Digital Twins

The study of opinion dynamics in social networks is one of the key challenges in computational social science with direct relevance to understanding political polarization, misinformation, and health responses. Current approaches focus on simplified mathematical models that ignore linguistic and contextual factors related to belief updates or use Large Language Model (LLM)-based simulations that have not been validated against real data. We present a framework based on the concept of a digital twin to simulate opinion dynamics in social networks. The approach fills the gap by cloning a real-world Twitter network, assigns a set of attributes for agents (such as persona, emotions, centrality, stubbornness, and influence), and employs Mistral-7B to perform opinion update based on memory and social exposure. To evaluate the proposed approach, we validate it against two real Twitter datasets (COVID-19 discourse and U.S elections 2020). The results show that the capability of the proposed framework reproduces opinion trajectories and reduces individual prediction error by more than 50% compared to the best-performing classical baseline (Mistral-7B achieves Mean Absolute Error (MAE) = 0.150 and 0.121 on the COVID-19 and US Election 2020 datasets, respectively). We observe similar improvements in structural alignment (Delta_r = 0.120 and 0.180) and polarization dynamics (Delta_Var = 0.106 and 0.115) on the two datasets, respectively. Additionally, the ablation studies confirm that agent attributes, memory, and social exposure all contribute to the framework's predictive fidelity in reproducing opinion trajectories, with agent attributes being the most critical contributor. Overall, our results demonstrate that grounding Mistral-7B within empirically cloned interaction networks produces a realistic simulation framework capable of reproducing complex social dynamics.

Modern networks must support changing topologies, configurations, and performance objectives, motivating fast and reliable performance estimation. Network digital twins (NDTs) enable what-if analysis for performance estimation in such network scenarios, however, existing machine learning-based NDT approaches often rely on entire topology representations, which are inherently monolithic and lack reusability under topological or traffic changes in the network. This paper introduces a composable NDT approach that decomposes networks into subgraphs represented by reusable unit twins that capture subgraph structure, configuration and traffic behaviours. A lightweight composer aggregates unit twin combinations to create NDTs that predict per-route end-to-end latency through an overall topology. Evaluation across controlled synthetic topologies and diverse traffic scenarios, real-world Topology Zoo topologies, and a public NDT challenge dataset demonstrates that the composable NDTs achieve high in-distribution accuracy while remaining stable under out-of-distribution scenarios. Comparison with monolithic full topology NDTs demonstrates that our composable approach achieves reusability, while achieving comparable or superior accuracy.

The purpose of this paper is the identification of high-fidelity digital twin data models from numerical code outputs by non-intrusive techniques (i.e., not requiring Galerkin projection of the governing equations onto the reduced modes basis). In this paper the author defines the concept of the digital twin data model (DTM) as a model of reduced complexity that has the main feature of mirroring the original process behavior. The significant advantage of a DTM is to reproduce the dynamics with high accuracy and reduced costs in CPU time and hardware for settings difficult to explore because of the complexity of the dynamics over time. This paper introduces a new framework for creating efficient digital twin data models by combining two state-of-the-art tools: randomized dynamic mode decomposition and deep learning artificial intelligence. It is shown that the outputs are consistent with the original source data with the advantage of reduced complexity. The DTMs are investigated in the numerical simulation of three shock wave phenomena with increasing complexity. The author performs a thorough assessment of the performance of the new digital twin data models in terms of numerical accuracy and computational efficiency.

City pedestrian counting systems now feed economic indicators, planning decisions and safety operations, yet the twins built on top of them treat the incoming stream as ground truth. We study what happens when it is not. We formalise stealthy false data injection for city-scale pedestrian sensing, where the map from latent flow to observation is far more rank deficient than in the power and water networks for which stealth has been characterised. Our twin estimates directed flows on the pedestrian street graph, assimilates counts through a learned graph-localised gain, and is trained against a flow conservation residual that couples metered and unmetered segments. Detection combines the innovation with that residual, and the alarm threshold is set by adaptive conformal calibration rather than by hand. To measure what the physics buys, we define the attack margin, the relative reduction in worst-case corruption of the estimated flow field, achieved against a white-box adversary that optimises directly through the twin. On six years of Melbourne data the margin reaches 0.54 against a single compromised device and falls to 0.19 when a third of the fleet is compromised, on a network where only 1.18 per cent of walkable segments are metered. Replacing the street graph by a distance graph collapses it to 0.09, which shows that the gain comes from the conservation law rather than from locality.

In-context learning (ICL) enables models to infer tasks from demonstrations, but existing benchmarks generally lack matched text and image versions needed to compare ICL performance across modalities. We introduce TwinICL, a procedurally generated benchmark providing such pairs for controlled comparison. Across six open-weight models and 38 tasks, multimodal ICL consistently underperforms text-only ICL, with gaps varying by task family. To test whether this gap can be recovered, we target visual access, task framing, and reasoning through three interventions. Their combination recovers strong multimodal ICL performance on a diagnostic subset, despite limited or inconsistent individual effects. To distinguish difficulties in executing tasks from those in inferring them, we evaluate models with explicit task instructions, revealing a modality gap even when the task is known. We then examine how adding demonstration inputs and outputs reshapes this gap, highlighting demonstrations' dual role as additional context to process and evidence about the task. The dataset is available at https://github.com/lab-flair/TwinICL.

Autonomous network management requires systems that can evaluate Network Service Intents (NSIs) under varying conditions without manual implementation of analysis logic, as envisioned in TM Forum Level~4 (L4) autonomy. Behavioral Network Digital Twins (NDTs) enable such evaluation, but existing NDTs rely on pre-defined analytical logic, limiting adaptability for evolving closed-loop control. This paper introduces the NDT factory, a multi-agent software system that synthesizes executable behavioral NDTs on demand from semantic models using Large Language Model (LLM). We validate the system using a Call Admission Control (CAC) case study, where deterministic what-if analysis serves as the admission decision process. The NDT factory generates a complete CAC NDT through parallel synthesis and orchestration, achieving 100% compilation and test pass rates across multiple runs. Simulation over 300 NSIs shows 99.3% decision agreement with a reference implementation, 90% admission rate, and correct attribution of all rejections, demonstrating reliable synthesis with deterministic, verifiable execution.

Enterprise Digital Twins (EDTs) promise data-driven decision support at organizational scale, but realizing them requires navigating siloed departments, tacit knowledge, and high-stakes decisions with long-horizon consequences. Existing approaches involve domain experts during model development but focus less on early organizational buy-in in EDTs. We present a vision for trustworthy EDT engineering grounded in an `involving before evolving' paradigm: rapidly involving stakeholders through a working prototype before evolving toward federation and full interoperability. Our three-stage approach combines foundation models for rapid prototyping, an ontological backbone for federated interoperability, and observability tooling for stakeholder trust. We ground our vision in an ongoing collaboration with Michelin, a multinational manufacturer, where an initial prototype has helped support stakeholder buy-in.

We introduce GenOR-Twin, a neuro-symbolic framework that bridges the translation gap between unstructured operational logs and rigorous mathematical optimization. Our architecture uniquely positions Large Language Models as semantic translators rather than direct solvers, ensuring that the system retains the feasibility guarantees of exact combinatorial methods. { \color{red}We design a dynamic constraint injection mechanism (the runtime translation of qualitative disruption events into formal mathematical constraints) that allows the system to structurally modify the optimization problem's feasibility region in real-time based on qualitative human inputs. The resulting bidirectional coupling---where operational observations update the virtual model state and optimized decisions are reflected back into the Knowledge Graph---satisfies the synchronization requirement of a proper Digital Twin. The framework features an adaptive decision policy} that automatically selects between low-complexity schedule repair and full re-optimization by analyzing the available system slack. Finally, we demonstrate the generalization of this approach across six distinct optimization domains, {\color{red}turning static models into resilient systems that adapt to the operational uncertainty and variability of real-world environments.}

Post-treatment MRI in patients with glioma provides serial observations for updating patient-specific tumor-state proxy estimates, but variable appearances and trajectories complicate forecasting. We formulate forecasting as an observation-aware digital-twin update in which an intermediate observation anchors the patient-specific state. Among 203 patients and 594 follow-up time points, a predefined no-new-treatment criterion retained 120 of 236 candidate triplets, split into 81/24/15 training/validation/test triplets at the patient level. Each time point was represented by a continuous voxel-wise tumor-state proxy map in [0,1] derived from MRI lesion labels. A SegMamba-based single-step forecaster predicted update proposals from multimodal source-state tensors. Observation-Anchored Selective Assimilation (OASA) retained the observed intermediate proxy as the state anchor and selectively applied updates through a validation-selected tiered case-level rule and voxel-wise soft gate. We compared initial-scan forecasting, rollout without assimilation, latest-observation persistence, direct prediction, OASA, OASA + calibration, and morphological dilation. Checkpoints, OASA rules, and calibration thresholds were selected using validation data only. Across three seeds on 15 held-out test triplets, OASA maintained Dice at $\tau$ = 0.2 comparable to persistence (0.6071 $\pm$ 0.0025 vs. 0.6070) while yielding numerically higher Dice at $\tau$ = 0.5 (0.4269 $\pm$ 0.0079 vs. 0.3981), with a small RMSE increase. Calibration increased Dice at $\tau$ = 0.2 to 0.6178 $\pm$ 0.0025, increased false-positive (FP) support (11,836$\rightarrow$18,663), and reduced false-negative (FN) support (22,107$\rightarrow$17,536). This reflects near-threshold support calibration rather than improved biological predictive capability. Code is publicly available at https://github.com/jsudg436/longitudinal-proxy-forecasting.

As Digital Twin (DT) systems evolve beyond state synchronization toward task-oriented and knowledge-driven operation, Cognitive Digital Twins (CDTs) have emerged as an extension that incorporates cognitive capabilities into twin operation. Existing CDT studies often focus on specific enabling techniques, such as learning modules, knowledge graphs, and large language models, while providing limited insight into how cognition can be systematically integrated into DT architectures. To address this issue, this paper proposes a four-layer CDT architecture consisting of the physical layer, digital-twin layer, cognitive layer, and task layer. The proposed architecture establishes a self-evolving closed operational loop spanning these four layers, in which physical states are synchronized into digital representations, cognition constructs task-specific cognitive models through knowledge, memory, and attention, and task-level decisions are generated under practical constraints. Operational feedback further refines cognitive experience and updates relationships and annotations in the digital representation, enabling subsequent task interpretation, initiation, and reasoning to evolve with system operation. Based on this framework, two representative operation modes are characterized: user-request-driven cognition and self-driven cognition. We further discuss key enabling mechanisms and deployment challenges associated with semantic communication, knowledge querying, task orchestration, and closed-loop synchronization. A lightweight simulation study illustrates reliable closed-loop task feasibility under limited semantic information and improved operational efficiency through accumulated task experience. The proposed framework provides a structured foundation for the design and development of future CDT systems.

Rapid bespoke commissioning of the Cognitive Digital Twin (CDT) is a major challenge in reconfigurable manufacturing. Traditional digital twin (DT) construction methods primarily focus on geometric reconstruction, often neglecting the deep semantic integration and functional interoperability necessary for autonomous reasoning. This paper proposes an agent-based, AI-driven workflow to automate end-to-end CDT debugging. The system utilises LangGraph as a multi-agent orchestration engine to achieve dual-path synthesis: the semantic path extracts technical specifications from unstructured documents using Retrieval Augmented Generation (RAG), while the functional path autonomously discovers and binds to real-time industrial telemetry data using Model Context Protocol (MCP). Experimental validation in a robotic machining cell demonstrates that the system achieves a mean average accuracy (mAP) of 97.2% in perception and reduces the deployment cycle from several weeks to an average of 2 hours, marking a paradigm shift from manual scripting to autonomous orchestration.

LLM-based digital twins promise to reduce repeated human data collection by generating person- specific responses, yet existing evaluations provide little evidence about whether they can reduce human measurement while preserving valid inference. To address this, we introduce statistical substitutability, an inferential criterion that evaluates the extent to which twin predictions can reduce human measurement for a particular estimand while preserving valid inference. We develop a framework, grounded in mixed-subject and prediction-powered inference, that evaluates statistical substitutability along four dimensions: aggregate fidelity, paired respondent-level signal, finite-sample human-label recovery, and stability across populations. Across two empirical evaluations spanning behavioral experiments, multiple models, and alternative respondent representations, we find that digital twins can reproduce average human effects while providing little information about which individuals differ from those averages. Newer models and richer respondent information improve some dimensions of performance but do not reliably translate into human-data savings. Human calibration can reduce aggregate prediction error, yet limited labeled samples often fail to produce stable precision gains. Importantly, these findings demonstrate that behavioral fidelity is neither necessary nor sufficient for statistical substitutability. More broadly, they suggest that AI-generated evidence should be evaluated based on its ability to support valid scientific inference rather than its ability to reproduce human outcomes alone. Digital twins should therefore be judged for confirmatory use by whether they reduce uncertainty about human quantities, not merely by whether they reproduce human means, distributions, or effects.

3D reconstruction typically strives for geometric fidelity or visual plausibility. Radio frequency digital twins (RFDT) are instead judged by whether communication channels behave in them as they do in the real world. RFDTs promise site-specific channel prediction but current practice forces a choice between coarse automated scenes and hand-built, measurement-calibrated models that take weeks to construct per-site. We present KODAMA, an automated pipeline that reconstructs ray tracing-ready RFDTs at city scale from off-the-shelf geospatial data alone: aerial imagery, LiDAR, and photogrammetry yield terrain and watertight building meshes, while exposure-weighted multi-view fusion of street-level imagery recovers façade relief, electromagnetic materials, and clutter---all without site visits or calibration. Across three sites spanning 3.6 to 28 GHz, KODAMA's uncalibrated predictions achieve single-digit RMSE, reducing point-to-point error by up to 5.35 dB over automated baselines and coming within 0.22 dB of a measurement-calibrated, hand-built RFDT.

AI agents increasingly gather evidence, invoke tools, apply constraints, and produce decisions that people or software may commit to action. A final output alone cannot show which evidence, tool state, rule, authorization, or action path produced it. We present DNative-Twin, a graph-native digital twin that records a committed agentic decision as a typed trajectory and re-executes its decision mechanism under declared conditions. The graph links the state observed by the agent, the path it followed, and the authority behind the resulting action. The twin synchronizes this information, replays the mechanism in isolation, and compares it under controlled changes. We instantiate the framework in enterprise decision processes using three public process logs and controlled replay suites. The experiments identify a specific failure: graph structure localizes represented changes but cannot determine the consequence of an unobserved tool state. In a three-condition controlled experiment with 300 injected instances, unresolved-divergence recall increased from 0 to 0.667 when replay-contract state was added and to 1.0 when verification results were also available; the held-out set contained no critical-class instance. Across 500--5,000 BPI 2020 cases, median end-to-end time increased from 0.794 to 8.889 seconds on the reported platform. These results separate the roles of graph structure, replay context, and verification evidence in reviewing a decision mechanism.

The rapid growth of AI computing has driven increasing demands for flexible and high-capacity data-center interconnections. Owing to its ultra-wide bandwidth and high spatial reuse capability, terahertz (THz) communication has emerged as a promising solution for future wireless data centers, while digital twins (DTs) enable efficient wireless planning and real-time optimization. In this work, a measurement-driven multi-layer DT framework is proposed for THz wireless data centers, where the physical, channel, evaluation, and manipulation layers are progressively constructed from bottom to top. First, extensive channel measurements are conducted at 140, 220, and 300 GHz to characterize frequency-dependent propagation behaviors. Based on the tri-band measurements, a measurement-calibrated physical twin is established by jointly optimizing the geometry, material, antenna, and hybrid propagation models. On top of the physical twin, a line-of-sight (LoS)-aware implicit neural field is developed to construct an AI channel twin for efficient channel reconstruction. The proposed AI twin learns location-dependent channel statistics from the calibrated twin, enabling real-time prediction of received power and LoS probability. Building upon the reconstructed channel field, a system-level evaluation layer is derived to analyze coverage and interference for both AP-to-rack and rack-to-rack communications. Experimental results show that the proposed AI twin achieves lower power reconstruction error than existing neural-field baselines while maintaining real-time inference capability. Moreover, the ceiling-mounted AP deployment achieves over 90% coverage under a 10 dB signal-to-interference-plus-noise ratio (SINR) threshold, demonstrating the effectiveness of the proposed DT framework for THz wireless data-center planning and optimization.

Past literature on face recognition for monozygotic (("identical") twins points to facial marks and mirror asymmetry as possible directions for improved accuracy of twins recognition. The Celeb Twins Test Set (CTTS) contains web-scraped image pairs for 80 sets of celebrity twins. It is the only twins test set with meta-data for twins with distinguishing skin marks and possible mirror asymmetry. CTTS is organized in the manner of face verification test sets such as LFW, CALFW, CPLFW, CFP-FP, and AgeDB-30. Current deep CNN matchers can achieve over 76% accuracy in classifying CTTS same-person / different-person image pairs. We show that current matchers do not make use of skin marks, or asymmetry, and discuss reasons for this. Finally, we discuss the feasibility of using generative AI tools such as Grok, ChatGPT and Gemini to create images of imagined monozygotic twins as a means to increase representation of twins in face recognition training sets.

This paper introduces QXymb, a general framework for constructing observational declarative twins of quantum circuits, and develops QILP-0, its first complete order-0 specialization. QILP-0 constructs a finite multi-valued propositional logic program from observed circuit behaviour within a declared observational scope. The pipeline traverses a declared family of quantum observables incrementally according to a reproducible structural grading and a declared observational reference horizon. Progress is quantified through reference-relative coverage against a fixed target-independent reference. Observable responses are organized through target-independent geometry, while retained latent structure is mapped deterministically back to original observable columns before symbolic processing, preserving observational semantics and provenance. Selected observable profiles are converted into a finite relation through admissible target-independent discretization. The target is used only afterwards to audit twin-admissibility and induce the declarative theory. A theory is certified as an exact observational declarative twin when it completely and correctly reconstructs the resulting finite task-conditioned discrete relation. Logical exactness is therefore separated from numerical, backend, provider, and discretization uncertainty, which is retained as audit metadata. Validation uses two complementary QML settings. Exhaustive Bars & Stripes experiments compare product and grid-CZ embeddings from 16 to 100 qubits and exercise the native-discrete branch. Low-Depth MNIST analyses all 14,708 digit-0/1 instances before and after a trained variational quantum transformation and exercises continuous discretization. In every reported relation, the induced QILP-0 theory achieves complete, conflict-free reconstruction with strict accuracy equal to one.

Building a blockchain digital twin largely requires translating domain knowledge and specific system descriptions into a simulator architecture, calibrating its parameters against behavioral evidence, and validating the constructed twin. These steps are commonly performed through application-specific modeling efforts that can be difficult to reuse across systems and downstream decision problems. We consider automating this process through Spec2Twin-Chain, a framework that formulates blockchain digital-twin construction as a bi-level optimization problem. At the upper level, a large language model proposes and revises structurally admissible architectures using system specifications, behavioral evidence, and feedback from evaluated designs. At the lower level, a simulation-based optimizer calibrates the architecture-conditioned parameters under explicit objectives and guardrail constraints. The two levels iterate. The evaluated candidates at lower levels are retained in a global archive and used to guide subsequent proposals at upper levels. We conduct controlled experiments involving twin calibration, feedback-driven recovery, stress analysis, downstream policy optimization, and policy updating. The results demonstrate that the framework can construct behaviorally accurate twins, improve initial designs through iterative feedback, and reuse calibrated twins to support downstream decisions.

Digital twins are increasingly used to monitor and simulate the behavior of cyber-physical systems. Even with skilled operators, interpreting anomalies detected within digital twin pipelines is challenging, as the sheer complexity and volume of raw sensor data make thorough analysis difficult. Recent advances in large language models (LLMs) offer promising capabilities for reasoning and explanation, yet their integration into digital twin-driven anomaly analysis remains underexplored. In this work, we propose AgenticTwin, an agentic framework that integrates LLM-driven reasoning with a digital twin-based anomaly detection pipeline. The framework grounds LLM-generated explanations in outputs from a digital twin-driven anomaly classifier and enables human operators to ask relevant natural-language questions about the system. Beyond the framework itself, we introduce a benchmark-oriented evaluation pipeline constructed over synthetic anomalies injected into a real-world weather sensor dataset, enabling controlled generation of operator queries over anomaly events. We further evaluate the feasibility of deploying lightweight, open-source LLMs for practical cyber-physical environments. Experimental results demonstrate that structured agent collaboration and knowledge-grounded reasoning improve diagnosis quality, contextual retrieval, and mitigation quality across diverse possible anomaly scenarios.

Accurate physical-layer modeling is increasingly essential for reliable ultra-wideband operation and capacity optimization, especially under the intensified inter-channel stimulated Raman scattering (ISRS) effect. This paper proposes the link-adaptive digital twin (LA-DT) for hybrid-amplified ultra-wideband links to overcome the generalization and speed limitations of existing methods, achieving accurate modeling and robust generalized signal-to-noise ratio (GSNR) estimation across diverse links. First, to address EDFA heterogeneity, the GSNR modeling task is decomposed into three key power predictions: ASE, NLI, and signal powers before EDFA entry. Second, to enhance cross-scenario generalization, three dedicated DT models are developed using a novel neural architecture with linear modulation layers (LMLs). Third, for rapid adaptation to unseen scenarios with limited data, three domain discriminators guide few-shot fine-tuning of the LMLs. Fourth, the LA-DT explicitly accounts for Raman amplifier (RA) insertion loss, improving practical deployment reliability. Results across 35 scenarios show that LA-DT reduces RMSE for NLI, ASE, and signal power predictions to 0.151, 0.111, and 0.113 dBm with improvements of 56.0%, 58.4%, and 52.7% over the baseline,and achieves an average GSNR estimation RMSE of 0.114 dBm (55.8% improvement). For 12 unseen scenarios, the LA-DT maintains high accuracy through few-shot fine-tuning with only 20 samples per scenario, achieving an average GSNR RMSE of 0.159 dB and demonstrating strong adaptability and robustness.

Digital-twin calibration requires interaction data that is expensive to collect. We study two acquisition decisions: which trajectories to generate, and when to spend a limited budget on privileged parameter measurements. Our framework couples an excitation-oriented reinforcement learning controller, a recurrent parameter estimator with predictive uncertainty, and a budgeted query policy. In Pendulum, a Random Forest diagnostic recovers gravity only weakly from task-oriented trajectories and does not recover mass or length, while a GRU trained on excitation-oriented trajectories reaches a mean absolute error of 0.0066 with no queries. We then withdraw continuous oracle access partway through an episode, so that the twin must run on the estimator's output for the remainder. The estimator-plus-policy pipeline achieves a terminal error of 0.0092 under a three-query budget, against 0.2031 for an uncalibrated twin. In partially observable Waterworld, five controllers produce different observed error profiles across three hidden parameters, and an estimator trained on a five-controller mixture reaches online normalized errors of roughly 4-5%. These exploratory case studies are not controlled ablations, but they motivate treating trajectory design and query allocation as explicit design variables in data-scarce calibration.

Despite advances in artificial intelligence (AI) across multiple sectors, today's AI tools, including deep learning and generative AI, still fail when embedded into physical systems, such as robots and vehicles operating under real-world physical laws. This stems from their inability to maintain reliable world models for long-horizon planning under uncertainty and generalize to unseen scenarios. In this context, wireless networks, through pervasive sensing and communication, can orchestrate physical intelligence. However, current architectures optimize throughput, latency, and reliability and cannot support real-time physical AI coordination, requiring agents to maintain shared spatiotemporal context. To address these challenges, a network of holonic digital twins (HDT-Nets) framework is proposed to deliver real-time physical AI inference through holonic agents that actively reason about their environment rather than passively mirror physical assets. Each HDT is realized as a hierarchical structure spanning the physical agent and network edge, reasoning autonomously at the local level while cooperating with neighboring HDTs to form collectively intelligent units. In HDT-Net, causal Markov blankets spanning sensing, communication, and control determine which agents must coordinate and enable counterfactual reasoning over multi-domain interventions. Active inference within these boundaries unifies perception, action, and learning by minimizing expected free energy while deciding which beliefs to transmit based on their cognitive value to the receiver. Category theory ensures that transmitted beliefs preserve semantic structure across heterogeneous agents with incompatible representations. Finally, integrated information theory quantifies when collective intelligence exceeds independent operation and how network intelligence evolves through coordinated learning and information exchange.

Reconstructing objects with mechanical properties from video observations enables physically consistent dynamic prediction, benefiting robotics planning and interaction. Existing spring--mass based physical driven reconstruction approaches offer efficient and differentiable physical reconstruction, but they typically rely on axial springs alone. Such formulations oversimplify the underlying structural mechanics and can become mechanically under-constrained when the physical graph is coarsened, limiting their ability to preserve stable local deformation. We present BendTwin, a bending-aware differentiable spring--mass framework for video-based reconstruction and future prediction of deformable objects. BendTwin introduces bending stiffness and damping over local surface triplets, penalizing deviations from rest angles and regularizing higher-order deformation. These bending constraints improve mechanical stability while preserving the simplicity of spring--mass system. Experiments show that BendTwin consistently outperforms the axial-only PhysTwin baseline. Ablation studies further demonstrate that the bending constraints maintain system stability across different downsampling ratios and consistently improve upon the original PhysTwin formulation. Overall, BendTwin provides an effective approach for constructing mechanically faithful digital twins from sparse-view RGB-D videos.

Online HD map construction is critical to prediction and planning in autonomous driving. We find that existing physical attacks against online map construction are limited by a cross-boundary compensation effect: after the target boundary is perturbed, another visible boundary may retain sufficient geometric cues for the model to recover the original road geometry. Based on this observation, we propose TwinIR, a new mechanism-guided physical attack methodology for online map construction. TwinIR jointly optimizes attack effectiveness and point sparsity, seeking the minimum number of attack points needed to suppress compensating geometric cues from surrounding boundaries. To reduce the perceptibility of multi-point attacks, TwinIR models camera responses to near-infrared illumination and maps optimized attack points to feasible physical placements, producing camera-visible interference with minimal visible-spectrum changes. Experiments on nuScenes across state-of-the-art online map construction models show that TwinIR reduces mAP by 8.18-8.96 percentage points under RSA and 2.84-5.62 points under ETA, while increasing the unreachable-goal rate by 25-28 points and the unsafe-planned-trajectory rate by 19-20 points over clean inputs. These attacks are also validated on a real-world testbed AV, where TwinIR successfully induces both road straightening and early-turn deformations while remaining inconspicuous in full-color views.

Quantitative longwave thermography of heritage surfaces is limited by the global-constant emissivity assumption in inverse-Planck temperature retrieval; on heterogeneous surfaces emissivity varies within one field of view, producing apparent-temperature artifacts that mimic and mask subsurface anomalies. We present a training-free pipeline that derives per-pixel emissivity by applying SAM 3.1 open-vocabulary segmentation to a colocated, co-calibrated RGB channel, mapping segments to a material-keyed LWIR emissivity table compiled from primary measurement literature, and propagating the field into a per-pixel inverse-Planck solve on raw radiometric data. Lacking any public dataset with raw radiometry, a temperature reference, and a colocated RGB camera, we evaluate on a physics-based synthetic benchmark and four real datasets. On the benchmark, under a palette spanning the low-emissivity exceptions, the correction cuts mean absolute error from 1.97 K to 0.91 K at 20 K contrast and, with an accurate table, beats the best fitted global constant on every layout; on a heritage-realistic emissivity distribution it does not. We contribute a quantified operating-regime map, and a measurement-backed finding that tempers the heritage claim: weathered outdoor heritage emissivities cluster near the conventional default, so the correction is small on typical surfaces and concentrated on genuine low-emissivity exceptions. We characterize the dominant failure mode, in which open-vocabulary segmentation matches appearance rather than material, and the contraindicated regime in which emissivity-defined anomalies are suppressed.

Social media affect financial markets, but public posts by financial media personas are voluntary disclosures. What is not disclosed is therefore usually unobserved. We address this measurement problem by conducting repeated, real-time interviews of "digital twins" built from monitored finfluencers' X accounts under a fixed protocol. The interviews recover stock-level public-persona belief proxies even when no public recommendation is made. Because the interviews are generated and archived before the relevant return windows, the design avoids the look-ahead bias that arises when LLMs are queried ex post. The evidence shows that information obtained from these digital-twin interviews predicts the cross section of large-cap stock returns in the expected direction. Repeated real-time interviews therefore show how selective disclosure can be turned into measurable panels of market views.

Head-and-neck (HN) proton therapy is highly sensitive to anatomical change over a 4-to-6-week course, as tumor shrinkage, weight loss, and setup variation can misposition the Bragg peak near critical organs such as the parotids, oral cavity, brainstem, and spinal cord, leading to target underdosing or organ-at-risk overdosing. Online adaptive proton therapy replans on the anatomy of the day, yet standard workflows rely on offline replanning that requires repeated CT acquisition and roughly a week of preparation, adding burden, cost, and delay. We investigate whether a patient's treatment-day anatomy can be predicted before image acquisition by transferring longitudinal change from a population database. We propose a digital-twin framework built on a pretrained foundation-model deformable registration network used without patient-specific training. A first registration aligns a prior patient's planning CT to the target and carries the prior's during-treatment quality assurance CT (QACT) into the target frame; a second registration estimates the prior's planning-to-QACT change, which is then applied to the target's own planning CT to synthesize predicted CTs (pdCTs) with propagated contours. Using 88 HN patients, each with a planning CT and three QACTs, we show that pdCTs better match treatment-day anatomy than the static planning CT. Compared with the planning CT alone, normalized cross-correlation improves by 22.8%, Dice for organs-at-risk by 20.2%, and CT-number error decreases by 23.4%. Gains are largest for patients with major anatomical change and negligible when anatomy is stable. This cross-patient motion transfer leverages the digital-twin concept to anticipate treatment-day anatomy, enabling personalized online adaptive proton therapy without repeated imaging.

Accurate indoor localization is essential for emerging applications in robotic navigation and search and rescue. While classical methods typically focus on single-point estimates, complex indoor environments with heavy blockage and multipath propagation often lead to multimodal likelihood surfaces where a single estimate is insufficient. This paper proposes LOCUS-DT (Localization via Observation-Conditioned Uncertainty Scoring with Digital Twins), a framework that treats snapshot localization as posterior inference over the transmitter location. By leveraging a ray-tracing-based digital twin (DT) of the known environment, LOCUS-DT generates synthetic multipath profiles for candidate locations and compares them against the measured channel profile. Central to our approach is a novel learned scoring function designed to compare a fixed number of dominant specular paths, providing robustness against errors in both the DT environment model and the physical channel estimation. Importantly, LOCUS-DT is trained over an ensemble of environments to ensure generalization to unseen layouts. We evaluate the system using a Sionna-based ray-tracing backend, demonstrating that LOCUS-DT captures the sharp, multimodal posterior structures inherent in indoor settings more accurately than standard Gaussian or Gaussian-mixture benchmarks.

Unified multimodal models seek a shared visual token space that supports both multimodal understanding and image generation. Discrete methods unify the interface via a shared codebook, whereas continuous pipelines often rely on two disparate representations -- semantic features (e.g., ViT) for understanding and low-level latents (e.g., VAE) for synthesis -- resulting in mismatched latent spaces. We propose Twins, a unified continuous token space formed by channel-wise concatenating ViT and VAE features on the same token grid, so the sequence length is unchanged and attention cost does not increase. However, jointly modeling Twins in a Diffusion Transformer exposes a severe optimization imbalance: the model fits the ViT component well but struggles to match the VAE latent distribution. We trace this imbalance to three sources of heterogeneity: frequency bias, intrinsic dimensionality, and condition-aligned vs condition-independent uncertainty. To address it, we adapt a focal regression objective for flow matching that upweights large-error VAE dimensions, better balancing optimization across the ViT and VAE components. On ImageNet, this yields up to 10.57 gFID gain over naive MSE loss without classifier-free guidance. Twins also performs competitively on multimodal understanding benchmarks and improves reconstruction fidelity, narrowing the gap between understanding- and generation-oriented representations.

Digital twins have emerged as a foundational technology within the context of Industry 4.0, offering a paradigm for the real-time virtual representation of physical systems. However, managing their growing complexity, particularly in distributed industrial environments, requires intelligent architectures capable of autonomous decision-making, dynamic adaptability, and inter-agent coordination. This systematic review explores the intersection between Multi-Agent Systems and Digital Twins, with a particular focus on predictive maintenance applications in resource-constrained contexts. Through a critical analysis of over 547 papers published in high-impact journals (IEEE Transactions, Nature, Elsevier, MDPI), we establish a taxonomy of existing hybrid architectures, identify persistent technological bottlenecks, and formulate three open research questions concerning: (i) the deployment of artificial intelligence on resource-constrained microcontrollers, (ii) distributed multi-node coordination via lightweight communication protocols, and (iii) the hierarchical orchestration of Digital Twins toward smart factory control integrating residual life estimation and explainable Artificial Intelligence. The results of this analysis reveal that, despite significant progress, no existing system offers an integrated embedded-distributed hierarchical solution that simultaneously meets the requirements of Industry 5.0.

Mobile-health interventions increasingly use online learning and decision making algorithms to personalize when to nudge users toward healthier behavior, but a poorly designed algorithm can burden and disengage participants. New algorithm design decisions should therefore be vetted against realistic simulated users before each real-life deployment. We propose a method to develop ``JITAI-Twins'': digital twins of a target subpopulation for comparing candidate online algorithms before a just-in-time adaptive intervention (JITAI) deployment. The method builds on a conditional time-series diffusion model that is temporally consistent (future actions do not affect the generated past), and it supports repeated updating from three sources of information, in three steps: pre-training on a large observational dataset, fine-tuning on small prior intervention deployments in related populations, and inference-time calibration to the next target population from domain-scientist expertise. We validate the twin at each pre-deployment stage of the long-running HeartSteps series (v2 through v4) of physical-activity suggestion intervention deployments, treating each successive deployment as an upcoming study. The proposed method reproduces the target subpopulation's temporal and between-participant structure better than simpler simulators. These results suggest that our twin can be used to simulate a target deployment before it runs, the prerequisite for testing and informing online algorithm design decisions.

Digital twins are often used to predict how a system would respond to an intervention. In systems with feedback, a twin must reproduce an equilibrium counterfactual, and a twin developed in one domain may fail after mechanisms change. We study when these predictions can be validated and transported. For equilibrium causal games, we give conditions on the mechanisms, equilibrium selection, and intervention design under which agreement with experimental distributions identifies the counterfactual of interest. We show why agreement of means and covariances is insufficient for distributional queries. We then introduce cyclic selection diagrams and derive criteria for direct reuse and for hybrid models that combine invariant source mechanisms with target information. An impossibility result constructs systems that agree under every experiment in a finite design but disagree on the target counterfactual, showing that validation requires structural assumptions. For linear models, we derive intervention requirements that depend on the mechanisms that changed, the observation model, and graph support. When point identification fails, we characterize the remaining range of query values. We also provide statistical tests for reconstructed means and covariances and illustrate the theory in synthetic feedback systems.

Smartphone personal assistants reason over longitudinal personal data, yet evaluating them requires context-rich evaluation data whose correct answers are known, and real device traces are too privacy-sensitive to share. To address this challenge, we present SenWorld, a physically grounded, deterministic, event-sourced digital-twin simulation that generates such data with ground truth fixed by construction. In SenWorld, personas live through a full day in a world built from real map, weather, holiday, and network data; every observable signal is archived in full-system snapshots; and each evaluation case is labeled by a pointer to an existing record rather than by post-hoc annotation or a large language model (LLM) judge. We evaluate this method with 16 personas in Beijing. The generated data closely matches the held-out real-user benchmark in category distribution (Jensen--Shannon divergence (JSD) 0.070) and in the daily rhythm of communication records (JSD below 0.1), though generated records remain shorter than real ones. Without scripted interaction, personas form a fully reciprocated dialogue subgraph and differentiated behavioral repertoires. Projected into 717 evaluation cases, the generated data exposes 78 failures in a production smartphone assistant, concentrating on call and Short Message Service (SMS) records while contacts, schedules, and alarms never fail. The snapshot pointer confirms each failure as an assistant-side retrieval error, with no LLM judge involved. Overall, SenWorld offers a privacy-safe, reproducible, and distribution-checked path to evaluation data whose labels are fixed by construction.

In efforts to increase research efficiency and availability, a digital twin of our research tractor (AMX G-trac) is created, focusing especially on the CAN communication for data reading and actuation command following the ISOBUS protocol. Mevea Simulation Software is utilized as the foundation, providing the kinematic model and visuals, while Python is used to read and write CAN messages over a Kvaser CanKing virtual CAN channel. Various performance tests involving straight line and turning behavior are performed in both the digital twin simulation and in the real world to measure similarity. Results indicate that the Mevea model behaves very comparable in its lateral dynamics, often within 5-10 percent, but requires better data to fully capture the longitudinal aspects like acceleration. The final model described in this paper sets the table for a second iteration to include more tractor functions such as hydraulics and tractor-implement dynamics.

Real-to-sim conversion for robotic interaction with objects remains labor-intensive because it requires more than visual reconstruction: a streamlined real2sim process must recover scene geometries and object states, infer physical parameters, and assemble actors, objects, cameras, poses, and trajectories into a runnable physical simulation. Today this process still depends on brittle workflow glue across visual perception tools and simulators: manual tuning of visual foundation models, mesh cleanup, coordinate frame alignments, etc. We introduce \textit{Agentic Real2Sim}, a framework for generalized physical world modeling with vision-language agents that converts a real-world recording of object-robot interaction into a simulatable episodic twin, and connects the resulting twin to downstream policy fine-tuning and evaluation. We evaluate Agentic Real2Sim on rigid-object manipulation, deformable-object interaction, and humanoid motion scenes, spanning domains that are usually handled by separate Real2Sim pipelines. The framework's agentic decisions can be driven by an open-weight VLM backend at a small fraction of the cost of frontier models, while attaining a comparable conversion success rate. The framework further supports custom scene conversion, fine-tuning of a pretrained policy with data generated from converted episodes, and works effectively as a surrogate for real-world policy evaluation. The project site, including code is available at https://agentic-real2sim.github.io.

Digital Twins rely on surrogate models to mirror physical systems in real time, yet these models can degrade as operating conditions evolve, a phenomenon known as concept drift. Maintaining surrogate fidelity under drift, particularly when models must also capture aleatoric uncertainty, remains an open challenge. Existing adaptive frameworks lack principled mechanisms for detecting when updates are needed, for efficiently adapting models from limited streaming data, and for certifying that updates genuinely improve predictive performance. Here we present an adaptive Digital Twin framework that integrates a Fisher score--based multivariate drift detector, Low-Rank Adaptation (LoRA) for parameter-efficient continual learning, and a Mann--Whitney $U$ test for online statistical validation. The framework monitors surrogate-model confidence via Fisher score vectors, triggers targeted fine-tuning of fewer than 1% of model parameters upon drift detection, and statistically certifies predictive improvement before deploying the updated surrogate. Applied to a stochastic linear system and a directed energy deposition additive manufacturing process as case studies, the framework successfully detects distributional shifts with short delays and restores both predictive accuracy and uncertainty quantification under abrupt and incremental drift. These results establish a statistically rigorous and computationally tractable pathway for sustaining the trustworthiness of neural-network--based Digital Twins throughout their operational life cycle.

This work addresses the need for engineering-grounded evaluation of implement-ed tariff mechanisms in distribution-level energy systems. A digital twin-based method is proposed for assessing local collective tariffs under realistic behavioral and infrastructural conditions. The approach integrates agent-based modeling of household consumption and generation, virtual aggregation through a shared metering abstraction, and explicit representation of tariff logic within a unified simulation environment. The method is demonstrated through its application to the Danish Local Collective Tariff across representative residential energy community configurations, including scenarios with photovoltaic generation, battery storage, and electric vehicle charging. Results indicate that aggregation of heterogeneous demand profiles reduces peak coincidence and enables more efficient allocation of tariff components, leading to measurable cost reductions at the community level. At the same time, the outcomes reveal sensitivity to the temporal alignment of consumption and generation, influencing the degree of cost neutrality across participants. The findings illustrate how digital twin-based evaluation can support systematic assessment of tariff mechanisms by capturing the interaction between infrastructure, user behavior, and regulatory design. The proposed approach provides a basis for analyzing and comparing tariff structures in distribution-level energy systems beyond the specific case considered.

Digital twins enable robots to anticipate and adapt to physical interactions, but existing models struggle with elastoplastic articulated objects (EAOs) that exhibit nonlinear elasticity, plastic yielding, and damage accumulation. We present BoxTwin, an interactive digital twin framework that learns the full dynamics of EAOs from videos. Our pipeline reconstructs the scene, identifies a physics aware constitutive model for each EAO. Experiments on manual folding and dual arm manipulation of EAOs show that BoxTwin accurately tracks joint trajectories and reproduces post contact plastic behavior over long horizons. By integrating video driven reconstruction with elastoplastic damage modeling, BoxTwin advances digital twins toward predictive, adaptive control of deformable articulated objects in unstructured environments.

The rapid digitalisation of elite sport has created new opportunities for integrating artificial intelligence (AI), performance analytics, and decision-support systems into athlete development and competition management. However, existing solutions remain fragmented, typically addressing isolated tasks such as performance analysis, athlete monitoring, or referee support. This paper presents \textbf{FST$\cdot$ai2.5}, an explainable, uncertainty-aware, and secure AI framework for Olympic and Para-Taekwondo. \textbf{FST$\cdot$ai2.5} introduces a unified digital ecosystem integrating athlete intelligence, competition analytics, federation-scale data management, AI-assisted decision support, athlete and event digital twins, explainable performance indicators, and adaptive training recommendations. The framework supports World Taekwondo (WT), Member National Associations (MNAs), coaches, referees, analysts, and athletes through transparent, secure, and federation-aware governance. By combining multi-source competition data, athlete-performance information, and contextual evidence, \textbf{FST$\cdot$ai~2.5} provides tactical diagnostics, longitudinal athlete monitoring, performance forecasting, personalised development planning, and federation-wide benchmarking using explainable and uncertainty-aware AI. Prototype deployments demonstrate the feasibility of the proposed framework. Although developed for Olympic and Para-Taekwondo, the methodology is broadly applicable to explainable AI, digital twins, and trustworthy decision support in combat sports and other high-performance sporting environments.

High-fidelity simulation of mmWave radar signals for dynamic human motion is valuable for developing radar-based human sensing models; yet collecting accurately labeled measurements for a specific deployment site remains expensive. We present HybridSim, a physics-learning hybrid simulator that synthesizes mmWave radar signals from dynamic human meshes under a fixed indoor room configuration, explicitly decoupling propagation into two components. To parameterize the human subject, we use a tri-plane representation to extract human features and a Graph Convolutional Network to stabilize optimization and mitigate gradient instability. The direct signal path is modeled via an inverse-rendering formulation with a microfacet BRDF to capture primary surface reflections. In parallel, the indirect path is approximated by combining 3D Gaussian Splatting with a virtual-receiver geometry to fit and reproduce site-specific multipath interference patterns, achieving substantially lower computational cost than explicit full ray tracing. Experiments in a fixed-room setting show improved agreement with a physically based reference and consistent gains on downstream radar-based human sensing tasks when using HybridSim for site-specific data augmentation.

Brain tumor progression exhibits spatially heterogeneous growth, patient-specific treatment response, and complex interactions with surrounding anatomy, making accurate long-term prediction challenging. We propose an AI-augmented adaptive digital twin (DT) framework for brain tumor evolution prediction and treatment scheduling. The framework integrates an interpretable reaction--diffusion (RD) model, a 3D residual learning module for model-form correction, patient-specific DT updating during recursive rollout, and model predictive control (MPC) for constrained chemotherapy and radiotherapy scheduling. Experiments on 387 synthetic tumor trajectories with 120-step evolution show that the baseline RD model captures tumor location and overall temporal behavior but underestimates heterogeneous tumor burden during long-horizon prediction. Hybrid RD--residual modeling reduces masked voxel-wise mean squared error by 84.3% and increases Dice overlap by 43.5% relative to the RD baseline under dense simulated observations. Online DT updating further reduces mean squared error by 45.9% and improves Dice overlap by 9.6% compared with the non-updated hybrid model. In MPC-based scheduling simulations, the updated DT controller reduces final tumor burden by 22.4% relative to a fixed treatment schedule under the terminal-burden objective. Together, these results demonstrate a unified framework for patient-specific initialization, mechanistic modeling, adaptive learning, and constrained treatment optimization. Although validated using patient-data-informed synthetic trajectories rather than clinical longitudinal data, the proposed framework establishes a foundation for future translation to real-world adaptive treatment planning.

This book chapter covers the evolution of social simulation from classical agent-based models, in which agents interact according to explicitly defined behavioral rules, to AI-enhanced simulations based on Large Language Models and, ultimately, Social Digital Twins: high-fidelity, data-driven representations of real-world socio-technical systems. Along this trajectory, we discuss the main methodological foundations, applications, advantages, and limitations of each paradigm, highlighting the progressive shift from abstract models designed to investigate general social mechanisms toward increasingly realistic computational representations of specific social systems.

Existing approaches to infer user traits and generate responses consistent with a persona rely on static prompting. They lack calibrated uncertainty, ignore sequential evidence, and drift during long interactions. We present \textbf{AI YOU}, a framework that continually updates a personality profile with 22 dimensions from conversation and embodies it in a personal digital twin. Practically, the system combines prompting, Bayesian updating, and conformal prediction for persona inference. A periodically refreshed memory anchor and cognitive memory with three layers preserve persona consistency over long interactions. Across the main results, AI YOU \emph{(i)} achieves conformal coverage ranging from 0.921 to 0.976, \emph{(ii)} improves uncertainty calibration and reasoning grounded in memory, and \emph{(iii)} enhances persona fidelity over static prompting in role playing over 100 turns while reducing trait drift, for most evaluated backbones under adversarial settings with multiple agents. The prototype \emph{AI YOU Town} initializes an imaginative twin world for future interaction. The online demo is available at \href{https://quinnnnnne-ai-you.hf.space/}{\mbox{\texttt{quinnnnnne-ai-you.hf.space}}}.

Embodied agent teams powered by heterogeneous large language models (LLMs) are being widely deployed in physical artificial intelligence such as smart factories, warehouses, and service robotics. To enable collaboration among such an agent team, efficient coordination mechanisms that operate reliably under limited network resources are required. However, existing heterogeneous LLM-agent coordination frameworks that rely on multi-round natural-language-based conversations introduce three coupled challenges. First, inter-agent dialogue incurs communication overhead that grows rapidly with team size. Second, the quality of coordination is constrained by the heterogeneous capabilities of the agent team's LLMs. Third, agents may suffer from action delays due to iterative negotiation. To address these challenges, we propose LDT-Coord, a networked coordination framework built upon a lightweight digital twin (DT). Specifically, each agent independently selects its intended action and reports both the action decision and a structured temporal constraint over shared resources to the DT server, thereby decoupling coordination performance from natural-language reasoning ability. Then, DT executes a training-free, rule-based orchestrator algorithm to resolve cross-agent conflicts and returns coordination instructions to prevent such conflicts. To further reduce communication overhead, we formulate agent reporting control as a constrained partially observable Markov decision process (C-POMDP) and solve it with the PPO-Lagrangian algorithm. Simulation results show that LDT-Coord achieves a task success rate comparable to conventional coordination methods while reducing communication overhead by more than 70x and maintaining robustness under LLM heterogeneity.

Federated reinforcement learning (FRL) is crucial for enabling collaborative learning across multiple agents without sharing raw data, thereby enhancing privacy and scalability in the decision-making process within dynamic vehicular environments. However, poisoning attacks pose a significant threat to the security and reliability of FRL-based systems, particularly in safety-critical autonomous driving, where this vulnerability remains largely unexplored. These attacks can compromise the global control model by subtly injecting malicious system parameters, leading to potential hazards. To counter these challenges, we present \alg (\underline{Sec}ure \underline{A}ggregation with \underline{p}oisoning-\underline{p}revention and historical reinforcement) as a defensive framework aimed at enhancing the robustness of FRL systems designed for safety-critical driving scenarios. \alg strategically integrates digital twins for rehearsal-based learning and leverages historical aggregated model parameters along with a selected central gradient to ensure that only benign data is aggregated, effectively mitigating the influence of malicious agents. Theoretical guarantees are provided for the convergence performance of \alg in the presence of poisoning attacks. We also validate the effectiveness of \alg using developed digital twins that model realistic highway environments to evaluate the control of autonomous vehicles under adversarial conditions.

Customer behavior modeling underpins recommendation, marketing, and decision support, yet existing approaches either optimize predictive accuracy without explaining decisions or simulate users without grounding them in real behavioral data. We present the Large Behavioral Model (LBM) that learns customer decision making directly from large-scale retail transactions through a unified Person-Environment formulation. Customer state is represented by a behavioral profile derived from historical purchases, while product context is incorporated through retrieval-augmented generation. The model is trained using continued pre-training on verbalized behavioral data, supervised fine-tuning for decision generation, and reinforcement learning with verifiable rewards for evidence-based calibration. We evaluate the proposed framework on purchase prediction, hard-negative discrimination, basket completion, promotion response, and cross-domain voucher redemption. The model consistently outperforms frontier general-purpose language models on in-domain retail tasks while demonstrating strong zero-shot and fine-tuned transfer across retailers and decision domains. Ablation studies show that continued pre-training is the primary driver of behavioral generalization, retrieval is most effective when applied during both training and inference, and reinforcement learning improves reliance on explicit behavioral evidence over generic language-model priors. These results demonstrate that behavioral knowledge encoded in transaction histories can be effectively learned by language models, providing a scalable foundation for customer digital twins and behavior simulation.

Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested. Existing reinforcement learning (RL) approaches learn fixed strategies for sepsis treatment, limiting adaptability to changing clinical objectives during inference. We propose EHRMPC, a framework that decouples learning patient dynamics from optimizing treatment by training a patient digital twin in the form of a generative electronic health record (EHR) model. The digital twin predicts clinical trajectories under interventions and enables model predictive control (MPC) to optimize treatments via inference-time planning over simulations. We evaluate EHR-MPC on a multicenter ICU sepsis cohort spanning 8 hospitals in the Mass General Brigham health system using both off-policy importance sampling and on-policy simulation-based evaluation. Relative to RL baselines, EHR-MPC achieves comparable off-policy performance and improved simulation performance. Unlike RL, this work frames sepsis treatment optimization as inference-time control over learned patient dynamics, establishing a general framework for decision making with generative clinical models.

Autonomous driving systems require reliable safety validation before real-world deployment. However, large-scale road testing is costly, difffcult to reproduce, and inefffcient for exposing rare safety-critical scenarios. Conventional simulation improves repeatability, but an offfine simulator alone cannot continuously connect physical trafffc states, virtual reconstruction, algorithm evaluation, and scenario evolution. This paper proposes a risk-ffeld enhanced closed-loop digital twin framework for autonomous driving safety validation. The framework integrates physical data acquisition, data synchronization, virtual twin reconstruction, risk-aware scenario generation, autonomous driving algorithm evaluation, and safety analysis. A driving risk ffeld is introduced as a uniffed intermediate representation to describe obstacle, lane-departure, road-boundary, time-to-collision, and comfort-related risks around the ego vehicle. The risk ffeld ranks high-risk scenarios in the digital twin scenario library and provides dense safety guidance for reinforcement learning-based driving policies. A simulation-style evaluation protocol is designed to compare conventional reinforcement learning baselines, risk-penalty baselines, and the proposed risk-ffeld guided method. The study indicates that embedding explicit risk structure into digital twins can make autonomous driving validation more targeted, interpretable, and reusable, while its practical effectiveness remains bounded by model ffdelity, risk calibration, and sim-to-real transfer.

Automated experimentation is moving from closed-loop optimization toward open decision-making, where human or AI planners must forecast the consequences of candidate actions before executing them. Such forecasts require a model of both sides of the experiment: how the sample is likely to respond and what the instrument is likely to detect. We therefore introduce a coupled digital-twin framework that separates these roles and then links them. In this framework, the sample twin encodes material state inferred from prior knowledge and measurements till the moment. The instrument twin captures signal formation, feedback dynamics, and operating constraints based on prior knowledge. When coupled, the two twins estimate expected outcomes, uncertainty, and risk for candidate microscope operations. For amplitude-modulation scanning probe microscopy, we realize this framework with a physics-informed encoder of force-distance curves, a deterministic scanner model of cantilever and feedback dynamics, and sparse learned residual corrections. The encoder first recovers scanner-driving descriptors with sub-nanometer accuracy. The calibrated scanner then reproduces typical traces within a few nanometers and identifies operating-point noise amplification as the main source of mismatch. Supplementary phase analysis localizes residual error to the phase channel, which clarifies where added physics is needed. Together, these results establish coupled sample and instrument twins as a practical foundation for predictive microscope operation and autonomous experimental planning.

Audio-conditioned generators now produce synthetic sound effects from real recordings, so the real and synthetic versions of an event increasingly coexist in sound libraries and in the corpora used to train audio models -- yet no benchmark measures whether a representation can match a synthetic clip to the specific real recording it was generated from. I introduce Doppelganger, a benchmark for matching sound effects across the synthetic-real boundary, pairing 10,420 real clips across 34 everyday sound events each with an audio-conditioned synthetic twin, alongside a controlled 7-class corpus. Off-the-shelf audio encoders do not cross the boundary cleanly. Making the embedding ignore the boundary the standard way -- training it on sound-event labels -- works on familiar sounds but backfires on new ones, dropping below the untrained encoder. Training on the pairs instead -- a clip and its own synthetic twin -- generalizes. On sound events held out of training, it recovers the exact real source about 80% of the time (up from 61% untrained; chance 0.03%), whereas no objective meaningfully improves category-level recognition on those unseen events. The learned matching is specific to one generator -- it survives changes to that generator's settings but not a switch to a different generator, and collapses for the text-only generators tested. A human annotation baseline (49 listeners) lands well above chance but below the models on the same trials. Synthetic twins fool people into calling them real about 29% of the time, yet a generator-specific detector separates these audio-conditioned twins from real recordings perfectly.

Patient-specific anatomical models provide individualized context for surgical planning, image-guided intervention, and algorithm development. However, most CT-derived models are static: they preserve the body configuration captured at scan time, but cannot represent how the same anatomy would appear after patient repositioning. This limitation is especially important for radiographic imaging, where appearance depends jointly on imaging geometry and patient pose. We present a proof-of-concept for constructing a patient-specific articulated digital twin from a single full-body CT scan. The method fits a parametric human body model (SMPL) to obtain a patient-aligned kinematic scaffold, binds segmented bones and organs to an anatomy-aware rig, and retargets body-pose changes while preserving skeletal geometry. On three full-body CT subjects, the fitted scaffold achieved 15.8 $\pm$ 4.0 mm chamfer distance and 95.9 $\pm$ 1.8% skeletal enclosure. Recomposition at the acquisition pose preserved major radiographic structure, with overall SSIM of 0.872 $\pm$ 0.016 and PSNR of 18.5 $\pm$ 1.4 dB across paired DRRs. Across unseen target poses, the resulting twins enabled articulation while maintaining high skeletal enclosure (94.4 $\pm$ 0.4%). As a feasibility demonstration, we render the articulated twin as pose-dependent DRRs. These results suggest the feasibility of extending static, view-controllable CT simulation toward pose-controllable anatomical twins for future synthetic imaging and positioning studies.

In the verification of in-vehicle cameras, simulation technology using virtual spaces has advanced, enabling pre-evaluation of false detections and missed detections in various scenarios. However, discrepancies in the scale of the object being verified between the virtual and real environments can lead to a decrease in camera recognition performance. For traffic signs installed at high altitudes, distance measurement using LiDAR or stereo cameras is difficult, requiring size estimation from monocular images. This paper proposes a method for estimating the scale of an object by decomposing it into multiple structural elements and integrating external knowledge regarding design rules, geometric relationships, and conventional dimensions. Specifically, this method detects each component from a monocular image and estimates the size of each component by considering its structural relationships and dimensional consistency with surrounding elements. Furthermore, it generates a 3D asset of the object by reconstructing the estimated components. This method makes it possible to place 3D assets with a scale approximating the real environment within a digital twin space and is expected to contribute to improving the verification accuracy of in-vehicle cameras for autonomous driving in virtual environments.

We propose an agentic Large Language Model (LLM) framework for active Fault-Tolerant Control (FTC) that transforms fault detection outputs into constraint-aware recovery actions grounded in plant-specific knowledge. The approach couples (i) a multi-agent workflow that decomposes operator duties into monitoring, planning, action synthesis, simulation, validation, and reprompting; (ii) a Digital Process Plant Twin (DPPT) that exposes plant data, models, and a simulation service for pre-execution testing; and (iii) a Graph Retrieval-Augmented Generation (Graph RAG) layer built on the CPSMod ontology, which organizes plant knowledge (structure, function, hybrid dynamics, control context, and fault semantics) into a graph that supports relation-aware, multi-hop retrieval for the agents. Corrective actions are generated as minimal-risk state-machine recovery paths and corresponding discrete commands or continuous setpoint adaptations, then validated deterministically against interlocks, envelopes, and dynamic feasibility before any actuation. If no acceptable plan is found within a bounded time window, control is handed to a safety fallback. The framework is evaluated in simulation on two representative benchmarks: a discrete batch Mixing Module and a Continuous Stirred-Tank Reactor (CSTR) under closed-loop PID regulation. Results with lightweight LLMs (GPT-4o-mini and GPT-4.1-mini) show that semantically grounded agents can derive valid recovery decisions within latency budgets compatible with the respective process dynamics, demonstrating a practical pathway from detection to validated corrective action across both discrete and continuous FTC tasks.

Digital twins have emerged as a promising paradigm for personalized healthcare, enabling modeling of individual behavior and health trajectories. In cognitive health, early detection of Mild Cognitive Impairment (MCI) remains challenging, where language and conversational patterns serve as non-invasive biomarkers. In this work, we propose a language-based digital twin framework that leverages large language models (LLMs) to mimic the conversational behavior of elderly individuals by incorporating stylometric cues and contextual metadata. To evaluate fidelity and cognitive consistency, we introduce a multi-head conditional variational autoencoder (cVAE) that jointly measures reconstruction quality and predicts cognitive scores. Experiments on the I-CONECT dataset show that the digital twin preserves identity-specific characteristics and achieves reconstruction and MoCA prediction errors comparable to real data, while outperforming baseline GPT-generated responses. These results highlight the potential of language-based digital twins as a scalable and non-invasive approach for personalized and continuous cognitive health monitoring.

A digital twin (DT) is a virtual model of a real-world system that can assist decision-making by simulating scenarios induced by different policies. However, typical machine learning-based DTs do not optimise for this use case. We prove that, when model capacity is limited, training DTs to minimise one-step transition errors can produce suboptimal models for ranking sets of policies according to a reward function. We further show that this holds empirically, even with expressive model classes. To address this, we introduce $\text{DT}^2$, a decision-targeted DT training paradigm. Firstly, $\text{DT}^2$ uses fitted Q-evaluation to estimate values of candidate policies from offline data. A DT is then trained to generate rollouts that preserve pairwise policy rankings derived from these proxy ground-truth values with an architecture-agnostic loss function. We empirically demonstrate the efficacy of our method across a range of settings and architectures. $\text{DT}^2$ consistently improves policy ranking and reduces decision regret during policy selection relative to conventional DT training, both for policies used during training and for unseen policies, while maintaining a good level of raw simulation fidelity.

Accurately predicting the spatiotemporal evolution of amyloid-$β$ and tau proteins at the individual level is critical for improving the diagnosis and treatment of Alzheimer's disease. We consider the problem of constructing patient-specific digital twins that model the propagation of these biomarkers on the cortical surface using reaction--diffusion dynamics. A major challenge is that the underlying nonlinear aggregation mechanisms are unknown and must be inferred from sparse, noisy, and heterogeneous longitudinal PET imaging data. To address this, we develop a data-driven framework that learns biomarker dynamics directly from clinical observations. The approach combines operator learning with reduced-order representations to infer governing equations of disease progression from data. Using this framework, we achieve predictive accuracies of 87% for amyloid-$β$ and 81% for tau. Building on the learned dynamics, we further formulate a PDE-constrained optimal control problem to design personalized therapeutic strategies that regulate pathological protein propagation. By integrating data-driven dynamical modeling with treatment optimization, the proposed digital twin framework provides an interpretable and predictive platform for understanding disease progression and enabling precision interventions in neurodegenerative disorders.

Deploying robots in unstructured real-world environments needs accurate, interactive models of the objects. Constructing these models at scale remains a critical bottleneck for robotic system integration. We present ArtiTwinSplat, a framework that automatically constructs articulated, photo-realistic digital twins of objects directly from RGB-D videos, requiring no CAD models, simulation assets, or manual annotations. Our method is built on 3D Gaussian Splatting that preserve geometric fidelity and photometric realism, coupled with an unsupervised articulation discovery pipeline that recovers part structure and joint kinematics from observed motion alone. With tracking and optimization stages our method provides stable, queryable digital twins that support real-time rendering, viewpoint control, and interactive manipulation. Unlike prior methods confined to simulation, ArtiTwinSplat operates directly on real-world observations and produces twins that are immediately usable by downstream robot planning and learning systems. This method offers a practical, scalable pathway toward digital twin construction, lowering the integration barrier for articulated object manipulation in embodied AI and human-robot collaboration contexts.

Bathroom use is a critical safety challenge for older adults because wet surfaces, constrained layouts, limited support, and frequent posture transitions are concentrated within a small domestic space. These conditions create risks that cannot be adequately understood by considering either the bathroom environment or human motion in isolation. Existing bathroom safety studies mainly identify hazards, accessibility problems, or design modifications, whereas human-centered sensing studies often focus on activity recognition or fall detection without sufficient semantic understanding of the surrounding environment. This separation limits the interpretation of how older adults interact with fixtures, support surfaces, wet areas, and spatial constraints during daily bathroom activities. To address this gap, this study proposes a bathroom-centered human-building digital twin framework for interaction-aware indoor safety analysis with a specific emphasis on older adult bathroom safety. The framework conceptualizes bathroom risk as a coupled human-environment process and integrates semantic bathroom representation, skeleton-based human representation, spatial-semantic coupling, interaction-aware event analytics, and safety-oriented visualization. A Unity-based proof-of-concept prototype is developed to demonstrate the feasibility of the framework. Although the current work remains a prototype-oriented investigation, it establishes a methodological basis for analyzing older adults' bathroom safety through explicit body-environment relations and for advancing privacy-sensitive, interaction-aware digital twin applications in aging-in-place residential environments.

Digital twins (DTs) have become a potential technology to perform risk-free simulation of physical entities for deterministic and high-reliability services in diverse scenarios such as autonomous driving and low-altitude economy. In the autonomous driving scenario, traditional DT methods that rely solely on vehicle's real-time state synchronization, however, might lead to unacceptable computing and communication consumption for construction of high-fidelity DT with redundant data. To address this issue, we first propose a query-driven DT architecture to enable the DT to actively request the desired environment data from vehicles based on its simulation result. Then, we formulate an optimization problem whose goal is to minimize autonomous driving position error while accounting for DT fidelity and communication constraints. We also design a cross-time-step progressive query mechanism to further improve communication efficiency. The simulation results show that our proposed method achieves a 24% reduction in planning position error compared to traditional methods, while reducing communication overhead by 40%.

Precision medicine in ophthalmology requires accurate longitudinal predictions, but the fragmented nature of multimodal clinical data remains a barrier to forecasting. We introduce OphthaDT, an LLM-based digital twin for ophthalmology that serializes longitudinal patient histories from 3,220 patients across four Phase III clinical trials into structured narratives to forecast best corrected visual acuity (BCVA). In benchmarks spanning up to 100 weeks, OphthaDT demonstrated the lowest prediction error in neovascular age-related macular degeneration (nAMD), achieving an average mean absolute error (MAE) reduction of 6.0% compared to all baselines. In diabetic macular edema (DME), OphthaDT demonstrated competitive performance against all baselines while outperforming Random Forest and XGBoost by an average MAE reduction of 2.6% and 6.9%, respectively. Results reveal that OphthaDT's predictive advantage scales with trajectory complexity: whereas linear models remain effective for the more stable treatment responses of DME, OphthaDT's capacity is better suited for capturing the high longitudinal variability of nAMD. Finally, OphthaDT handles irregular sampling without imputation, positioning LLM-based clinical trajectory modeling as a methodology that could reduce patient burden and accelerate drug development.