW spar-buoy floating offshore wind turbine, representing a challenging coupled aero-hydro-servo-elastic system. Results show that the rank-optimized Koopman-Hankel manifold separates structural resonances from deterministic 3P rotor harmonics under colored noise, where standard subspace identification can be unreliable. A rolling-horizon virtual sensing strategy achieves high-fidelity reconstruction at critical structural hotspots, with coefficient of determination greater than 0.95 at 1 Hz data assimilation and accuracy exceeding 0.99 at higher sampling rates. By estimating a physical Lyapunov time of approximately 1.0 s, the study defines the predictability horizon associated with the system information barrier. The proposed framework provides a computationally efficient and resilient digital twin approach for real-time identification and virtual sensing of complex structural dynamics.

Network digital twins (NDTs) are transforming network management by offering precise virtual replicas of physical network systems. However, their reliance on diverse and sensitive data introduces significant challenges related to data management, regulatory compliance, and user privacy. In scenarios where selective data removal is necessary, such as device deactivation, network reconfiguration, or regulatory compliance, traditional approaches often fall short of preserving the integrity of the twin model. To address this gap, we introduce a network digital untwinning framework that enables the targeted removal of deprecated NDT contributions while maintaining model integrity. Our approach comprises two complementary components: Single Request Untwinning (\algO) and Parallel Request Untwinning (\algM) mechanisms. \algO leverages connectivity metrics based on geographical proximity, data distribution, and network-level attributes to identify and remove the target NDT along with its propagating influence. This is achieved through an optimally selected rollback checkpoint augmented with injected Gaussian noise, followed by a precise remapping phase. \algM extends this mechanism to efficiently handle multiple removal requests by clustering NDTs with similar attributes and performing a coordinated rollback and untwinning schedule. We provide theoretical guarantees on model indistinguishability from scratch-built twins, and validate the framework through extensive experiments on real-world traffic data, demonstrating its effectiveness and operational efficiency.

This article outlines a new framework of traffic light optimization through a digital twin of the transport infrastructure, managed by agentic AI to ensure real-time autonomous decisions. The framework relies on physical sensors and edge computing to measure real-time traffic information and simulate traffic flow in a constantly updated digital twin. The traffic light is automatically controlled through the digital twin according to traffic congestion, travel delay and traffic patterns. This approach is implemented as a three-layer system: perception, conceptualization and action. The perception layer receives data on physical systems; the conceptualization layer uses LangChain to process the data; and the action layer links to the Model Context Protocol (MCP) and traffic management APIs to implement optimised traffic signal control algorithms. The results show that the framework minimizes waiting time at traffic lights and positively affects the effectiveness of the entire traffic flow, which is better than the fixed-time and reinforcement learning-based baselines.

Cognitive decline is highly heterogeneous across individuals, which complicates prognosis, trial design, and treatment planning. We present the Personalized Cognitive Decline Assessment Digital Twin (PCD-DT), a multimodal and uncertainty-aware framework for modeling patient-specific disease trajectories from sparse, noisy, and irregular longitudinal data. The framework combines three methodological components: (1) latent state-space models for individualized temporal dynamics, (2) multimodal fusion for clinical, biomarker, and imaging features, and (3) uncertainty-aware validation and adaptive updating for robust digital twin operation. We also outline how conditional generative models can support data augmentation and stress testing for underrepresented progression patterns. As a preliminary feasibility study, we analyze longitudinal TADPOLE trajectories and show clear separation between cognitively normal and Alzheimer's disease cohorts in ADAS13, ventricle volume, and hippocampal volume over five years. We further conduct a multimodal next-visit prediction ablation using an LSTM sequence model on 3{,}003 visit-pair sequences derived from TADPOLE, where the combined cognitive plus MRI configuration achieves the lowest standardized RMSE for both ADAS13 (0.4419) and ventricle volume (0.5842), outperforming a Last Observation Carried Forward baseline. A Bayesian tensor modeling component for high-dimensional imaging fusion is also discussed. These results support the feasibility of the proposed architecture while also highlighting the need for stronger uncertainty calibration and longer-horizon predictive evaluation. The PCD-DT framework provides a principled starting point for personalized in silico modeling in neurodegenerative disease. This work positions PCD-DT as a foundational step toward clinically deployable, uncertainty-aware digital twin systems.

Open, unclassified research on secure autonomy is constrained by limited access to operational platforms, contested communications infrastructure, and representative adversarial test conditions. This paper presents a threat-oriented digital twinning methodology for cybersecurity evaluation of learning-enabled autonomous platforms. The approach is instantiated as an open-source, modular twin of a representative autonomy stack with separated sensing, autonomy, and supervisory-control functions; confidence-gated multi-modal perception; explicit command and telemetry trust boundaries; and runtime hold-safe behavior. The contribution is methodological: a reproducible design pattern that translates threat analysis into observable, controllable tests for spoofing, replay, malformed-input injection, degraded sensing, and adversarial ML stress. Although the implemented proxy is ground based, the architecture is intentionally framed around stack elements shared with UAV and space systems, including constrained onboard compute, intermittent or high-latency links, probabilistic perception, and mission-critical recovery behavior. The result is an implementable research scaffold for dependable and secure autonomy studies across UAV and space domains.

Predicting individual cognitive decline in Alzheimer's disease (AD) is difficult due to the heterogeneity of disease progression. Reliable clinical tools require not only high accuracy but also fairness across demographics and robustness to missing data. We present CognitiveTwin, a digital twin framework that predicts patient-specific cognitive trajectories. The model integrates multi-modal longitudinal data (cognitive scores, magnetic resonance imaging, positron emission tomography, cerebrospinal fluid biomarkers, and genetics). We use a Transformer-based architecture to fuse these modalities and a Deep Markov Model to capture temporal dynamics. We trained and evaluated the framework using data from 1,666 patients in the TADPOLE (Alzheimer's Disease Neuroimaging Initiative) dataset. We assessed the model for prediction error, demographic fairness, and robustness to missing-not-at-random (MNAR) data patterns. ognitiveTwin provides accurate and personalized predictions of cognitive decline. Its demonstrated fairness across patient demographics and resilience to clinical dropout make it a reliable tool for clinical trial enrichment and personalized care planning.

Here, we explore the problem of error propagation mitigation in modular digital twins as a sequential decision process. Building on a companion study that used a Hidden Markov Model (HMM) to infer latent error regimes from surrogate-physics residuals, we develop a Markov Decision Process (MDP) in which the inferred regimes serve as states, corrective interventions serve as actions, and a scalar reward that takes into consideration the cost-benefit tradeoff between system fidelity and maintenance expense. The baseline transition matrix is extracted from the HMM-learned parameters. We then extend the formulation to a Partially Observable MDP (POMDP) that accounts for the imperfect nature of regime classification by maintaining a belief distribution updated via Bayesian filtering, with the HMM confusion matrix serving as the observation model. Both formulations are solved via dynamic programming and validated through Gillespie stochastic simulation. We then benchmark two model-free reinforcement learning algorithms, Q-learning and REINFORCE, to assess whether effective policies can be learned without explicit model knowledge. A systematic comparison of different intervention policies demonstrates that the MDP policy achieves the highest cumulative reward and fraction of time in nominal operation, while the POMDP recovers approximately 95% of MDP performance under realistic observation noise. Sensitivity analyses across observation quality, repair probability, and discount factor confirm the robustness of these conclusions, and the major gaps in the policy hierarchy are statistically significant at $p < 0.001$. The gap between MDP and POMDP performance quantifies the value of information providing a principled criterion for investing in improved classification accuracy.

Digital twins of natural systems must remain aligned with physical systems that evolve over time, are only partially observed, and are typically modeled by mechanistic simulators whose parameters cannot be measured directly. In such settings, model adaptation is naturally posed as a simulation-based inference problem. However, sparse and indirect observations often fail to identify a unique and optimal calibration, leaving several simulator parameterizations compatible with the available evidence. This article presents a GFlowNet-based approach to model adaptation for digital twins of natural systems. We formulate adaptation as a generative modeling problem over complete simulator configurations, so that plausible parameterizations can be sampled with probability proportional to a reward derived from agreement between simulated and observed behavior. Using a controlled environment agriculture case study based on a mechanistic tomato model, we show that the learned policy recovers dominant regions of the adaptation landscape, retrieves strong calibration hypotheses, and preserves multiple plausible configurations under uncertainty.

Wastewater treatment plants (WWTPs) need digital-twin-style decision support tools that can simulate plant response under prescribed control plans, tolerate irregular and missing sensing, and remain informative over 12-36 h planning horizons. Meeting these requirements with full-scale plant data remains an open engineering-AI challenge. We present CCSS-RS, a controlled continuous-time state-space model that separates historical state inference from future control and exogenous rollout. The model combines typed context encoding, gain-weighted forcing of prescribed and forecast drivers, semigroup-consistent rollouts, and Student-t plus hurdle outputs for heavy-tailed and zero-inflated WWTP sensor data. On the public Avedøre full-scale benchmark, with 906,815 timesteps, 43% missingness, and 1-20 min irregular sampling, CCSS-RS achieves RMSE 0.696 and CRPS 0.349 at H=1000 across 10,000 test windows. This reduces RMSE by 40-46% relative to Neural CDE baselines and by 31-35% relative to simplified internal variants. Four case studies using a frozen checkpoint on test data demonstrate operational value: oxygen-setpoint perturbations shift predicted ammonium by -2.3 to +1.4 over horizons 300-1000; a smoothed setpoint plan ranks first in multi-criterion screening; context-only sensor outages raise monitored-variable RMSE by at most 10%; and ammonium, nitrate, and oxygen remain more accurate than persistence throughout the rollout. These results establish CCSS-RS as a practical learned simulator for offline scenario screening in industrial wastewater treatment, complementary to mechanistic models.

Network change validation remains a critical yet predominantly manual, time-consuming, and error-prone process in modern network operations. While formal network verification has made substantial progress in proving correctness properties, it is typically applied in offline, pre-deployment settings and faces challenges in accommodating continuous changes and validating live production behavior. Current operational approaches typically involve scattered testing tools, resulting in partial coverage and errors that surface only after deployment. In this paper, we present Aether, a novel approach that integrates Generative Agentic AI with a multi-functional Network Digital Twin to automate and streamline network change validation workflows. It features an agentic architecture with five specialized Network Operations AI agents that collaboratively handle the change validation lifecycle from intent analysis to network verification and testing. Aether agents use a unified Network Digital Twin integrating modeling, simulation, and emulation to maintain a consistent, up-to-date network view for verification and testing. By orchestrating agent collaboration atop this digital twin, Aether enables automated, rapid network change validation while reducing manual effort, minimizing errors, and improving operational agility and cost-effectiveness. We evaluate Aether over synthetic network change scenarios covering main classes of network changes and on past incidents from a major ISP operational network, demonstrating promising results in error detection (100%), diagnostic coverage (92-96%), and speed (6-7 minutes) over traditional methods.

Learning robust robot policies in real-world environments requires diverse data augmentation, yet scaling real-world data collection is costly due to the need for acquiring physical assets and reconfiguring environments. Therefore, augmenting real-world scenes into simulation has become a practical augmentation for efficient learning and evaluation. We present a generative framework that establishes a generative real-to-sim mapping from real-world panoramas to high-fidelity simulation scenes, and further synthesize diverse cousin scenes via semantic and geometric editing. Combined with high-quality physics engines and realistic assets, the generated scenes support interactive manipulation tasks. Additionally, we incorporate multi-room stitching to construct consistent large-scale environments for long-horizon navigation across complex layouts. Experiments demonstrate a strong sim-to-real correlation validating our platform's fidelity, and show that extensively scaling up data generation leads to significantly better generalization to unseen scene and object variations, demonstrating the effectiveness of Digital Cousins for generalizable robot learning and evaluation.

While traditional AI and data-driven facilities management approaches have improved building operational efficiency, they remain constrained by centralized organizational structures that are vulnerable to cyber attacks, limited contextual understanding, and decision-making processes that exclude key stakeholders from governance. This paper introduces a novel AI- and data-driven distributed governance framework for smart building management that integrates decentralized autonomous organizations (DAOs), digital twins, large language models (LLMs), and blockchain technology. The framework enables transparent collective decision-making through a DAO governance platform, implements data-driven management using IoT and digital twins, incorporates LLM-based virtual assistants for enhanced decision support, and utilizes blockchain for secure building automation. A full-stack decentralized application was developed to facilitate user interaction with these integrated components. The system was evaluated for cost efficiency, scalability, data security, and usability using the System Usability Scale (SUS). Expert interviews were also conducted to assess its practical benefits and implementation challenges.

Network Digital Twins (NDTs) enable safe what-if analysis for 6G cloud-edge infrastructures, but adoption is often limited by fragmented workflows from telemetry to validation. We present a data-driven NDT framework that extends 6G-TWIN with a scalable pipeline for cloud-edge telemetry aggregation and semantic alignment into unified data models. Our contributions include: (i) scalable cloud-edge telemetry collection, (ii) regime-aware feature engineering capturing the network's scaling behavior, and (iii) a validation methodology based on Sign Agreement and Directional Sensitivity. Evaluated on a Kubernetes-managed cluster, the framework extrapolates performance to unseen high-load regimes. Results show both Deep Neural Network (DNN) and XGBoost achieve high regression accuracy (R2 > 0.99), while the XGBoost model delivers superior directional reliability (Sa > 0.90), making the NDT a trustworthy tool for proactive resource scaling in out-of-distribution scenarios.

Building high-fidelity digital twins of articulated objects from visual data remains a central challenge. Existing approaches depend on multi-view captures of the object in discrete, static states, which severely constrains their real-world scalability. In this paper, we introduce Articulat3D, a novel framework that constructs such digital twins from casually captured monocular videos by jointly enforcing explicit 3D geometric and motion constraints. We first propose Motion Prior-Driven Initialization, which leverages 3D point tracks to exploit the low-dimensional structure of articulated motion. By modeling scene dynamics with a compact set of motion bases, we facilitate soft decomposition of the scene into multiple rigidly moving groups. Building on this initialization, we introduce Geometric and Motion Constraints Refinement, which enforces physically plausible articulation through learnable kinematic primitives parameterized by a joint axis, a pivot point, and per-frame motion scalars, yielding reconstructions that are both geometrically accurate and temporally coherent. Extensive experiments demonstrate that Articulat3D achieves state-of-the-art performance on synthetic benchmarks and real-world casually captured monocular videos, significantly advancing the feasibility of digital twin creation under uncontrolled real-world conditions. Our project page is available at https://maxwell-zhao.github.io/Articulat3D/.

Large language models (LLMs) act as digital twins for human respondents, yet their psychometric comparability remains uncertain. We propose a construct validity framework spanning construct representation and the nomothetic span, benchmarking models against human gold standards. Across studies, digital twins achieved high aggregate-level accuracy and profile correlations, but showed attenuated item-level correlations. In word association tests, LLM networks exhibited humanlike small-world structure and theory-consistent communities, yet diverged lexically and in local structure. In decision-making and contextualized tasks, they under-reproduced heuristic biases, demonstrating normative rationality, compressed variance, and limited temporal sensitivity. Feature-rich and trait relevant conditioning improved Big Five personality prediction and nomothetic-span alignment, but network invariance remained limited, with partial configural solutions and persistent loading differences. In cross-language free-text tasks in English and Chinese, feature-rich digital twins better approximated construct-level narrative content, but linguistic and idiographic differences persisted. These findings clarify that digital twins are most useful within validated boundaries, where the construct, task and level of inference align with evidence from human data.